{module Science Square (Issue 128)}

First miniature human heart printed

Noor N et al. 3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts.  Advanced Science, April 2019.

In a major breakthrough, researchers have “printed” the world’s first 3D vascularized engineered heart using a patient’s own cells and biological materials. This could have huge repercussions for human health: the World Health Organization said that last year, ischemic heart disease and stroke were the world’s leading cause of death for both men and women. Heart transplantation is currently the only treatment available to patients with end-stage heart failure. Given the serious shortage of heart donors, scientists have been trying to develop new “3D organ printing” approaches to regenerate the diseased heart. Past studies were only able to print simple tissues without blood vessels. The new study showed for the first time that an entire heart with cells, blood vessels, ventricles, and chambers could be successfully engineered and printed. The researchers first took a biopsy of fatty tissue from patients and separated the cellular and a-cellular materials of the tissue. While the cells were reprogrammed to become pluripotent stem cells, the extracellular matrix – a 3D network of extracellular macromolecules such as collagen and glycoproteins – were processed into a personalized hydrogel that served as the printing “ink.” After being mixed with the hydrogel, the cells were then robustly differentiated to cardiac or endothelial cells to create patient-specific, immune-compatible cardiac patches with blood vessels and, subsequently, an entire heart. The heart was 3D-printed in about three hours and was too small for humans. It was the size of a rabbit’s heart (~ 2.5 centimeters). But it is completely biocompatible and, most importantly, matches the patient, which reduces the chances of organ rejection inside the body. A human-sized heart might take a whole day to print and would require billions of cells, compared to the millions used to print these mini-hearts. While it’s not clear if a printer can produce hearts that are equal or superior to human ones, perhaps by printing patches there will be a possibility to improve or take out diseased areas in the heart and replace them with something that works. Researchers hope that maybe in 10 years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely.

Bacterial factories for spider silk

Zhang F et al. Synthetic Biology for Microbial Production of Protein-based Materials, the American Chemical Society (ACS) National Meeting & Exposition, Spring 2019.

Spider silk has always fascinated researchers due to its lightweight and superior strength and numerous applications in areas such as drug delivery, smart textiles, and artificial muscles. It is one of the strongest natural materials in the world. It is thinner than a human hair, but its strength is more than that of steel, pound for pound. Since farming spiders is incredibly inefficient, scientists have been trying for decades to find a way to mass produce the material from genetically modified bacteria, yeast, and even goat milk, but these efforts have always fallen short. The biggest challenge was that the genetic information for dragline silk is a long string of repeating DNA, and, in previously tested organisms, cellular machinery arbitrarily alters or chops up such DNA sequences. To circumvent this problem, researchers precisely separated the repeating DNA into bits and inserted each repeating piece separately into bacterial genome. These smaller DNA pieces produced small peptides that ended up combining in bacteria and formed a strand of silk. The researchers also added to the end of each strand a chemical tag that glued the individual fibers together. This method was able to produce 2 grams of spider silk for each liter of bacteria and the resulting material behaved exactly like dragline silk. Its tensile strength was measured at 1.03 gigapascals, about the same as for naturally produced dragline silk. The engineered silk’s toughness measured 114 megajoules per cubic meter, compared with around 100 megajoules for silk made by spiders. And the engineered silk strands could stretch 18 percent before breaking, the same as natural dragline silk. The new silk was developed in part with NASA funding for applications such as giving astronauts a means of producing tough materials while on Mars. But the substance could be used in designing stronger materials for robotic, medical, or textile applications.

Electricity from falling snow

Ahmet A et al. All printable snow-based triboelectric nanogenerator. Nano Energy, April 2019.

Researchers have designed a new device with which we can now obtain electricity from falling snow. This new energy conversion method could become a new source of electricity in the future, especially in remote areas, as it does not need batteries. Researchers called it a Snow-based TriboElectric NanoGenerator, or Snow TENG. It is inexpensive, small, thin, and flexible like a sheet of plastic. After starting a charge from static electricity, energy is generated from the exchange of electrons. Snow is already positively charged by giving up its electrons, while silicone, a rubber-like material which consists of silicon atoms and oxygen atoms, is combined with carbon, hydrogen, and other elements to be negatively charged. When the positive-charged snow falls onto the surface of the silicone, the charges interact, and the Snow TENG captures the charge, which allows it to turn snowfall into electricity. 30% of Earth’s surface is covered by snow each winter, which is also the time when solar panels, one of the most reliable renewable sources of energy, aren’t very effective. Snow accumulation reduces the amount of sunlight that reaches the solar array, which makes them unable to operate. Snow TENG could be integrated into solar panels and provide a continuous power supply, even at a time when it’s snowing. Researchers used 3D printing to design the small device. It consists of a layer of silicone and an electrode which can capture the electric charge. Given that silicone is widely used in the industry, this method could dramatically reduce the global costs of producing electricity.

Question: Among the characteristics of “ignorance” that his followers would not completely abandon, the Prophet Muhammad, peace be upon him, mentions boasting on the basis of one’s rank, reviling others’ genealogies, expecting rain from the stars, and wailing extremely over a lost loved one [1]. What are the lessons to be drawn from this saying?

Answer: 

Boasting of one’s merits is a deception

Boasting about any quality like status, nobility, knowledge, wealth, beauty or intelligence, etc. signifies disrespect toward God. For Bediuzzaman, disregarding Divine favors is ingratitude, whereas laying claim to them is boastfulness. So, if a person wishes to avoid both ingratitude and boastfulness, he must acknowledge that all these blessings such as knowledge, wisdom, reason, judgment, wealth, health, and the like, come from God. If necessary, a person should only mention them in the form of acknowledging God’s blessings.

Boasting and vanity are qualities disliked by God. Even if a person is descended from the pure lineage of the noble Prophet, he must say: “My God, coming from such a blessed lineage is not something in my control. I know that You are the One Who blessed me with it. This goodness belongs to You and it is a heavy responsibility for me at the same time. My Lord, I praise You with thanks for having bestowed on me this favor and I ask for Your help so that I can give this responsibility its due.” No one should ever use this as a way to assume superiority over others.

