“Free radicals” are a special type of atom that have been linked to many age-related diseases. They form as a result of a process called Oxidative Stress, which takes place when an oxygen molecule splits into single atoms with unpaired electrons. The nature of electrons is such that they like to be in pairs and as a result will “freely” and “radically” search throughout the body for another electron to pair with. They could almost be considered romantic if they were not so dangerous!

Their main danger comes from the damage that they cause to cells or cell membrane, proteins, and DNA. Cellular damage occurs when free radicals travel through cells and disrupt the structures of other molecules. The gradual accumulation of them, and the increased damage that builds as more and more of them collect, is what helps cause many of the aforementioned aging diseases. Our body is under constant assault from oxidative stress, and cells may function poorly or die if it occurs too frequently and without proper bodily maintenance.

Free radicals are a waste byproduct that form as a result of various chemical reactions that take place during our bodies’ normal metabolic processes. They are then “dumped,” and their eventual buildup will often harm our bodies much like how factory waste harms the environment However, they are not entirely useless; it is impossible for our bodies to turn air and food into chemical energy without a chain reaction of free radicals. Free radicals are also a critical part of the immune system, as they additionally move through our veins and can confront foreign invaders [1].

What are free radicals?

Understanding free radicals necessitates an elementary knowledge of chemistry.

Electrons orbit around atoms in levels called shells. Each shell is filled by a fixed number of electrons, and when the first shell is full then electrons will start to fill the next shell.

If there is an atom whose outer shell is not full then it may bond with another atom by using the electrons to fill its outer shell. These types of atoms are known as free radicals.

Atoms that have a full outer shell become stable, however free radicals are unstable. They are “desperate” to acquire the full number of electrons that are necessary to fill all of their shells and will therefore react quickly with other substances.

Take the example of oxygen molecules. If they split into single atoms that have unpaired electrons then they too will become unstable free radicals that seek other atoms or molecules to bond to. If this procedure continually occurs, then it will begin a process called oxidative stress.

Smoking, UV rays, air pollution, fast food, pesticides, ionizing radiation, drugs, and inflammation have all been linked to the formation of free radicals. We must be diligent when it comes to understanding how these influences can affect our bodily health, and then fight back with natural antioxidants.

Free radicals are heavily linked to aging

One of the effects of oxidative stress is that it can damage our body’s cells and thus promote many of the diseases and symptoms related to aging, such as wrinkles and gray hair. They will take electrons from other atoms in order to become more stable, a process that may cause diseases or signs of aging [2].              

In 1956, the “Free Radical Theory of Aging” was outlined as a way to understand how exactly our bodies age over time. Everybody ages, and as we age our body loses its ability to fight the effects of free radicals. Over time our bodies produce more free radicals and more oxidative stress, which increases the rate at which cells are damaged and thus can bring about degenerative processes.

Many age-related diseases such as muscular degeneration, certain cancers, atherosclerosis, cardiovascular disease, emphysema, Alzheimer’s disease, Parkinson’s disease, ulcers and all inflammatory diseases such as arthritis and lupus, and many others are linked to free radicals. Free radicals can be found in the food we eat such as fried foods, the medicines we take, the air we breathe, and the water we drink. Free radicals are also found in alcohol, tobacco smoke, pesticides, and air pollutants.

Several studies and theories have been linked to oxidative stress and the buildup of free radicals including: [3]

• Genetic degenerative diseases, such as Huntington’s disease or Parkinson’s
• Age-related changes in appearance, such as loss of skin elasticity, wrinkles, graying hair, hair loss, and changes in hair texture
• Cataracts and age-related vision decline
• Diabetes
• Cancer, which is associated with chromosomal effects and oncogene activation due to the reaction of free radicals [2]
• Central nervous system diseases, such as Alzheimer’s and various forms of dementia
• Cardiovascular diseases due to clogged arteries
• Autoimmune and inflammatory disorders, such as rheumatoid arthritis and cancer

The free radical theory of aging is comparatively new; however, several studies boost its credibility. Researchers focused on cell’s mitochondria, the “powerhouse” that process nutrients to power the entire cell. Experiments on rats, for example, showed a noteworthy increase in free radicals as the rats aged. These alterations coincided with age-related declines in their health. These experiments also showed that free radicals produced in the mitochondria harm the substances that the cells need in order to work properly. This damage causes mutations that produce more free radicals, thus accelerating the process of damage to the cell. This helps explain aging since aging quickens over time. The gradual, but increasingly rapid buildup of free radicals, offers one explanation for why even healthy bodies age and depreciate over time [2].

Antioxidants can stave off free radicals

Antioxidants, molecules that prevent other molecules from oxidizing and thus undergoing oxidative stress, can help to avert the harmful effects of free radicals. They can also decrease or even nullify the effects of free radicals, as they can provide an electron to free radicals and thereby reduce their reactivity. The uniqueness of antioxidants is that they can donate an electron without becoming reactive free radicals themselves.

There is no single antioxidant that can combat the effects of every free radical. Free radicals have different effects in different areas of the body, and every antioxidant performs differently due to its chemical properties. Antioxidants such as vitamins C and E, beta-carotene, glutathione, and plant estrogens called phytoestrogens all scavenge the body and help remove free radicals. Honey can also function similar to antioxidants by removing free radicals. Additionally, selenium, a trace metal that is required for proper function of one of the body’s antioxidant enzyme systems, is sometimes included in this category. The body cannot manufacture these micronutrients so they must be supplied in the diet.

Foods that are rich in antioxidants include citrus fruits such as oranges and limes, berries, and many other fruits that are rich in vitamin C. Carrots are known for their high beta-carotene content, while the soy in soybeans, and some meat substitutes, are high in phytoestrogens. Apricots, spinach, mangoes, pumpkins, broccoli, and eggplants are all also helpful, along with a plethora of other fruits and vegetables [4].

More research needed

A 2010 study on antioxidant supplementation for the prevention of prostate cancer found no benefits. Furthermore, a 2012 study found that antioxidants did not lower the risk of lung cancer. On the other hand, the study found that people who were already at a heightened risk of cancer, such as smokers, actually had a slightly elevated risk of cancer due to antioxidants.

