Alzheimer’s disease is “an irreversible, progressive brain disease that slowly destroys memory and thinking skills, eventually even the ability to carry out the simplest tasks” according to the Alzheimer’s Association. Alzheimer’s affects mostly senior citizens, and symptoms first appear in most people between 60 and 70. The first signs of Alzheimer’s, though, can be noticed between the ages of 30 and 65. However, it is very rare for younger people to exhibit symptoms. Most cases of dementia are caused by Alzheimer’s disease [1]. It is known that all Alzheimer’s patients have dementia; however, one cannot say that all dementia patients have Alzheimer’s disease. Alzheimer’s is a deadly disease, finishing predictably in death [2].

Alzheimer’s disease is named after Dr. Alois Alzheimer. In the early twentieth century (1906), Dr. Alzheimer observed alterations in the brain tissue of a woman who had expired of an uncommon mental disease. Her signs involved loss of memory, language difficulties, and erratic conduct. After her death, Dr. Alzheimer inspected her brain and discovered many uncharacteristic clusters (now called amyloid plaques) and scrambled packets of filaments (now called neurofibrillary, or tau, tangles) [1].

Based on his findings, he correctly theorized that these anomalous buildups were accountable for the patient’s loss of memory and other mental complications.

The plaques and tangles in the brain are some of the foremost characteristics of Alzheimer’s disease. Another characteristic is the damage of contacts between nerve cells (neurons) in the brain. Neurons conduct communications between different segments of the brain – for example, they conduct communications from the brain to muscles and organs in the body. Many other multifaceted brain alterations are thought to play a function in Alzheimer’s disease.

In the beginning, this impairment seems to take place in the hippocampus of the brain. The hippocampus is the part of the brain that is indispensable in forming memories. When neurons perish, further parts of the brain are distressed. In the last stage of Alzheimer’s, destruction is extensive, and brain tissue has shortened substantially.

How many Americans have Alzheimer’s disease?

It is estimated   that more than 5 million Americans may have Alzheimer’s disease. If existing population developments continue, the number of people with AD will increase significantly. However, this trend can be stopped if the disease can be effectively treated or prevented.

The reasons people develop Alzheimer’s are still not fully understood. One known reason is aging.   Age is the most significant accepted risk factor for Alzheimer’s disease. In 2010, in the United States, close to 5 million people 65 years and older were living with Alzheimer’s illness. A 2013 report from the Alzheimer’s Association suggests that 1/10^th of all Americans over 65 are suffering from Alzheimer’s. The proportion goes up to about a third of the population for those who are over 85. According to the Alzheimer’s Association, AD incidence is between 60% and 80% of all incidents of dementia [3].

Incidence of Alzheimer’s disease in South Asia

Globally, at least 44 million individuals live with dementia, making the disease a worldwide health catastrophe that must be tackled. In excess of 4 million individuals have some appearance of dementia in India [4].

In the Southern Indian state of Kerala, 1066 qualified members who were cognitively regular at reference, 104 of them acquired dementia (98 of them were found to have AD) over a continuation time of 8.1 years. The occurrence rates per 1000 person-years for AD was 11.67 for persons aged ≥55 years and greater for those aged ≥65 years (15.54). Individuals who were aged ≥65 years, the global age consistent occurrence rate, was 9.19 per 1000 person-years, prevalence rate of AD raised substantially and proportionally with growing age. These are the initial AD occurrence rates to be conveyed from southern India. When compared to reports from rural North India these occurrence rates appear to be much greater. But they are comparable with those reported from China, and slightly lesser than that reported from the western world [5].

Signs of Alzheimer’s disease

Memory difficulties are characteristically one of the first signs of Alzheimer’s; nonetheless, early indications may differ from individual to individual. A decrease in other facets of thinking, for example forgetting words, sight/three-dimensional problems, and diminished thinking or decision making, may additionally indicate the precise initial periods of Alzheimer’s disease. Mild cognitive impairment (MCI) is a disorder that can be an initial mark of Alzheimer’s. However, not everyone with MCI will develop Alzheimer’s.

Patients with Alzheimer’s have difficulty performing routine things like paying bills, driving a car, or cooking food. They repeatedly ask the same questions, go astray without difficulty, misplace things or put them in unusual places, and find even easy things puzzling. As the disease advances, some patients become anxious, wrathful, or furious.

Longevity of a person with Alzheimer’s disease?

At the time of diagnosis, if the person is older than 80, they are only likely to live another three or four years. If the person is younger then 80, they could live for as many as ten years or more.

Currently Alzheimer’s disease is graded as the sixth greatest cause of death in the United States. But fresh evaluations show that the illness may be listed as third, after heart disease and cancer, as a source of death for elderly people.

At the present time, there is no cure for Alzheimer’s. However, treatment can help patients cope with symptoms [1].