Being a descendant of a general, coming from a wealthy family, being the child of a high-ranking bureaucrat … none of these bear any value in the sight of God. In this respect, no matter at what level, a person should not commit a mean act by being boastful of one’s family and should not see this as a factor of superiority. The merits of one’s ancestors are of no benefit whatsoever for a person. What really matters is having worthy personal values: “Surely the noblest, most honorable of you in God’s sight is the one best in piety, righteousness and reverence for God” (Qur’an 49:13). The measure of an individual’s value is related to that person’s worship, the quality of his or her relationship with God, and whether that person leads a God-conscious life; acting with the knowledge that God sees everything and as if one were able to see God. If a man does not stand where he should, descending from a noble lineage will be of no benefit to him at all.

Superiority by lineage

Secondly, the Messenger of God referred to the issue of holding others in contempt on account of their ancestry. While a person’s coming from a humble background and being the child of a shepherd does not reduce that person’s value at all—as stated above—coming from such and such lineage does not bring any virtue either. The following couplets of Ibrahim Haqqi summarizes this situation well:

“Haqqi come, do not reveal your secret;
If you wish to progress on this path,
Do not deride the wretch my dear;
There are such wretches that hide a treasure.”

It is definitely wrong to reproach and deride people by looking at their cultural environment, material status, neighborhood, family and the like. Ideas of superiority, and seeing others as inferior, date back to a more distant past. In the present day, this understanding continues in overt or covert forms in many places in the world. There is a caste system in different forms and manifestations around the world despite so many claims of progress in civilization, democratization and human rights.

Fortune telling by the stars

Another characteristic of the Age of Ignorance that continues to survive is the issue of expecting rain from the stars and ascribing the coming rains to the stars. In Mesopotamia particularly, the people deemed the stars to imbue a special holiness. The people of that land believed the stars to be directly influential on a person’s destiny. Although such beliefs do not exist in our time, belief in fortune telling by the stars and horoscopes still continues showing that this tradition of the Age of Ignorance remains in different forms.

In relation to this subject, the noble Prophet, peace and blessings be upon him, expressed that God Almighty stated:

“On this morning, some of My worshippers remained as true believers and some became unbelievers; he who said that it rained with the blessing and mercy of God is one who believes in Me and does not believe in the stars, but he who said it rained because of such and such (star) does not believe in Me and believes in the stars.”

Then, seeing the falling rain as a manifestation of God’s mercy and responding to it with praise is a sign of faith, whereas ascribing it to simple causes, such as the stars, is a sign of associating partners with God. If God Almighty had rendered the stars a veil before the operation of His power and greatness, it could have been acceptable to see them as causes. However, as the natural sciences have also proven, there is not even a direct relation of causality between the stars and rainfall.

Unfortunately, when people do not believe in what they should, namely, when they do not have sound faith in God, the Prophets and the Qur’an, the natural need for belief in something, that is an attribute of human nature, leads them to believe in falsehoods. While some seek help in yogism or meditation, others try to find satisfaction with horoscopes and the like. All of these block the ability and potential of the human soul from accepting the real truth. Human nature is inclined to a quest for the truth but sometimes people put on the hat of falsehood and try to satisfy their heart, which actually yearns for the truth, with stones, trees and stars instead, even though those are not even conscious beings.

Culture of wailing

The final point stated in the hadith is wailing over the dead. In some parts of the world, there still exist certain forms of mourning where people slap their hands on their knees and cry artificially like performers.

However, this exaggerated display of emotions is of no benefit to the deceased whatsoever. If a person did not attain closeness to God through worship, and did not live as an obedient servant while in this world, it is of not much of a benefit for him (or her) even if a large crowd attends his funeral, sings his praises, or bears witness that he was a good person. In addition, it also needs to be stated that knowingly giving a positive account of an evildoer is bearing false witness. We surely make judgments according to the outward reality. Only God knows what is in one’s heart. If a person has passed away with faith and righteous deeds, the number of people who attended his or her funeral does not really matter. Millions of people attended the funerals of so many pharaohs and other tyrants, but this does not absolve them from the sins of their atrocities and oppression.

As a matter of fact, the noble Prophet said that if forty people bear positive witness for a deceased person, that person will be forgiven. However, as I have tried to point out above, this does not apply to knowingly bearing false witness. The Messenger of God made the following address to Abu Hurayra as a warning against death:

“Restore your ship, for the sea is deep. Take your provisions perfectly, for the journey is truly long. Keep your load light, for the slope before you is truly steep. Preserve sincerity in your deeds because God, The All-Seeing and Righteous One, is well aware of any of your acts” [2].

These were the points the Messenger of God found worthy of emphasis. If you pass away having remained within such a righteous sphere, then you will have passed to the pure horizons of our soul and be blessed with the truth of: “Surely we belong to God (as His creatures and servants), and surely to Him we are bound to return” (al-Baqarah 2:156). Otherwise, the wailings and praises—even if performed by millions of people—and the crowds attending your funeral will do you no good at all.

Notes

[1] Hakim, Al-Mustadrak, 1/539.

[2] Daylami, Al-Musnad, 5/339.

Life is over, only its silent voice remains,
Entrusted to the next, its breath remains;
I know not what I will be in the beyond,
Only a broken plectrum’s melody remains.

From the memories of the days now past,
From the silent whom I thought were friends,
From the words repeated at every breath,
Only its rank-struck, dry lyric remains.

Yesterdays yellowed as if fall has hit;
Sorrow rests now on faces once lit;
Past now scattered with a blown wind,
What is done is done, its lament remains.

Birds we were, chirping, “It will appear”
Flew we did, seeking a lofty ideal;
And now it is time to fly beyond there,
From this worldly lie, only a tune remains.