Some investigators have found that supplementation with antioxidants is injurious when people take more than the recommended daily allowance (RDA). A recent analysis found that high doses of beta-carotene, or vitamin E, appreciably increased the risk of dying. One study found that long-term use of beta-carotene could reasonably reduce the risk of age-related mental problems [4]. But perhaps one of the most important discoveries is that antioxidants are unable to “cure” the effects of free radicals completely [5].  

Additionally, we do not yet fully understand why free radicals form in the first place. They may result as an early sign of cells fighting diseases, or that free radical formation is simply a natural expectation that comes with aging. It is not possible to understand them completely without more conclusive research, which should be encouraged considering the significant impacts that free radicals can have upon our bodies.

References

1. https://www.rice.edu/~jenky/sports/antiox.html
2. https://www.medicalnewstoday.com/articles/318652#How-do-free-radicals-damage-the-body
3. http://www.mytruehealth.info/mytruehealth_antioxidants_freeradicals.html
4. https://www.medicalnewstoday.com/articles/318652#Antioxidants-and-free-radicals
5. https://www.medicalnewstoday.com/articles/318652#What-we-do-not-know

It is a natural feeling for many people to want to turn to a higher power when life becomes almost too difficult to bear. “Irritated by Trivialities” is a poem that explores this feeling with a specific focus on the poet’s frustration with people that cause discord and violence in society. He calls upon God to grant him guidance and peace, and to break the monopoly on power that some tyrants in this world have over the innocent.

Mainstream psychology has long been a secular discipline that has shunned most efforts to include elements of spirituality or faith. However, the emerging field of Islamic Psychology looks to combine traditional, Sufi concepts of spiritual health with modern, empirical research on successful psychiatric practices. The result is the formation of the TIIP (Traditional Islamically Integrated Psychotherapy), a manual for clinicians that wish to educate themselves about this holistic approach to mental health.

The complexity of the human body is always amazing to reflect upon, and aging has consistently remained one of the most elusive areas to understand. Recent research has been shedding light upon “Free Radicals,” unstable molecules that buildup in our bodies over time and have been linked to a variety of age-related disorders such as Alzheimer’s Disease and diabetes. It is possible to remove many of these Free Radicals by consistently eating fruits and honey that contain powerful antioxidants, however it is not possible to stave them off entirely or to prevent aging. Still, the healing properties of many fruits are indeed blessings sent to us.

Lastly, we can observe immense complexity and depth within the animal kingdom. Our article “How Do Ants Know Trigonometry?” explores the Black Desert Ant and its exceptional process for finding its way home after successfully scavenging for food. Is it truly possible for such a tiny creature to develop systems so immensely complicated on its own just because it felt like it needed them?

Alzheimer’s disease is “an irreversible, progressive brain disease that slowly destroys memory and thinking skills, eventually even the ability to carry out the simplest tasks” according to the Alzheimer’s Association. Alzheimer’s affects mostly senior citizens, and symptoms first appear in most people between 60 and 70. The first signs of Alzheimer’s, though, can be noticed between the ages of 30 and 65. However, it is very rare for younger people to exhibit symptoms. Most cases of dementia are caused by Alzheimer’s disease [1]. It is known that all Alzheimer’s patients have dementia; however, one cannot say that all dementia patients have Alzheimer’s disease. Alzheimer’s is a deadly disease, finishing predictably in death [2].

Alzheimer’s disease is named after Dr. Alois Alzheimer. In the early twentieth century (1906), Dr. Alzheimer observed alterations in the brain tissue of a woman who had expired of an uncommon mental disease. Her signs involved loss of memory, language difficulties, and erratic conduct. After her death, Dr. Alzheimer inspected her brain and discovered many uncharacteristic clusters (now called amyloid plaques) and scrambled packets of filaments (now called neurofibrillary, or tau, tangles) [1].

Based on his findings, he correctly theorized that these anomalous buildups were accountable for the patient’s loss of memory and other mental complications.

The plaques and tangles in the brain are some of the foremost characteristics of Alzheimer’s disease. Another characteristic is the damage of contacts between nerve cells (neurons) in the brain. Neurons conduct communications between different segments of the brain – for example, they conduct communications from the brain to muscles and organs in the body. Many other multifaceted brain alterations are thought to play a function in Alzheimer’s disease.

In the beginning, this impairment seems to take place in the hippocampus of the brain. The hippocampus is the part of the brain that is indispensable in forming memories. When neurons perish, further parts of the brain are distressed. In the last stage of Alzheimer’s, destruction is extensive, and brain tissue has shortened substantially.

How many Americans have Alzheimer’s disease?

It is estimated   that more than 5 million Americans may have Alzheimer’s disease. If existing population developments continue, the number of people with AD will increase significantly. However, this trend can be stopped if the disease can be effectively treated or prevented.

The reasons people develop Alzheimer’s are still not fully understood. One known reason is aging.   Age is the most significant accepted risk factor for Alzheimer’s disease. In 2010, in the United States, close to 5 million people 65 years and older were living with Alzheimer’s illness. A 2013 report from the Alzheimer’s Association suggests that 1/10^th of all Americans over 65 are suffering from Alzheimer’s. The proportion goes up to about a third of the population for those who are over 85. According to the Alzheimer’s Association, AD incidence is between 60% and 80% of all incidents of dementia [3].

Incidence of Alzheimer’s disease in South Asia

Globally, at least 44 million individuals live with dementia, making the disease a worldwide health catastrophe that must be tackled. In excess of 4 million individuals have some appearance of dementia in India [4].

In the Southern Indian state of Kerala, 1066 qualified members who were cognitively regular at reference, 104 of them acquired dementia (98 of them were found to have AD) over a continuation time of 8.1 years. The occurrence rates per 1000 person-years for AD was 11.67 for persons aged ≥55 years and greater for those aged ≥65 years (15.54). Individuals who were aged ≥65 years, the global age consistent occurrence rate, was 9.19 per 1000 person-years, prevalence rate of AD raised substantially and proportionally with growing age. These are the initial AD occurrence rates to be conveyed from southern India. When compared to reports from rural North India these occurrence rates appear to be much greater. But they are comparable with those reported from China, and slightly lesser than that reported from the western world [5].

