We all may appreciate the difference between the positive impact made by a smile of pearly-white teeth and the repulsion triggered by yellowed and blackened rotten teeth, but the health issues run much deeper: as our medical knowledge grows, we are discovering that many diseases originate from dental cavities where microbes teem and nest, causing inflammations in many organs and tissues, most notably in the heart, kidneys, and joints.

The use of herbal sticks for cleaning teeth dates back to around 3500 BC, the time of the Babylonians. In several works of Ancient Greek and Roman literature, chewable sticks to aid dental and mouth hygiene are mentioned [1]. Hippocrates (355 BC) advises rubbing a ball of cotton wrapped around a stick and dipped in honey on teeth, to maintain dental hygiene, whereas Romans used pastes obtained from gumwood [2]. Dental hygiene is coming throughout history.

Arabs utilized the miswak for many years [3]. The Japanese used wooden sticks called “koyoji” and Jews used wooden sticks called “kesam.” In the 1920s, in some rural areas across the United States, a stick of blood-twig was used for rubbing on the teeth [3]. And according to a Chinese encyclopedia published in the seventeenth century, the first-ever toothbrush was made in China, in 1498.

Prophet Muhammad, peace be upon him, warned those of his Companions who visited him with bad teeth about the need for dental hygiene (Ahmad ibn Hanbal, Musnad 1/214):

“I oft reiterated my recommendations to you about the miswak.” (Bukhari, Jum’a 8; Nasai, Taharah 5; Ahmad ibn Hanbal, Musnad 3/143; Darimi, Wudhu’ 18)

“(The Archangel) Gabriel counseled me to use the miswak so much that I thought a verse might be revealed about the miswak to decree its use as obligatory for all.” (Ibn Majah)

Obviously he assigned the utmost importance to dental hygiene. It should be noted here that the Araq tree (Salvadora persica) from which the miswaq is obtained has features that are not present in other trees, and the Prophet particularly specified using the roots of that tree as the miswak.

Research has been conducted to discover the scientific and modern medicinal effects of the miswak, which has been used by Muslims in adherence to the Prophet’s practice. In 2010, a Ph.D. study at Karolinka Institute, Sweden, provided a significant message about its effectiveness [4] (Picture 1).

The Araq tree, which is used as the miswak across a geography spanning from Africa to the far east, is a short tree or bush with a slanted trunk, and it is easy to chew its spongy roots, parts of which generally expand and soften when dipped in water (Picture 2).

The roots of the Araq tree are washed to remove the soil, and approximately 1 cm from the tip of the root stick is peeled to be used as the toothbrush. The stick is pummeled or chewed until the fibers become softer (Picture 3). Fresh and soft miswak are preferable: If the miswak is dry, it is advised to dip it in freshwater for 24 hours before use. It is better to peel frequently, so the tip is renewed. The most practical advice is to use the peeled tip until it loses its tang and fragrance, because the fragrant components indicate the beneficial effect of the miswak. According to a study, using the same tip for more than 24 hours lowers its cytotoxic ability to get rid of microbes.

The practice of using miswak in the Muslim World is widespread in Asia, Africa, and some regions in the Middle East. As many Muslims opt for miswak use to maintain a practice of the Prophet, the World Health Organization (WHO) also advises and encourages the use of miswak as an effective dental hygiene tool along with the conventional toothbrush. The miswak is easy to use and effective; it also has chemical properties that help control dental plaque. Based on the basic information we have about the miswak, we can easily say that deeper research is needed for its different components, like its fibers, essence, and essential oils.

Antibacterial effects of the miswak

The antibacterial activities of the essences obtained by crushing different roots of the miswak have been analyzed by microbiological techniques. It was discovered that the miswak essence has a very strong antibacterial effect, predominantly against Gram-negative bacteria, including mouth-cavity microbes like Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Two additional studies conducted on five different types of bacteria i.e. Streptococcus mutans, S. faecalis, S. aureus, Haemophilus influenzae, Salmonella enterica, and Candida albicans, and a type of fungus [5, 6, 7, 8] revealed that the miswak essence stops the reproduction of micro-organisms, has a lower effect on Lactobacillus acidophilus, is active against Herpes simplex virus which causes blistered lesions, and suppresses acid production.

