In his Twentieth Word, Bediuzzaman Said Nursi, a 20^th century Islamic scholar and teacher, uses an interesting phrase, where he argues that the miracles of the prophets represent the highest points that scientific developments would ever attain and as such, they are set as goals which humanity should seek to accomplish. In interpreting the verse about the miracles of Jesus, upon whom be peace, in which it is said that Jesus would raise people from the dead by God’s leave, Bediuzzaman Said Nursi indicates that there is a cure to every disease which can be found through research. He also employs an interesting phrase in this section: “It is even possible to give a temporary tinge of life to death” [1]. While some suggest that with this intriguing sentence Nursi points to recent developments in medicine such as those involving organ transplantation or the use of ventilators, it appears that this phrase implies going one stage further.

The Holy Qur’an relates several miraculous events regarding raising the dead in the present, worldly life. In Chapter Baqara (2:67-73), the Holy Qur’an tells us of the incident upon which the chapter was named: Prophet Moses, upon whom be peace, and his people were told by God to slaughter a cow and strike a dead person with part of the slaughtered cow, afterwards the dead man was resurrected and told them who had killed him. Thus, the Qur’an reasserts that God Almighty has the power to resurrect people. Reflecting on this verse, Fethullah Gülen maintains that in addition to the miraculous nature of striking the dead body with a piece of the cow, the mention of this incident may imply that humanity is guided toward a scientific or technological goal [2]. In medicine, biological drugs used to treat certain diseases are produced from certain animals. Also, certain medications, such as insulin, can be produced making use of the ability of bacteria to produce genetically coded proteins. Perhaps, biological drugs to be obtained with the help of other living organisms may contribute to being able to give a temporary tinge of life to death. In this regard, researchers are particularly interested in stem cells and their potentials. In this method, it may be possible to use a person’s stem cells to produce organs, tissues, and replace malfunctioning organs with new ones without the risk of rejection. We have so far heard no positive results in these directions, but it was demonstrated that stem cells taken from a person and transplanted into an embryo of another living being started to grow [3]. God knows best, but this method may be part of the truth behind the act of striking the man’s corpse with a part of a cow in reference to the verse in question.

Chapter Baqarah gives two more examples concerning resurrection in worldly life. A man passed by a town that had fallen into utter ruin and asked himself in bewilderment, “How will God restore life to this town that is now dead?” God made him remain dead for a hundred years and then raised him to life, and asked him, “How long did you remain in this state?” He said: “I remained so for a day or part of a day.” God said, “No, you have rather remained thus for a hundred years. But look at your food and drink: it has not spoiled; and look at your donkey!” The verse tells us that only bones were left of the donkey (2:259).

The next verse is about Prophet Abraham, upon whom be peace, who prayed God to give him certainty in the heart about resurrection. He had to kill four birds and then put them on different hills which resulted in them being restored to life and flying back to him (2:260). While it may not be related to resurrection fully, the story of Ashab al-Kahf (“People of the Cave” or “Seven Sleepers”) is certainly intriguing and carries a similar theme. God made seven men fall sleep in a cave for roughly 300 years and then restored them to life temporarily, however they had believed that they had fallen asleep for only a very brief period. They were probably considerably skilled and well-educated young people with high positions in society, however falling asleep for three centuries caused them to lose their positions and possibly disappoint those who had invested in them at that time. Yet God Almighty’s wise purpose requires otherwise by making those people send a message to future generations, i.e., us, and giving them praiseworthy remembrance after their death. The same sura also describes the travels of Prophet Moses, upon whom be peace, accompanied by Yusha’ ibn Nun, during which the cooked fish they were carrying with them for supper was resurrected and swam into the sea (18:61-64). In a tradition of Prophet Muhammad, peace and blessings be upon him, it is recorded that he talked to a dead girl by God’s leave upon her parent’s request, but the girl refused to come back to this world as she had found something better there [the Hereafter] [4]. 

The prevention of aging, alongside the wish to attain immortality, has long been one of the greatest aspirations of human beings. Several scientists and philosophers of the previous century argued that this might become possible in the 21st century. Chapter Baqarah refers to a prototypical society with greed for life, noting that people of that society wish “if only [they] might be spared for a thousand years” (2:96). Perhaps, the ultimate goal of today’s medical research is to try to ensure human beings live forever in this world. Prophet Muhammad, peace be upon him, warns that this is a vain thought, although we should seek healing by all possible means: “O servants of God, search for remedy for your diseases. Indeed, God has created no incurable disease except one: old age (or, death, in another narration)” [5]. Nobel laureate Alexis Carrel maintained that human cells are immortal under favorable conditions but Leonard Hayflick, later, demonstrated that cell divisions are limited due to DNA damage and shortening of telomeres [6, 7]. According to the Hayflick limit, the maximum lifetime a person can get even if he or she lives under the best conditions is 125 years. Telomeres are the structures located at the end of the chromosomes that protect DNA, and during cell regeneration, the length of telomeres decreases with each cell division and the number of divisions declines after a critical limit. Scientists dream of slowing down the aging process by reactivating these telomeres, but they have not made much progress despite some positive results in experiments with rats.

Big technological corporations have recently been making considerable investments in order to find ways to further increase human lifespan. Venkatraman Ramakrishan, who won the Nobel Prize in chemistry in 2009, said, “Californian billionaires are having such a good time at the party of life that they don’t want it to stop” [8]. The investments and efforts in this field do not seem very promising because the human body is not suitable for immortality. Instead, scientists are pursuing the idea of merging human brains with machines, which would require uploading a human brain to a computer. In today’s world where research on artificial intelligence is rapidly advancing, a human being’s habits and memory are supposed to be transferred to a computer. Elon Musk, the founder of Neurolink, a company that seeks to restore memory using gadgets planted into the human brain, once said that digital intelligence and biological intelligence would converge over time with increased interaction between the two. This sounds promising for the treatment of certain diseases such as Alzheimer’s. There is, however, another lead in this research according to Josh Bocanegra: “When the time comes and all the necessary advancements are in place, we’ll be able to freeze your brain, create a new artificial body, repair any damage to your brain, and transfer it into your new body” [9]. This may be an artificial body developed using stem cells with possible aid from diverse robotic devices. Ray Kurzweil, who works on Google’s machine learning project, argues that the use of tiny robotics that connect a human brain to computers may be possible by 2029, which will in turn extend human lives considerably. Another futurist, Ian Pearson predicts that in 2050, humans will achieve virtual immortality and a person’s personality transferred to a computer will be able to communicate with people in the future [9]. A recent New York Times article suggests that brain implants could change humanity [10].

Ultimately, it is hard to predict the extent of scientific and technological developments. The idea of eliminating death reminds us of Bediuzzaman Said Nursi’s saying that it is impossible for the lake of Barla (the town he lived in at the time) to be destroyed for the time being, but people can imagine such destruction and this imagination does not change the reality. Yet even the very imagination of eliminating death may serve as a false hope for people who rationalize everything and try to forget about the idea of death, and in this way, they stick to worldly pleasures more fervently. At this point, Prophet Muhammad, peace be upon him, shows us the correct manner of thinking: “Remember death frequently as it dulls out pleasures” [11].

In the Qur’an, the most important verses concerning raising the dead are about the miracles of Jesus, upon whom be peace. It is emphasized that he would breathe into something fashioned out of clay in the shape of a bird, and it would become a bird by God’s leave, and that he would revive the dead and heal ill people (3:49). As a matter of fact, Mary becoming pregnant with Jesus and Jesus speaking when he was a baby are also medical miracles. It is interesting to note that today, just as in the time Jesus, materialistic thought dominates the scientific and medical research, which are mostly construed solely with a materialist perspective. Almost all discoveries are used as evidence for disbelief, and they reinforce the self-conceit of those who make them. Bediuzzaman predicts that as Christianity will be purified from superstitions in the End Times, and that science will have the upper hand in rule and power. If such a purification will occur, then one tends to think it is not going to be only in political and administrative fields. Possibly, the change of scientific, or more specifically, medical perspective may constitute a major stage in the purification process that could save modern medicine and science from materialism and become instruments of discovering the truth. Who knows? God Almighty may make a vulnerable and weak baby speak to send a message to a purely materialistic community as a manifestation of His divine power.