Signs of Alzheimer’s disease

Memory difficulties are characteristically one of the first signs of Alzheimer’s; nonetheless, early indications may differ from individual to individual. A decrease in other facets of thinking, for example forgetting words, sight/three-dimensional problems, and diminished thinking or decision making, may additionally indicate the precise initial periods of Alzheimer’s disease. Mild cognitive impairment (MCI) is a disorder that can be an initial mark of Alzheimer’s. However, not everyone with MCI will develop Alzheimer’s.

Patients with Alzheimer’s have difficulty performing routine things like paying bills, driving a car, or cooking food. They repeatedly ask the same questions, go astray without difficulty, misplace things or put them in unusual places, and find even easy things puzzling. As the disease advances, some patients become anxious, wrathful, or furious.

Longevity of a person with Alzheimer’s disease?

At the time of diagnosis, if the person is older than 80, they are only likely to live another three or four years. If the person is younger then 80, they could live for as many as ten years or more.

Currently Alzheimer’s disease is graded as the sixth greatest cause of death in the United States. But fresh evaluations show that the illness may be listed as third, after heart disease and cancer, as a source of death for elderly people.

At the present time, there is no cure for Alzheimer’s. However, treatment can help patients cope with symptoms [1].

In the 21^st century, Alzheimer’s can only be diagnosed with 100 percent precision through a postmortem examination that discloses the occurrence of the distinctive plaques and tangles. However, a complete examination and suitable checkup can afford a dependable diagnosis with better than 90 percent certainty.

Malformed accumulations of particular proteins inside the brain interrupt normal brain performance and produce the reasoning and efficient difficulties characteristically connected with Alzheimer’s Disease. Ultimately, as the sediments expand all over the brain, brain material begins to die. This results in additional intellectual damage. CT scans and MRI scans show the subsequent brain contraction. CT scan shows enlargement of the ventricles in the brain and loss of brain tissue in a patient with Alzheimer’s disease. Recent research is endeavoring to ascertain what produces these accumulations and is watching for techniques to avoid or change them before they cause lasting brain destruction [2].

Alzheimer’s is not curable.
Alzheimer’s is not contagious.
Alzheimer’s is not a natural part of the aging process.
Alzheimer’s is not something you get from using deodorant or cooking in aluminum pans.
Alzheimer’s is not inevitable if you live long enough.

In some families, Alzheimer’s disease is hereditary. But these appearances are very rare, and they account for fewer than five percent of all incidents. If a family member like a mother or a brother has Alzheimer’s disease, it doesn’t inevitably mean that you’re prone to contract it as well.

There is no test that can foretell whether you’ll get Alzheimer’s disease, save tests for the very rare hereditary Alzheimer’s. A blood test can tell whether you have a certain form of cholesterol-carrying protein connected with an elevated occurrence of the disease. This examination can’t convey whether you’ll actually contract the condition; at least 50 percent of people who have an elevated risk factor never get Alzheimer’s.

Taking into consideration medical ethics, healthcare authorities counsel against taking this blood test or undertaking other genetic testing because they want to save their patients from unwarranted fear about something that will perhaps never happen. There are others reasons for which they also advise against testing. If a person has the inherited gene or elevated risk factor, it might negatively affect their ability to acquire health insurance or long-term care.

Causes of AD

All types of dementia are a result of brain cell death. As such, Alzheimer’s Disease is also caused by brain cell death. When there is an ongoing brain cell death occurring over a period of time, then it is called a neurodegenerative disease. When the brain tissue has an increasingly smaller number of nerve cells and connections, then the total brain size shrinks due to Alzheimer’s.

Plaques in the brain are a result of the build-up of a protein called beta-amyloid (also known as “amyloid plaques”). These plaques cannot be seen or tested for in the living brain affected by Alzheimer’s Disease. A postmortem or autopsy will show these plaques and masses. Plaques are found between the dying cells in the brain.

These unusual protein clusters in the brain tissue are always present with Alzheimer’s disease. Scientists are not yet sure if there could be an additional primary activity that is really causing Alzheimer’s Disease. This sort of alteration in brain nerves is also observed in other illnesses. Researchers want to find out how these protein abnormalities progress so that a cure or treatment might be discovered. Researchers have not completely comprehended why the alterations that lead to Alzheimer’s disease befall a patient. It is known that several dissimilar factors are believed to be implicated, aging and a family history of Alzheimer’s, chief among them.

Diagnosis

Alzheimer’s disease is not straightforward to diagnose, as there is no single test for it. The first step physicians take is to rule out other complications before validating whether mental indications and signs are stark enough to be a type of dementia or something else.

Signs and symptoms [6]

Phases of Alzheimer’s Disease:

Aging has effects on memory but not AD.

• Occasionally forgetting things.
• Sometimes items are misplaced.
• Slight temporary memory loss.
• Not recalling precise particulars.

Early phase

• Not recollecting incidences of deprived memory.
• Forgetting names of family or friends.
• Only close friends or relatives may notice the changes.
• Some perplexity in conditions outside the acquainted.

Middle-phase

• Enormous effort recollecting newly acquired knowledge
• Increasing misperception in numerous situations
• Difficulties with slumber or sleep
• Difficulty in recognizing where they are

Late-phase

• Low capability to reason
• Difficulties in talking
• Retelling same dialogues
• Extra rude, nervous, or suspicious

Treatment

For Alzheimer’s there is no recognized treatment. The loss of brain cells cannot be stopped or overturned.

Drug therapy

There are no disease-altering medicines obtainable for Alzheimer’s, but some choices may decrease its symptoms and help recover quality of life. Four drugs are available. They’re called cholinesterase inhibitors. They include Donepezil (brand name Aricept), Rivastigmine (Exelon), and Tacrine (Cognex). Another type of drug, called memantine (Namenda), which is an NMDA receptor antagonist, may also be used. This drug may be used alone or with a cholinesterase inhibitor.

Other therapies

As with other kinds of dementia and neurodegenerative illness, a chief part of therapy for patients with Alzheimer’s comes from the patronage given by healthcare personnel. Quality-of-life care becomes more imperative as needs increase with diminishing freedom [3].

There are other treatments outside the US. In India, Alzheimer’s disease is treated with Ayurveda [7]. Ashwaganda, an ancient Herb used in Ayurveda, is confirmed to be a possible cure for Alzheimer’s [8]. It has also been found that Curcumin (in India it is called Haldi) is more efficient at hindering the formation of the protein fragments than many other potential Alzheimer’s treatments. Optimizing vitamin D and vitamin B12 intake, as well as a nutritious diet rich in folate and coconut oil, have also been tested as to their efficacy at treating Alzheimer’s Disease [9].