The essential oil obtained from miswak essence includes 70% benzyl isothiocyanate, 9.4% limonene, 8.7% I-pinene and 2.55% flavonoid. As the miswak’s main antibacterial component, benzyl isothiocyanate kills bacteria by forming protrusions on their cell membranes. The volatile nature of this substance may open doors to new practices requiring antibacterial treatment. It has been proven that fresh miswak is effective at preventing the formation of dental plaque and gum inflammation, and it has also been acknowledged that it may play a potential role in preventing periodontal diseases.

The miswak essence hinders acidic (pH) conditions causing tartar and dental plaque, leads to a long-term increase of pH in the mouth, stimulates saliva flow in the parotid glands (located in front of both ears), and prevents tartar formation.

It is necessary to conduct further lab and clinical research to augment the positive results shown so far about the effects of the miswak against the inflammation of the palate and gums, as well as its antiviral and antifungal activities. Some research has additionally suggested that the miswak has antioxidant, analgesic, and anti-inflammatory effects. It is claimed that potassium chloride, salvadourea (a urea derivative), alkaloids, and oleic and linoleic acids in the miswak sap increase the viscosity of saliva, helps it to soak into hard-to-reach corners in the mouth, and contributes to overall dental hygiene. It is reported that a substance named Xylitol in the miswak essence suppresses acid production and the reproduction of mutant streptococci [9, 10].

An interesting substance in the miswak oil

Benzyl-isothiocyanates are effective molecules in the defense systems of several plants such as cabbage, watercress, and broccoli. Secreted after damage to plant tissues, benzyl isothiocyanate forms a protective antibacterial layer on the damaged part of the plant. While dental plaque and tartar are mechanically removed by rubbing the miswak on teeth, this action also helps the substance secreted from the miswak reach deeper parts of the oral cavity. It is especially proven that benzyl isothiocyanates are strongly effective as bactericide on Gram-negative bacteria and have minimal effect on Gram-positives.

Lab tests conducted on animals indicate that these components also have anti-carcinogenic activity, and people who get isothiocyanates by nutrition have a lower risk of cancer. It is fascinating that the miswak, too, has the same substance.

While introducing a new set of ethical principles, Prophet Muhammad, peace be upon him, revoked some customs and habits inherent to the pagan culture before Islam (Age of Ignorance) and kept others. Using miswak was a practice among the Arabs in the region; the Prophet encouraged its use and emphasized its benefits. Eventually, Muslims have adopted it as not only a habitual practice, but also as a healthy spiritual activity and are keeping the memory of the Prophet alive.

References

1. Wu, C.D., Darout, I.A. and Skaug, N. (2001): Chewing sticks: timeless natural toothbrushes for oral cleansing. Journal of Periodontal Research 36, 275-84.
2. Hyson, J.M., Jr. (2003): History of the toothbrush. Journal of the History of Dentistry 51, 73-80.
3. Bos, G. (1993): The Miswak, an aspect of dental care in Islam. Medical History, 37, 68-79.
4. Sofrata, A. H. (2010): Salvadora persica (Miswak). An effective way of killing oral pathogens. Thesis for doctoral degree (Ph.D.). From the Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
5. Al-Lafi, T. and Ababneh, H. (1995): The effect of the extract of the Miswak (chewing sticks) used in Jordan and the Middle East on oral bacteria. International Dental Journal, 45, 218-222.
6. Almas, K., Al-Bagieh, N. And Akpata, E. (1997): In vitro antimicrobial effect of extracts of freshly cut and 1-month-old miswak (chewing sticks). Biomedical Letters, 56, 145-149.
7. Almas, K. (1999): The antimicrobial effects of extracts of Azadirachta indica (Neem) and Salvadore persica (Arak) chewing sticks. Indian Journal of Dental Research, 10, 23-26.
8. Almas, K. (2001): The antimicrobial effects of seven different types of Asian chewing sticks. Odontostomatolgie Tropicale, 24, 17-20.
9. Kakuta, H., Iwami, Y., Mayanagi, H. and Takahashi, N. (2003): Xylitol inhibition of acid production and growth of mutans Streptococci in the presence of various dietary sugars under strictly anaerobic conditions. Caries Research, 37, 404-409.
10. Miyasawa, H., Iwami, Y., Mayanagi, H. and Takahashi, N. (2003): Xylitol inhibition of anaerobic acid production by Streptococcus mutans at various pH levels. Oral Microbiology and Immunology, 18, 215-219.