References

1. Bediuzzaman Said Nursi, 20th Word, First Station, Words.
2. Fethullah Gülen, Kurandan İdrake Yansıyanlar.
3. https://www.nytimes.com/2017/01/26/science/chimera-stemcells-organs.html
4. Bediuzzaman Said Nursi, 19th Letter, Letters.
5. Bukhari, Tib 1; Abu Dawud, Tib 1; Tirmidhi, Tib 2.
6. Carrel A, Ebeling AH. Age and multiplication of fibroblasts. J Exp Med 1921.
7. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965.
8. https://www.livemint.com
9. https://www.entrepreneur.com/article/307675
10. https://www.nytimes.com/2020/08/28/opinion/sunday/brain-machine-artificial-intelligence.html
11. Tirmidhi Hadith No. 2307.

In 1981, scientists discovered ways to derive embryonic stem cells from early mouse embryos. Since then, they have been the subject of intense scrutiny, controversy, and advocacy.

They are unique cells, which can be derived from human embryos and can be differentiated into virtually any kind of different cells. In humans, there are about 200 different types of cells including bone, muscle, and nerve cells, and within these cells there are about 20 different types of structures or organelles. Essentially, stem cells can be derived from human embryos, and with the right enzymes, can be stimulated. For instance, bone cells can originate from osteocyte cells, or liver tissues can come from hepatocytes.

Stem cell types and research

There are three types of stem cells:

• Embryonic stem cells
• Adult stem cells
• Induced Pluripotent Stem Cells (iPSC)

Embryonic stem cells are derived from human embryos. Adult stem cells are undifferentiated cells (meaning “clean slates” with the potential to change into another cell variant) found throughout the body after development; they multiply via cell division to replenish dying cells and regenerate damaged tissues. Induced Pluripotent Stem Cells (iPSC), which were discovered in 2006, are derived from skin or blood cells that have been reprogrammed back into an embryonic-like pluripotent state that enables the development of an unlimited source of any type of human cell needed for therapeutic purposes. While these types of cells are interesting and certainly worthy of research, this article will focus on embryonic stem cells as they are consistently the most well-known and discussed type by the general public.

Embryonic stem cells are potent and often sought after due to their abilities to proliferate without limit and contribute to any cell type. However, with great power comes great responsibility and stem cells are no exception. Poorly processed cells have been documented to mutate into cancerous tumors that can wreak havoc upon people’s bodies. Bearing this in mind, scientists also do not believe that this should derail stem cell therapies considering that there are DNA tests to check if stem cells will turn out to be problematic or not.

The stem cell project is regularly a subject of ethical debate in both the academic and public sectors. Most embryonic stem cells are derived from embryos that develop from eggs that have been fertilized in vitro—in an in vitro fertilization clinic—and then donated for research purposes with the informed consent of the donors. People willingly donate their eggs for this research, and this process does not constitute child-killing since the eggs are near their zygote phase, not a whole mature embryo. Scientists obtain those types of cells from an embryo which has not yet completed its formation to develop into a human being. Researchers then use these cells for various treatment and research purposes. It is important to stress that they are not derived from eggs fertilized in a woman’s body and that they are produced in a plastic laboratory culture via clinics in vitro.

Some examples of embryonic stem cells being used in research include the following:

1. UCLA stem cell gene therapy cures bubble baby disease

Researchers at UCLA (University of California, Los Angeles) have developed a cure for babies born with Bubble Baby Disease, a rare and life-threatening condition that can be fatal within the first year of life, by using stem cells from multiple patients and gene therapy to correct the genetic mutation of these patients.

2. Asterias biotherapeutics restores some independence to those suffering from paralysis caused by spinal cord injuries

Asterias Biotherapeutics spent much of 2016-2017 developing a stem cell therapy to restore upper body motor function to quadriplegic spinal cord injury victims. Through lengthy and rigorous testing in human clinical trials, the therapy was found to be safe for use in people with all patients treated reporting at least some improvements. Asterias is now expanding its clinical trials to include patients with sub-acute injuries.

3. UC Irvine scientists engineer stem cells to destroy cancer

In a study conducted by University of California, Irvine researchers, a stem cell-based technique was devised to find and destroy breast cancer cells that had already metastasized. The cells “feel” the stiffness of the surrounding tissues and destroy the cancer-causing cells.

Embryonic stem cells can remain undifferentiated when they are grown in a well taken care of culture that is under stable conditions. Problems primarily begin to arise if cells are allowed to clump together to form embryoid bodies in which they begin to differentiate, or change into more specific cell variants, spontaneously. Although spontaneous differentiation is a good indication that shows which cultures of embryonic stem cells are healthy, the process is uncontrolled and, therefore, an inefficient strategy to produce cultures of specific cell types.

The ability of stem cells being able to differentiate into hundreds of other types of cells continues to amaze scientists as this is no small discovery. Researchers believe that the possibilities with stem cells are near endless, especially in regard to “regenerative medicine,” the process of “replacing, engineering, or regenerating human cells, tissues, or organs to restore or establish a new function.” It is even believed that even whole organs could be synthetically grown by using them.” Additionally, stem cells have the potential to rebuild healthy tissues, help people with heart disease, diabetes, ALS, Alzheimer’s disease, liver disease, Parkinson’s disease, cancer, and many more illnesses.

In a stem cell transplant, embryonic stem cells are first specialized into the necessary adult cell type. Then, those mature cells replace tissue that is damaged by a disease or injury. This type of treatment could be used to:

• Replace neurons damaged by spinal cord injury, a stroke, Alzheimer’s disease, Parkinson’s disease, or other neurological problems.
• Produce insulin that could treat people with diabetes and heart muscle cells that could repair damage after a heart attack
• Replace virtually any tissue or organ that is injured or diseased.

Sometimes scientists use stem cells as a drug. For example, it is possible to inject a stem cell into joints to reduce swelling and pain, or in order to promote the healing processes of soft tissues. Stem cell therapy is performed by injecting the patient’s own stem cells to stimulate the body to repair and replace damaged tissue in any joint or soft tissue structures – such as knees, shoulders, hips, wrists, ankles, elbows, tendons, ligaments and non-healing bone fractures. Cellular Dynamics, a large biotechnical company, sells human heart cells called cardiomyocytes that are derived from induced pluripotent stem (IPS) cells. Pharmaceutical companies are adapting to this new and innovative trend on a day-to-day basis. Stem cells can also be used to test the quality and safety of investigational drugs by testing them on stem cells that have been transformed into tissue-specific cells. Researchers are able to monitor the side effects before exposing the drug to a patient and thus have a greater expectancy of how their body may respond to the drug. This allows us to test for cures for potentially fatal diseases in ways that would otherwise be risky or unethical.

With all of the aforementioned advantages, stem cells are a fairly new, but exceptionally promising, research area. For some people, it may seem unethical to use stem cells on the grounds that extracting stem cells damages the blastocyst, which is a structure formed in the early development of mammals, more specifically the sixth or the eighth day of the development of an embryo. In 2006, President Bush vetoed the Stem Cell Research Enhancement Act stating that the federal government should not support “the taking of innocent human life.” Although stem cells are very promising for science and can open new doors to many new treatments in the medical field, it looks like there are still differences of opinion on their ethical use. This is perhaps because there is need for more convincing evidence or people are not informed accurately on the details of this research area.

References

• https://stemcells.nih.gov/info/Regenerative_Medicine/2006Chapter1.htm
• https://www.healthline.com/health/stem-cell-research
• https://www.statnews.com/2017/04/26/stem-cells-cancer-mutations/
• https://plato.stanford.edu/entries/stem-cells/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398703/
• https://www.mayoclinic.org/documents/the-amazing-stem-cell/doc-20249792
• https://www.unmc.edu/stemcells/educational-resources/history.html
• https://www.cirm.ca.gov/patients/power-stem-cells
• https://www.nature.com/news/stem-cells-take-root-in-drug-development-1.10713
• https://hsci.harvard.edu/examining-ethics-embryonic-stem-cell-research#:~:text=Opponents%20argue%20that%20the%20research,taking%20of%20innocent%20human%20life.%E2%80%9D

How Octopuses Are Able to Taste by Touching

Giesen et al.Molecular Basis of Chemotactile Sensation in Octopus. Cell, October 2020.

