When we get a prescription from a doctor, the drug usually comes with instructions for how to use it. These include when we take the drug (before or after a meal), how many times a day and for how long we take it, and what we have to avoid while using the drug. Doctors also ask if we use any other medication or if we have any chronic disease before prescribing any new medication. Most medicines look similar, but drugs themselves can be very different. Have you thought about what happens to a drug when it gets into our body?

All body functions and disease processes—as well as most drug reactions—occur at the cellular level. Drugs are chemicals that alter basic processes in body cells. They cannot add functions and activities but can only affect normal cellular functions and activities. Drugs given for systemic effects must reach adequate concentrations in the blood and other tissue fluids surrounding our cells to have an effect. Drugs must circulate through their body, reach their intended cells, and, after affecting the cells, be eliminated from the body. But how do all these processes occur? How do systemic drugs reach, interact with, and leave the body’s cells?

The answers to these questions are answered by one of the main domains of pharmacology—pharmacokinetics. Pharmacokinetics is derived from the Greek words pharmakon (drug) and kinetikos (movement) and means “what the body does to a drug.” It refers to the movement of a drug into, through, and out of the body.

Knowledge of pharmacokinetic principles helps healthcare providers to adjust dosages more accurately and rapidly. Application of pharmacokinetic principles to individualize pharmacotherapy is termed therapeutic drug monitoring and aims to give the exact amount of drug to each person.

The four main parts of the pharmacokinetic processes are

• Absorption
• Distribution
• Metabolism
• Elimination

These processes are abbreviated as ADME.

Figure. Entry and movement of drug molecules through the body to sites of action, as well as metabolism and excretion 

Absorption

Absorption is the process that occurs when a drug enters the body until it enters the bloodstream to be circulated. The duration of a drug’s action is largely determined by the rate of absorption, and intensity is determined by the extent of absorption.

Numerous factors affect the rate and extent of drug absorption, including dosage, form, route of administration, blood flow to the site of administration, gastrointestinal function, and the presence of food or other drugs.

Most oral drugs must be swallowed, dissolved in gastric fluid, and delivered to the small intestine (which has a large surface area for absorption of nutrients and drugs) before they are absorbed. Liquid medications are absorbed faster than tablets or capsules because they need not be dissolved. Rapid movement through the stomach and small intestine may increase drug absorption by promoting contact with absorptive mucous membrane; it also may decrease absorption because some drugs may move through the small intestine too rapidly to be absorbed. For many drugs, the presence of food in the stomach slows the rate of absorption and may decrease the amount of drug absorbed. That is why some drugs are taken before meals and some after.

Drugs cannot be absorbed well when a patient has diarrhea and the intestines are working excessively; the effect of the drug will be reduced. Absorption may be increased if the patient has constipation and the intestines are working very slowly; this could have unforeseen adverse effects.

Drugs injected into subcutaneous (under the skin) or intramuscular (in the muscles) tissues are usually absorbed more rapidly than oral drugs because they move directly from the injection site to the bloodstream. Absorption is rapid from muscle sites because muscle tissue has abundant blood supply. Drugs injected intravenously (into the veins) do not need to be absorbed because they are placed directly into the bloodstream.

Other absorptive sites include the skin, mucous membranes, and lungs. Most drugs applied to the skin are given for local effects (e.g., muscle relaxant creams, itch relief ointments, and burn ointments). Systemic absorption is minimal from intact skin but may be considerable when the skin is inflamed or damaged. Also, a number of drugs have been formulated in adhesive skin patches for absorption through the skin. Some drugs applied to mucous membranes also are given for local effects. However, systemic absorption occurs from the mucosa of the oral cavity, nose, eyes, etc. Drugs absorbed through mucous membranes pass directly into the bloodstream. For example, nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have coronary artery disease. It is also used just before activities that may cause episodes of angina to prevent symptoms. It works by relaxing the blood vessels so the heart does not need to work as hard and therefore does not need as much oxygen. The lungs can be a good absorption site, as they have a large surface area for absorption of anesthetic gases and a few other drugs.

Distribution

Distribution involves the transport of drug molecules within the body. Once a drug is injected or absorbed into the bloodstream, it is carried by the blood and tissue fluids to its sites of pharmacologic action, metabolism, and excretion. Most drug molecules enter and leave the bloodstream at the capillary level, through gaps between the cells that form capillary walls.

Distribution depends largely on the adequacy of blood circulation. Drugs are distributed rapidly to organs receiving a large blood supply, such as the heart, liver, and kidneys. Distribution to other internal organs, muscle, fat, and skin is usually slower.

An important factor in drug distribution is protein binding. Most drugs form a complex with plasma proteins such as albumin. These proteins act as carriers for the drugs. Drug molecules bound to plasma proteins are pharmacologically inactive because the large size of the complex prevents their leaving the bloodstream through the small openings in capillary walls and reaching their sites of action. Only the free or unbound portion of a drug acts on the body’s cells. As the free drug acts on cells, the decrease in plasma protein levels causes some of the bound drug to be released.

Protein binding allows part of a drug dose to be stored and released as needed. Some drugs also are stored in muscle, fat, or other body tissues and released gradually when plasma drug levels fall. These storage mechanisms reduce the risk of toxicity. Drugs that are highly bound to plasma proteins or stored extensively in other tissues have a long duration of action. This affects the frequency of intake of a drug and is why some drugs are taken more frequently.

Drug distribution into the central nervous system (CNS) is limited because of the blood–brain barrier, which is composed of capillaries with tight walls and limits the movement of drug molecules into brain tissue. This barrier has been created to act as a selectively permeable membrane to protect the CNS. However, it also can make drug therapy for CNS disorders more difficult because drugs must pass through the cells of the capillary wall rather than between cells. As a result, only drugs that are lipid soluble or have a transport system can cross the blood–brain barrier and reach therapeutic concentrations in brain tissue.

Drug distribution during pregnancy and lactation is also unique. During pregnancy, most drugs cross the placenta and may affect the fetus. During lactation, many drugs enter breast milk and may affect the nursing infant. This barrier is also important and protects the fetus from the adverse effects of drugs.

If we have valuable things at home or at work, we put them in extra safe places and use extra security systems to protect them. So it is with our body: our brain and a fetus are extra protected by these barriers.

Metabolism

Metabolism is the chemical reaction by which drugs are inactivated or bio-transformed by the body. Most often, an active drug is changed into one or more inactive metabolites, which are then excreted. Some active drugs yield metabolites that are also active and that continue to exert their effects on the body’s cells until they are metabolized further or excreted. Other drugs (called prodrugs) are initially inactive and exert no pharmacologic effects until they are metabolized.

Most drugs are lipid soluble, a characteristic that aids their movement across cell membranes. However, the kidneys, which are the primary excretory organs, can excrete only water-soluble substances. Therefore, one function of metabolism is to convert fat-soluble drugs into water-soluble metabolites.

Hepatic drug metabolism—or clearance—is a major mechanism for terminating drug action and eliminating drug molecules from the body. Most drugs are metabolized by enzymes in the liver, red blood cells, plasma, kidneys, lungs, and gastrointestinal mucosa.

With long term administration, some drugs stimulate liver cells to produce larger amounts of drug metabolizing enzymes (a process called enzyme induction). Enzyme induction accelerates drug metabolism because larger amounts of the enzymes allow larger amounts of a drug to be metabolized during a given time. As a result, larger doses of the rapidly metabolized drug may be required to produce or maintain therapeutic effects. Metabolism also can be decreased or delayed in a process called enzyme inhibition, which most often occurs with concurrent administration of two or more drugs that compete for the same metabolizing enzymes. In this case, smaller doses of the slowly metabolized drug may be needed to avoid adverse reactions and toxicity from drug accumulation. Thus, doctors always ask about any medications already being used before prescribing a new medication. Also, some foods (eg. grapefruit), drinks (alcohol), and smoking affect the activity of the enzymes which are metabolizing the drugs in the liver. Thus, we must be careful and follow a doctor’s instructions while using any medication.

The rate of drug metabolism is also reduced in infants (their hepatic enzyme system is immature), in people with impaired blood flow to the liver or severe hepatic or cardiovascular disease, and in people who are malnourished or on low-protein diets. Metabolism in  elderly people and pregnant women also changes a lot; thus, the dose given to each individual should be carefully calculated—especially in children, the elderly, and pregnant women.