There is a natural healing power in honey of great benefit to man. This is affirmed in verses 68-9 of sura al-Nahl in the Qur’an: And your Lord inspired the bee: ‘Build your homes in the mountans and in the trees and in the (hives) made by mankihd’ Then (He taught the bee) to feed on every kind of fruit (of the earth) and to follow the ways of your Lord made smooth. There comes from inside their bellies a drink of diverse colours in which is healing for mankind. Surely in this is a sign for those people who reflect (al-Nahl, 16.68-9)

It is extraordinary that the curative properties of honey are documented in the world’s oldest medical literature. The Sumerians, and Egyptian physicians around 2000 BC, used honey to treat internal and external wounds, ulcers, diseases of the eyes, lungs, skin and, in particular, diseases of the stomach and intestines. The Chinese, the Indians, the Greeks and the Romans also recorded similar practices in their traditions. Hippocrates, the so-called ‘father’ of modern medicine (460-377 BC) also used honey to treat a variety of diseases. Honey was also highly regarded as a tonic to preserve youth and prolong healthy life–one Chinese Emperor used it as a drug to obtain immortality. The great Muslim physician, Ibn Sina (980-1037) wrote dozens of prescriptions containing honey in his world-famous medical textbook ‘The Canon of Medicine’. He is reported to have included among the benefits of honey that it makes you feel happy; that it refreshes you; that it assists digestion and gets rid of wind; that it helps when you have a cold; that it increases appetite; that it improves and sharpens memory; that it eases the tongue (the faculty of speech); and that it preserves youthfulness.

THE ANTIBACTERIAL ‘SYSTEM’ IN HONEY

In 1937 H. Dold et al. reported that honey has antibacterial activity and called the active agent an ‘inhibine’. Ever since, a number of scientist have tried in vain to discover the identity of this ‘inhibine’. In 1963 J.W. White et al. suggested that the ‘inbibine’ is the hydrogen peroxide produced by the honey’s glucose-oxidase system. However, results obtained by the author and by other scientists such as O.B.O’L. James et al. in 1972 and S.S. Radwan et al. in 1984 do not agree with the attribution of the ‘inhibine’ to the hydrogen peroxide produced. This author’s researches in the laboratory have shown that the antibacterial activity of honey is owed not to a single factor but to a complex ‘system’ of factors, of which there are at list three:

1- The high sugar concentration (76 g/1OO ml)

2- The acidity (pH=3.6-4.2)

3- The organic antibacterial compounds present in honey

It was observed that undiluted honey clearly exhibits antibacterial activity. The bacterial cells dry out because of the osmotic effect of the high sugar content in the solution and bacterial growth is retarded in the acidic environment which honey provides. In diluted form neither the sugar in the honey nor the acidity in it has an inhibitive effect on bacteria. Is it then the organic compounds which are responsible for inhibiting bacterial growth? It was also observed that most of the common pathogenic bacteria which infect human beings are killed in honey. Honey therefore acts as a bactericide. The researches established that the ‘inhibine’ is not a single agent but a subtle combination of intricately related factors quite unique in their antibacterial action. Further research is necessary, and is currently in progress, to identify the chemical nature of the organic antibacterial factors in honey.

THE BIOCHEMICAL COMPOSITION OF HONEY

The biochemical composition of honey is relevant to its curative properties. Beside the existence of the antibacterial ‘system’, honey is known to contain not less than 181 different compounds. These can be classified as follows:

– Simple and complex sugars

– Organic acids

– Minerals and trace elements (resembling blood composition)

– Vitamins (both water and fat soluble)

– Amino-acids (both essentials and non-essentials)

– Proteins (mainly enzymes)

– Lipids (simple, complex and wax)

– Plant flavours and colouring materials

– Hydrocarbons

– Hormones

– Pollens

– Microorganisms (yeast)

The list above shows just how complex the composition of honey is. It is then less of a wonder that honey contains some combination of elements which have proven so effective in the treatment of wounds and ulcers. Honey not only keeps ruptured cells sterile but also provides all the necessary micronutrients which are the building materials need to assist the cells’ full recovery. Although these micronutrients are present in only small quantities, they are available in the most easily assimilated, soluble forms. In addition, the high energy required for the healing processes to occur is provided by the simple sugars, fructose and glucose, in honey.