Daily mental challenges

Mental stimulation, particularly acquiring something novel, such as learning to play an instrument or a new language, is linked with a reduced risk of Alzheimer’s. Researchers theorize that mental tasks assist in developing the brain, making it less prone to the lesions connected with Alzheimer’s Disease [8].

References

1. What Is Alzheimer’s Disease? National Institute on Aging, U.S. Department of Health and Human Services. https://www.nia.nih.gov/health/what-alzheimers-disease
2. Alzheimer’s for Dummies, Patricia B. Smith, Mary M. Kenan, Mark Edwin Kunik, Leeza Gibbons. October 2003. http://www.dummies.com/health/knowing-what-alzheimers-is-and-is-not/

3. What’s to know about Alzheimer’s disease? Medical News Today. Newsletter. 13 February 2018. https://www.medicalnewstoday.com/articles/159442.php
4. About Alzheimer’s and Dementia. org. India, Alzheimer’s association. https://www.alz.org/in/dementia-alzheimers-en.asp
5. Incidence of Alzheimer’s disease in India: a 10-years follow-up study. Mathuranath PS1, George A, Ranjith N, Justus S, Kumar MS, Menon R, Sarma PS, Verghese J. Neurol India. 2012 Nov-Dec;60(6):625-30 https://www.ncbi.nlm.nih.gov/pubmed/23287326

6. Alzheimer’s disease. From Wikipedia, the free encyclopedia. https://en.wikipedia.org/wiki/Alzheimer%27s_disease
7. Treating Alzheimer’s disease with the help of Ayurveda by Hunila. November 1, 2012 org. http://www.alzheimerindia.org/treating-alzheimers-disease-with-the-help-of-ayurveda/

8. Ashwaganda: Ancient Herb Proven to be a Potential Cure for Alzheimer’s by Dr. Mercola April 07, 2012 https://articles.mercola.com/sites/articles/archive/2012/04/07/ashwaganda-effect-on-alzheimers-disease.aspx

9. Coconut Oil and Alzheimer’s Disease By anh-usa (Alliance for Natural Health) on October 5, 2010. http://www.anh-usa.org/coconut-oil-and-alzheimers-disease/

The answer to all of these questions relies on understanding certain laws in the nature. Every existence, from stars to trees, and living to nonliving, is an example of the systems in the palace of our universe.

Closed systems never engage in any exchange of matter, energy, or information with their environments. There is not any closed system in the universe. For example, a “thermos” can be a partial example of a closed system, since the liquid contained inside it does not get cold or warm quickly.

Open systems take part in matter, energy, and information exchanges with their environments. Human bodies, plants, and animals are each open systems. For instance, chemical reactions take place under our skin: enzymes constantly move, and blood is continuously flowing; via sweating, body heat is maintained; we exhale and inhale. We feed ourselves with food and beverages for our energy needs. Unwanted materials are excreted from our body.

These are necessary exchanges, but there can be exchanges for intangible realities such as ideas and love.

As a guide for understanding systems and as an indicator of irregularities, entropy finds its true meaning in the second law of thermodynamics. The entropy of closed systems increases up to a certain value and remains constant. The higher the entropy, the higher the level of irregularity.

For example, we are born in an organized state; however, as life continues, it drives our entropy higher and we leave this world at the maximum level of entropy. In other words, we posses a lower entropy when we step into this world. We mature as our entropy gets higher and we migrate into the other world with the ticket of death at the maximum form of entropy.

When the events inside and outside ourselves are halted, death becomes inevitable. It is through the uptake of materials from the outside world (oxygen, water, food, etc) that entropy slows down, so that we can sustain an average lifespan. An open system allows us to survive.

If we close the borders and cut our relations with the outer world, open systems are observed to generate entropy quickly, causing an internal disruption that may lead to death. Hadrian’s Wall of England, the Great Wall of China, and the Berlin wall of Germany can be presented as examples of detrimental functions. Similarly, the former Soviet Union was a closed system, and the hardships it caused are further evidence that such systems are not natural when they violate the second law of thermodynamics and they are not sustainable.

It is possible to talk about the entropy of any organization by looking at the level of its irregularity. A loss of variations or tensions within an organization, or an increase in the number of units, may cause an elevation of entropy.

When a living or nonliving organization approaches the moment of death, or all units become independent or equilibrated, entropy reaches its maximum value and control starts to diminish.

Conversely, if all units have a perfect interaction with the administrator and each other, this time entropy trends towards the ideal value, which is minimal, and irregularity in the system decreases.

The flow-use of energy and information is critical in organized structures such as a factory, corporation, school, government, or living organism. Upon the degradation of this state, entropy increases and efficiency decreases. If in this system there is not a structure in which information is stored, and no effective flow of information and energy is present at all stages of the hierarchy, the information from the lowest layer cannot pass through many units on its way towards the administration, and the information/energy flow among units becomes unhealthy. Entropy inevitably increases in such a process. Therefore, to ensure the proper sustainability of all organized structures, the vertical (hierarchic) and horizontal information-energy flow channels must remain open.

If work-based conflicts are experienced in between certain units in an organization (for instance, the same task is being carried out by several units) or certain jobs are being neglected, this situation refers to a major irregularity in terms of information-energy flow.

If a great portion of the power remains at the head of the structure, it is easier to make decisions and organizational efficiency is higher. The intensity of power at the lower layers of the organization therefore reduces the effectiveness of the structure, leading to chaos and disruption in information transfers.

If all units in the organization have the same authority and are equal, they are independent for all matters, this case may be classified as maximum entropy, in other words, the end of the organization.

Entropy and infinity

To understand entropy, one must consider its relation to infinity. Infinity points to a place, a situation in which an infinite amount of information is present. We can think of a book as low-entropy, organized structure where letters of the alphabet make up the words by joining together under certain rules. These words form sentences, and sentences compose chapters. Now let’s imagine that we cut the pages with a pair of scissors, and then remove words by cutting them away one by one, finally separating the words into letters. Now we are only left with a pile of letters.

At this moment, let’s ask the following question by looking at the letters collected on the table: “What do I have now?” The first answer that comes to mind will be “a pile of very scrambled letters.” But in fact, you own more than a pile of scrambled letters, since a high level of entropy also means a large amount of information.