Excretion

Excretion refers to the elimination of a drug from the body. Effective excretion requires adequate functioning of the circulatory system and of the organs of excretion (kidneys, bowel, lungs, and skin). Most drugs are excreted by the kidneys and eliminated unchanged or as metabolites in urine. Some drugs or metabolites are excreted in bile, then eliminated in feces; others are excreted in bile, reabsorbed from the small intestine, returned to the liver (called enterohepatic recirculation), metabolized, and eventually excreted in urine. Some oral drugs are not absorbed and are excreted in the feces. The lungs mainly remove volatile substances, such as anesthetic gases. The skin has minimal excretory function. Factors impairing excretion, especially severe renal disease, lead to accumulation of numerous drugs and may cause severe adverse effects if dosage is not reduced. Doctors always ask about any chronic diseases before prescribing any medication.

The process of developing a drug is long and difficult. The instructions for usage are decided after many experimental and clinical trials. None of the instructions given with medications are decided randomly; thus, we must completely follow the instructions to maximize the positive effects of a drug and to avoid any possible adverse effects.

References

• Abrams, Anne Collins., Carol Barnett Lammon, and Sandra Smith Pennington. Clinical Drug Therapy: Rationales for Nursing Practice. 7th ed. Philadelphia: Lippincott Williams & Wilkins, 2007.
• Basic&Clinical Pharmacology, 12^th Edition, McGrawHill Lange.
• Modern Pharmacology with Clinical Applications, Sixth Edition, Charles R. Craig and Robert E. Stitzel, Lippincott Williams &Wilkins.

In the language of Sufism, farq (distinguishing) has been interpreted as making a clear distinction between unity and multiplicity. To give a longer and more explicit definition, distinguishing means the discernment of the created, despite having perfect knowledge of the Creator, and despite being among people at the same time as being in God’s company. Absorption is marked with knowledge and love of God the Almighty and spiritual pleasures, while it is a distinctive sign of distinguishing that an initiate who has it tries to lead others to the same horizon of knowledge and love of God and spiritual pleasures. For this reason, it has been said that one who does not have distinguishing is imperfect in servanthood to God, and one who does not feel absorption lacks in perfect knowledge of God. This is why one should have both distinguishing and absorption, each of which has a significance of its own. As mentioned before, in the account of absorption, You alone do we worship (1:5) is said to indicate distinguishing, and You alone do we ask for help (1:5) absorption.

Absorption is a subjective state of pleasure, while distinguishing is objective and occurs totally based on the Shari‘a. In absorption, one is under a greater influence from one’s spiritual state and inner depth than from one’s reason and logic, but in distinguishing, reasoning according to the Shari‘a is essential. One can pass into the state of absorption from the state of distinguishing. However, to turn back to the latter from the former means becoming distinguished. Those who remain in absorption are immersed in spiritual pleasures according to the capacity of their spirits and know nothing else. Isa Mahwi expresses this as follows:

One who exists in his non-existence
does not know non-existence while he exists;
Strangers to this state are unaware of the pleasure
in communion with the Beloved.

If one remains in the rank of absorption and is unable to turn back to distinguishing, this means that one has not been able to perceive well what Prophethood is. Ascending is progress, but descending among people after having completed ascension is perfection. An initiate has individual pleasure in absorption and can be an individual mirror to the Divine truths, but distinguishing after absorption denotes a determined attitude, pleasure shared with others and it denotes serving as a comprehensive mirror. Those who have attained such a station are with God and with people; and they discern Him in His manifestations in everything, feel unity in multiplicity, and look at multiplicity from and through unity.

Concerning the relation between distinguishing and absorption, we should also point out the “differentiation in absorption.” This means that heroes of spiritual state and pleasures can discern and observe the All-Holy One Who manifests Himself differently in different mirrors. As for the differences among the mirrors—things or beings and events that receive and reflect God’s manifestations—these are caused by the varying capacities of the mirrors to receive the manifestations.

Distinguishing after absorption is a more sound and perfect state than the former one—distinguishing before absorption. It is the state in which travelers to God cut their heart-felt relations with all else save the Single, Unique One and completely turn to Him to be annihilated in Him. Like annihilation in God and subsistence by God, those who have attained this rank do not discern the world and the things in it, although these exist before their eyes. They live in immersion, with observations made with their insight into the Divine Attributes and Essential Qualities in all things and events, and are lost in the manifestations of unity in the mirrors of multiplicity. Like the stars, which, although they are always there, become invisible when the sun rises—we should set forth for God the most sublime of examples—the heroes of this rank cannot see anything else other than Him from their observatory in the atmosphere of the manifestations of the Essential Qualities and Attributes of the Holy Existence Who is manifest enough to be recognized before all else.

From another perspective, an initiate in absorption is freed from corporeality and the animal dimension of his or her being, or dies with respect to his or her carnal ego, while in distinguishing he or she rises to the level of life that is lived at the level of spirit and heart and gains a new existence with an ego refined or restored by the All-Merciful. In this rank, he or she confesses, “I have lost my carnal ego and attained a new ego from the All-Merciful,” and always expresses the fact that “There is no agent save God,” without excluding the part of their free will in their acts. Being aware of the realities of the Existence and Knowledge that are contained in the degree of certainty based on experience, he or she is enraptured with the observation of the dominion of the All-Living, Self-Subsisting One over everything.

We should point out that, despite all considerations of annihilation and ecstasy, distinction is essential to distinguishing. Heroes of distinguishing are alert at every step of their journey to the fact that, though it is the Creator of causes alone Who creates both humanity and their deeds, they have free will, even though it consists of a relative inclination. They remain mindful that they have been given free will so that they are responsible and accountable for their sins and errors.

With respect to distinguishing, some people have gone to extremes and become mired in deviations. According to these people—may God protect us from believing in such a thing—every person is the creator of his or her own deeds, and human free will has an absolute effect on human actions. Some others hold exactly the opposite view and assert that human free will can play no part in human actions at all in the face of the absolute Divine Will. They suppose that human beings are like dried leaves blown around by winds in the face of an overwhelming, all-compelling will. Those who have adopted the Straight Way, and who have been favored with true perception of the mystery of the Divine Will in Its relation with human free will, have admitted that everything occurs by God’s Will and Power without human free will being excluded. God takes human inclinations or free choice into consideration when determining and creating the actions of humans. Such a belief supports with prayers their inclinations to do good, while also helping them to struggle against their inclinations to do evil by asking God for forgiveness.

The first of the three groups mentioned generally consist of naturalists, materialists and some rationalists who attribute every thing and every event to “natural” causes. They do not admit that anything else exists except what they can see with their eyes and hear with their ears.

Overpowered by the spiritual state in which they find themselves and the pleasures they feel, the second group negate free will and display fatalism, making out that people are like senseless objects.

As for the third group, in addition to seeing God’s Wisdom and authority, creativity and disposal in everything, in their consciousness that stems from their belief, and with their conscious perception, they admit that they have been endowed with a free will, which in reality consists in an inclination. So, without ever confusing the parts of the Divine Will and their own choices with each other in their acts, they are aware of what is meant when they say “I have done it.” In whatever kind or degree of pleasure and immersion they find themselves, they never lose their conviction of this fact.

Our Lord, do not let our hearts swerve after You have guided us, and bestow upon us mercy from Your Presence. Surely You, only You, are the (Munificent) Bestower. And bestow blessings and peace on our master Muhammad, the master of those who ever turn to God in contrition, and on his Family and Companions, the noble, honorable and godly ones.

Absorption can never mean the unity of being—the unity (union) of God and the universe or God’s being identical with the universe—in the sense that pantheists claim, nor is distinguishing totally its opposite. The One Who is the Eternal (beyond all time and space) is eternal, and the beings who are contained in time and come into existence within time are mortal and different from the Eternal One. The Creator cannot be and is not the same as the created. The relation between them is not that which comes from appearance; that is, the universe is not an apparent form of God. Rather, this relation is that between the Creator and the created. We can also see the creation as the totality of the manifestations of God’s Names. These manifestations are completely pure and transparent, while that which issues from the created is usually tangible. Human beings have both a pure, transparent aspect or dimension, and a dense/tangible one.