Translated from Turkish by Lina Cakmak

Respect for life is more than a religious value; it is a constituent dimension of faith found in every major religion of the world. One cannot have faith in a creator God (or an all-embracing transcendent reality) and cavalierly exclude any part of creation—the whole natural and cosmic world are worthy of respect. To affirm the inviolability of the person is to affirm the sacredness, the mystery of the cosmos. Creation is inseparable from the dignity of the cause of its being. While the story of Creation in the Hebrew Scripture has been interpreted in many Christian circles as permission for humans to exploit creation, Genesis’ first chapter express a relationship of respect and responsibility for all that God has brought about. And Muslims affirm: “Indeed, God is the cleaver of grain and date seeds. He brings the living out of the dead and brings the dead out of the living” (Qur’an 6:95).

Respect for life, especially among certain radical Christian groups, is viewed by a broader public as an almost exclusive preoccupation with abortion and medically assisted death. The Christian maxim, “love your enemies and pray for those who persecute you” (Matthew 5: 44), is often ignored by both the advocates of capital punishment in North America and the perfunctory trials and death sentences currently being meted out in Iraq. It is not difficult to understand how the obscene presence of evil in the world alienates religious people from the demands of “true goodness, true responsibility, true justice, a true sense of things—all [of which] grow from roots that go much deeper than the world of our transitory earthly schemes. This is the message that speaks to the very heart of human religiosity” (Vaclav Havel).

Human religiosity must have its concrete embodiment in the everyday lives of people. Religious truths ring hollow and defy belief, when they remain concepts outside the day to day hopes and fears, joys and anxieties of experience. The true believer is not one who assents to a series of propositions, no more than one can be labelled an infidel, because a religious teaching seems irrational. In fact, the divine—Yahweh, Allah, or the Father—is imminently beyond comprehension and the communication of the divine reality is always conditioned by the lives of those who embrace one or the other religious traditions.

The United States, Israel, Islamic nations, and lately even Russia are laying claim to their religious roots. But their vision of religion and faith seems more polytheist and politicized. They all acknowledge “one” God, yet fail to recognize that God in the putative enemies. What does a message of peace—Shalom, Islam, and the beatitudes—sound like when so much violence and disrespect for life are evident in daily confrontations? Rationalizations relying on national interest or national security appeal to general bias and reduce rich religious realities to icons of more primitive human insecurity and mistrust. The will to violence, in fact, reveals the religious bankruptcy of many of these powers.

As a practicing Christian I am conscious of the disconnect between the clarity of the Gospel teachings and the political and cultural agendas of many of my co-believers who often take their religious “truths” out of context, then use these truths as ideologies, without exploring the impact of their choices on the core message of Jesus. Often what it means to be Christian is reduced to the vehement insistence on single issues as the touchstones of orthodoxy. Abortion, the fate of the city of Jerusalem, or support for our troops (whoever we are, whatever their mission) have become in many quarters stand-alone issues, without regard for the context and consequences. Legitimate concern for the safety of their family members too often confuses faith with patriotism and blinds Christians to the destruction war brings to the lives of the “enemy” and the millions of civilians whose lives are daily being taken by death or by hopelessness.

Westerners can “reclaim” their Christian heritage and Jews demonstrate moral integrity by figuring out what Yahweh meant when he reminded them: “You shall not molest or oppress an alien, for you were once aliens yourselves in the land of Egypt” (Exodus 22:20). Muslims, Jews, and Christians can share a stronger hope for achieving peace and affirming human dignity, through reviewing their own religious commitments from the perspective of God the Creator, of Allah, the beneficent and merciful.

As a Catholic I find hope in the attitude and actions of Pope Francis. In a most public fashion the Pope has welcomed asylum seekers and reminded Europe of its obligation to receive them. He has promoted an environmental morality that ties the fate of human life and wellness with the fate of our natural environment. He continually stresses that there is no such thing as less worthy and more worthy human beings. But this willingness to hear the cry of desperation in the voices of asylum seekers and to seek social and ecological justice is not limited to religious groups—an indication of the universality of humankind that religious particularism too easily ignores.

At the same time, there are growing movements in Europe that refuse to welcome these quasi-stateless persons, who have lost their homeland. Often they express fear that the predominantly Muslim refugees threaten Europe’s Christian culture, without realizing that integral to that culture are the works of mercy, the care for the marginalized, the victims of decisions of the powerful and mighty of this world. Nations and businesses continue to disrupt the ecology. They are unable to resist the allure of the wealth, which they believe regulation will prevent them from achieving. Morality and faith are two sides of the same coin. Faith brings one into the dynamic movement of divine compassion and creativity. Morality is allowing God’s being to become compassion and creativity in our own lives. We do not hold God to a “higher standard,” as if there are situations in which humans have the right to unleash the violence and blood-shed of war, to irreparably violate the environment, or to destroy the soul of another. “Do not forget your share of the world. And do good as God has done for you. And desire not corruption in the land” (Qur’an 28:77). The Golden Rule may seem on the surface to be a formula for self-protection (if you don’t want to get hurt, avoid hurting others). Yet, in fact, it captures the interconnectivity of all creation. The gift of life underscores responsibility for life, for all life is interconnected. “…whoever saves the life of one, it shall be as if he had saved the life of all mankind” (Qur’an 5:32).

Religion in public life can, at its worst, lead to oppressive theocracy, social hypocrisy, and disregard for the dignity of persons and groups of people. It easily obscures the loving compassion of the God, whose will it claims to honor. Yet, religion—humbly lived and with a consciousness of its own failures—has a right and a duty to speak openly about the values that make human life together a pursuit of the common good, rather than the survival of the fittest. But if religion is to play a constructive role in the public sphere, it will be necessary to find areas where the adherents of different religions share common goals, values, and beliefs. Polarization within and between religions readily cedes its rightful place in the public sphere to divisive ideology and needlessly blocks working together for the common good. In fact, it becomes false religion by fostering a self-referential morality that narrows the universalism of the original creation and selectively ignore some of the most challenging, yet ennobling, teaching of the most sacred scriptures available to humankind. Religion is not about a vague “more than life,” as if life were something less than what humanity and nature really yearn for. Religion is about life itself and the duty of every believer is to protect and nurture life. That is true worship, for all life is the presence of God in our midst.