The collection of letters on the table possesses a very large potential of information. With these letters, not only can the original book be assembled, but many books by combining the letters into different forms; this is just like in the Book of the Universe.

When the body of each organism that experiences death decays and disintegrates under the soil, it is separated into its letters – in a physical sense. Thus, each organism is converted into a potential form of information with its death. Then each part (letter) is employed for various tasks. In other words, the remnants of deceased organisms are used for writing different words, sentences, and books in the universe. This cycle points to an infinite amount of information, and infinity.

Conversion from state to state

We are moving in a state of flow towards a maximum state of entropy, carried by the execution of natural laws. In this process, almost everything is transformed from one state into another. Instantaneous renewal and growth occurs. There are parameters that we can affect in addition to the ones we cannot. For instance, once cells reach a specific size, they divide into smaller units and growth starts again. Firms, stars, and living things are like that, too. These are systems that lose energy (dissipative systems).

These systems are constantly transformed into newer states and certain dynamically-stable statuses are built. Transformations occur by arriving at branching points and many alternative states may be possible at these divergence points. Some of these states may be beneficial for the system, and some are not. However we do know that maximum entropy and making selections, whether good or bad, at the divergence points is a result of the second law of thermodynamics. For this reason, efforts to remain constantly in the stable states, which we describe as “balanced,” will mean death in some way. Try not to change, if you like. Eventually, you will witness your break down and degradation. We now recognize that human society should act as an open system. To be able survive many years, both materially and spiritually, then the exchange of information and energy should take place in a natural fashion. The spiritual guidance of the masters of faith and thought in human history teach us to be in compliance with this nature.

Furthermore, all these incidents remind us each time that balance in its absolute meaning does not exist in this world, and that it will be established somewhere else.

Reference

• Hershey, Daniel. 2010. Entropy Theory of Aging Systems, Imperial College Press.

Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences.
Jin et al. Nature Neuroscience, Jan 2014.

When we learn to play a musical instrument – say the guitar – first, we have to learn notes, scales and chords; only then we will be able to play a song. The very same rule applies to our basic functions. For example, when we learn how to read, we first learn the alphabet and the rules of grammar, and then we start making sense of sentences. Neuroscientists have been intrigued by this process for many years and they have wanted to understand how our brains efficiently perform complex cognitive functions by connecting separate elements to produce a unique meaningful sequence. A recent study shed some light on this very important question. Scientists found that a specific area of the brain, the basal ganglia, can signal the integration of individual elements into a behavioral sequence. Scientists designed an experiment where they first trained mice to perform gradually faster sequences of lever presses. This behavioral test is very similar to a person learning to play a guitar solo at an increasingly faster pace. Then, they recorded the neural activity in the basal ganglia of mice performing the task and discovered that basal ganglia neurons treat a whole sequence of actions as a single behavior. This mechanism is called “chunking,” which allows the brain to efficiently organize memories and actions by integrating individual sequences. It seems like the basal ganglia implement the “chunking.” The basal ganglia are known to include two major pathways, the direct and the indirect. Scientists found that these two pathways show similar activities during the initiation of movement, but show differential activations during the execution of behavioral sequences. Interestingly, basal ganglia circuits are implicated in Parkinson’s and Huntington’s disorders, in which learning of sequences are compromised. Further studies will reveal a more mechanistic understanding of sequence integration in the brain and potential interventions to enhance it in neurological disorders.

Single Gene Separates Queen from Workers

Ubx promotes corbicular development in Apis mellifera
Medved V. et al. Biology Letters, Jan 2014

In a hive of honey bees, the queen and worker bees have very different jobs. A new study shows that a single gene called Ultrbithrox (Ubx) separates a queen from worker bees. The Ubx gene was previously known to control leg and hindquarter development in bees. Interestingly, researchers now identified three functions for Ubx specific to worker bees. First, Ubx promotes the development of a smooth spot on the hind legs where the “pollen baskets” are located. Second, Ubx directs the formation of eleven perfectly spaced bristles on the section of the leg called the “pollen comb.” Third, Ubx mediates the formation of the “pollen press” which is a protrusion that helps pack and transport pollen back to the hive. Essentially, the Ubx gene promotes the development of three different physical structures on worker bees so that they can collect and transport pollen. Researchers confirmed these findings by silencing the Ubx gene genetically in worker bees and found that specialized leg features, including pollen combs and pollen presses, completely disappeared in the absence of the Ubx gene. Moreover, analyses of other bee species in the region revealed that the size and complexity of pollen baskets are directly correlated with the social behaviors of the particular bee species, suggesting that pollen baskets have yet-to-be-identified roles on the social behaviors of bees. Furthermore, the pollination of 35 percent of the world’s crops (with a $216 billion market value) depends on bees carrying pollen from one flower to another. This study might help us to develop new genetic approaches to make bees better, more efficient pollinators and to ultimately combat the worldwide pollination problem.

Molecular Switch in Aging Blood Cells Discovered

A canonical to non-canonical Wnt signaling switch in haematopoietic stem-cell ageing
Florian MC et al. Nature, October2013

Every single cell in our body ages over time. The aging of a cell is typically characterized by the progressive loss of physiological function and increased vulnerability to death. The aging of our cells/tissues/organs is the primary risk factor for any human diseases. One critical cell type that dramatically changes its properties during aging are blood stem cells, aka Hematopoietic Stem Cells (HSCs). Young HSCs have the capacity to differentiate into the diverse lineages of erythroid, lymphoid, and myeloid cells. Young HSCs are polarized (asymmetrical) cells, in which distinct cytoskeletal proteins (also called the “polarity complex”) are asymmetrically distributed within. However, the aged HSCs are mostly apolarized (symmetrical) cells and they differentiate only into lineages of myeloid cells (including, red blood cells, macrophages and monocytes) rather than lymphocytes (white blood cells in the immune system). The molecular changes in aging HSCs have largely been unknown. A recent study published in Nature shed some light onto the molecular identity of the ageing HSCs. Scientists showed that ageing HSCs have higher levels of a secreted protein called WNT5a, whereas the young HSCs have almost no WNT5a protein expressed in the cell. Moreover, the increased levels of WNT5a are found to attenuate the levels of the “polarity complex” proteins in HSCs and thus result in apolarized cells, which resemble the aging HSCs. Furthermore, transplantation studies revealed that increased WNT5a levels cause aging-related phenotypes and low Wnt5a levels promote a rejuvenation process in mice. These findings show that Wnt5a is the key molecule that controls the shift between young and old HSCs. Therapeutic approaches using antagonists of the Wnt5a molecule could potentially alleviate aging-related pathologies in the patients with a variety of blood diseases.