This is why, as declared in the verse (17:84), Each being acts according to his own standard of measure, they can display behavior either according to their bodily dimension or according to their spirit. As they are made up of a body and a carnal soul, they fix their eyes on nature and corporeality, while they carry inclinations toward spiritual, exalted worlds as well because there is an immaterial spirit in their composition. By means of the ways of rising which the Shari‘a has appointed and guaranteed, travelers on the way to God cut their relations with fleeting and decaying things and turn to eternity. As described in Is he whose breast God has expanded and opened to Islam, so that he follows a light from his Lord…? (39:22), when travelers to God turn to Him in submission, they travel in the exhilarating horizons with utmost self-possession and awareness under the guidance of the light of their Lord. Even though they may sometimes encounter confusion or bewilderment, they easily overcome these with the assistance of the never-deceiving leadership of the master of creation (Prophet Muhammad), upon him be peace and blessings. They always head for the sources of knowledge that God has determined and secured through Prophethood, and never err as some pantheists do.

From another perspective, absorption has been dealt with under the rubrics of “absorption with respect to knowledge,” “absorption with respect to existence,” and “absorption with respect to the (Divine) Being Himself.”

“Absorption with respect to knowledge” means that at the beginning of their journey, travelers to God base themselves on the knowledge that comes from, or that is obtained through, the proofs and indications of God. Then this knowledge develops from the certainty based on knowledge into a certainty based on observation and finally into a certainty based on experience. However, only a shadowy degree of certainty based on experience can be reached in the world. Ultimately, this knowledge becomes pure knowledge from His Presence. Although it is the result of following the way of inference, it is not the same as the knowledge acquired through proof originated in the outer world or in the human inner world. Not is it totally different either. It is a special gift of the Almighty to the proper use of the free will with which God has endowed human beings, and which is in fact a simple means given to them for the execution of the Divine commandments. However, like all other Divine gifts, this gift is never proportionate to our free will. Like it, all other gifts of God Almighty are many times greater than what we actually deserve.

“Absorption with respect to existence” is when the travelers to God are perfectly aware in their consciousness of how things and events occur and how they are maintained. All of existence disappears from their vision to the extent that they are no longer aware of which direction is right and which is left. Heroes of the spiritual life, who have stepped into this station, feel only the rays of the Eternal All-Holy Existence and Knowledge and see all else as the motions of these rays. Provided manifestation is not confused with appearance, and shadow with the original, those who have attained this horizon feel or hear innumerable things and/or beings in every part of the universe invoking His Name, saying, He is the Ever-Living, the Self-Subsisting (by Whom all subsist) (2:255).

“Absorption with respect to the (Divine) Being Himself” means that all the indications and proofs of God that originate in the outer and inner human world are no longer visible in the face of the light of knowledge of God and the spiritual pleasure that the Almighty lets flow into the hearts of travelers to Him. Some have regarded this rank as the final station of the spiritual journey. If they base this consideration on constant turning to God during traveling from wakefulness to self-possession and thence to repentance, penitence and contrition one after the other, and on the relation between God and humankind as being the relation between the Creator and the created, and the Sole Object of Worship and the worshipper, and the Lord and the servant, there can be no objection. But, if they imply by absorption that things have no reality at all, and it is of no use or significance to use one’s mental faculties to infer from things and events the existence of God and therefore to acquire certain knowledge about Him, and that people are no longer responsible for the fulfillment of religious obligations after reaching some point in the spiritual journey, and that there is essentially no difference between I and you and He, then this is most definitely a total deviation in conception and creed. This can be either a fantasy of those who are pursuing “originality” for the sake of fame or a view held by some self-conceited pantheists and monists.

As for the Prophets and the pure, saintly scholars, they have regarded the way leading to the Infinite One as endless, and have experienced the final station one can reach in the journey along this way according to their capacity with the same solemnity, wakefulness, and consciousness as they experienced in the beginning. They have always accepted that serving the Ultimate Truth with the utmost humility is the goal of their lives. The Almighty ordered the master of creation (Prophet Muhammad), the most perfect in servanthood to Him, Worship your Lord until certainty, which is bound to come, comes to you (15:99). By this, together with ordering him to worship Him until death comes to him, He both emphasizes that death marks the end of this responsibility and consoles the Messenger for the afflictions and tortures he was subjected to by reminding him of his meeting with God. Because meeting with God meant for him reaching certainty based on experience in his own, unique level.

O God! Include us among Your servants sincere (in faith and practicing the religion), and endowed with sincerity, and God-revering, pious, and abstinent from all forbidden things big or small, and among those of ascetism and those near-stationed to You, and who are pleased with You and pleasing to You. And bestow blessings and peace on our master Muhammad, the leader of the God-revering, pious and the leader of those endowed with sincerity, and on his Family and Companions, those of ascetism and those near-stationed to You, and who are pleased with You and pleasing to You. Amen!

Jam‘ (absorption) literally means coming and bringing together. In the language of Sufism, it means fixing all one’s feeling, sight and consciousness on the Ultimate Truth, to the extent that one is absorbed in Him and does not feel the existence of the world with all that is in it. To the degree of one’s knowledge of God, one only knows Him, feels Him, sees Him and is saved from preoccupation with anything else. If this meaning is approached from the concept of unity, it is the opposite of multiplicity; but if it is conceived of as one’s heart cutting off relations with all else save God, then its opposite is distinguishing (farq), which we, God willing, will deal with as a separate subject.

Absorption is a state or station belonging to those who have reached the final state of the spiritual journey. Travelers to the Ultimate Truth who are honored with the gift of absorption always feel Him, know Him, and according to the level of the horizon and spiritual pleasures of each, can be aware or not aware of the people around them. But they always feel and are always conscious of the Ultimate Truth and live as if charmed by observation of the meanings that belong to Him and that are reflected in everything. They always see the manifestations of His Names and Attributes in all things and events which they encounter. Thirsty for the Divine Being Himself, they fly around the manifestations of His “Facial” Light like moths flying around a light. In tides of wonder and admiration, they cannot help but utter: All-Glorified are You, how exalted You are (as the Divine Being)!

Two steps further from this state of pleasure is absorption within absorption, which means a total absence for initiates. Travelers who find themselves in such a whirlpool of feeling are no longer aware of their own selves nor that of others. Totally detached from distinguishing, they are completely forgetful of all else save the Ultimate Truth—as anybody except He is a shadow of the shadow of the light of His Existence—and turn to Him with all their being.

For initiates who base themselves on absolute unity in all their views and considerations, everything is a shadow of the light of the Existence of the Ultimate Truth. For one who is in the state of absorption, it is a shadow of the shadow of His Existence’s light, while one who is in the absorption within absorption only sees the rays of the manifestations of His “Facial” Light in the name of the creation. Some scholars mention a further degree of absorption, which they call holy absorption. This is the rank which the verifying scholars of Sufism regard as the title of nearness to God, Who is nearer to us than ourselves, by means of supererogatory prayers. The travelers who have attained this level are conscious that it is God Who maintains them, and begin to observe everything more deeply and clearly with their innermost senses, which have become sharper than their external senses. They hear with their spirit, see with their power of insight, review and examine with their conscience, and have the ability to see the true faces of theoretical knowledge through the door half-opened through their inner vision and experience. This is the rank where travelers are favored with the full manifestation of the truth contained in He is the First, and the Last, and the All-Outward, and the All-Inward (57:3), and where they become polished mirrors that reflect it. The servants of God who have reached this farthest point either “travel in God” and rotate around themselves like the North Star, or are turning around their axis in their hearts while being in their bodies among people.

Those who have attained the rank of absorption have also been favored with “subsistence by God.” Those who hold this rank in the final stage of the journey, and who are abstracted from their own attributes in their absorption in God’s Attributes and from their own being in absorption in God’s Being, gain a new existence through subsistence by God. They begin to feel the bliss of eternality and breathe “absorption” in the delight of being aware that their acts have become lost in God’s Acts. A stage further, which can be likened to deepening in worship by bowing down after standing in the Prayer, and when they observe that their attributes have been annihilated in the all-comprehensive Attributes of God, they become lost in the delight of experiencing absorption within absorption. Finally, as a result of their own being being obliterated in the face of God’s Knowledge and Existence, they leave themselves to the consideration of the holy absorption with inner vision and spiritual pleasures, and are immersed in the feelings of wonder upon wonder.