In the 21^st century, Alzheimer’s can only be diagnosed with 100 percent precision through a postmortem examination that discloses the occurrence of the distinctive plaques and tangles. However, a complete examination and suitable checkup can afford a dependable diagnosis with better than 90 percent certainty.

Malformed accumulations of particular proteins inside the brain interrupt normal brain performance and produce the reasoning and efficient difficulties characteristically connected with Alzheimer’s Disease. Ultimately, as the sediments expand all over the brain, brain material begins to die. This results in additional intellectual damage. CT scans and MRI scans show the subsequent brain contraction. CT scan shows enlargement of the ventricles in the brain and loss of brain tissue in a patient with Alzheimer’s disease. Recent research is endeavoring to ascertain what produces these accumulations and is watching for techniques to avoid or change them before they cause lasting brain destruction [2].

Alzheimer’s is not curable.
Alzheimer’s is not contagious.
Alzheimer’s is not a natural part of the aging process.
Alzheimer’s is not something you get from using deodorant or cooking in aluminum pans.
Alzheimer’s is not inevitable if you live long enough.

In some families, Alzheimer’s disease is hereditary. But these appearances are very rare, and they account for fewer than five percent of all incidents. If a family member like a mother or a brother has Alzheimer’s disease, it doesn’t inevitably mean that you’re prone to contract it as well.

There is no test that can foretell whether you’ll get Alzheimer’s disease, save tests for the very rare hereditary Alzheimer’s. A blood test can tell whether you have a certain form of cholesterol-carrying protein connected with an elevated occurrence of the disease. This examination can’t convey whether you’ll actually contract the condition; at least 50 percent of people who have an elevated risk factor never get Alzheimer’s.

Taking into consideration medical ethics, healthcare authorities counsel against taking this blood test or undertaking other genetic testing because they want to save their patients from unwarranted fear about something that will perhaps never happen. There are others reasons for which they also advise against testing. If a person has the inherited gene or elevated risk factor, it might negatively affect their ability to acquire health insurance or long-term care.

Causes of AD

All types of dementia are a result of brain cell death. As such, Alzheimer’s Disease is also caused by brain cell death. When there is an ongoing brain cell death occurring over a period of time, then it is called a neurodegenerative disease. When the brain tissue has an increasingly smaller number of nerve cells and connections, then the total brain size shrinks due to Alzheimer’s.

Plaques in the brain are a result of the build-up of a protein called beta-amyloid (also known as “amyloid plaques”). These plaques cannot be seen or tested for in the living brain affected by Alzheimer’s Disease. A postmortem or autopsy will show these plaques and masses. Plaques are found between the dying cells in the brain.

These unusual protein clusters in the brain tissue are always present with Alzheimer’s disease. Scientists are not yet sure if there could be an additional primary activity that is really causing Alzheimer’s Disease. This sort of alteration in brain nerves is also observed in other illnesses. Researchers want to find out how these protein abnormalities progress so that a cure or treatment might be discovered. Researchers have not completely comprehended why the alterations that lead to Alzheimer’s disease befall a patient. It is known that several dissimilar factors are believed to be implicated, aging and a family history of Alzheimer’s, chief among them.

Diagnosis

Alzheimer’s disease is not straightforward to diagnose, as there is no single test for it. The first step physicians take is to rule out other complications before validating whether mental indications and signs are stark enough to be a type of dementia or something else.

Signs and symptoms [6]

Phases of Alzheimer’s Disease:

Aging has effects on memory but not AD.

• Occasionally forgetting things.
• Sometimes items are misplaced.
• Slight temporary memory loss.
• Not recalling precise particulars.

Early phase

• Not recollecting incidences of deprived memory.
• Forgetting names of family or friends.
• Only close friends or relatives may notice the changes.
• Some perplexity in conditions outside the acquainted.

Middle-phase

• Enormous effort recollecting newly acquired knowledge
• Increasing misperception in numerous situations
• Difficulties with slumber or sleep
• Difficulty in recognizing where they are

Late-phase

• Low capability to reason
• Difficulties in talking
• Retelling same dialogues
• Extra rude, nervous, or suspicious

Treatment

For Alzheimer’s there is no recognized treatment. The loss of brain cells cannot be stopped or overturned.

Drug therapy

There are no disease-altering medicines obtainable for Alzheimer’s, but some choices may decrease its symptoms and help recover quality of life. Four drugs are available. They’re called cholinesterase inhibitors. They include Donepezil (brand name Aricept), Rivastigmine (Exelon), and Tacrine (Cognex). Another type of drug, called memantine (Namenda), which is an NMDA receptor antagonist, may also be used. This drug may be used alone or with a cholinesterase inhibitor.

Other therapies

As with other kinds of dementia and neurodegenerative illness, a chief part of therapy for patients with Alzheimer’s comes from the patronage given by healthcare personnel. Quality-of-life care becomes more imperative as needs increase with diminishing freedom [3].

