Tschauner O. et al. Discovery of bridgmanite, the most abundant mineral in Earth, in a shocked meteorite. Science, November 2014.

A team of scientists has identified and characterized the Earth’s most abundant mineral: “Bridgemanite” makes up about 70 percent of the Earth’s lower mantle and 38 percent of its total volume. It is made of a high-density form of magnesium iron silicate and named after 1964 Nobel laureate physicist Percy Bridgman. For decades, scientists knew of the existence of dense Bridgemanite layers in the Earth’s lower mantle (660 to 2890 km beneath the surface) through theoretical and some experimental studies. However, since the mysterious mineral never survived the trip to the surface, no one had been able to prove its existence. Conveniently, shock-compression that occurs in collisions of asteroids creates an identical hostile temperature (2100 C°) and high-pressure (240,000 times greater than sea-level) conditions to those found in deep layers of the Earth. As such, scientists decided to look at meteorites closely, particularly one that had fallen in Australia in 1879. By using a micro-focused X-ray beam in conjunction with electron microscopy, they were able to successfully detect the Bridgemanite grains for the first time. The discovery of the Bridgmanite’s crystal chemistry will have a significant impact on the future studies of chemistry and geology of the Earth’s deep mantle, and perhaps studies on the formation of the universe.

Male smokers lose Y chromosomes

Dumanski et al. Smoking is associated with mosaic loss of chromosome Y. Science, December 2014.

The Y chromosome is one of two sex-determining chromosomes in men, who have one X chromosome and one Y (women have no Y chromosomes, but two X chromosomes). During normal cell division, copies of all of the 23 chromosomes, including X and Y, are synthesized and sorted into the two new daughter cells. This complicated process sometimes goes wrong and chromosomes are lost. Cells with missing chromosomes usually die, but cells can still survive without a Y chromosome. Scientists initially thought that men lose Y chromosomes as they age and this is a part of the normal aging process. But later studies have shown that the age-dependent loss of Y chromosomes can have serious health implications, as it is linked to a shorter life span and an increased risk of dying from cancer. Even more troubling results came from a recent study that screened for associations between behavioral and lifestyle choices, and diseases. Comparison of the DNA in blood cells of over 6000 men suggested that blood cells from actively smoking men are 3-4 times more likely to be missing Y chromosomes than the nonsmokers in the control. These findings may explain why male smokers have a slightly increased risk of death from the majority of cancers than female smokers. The scientists hypothesized that the Y chromosome loss may create defective immune cells that cannot fight cancer and ultimately make the body susceptible to tumors. The study gives some good news to smokers though. Y chromosome damage by smoking is both reversible and dose-dependent, so you are always better off not smoking; it is never too late to quit.

The world’s oldest case of cancer

Lieverse AR et al. Paleopathological Description and Diagnosis of Metastatic Carcinoma in an Early Bronze Age (4588+34 Cal. BP) Forager from the Cis-Baikal Region of Eastern Siberia. PLOS ONE, December 2014.

Cancer is responsible for one in four deaths in the Western world. It is widely assumed that cancer is a disease of modern times. Since people in older eras were exposed to fewer toxins, ate only natural foods, and adapted physically active lifestyles, many people thought that no one in older civilizations would have had cancer. Yet an analysis of a 4500-year-old skeleton from a cemetery in the Cis-Baikal region of Siberia has seriously challenged this idea. Researchers estimated that the Siberian man was about 35 to 45 years old before he died from a severe lung or prostate cancer. The ancient man’s bones, from head to hip and including his upper arms and upper legs, were covered by lesions and big holes. It is almost certain that the deterioration of his bones left him immobile and eventually caused him a very agonizing death. It is also clear that those around him recognized his situation and placed him in a circular grave in the fetal position with some artifacts ,which is completely different from the rest of the burials in the cemetery. Although ancient skeletons with the scars of cancer are relatively rare, scientists suspect that cancer may have been considerably more common in ancient times than is generally predicted, especially when considering other variables such as naturally occurring carcinogens and longer life expectancies.

Where am I?

There are 46 chromosomes in your body, carrying 20-25 thousand genes. Chromosomes and the genes they contain shape the genetic memory of a human being. Genes can contain hundreds of features, and these are revealed over time. For instance, you do not have any teeth when you are a newborn, but the time when you will get your teeth is encoded into your genetic memory. Once genes receive the action command, teeth start to emerge.