From another point of view, the act of observing the requirements or responsibilities of servanthood to God with the utmost care, devotion, and consciousness is called “distinguishing,” while being favored with a shower of Divine gifts that come “from where they do not reckon” as a reward for this “small capital”—small in the face of God’s favors coming without reckoning—is absorption. In view of this approach, heroes of the spiritual state say that one who does not perceive “distinguishing” is ignorant of servanthood, while one who does not feel absorption is unaware of knowing God.

The Qur’anic statement (1:5), You alone do we worship, which expresses the individual consciousness developing into and translating the public consciousness, is a voice of distinguishing and servanthood, while You alone do we ask for help (1:5) is an expression of absorption and a declaration of human poverty and helplessness before God. Every initiate hears the voice of distinguishing at the beginning of the spiritual journey and feels the pleasure of absorption at the end of it. The ultimate point, which only those endowed with a particular capacity can reach, is “absorption within absorption” and the “holy absorption.” While the former signifies the rank of ahadiya (feeling God’s absolute Oneness in the sense of His concentration of the manifestations of His Attributes and Names on things or beings individually), the latter is a sign of the peak of wahidiya (feeling God’s absolute Unity in the sense of His manifestation of His Attributes and Names throughout the universe).

According to al-Kashani, [1] distinguishing is the knowledge of God the Almighty and spiritual pleasures of those who have not yet been able to develop their theoretical considerations about God (I personally find this view unacceptable), while absorption is immersion caused by a concentration on the Creator without ever thinking of the creation, and absorption within absorption is the peak of seeing the creation as subsisting by the Creator. This final rank is also the rank of distinguishing above absorption. Since in this rank only God’s Acts, Attributes and Essential Qualities are observed, for those who have attained this rank, the All-Holy, Ultimate Truth becomes the eyes with which they see, the ears with which they hear, and the hands with which they hold. For this reason, He attributes to Himself what they do with their free will and leave and ignore the apparent causes. The Sufi scholars are of the opinion that the verse, (8:17), You did not kill them but God killed them, and when you threw, it was not you who threw, but God who threw, besides clearly mentioning a miracle of God’s Messenger, upon him be peace and blessings, alludes to this rank.

O God! Include us among Your servants sincere (in faith and practicing the religion), and endowed with sincerity, and God-revering, pious, and abstinent from all forbidden things big or small, and among those of ascetism and those near-stationed to You, and who are pleased with You and pleasing to You. And bestow blessings and peace on our master Muhammad, the leader of the God-revering, pious and the leader of those endowed with sincerity, and on his Family and Companions, those of ascetism and those near-stationed to You, and who are pleased with You and pleasing to You. Amen!

Some medications are effective directly over the area they are applied to. Some however are transported to distant regions via blood flow and that is where they are most effective. Medication is either taken orally or through injection. When medicine passes into the blood stream from the place of administration, it is considered to be absorbed. A good example is the transportation of medicine into the blood stream of capillary vessels between the muscle cells when injected into muscle tissue. A drug taken orally however is absorbed through the blood vessels in the gastro-intestinal system.

For orally-taken medication to be absorbed, it should be able to dissolve in gastro-intestinal fluids. First, it is broken into smaller units due to the corroding effects of stomach acid and various enzymes are secreted, then chemicals in the drug composition pass into the gastro-intestinal fluid in a molecular form. This event resembles the dissolving of a sugar cube inside a glass of hot tea. First, the sugar cube gets broken into pieces and then dissolves. A mix with a tea spoon makes this event happen a little faster. In a similar fashion gastro-intestinal movements help with the absorption of medicine. Liquid drugs like syrups dissolve in the gastro-intestinal fluid faster since they are already in smaller units; therefore they get absorbed faster.

Drugs mostly get absorbed through the small intestine. The most important task of this organ is to enable the absorption of nutrients. It is approximately 10 meters long and 4 centimeters wide. The inner lining of the small intestine has finger-like projections called villus and even smaller projections that are located on these villi are called microvillus. One of the reasons, maybe the most important reason, why the our intestines are created in this way is that as a result, the inner surface area of intestines increases multifold. Such that the inner surface area of a human beings small intestine can increase up to 200 m2 and this greatly facilitates the absorption. These projections are made of intestinal cells.

The molecules carrying the medication reach the capillary vessels by passing through these cells and then join the blood stream by crossing through capillary vessel cells. Furthermore, intestinal cell membranes host a special protein that filters unwanted substances for the cell and returns them back to intestinal lumen. Thus these unwanted substances are excreted out of the body along with other unabsorbed matter. In the same way, some drugs are held by this protein and released back into the lumen thus decreasing absorption rate for drugs experiencing this reaction.

Liver: The organ responsible for eliminating the harmful effects of medication

As soon as medication joins the bloodstream after absorption, it is first transported to the liver. This is because pulmonary veins that collect blood from the intestines are connected primarily to the liver. One of the many functions of the liver is the elimination of harmful substances entering the body. For this reason, absorbed substances are directly sent to the liver. The liver is employed with the task of chemical conversion with these substances that are transported to it. One of the wisdoms behind liver metabolism is to reduce the effects of these harmful substances via these events and to convert them into an excretal material. In the same way, drugs are metabolized in the liver, lose their efficacy and prepare for excretion.

Many drugs interfere with each other’s metabolism. If one drug’s metabolism is inhibited, blood concentration of such chemicals increase and adverse effects of drugs become more frequent. Irresponsible drug use must be avoided for this reason. Drug interactions may lead to major damage in addition to the drug’s individual adverse effects. Moreover different nutrients also affect drug metabolism. For instance, grapefruit inhibits metabolism of certain medicines, as a result blood concentration of these medicines increase and adverse effects can be observed. On the other hand, some nutrients like broccoli, cabbage, and charcoal roasted meat speed up the metabolism of certain medicines. In this case, the blood concentration of the affected drug drops and may lead to reduced benefits from intended use. Because of this reason, patients on long-term medicine treatment should not consume these types of food.

The rest of the drug molecules that escape these metabolisms is directed towards blood vessels feeding other organs. Some drug metabolisms in the liver present individual differences as metabolic levels change from person to person. Thus, a drug with the same dosage develops desired blood concentrations for some people, fails to meet this level for others or can even cause high blood concentrations enough to generate adverse effects in other individuals. That is why a medicine that has benefited a patient should never be used by somebody else without consulting a doctor.

The function of bile

Bile secretion originating from the liver and gall bladder has critical importance in the digestion and absorption of fats. Bile breaks apart fats into small pieces so that digestive enzymes can affect them. As a result of this, absorption is provided for fats and vitamins like A, D, E, K that are soluble in fats. In a similar fashion bile improves solubility and absorption of some drugs that does not dissolve in gastro-intestinal fluid. Another task of bile secretion is the removal of certain substances from the body. Waste materials in the bile that is dumped into duodenum are excreted through the digestive track. Some drugs are excreted in this way.

Drug intake before or after meals

It is a well known practice that medications are advised either to be taken after or before meals. When medications are taken after a meal, they cause less of the possible unwanted disturbances such as stomach sickness, aches or indigestion.

On the other hand, nutrients may reduce intake of certain drugs, therefore they need to be taken before meals. However medications taken right before a meal does not apply in this case since the food will still mix with the medication in the stomach. When taking these medicines, it should at least be an hour before meals. Generally consumption of a medicine before or after a meal does not really change its absorption level. But medications taken before meals pass the stomach into the intestines without delay and therefore get absorbed faster. This practice is important in cases where an immediate effect is desired such as pain relief. Plentiful water intake also helps with faster and improved absorption of drugs.

Some medications are packed into capsules made of gelatin-like substances. Medicines with undesirable taste and smell can be offered in this form for consumption. Moreover, if a drug is harmful to the stomach or gets degraded in stomach acid, then this drug can be prepared in capsules that are durable to stomach acid but soluble in the intestines. That is why consumption of medication without its intended capsule should be avoided. In a similar fashion, some medicinal tablets are designed to deliver its molecular contents particularly to the intestines. These types of medication must be taken as a whole unit. Otherwise it can be ineffective or may lead to harmful reactions.