There are other treatments outside the US. In India, Alzheimer’s disease is treated with Ayurveda [7]. Ashwaganda, an ancient Herb used in Ayurveda, is confirmed to be a possible cure for Alzheimer’s [8]. It has also been found that Curcumin (in India it is called Haldi) is more efficient at hindering the formation of the protein fragments than many other potential Alzheimer’s treatments. Optimizing vitamin D and vitamin B12 intake, as well as a nutritious diet rich in folate and coconut oil, have also been tested as to their efficacy at treating Alzheimer’s Disease [9].

Daily mental challenges

Mental stimulation, particularly acquiring something novel, such as learning to play an instrument or a new language, is linked with a reduced risk of Alzheimer’s. Researchers theorize that mental tasks assist in developing the brain, making it less prone to the lesions connected with Alzheimer’s Disease [8].

References

1. What Is Alzheimer’s Disease? National Institute on Aging, U.S. Department of Health and Human Services. https://www.nia.nih.gov/health/what-alzheimers-disease
2. Alzheimer’s for Dummies, Patricia B. Smith, Mary M. Kenan, Mark Edwin Kunik, Leeza Gibbons. October 2003. http://www.dummies.com/health/knowing-what-alzheimers-is-and-is-not/

3. What’s to know about Alzheimer’s disease? Medical News Today. Newsletter. 13 February 2018. https://www.medicalnewstoday.com/articles/159442.php
4. About Alzheimer’s and Dementia. org. India, Alzheimer’s association. https://www.alz.org/in/dementia-alzheimers-en.asp
5. Incidence of Alzheimer’s disease in India: a 10-years follow-up study. Mathuranath PS1, George A, Ranjith N, Justus S, Kumar MS, Menon R, Sarma PS, Verghese J. Neurol India. 2012 Nov-Dec;60(6):625-30 https://www.ncbi.nlm.nih.gov/pubmed/23287326

6. Alzheimer’s disease. From Wikipedia, the free encyclopedia. https://en.wikipedia.org/wiki/Alzheimer%27s_disease
7. Treating Alzheimer’s disease with the help of Ayurveda by Hunila. November 1, 2012 org. http://www.alzheimerindia.org/treating-alzheimers-disease-with-the-help-of-ayurveda/

8. Ashwaganda: Ancient Herb Proven to be a Potential Cure for Alzheimer’s by Dr. Mercola April 07, 2012 https://articles.mercola.com/sites/articles/archive/2012/04/07/ashwaganda-effect-on-alzheimers-disease.aspx

9. Coconut Oil and Alzheimer’s Disease By anh-usa (Alliance for Natural Health) on October 5, 2010. http://www.anh-usa.org/coconut-oil-and-alzheimers-disease/

As human life expectancy has grown longer, it has led to the emergence of disease that were once quite rare. One of these is Alzheimer’s. At the beginning, Alzheimer’s manifests as a decrease in overall everyday activity. It becomes more apparent as mental functions decrease and cognition weakens. In advanced stages, it leads to senility, a tragic condition induced by the deterioration of neurons.

Memory loss is a leading symptom that emerges at the onset of the disease. At first, past memories remain intact and little memory lapses occur. Then mental abilities gradually disappear. Speaking and hand gestures, which are primarily controlled by the frontal and temporal lobes of the brain, start to fail, accompanied by problems with recognition.

Although the underlying pathological processes in the brain tissues are not completely identified, it is known that there are disconnections between the limbic system and the frontal and temporal lobes. The intensive deterioration of the side cortical regions (the temporoparietal cortex) becomes visible in the amyloid plaques and the coiling nerve fibers as neurons degenerate and advance toward death.

Causes of Alzheimer’s

The exact cause of the disease is not known. It is in 2-4% of people over 65, and this rises to 20% of people over 85, indicating the relationship of the disease with advanced age. 1-5% of the cases are known to arise from genetic factors. A dominant mutation was identified in three different genes in a few cases diagnosed in the early stages of disease. A gene called ApoE was identified to be oversensitive in patients diagnosed with the more common type of Alzheimer’s at later ages.

One of the hypothesized causes is prions, proteins 100 times smaller than viruses that became known thanks to mad cow disease. Neither a virus nor a bacterium, prions are pathogens formed by the mutation of normal proteins produced in neural cells. Prions can be contagious. It is believed that prions can pass from person to person during a blood transfusion or dental treatment through unsterilized tools.

Dementia might be a single disorder for the layperson, but in medicine it refers to several disorders with different underlying causes. Alzheimer’s dementia is one of the neurodegenerative diseases in which neurons are destroyed; it is classified separately from frontotemporal dementia, dementia with Lewy bodies, dementia from Parkinson’s disease, vascular dementia, and dementia originating from Multiple Sclerosis (MS) or a metabolic disorder.