Octopuses have often captured human interest with the ability to use their eight suction-cup covered tentacles for touch and taste. Scientists have wondered for decades how their appendages work but very few have studied what happens on a molecular level. In a new report, researchers got a glimpse into how the nervous system in an octopus’ tentacles manage these functions. They identified a novel family of sensors in the first layer of cells inside the suction cups that have adapted to react and detect molecules that do not dissolve well in water. The chemotactile receptors on these sensory cells use those molecules to help the animal figure out what it is touching and whether or not that object is prey. This allows an octopus to distinguish between a rock versus a tasty crab. The underlying mechanism is that there are two types of sensory cells in the suckers that line their tentacles: mechanosensory cells for touch and chemosensory cells for taste.  Both taste- and touch-oriented cells are critical for helping octopuses to decide when to hunt and when to retreat. It is well known that particles on land easily travel through the air before they might be sniffed by a bear or a wolf’s nostrils. However, the process of smelling or tasting is much less clear in cephalopods that live in the ocean. Some chemicals can travel far from their underwater source and thus make it possible for some creatures to catch a smell of their prey from afar. But for chemicals that don’t move through the ocean easily, a touch-taste strategy can be useful for marine animals, including octopuses. While people tend to perceive five basic tastes – sweet, bitter, sour, salty and umami (meaty) – octopuses experience the world of taste differently. Instead, scientists found the most success by stimulating octopuses to respond to what are called terpenoid molecules, a secretion that is often released by marine invertebrates that functions as a defense or warning signal. They smell these molecules and can, in a way, smell fear in their prey.

Natural Forest Regrowth May Be the Best Method to Combat Climate Change

Cook-Patton et al. Mapping carbon accumulation potential from global natural forest regrowth. Nature, September 2020.

Reforestation has been considered the leading strategy in the fight to mitigate the effects of climate change with previous studies highlighting the role it can play in capturing and storing atmospheric carbon. There are many ways to incorporate trees into our landscapes, however one of the cheapest and easiest options is to allow forests to regrow on their own if conditions can permit them to. Now, a new study has mapped the potential carbon accumulation in naturally regrown forests over the next 30 years. Researchers from 18 countries brought together more than 13,000 georeferenced measurements of carbon accumulation to generate a wall-to-wall, one-kilometer-resolution map spanning 43 countries that highlights areas with the greatest carbon returns if trees were allowed to reforest naturally. The team demonstrated that natural forest regrowth can capture up to 23 percent of global carbon dioxide (CO²) emissions from the atmosphere every year. This is on top of the carbon sequestration already provided by existing forests, which absorb around 30 percent of annual CO² emissions. The biggest advantage of natural restoration of forests is that it often requires nothing more than human inaction. Nature is constantly at work doing its duty to restore forests often unseen on the edges of fields, on abandoned pastures, and wherever forests lie degraded or former forest land is abandoned. Moreover, natural forest regrowth may promote the re-establishment of local tree species that are best equipped to survive in a given location and support the many organisms that eat them or dwell amongst their branches and roots.

However, natural regrowth may not always be the answer. For example, at sites that are highly degraded, or seed sources are far away, actively planting trees can help to start or speed recovery while helping to establish the right species mix for current and future conditions. While planting trees can sometimes be necessary it should usually be the last option since it is one of the most expensive and often least successful methods of combating climate change. It is estimated that humanity should collectively plant about a trillion trees over the next three decades to effectively fight climate change, which averages out to about a thousand new trees planted in the ground every second and assumes that every tree survives and grows in a healthy manner. Once the cost of nurseries, soil preparation, seeding, and thinning are accounted for, it would easily cost hundreds of billions of dollars. If natural forest growth is cheaper and better then why not work to protect the existing trees and let forests to grow on their own?

Li et al. Innate connectivity patterns drive the development of the visual word form area. Scientific Reports, October 2020

A new study suggests that humans are born with a part of the brain that is prewired to be receptive to seeing words and letters. Researchers analyzed brain fMRI scans of 40 newborns and found that the “visual word form area” (VWFA) was already connected to the language network of the brain, which is akin to the scans of 40 adults. These findings are quite surprising considering some researchers had hypothesized that the pre-reading VWFA starts out like any other part of the visual cortex that are sensitive to seeing faces, scenes, or other objects and only becomes selective to words and letters as children learn to read or at least as they learn language. However, a new study shows that even at birth, the VWFA is more functionally connected to the language network of the brain than it is to other areas. It is likely that experience with spoken and written language will strengthen connections with specific aspects of the language circuit and further differentiate this region’s function from its neighbors as a person gains literacy. The main goal of this study is to learn how the brain becomes a “reading brain” and to help understand the differences in reading behavior, which could become useful in the study of dyslexia and other developmental disorders.

“Free radicals” are a special type of atom that have been linked to many age-related diseases. They form as a result of a process called Oxidative Stress, which takes place when an oxygen molecule splits into single atoms with unpaired electrons. The nature of electrons is such that they like to be in pairs and as a result will “freely” and “radically” search throughout the body for another electron to pair with. They could almost be considered romantic if they were not so dangerous!

Their main danger comes from the damage that they cause to cells or cell membrane, proteins, and DNA. Cellular damage occurs when free radicals travel through cells and disrupt the structures of other molecules. The gradual accumulation of them, and the increased damage that builds as more and more of them collect, is what helps cause many of the aforementioned aging diseases. Our body is under constant assault from oxidative stress, and cells may function poorly or die if it occurs too frequently and without proper bodily maintenance.

Free radicals are a waste byproduct that form as a result of various chemical reactions that take place during our bodies’ normal metabolic processes. They are then “dumped,” and their eventual buildup will often harm our bodies much like how factory waste harms the environment However, they are not entirely useless; it is impossible for our bodies to turn air and food into chemical energy without a chain reaction of free radicals. Free radicals are also a critical part of the immune system, as they additionally move through our veins and can confront foreign invaders [1].

What are free radicals?

Understanding free radicals necessitates an elementary knowledge of chemistry.

Electrons orbit around atoms in levels called shells. Each shell is filled by a fixed number of electrons, and when the first shell is full then electrons will start to fill the next shell.

If there is an atom whose outer shell is not full then it may bond with another atom by using the electrons to fill its outer shell. These types of atoms are known as free radicals.

Atoms that have a full outer shell become stable, however free radicals are unstable. They are “desperate” to acquire the full number of electrons that are necessary to fill all of their shells and will therefore react quickly with other substances.

Take the example of oxygen molecules. If they split into single atoms that have unpaired electrons then they too will become unstable free radicals that seek other atoms or molecules to bond to. If this procedure continually occurs, then it will begin a process called oxidative stress.

Smoking, UV rays, air pollution, fast food, pesticides, ionizing radiation, drugs, and inflammation have all been linked to the formation of free radicals. We must be diligent when it comes to understanding how these influences can affect our bodily health, and then fight back with natural antioxidants.

Free radicals are heavily linked to aging

One of the effects of oxidative stress is that it can damage our body’s cells and thus promote many of the diseases and symptoms related to aging, such as wrinkles and gray hair. They will take electrons from other atoms in order to become more stable, a process that may cause diseases or signs of aging [2].              

In 1956, the “Free Radical Theory of Aging” was outlined as a way to understand how exactly our bodies age over time. Everybody ages, and as we age our body loses its ability to fight the effects of free radicals. Over time our bodies produce more free radicals and more oxidative stress, which increases the rate at which cells are damaged and thus can bring about degenerative processes.

Many age-related diseases such as muscular degeneration, certain cancers, atherosclerosis, cardiovascular disease, emphysema, Alzheimer’s disease, Parkinson’s disease, ulcers and all inflammatory diseases such as arthritis and lupus, and many others are linked to free radicals. Free radicals can be found in the food we eat such as fried foods, the medicines we take, the air we breathe, and the water we drink. Free radicals are also found in alcohol, tobacco smoke, pesticides, and air pollutants.