Delivery of drugs to targeted regions

The molecules carrying medication that join the blood via absorption get dispersed by blood circulation throughout the body. These molecules reach various parts of the system via blood vessels, and then diffuse into organs via capillary vessels. However, their entry to the brain is difficult because this vital organ of the body has a special protection to guard itself from possible harmful effects of various substances that enter the body from the outside. Capillary vessels in the brain are different from other capillary structures in the rest of the body as they are created without an intercellular space in between vessel cells. Furthermore, these cells are bound to each other with their tight connective regions.

These capillaries are surrounded by a thicker membrane compared to other capillary vessels. This membrane is also host to various cells that wrap around the vessel. Therefore, because of these factors and other similar ones, some medications can enter the brain in very limited amounts. Drug molecules can display their targeted effects when they bind to target proteins, called receptors, in the organs. These proteins, which are very unique to each drug, exist on the cell membrane or in the cell. In addition, drug molecules also bind to other receptors that are not specific for them, and this causes adverse effects as a result.

Excretion of drugs from the body

Drugs are excreted from the body via the liver and kidneys. One function of these organs is to filter the blood from foreign substances. It was previously mentioned that absorbed substances from intestines are transported to the liver first where some amount gets metabolized and the remaining amount rejoins blood circulation that feeds other organs. Drug molecules that pass through the liver return back to it repeatedly many times because of continual blood circulation. In each of these arrivals, some amount is again metabolized. Molecules of metabolized drugs are excreted out of the body via the kidneys and through the bile at a limited level.

Only some portion of drug molecules get excreted via the kidneys without being metabolized. This ratio is higher with some medications. These types of medications are considered to be removed only by the kidneys, whereas some other drug types cannot be excreted without getting metabolized through the liver. As previously mentioned, the purpose of drug metabolism is to convert drugs into easily removable forms. If these types of drugs are not metabolized, they are rejoined to the blood circulation after filtration by the kidneys without joining the urine. It is impossible for the liver to sense these happening within the kidneys if it was not that the liver and every cell in it were employed by one authority who created them in the first place. Drug molecules concentrate in the liver and kidneys since these organs are employed with drug removal. As a result harmful effects of drugs are often experienced in these organs. Therefore unnecessary drug use should be avoided, otherwise the health of these organs deteriorate and eventually fail to carry out their basic functions.

As noted above, events that are taking place within many of our organs, stomach and elsewhere like kidneys impact on the journey of drugs in our body, therefore changing its effect. The harmonious creation of our organs that are home to many miraculous events is the major component of the entire process in which causations have their due role only as much as they are allowed by their Creator. As a test for humankind, both illness and the cure is provided by God, the All-Healer. Therefore it is the duty of a patient to see a doctor, take the medication properly and never forget that cure is only provided by the Almighty, without obsessing over causational chains.

References

• Guyton, Arthur C., John E. Hall. 1991. Textbook of Medical Physiology, Saunders.
• Patton, Kevin T., Gary A. Thibodeau. 1993. Anatomy & Physiology, Mosby.
• Rang, Humphrey P., Maureen B. Dale, James M. Ritter. 1999. Pharmacology, Churchill Livingstone.
• Brunton, Laurence, John Lazo, Keith Parker. 2006. The Pharmacological Basis of Therapeutics. McGraw-Hill Professional

In this issue we examine diverse topics from astronomy to art, from dialogue to genetics. On reading the lead article, you will be filled with hope that once those “who are spiritually alert with faith, hope, and tenacity” roll up their sleeves ready for work, the true message of Islam will be revealed to everyone in the world, for Islam is “a combination of systems that is perfectly compatible with human nature and rich enough to meet all the material and spiritual needs of humanity.”

Although we see it every day as the source of light and heat above us, most of us do not know that the sun is like an “enormous piano with ten million notes.” “The Trembling Sun” expounds on how helioseismologists gather important information about the sun’s core by studying the echoes that appear on the sun’s surface from the energy produced by these ten million notes.

From the macrocosmic sounds of the sun we move on to studying the marvelous microcosmic world of seeds in “Tiny, With A Great Mission,” which is a contemplative piece on how seeds are equipped with all the necessary information, how are they programmed to become the plant they are meant to be, and so on. In “Will and Balance in Nourishment,” we learn that there is no limit to the absorption of foods that have high calories (lipids, carbohydrates, and proteins), and that this can lead to being overweight. However, in the absorption of minerals, the rules of dynamic balance occur in our intestines, regardless of our will, by the help and mercy of God. The former becomes a test of our appetite, while the latter is a measure divinely installed in our body to protect us from various malfunctions. A similar protective mechanism is found in the DNA, our genetic coding. “A Miraculous Mechanism: DNA Repair” lists various precautions to prevent DNA damage, such as detection by sensor proteins, the damage checkpoint process, and apoptosis.

We are grateful to the authors for their contributions, and owe a special thanks to Ozge Ozturk, Hacer Sartepe, and Sermed Ogretim for their help in producing this issue.

With this act, the holy Pole meant, “Whenever your son’s spirit prevails over his body, and his heart over his carnal soul, and his intellect over his stomach, and he demands pleasure for the sake of thankfulness, then he can eat delicious things.” (Said Nursi, Nineteenth Gleam, 3rd point.)

I too witnessed a similar incident thirty years ago. With a large group of friends from university I was invited to visit a well-known scholar for whom I had a deep respect. We had the opportunity to attend a dinner with him and among the food served were some delicious cherries. My inner voice said, “If I sit near him, I will not be comfortable enough to eat as many of those cherries as I like.” This was exactly what happened. While I was thinking about how to get a chance to eat more of the cherries, that respected person took one of the cherries, excused himself, and left the table. I still cannot forget how ashamed I was of my thoughts at that time.

As a result of the story of Abdul-Qadir Jilani and my own experience, I started to ponder the activities that function so well in the human body. In medicine, the dynamic balance that entirely governs the body during eating, drinking and digestion is known as homeostasis. The most crucial body fluid in this balance is the blood. All the agents in the blood have a fixed quantity, a fixed measure and are supplied at a constant rate. Blood pressure is stabilized according to the characteristics of each vein. For instance, the average blood pressure of large arteries is about 100 mmHg. If the pressure exceeds this figure, then the result is hypertension. Hypertension can lead to cerebral hemorrhages, paralysis, renal failure, cardiac expansion, cardiac failure and heart attacks, all of which can result in death. As for hypotension, this is when the flow of the blood to the organs, mainly the brain, lessens. Another example of the importance of maintaining balance is that the agents which are responsible for maintaining the concentration of sugar in the blood (glycemia) must be kept at a suitable balance. If the ratio of the blood sugar (glycemia) rises, the person may go into a sugar coma, which is life threatening. However, if the ratio of blood sugar drops, the organs, in particular the brain, are deprived of energy. A hypoglycemia coma (when blood sugar is too low) is even more dangerous for the brain than hyperglycemia (when blood sugar is too high). The concentration of sodium, potassium, chlorine, calcium and fatty acids present in the blood, like sugar, are kept in a dynamic balance. If this concentration is upset, the result may be disease or even death. The Owner of Absolute Will and Infinite Mercy keeps all these in balance thanks to the marvelous mechanisms that He has placed in our bodies. However, we are free as far as actions like eating and drinking are concerned, for we are granted the willpower to choose our actions.

Balance in nourishment

One of the most often discussed medical subjects in recent years is obesity. This is an important health problem that poses a threat to life, and it is related to diabetes, hardening of the arteries (arteriosclerosis), fatty liver, cirrhosis, cardiac failure and heart failure. Apart from using one’s own will power and eating less, doctors have presented other harmless ways that are appropriate to human nature to treat obesity. Being overweight constrains the ability of a person to move (exercise) and this inactivity, in turn, leads to more and more weight gain. God has enabled us to seek nourishment wherever we like, within certain parameters. Naturally, our stomach has a certain capacity and when this capacity is met, we feel full and do not need to eat any more. Yet, even though we feel full and should not eat, as this is what is necessary for the health of our body, we are overcome by our lower self and tend to overeat extravagantly. The problem of obesity seems to be greater in developed countries.