Demographic studies have identified several factors that increase the risk of Alzheimer’s disease. The energy source of neurons can be disrupted because of a decrease in blood flow into the brain resulting from circulatory damage, especially in patients who have high blood pressure and are overweight. Therefore, recommendations for a healthy way of life hold true for this disease.

The disease, which gradually destroys the neurons and the brain, severs the connections between cells. A typical symptom of the loss of neurons in Alzheimer’s begins with the loss of the sense of smell. The death of the cells spreads slowly to regions associated with memory and then to the entire brain surface. One-fifth of brain mass might be lost as a result.

The olfactory (smell) center and the bottom part of the brain are affected at an earlier stage. The Meynert basal nucleus in the central nervous system produces a substance (neurotransmitter) required for communication between neurons. The presence of this substance is important for retrieving memories from the archives – that is, for remembering. An apparent decrease in acetylcholine levels prevents processing of information, and because short-term memory is negatively affected, it may become very hard to remember events that have only recently happened.

As losses increase, the acetylcholine produced in the basal nucleus decreases. A remarkable finding about Alzheimer’s is the protein buildup in neurons and gaps in certain regions of the brain. Some doctors believe that this protein buildup causes the disease, while others argue that it is the body’s response to the disease. The result is the same: protein plaques act like poison that damage the metabolism of neurons, and the patient’s cognitive performance decreases because neurons cannot communicate with each other.

Increasing risk for relatives

Kinship seems to be an important risk factor for almost a third of Alzheimer’s patients. The probability that an Alzheimer’s patient’s siblings and children will have the disease is four times higher than for other people. The genes that indicate genetic factors have been identified in some families. For example, the epsilon-4 allele is found in 40% of Alzheimer’s patients, while it is present only in 10% of the healthy population. Yet this finding does not necessarily mean that everyone who has this gene will get sick. As researchers put it, the highest risk factor for Alzheimer’s is age. The older a person gets, the greater the risk of developing Alzheimer’s. Although the effect of gender is not exactly known, women have been found to be twice as likely to have the disease.

Among factors that increase the risk of Alzheimer’s are nicotine, alcohol, obesity, high cholesterol levels, diabetes, thyroid function disorders (hypo- or hyperthyroid), frequent concussions, unhealthy diet, heart attack, and paralysis. It is also interesting that depression, anxiety, and increased nervousness may develop at the onset of the disease.

Alzheimer’s and loneliness

In Alzheimer’s as well as other types of dementia, dementia is found to be triggered by lack of mental activity, which is in part connected to loneliness and isolation from people. In fact, loneliness is considered to be a preliminary symptom of Alzheimer’s. A study performed with 79 older people (43 female and 36 male) who had symptoms of dementia found that the amount of amyloid plaque was seven times higher in the brains of the participants with a greater decline in mental abilities. In addition, these patients suffered from severe cases of loneliness.

Is poor sleep a risk factor?

Observations in sleep laboratories indicate that prolonged periods of poor sleep increase the risk of Alzheimer’s. Even a single restless night without deep sleep can increase the beta-amyloid concentration, or Alzheimer’s protein, in the brain fluid. In case of several subsequent nights of restless nights, an increase is observed in the levels of tau protein, a second protein associated with the illness. The findings obtained by a team of specialists led by David M. Holtzman from Washington University Department of Medicine show that sleep disorders that are untreated for a long time increase the risk of Alzheimer’s.

The brain may not be cleaned sufficiently without deep sleep, hence the increase in the levels of protein particles. Yet it has been found that the amounts of beta-amyloid return to normal after a few days of sound sleep. The risk increases after a prolonged lack of deep sleep. It is thus believed that the risk of Alzheimer’s increases in people with sleep apnea who wake up repeatedly during the night because of problems breathing.

Yet it is not clear whether the increase in the amounts of tau and beta-amyloid proteins is related with the onset of the disease and how the findings should be interpreted. The reason for the confusion is that the two proteins also change shape and cause buildups in healthy people, not just in patients. It is therefore not known whether risk of Alzheimer’s can be lowered with a night of sound sleep.

We can say that warning signs can be found in sleep. Neuroscientists at the University of Toronto have discovered one of the early signs of sleep behavior. They have found that people who beat or kick themselves in their dreams are 80-90% more likely to develop a neurodegenerative disorder such as Parkinson’s and dementia at a later age, and this condition, also known as REM sleep disorder,[1] could be early signs of a brain disorder that may emerge within fifteen years.

Another study by Boston University researchers has revealed a correlation between REM sleep and Alzheimer’s. The researchers have found that a reduction in REM or dream-sleep phase increased the risk of disease. On the other hand, not every nightmare is a symptom of the disease. The predictive factor is the desire to move taking place during REM sleep. We spend about a quarter of our sleep in the REM phase.

The more efficient the sleep, the less the amyloid plaques

How long we sleep at night might predict how well our memory will work when we get older. According to Dr. Yo-Elju, sleep disorders seem to contribute to the formation of amyloid plaques. A two-week study conducted at the Faculty of Medicine at Washington University in St. Louis collected data from about 100 people aged 45-80. Researchers used sleep behavior surveys and machine measurements. A quarter of the participants had signs of amyloid plaques.