Several studies and theories have been linked to oxidative stress and the buildup of free radicals including: [3]

• Genetic degenerative diseases, such as Huntington’s disease or Parkinson’s
• Age-related changes in appearance, such as loss of skin elasticity, wrinkles, graying hair, hair loss, and changes in hair texture
• Cataracts and age-related vision decline
• Diabetes
• Cancer, which is associated with chromosomal effects and oncogene activation due to the reaction of free radicals [2]
• Central nervous system diseases, such as Alzheimer’s and various forms of dementia
• Cardiovascular diseases due to clogged arteries
• Autoimmune and inflammatory disorders, such as rheumatoid arthritis and cancer

The free radical theory of aging is comparatively new; however, several studies boost its credibility. Researchers focused on cell’s mitochondria, the “powerhouse” that process nutrients to power the entire cell. Experiments on rats, for example, showed a noteworthy increase in free radicals as the rats aged. These alterations coincided with age-related declines in their health. These experiments also showed that free radicals produced in the mitochondria harm the substances that the cells need in order to work properly. This damage causes mutations that produce more free radicals, thus accelerating the process of damage to the cell. This helps explain aging since aging quickens over time. The gradual, but increasingly rapid buildup of free radicals, offers one explanation for why even healthy bodies age and depreciate over time [2].

Antioxidants can stave off free radicals

Antioxidants, molecules that prevent other molecules from oxidizing and thus undergoing oxidative stress, can help to avert the harmful effects of free radicals. They can also decrease or even nullify the effects of free radicals, as they can provide an electron to free radicals and thereby reduce their reactivity. The uniqueness of antioxidants is that they can donate an electron without becoming reactive free radicals themselves.

There is no single antioxidant that can combat the effects of every free radical. Free radicals have different effects in different areas of the body, and every antioxidant performs differently due to its chemical properties. Antioxidants such as vitamins C and E, beta-carotene, glutathione, and plant estrogens called phytoestrogens all scavenge the body and help remove free radicals. Honey can also function similar to antioxidants by removing free radicals. Additionally, selenium, a trace metal that is required for proper function of one of the body’s antioxidant enzyme systems, is sometimes included in this category. The body cannot manufacture these micronutrients so they must be supplied in the diet.

Foods that are rich in antioxidants include citrus fruits such as oranges and limes, berries, and many other fruits that are rich in vitamin C. Carrots are known for their high beta-carotene content, while the soy in soybeans, and some meat substitutes, are high in phytoestrogens. Apricots, spinach, mangoes, pumpkins, broccoli, and eggplants are all also helpful, along with a plethora of other fruits and vegetables [4].

More research needed

A 2010 study on antioxidant supplementation for the prevention of prostate cancer found no benefits. Furthermore, a 2012 study found that antioxidants did not lower the risk of lung cancer. On the other hand, the study found that people who were already at a heightened risk of cancer, such as smokers, actually had a slightly elevated risk of cancer due to antioxidants.

Some investigators have found that supplementation with antioxidants is injurious when people take more than the recommended daily allowance (RDA). A recent analysis found that high doses of beta-carotene, or vitamin E, appreciably increased the risk of dying. One study found that long-term use of beta-carotene could reasonably reduce the risk of age-related mental problems [4]. But perhaps one of the most important discoveries is that antioxidants are unable to “cure” the effects of free radicals completely [5].  

Additionally, we do not yet fully understand why free radicals form in the first place. They may result as an early sign of cells fighting diseases, or that free radical formation is simply a natural expectation that comes with aging. It is not possible to understand them completely without more conclusive research, which should be encouraged considering the significant impacts that free radicals can have upon our bodies.

References

1. https://www.rice.edu/~jenky/sports/antiox.html
2. https://www.medicalnewstoday.com/articles/318652#How-do-free-radicals-damage-the-body
3. http://www.mytruehealth.info/mytruehealth_antioxidants_freeradicals.html
4. https://www.medicalnewstoday.com/articles/318652#Antioxidants-and-free-radicals
5. https://www.medicalnewstoday.com/articles/318652#What-we-do-not-know

Cancer is a prevalent disease among humans and animals, affecting millions of lives across the globe. It can be caused in a variety of ways and can affect virtually every part of our bodies, ranging from skin cancer caused by prolonged exposure to the sun’s harmful UV rays to lung cancer that results from carcinogenic substances smokers inhale. However, plants do not die of cancer despite sometimes being exposed to the sun for over a thousand years – and they do not use any sunscreens!

Humans and animals who live to a certain age are very likely to get cancer one day. We see this situation mostly in our pets which have been specially bred and protected from predators and diseases. Cancer has become part of our lives and remains a top world health priority. The probability of prostate cancer is roughly 80% in 80-year-olds, 90% in 90-year-olds, and 100% in 100-year-olds. However, these statistics yet again do not apply to trees.

What is cancer?

Cancer is a disease caused by the uncontrolled growth of cells that have become abnormal in a part of the body. These abnormal cells are not foreign invaders that have entered our bodies from outside but are instead our own cells. However, in time, various factors such as radiation, viruses, and chemical substances that they are exposed to cause the accumulation of errors, or mutations, in the genetic codes of cells. Some of them then acquire very different characteristics and become alien to their own body.

With old age, errors arise in the genetic code in an increased rate when our cells divide by copying their own DNA. External factors, such as “free radicals” and various radiations that affect our DNA, play a role in these errors. For young people, when there are too many errors in a cell’s genome, a process called “apoptosis” takes place after which faulty cells die before they can multiply in a potentially cancerous manner and forming a tumor. However, sometimes these accumulated errors cause the cell’s growth process to become stuck in the “on” position, and the cell begins to grow and divide continuously. Cells that emerge with out-of-control divisions ignore the commands coming from the healthy cells of the body, continue to grow and reproduce according to the erroneous commands from the cell’s disrupted genome. This situation lasts until death.

What is a tumor?

Cell growths that result from defective genome proliferation will eventually form a mass called a tumor. Some cells grow very slowly and stop at a certain size after a while and do not spread anymore and are called benign tumors. Masses formed by fast-growing, defective (cancerous) cells are known as malignant tumors. Cells that detach from malignant tumors and grow rapidly can attach to another organ where they will begin to grow again when they enter the bloodstream. The process by which cancerous cells start from a tumor and spread all over the body to different organs is known as metastasis.

Why does this process not happen in plants?

One of the most destructive features of cancer when it enters metastasis is the mobility of malignant cells to varying degrees according to their type. Blood vessels, i.e. the transportation pathways of the circulatory system, act like a highway for cancer cells. As the blood vessels surround the entire body, a single cancerous cell can travel to and settle almost anywhere in the body, from the toes to the head.

Plant cells have a vital feature that is different from human and animal cells. In plants, cells do not change their locations because their cells are surrounded by a very rigid, strong, and impenetrable wall outside of normal plasma membranes. Cell walls are made of cellulose, which constitutes the main substance of plants, and form the wooden structures that ensure the plants stand upright and harden while at the same time locking each cell in place and preventing it from migrating within the organism.

Another important difference that is unique to plants is that they do not have blood circulation in which cells are carried; they have a circulatory system in which only water and food are carried. This system is often used to pump water from the roots to the leaves and to transport organic products such as sugar, which is a product of photosynthesis, from the leaves down. Therefore, there are no blood cells or immune system cells in these carrier channels, which are known as wood and roe tubes (xylem and phloem), in plants.

In addition, animal cells are specifically employed in tissues and organs such as muscle, bone, liver, and skin during embryonic development. Thus, when they divide only new cells of the same type are created. Tumors that occur in animal tissues can metastasize into different tissues and disrupt different organs. We can think of animal and human biology as a very complex system in which each cell, tissue, and organ has a task and purpose. In such a system, all elements work in cooperation for the continuation of life. This system is of a kind of irreducible complexity. A human being cannot live without organs like brain, heart, or lungs, while plants, on the other hand, have fewer simpler internal structures which are not as vital. When plant cells divide, they retain their ability to form new cells of any type. This is called totipotency.