Our Creator has not put any restrictions on the absorption of food into the blood. All the food we eat is taken into the intestines so that the nutrients can pass into the bloodstream. If the dynamic balance (homeostasis) were to be maintained here as well then the body would take as much as it needed and the surplus of food would be evacuated from the body without going into the blood; as a result, obesity would not be a concern, however much a person might eat. But by allowing all the food we eat to pass into the bloodstream, the Absolute Ruler has set a test for us, challenging our wills and warning us about self-control.

Most of the activity during digestion and absorption takes place in the small intestine. Our small intestine is a duct which consists of three parts, namely the duodenum, jejunum and ileum, each having different functions and structures. The length of the intestine is 3–4 meters, and it measures 2–4 centimeters in diameter, varying according to the position in the body. The area of the inner surface of this cylindrical structure is 1,600 cm2 (0.16m2) at its maximum. The inner perimeter of the intestine is not like a flat tube, but rather it has folds, each measuring about 8 millimeters, that stretch over the inner parts of the canal. These folds allow the absorption surface to be increased about threefold. If the inner surface of this structure were flat, the absorption capacity of the small intestine would not be more than 1/600 of its present capacity. The surface of these folds is also not flat, but covered with protrusions called villi that are shaped like a finger; these stretch into the vacuum of the canal by about 1 millimeter. There are between 20 and 40 villi to every square centimeter on the surface of the intestine. These villi allow for there to be a tenfold increase in surface absorption. The surface of the villi has cylindrical cells that are arranged in a single row and these help in absorption. The surface of these cells has extensions that are quite thin and dense, known as microvilli, or epithelial cells. Thanks to these cells with a brush border surface, the absorption surface can increase by about twenty times. Thus, although the surface area of a flat canal of the same size should be approximately 3,300 cm2, thanks to surface folds, villi and bushy edges, the total absorption surface of the small intestine increases to 2 million cm2 (200 m2). Moreover, some research has suggested that the total increase could be even greater (about 1,000 times as much). Normally, 100 grams of fat, 50–100 grams of amino acid, 50–100 grams of iodine, and 7–8 liters of water (consisting mostly of fluids produced within the body) are absorbed by the intestines daily. Furthermore, if one eats or drinks too much, the maximum capacity of the system allows the absorption of several kilograms of carbohydrates, a half to one kilogram of fat, a half to one kilogram of protein and twenty liters of water per day. Our intestines have been created with the capacity to transfer all this food into the bloodstream. If we do not control our eating, this capacity is abused and we can face conditions like obesity.

In this life, one of whose tests is in our body, and in which we are required to strive hard using our willpower, there is no limit to the absorption of foods that have high calories (lipid, carbohydrate, and protein), and this can lead to being overweight, as mentioned above. However, in the absorption of minerals, which are not normally considered as making up the basic components of nourishment, but which are of the utmost importance for the human body (in all the operations of the nerves, muscles, bones and in the balance of all the electrolytes), the rules of dynamic balance occur in our intestines, regardless of our will, by the help and mercy of God. For instance, hemoglobin, which is found in the red blood cells (giving the blood its red color) and is charged with the task of transporting oxygen, contains iron. When there is surplus iron in the body, hemosiderosis occurs, which leads to the destruction of organs such as the liver and the pancreas, or cardiac failure. If there is an iron deficiency, then a person suffers from anemia. It is for this reason that a quite sensitive iron-absorption balance exists in our intestines. Here, it is evident without question that there is Divine Aid and Mercy. The same mechanism works for substances like calcium.

Prophet Muhammad’s, peace be upon him, advice to stop eating before feeling full is a significant measure against obesity, for it eliminates “false” appetite. This has a psychological truth, for the brain responds to the feel of fullness a short time after eating. In fact, we all know by experience that we actually feel full a short while (fifteen–twenty minutes) after we stop eating even if it is a small meal.

To conclude, the Almighty One warns us against extravagance and orders us to use our willpower. At this point, we can see how important a role the blessing of religious belief and the training of the soul and the will play in eating habits. Likewise, the principles of Islam, which is in perfect keeping with human nature, are crucial for the well-being of the community as a whole; charitable alms and fasting, which urge us to help and think about those with less, are obligatory and all kinds of charity and good deeds are encouraged. In Islam extravagance is prevented, not only in eating and drinking.

Omer Arifagaoglu is a professor of medicine in Turkey.

It is worth contemplating that humans are in need of microorganisms to survive and that living things as insignificant (!) as bacteria are necessary to synthesize B12 vitamin. Why our so-called bacteria ancestors (!) from which we evolved – as some claim – lost this ability to synthesize B12 vitamin which was, and still is, vital for survival, is a challenging question for those scientists who support the theory of evolution.

The journey of B₁₂ in our body

Cobalamin, which is taken in with food, is absorbed by the final section (ileum) of the small intestine and transported into the blood by receptors on the cell membrane. For B12 to be absorbed into the blood, it is necessary to have an “intrinsic factor” bound to this vitamin. The intrinsic factor is a glycoprotein produced in parietal cells that secrete gastric acid. After the absorption, the vitamin binds to transcobalamin, a carrier protein found in the blood, and it is then being bound with transcobalamin II so that it can penetrate the cells. B12 can be stored in the liver to meet the needs of our body for a long time. A deficiency in cobalamin due to a poor diet (e.g., vegetarians) or a failure to produce the intrinsic factor in the stomach may result in pernicious anemia, which is fatal. Cobalamin deficiency negatively affects DNA synthesis, which is necessary for production of new cells, particularly in the division of the stem cells that are assigned to construct new red blood cells. This is followed by the circulation of cells that will generate underdeveloped red blood cells; these cells will not be able to function properly and will have larger diameters.

The training of parietal cells

If the stomach is removed or cannot produce the intrinsic factor, it is impossible for B12 to be absorbed. It is worth reflecting on the wisdom of why an organ like the stomach, the main duty of which is to partially digest food and convey it to the intestines, synthesizes intrinsic factor. How can the stomach know that our body is in need of this protein? How did it become able to synthesize this very special composition of glucose and protein which is so necessary to absorb intrinsic factor through the gastrointestinal tract? Why doesn’t our body produce the vitamin in the first place, instead of binding it to such a complex molecule? And how do the parietal cells know what is necessary to bind this vitamin, the use of which they cannot understand, although they have never been trained in bio-chemistry, physiology, or pharmacology? In which laboratory did these cells synthesize and test this compound?

The intrinsic factor

In order to decompose proteins into amino acids, the stomach secretes hydrochloric acid and an enzyme called pepsinogen. Parietal cells that secrete acid also produce a protein (intrinsic factor) which is not damaged by the acid or the pepsinogen enzyme. How were these cells able to develop a synthesis in which proteins do not decompose, which can protect them from the acid in the stomach, and bind themselves to a vitamin like B12, which is absorbed only in very small quantities?

The hydrochloric acid secreted in the stomach is like bleach and it irritates anywhere that it goes other than the stomach. Should even the slightest quantity of this acid pass into esophagus (reflux, diaphragm boiling) it can cause severe burning. It is amazing that B12 is found and bound in a cauldron like the stomach, but is not damaged by the acid produced when the stomach is filled with food and drink.

The intrinsic factor bound with the vitamin goes on its journey and it reaches the absorption region in the last section of the small intestines. During absorption, the gates on the cell membrane of the intestines open up only to allow the B12 intrinsic factor compound. Maintained in the intestinal cell for a while, the B12 vitamin binds to the transporter transcobalamin and is conveyed to the cells through the blood. After reaching a cell, the vitamin, needed by the entire body, is bound to another transporter: transcobalamin II.

Some components, although they appear to be very simple, must be supplied from outside our bodies if we are to survive. B12 vitamin is one such component, and it certainly deserves to be studied well.

The human eye can identify colors within a 360-760 mm distance. The limits of a curved sight cover the yellow-green field. Every leaf and blade of grass reflects light in this field (540-560 mm), and the human eye can detect thus detect green more clearly than any other color. In other words, God, the All-Knowing, made our eyes see the peaceful and lively color green more easily than other colors, and He granted us the ability to distinct over fifty hues of green – more hues than any other color.