The participants spent eight hours a night in bed. They were disturbed by being woken at different intervals. It was seen in the end that those who were woken more often had greater amyloid plaques. Interestingly, those who slept more than 6.5 hours had the same condition. The correlation between poor sleep and amyloid plaques is striking, yet the findings in this study do not provide evidence for a cause-effect relationship. Therefore, longitudinal studies are needed to find out whether sleep disorders contribute to formation of plaques in the brain. To sum up, these studies indicate that quality of sleep matters more than length of sleep. It seems more important to have a shorter sleep with a complete REM phase than a ten-hour sleep without REM sleep.

An important advice

It is important for families to take care of their elderlies in their old age. It is worth noting that the Qur’an refers to weakness of mental faculties in old age followed by an advice to give in charity and reminding of His favors including spouses, children, and good, healthy sustenance:

God has created you, then He causes you to die. And among you are those who are deferred to the age of senility so they do not know, of what they once knew, anything at all. Surely God is All-Knowing, All-Powerful. And God has favored some of you above others in provision. And yet (while it is We Who provide them), those who are more favored do not consent to share their provision with those (slaves) whom their right hands possess, so that they might be equal with them in this respect. How then do they deny God’s grace and bounty (and associate partners with Him)? God has made for you, from your selves, mates (spouses), and has made for you from your mates children and grandchildren, and has provided you with good, wholesome things. Do they, then, believe in falsehood and deny the blessings of God? (16:70-72)

This allusion to family as a favor makes much sense thinking of the huge difference in the quality of life and health the elderlies have depending on the company of children and grandchildren and the lack thereof. As an example, I can cite my own father who lived to the age of 102 with his six children and fifteen grandchildren in the same apartment building. He never felt loneliness thanks to his many visitors, who conversed with him every day. He never became senile. 

Another interesting point to note is that this chapter of the Qur’an is Nahl, which means “honeybee.” Considering the fact that the main nutrition for our brain is glucose, consumption of honey and other food mentioned in the same chapter, like dates and grapes, may be considered useful to prevent mental diseases like Alzheimer’s.

References

Nancy J. Donovan ve ark. (2016): Association of Higher Cortical Amyloid Burden with Loneliness in Cognitively Normal Older Adults. JAMA Psychiatry, 2016; DOI: 10.1001/jamapsychiatry.2016.2657.

[1] REM (rapid eye movement) sleep is the period of sleep that starts 30-90 minutes after falling asleep in which one has dreams. This phase of deep sleep takes up about 20% of one’s overall sleep. It is the most refreshing period of sleep during which muscles are completely relaxed, eyelids move rapidly, and noradrenalin and serotonin are absent.

Original Article: Ramirez G. et al., Science 331, 211 (2011).

We have had to deal with tests and exams in academic and professional life from childhood on. Though we are motivated to perform our best, the pressure-filled situations generally cause us to perform below our abilities. University of Chicago researchers were interested in finding an intervention that would improve performance under such conditions, especially for those students who do not do well on exams because they are blocked by anxiety. Their study showed that simply writing down our thoughts and concerns immediately before a high-stress event can increase performance from 5–12 percent when it matters most. The simple brain-focusing exercise of writing down feelings for ten minutes before an exam reduces anxiety and increases exam scores significantly. The researchers concluded that writing allows individuals to reexamine the situation and revaluate concerns, reducing anxiety and increasing one’s ability to focus. This type of writing may help people perform their best not only on tests but also in variety of high-stress situations—a big presentation to a client, a speech to an audience, or even a job interview.

2- Life Without Starlight

Original Article: Hooper, D. & Steffen, J.H. (arXiv:1103.5086v1).

Liquid water is considered the common solvent to catalyze carbon-based life on planets. This assumption defines a rather tight region around stars, which is called the “habitable zone.” The energy absorbed from the host star through its light allows planets in the habitable zones to melt water into liquid. Water would either evaporate or remain ice if the planet is too close to or distant from the star. A recent study suggested that starlight may not be the only energy source that can convert ice into liquid water and maintain it in that state. Dark matter annihilation may produce enough heat in special circumstances for planets that may not be sufficiently heated by their host star. Ordinary matter constitutes only about 20 percent of the matter in the universe, while dark matter makes up about 80 percent of all matter. It is believed that dark matter weakly interacts with atomic nuclei. Therefore, one of the leading models for dark matter is called “weakly interacting massive particles” (WIMPs). In cases where dark matter interacts with nuclei, WIMPs can transfer momentum to the nucleus. Then they can get gravitationally captured and subsequently decay as energetic particles. This process can produce heat as a consequence. On Earth, the concentration of dark matter at its center is not sufficient to produce observable contributions to the planet’s total heat budget. However for planets around stars that are closer to the centers of their galaxy, where the concentration of dark matter is significantly higher, just enough heat may be produced by gravitationally captured and annihilated dark matter. The abundance of planets detected by NASA’s satellite mission-Kepler suggests that perhaps life in the universe might be more abundant than we thought.