In plants, every necessary structure can be recreated from the few tissues they have. For this reason, a gardener can grow new plants from the roots, branches, or leaf parts of a plant.

Plants are equipped with very powerful antioxidants to protect them from the sun’s harmful rays and mutations that may be caused by radiation. Therefore, tumors can develop only due to bacteria, viruses, fungi, parasites, and insects. For example, in a situation that we can call “information confusion” that occurs when Agrobacterium Tumefaciens bacteria insert some of its DNA into the plant’s DNA, an anomaly occurs in the plant’s genome. Cells that go through a rapid growth process and form tumors are not normally classified as cancer, since they simply remain in that area and cannot be transported elsewhere. Since the tumors cannot spread to the whole plant, they may cause only minor distress at most in a specific area rather than a fatal disease such as cancer. Just as the plant continues to grow around a rock that it encounters, it grows around the tumor as well. The tumor can continue to grow for years, but does not spread to the rest of the plant, meaning there is no metastasis.

In summary, plants can also be cancerous, but a cancerous tumor is not a deadly threat to a plant, as its cells are immobile and do not have vital and complex organs like humans and animals. Thanks to the cellulose walls gifted to the them, plants continue their role in the ecosystem by continuing to grow with healthy cells around the tumor as if nothing had happened.

References

• Luis Villazon. “Can a plant die of cancer?” www.sciencefocus.com/nature/can-a-plant-die-of-cancer
• Sam Westreich. “Do Plants Get Cancer?” medium.com/@westwise/do-plants-get-cancer-60eb435c6d1a
• Stuart Thompson. “Plants couldn’t run away from Chernobyl—but that’s what saved them. Why plants don’t get cancer.” www.popsci.com/chernobyl-plants-radiation-cancer

Nose cells as the key COVID-19 entry point

Sungnak et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature Medicine, April 2020.

The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Detection of the virus was first reported in Wuhan, China and has since spread worldwide and emerged as a global pandemic. COVID-19 primarily affects the lungs and airways and has a wide range of symptoms including fever, coughing, and sore throat. One of the scariest aspects of the virus is that some people may not manifest symptoms but can still carry and spread it. In severe cases, the virus causes pneumonia that can ultimately lead to death. Studies suggest that the virus is thought to be spread through respiratory droplets produced when an infected person coughs or sneezes and appears to be easily transmitted within affected areas. COVID-19 has spread to more than 184 countries and claimed more than 190,000 lives so far. One of the major questions scientists around the world are trying to understand is how the virus spreads, how we can prevent transmission, and how we can develop an effective vaccine. To discover the target cells involved in COVID-19 transmission, scientists analyzed the gene expression profiles of thousands of cells from 20 different human tissues including the lung, nasal cavity, eye, gut, heart, kidney, and liver. They specifically looked for individual cell types that expressed both of two key COVID-19 entry proteins – the receptor protein ACE2 and the TMPRSS2 protease. These analyses revealed that mucus-producing goblet cells and ciliated cells on the inner lining of the nose have the highest level of COVID-19 virus proteins of all cells in the airways. While there are many external and internal factors that contribute to the virus’ transmissibility, these findings are consistent with the rapid infection rates of the virus. The location of these cells on the surface of the inside of the nose makes them highly accessible to the virus and also may assist with transmission to other people. Interestingly, ACE2 and TMPRSS2 were also found in cells in the cornea of the eye and in the lining of the intestine. This suggests another possible route of infection via the eye and tear ducts, and also revealed a potential for fecal-oral transmission. These findings have important implications for understanding viral transmissibility and could have critical translational implications. For example, given that nasal carriage is likely to be a key feature of transmission, drugs and vaccines administered intra-nasally could be highly effective in limiting the spread of the virus.

Neutrinos Could Explain Why the Universe Has So Much More Matter Than Antimatter

The T2K Collaboration. Constraint on the matter–antimatter symmetry-violating phase in neutrino oscillations. Nature, April 2020

The current laws of physics propose that 13.8 billion years ago, at the time of the Big Bang, every particle of matter had been created with a counterpart called antimatter. Antimatter is precisely the same as matter but with an opposite physical property such as an electrical charge. The great mystery for physicists is why there is so much more matter than antimatter in the universe. If there had been equal quantities in the beginning then each particle would have wiped each other out in a blaze of energy and left the universe full of just photons and dark matter. To understand the mystery behind this asymmetry, scientists have utilized an experiment known as “T2K.” T2K is a collaboration between 500 international scientists that employs a proton accelerator in Japan that generates beams of subatomic particles called muon neutrinos and antineutrinos which then travel 295 km to the gigantic Super-Kamiokande detector, located in a tank filled with 50,000 tons of water under a mountain in Kamioka on Japan’s west coast. During this trip, the muon neutrinos and antineutrinos change in flight to electron neutrinos and antineutrinos, demonstrating the phenomenon of neutrino oscillations. The team observed for the first time that there is a significant difference between neutrino and antineutrino oscillations. Neutrinos were found to turn into electron neutrinos at a much higher rate than their antineutrino counterparts and, as a result, would propagate regular matter at a higher rate than antimatter. These results show that although matter and antimatter look so similar to each other, they can behave completely different. Previously, scientists have found some differences in behavior between matter and antimatter versions of other subatomic particles called quarks, but the differences observed did not seem to be large enough to account for the dominance of matter in the universe. This new data indicates that subatomic particle neutrinos might be the very reason the universe is dominated by matter. While the scientific community is very excited about these results, most experts suggest collecting a lot more data in order to get the confidence level of their results up over the current ratio of 95%.

Humans Tend To Go With Our “Gut Feelings” Over Evidence-based Decisions

Konovalov& Krajbich. Mouse tracking reveals structure knowledge in the absence of model-based choice. Nature Communications, April 2020.

A new study showed that when faced with a decision, humans prefer to follow their “gut feeling” or habits instead of taking all facts into account. In the study, participants played a simple computer game in which identifying patterns could make them more money. While following the patterns led to success most of the time, there was still a 10-40% chance that it would not give the best outcome. The researchers observed that 56 of the 57 participants were able to identify the pattern to make the decision that gave them the highest chance of success. However, only about 20% of players consistently went with that choice after it failed them. The other 80% of players diverged and made choices based upon their gut feelings. The researchers suggest that participants decided to go with their gut feelings when making in-game decisions because choosing the best pattern only led to a slightly higher chance of success. This study highlights how decision-making works in real life. People can learn what choices lead to the best outcomes; but putting that knowledge into practice can often be difficult as it likely takes a lot of mental and sometimes physical energy to always make decisions based upon your knowledge of your current environment. Moreover, the rewards of following the best strategy aren’t always obvious in real life. Following a familiar strategy may increase your success by only a small percentage. In our decision making, there is always the dilemma – what we should do from a statistical perspective versus what worked out well recently, typically in an anecdotal manner.

Our brains consist of many different types of cells, including astrocytes, microglia, and neurons. These are the cells that people are indirectly referring to when you hear someone say that hitting your head can cause permanent damage even though the initial impact was a minor one. They are the primary cells that are responsible for signaling functions, and one can see this in their shape because they resemble an electric cord. The dendrites receive signals, process them in cell bodies, and send an output signal via the axons and synaptic terminals (Figure 1). These cells cannot multiply, and our heads never get larger, so it begs the following question: how do we continue to learn and store information? The answer is long-term potentiation (LTP).

LTP is when synaptic connections between neurons become stronger with frequent activation. Neuronal activation is an electrical signal called an action potential that emerges due to a change in ion locations resulting in electrical potential that generates a nerve impulse (Figure 2). When the same neurons keep getting activated, again and again, a shortcut is created. We have two crucial receptors that play a role in this mechanism: AMPA and NMDA. AMPA is activated first because a Mg2+ ion blocks NMDA. As AMPA gets activated, the neuron becomes depolarized (due to the previously mentioned electrical changes). Now, the neuron is more positive overall, which will push the Mg2+ ion out of the channel, which is called the Law of Attraction in physics (i.e., opposites attract). With the Mg2+ ion removed, calcium ions can move freely through the NMDA receptor, and this influx of calcium initiates cellular mechanisms that cause more AMPA channels to be produced and placed on the synapse of the neuron, making the pathway activated quicker and quicker (Figure 3). These pathways become a default, and this is called long-term potentiation. The opposite of long-term potentiation is long-term depression, a decrease in synaptic strength, so if “you don’t use it, you lose it.”