We live in a world full of technological devices, instruments and machines. Even if we buy them from good retailers, our cars we use to commute, or our CD-players and nowadays the mp3-players we use to listen to music one day break down, and eventually we change them. Can you imagine a TV which never gets old and can be used forever? The answer is obviously no. But we human beings have a miraculous system that always repairs itself-a system called DNA Repair. The proteins which are produced using DNA as a template, are also used to repair DNA when necessary. Before going into details of DNA repair, let us look at what DNA is, what DNA damage is, and how it occurs.

DNA (deoxyribonucleic acid) is one of four major macromolecules (the others being carbohydrates, lipids, and proteins) that constitute living things. DNA mainly contains genetic information encoded by a combination of four different DNA building blocks, nucleotides, to produce proteins. These proteins in turn play a role in cellular reactions. Genetic material is faithfully copied and passed on from generation to generation, perpetuating the characteristics of the parent and providing children with the information necessary for existence. Our sex, most of our personalities, as well as physical traits (eye color, hair color) are dependent on DNA as a part of the biological order established in our body. Moreover, even aging is a result of the shortening of the packed DNA (chromosome) through time. DNA is crucial for our body, but having such a unique molecule can come at a cost. In particular, cancer and many other disorders are thought to be caused by a lack of proper DNA-handling in cells, due to a defect in DNA repair.

DNA is a fairly stable molecule made up of two strands. Along each individual there are covalent bonds which hold sugar and phosphates together, and the two complementary strands of DNA are bound by hydrogen bonds. But, are these bonds strong enough? Are they unbreakable? To be able to function properly is DNA ever in need of maintenance? Like everything in this world, DNA too can be fragile in extreme conditions (Figure 1). Physical or chemical agents that might cause changes in DNA are commonly known as DNA-damaging agents or mutagens. Mutagens can be either endogenous (like free radicals which are produced from normal metabolic byproducts) or exogenous (like UV radiation or some toxic food chemicals). In addition, DNA can be damaged when synthesizing itself before cell division. These changes may be caused by enzymatic errors or mis-incorporation of nucleotides. Studies have shown that DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. While this constitutes only 0.000165% of the human genome’s approximately 6 billion bases (3 billion base pairs), unrepaired lesions in critical genes (such as tumor suppressor genes) can impede a cell’s ability to carry out its function and appreciably increase the likelihood of cancer formation.

Although there are many ways that DNA can be damaged, we are equipped with DNA repair mechanisms that can reverse the process. As soon as damage occurs to the DNA, it is detected by sensor proteins. These proteins scan the DNA all the time for any bulges or breaks. Once damage is identified the proteins tag it and DNA repair is initiated. A second precaution against damage is provided by a process called DNA Damage Checkpoint (Figure 1). Once this has been activated, cell division is delayed or comes to a halt in order to prevent the change from being passed on to any new cells.

Damage can occur on a single strand or on both strands. Depending on where or how the damage has been introduced, we have different repair systems for each type of DNA damage (Figure 2). In figure 2 we can see the difference between the original, undamaged DNA and the damaged DNA. The DNA repair systems responsible for repairing different defects are also shown in the figure to give a better idea of different DNA repair systems. Of particular interest is the fact that there are more than 150 genes that have been identified to date as being related to DNA repair. When we consider the number of possible defects that can threaten the DNA, this number is surprisingly low in comparison to the total number of genes (~ 30,000 as estimated by the Consortium of the Human Genome Project). Related to that, research in recent years has started to show that the genes which are important for one particular type of DNA repair are in fact required for different repair systems too. When we think about the enormous number of defects introduced into the DNA as opposed to the very few number of proteins involved in DNA repair (as compared to the whole genome), we can easily appreciate the perfection of the system. To give an idea of how DNA is repaired a nucleotide excision repair is shown in figure 3. At the top of the figure, UV exposure causes damage to the DNA. After that, DNA repair is initiated and recognizes the damage. The proteins (represented by circles in different colors) which are responsible for the repair act one after another to bring the DNA back to its original, intact shape.

If damage in DNA is not repaired at all, then the cells with the damaged DNA are either eliminated via a process called apoptosis or mutation occurs. The term mutation refers to permanent changes in the DNA. Although most people assume mutations are harmful, they can be silent or even beneficial depending on the region of DNA in which they occur. In the worst case, when they are deleterious, they can cause many genetically related disorders as well as cancers (Table 1). In this table, we can see different disorders which are caused by lack of appropriate repair systems.

If the rate of DNA damage exceeds the capacity of the cell to repair it, the accumulation of errors can overwhelm the cell and might also result in premature aging. Biologically, aging is an irreversible state in which the cell no longer divides, and is a protective response to the shortening of the DNA ends (telomeres). The telomeres are long regions of repetitive DNA that undergo partial degradation each time a cell is divided. Aging in cells may serve as a functional alternative to apoptosis in cases where the physical presence of a cell is required by the organism, thus serving as a “last resort” mechanism to prevent a cell with damaged DNA from dividing inappropriately. Since inappropriate division might lead to cancer, the induction of aging and apoptosis is considered to be part of a strategy to protect against cancer.

On the other hand, there is an interesting example for researchers where we see a proficiency of DNA repair activity in an organism called deinococcus radiodurans, the most radiation-resistant organism known to date. Specifically, it exhibits a remarkable resistance to radioactivity (which in turn causes double strand breaks on DNA) most likely due to enhanced DNA repair.

In this article we have tried to answer the question of what DNA repair is, how it is regulated in the cells and what the results of a deficiency in DNA repair are. Studying wonders like the DNA of our biological system is a means of contemplation that leads us to deep reflection on the intricacies of the universe. But one question remains unanswered, how has DNA learned to repair itself?

Hasan Altinbasak is a researcher at the National Institutes of Health.