3- How Much Digital Information Can Mankind Store?

Original Article: Hilbert, H. & López, P., Science 332, 60 (2011).

Have you ever wondered how much total information is stored by human beings? We store information in two different forms: analog storage such as books, printed photos, and audio cassettes, and digital storage such as hard drives, CDs, DVDs, and the like. A recent paper analyzed how the total information storage and processing ability of human beings changed between the years of 1986 and 2007. The study estimated that the total information stored as of 2007 is 295 exabytes. An exabyte is equal to one million terabytes or one billion gigabytes. If all this information was stored on CDs, this stack of CDs would reach beyond the moon. If it was stored in books, it would be enough to cover the entire United States with 13 layers of books. Interestingly, the information stored by DNA in one single human body is about 300 times larger than the entire amount of information stored by humanity. In 2000, only 25 percent of known information was stored in digital form; this ratio increased to 94 percent in 2007. The area in which the “information revolution” is most evident is computation. The study found that the global computing capacity increased by 58 percent per year during this time. But even at this fast rate of growth, in 2007 the total instructions per second that humankind can carry out on its general-purpose computers were about the same as the maximum number of nerve impulses executed by one human brain per second.

4- Tricking the Brain to Attack Alzheimer’s Disease

Original Articles: Atwal, J. K. et al., Science Translational Medicine 3, 84ra43 (2011) & Yu, Y. J. et al., Science Translational Medicine 3, 84ra44 (2011).

Alzheimer’s disease affects many people, especially in later stages of life, and as the lifespan of humans increases, it becomes much more prevalent everyday. The primary cause of Alzheimer’s disease is unknown, but scientists generally associate the disease with the appearance of plaques and tangles in brain cells, often caused by a protein called amyloid. Hence, a natural strategy would be to attack these proteins that form these plaques. Yet, the biggest obstacle in our brain is the blood-brain barrier, which prevents viruses and other unwanted visitors from entering our most delicate organ. Scientists have tried to overcome this barrier with many different drugs and strategies, but there is no clear winner yet. Two recent studies reported in Science Translational Medicine journal give us a new hope in our fight against Alzheimer’s disease. Scientists devised a clever strategy to trick the gatekeepers of the blood-brain barrier into escorting antibodies against the Alzheimer’s-associated proteins. This method reduced the levels of amyloid by up to 50 percent inside mouse brain cells. Designed antibodies had two arms—one arm to target the enzyme, BACE1, which produces the amyloid, and the other arm to bind to the transferring receptor, which in turn deceived the endothelial cells from the blood-brain barrier to internalize the antibody. There are many other brain disorders that we have a limited arsenal against because of the blood-brain barrier. Hence this new method can be used for these diseases, which opens up a whole new venue of targeting strategies.

These special functions are responsible for analyzing sensory data, performing memory functions, learning new information, forming thoughts, and making decisions. Given this, cognitive science deals primarily with the functioning of the brains frontal lobe, which is responsible for cognition (the act or process of knowing, including both awareness and judgment) and memory. The brains prefrontal area enables concentration, attention, and the elaboration of thought. As the brains gatekeeper (judgment and inhibition), it also is responsible for personality and emotional traits. One of the frontal lobes main functions is memory, a very important topic in cognitive science.

Memory

Memory is defined as the power or process of reproducing or recalling what has been learned and retained, especially through associative mechanisms. It is also the store of things learned and retained from an organisms activity or experience, as evidenced by structure or behavior modification as well as recall and recognition.

Just like any other human trait, memory can be empowered and improved. How this is accomplished usually depends upon the individual. Many such techniques and tricks are advertised and marketed in daily life. While some actually work, most are like overloading our already full memory files. Eventually, it comes down to tricks vs. power, just like in sports. Consider the following analogy: If an Olympic boxer wants to improve his skills, should he watch pro-boxing matches on TV or punch a vinyl speed bag to train the muscles he needs to overpower his opponent?

This example might seem a little strange, for it depends heavily upon muscles. But, surprisingly, it really is relevant to the brains memory center, for recent developments in cognitive science show that a specific area behind the forehead (in the pre-frontal cortex) houses the brains memory muscle (1) ”the working memory. The discovery was made possible by advances in such brain-imaging technologies as PET and MRI scans.(2) Suppose you are studying for an exam and have to wade through a mound of reading material, or have to make a 10-digit phone call without the aid of a phone book, or are under a lot of pressure to answer questions rapidly or to make a snap decision. It is your working memory that decides what is relevant and where to best store such data for quick retrieval upon demand.