Long-term potentiation is thought to be a way in which the brain changes in response to experience, and thus may be an underlying mechanism for learning, retaining memory, and even overall physical health. With long-term potentiation our default pathways are formed; so if we train ourselves to be anxious and stressed individuals, then we will be at an increased risk for developing hypertension, heart disease, cancer, and almost any other physical illness. We often forget that stress itself is a risk factor along with other lifestyle choices such as diet and regular physical activity. An interesting article, “The Science of Happiness: Why Complaining is Literally Killing You,” delves into this point of view:

“When your brain is firing off these synapses of anger, you’re weakening your immune system; you’re raising your blood pressure, increasing your risk of heart disease, obesity and diabetes, and a plethora of other negative ailments… This is why it is so important to spend time with people who lift you up. Want to be happy? Surround yourself with happy people who rewire your brain towards love.” (http://www.curiousapes.com/the-science-of-happiness-why-complaining-is-literally-killing-you/)

Long-term potentiation is also the basis of cognitive-behavioral therapy, which is a form of psychotherapy treatment that is goal-oriented and takes a practical approach to problem-solving. Cognitive-behavioral therapy recognizes the underlying mechanism of long-term potentiation: neurons that fire together wire together and puts it to good use by trying to change default patterns of thinking and behavior. By changing these default patterns, the result changes how we feel. For example, a common practice in cognitive-behavioral therapy is to keep a daily gratitude journal. The therapist may ask their client to write three things they are grateful for each morning and each night, whether it be something as simple as having water to drink or a significant life event. Forcing yourself to make these connections continuously, and being in a default repetitive state of gratitude, has been scientifically proven to decrease rates of depression and other mental illnesses.

Another perspective we can approach LTP from is from the lens of faith and prayer since prayer has an element of repetition in it. In his book, Fethullah Gülen: A Life of Hizmet, Jon Pahl states that “Peacebuilders pray, and prayer is a nonviolent practice. Even more: prayer has power. The power of prayer is neither political nor miraculous. Personally, prayer builds confidence. The repetition of prayer comforts a troubled mind with the solace of the familiar. Culturally, prayer builds trust. Communing with God and others can make any challenge seem surmountable. Socially, prayer builds movements.”

Yes, if we could rewire our brains towards love and peace with each prayer, we could find comfort and peace, and build bridges with those around us. In 2019 alone, the Islamic scholar Fethullah Gülen Hodjaefendi, mentioned the word “neurons” in his weekly sermons nine times, a fascinating statistic for a scholar who is neither a neuroscientist nor psychiatrist. Some excerpts from these sermons include:

“[when recited and listened to a couple times during the day and in the Tarawih Prayer] the Qur’an will establish itself better in our minds; our neurons will open their doors like the doors of a castle to the Qur’an and say ‘enter.’ Therefore, who knows how many times a day, a reunion will be established with the Qur’an.” (Ramadan: The Month of Mercy, Hope and Abundance on May 10, 2019)

“Bediuzzaman says: ‘Even if we had four hands instead of two, they would not be sufficient to do things we need to do.’ … In this case, we must send orders to the millions of neurons in our brain at the same to dedicate them all to the same task. … God opens you a window to exit. (Means for Serenity and Talk of the Beloved on April 4, 2019)

“[‘The entire universe is a great book of God; the meaning of each letter is nothing but God.’] Just as you … use all of your neurons to see the endless possibility of bounties, lined along like a gallery as if He is to say, ‘see and think as you walk this gallery.’ (Sorrow, the Spiritual Heart and Tongue on March 29, 2019)

To return to the biological aspect of neurons, one key component that is also valuable to synthesize all the information we have just covered, and that is the concept of “mirror neurons.” When we observe another person these mirror neurons start to fire and a kind of virtual reality simulation is formed in our minds, contributing to the construction of a theory of our intentions. For example, when someone smiles, you want to smile back; when someone gets a paper cut, you feel their pain; or when someone cries, you cannot help but cry as well. These are all phenomena explained by mirror neurons. Mirror neurons explain empathy on a biological level and are present even in animals.

From a multi-disciplined approach, including biological, psychosocial, and spiritual perspectives, one lesson becomes clear: we have the free will and responsibility to carve our default pathways. To make sure these default pathways are filled with love, peace, serenity, alongside discipline, patience, and resilience is paramount to our personal and collective health. By defining our own neural pathways, we will also be building our community’s networks since neurons mirror each other.

Washing our hands has become one major way to protect ourselves from Covid-19. However, ablutions have always had a central place in the practices and beliefs of many religious traditions. Christians perform baptism with water, in amounts varying from small sprinkles to larger vessels, to bring about purification, cleanliness, revival, and rebirth. Jesus’ washing the feet of his disciples as narrated in the Gospel makes the washing of feet an important practice in Christianity to promote cleanliness and is still carried out to this day. The Jewish tradition also has many instances of ablution where water is specifically used to promote cleanliness, including washing hands to reclaim or preserve purity and mikveh in which the feet or whole body is immersed in water.

The Islamic ablution, also known as “wudhu,” contains 24 washing movements to be carried out several times a day for the five daily prayers. If performed for all five prayers, it would consist of about 120 repeated actions as Muslims washed parts of their body.

A lover must undertake the required preparation to cleanse and beautify oneself before meeting with their Beloved. Likewise, a believer is required to wash specified parts of their body to stand before God in supplication, as instructed in Chapter Maidah of the Qur’an, verse 6: “O believers, when you stand for prayer, wash your faces, and your hands up to the elbows, and wipe your heads, and wash your feet up to the ankles. If you are unclean, bathe and purify your bodies fully. But if you are ill or in the middle of travelling or … you cannot find water, then take wholesome dust and wipe your faces and hands with that. For God does not wish to burden you, rather He desires to purify you and to complete His blessing and favor upon you so that, perhaps, you may be grateful” [5:6].

The spiritual cleansing that the act of wudhu provides is highlighted by the Prophet Muhammad (pbuh) in numerous hadiths, or prophetic sayings, which has been collected under The Book of Purification. While water literally cleans the face and limbs, with every pure intention to do wudhu, the water droplets that meet the body also wash away the minor sins that were committed by the hands, mouth, face, ears, and feet. The famous hadith that “cleanliness is half of faith” [Sahih Muslim, 223] can be interpreted as applying primarily to doing wudhu in one translation [Wudhu: Fiqh, Rules, Purification and Blessings, Qadri]. Therefore, to perfect the faith, to be cleansed of our mistakes continuously, God has given us a simple mechanism through which to be purified and recalibrated countless times in a day.

Many of us perform this pattern of washing with little thought. It has become a routine that we seldom consider a medical protection that we apply to our body. Besides its effects on the soul, washing also has wonderful effects on the body. Over fourteen hundred years ago, the Prophet (pbuh) advised ablution before going to bed. Interestingly, yoga experts in recent years have also started to encourage the washing of the legs, hands, arms, eyes, and the mouth before sleep with cool water for a deeper undisturbed sleep. This is not surprising considering the relief that comes with the touch of water on a busy day.

Three of our principal systems benefit from wudhu; the circulatory system, the immune system, and the electrostatic balance of the body. In this way, the health benefits from the ritual of washing are threefold…

Circulatory system

The circulatory system is a magnificent circuit of blood vessels between the heart and the tissues that make up every other system of the body. The systemic circulatory system circulates oxygenated blood from the heart to the tissues around the body and back to the heart, whilst the pulmonary circulatory system transports deoxygenated blood to the lungs for detoxification and returns clean blood to the heart. The correct functioning of the blood vessels, which act as wires that connect our major organs, are essential to the efficiency of this circuit. These vessels divide into thinner branches called arterioles which in turn split into smaller capillaries which surround the cells of the body. The vascular resistance generated by blood vessels is overcome by the blood pressure generated by the heart to enable blood flow. Over time (due to ageing, or a diet high in fat), our blood vessels often harden and become constricted meaning that the heart has to work harder to overcome increased vascular resistance to maintain steady blood flow. The vessels in the limbs are the most peripheral to the heart and thus the most vulnerable to the process of hardening and narrowing over a long period.