When you ride a rollercoaster for the first time you feel a surge of emotions that grab, terrify, and haunt you all at once – well, at least at the start. But once you get over that first drop, that first mind bending, gut wrenching drop, you suddenly realize that your life isn’t over. And not only is your life not over, it’s also exciting anticipating what else is around the corner.  When the adrenaline takes over, the fear of the impending disaster dissipates.

That’s what pregnancy was for me. I had the initial fear seeing the digital test flash “pregnant.” That fear wasn’t because it wasn’t planned – technically, we did plan. We got married, bought the nice house in a subdivision, and had a fantastic waiting period of five years so that we could explore married life without kids. The fear was the feeling of “oh no, what have we done?!”

And I wasn’t the only one who felt it! My husband had that look on his face when I showed him the test. He didn’t jump around with joy or even smile; he just looked at me with an expression of confusion and worry that settled somewhere closer to acceptance. You would have thought we were two fifteen year olds still in high school with no life achievements. But what mattered most wasn’t our initial reaction. What mattered was the journey we were embarking on together as husband and wife. The excitement hit us quickly enough, along with the extreme nausea and vomiting that plagued me for months.

My husband always wanted a beautiful baby girl. That was his desire from the start. I don’t have to explain how happy he was when the ultrasound tech told us what we were having. We decided to have a nice small and intimate reveal party, just for the grandparents. We got the idea to get cute pink build-a-bears to give to the prospective grandmothers and we revealed our daughter’s name along with the due date. It was exciting and wonderful.

But life always has a drop waiting around the corner. It never fails: impending doom lurks, waiting for its next victim. It wouldn’t be a journey if it didn’t have obstacles. So that is what I first thought when my OB/GYN called me to come to the office exactly one week after the reveal party. But I could have never prepared myself for the words “positive for Down syndrome.” I kept thinking, how could this be? My husband and I were both still in our twenties and healthy, with no family history of anything more than diabetes. This couldn’t happen to us! I stared at my husband, and he had the look of suffocation, as if the room had been stripped of oxygen. We rushed home to do research, to ease our minds into believing that the prenatal test was inaccurate or wrong. We even grasped at the straw of someone in a lab mixing my blood with someone else’s. Our parents reassured us that it was a faulty test, it happened all the time in the eighties and early nineties. My husband held fast to thoughts of positivity, but I ventured into the realm of realism very early because I knew that life always gives you something that you perceive to be unfair and unbearable. That drop was unbearable.

The twist and turns came in the next few months with the fantastic ultrasound test that showed no signs of Down syndrome at all on our little one. But of course, me being the president of the realm of realistic notions, I couldn’t allow myself to be too relieved. But could anyone really blame me? I mean if my child was to be born with Down syndrome, wouldn’t I, as her mother, need to be there for her? If the doctor pulled her from my womb and the true visualization of her features set in, and she bore obvious signs of that extra chromosome, I would still reach for my child and hold her tighter than a mother bear.

My husband and parents could step out of the room and regain their composures, while going through the stages of grief all the way to acceptance and unconditional love. But me, being momma, I needed to go through that ahead of time, so when my baby girl was handed to me the only thing she would feel was my undying and unwavering love for her.

I did the only thing I could do: I prayed. Not to take away any disabilities or deformities. How could I? How could I be so presumptuous to ask God to make my life any easier than the next person’s? No one has it easy. No, instead I prayed for a healthy beautiful baby girl. And I spent hours telling God “thank you.” I was grateful that I could conceive, and that I had a great husband who also would love our daughter unconditionally. I was thankful for the roof over my head and the qualities that my loving parents instilled in me, because during my pregnancy there was barely a week that went by without hearing about a woman killing or abandoning the baby she didn’t want. I was thankful to have compassion and natural human affection. I spent hours crying and speaking my peace with God, knowing that no matter how different she might be, my daughter was a direct gift from Him and I knew that I only wanted what was best for my child, which is to be better than me. That is what all parents truly want.

When the delivery was over, so was that ride of loops and drops. Because when they handed me my little girl all I saw were her perfections, no flaws. And my husband thanked me for bringing our child into the world. Even now, two years later he still thanks me, and I still thank God because he answered my prayers.

This entire ordeal taught me many lessons about life and our ability to make it harder than it needs to be. Sometimes we ourselves are the disasters we try so hard to avoid. It’s our thinking and our mindset that end up getting the best of us and turning something that can be conquered into a mountain of pain. I learned that you don’t have to be a saint to put trust in a higher power to guide you. I could have allowed the fear of the unknown to destroy me, to cause me to become so paralyzed that I lost my ability to avert a disaster. We all have that ability, regardless of what life sends our way. Beauty is in the eye of the beholder, but also what we perceive as a catastrophe is ultimately left up to our own interpretations.  

Now I am on a new rollercoaster ride. New twists, turns, and drops, each one filled with thoughts of fear and despair. But this ride is called motherhood. Every day I am forced to reset my thinking and my viewpoint on things. I remind myself that it is my choice as to whether something is a mountain or a molehill. Do I choose to wallow in negative thoughts of impending doom or do I look for the way out of the tunnel, the light that is always at the end? Because when I look at my life over the past couple of years, every disaster that has come my way has made my family and me stronger and more versatile. And every blessing that has come our way is received with gratitude and graciousness.

Do I see everything through rose colored glasses now? Not in the least. I was and will always be a realist. Seeing life for what it is will constantly require an endless readjusting of our minds. The truth is, we never truly stop riding the rollercoaster. We can only hope to learn how to enjoy it as much as possible. If we don’t, we are doomed to see every event as something to cower in front of. You don’t get to know when it is coming, and you don’t get to know what it will be, but you do get to choose how it will affect your life: mountain or molehill? I choose to see the twists and turns of my pregnancy as the blessing they always have been. My daughter has no real health issues or problems, no heart defects and no developmental delays. She is healthy and beautiful, with a smile that will bring the world to its knees. All that I truly wanted was for my baby girl to be healthy and smart. She is beyond everything I could have dreamed possible. When I look into her eyes, I am aware that she may have difficult days ahead, but she will have many happy ones, and on her worst day she is still better than I am.