CLINICAL USE OF HONEY

To date the scientific and clinical evidences for the miracle of honey are numerous. Doctors and surgeons have used honey in their medical practice and even openly recommended its use. Among recent examples the use of honey for:

Treatment of serious gunshot wounds by Prof. S.A. Simirnov in 1948;

Treatment of breakdown surgical wounds by Dr. D. Cavanagh et al. in 1970;

Treatment of ulcers, surface wounds, cuts and abrasions by Dr. R. Blomfield in 1973;

Treatment of bacterial gastro enteritis (diarrhea) by Dr. I.E. Haffejee and Prof. A. Moosa in 1985;

Treatment of a wide range of serious long-standing wounds and ulcers by Dr. S.E.E. Efem in 1988;

Treatment of infected wounds in vulvectomy, infected perineum, infected abdominal wall wounds and breakdown of abdominal wall scar by Dr. R.J.F. Mclnerney in 1990.

In each of these cases honey was praised for its effectiveness as compared to ‘modern-conventional’ treatment. Honey was observed to kill bacteria at the site of wounds, to debride (clean up) wounds, rapidly replacing sloughs (dead cells) and so enabling granulation (scar) tissues to form. Honey also permitted epithelialization (i.e. growth of healthy cells) and the absorption of oedema (swellings) from around the ulcer margins. Honey reduced further infection, the risk of offensively smelly (seriously infected) wounds and so reduced need for skin graft treatments.

CONCLUSION

The verses of the Our’an which affirm the healing properties of honey affirm for us the mercy of Allah, Creator and Sustainer of the Worlds. It is also by this mercy that we study and research what He has created and made intelligible to us, including this miracle of honey. It is easy then to conclude our work, as Muslim scholars and scientists always used to begin their work, by praising Allah, and by saluting the Prophet Muhammad, upon him be peace, who left us this advice: Whoever licks honey three mornings in a month is saved from serious illnesses. 

REFERENCES

• IOYRICH, N. (1977) Bees and People, Mir Publishers. Moscow.
• CRANE, E. (1978) Honey: A Comprehensive Review Heinemann, London.
• WHITE. J.W., Mary. J.R.. Subers. H. and Schepartz, A. I. (1963) ‘The identification of inhibine, the antibacterial factor in honey as hydrogen peroxide and it s origin in a honey glucose-oxidase system’, Biochem. et Biophys. acta, 73. pp.57-70.
• JAMES. O.B. O’L, Segree. W and Ventura. A.K. (1972) ‘Some antibacterial properties of Jamaican honey’ West Indies Medical Journal, 21(7), pp.7-17.
• RADWAN. S.S.. El-Essawy, A. A. and Sarhan, M.M. (1984) ‘Experimental evidence for the occurrence in honey of specific substances active against micro-organisms’ Zbl. Mikrobiol.. 139. pp.249-55.
• KAMARUDDIN. M.Y., Sivanaesan,L and Hamid, A.H.A. (1989) ‘The existence of antibacterial factors in Malaysian Apis cerana honey’, Proceedings of the 14th. Malaysian Biochemical Society Conference pp.l8l-5
• JAVANAGH. D., Beazler, C. and Ostapowicz, F. (1970) ‘Radical operation for carcinoma of the vulva: a new approach for wound healing’ Journal of Obstetrics and Gynaecology of the British Commonwealth, 77, pp 1037-40.
• BLOMFIELD, R. (1973) ‘Honey for decubitus ulcers’ Journal of American Medical Association 224, p-905.
• HAFFEJII, I.E. and Moosa, A. (1985) ‘Honey in a treatment infantile gastroenferitis’ British Medical Journal, 290, pp.1866-7.
• EFEM. S.E. (1988) ‘Clinical observations on the wound healing properties of honey’ British Journal of Surgery, 75, pp.679-81.
• MACINERNEY. R.C.F. (1990) ‘Honey: a remedy rediscovered’, Journal of the Royal Society of Medicine, 83, p.127.
• KAMARUDDIN, M.Y (1987-91) ‘Biochemical and Pharmacological study on Malaysian Apis cerena honey’, Beekeeping: The Malaysian Beekeeping Research and Development Team – IDRC. 1987-91 Report.