References

• Lodish H, Berk A., Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J. (2004). Molecular Biology of the Cell, p. 963. WH Freeman: New York, NY. 5th ed.
• A physical map of the human genome. The International Human Genome Mapping Consortium. Nature 409, 934–941 (15 February 2001)
• http://www.riken.jp/engn/r-world/info/release/tress/2005/050609_2/index.html
• Wood RD, Mitchell M, Lindahl T. Human DNA repair genes, 2005. Mutat Res. 2005 Sep 4;577(1-2):275-83.
• Tom Strachan, Andrew Read. 2003. Human Molecular Genetics. John Wiley & Sons Inc.
• http://bbrp.llnl.gov/repair/html/overview.html
• http://biology-pages.info

However, as one’s age increases, most bodily functions peak and then start to diminish. A better aging strategy would be to age in the healthiest possible manner; i.e., keeping the physical and mental functions as sharp as possible, in particular the memory, so as not to lose human dignity in old age.

Aging and Memory

As one ages, reactions start to slow, the speed of understanding and the level of concentration diminish. The precipitous decline of dopamine-containing neurons in the human brain after age 45 is a universal characteristic of the aging process. The nigrostriatal region of the brain is richest in dopamine and undergoes the most rapid aging of any brain area. Age-associated depletion of dopamine also accounts for less noticeable symptoms, like a decline in physical drives and brain functions. These reactions are mostly on a mental or psychological level. In addition to these, wrinkles appear in the skin, hairs gray, and joints become gnarly. Perhaps, most important of all, is that according to recent research carried out on the brain, by the time most people hit 40, their brainpower starts to weaken. This does not mean that people become incompetent, just a bit slower in the cognitive process. This phenomenon is called “generalized slowing” by psychologists. According to James Birren, the Associate Director of the Center on Aging at the University of California, Los Angeles, the first signs of aging appear on tests used to measure mental speed and acuity, in which people count the number of lights flashed on a screen, for instance, or trace a complicated pattern while looking at a mirror.

“But eventually the down-turn affects almost everything we do,” says Birren, “From how fast we hit the breaks when a car pulls in front of us to how quickly we learn new skills on the job or remember old what’s-her-name’s name.”

Then the question is whether the slowing process is unavoidable. According to psychologist Robert Dustman, the answer to this is yes. One of the country’s top experts on aging and the brain, Dustman directs the Neuropsychology Research Laboratory at the Veterans Affairs Medical Center in Salt Lake City. He’s just turned 70 and shows no signs of slowing down himself. “It is true that when we compare 20-year-olds with 60-year olds on almost any test that measures the speed of information processing, younger people on average score significantly better than the older ones,” he says, “But that does not have to be. There is a simple way I can ward off the scourge of slowness,” Dustman says. And the way to do this is to stay in shape.

At first it seems to go against common sense that in some way a mindless act like jogging or striding around a park is relevant to the speed of thinking. But Dustman explains the connection in a very logical way.

Every cell in the body requires a continuous supply of oxygen and nutrients to function at its peak. But surprisingly, no cells need a greater oxygen supply than the gray matter that rests between our ears. The brain, although it makes up only 2% of our body weight, uses up 25% of the glucose and oxygen supply.

Now suppose a person slips out of shape, their heart gets lazy, the arteries get clogged, the blood flow to capillaries slows down, and the oxygen and nutrient supply to the brain falls us. As a result, neurons get less than they need to function properly, the electrical signals slow down, and hence the mind slows down. A recent study shows that blood pressure (or lack of it) is highly correlated to memory; so much so that, a reduction of it causes the memory to weaken.

But getting older does not mean that one must face a full-scale slowdown, Dustman says. The problem is that by 45, when the brain is quickly falling into decline, most of us neglect to perform the activities that keep the arteries open, the heart strong, and blood flowing; namely exercise. Dustman’s own studies suggest that working out might be an antidote. In one of his studies, he ran 60 male volunteers, half in their twenties, half in their sixties, through the standard mental tests. As expected, the younger group had higher mental speeds. But when Dustman looked closely at the older group, he noticed that the ones who were exercising or had remained active had a brain speed that was comparable to that of the younger set.

The tests included actions as simple as pushing a button each time an X appeared in a long string of O’s to memorizing numbers and symbols. “On many measures,” says Dustman “the older men in good condition scored just as well as men 30 and 40 years their junior.” In real life, that is, they could find a number in a phone book or remember that sensible is a synonym for rational.

When one exercise, in other words, the sections of the brain which control movement and balance are fired up, the electrical signals zap back and forth along the nerves from the brain to the muscles and tendons. The eyes, the inner ear, and other sensory nerves all roll into action. The benefits of these can be detected clearly in the brainwaves and electrical impulses recorded by researchers.

Indeed, in Dustman’s study, the older men who were still fit had surprisingly youthful-looking brain waves. They produced more alpha waves, a pattern associated with calmness under pressure, and had steeper peaks and valleys in waves, which signifies an ability to block out distractions. Furthermore, when subjected to a sudden flash of light or a sound blast, they were faster to produce a wave called P-300, which is associated with fast reactions. “People in good shape can really focus,” says Dustman. “They can pen a letter to a friend without the sound of children playing downstairs disturbing them. They can fill out tax forms correctly after reading the directions once.” For someone who’s out of shape, the news is grim. In addition to problems that range from overweight to heart disease and diabetes, the results of a sedentary life style, it turns out that the brain will very likely start to weaken as well. Still, Dustman is optimistic. He once encouraged 42 sedentary people over 55 to exercise (walking or jogging) three times a week. After four months, the aerobic capacity of the volunteers increased 25 % and they scored better on mental speed tests. In light of this study, Dustman thinks that even easy exercise, such as brisk walking can speed up the minds of people after years of inactivity. The time required varies, however. In similar studies, it took about a year to observe an increase in the speed of the brain.

But it is not time that is important here; the goal is rather not to lose brain capacity until a very old age. It would be better if one were always to keep in shape, as it is easier to keep something that works running than to start it up again once it has slowed down. “The real benefit seems to come from making a lifelong habit of staying active,” says Dustman.

It is better to maintain a regular routine of exercises than to start up new ones. Researchers at the University of Illinois compared middle-aged lab rats who padded daily on a running mill to rats who negotiated a complicated obstacle course of rope bridges and seesaws a few times a day. Predictably, both groups got more blood flowing to the brain. But the obstacle-mastering rats had 25% more hard-wired connections between neurons. Assuming the same is true for humans, then exercises which require more brain activity are potentially more rewarding.