Amyotrophic Lateral Sclerosis (ALS) is a terminal illness of the nervous system, resulting in the degeneration of neurons. When the motor neurons in the lateral spinal cord degenerate, the muscle cannot be stimulated and gradually atrophies. As the disease progresses, the brain cannot initiate and control muscle movement, so voluntary muscle actions, such as reaching for your phone or typing on a keyboard, are lost. Currently there are no treatments or cures to reverse the effects of ALS and the disease process is still widely unknown. Some noteworthy individuals diagnosed with this disease have included Lou Gehrig, Stephen Hawking, Jon Stone, George Yardley, Henry A. Wallace, and Steve Gleason. These are the facts, but I could have never realized what living with ALS was like until I listened to a retired senior, a teacher, and a musician tell me their stories.

The older couple told us of their past year as the husband wrote on an electronic note pad to fill in the gaps of his spouse’s version of their story. They had first noticed his symptoms when he began choking on his food, and they had to adapt as the disease progression got more and more severe. His wife comically said that she doesn’t know where to look when he’s trying to talk to her – “Should I look at his eyes, his mouth, this pad?” Every day, they had to face a new challenge and overcome it together, as a family.

Another patient was a mother, a teacher, now wheelchair bound and with a respirator to help her breathe. Because of her age, none of her physicians expected ALS and thought she was struggling from carpal tunnel syndrome or an ulnar nerve injury. She told us her husband was her biggest caregiver and supporter; her husband joked, “She makes the list and I carry it out.” He talked about his struggles, working full time as well as being a full-time caregiver for his wife and their 3-year-old daughter, as well as still finding time for self-care. Even with all this juggling, he felt guilty. This guilt was expressed by many of the caregivers: some because they didn’t even notice the symptoms and others because they felt like they couldn’t help their spouses. Guilt was felt by the patients too. The mother was upset because her daughter would only remember her in a wheelchair. Despite the difficulties, family was a major support system for each patient.

When asked about how she felt after getting her diagnosis, the musician said, “I felt like a deer in headlights… I never pictured I was going to go out that way… with a terminal illness… Last year I had no trouble walking, singing, cooking, gardening, and this year…” Despite all of this, she said she felt relieved. Her struggle to find a neurologist who respected her was heartbreaking. She had gone to a physician because she felt helpless; she was having trouble playing guitar, she was losing her identity as a musician. However, the physician assumed from her past medical history of anxiety that she was having mental issues with memory, anxiety, and depression. As she continued to receive hostile treatment, she found a second doctor who listened to her. Unfortunately, even though he took her seriously, he didn’t have the courage to diagnose her with ALS, telling her instead that she had a motor neuron disease and referring her to a specialist. When she finally received the diagnosis of ALS, she was relieved. She no longer felt crazy. She was able to be heard. She was able to communicate with someone who wanted to help her. ALS is already a hard disease to diagnose; not having someone on her side only made her situation more difficult. She says now, as each symptom appears, she isn’t afraid anymore, because she knows it’s ALS. This relief of having a concrete diagnosis, of having a diagnosable disease, even one that is untreatable, was reiterated by several of the other panelists.

Although a diagnosis was a relief for many of the patients, they all saw the importance of taking part in clinical trials. They recognized that ALS affects everyone at different times in different ways and hoped that one day they could explain why this illness is so hard to detect and track. Participating in various studies and trials made them feel like they were helping future patients and physicians to be able to better understand why this terminal disease can strike at any time, with no discernable warning signs, affecting each individual uniquely in initial symptoms and progression.

Getting a concrete diagnosis gave these patients the freedom to seize the day and live in the moment. For the musician, as her ability to play guitar diminished chord by chord, and she started slurring her words, preserving her voice and her identity became very important to her. She is using a message banking app to preserve her voice. The software requires her to read thousands of words and sentences. Although she had to accept the things she could no longer do, she realized that she did not have to give up her identity or love of music because of ALS. Overflowing with her love of music, she told us about how when choirs sings together, their hearts become synchronized; and how music lowers blood pressure and stimulates all areas of the brain. As she interwove details about her symptoms with her favorite song, Fire on the Mountain by the Grateful Dead, the two had become part of the same spiritual transformation. Smiling peacefully, she explained, “Maybe nobody else hears it the way I do. I see death as the final healing, finally being released from your body.” She viewed her diagnosis as graduating early and the symptoms that came attached with it as her disappearing slowly, rather than all at once. The unavoidable indignities were just something she had to accept. What mattered most to her was keeping her individual personality in the face of intense daily struggles.

By the end of our discussion, I felt the weight of my white coat as I never had before and recognized that this would be the first of many times that I would have to carry this symbol of patient advocacy. As these patients spilled all their vulnerabilities to a group of 50 students, I realized the most important thing I will learn in medical school is opening my heart without getting crushed under negativity. I learned that, as doctors, we have the tendency to think the ultimate solution is life, when in truth, mortality is the reality. What matters is being present when there is a fire, realizing that “a pail of water” may not be enough to put it out, but continuing to carry that water for your patient.

Long distance runner, what you standin there for?
Get up, get out, get out of the door

There’s a dragon with matches that’s loose on the town
Takes a whole pail of water just to cool him down
-The Grateful Dead

We eat, sleep, and go to the bathroom. Yet, we never think about how all these physical needs are processed in the systems of our body when they are functioning normally.

Yes, our bodies are created with perfect systems by which our all kinds of needs are met. The digestive system is one of them. Our intestines are key elements of this system, so much so that asking someone “How are your intestines?” would be as comprehensive as asking “How are you?”

Digestive system

Food is critical to life. A human being can bear hunger for one month at most and can only endure a few days of drought. Thus, eating and drinking is crucial.

Foods as we eat them are not convenient for use by the cells. Food must be broken down into smaller pieces. This process begins in the mouth and ends at the anus, and it is called digestion.

The main task of our stomach and intestines is digestion. The teeth, salivary glands, the tongue, and the gullet – as well as swallowing – are essential secondary elements. Additionally, if the pancreas or liver fall ill, it can paralyze the whole system. While also working with the circulatory system, kidneys have the task of reabsorbing useful substances like glucose, amino acids, and water.