The application of water in our daily routine “exercises” these blood vessels by alternately contracting and dilating them. Water can act as an agent of temperature gradients, thereby affecting the thermoregulatory response of the cutaneous circulation. When hot, water ensures that vessels in the limbs dilate, and when cold, that they contract. In this way, water ensures the flexibility of vessels distant from the heart, forcing nutrients deposited in tissues as a result of poor circulation back into the bloodstream through a temperature gradient.

Lymphatic system

The lymphatic system, on the other hand, is probably not the first to come to mind when we think of the body’s organ systems. Yet without this quietly working system our cardiovascular system would collapse and our immune system would be impaired. Our lymphatic vessels transport “leaked” blood fluids into our capillaries to prevent the accumulation of fluid in the interstitial spaces and eventual tissue damage. The vessels of the lymphatic system are much thinner than those of the cardiovascular system, ensuring the circulation of white blood cells which have an essential role in protecting the body against invaders and resisting disease. It is this fluid that we see oozing out when we have a cut or wound.

The optimal functioning of this system and its thin vessels, like those of the circulatory system, can be said to be closely linked with the effect of washing. The phagocytes and lymphocytes, which make up the immune system are housed by our lymphoid tissues and organs, are supported by the act of wudhu. The nasopharyngeal region behind the nose leads to the tonsils, which are small masses of lymphoid tissue that trap and remove pathogens that are entering the throat. Washing the mouth and nose three times with every wudhu therefore helps to remove the bacteria that builds up in the region of the body most exposed to the external environment. Moreover, the act of washing both sides of the neck during wudhu stimulates our cervical lymph nodes – a specialized mass of tissue which houses lymphocytes and particularly helps to protect the body by removing bacteria and tumor cells from lymphatic circulation. Our lymphocytes are arguably the most important component of our immune system, patrolling every point of the body many times a day and destroying cancer cells and pathogens along the way. Considering that the act of wudhu enhances the filtration effect of our lymphoid circulation, one can see the blessings that come with the divine command to “wash…and purify your bodies fully….”

Electrostatic balance

Our physiology is also closely related to the electrostatic balance of the body. While many psychosomatic diseases result from electrostatic imbalance, the most pronounced effect of static electricity is exerted on the subcutaneous muscles located under the skin, mitigating their function and inducing the onset of wrinkles which often start in the face. Maintaining the regular habit of washing the skin – particularly the face which is most frequently exposed to ultraviolet radiation – protects the surface and internal layer of our skin cells by constantly dampening the skin surface with clean water. It is a much simpler alternative to spending hundreds and hundreds of dollars on expensive skin care and makeup products to maintain a healthy complexion.

In regards to how wudhu can benefit our electrostatic balance, the part of the verse which sheds light to tayammum, “if you cannot find water, then take wholesome dust and wipe your faces and hands with that” highlights that the water substitute for wudhu significantly reduces static electricity, like water. This is why when wudhu is performed calmly with care, it often leaves one feeling refreshed and discharged.

The Quran is a grand source containing many prescriptions for good health. While every civilized person may wash their face and hands throughout the day, wudhu ensures that cleanliness and a sense of well-being is sustained by virtue of its association with worship. The worth and significance of wudhu is not limited to the medical benefits discussed here. However, for anyone else wondering why taking a pause on a busy day with wudhu feels so rejuvenating, I hope this humble article sheds some light to a grand prescription from among the many medicines revealed in the Qur’an.

Andersen KG et al. The proximal origin of SARS-CoV-2. Nature Medicine, March 2020.

Cases of Covid-19 first emerged in December 2019, when a mysterious illness was reported in in the city of Wuhan, China. The cause of the disease was soon confirmed as a new kind of coronavirus, and the infection has since caused a large-scale epidemic and spread to more than 70 other countries. Coronaviruses are a large family of viruses that are related to a broad spectrum of illnesses, the first of which was the 2003 Severe Acute Respiratory Syndrome (SARS) epidemic in China. A second outbreak of severe illnesses began in 2012 in Saudi Arabia with the Middle East Respiratory Syndrome (MERS). On December 31 of 2019, Chinese authorities alerted the World Health Organization of an outbreak of a novel strain of coronavirus named SARS-CoV-2 causing severe illness. As of February 20, 2020, nearly 167,500 Covid-19 cases have been reported, though many milder cases have likely gone undiagnosed. More than 6,600 people have already died as a result of contracting this virus – and the numbers will be much higher when you will be reading this article. Chinese scientists sequenced the genome of SARS-CoV-2 very shortly after the epidemic began and made the data available worldwide. The analyses of genomic sequence data have shown that Chinese authorities rapidly detected the epidemic and that the number of Covid-19 cases have been increasing because of human to human transmission after a single introduction into the human population.

Recently, a group of scientists used this sequencing data to explore the origins of SARS-CoV-2 and how it has become the version that it is now. The scientists specifically focused on the genetic codes for spike proteins, the mechanical framework on the outside of the virus that it uses to grab and penetrate the outer walls of human and animal cells. There are 2 major parts of the spike proteins: the receptor-binding domain (RBD), a molecular hook that grips onto host cells, and the cleavage site, a molecular can opener that allows the virus to crack open and enter host cells. The scientists found that the RBD portion of the SARS-CoV-2 spike proteins mutated to effectively target a molecular feature on the outside of human cells called ACE2, a receptor normally involved in regulating blood pressure. The SARS-CoV-2 spike protein was exceptionally effective at binding to human cells, and the scientists concluded this could only be a product after a natural selection process and not the product of human-designed genetic engineering. This evidence was further strengthened by data on SARS-CoV-2’s backbone molecular structure. If someone were to engineer a new coronavirus as a pathogen, they would have constructed it from the backbone of a virus known to cause illness. But the scientists found that the SARS-CoV-2 backbone differed substantially from those of already known coronaviruses and mostly resembled related viruses found in bats and pangolins. These two features of the virus, the mutations in the RBD portion of the spike protein and its distinct backbone, basically ruled out laboratory manipulation as a potential origin for SARS-CoV-2. Based on their genomic sequencing analysis, scientists came up with two possible scenarios as the most likely origins for SARS-CoV-2.

In the first scenario, the current pathogenic state of SARS-CoV-2 has emerged naturally in non-human hosts such as bats or pangolins and then jumped to humans. Coronaviruses are well known to undergo genetic recombination. In fact, this is exactly how previous coronavirus outbreaks have emerged, with humans contracting the virus after direct exposure to civets (SARS) and camels (MERS). The researchers proposed horseshoe bats as the most likely reservoir for SARS-CoV-2 as it is very similar to a bat coronavirus. There are no documented cases of direct bat-human transmission so far, suggesting that an intermediate host was likely involved between bats and humans.

In this particular scenario, both of the distinctive features of SARS-CoV-2’s spike protein and the cleavage site would have mutated to their current pathogenic state prior to entering humans. In this case, the current epidemic would probably have emerged rapidly as soon as humans were infected, as the virus would have already equipped with the features that make it pathogenic and able to spread between people.

In the second proposed scenario, a non-pathogenic version of the virus jumped from an animal host into humans and after a mutation process it has acquired its current pathogenic state within the human population. For instance, some coronaviruses from pangolins, armadillo-like mammals found in Asia and Africa, have a spike protein very similar to that of SARS-CoV-2. A coronavirus from a pangolin could possibly have been transmitted to a human, either directly or through an intermediary host such as civets or ferrets.

In this scenario, only the cleavage site could have mutated within a human host, possibly via limited undetected circulation in the human population for months or maybe years prior to the beginning of the epidemic. The researchers found that the SARS-CoV-2 cleavage sites have similarities that resemble strains of bird flu that can transmit easily between people. In the case of SARS-CoV-2, such a virulent cleavage site could have been formed in human cells and soon the current epidemic got initiated, as the coronavirus would possibly have become far more capable of spreading between people.