Developing our memory muscle

Pharmaceuticals, memory books, mnemonic tricks, seminars, and mental chronometrics (3) say that we develop our memory muscle and thereby improve our memory power. In reality, our memory muscle is our heads chief executive, for it is in charge of receiving, organizing, encoding, filing, and retrieving just about anything we learn, as well as for all planning and decision-making activity.

This activity is also known as psycho-interactive intelligence, for such tasks challenge all of the powers of working memory, including short-term memory, concentration, and mental speed. Computer-based exercises (CBEs) function in the same way. And, since they are psycho-interactive, they customize new challenges via simultaneous analysis and measurement. In addition, they usually are far more entertaining.

In fact, our memory muscle actually determines how quick, sharp, and focused our thinking is. According to Life magazine (July 1994): Evidence is accumulating that the brain works a lot like a muscle”the more you use it the more it grows. Although scientists had long ascertained that the brains chemistry was hard-wired by adolescence and inflexible in adulthood, its newly discovered ability to change, grow, and adapt is apparently with us well into old age.

NASA continues to make extensive use of training exercises to improve the brainpower of astronauts and pilots. Computer models of the brains functioning also are used in determining how to improve brainpower. Due to such research, they have been able to tap and train the brains memory muscle.

Mind Machines and Pharmatronics

The term mind machines refers to a large variety of technologies that affect ones brain: HemiSynch tapes, light and sound machines, cranial electrical simulation (CES) devices, biofeedback, biocircuits, lucid dreaming tapes and machines, consciousness alteration software, and sensory deprivation tanks. They are designed to transform the users brain waves into a wide variety of new patterns: from focused and alert to creative and ultra-relaxed, meditative to twilight receptive/learning state, or to different states of sleep. It is like instant brainwaves–ready in seconds on demand.

Bio-entrainment is the process of causing neurons to function in a desired manner. For example, a person with attention deficit disorder (ADD) cannot focus due to slow theta rhythms and desynchronous beta waves. Mind machines, especially light/sound and biofeedback, can help break these brain waves out of their scattered gridlock and drive them into open focus (theta) or closed focus (beta) patterns. Bio-entrainment also can enable people to focus better, relax or dive into deep meditation, induce creative or intuitive states, or to enter a deep sleep state quickly.

Encouraged by mind machines, pharmatronics (neuroscience) has induced researchers to postulate the psycho-physiological principle: Every psychological state has a corresponding measurable physiological (i.e., physical, electrical, and biochemical) state, and vice versa. For instance, using biofeedback to reach a state of deep relaxation and serenity (i.e., meditation) may cause the pituitary gland to produce endorphins that make you feel real good. This electronic-to-pharmacological effect, known as pharmatronics, is like an electronic drug or a device (e.g., a computer, game player, biofeedback device, or even software), for it alters the brains electrical (brain wave) pattern and, hence, its biochemical (pharmacological) profile.

One of the first notable pharmatronic agents was Tetris, a computerized puzzle game. Using PET scans, Dr. R. Haier discovered that first-time Tetris players experienced a significant increase in their cerebral glucose metabolic rate (GMR), indicating that their basic brain energy consumption was soaring.(4)

Computer-based exercises (CBEs)

Psycho-interactivity is not the same as interactivity. Clicking on a hyperlinked button to go to another page is interactive, whereas a psycho-interactive activity involves a computer taking the user through a series of mental challenges. But it does not stop there, for it also analyses the individuals reactions and then adjusts the level of complexity in subsequent challenges to ascertain the full potential of the players memory recall, thinking, and decision-making speed. Thus it renders a dynamic brainpower analysis, whereas most mental ability tests are static.

Since the brain is like a muscle, it must be challenged with the appropriate kind of resistance if it is to develop and grow. To develop any muscle, one has to engage in anaerobic exercises that feature a resistance or load that is very difficult to lift more than 10 to15 times (reps). Aerobic exercises (e.g., using a weight that you can lift 100 times), will not develop the muscles power. This is also true with the brain, for it will not develop only by thinking harder (an aerobic activity). What it requires is an anaerobic-like challenge, such as learning a new skill. Playing chess or mastering a new judo move can stimulate the brains neural dendrites to grow. However, the best anaerobic exercise is one that challenges the person to exert maximum mental energy, like running the 100-meter dash instead of a mile. This is what CBEs do.

CBEs also lower the noise in the brain, which leads to a more accurate reading and processing of information. The brains learning and testing is much like computers”its power is indicated by its speed, efficiency, and capacity for reading, filing, and recalling information.

CBEs are a synthesis of cognitive science, educational psychology, computer science, biofeedback, and psychophysiology. In addition to psycho-interactivity, add the law of psycho-physiology: If you can receive immediate on-line measurement of anything, whether it is your heart rate or brain waves, you can control it.(5)

In one experiment, astronauts used cognitive challenges every day and reported back to Houston so that their brains functioning could be recorded for that day. Subtle changes in cabin CO2, CO, ionization, and so on were found to have measurable effects on their brainpower and performance. CBEs do something like this, but their interactivity makes them more challenging and allows researchers to determine good or bad days in terms of brainpower.