Our digestive system works together with the urinary system and the digestive organs like a factory. How these parts work together is still not fully understood, but more detailed research has been performed and revealed more secrets of the digestive system. By means of every discovery, it is realized that this perfect creation has a more intricate structure than is known.

The brain in the intestine

There are more neurons in our intestines than in our spinal cord and the intestines are created in a way that can move independently from the central nervous system. They have their own nervous system, known as enteric nervous system (ENS), which is also called the “second brain. “Within those yards of tubing lies a complex web of microcircuitry driven by more neurotransmitters and neuromodulators than can be found anywhere else in the peripheral nervous system. These allow the ENS to perform many of its tasks in the absence of central nervous system (CNS) control…” [1]. Thus, “… isolated segments of intestine can independently coordinate propulsive movements and propel content without any neural connections to the brain or spinal cord [2].

The intestines take action when food comes into the stomach. This movement is known as colonic migrating motor complexes (CMMC), and it moves the substances that cannot be digested, like bone and fiber. According to neurophysiologist Nick Spencer et al, “The gut wall contains a complete network of intrinsic nerves capable of propelling contents along the bowel, without any requirement of nerves originating in the brain or spinal cord” [3].

Eat different types of food

70% of our immune system cells are in our intestines. A big part of the approximately 38 trillion bacteria in our body are in our intestines, and they are useful; they have a big role in digesting food. Different groups of bacteria feed on different types of food; so for intestinal flora it is very important to have a variety of food on our table. For the ideal day on a plate Dr. Megan Rossi recommends people should “aim for at least 30 different plant species per week.” “The reason for this is that each plant contains different types of fibres and phytochemicals (the super healthy components of plants) that feed different good bacteria. The more plant variety, the more variety of gut bacteria – which is associated with health and happiness” [4].

Pets in our body

For Dr. Megan Rossi, “microbes are like our pets, so you have to take care of them and feed them” [5].

Of course, germ flora in our body is not just limited to the ones in the intestines. Bacteria, viruses, and fungi in our body are nearly scattered throughout the whole body. These living things produce pellicle on our head skin, irritate the gaps between our toes, live on our skin, are on duty among our teeth, and have ecosystems and assigned positions convenient to them. According to the situation, they keep their living spaces healthy or unhealthy. Although they number 50 trillion, they are approximately 200 grams of our body weight.  

Useful microbes

An average size human adult houses about 10¹² bacteria on the skin, 10¹⁰ in the mouth, and 10¹⁴ in the gastrointestinal tract [6].

These microorganisms are useful microbes with duties in our body. The harmless flora of microbes is generally present on the skin, mouth, teeth, nose, throat, and bowel and genital areas. There isn’t normal flora in internal organs except the large bowel. Internal organs have no microbes. If we look closely, flora is inserted in every part of our body which is dirty and has contact with the outer environment. If it was not for the useful flora, microorganisms causing illness would settle instead. Only intestinal bacteria are permanent microbes which are useful. For example, vitamin K plays a part in a crucial event like blood clotting and is produced in the intestine.

Control your stress

Research has revealed that mental and psychological stress affects the health of the intestines. Serotonin is produced automatically in case of need, and 85% of it is produced in the digestive tract. Stress suppresses the level of serotonin produced. Psychological illnesses are associated with low levels of serotonin.

Studies have shown that relaxing practices like meditation for 15-20 minutes can be good for health and reduce stress. At this point, daily prayers are a kind of therapy. Other ways to stay healthy include: avoiding things like alcohol and caffeine, and sleeping well.

Our body has ways of telling us when it’s not healthy. For instance, we can learn the digestive tract isn’t healthy if we have to use the toilet more than three times a day and fewer than three times a week.

References

1. Gershon, Michael D. “The Enteric Nervous System: A Second Brain.” Pdfs.semanticscholar.org.
2. Spencer et al. 2018. “Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle.” http://www.jneurosci.org/content/38/24/5507
3. http://www.flinders.edu.au/neuroscience/lab_visceral.html
4. https://www.dailymail.co.uk/femail/article-5543159/Doctor-debunks-myths-surrounding-gut-health-say-surprise-you.html
5. https://navva.org/brazil/health/why-the-bowel-is-considered-our-39-2nd-brain-39-and-other-5-amazing-facts-about-the-organ-news/
6. http://www.textbookofbacteriology.net/normalflora_3.html

“It’s my fault, all my fault; I should’ve tried harder,” he said. A quintessential characteristic of his – always pinning the blame on no one other than himself.

They were closing us down; there was no more hope.

He had returned hopeful after the bidding: his paperwork had been in order, and he’d been at it for weeks, day and night. In fact, he hadn’t slept much since the great wave had hit them on the 16th of July. I recall seeing his worried sleepless face on the morning of the 17^th; he hadn’t slept a wink. He’d been up all night making “namaz” (prayers) for his country. He’d been confused by the events. The slowly emerging, dizzying “facts” confounded him.

The wave had been the talk of the staffroom in the days to follow. Some said that their country had just been making good progress and now everything, who knows maybe 10 or 15 years of building, had been lost, all in a single night. Teachers, first by the hundreds and then by the thousands, had been sacked, and their licenses revoked. I was shown a picture of a teacher with an angelic appearance who had been put to death because he had allegedly been involved in terrorism. The morale dropped with each passing day and the friendly smiles and warm greetings turned into frowns and drooping shoulders. I woke up each morning with a sense of angst and prayed for peace, justice, and truth to prevail in my colleagues’ country. The realization started setting in that they wouldn’t be able to return home that year. Their children would not be able to see their grandparents the next holiday. And with the school being shut down, they had no idea where to go. They told me that it’s become too dangerous to contact their families; people are being detained by the thousands. Some told me that their parents believed the news and not their own accounts of what had happened; a certain blindness had descended upon their countryfolk.

My colleagues are deeply patriotic. There were Turkish flags and laminated Turkish words labeling things and framed pictures of the Hagia Sophia and Istanbul on the walls of the school.