At this point, it is almost impossible to know for sure which of the scenarios is most likely. If the SARS-CoV-2 entered humans in its current pathogenic form from an animal source, it raises the probability of future outbreaks, as the illness-causing strain of the virus could still be circulating in those animal populations and might come back to humans again. It is still noteworthy that a non-pathogenic coronavirus entering the human population and then acquiring properties similar to SARS-CoV-2, the second scenario, is less likely than the first scenario.

In conclusion, this study brings an evidence-based view to the baseless rumors and conspiracy theories that the SARS-CoV-2 was deliberately manufactured in a lab and concludes that the virus has emerged after a natural process that took place in multiple hosts over time. These genetic findings are also consistent with how SARS-CoV2 is currently behaving. The virus has a low fatality rate (1% to 3.4%) and does not seem to act like a bioweapon compared to pathogens such as anthrax or Ebola. Given the previous coronavirus epidemics and the persistence of the culture of eating exotic mammals in China and other parts of the world, the current COVID19 epidemic is unfortunately not a big surprise for scientists and experts. We have to take necessary measures to be more prepared for such outbreaks that may take place in future.

Diabetes is one of the most serious public health risks today. The United Nations declared diabetes as a global threat in 2007 in order to highlight just how widespread and destructive diabetes had become.

Diabetes is one of the oldest known diseases, and was even mentioned in the ancient Egyptian, Indian, and Chinese texts. Ancient Egyptian texts defined diabetics as “… so thirsty that if they drank all the water of the Nile, their thirst would still not be quenched.” The ancient Indian and Chinese texts mention insects and flies swarming over the urine discharged by the diabetics.

Ancient scientists Al-Razi and Ibn Sina (Avicenna) made important findings about diabetes. Al-Razi linked diabetes with obesity and nutrition habits. Ibn Sina specified that no tissues or organs could survive diabetes, which additionally caused sexual dysfunctions and gangrenes.

There are two main problems that emerge in relation to diabetes:

• Type 1: Lack of adequate secretion of the insulin hormones from the pancreas
• Type 2: Non-functional and insulin-resistant tissues, regardless of adequate insulin secretion

These two types do not coexist in one patient. The first occurs mostly among children or young people. The second occurs mostly among the elderly who largely contract diabetes due to obesity. Diabetes can be detected by a surge of sugar in the blood and urine. If blood sugar exceeds a certain limit then sugar will appear in urine.

Diabetes reveals itself by a surge of sugar in the blood and the urine. It not only impairs the sugar balance of the body, but also disrupts the fat and protein metabolism. Cells fail to absorb sugar, fats, and amino acids, which in turn increases sugar, fat, and amino acid levels in the bloodstream. It can plainly be said that diabetes complications originate from an increase in fat levels, not sugar levels, in the blood. Additionally, diabetic disorders in fat metabolism cause the lethal appearance of acid levels in the blood (acidosis) and vascular stiffness (arteriosclerosis). Decrease in protein-synthesis ability among patients with long-term diabetes leads to depletion of tissues and multiple cellular dysfunctions. Consequently, diabetes originating from insulin deficiency disrupts the fat and protein metabolism along with the sugar metabolism.

The pancreatic gland is where insulin is released in our body. The surgical removal of this gland in experimental animals showed that fat levels in their bloodstreams increased faster than sugar levels. In diabetics, fat around the abdomen and hips oozes into the bloodstream, thus leading to an increase in neutral fat (triglyceride) and cholesterol levels in the blood along with an accumulation of fat in the liver.

If fats remain in the bloodstream after nutrition, then they begin to adhere to vein walls which can cause clogging and stiffness in blood vessels. That is why it is crucial to transfer fat from the bloodstream to fat storage around the abdomen and hips by means of sugar and insulin. The storage fat is called neutral oil, or triglyceride. A triglyceride molecule contains three units of oil and one unit of sugar. Therefore, almost 25% of the fat storage is sugar. Without sugar supply from bloodstream, as in the case of diabetes, the cells which by default store fat are unable to do so. Diabetes, as a serious disorder, even reverses this mechanism: fats start moving from the storage to the bloodstream, not from the bloodstream to the storage. This causes the surge of all fats including the triglycerides, cholesterol and phospholipids, and this is when the body becomes even more prone to disease.

Obesity or excessively fat-based (steatopygic) diet is one of the main causes of diabetes. People are already overweight before the disorder strikes. However, if they do not receive treatment after contracting diabetes, the diabetics start losing weight quickly and more than they should. This happens because relatively harmless fats in storage start to dissolve into the bloodstream.

The entity called metabolic acidosis, which can cause coma and death in diabetics, actually originates from the surge of fat products in the blood and the liver, not from the surge in blood sugar. In diabetics, when the cells cannot use sugar, they resort to obtaining their energy from fats. Consequently, stored fats start to dissolve and ooze into the bloodstream. Fats traveling to the liver through the bloodstream turn into acidic substances called ketone bodies (acetoacetic acid, beta hydroxy butyric acid, and acetone). These acidic substances pass from the liver to the bloodstream and are received by the cells to meet their energy needs. However, in diabetics, cells cannot convert these acidic fat products i.e. ketone bodies, into energy. Oxaloacetic acid from sugars is required for the energy production cycle called the Krebs cycle. In short, humans need sugar to burn fat. This is why it is normal for some people to feel the need to eat something sweet after a fatty meal, because they need sugar to dissolve the fats in their bloodstreams. Since the cells cannot draw sugar from the blood, they suffer from the deficiency of oxaloacetic acid to convert fats into energy. Fats and ketone bodies teem in the bloodstream and, since ketone bodies are acidic, they can cause acidity levels to surge to extremely high levels in the bloodstream which can result in a coma or even sudden death. The lethal substances here are not sugars but ketone bodies, or fat products.

The most crucial abnormality caused by diabetes is vascular stiffness (arteriosclerosis), which originates not from excess sugar but excess fat in the bloodstream. In diabetics, triglyceride, cholesterol, and phospholipid levels increase in the bloodstream due to the reasons described earlier. Fats in the bloodstream do not circulate freely; they are carried in micro-droplets called lipoprotein. The liver loads the fats onto lipoprotein “trucks” and sets them into the bloodstream to be used by the cells. However, due to insulin deficiency in diabetics, lipoproteins cannot empty their shipments of fat into fat storages. The most dangerous lipoproteins for vascular stiffness are classified as LDL (low-density lipoprotein) and HDL (high-density lipoprotein) types. HDLs are like empty trucks specially produced by the liver, which dispatches them into the bloodstream. While circulating in the bloodstream, these “trucks” collect the fat and cholesterol stuck on the vein walls like magnets and, after cleaning the inner vein walls, they return as loaded trucks back to the liver. Using the HDL “trucks,” the liver removes fat from the bloodstream. Physicians gauge the LDL and HDL levels while checking their patients for the risk of vascular stiffness. An increase or decrease in LDL rate is not good for patients, whereas high HDL rate is a positive sign.

Other causes of vascular stiffness include lack of exercise, sedentary life and work habits, smoking, alcohol consumption, obesity, overconsuming foods rich in animal fat, and high blood pressure. Vascular stiffness is one of the leading causes of cardiac dilatation (enlarged heart), cardiac insufficiency (heart failure), and heart attack. In addition to these complications, vascular stiffness may also lead to high blood pressure, cerebral hemorrhage, paralysis, kidney failure, and vascular occlusion in the brain or other organs. If not treated, almost all of these disorders result in death.

Diabetics should follow an effective treatment regime to keep their blood sugar level under control. Fasting is known to be beneficial for controlling blood sugar. If blood sugar is normal, the fats in the bloodstream will move to the storage and not damage the blood vessels. Among the elderly and the obese diabetics, any damage originating from high blood sugar does not surface immediately, and this may mislead patients. It is extremely crucial to check blood sugar in order not to fall into this error. Treatment should never be neglected. If blood sugar can be effectively reduced, it is not right to give up sugar completely in the diet. As mentioned earlier, humans need sugar for storing fats or converting fats (or ketones) into energy in the Krebs cycle.

In short, high blood fat is a more serious cause of diabetes than high blood sugar.