Aging and Sleep

The obvious dangers of not getting enough sleep include mental fuzziness, an increased chance of accidents, illness, psychological problems, and decreased productivity at work or school. But Dr. Eve Van Cauter wrote in the prestigious medical journal Lancet that less sleep can actually speed the process of aging. In her informative study, young men who were allowed to sleep only 4 hours each night showed signs of aging in less than a week. Their glucose tolerance dropped considerably, and they started to release cortisol, the stress hormone, at a greater rate than normal.

Sleep offers the body an opportunity to heal and rebuild itself. Pro-sleep nutrients might help in this cause. For example, it has been shown that nutritional supplements containing zinc, magnesium, and pyridoxine (vitamin B6) , among other benefits, help sleep efficiency. A herbal amino acid 5-hydroxytryptophan is another promising sleep aid to use in times of extreme stress. Among sleep promoting herbs from traditional Chinese medicine are ziziphus spinosa (jujube), schisandra chinensis, and bupleurum chinense (Chinese thoroughwax). These herbs seem to relax the muscles and soothe the central nervous system. Sleep is and remains to be the most precious source of energy replenishment.

Melatonin: A God-given Sleeping Pill

Melatonin is a natural molecule made by the pineal gland, which is located in the brain. Melatonin is made from an amino acid called tryptophan. Tryptophan is an essential amino acid, that is, the body cannot make it; we need to get it from the foods we eat. Tryptophan is found in wide variety of foods. As we consume tryptophan during the day, the body converts it into serotonin, an important chemical for the brain that is involved with moods. Serotonin, in turn, is converted into melatonin. This conversion occurs most efficiently at nights.

Melatonin helps to set and control the internal clock that governs the natural rhythms of the body. Each night the pineal gland produces melatonin, which helps us to fall asleep. Research about this molecule has been going on since it was discovered at Yale University by Dr. Lerner in 1958, but recently there has been a great deal more attention being paid to melatonin. About a thousand articles on melatonin are published annually. One major reason is that scientists are discovering that melatonin is not only associated with deep sleep, but also with our hormonal, immune, and nervous systems. Research is accumulating about melatonin’s role as a powerful antioxidant, its possible anti-aging benefits, and its immune-enhancing properties.

Aging and Free Radicals

A free radical is a molecule that contains an unpaired electron through reactions with the essential element oxygen. These molecules “steal” electrons from nearby molecules to complete that final electron pair for stability. Then they are no longer free radicals, but they convert the new combined molecule into a new free radical. In a living organism, this process can cause a chain reaction of severe cellular damage, unless prevented.

The theory that free radicals are agents of bodily destruction is gaining widespread acceptance, as is the value of antioxidants in preventing such an occurrence.

According to the journal Annals of Clinical and Laboratory Science, the excess of free radicals in our body, i.e. “the domino effect”, is a critical factor in many health problems. An interesting and concerning fact about free radicals is that they cause the same reactions within the cells that occur during exposure to radiation. Free radicals released in the body destroy even proteins, the essential constituents of the body that regulate hormones and enzymes and that make up nerves, muscles, skin, and hair. It is usually suggested that antioxidants are used to fight these harmful free radicals. Fruits and vegetables are plentiful in vitamins A, C, and E, the key antioxidants. Polyphenols, which are found in grapes and green tea extracts are potent antioxidants. In fact, scientists have found out that procyanidins are the most promising polyphenols. In Japan, scientists have discovered that they may be 50 times more powerful than vitamins C and E in fighting free radicals. Alpha-lipoic acid, which is soluble in both water and lipids, can neutralize free radicals throughout the body. In fact, alpha-lipoic acid is involved in so many different antioxidant functions that it has been called the “universal antioxidant.” Citrus bioflavonoids and certain fruit and vegetable pigments are also strong free radical fighters.

Deprenyl: An Anti-aging Treatment?

Deprenyl (selegiline) provides selective protection against age-related degeneration of the dopamine nervous system. It is the only inhibitor used in clinical practice. The rate at which dopamine neurons age is quite variable. Before age 45, dopamine levels stay quite stable. Starting at 45, the decrease in average dopamine content in healthy people is linear, at 13% per decade. When it reaches 30%, the symptoms of Parkinson appear.

The sensitivity of the dopaminergic nervous system to oxidizing free radicals has been well established. The protective effect of deprenyl in lessening the neurotoxic effect of the oxidants (6-hydrpxydopa and 6-hydroxydopamine) appears to correlate with increased antioxidant enzyme levels. The increase in the antioxidant level is proportional to the deprenyl intake.

There as yet has been no definitive study of the long-term use of deprenyl in healthy people as a life-extension and cognitive-enhancing drug. But there has been extensive animal research. The lifespan of deprenyl-taking rats is significantly greater than normal rats, in fact, all the control rats died before the first deprenyl-taking rat died. Early research with deprenyl in humans (early-diagnosed Parkinson patients) shows delayed development of symptoms. Deprenyl has also been established as a treatment for Alzheimer’s disease. Eventually, deprenyl has the potential of becoming a general treatment for aging in people above the age of 45.

Conclusion

Although we know for sure that there cannot be an absolute cure for aging, the results of it can be slowed down considerably. Soundness and health of mind are desirable traits for all ages, not just for the elderly. After many years, many elderly people lose much of their memory and mental capacities; this occurs just at the time when they can pass on all their wisdom and experience to the younger generations. Hopefully, with the advent of science and technology, the deficiencies in the brain due to aging can be avoided to a certain extent. The solution lies in a balanced collaboration of modern medicine and traditional natural cures that have been practiced for centuries.

References

• Life expectancy around the world http://www.mrdowling. .com/800life.html
• Peter Jaret, (1997) THINK FAST- from Health Magazine, http://www.brain.com/TFarticle.html
• Ray Sahelian, M.D., (1997) “Melatonin: Nature’s Sleeping Pill,” http://www.brain.com/melatonin.html
• Ward Dean, M.D., and Steve Wm. Fowkes. “Deprenyl: A Universal Anti-aging Strategy?,” http://www.ceri.com/ deprenyl.htm
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