Talk about the failed coup eventually ceased in the staffroom and my colleagues refused to be dispirited further by it. Weeks went by and everyone kicked into survival mode. CV’s were being updated, job applications were being sent out in a frenzy, reference letters were being written, and my friends had nowhere to go. They were stranded or worse, they’d become alleged “terrorists.” My friends: terrorists? Ludicrous!

I’ve known them for over five years and the only allegation I could make against them is that they work too hard! Most work seven days a week. Our staffroom was open 24 hours and I’d often see them working in there as late as 11 at night. They had once compelled me to redo a video promo I’d made about the school just to insert a clip of the Prime Minister at the time, Erdoğan, and his wife who had attended a Turkish Olympiad (Türkçe Olimpiyatları) where Ghanaians had performed a traditional Turkish dance. Both Erdoğan and his wife were deeply touched. I’m not sure if I had gotten my facts straight… so he, Erdoğan, was blaming my colleagues of plotting against him? The reasoning behind this had confounded myself and my colleagues alike.

They’ve travelled land and sea to make other nations pro-Turkish and pro-Turkey. Never had I picked up on an ounce of resentment against Turkey from my devoted colleagues.

And when my colleague had exerted his final efforts and realized that the fight to keep the school open had been lost, he sighed and said: “It’s my fault, all my fault; I should’ve tried harder.” My heart broke upon hearing these words uttered by a man who teaches his students on weekends and until eleven o’clock at night to help prepare them for their exam the next day. My heart was shattered when I heard those words from the man who had learned to push on with his teaching responsibilities despite an onslaught of dengue fever, his shirt completely soaked and his eyes deeply sunken.  “You should rest Abi,” I said to him. “I will rest in the hereafter,” he stoically replied.

My heart was crushed when he still blamed himself when powers beyond his control had worked against him, the man who had once removed the tie from his neck and wrapped it up neatly and made it a gift to me following my comment about its beauty. How can my heart go on if the man – who took me to his unfurnished house, save for a mattress on the floor, to give me his own mattress when mine was infested with bed bugs – is labelled a “terrorist”? Tell me, how should I respond? What should I do to convince people that none of this is his fault, that he’s a man of peace, a teacher by trade and nothing more, that he’s nothing less than a saint? Tell me, what should I do?

For nearly a century, chlorine has been used to disinfect drinking water. The use of chlorine in water started when John Snow used to purify the cholera-causing water of the Broad Street Pump, in London. After seeing that chlorine curbed deaths from cholera, Great Britain started chlorinating their public drinking water. Then chlorination began in New Jersey, and after that it was soon used throughout the United States. Measuring the benefits and risks, it’s clear that the advantages of adding chlorine to drinking water outweigh the potential dangers. Scientific research also shows that the benefits of chlorinated water are more than the risks from THM’s and other by-products (Health Canada, 2004).

There continue to be many people in developing countries who do not have access to clean water. In some parts of the world, people collect water from available sources and store it in containers without treatment and further protection from contamination (Sobsey, Handzal & Venczel, 2003).

Sobsey, Handzal & Venczel (2003) conducted an experiment to see the effects of chlorine when added to a container with contaminated water. These experiments were conducted in Bangladesh and Bolivia. Community families were divided into two groups: intervention (household water chlorination and storage in special container) and control (no intervention). The results in Bangladesh were: in the intervention households, only 12.9% of the containers were E.coli positive; in the control households, 55.2% of containers were E.coli positive. The results were equally stark in Bolivia: only 33.7% of intervention households were contaminated by E.coli, whereas 93.8% of control households were contaminated.

There was also a decrease in the diarrhoeal illness in the experimental findings for samples in both countries’ households where the water was treated with chlorine. During the eight-month trial period, the mean diarrhea incidence rates of children younger than five years old in Bangladesh was 20.8 episodes/1000 days in the intervention group and 24.3 episodes/1000 days in the control group. In Bolivia, where the experiment lasted for six months, the mean diarrhea episodes/person for all age groups was 0.21 for the intervention group 0.38 for the control group. 43% of all cases of diarrhea were preventable by the intervention (Sobsey et al., 2003).

The study noted other successes. In some countries, like Saudi Arabia, chlorine was used in household tanks, which resulted in a 48% reduction of diarrhea; and in India, chlorine was used in earthenware, which resulted in a decrease of cholera cases, from 17% to 7.3%. (Sobsey et al., 2003).

In another study, Coulliette, Enger, Weir & Rose (2013), evaluated the effect of chlorinated HaloPure beads on the reduction of bacterial pathogens with concurrent sewage contamination. They estimated the risk reduction of waterborne typhoid fever and cholera within a hypothetical community of 1000 people treating their water with the chlorinated HaloPure beads. Seeded well water resulted in log10 reductions of 5.44 for S. Typhi and 6.07 for V. cholera (Coulliette et al., 2013). In well water with 10% sewage and seeded bacteria, the log10 reductions were 6.06 for S. Typhi and 7.78 for V. cholera (Coulliette et al., 2013). If an individual drinks from the contaminated water that was taken from the water source that had fecal material leaked into it, the risk of disease according to the Monte Carlo analysis would be a median of 0.21 for typhoid fever and a median of 0.11 for cholera (Coulliette et al., 2013). If that same water was treated, then the result would be: median of 4.1*10^-7 for typhoid and a median of 3.5*10^-9 for cholera (Coulliette et al., 2013).

These are important results: in developing counties, diarrhea is one of the greatest health issues. Arnold & Colford JR. (2007) conducted a systematic review of all studies that measured diarrheal health impacts in children and the impact on water quality of point-of-use chlorine drinking water treatment. Of the 10 studies that were analysed, nine of them showed a reduction of diarrhea in children. Across the 10 studies, the intervention led to an 80% reduction in the proportion of stored water samples with detectable E. coli (Arnold & Colford JR, 2007).

Water chlorination has been a very useful strategy for treating contaminated water for years. Currently, chlorination is the only method that disinfects the pathogens from the point of treatment to the point of consumption. As the scientific research above indicates, the benefits of chlorinating water supplies, particularly in the developing part of the world, is essential for disease prevention and reduction. Water is an essential element for life, and clean water is what keeps us alive. Although chlorine in large doses can be harmful for our health, it can also be a lifesaver. Nothing on earth is created without reason. Chlorine has obviously been created to directly benefit humanity.