Physical, perceptual, and cognitive reflexes are important in athletics. Contrary to common belief, reflexes can be trained and improved. There is plenty of research on how diet and nutritional supplements effects mental and physical performance. But training can sharpen and hone all of three reflexes. Psychology and physiology books say there is a limit to how fast one reacts to a simple stimulus, such as a car suddenly stopping in front of you on the freeway. The limit is assumed to be 150 milliseconds. But CBEs have reduced this to 100 milliseconds.

CBEs can improve perceptual reflexes (seeing speed). Moreover, some cognitive reflexes, strangely enough, are not highly correlated with physical reflexes. Just because an athlete has good hand-eye coordination and reflexes does not guarantee athletic success when the reaction is based on making a split-second cognitive choice or decision. Cognitive reflexes also can be improved.

Brain software in clinical studies

CBEs that analyze the brain and compute the users IQ may have an important role in studying and detecting Alzheimers, a progressive brain disorder. Josh Reynolds points out that while Alzheimers only affects 4 to 5 million people in the US, PMI (Premature Mental Impairment) is estimated to afflict over 50 million Americans. PMI typically manifests itself as loss of sustained concentration, memory, and mental quickness. It has many causes, such as undetected strokes, poor nutrition, head injury, alcohol and tobacco abuse, and depression.

However, the most prevalent cause of potentially serious brain deterioration may be cortisol, an adrenal hormone produced as a byproduct of stress. Recent research suggests that cortisol may actually kill brain cells and even lead to Alzheimers if the stress is not detected and treated. Ironically, the very medications used to treat stress (e.g., Valium) temporarily impair physical and cognitive reflexes, especially when dosages are too high or mixed with other drugs or alcohol.

CBEs can show the subtle early stages of stress-related memory loss, and can be used to titrate the dosage levels of anti-anxiety and anti-depressant drugs. Thus, they can minimize the temporary impairment mentioned above while maintaining the medications therapeutic efficacy. CBEs are developed on a computer science platform and thorough research into cognitive chronometrics, defined as the direct active computer-assisted measurement of the brains function. CBEs also can diagnose the early stages of a brain disorder before the onset of clinical symptoms. In addition to Alzheimers, CBEs are used to study and detect ADD and head trauma recovery.

The early stages of dementia, especially Alzheimers, are typically characterized by a breakdown in short-term memory. The primary breakdown is believed not to be in memory retrieval, but in the memory consolidation and storage phase, which are believed to be delegated to the hippocampus. According to CDI president Josh Reynolds, one of the earliest markers of Alzheimers is in the cholnergic system in the hippocampus.

PMI is characterized by a loss of sustained concentration, memory, and mental quickness. CBEs assess six areas of neuro-cognitive functions: physical reflexes, perceptual reflexes and thresholds, cognitive reflexes, working memory capacity (short-term memory), neuro-cognitive processing efficiency (concentration/attention), and neuro-cognitive processing speed (mental quickness). This is accomplished by measuring cognitive states (or status) and subtle changes in cognitive states.

CBEs also provide a reflective measure of neural noise, which is measured by analyzing, among other proprietary variables, the standard deviation (consistency) of the subjects intra-trial reaction times.

Conclusion

As in any field of science and life, computers are becoming a ubiquitous element in cognitive science. With its potential prospects and uses, the computer continues to offer many opportunities to improve our life. This article focused on some of the ways in which a computer can be used to aid the brains memory function. However this is just a crawling stage, and the field essentially remains wide open for researchers.

Footnotes

1. The term memory muscle is used here for the resemblance of this area of brain to a muscle in terms of functioning.
2. PET (Positron Emission Tomography) involves producing a computer-generated image of a biological activity within the body by detecting gamma rays emitted when introduced radionuclides decay and release positrons. MRI (Magnetic Resonance Imaging) involves using a nuclear magnetic resonance spectrometer to produce electronic images of specific atoms and molecular structures in solids, especially human cells, tissues, and organs. Cognitive scientist Dr. Richard Heier of the University of California, Irvine, is a prominent figure in this area.
3. Mental Chronometrics: A field within cognitive science that uses computer assisted brain exercises to interactively isolate, challenge, and develop working memory.
4. Phil Sater is a pioneer in neuro-technology and light and sound Personal Relaxers. He also is involved in developing an L/S TurboCharger. See www.mindgear.com.

5 Josh Reynolds is the founder of www.brain.com.

References

• http://at-advocacy.phillynews.com/data/brain.html.
• McCrene, John. New Scientist. Apr. 1996.
• Quarterly Report. The Long Beach Business Journal. Nov. 1997.
• www.brain.com.
• www.mindgear.com.