In addition to green, the human eye also perceives the color red, the color of of begonia and barberries, which are colored with antocyan. But there is a chlorophyll layer with its distinctive green under the red layer on top of the leaves. Only a human can see a begonia like this – for example, a bee sees it in black.

Biologists found out that greenblue seaweed, which is really spread all over the world, used to provide our planet with oxygen billions of years ago, contains not only “A”- type chlorophyll, but also other pigments. The human eye, however, is “determined” to see only the green seaweed component created in order to saturate the environment with vital oxygen.

Claiming that “mother nature” has executed such a complicated selection, for the sake of Charles Darwin’s principles, is impossible – it would be more realistic to expect a typewriter to write the encyclopedia Britannica by chance.

We must, however, concede a very important detail. Energy absorption of phototrophic organisms, which is dependant the Sun, is adaptively connected with continuously changing levels of solar radiation. As it is known, the latter comes into soil, which then nourishes plants by facilitating the absorption of energy in a selectively narrow diapason (400-900 to 400- 700 nm). It is impossible to modulate an optimal situation for a plant to be nourished through evolution. A blind evolution would not achieve that in a time span much more time than the multibillion age of our Universe. This leads to the conclusion that the Creator made the specific system of energy absorption in plants via rays projected to the Earth by the Sun.

Aside from the fact that green is created and chosen by God, one more detail deserves listing. Objectively a plant’s leaf and its pigment are connected with selective spectral energy absorption. Emanation with different quanta outside of this precise and narrow “adjustment” could have any influence – negative or positive. Pigment of another kind would not function to fulfill its purpose to be vivifying. Is not turning the ruthless solar radiation into a life-giving flow a manifestation of His wisdom and of the love He has for His creations?

In our everyday life, we engage in amateur garden work or we just admire trees and bushes in bloom. This wonderful event, this miracle, appears to us as something routine. Pigments are highly organized; they are “adjusted” to radiation, which means that their spectrums permit them to absorb radiation in the diapasons at their limit intensity. Moreover, a plant’s organism is always able to increase/decrease this intensity.

For sure, there is one more obvious thing – the issue of the maximum solar radiation is relative. The problem is that according to every scale of wave length, maximum radiation is registered at 578 nm., and at 1015 nm. It would be even more, 1804 nm, if read according to the quantum quantity scale.

From the point of view of basic quantum physics, the most prominent authority on understanding of the role of God in the act of creation, the green color of a leaf is understood to be connected with the features of the pigment itself, the most suitable for the function of absorption and transformation of ray energy.

Another issue is also very important – what determines the diapason of a ray’s energy is its FAR and its photosynthesis diapason accordingly. If we do not accept God as Creator, it is hard to imagine how nature, through all its stages of development led the only source of inner energy, the ATF molecule – through anaerobic, then aerobic breathing and ultimately to all the forms of photosynthesis. This molecule with the energy of its chemical compound in the living system of some 10 Kcal/mole remained in the green plant, but it was not only the breath that was the source of its creation.

I would like to share my observations of over fifty years. As the solar ray energy has become the most important source of energy for plants, simplifying a number of arguments, I can say that the plants are granted a mechanism able to form universal inner quanta divisible to ATF in energy as well as to a photosynthetically important compound named NADP.H (50 kcal/mole each). This is based on the features and spectrum of chlorophyll. The quanta are one of the strongest donors of “his majesty the electron!” Please tell me who will speak of blind evolution after considering these “coincidences”…

I would like to share my observations of over fifty years. As the solar ray energy has become the most important source of energy for plants, simplifying a number of arguments, I can say that the plants are granted a mechanism able to form universal inner quanta divisible to ATF in energy as well as to a photosynthetically important compound named NADP.H (50 kcal/mole each). This is based on the features and spectrum of chlorophyll. The quanta are one of the strongest donors of “his majesty the electron!” Please tell me who will speak of blind evolution after considering these “coincidences”…

“Let all the breathing praise the Lord!”

There is a simple conclusion that could be made from all the above. If such “portions,” or quanta, are formed from solar energy absorbed by plants, then means the primary products of the same type can be also formed. “The quality of light” is of no metabolic importance for the process of synthesis in the limits of ray energy. The Word of God, once spoken out, is realized in a determined way, far distant from Darwinian theory.

Long years of experiments, research, and consultations with colleagues from around the world persuaded this author to change his opinion from vulgar materialism to a deeper understanding. Properties in plants are not the result of “calculabilitive” photosynthesis “touched” by science; like all things, these properties are of a manifestation of His, just as are the lives of humans.

This is the irrational choice of my soul. Nonetheless, as it was admitted in the works on the general problems of science and historic knowledge by the Chief of Department of Civilization Problems at the Russian Academy of Natural Sciences by Prof. V.I. Sheremet -the real breakthrough can be reached with faith in God and exploring the undiscovered. So I offer a second conclusion devoid of materialist explanation. The pigment apparatus of a plant is a complicated chlorophyll-protein complex that functions jointly with its intended object. Who determined this program of compatibility? The plant – the main hero of this article – is given the ability to form a physiological quantum of 50 kcal by itself. Moreover, a high intensity green quantum from outside cannot be used by a separate chlorophyll- protein compound.

The conclusion is obvious and simple: a plant’s life cycle is realized only according to His will and in the regime determined by Him. “Monochromatic” sources of ray energy are not suitable, nor welcomed, by God for the full-fledged artificial raising of plants, but it can be of use for the photosynthesis regulation. So, hotbeds are useful and necessary. The generalized summary is as follows. The green color of leaves and, the blue of the cloudless sky, are not random, they are the work of intelligent design.

So let the green color – the color of plants, of nephrite, malachite, and beryl – beloved and honored both in the East and in the West. Let the mysterious “green ray” of a seaside sunset, let the green stripe of the rainbow, the bridge to Heaven for the righteous, remain the symbol of His Will, His Life, His Awakening of spring in the peace of the heart.

May peace be with all of you, dear readers! 

We all know that it is essential for life. However, probably because of its abundance and simple chemical composition, we often regard this tasteless and odorless substance as being important, but quite simple and ordinary. Scientifically, it is the exact opposite. It appears to show extremely complex and unusual behavior. It is the most studied substance on Earth. Yet, scientists are still puzzled over its strange properties. Even the best computers we have today cannot simulate all of the different properties of water.

Let us look at an example of the surprising properties of water. The strangeness of water starts with the fact that it exists on Earth. Water, being composed of two fairly light atoms (hydrogen and oxygen), should be in the gas phase at the usual temperature ranges that exist in our world. In fact, all compounds that are close to it (i.e. H2S, H2Se, and H2Te) are found mostly in the gas phase. But, compared to similar substances, it melts about 100 degrees above the expected melting point and it boils about 150 degrees above the expected boiling point (see Figure 1). The result is that it is the only material that exists naturally in all three forms (i.e. as ice, liquid, and vapor) on Earth.

In addition to the example given in the previous paragraph, water has at least 40 different surprising properties (See for example the “Forty-one anomalies of water” section in Ref 1). But, what is even more astonishing is the fact that most of these anomalous properties of water are absolutely crucial for life. Simply stated, life on Earth depends on these extraordinary aspects of water. Below we will discuss some of the anomalous properties of water and their importance for life. At the end we will briefly try to explain why water behaves so differently.

1-Water Has an Unusually High Heat Capacity

Heat capacity is a measure of the ability to store heat. Formally, it is defined as the amount of heat required to raise the unit mass of a substance by one degree of temperature. If the heat capacity of a substance is high, it will store heat well, i.e. its temperature will not rise much for a given amount of heat. Water has the highest heat capacity among common substances. This has a crucial impact on our life.

It is thanks to this fact that living organisms, which are mostly composed of water, can regulate their body temperature easily. For example, the human body needs to keep its temperature between 36.1 and 37.8 °C. This is only possible because it is composed mostly of water. Since the heat capacity of water is unusually high, even if the temperature of the environment changes greatly, the heat exchange between the body and the environment does not cause a great change in body temperature.