References

• Arnold, B. F., & Colford JR., J. M. (2007). Treating water with chlorine at point-of-use to improve water quality and reduce child diarrhoea in developing countries: A systemic review and meta-analysis.The American Society of Tropical Medicine and Hygiene, 76 (2), 354-364.
• Coulliette, A. D., Enger, K. S., Weir, M. H., & Rose, J. B. (2013). Risk reduction assessment of waterborne Salmonella and Vibrio by a chlorine contact disinfectant point-of-use device.International journal of hygiene and environmental health,216(3), 355-361.
• Sobsey, M. D., Handzel, T., & Venczel, L. (2003). Chlorination and safe storage of household drinking water in developing countries to reduce waterborne disease.Water science and technology : a journal of the International Association on Water Pollution Research, 47 (3), 221-228.
• It’s Your Health – Drinking Water Chlorination [Health Canada, 2004]. (n.d.). Retrieved June 5, 2013, from http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/environ/chlor-eng.php

Hayah, which can be translated as liveliness and being alive, means that a heart which is already dead because of ignorance, misguidance and unbelief, comes to life through belief, and knowledge and love of God. The verse (6:122), He who was dead (in spirit), and We raised him to life, and set for him a light by which he moves among people without any deviation, makes this point clear.

The scholars of truth regard life as being when one is freed from the imprisonment of the body and corporeality and rises to the level of the life of the heart and spirit. The aspect of this favor which is represented by the master of the creatures, upon him be peace and blessings, who, although an individual, gained universality, can be seen in the verse (42:52), Thus, We have revealed to you from Our (world of) Command (the Qur’an as) a spirit (promising life to the hearts). The aspect which concerns all others who promise life is indicated in the verse (8:24): O you who believe! Respond to God and to the Messenger when the Messenger calls you (in the name of God) to that which gives you life (with respect to the religion and the world).

The life of the earth, with all its revival and instances of growth and flourishing, is essentially related to the soil and its content, water with its vitality, air and the gases contained in the air. Similarly, true human life is dependent on the knowledge of truth, a strong will-power and endeavor, a sound character and good morals, a deep desire for God’s company, and rejoicing at the awareness of such a great favor. All these together serve as a runway or ramp from which to rise up to the realm where souls fly and attain the eternal life.

The earth derives all its riches from the source described in (16:65): God sends down from (the direction of) the sky a kind of water and therewith revives the earth after its death; in (50:11): We have revived with that water a dead land, and so is coming forth (from the graves); and in (21:30): We have made every living thing from water. Likewise, dead souls exposed to a dearth of faith, and lack of knowledge and of love of God, are revived through belief; they begin to feel what life really means through their knowledge of God, they dive into its depths through love, and attain a full life through resolution, will-power and determination. Then, as long as initiates realize the goal of Follow God’s way of acting [1] under the guidance of the supreme exemplar of good morals, the one who is praised in the verse (68:4), Surely You stand on an exalted standard of character, they attain God’s company in the infinite air in which they beat their wings, and feel constant gratitude and enthusiasm. When the time is due, they feel so expanded with the rapture of being in God’s presence that it is as if they transcended the limits of time and space and been favored with the rank, When I love My servant, I become his hearing with which He hears and his sight with which he sees and his hand with which he holds and his feet on which he walks [2]. And as stated in (56:89): Then (there is for him) comfort in eternal relief, and abundance, and a Garden of bounty and blessing, their spirits continue, by the Power of the All-Powerful Sovereign, flying toward eternity in the Gardens of Paradise, the Presence of the Lord of the worlds, and the company of the Most Compassionate of the compassionate.

In this rank, which is the essence of true life, there is neither death nor decay. Death and decay only occur with respect to the carnal soul and corporeality, and there is permanence with respect to the heart, spirit and other spiritual faculties. This permanence is also viewed as “self-annihilation in God” and “subsistence by Him and with Him.”

There are three breaths in the life of an initiate who has reached this degree: the breath of fear, the breath of expectation, and the breath of love. As the carnal soul fulfils an important mission on behalf of corporeality and the body, fear, expectation, and love are each an important dynamic for the life of the spirit and heart. Always feeling fear and love of Him causes the conscience of the initiate to feel an overflowing pleasure by far greater than what a child feels upon seeking refuge in the arms of the mother who has just chided him. Thinking of Him as the All-Compassionate, All-Loving Lord, and considering the depth of His Mercy, is such a spiritual pleasure that if it were to take on a physical form, it would appear like a Garden of Paradise. Finding or reading His Names on the face of His works, breathing His Attributes on the climate produced by the manifestations of His Names, and feeling the pleasure embedded in wonder at the consideration of the relation between His works, Names and Attributes, gives such an indescribable pleasure that only those who have been able to realize this degree of spiritual ascension can feel it.

Those who can most swiftly reach this most precious goal, even though they are unable to feel the grace of this sacred journey at every step, are those who set off by being able to ac-knowledge their poverty and helplessness before God, and their gratitude and enthusiasm. They know how to become an ocean while each of them is still a drop; they know how to travel among galaxies while each is still a particle, and although they see themselves as nothing, they are able to live in the wheel of existence in accordance with its ultimate goal. They always travel saying, as Ibrahim Haqqi said:

I have attained pride through poverty,
and supplicating to the Ultimate Truth,
I always utter, O the All-Living, O the Self-Subsistent!

They overflow with enthusiasm and gratitude, and are enraptured with the lights of the true life and existence, which are found a step beyond this horizon. Without considering the assertions of some, such as the Unity of Being and the Unity of the Witnessed, they feel the truth of life and existence beyond all conceptions of modality, and say: This life is not sufficient for such an expanse of pleasure.

O God! Guide us to the Straight Way, the way of those whom You have favored. And bestow peace and blessings on the master of the creatures, the means of the life of the two worlds, and on his Family and all of his Companions, all of them.

References

1. al-Jurjani, at-Ta‘rifat, 1:216.
2. al-Bukhari, “Riqaq,” 38.