Another consequence is the moderation of the climate near large masses of water. The heat capacity of land is much less than that of water. This is why the temperatures of oceans tend to vary much less than that of land. The temperatures in the oceans vary between -2 0C and 35 0C. On land, temperatures may vary anywhere from -70 0C to 57 0C. Compare also the Moon, which has no water. Temperatures on the Moon range from -155 0C to 135 0C.

In addition to having a great heat capacity, water conducts heat more easily than any other liquid, except mercury. This makes the temperature quite uniform in living organisms. Also, the vertical temperature profile in oceans and lakes is essentially uniform due to this fact.

2- Water Has an Unusually High Heat of Evaporation

When a liquid evaporates, it absorbs heat from the environment. This energy is used to transform molecules into gas form. The heat of evaporation is defined as the amount of heat required to convert a unit mass of liquid into gas. Water has an unusually high heat of evaporation compared to most other common substances. It is so great that you need to supply about five times the amount of energy to evaporate water that is needed to heat it from 0 to 100 0C.

This fact is crucial for the evaporative cooling system of the human body and animals. When we sweat, the sweat absorbs heat from the body in order to evaporate. Since water has a very high heat of evaporation, effectively a large amount of heat is removed from the body through sweating. That is why when we engage in physical activity we sweat. Excess heat in the muscles is easily removed through the evaporation of sweat thanks to the high heat of the evaporation of water.

The high heat of evaporation also prevents dehydration. If it were low, water would then evaporate easily from the body and we would quickly dehydrate.

3- The Density of Water Behaves Unusually as a Function of Temperature

The density of almost all other liquids decreases with increasing temperature. Water is an exception to this. Starting from 0 °C, the density of water increases, and reaches a maximum at 4 °C, decreasing afterwards. Also most other liquids become denser when they condense, but water is an exception to this as well. The density of ice is less than the density of water, which is why ice can float on water.

Both of these exceptions turn out to be extremely important for underwater life. When the weather gets cold near a lake, first the temperature of the lake’s surface starts to decrease. As the temperature of the surface cools to around 4°C, it becomes denser and can move downwards, letting the warmer water reach the surface. Therefore, before the lake can start freezing almost all of the water in it needs to be cooled to approximately 0 °C. If there was not an anomaly at 4 °C then water would begin to freeze from the surface before the entire lake cools to 0 °C. Since water has an enormous heat capacity, the necessity for the entire lake to cool to approximately 0 °C before any freezing can occur delays the freezing considerably. It is also crucial that the density maximum in water is near freezing point, not at any other point.

When the temperature finally gets to 0 °C and the water start to freeze, it will start to freeze on the surface. Since ice is less dense than water, it will float on the surface and will not sink to the bottom. And once a surface layer of ice is formed, it will protect the rest of the lake from the environment and no further freezing will occur. There would not be any underwater life if ice formed on the bottom. It would also take forever for the ice to melt if it was formed on the bottom rather than on the surface.

The fact that water expands upon freezing is also important for the formation of soils. When the water freezes inside a rock, it can easily crack it into pieces, just like a soda placed in the freezer explodes upon freezing. Therefore, one of the most important steps of soil formation is dependent on this exceptional characteristic of water.

4- The Absorption Coefficient Anomaly in the Visible Region

Another interesting property of water lies in its absorption of light. Every

substance has a characteristic absorption spectrum that shows how much light at a particular wavelength is absorbed. If the absorption coefficient is high at a particular wavelength then the material will look opaque at that wavelength. If it is low, light at that particular wavelength will be transmitted and the material will appear transparent.

In Figure 2, the absorption coefficient of water is plotted as a function of wavelength (red line). The first thing you notice is that water has a very high absorption coefficient, except for a very narrow region around 500nm. In this small region of wavelength, the absorption coefficient is ten million times smaller than the neighboring regions. What is more interesting than this enormous drop in the absorption coefficient is that this dip happens exactly at the visible part of the spectrum. The human eye can only see wavelengths between 400-700 nm. This visible part of the spectrum is indicated by a rainbow colored strip in the graph. It is amazing that this exactly coincides with the region where water is transparent. Adding to this pleasant surprise is the fact that the amount of light emitted by the sun peaks around this dip as well.

Everything is conveniently adjusted for the habitants of this blue planet. The maximum intensity of emitted sunlight happens to be in the narrow range of the spectrum that we can see. And water on the atmosphere lets this part of the spectrum through thanks to the strange dip in the water absorption spectrum. Worried about the dangerous UV radiation from the sun? This is taken care of too. Just below the visible region, the absorption coefficient of water is ten million times higher. So water vapor in the atmosphere very effectively removes most of the dangerous UV light and shields us.

The spectrum of the light from the sun, the absorption spectra of water and the visible region of the spectrum that we can see are all physically independent phenomena. Yet, it is worth noting that each of these phenomena behaves in such a way that it seems they should have a precise knowledge of each other. If you think this is too much of a coincidence, there is even more. Water is also designed to maximize our visual pleasure. You are probably astonished by the lovely color match between the blue sky and the blue sea. Most people assume that this is because the sky is blue and the sea appears to be blue because it reflects the sky. In fact this is wrong. Water is blue since its absorption coefficient is higher in red; therefore it absorbs more red and reflects the blue part of the spectrum. This can be seen in Figure 2, in which the absorption coefficient in the red colored segment of the rainbow strip is more than 100 times greater than the blue part. The sky is blue for an entirely different reason (since it is blue light that is scattered the most by the nitrogen in the atmosphere). Again two very different, independent physical phenomena are at work here, but the result is a pleasant view for us.

Why is Water so Strange?

Most of these unusual properties of water are the result of the collective behavior of water molecules. That means that one cannot understand them just by thinking about a single H2O molecule. A single H2O molecule is a polar molecule: the two H atoms are slightly positive and the O atom is slightly negative. So when you put these molecules close to each other, the positively charged H atoms are attracted to the negatively charged O atoms of the neighboring water molecules. This is called “hydrogen bonding.” Because of this, molecules tend to order themselves rather than moving randomly, even in liquid water.

Hydrogen bonding is thought to be responsible for most of water’s strange properties. This is why, for example, water has a high boiling point and a high heat of evaporation. Extra energy needs to be supplied to break the hydrogen bonds before boiling and evaporation can occur. Another example is the high heat capacity. As water absorbs heat, it stores this as potential energy by breaking hydrogen bonds without considerably increasing its kinetic energy. This leads to a small temperature increase, therefore a high heat capacity is created for a given amount of heat.

But not all of the anomalous properties of water are that simple. Some of them are not even understood today, despite a considerable amount of current research. For example, water seems to play a crucial role in protein folding. Protein folding is the process by which each protein acquires a unique three-dimensional shape. And it can only function effectively in this particular shape. Despite millions of different possible folding configurations, a certain protein will always fold into its unique structure within milliseconds. But how can a protein always find its way to the same configuration? Water comes into play at this point. It is thought that the hydrophobic (water repelling) interactions between water and protein molecules and the hydrogen bonding interactions in water are major driving forces in protein folding. The exact details of this are still not known. Understanding them is the key for understanding many diseases and developing drugs.

In summary, water is central to our lives. It accounts for a large proportion of our bodies, we drink it, fish in it, and wash and swim in it. But we usually are unaware of how remarkable it is. Here, we have given only couple of examples of the anomalous properties of water that are also crucial for life. Scientifically, our understanding of water is far from being complete. It seems, as the research continues, that the already long list of mysterious aspects of this miraculous substance will get even longer as we learn more about it. On the philosophical side, it is interesting to note that a very simple molecule (H2O) has been selected as a means to do all of these vital, complicated, and unrelated jobs, all at the same time through its unexpected and surprising properties. 

References 

• “Water Structure and Behavior,” Martin Chaplin, www.martin.chaplin.btinternet.co.uk
• Segelstein, D., 1981: “The Complex Refractive Index of Water”, M.S. Thesis, University of Missouri-Kansas City.
• www.biology.arizona.edu/biochemistry/tutorials/chemi stry/page3.html
• www.hyperphysics.phy-astr.gsu.edu/hbase/chemical/water.html
• “Water – The Marvellous Molecule”, BBC TV program.
• www.bbc.co.uk/worldservice/programmes/archive/030430_molecule.shtml