There are hundreds of genes located on chromosomes, all the way from the chromosome number 1 and 2, to chromosome number 46. For example, there are around three thousand genes found on chromosome number 1. The Y chromosome, in charge of male development, only contains 125 genes. A distinct address (locus) for each gene on the chromosomes is recorded. If you ask about the address of the fibrillin gene that synthesizes me, it is 15q 21.1, i.e., 15th Avenue, Long arm street, 21st pl, Number 1.

In other words my residing address is the 1st subband of the 1st band of the 2nd region located at the long arm of chromosome number 15. We are three siblings, known as fibrillin1, fibrillin2 and fibrillin3.

We stretch and relax like an arch. We can expand and tighten like an inflated balloon and then return to our previous state. If by an error, we happen to fail to restore ourselves after inflation, the tissue’s architecture gets deformed and expanded fibers cannot regain their original shape anymore. When observed in veins, this situation is called an aneurysm. The frequency of this disease is approximately one in ten thousand, which is also called ballooning. That said, my flexing is necessary. Veins flex so that the blood pumping through them doesn’t cause any turbulence, as it would otherwise be during a vacuum occurring inside metal water pipes. Flexible sportsmen who do acrobatic moves do not compare with me. I can bend, curve, flex, relax and constrict, inflate, deflate and transform like elastic, from one shape to another, for your health and overall convenience – all because of the wondrous features granted to my nature.

What kind of a fiber am I?

I provide structural support for the fabrication of elastic fibers in the connective tissue as a protein synthesized according to the code of the fibrillin gene. In case of my failure or absence, weaknesses occur, especially in the connective tissues of organs that are rich in elastic fibers, such as the aorta, lungs, and eye balls. The iris (the colored part of the eye), pupil, and eye lens display changes in accordance with levels of light or distance of objects observed. These changes are controlled perfectly according to my work, and humans often don’t even notice this. We also help the eye lens constrict and relax. It can be understood that we are such a great blessing granted for your service. Of course, if we tried to count all the blessings we’ve been given, and never even consider, it would be impossible!

My weight is 350 kilo daltons. A Dalton is an atomic mass unit approximately equal to one hydrogen atoms’ mass, which is 1.66×10-24. I consist of 2.871 amino acids. I am formed by the sequential arrangement of 20 amino acids that exist in your body as the smallest unit of proteins. We bind each other to become 10-12 nanometers wide microfibers as the result of a process called polymerization that brings loops of a protein chain together. These microfibers are brought together with the elastin protein that provides elasticity in our body. The system that we form with elastic fibrils constantly serves the body’s blood vessels, primarily the vessels located in your eyes, heart, and many of your tissues, such as your skin and nerves.

What do I do? We fulfill commands that are requested from us in many tissues and organs, without any flaws. Scientists call us the wonderful building blocks of the body’s architecture. We can extend twice as much of our length. We are always on task: while you are breathing, when your heart is pumping blood and your stomach is digesting food, or the moment you are gazing at nature with your eyes. We are given the duty to prevent many organs from tearing, including the heart, lungs, stomach, and blood vessels. One of the places I work most frequently is the aorta, the body’s major artery. Your heart beats approximately a hundred thousand times a day. A high level of pressure develops in the arteries during the pumping process. You would suffer greatly without the help of our elastic fibers. Blood vessels would rupture, ending your life. This high pressure is tolerated only through the expansion of the vessel’s diameter without any decrease in length of the artery. This diameter regulation is designed so wondrously that blood flow remains the same; no shaking or waves are observed. This diameter control happens via the fibrillin protein located inside the vessel.

I also play a role in the vitality and tension of your skin. Skin is essentially a dense fibrous connective tissue composed of a protein called collagen. I am also one of the main elements of this connective tissue. As you age, this layer starts to dry and has lesser fibrous proteins; therefore, as fibers decrease, so does my tension, and I start to wrinkle. Elderly people do not like getting wrinkly, but this is your fate. Whatever you do, I will also age and die.

I cannot go without pressing this important issue: Staying under the sun for a long time degrades me. If done properly, sun light is useful for skin. But solar radiation damages the live tissues and organs. This radiation is an effective factor both in degradation of protein structures, and the formation of varicose veins and skin damage. It is reported in various sources that exposure to sun rays leads to alterations in the genetic material of skin. Ultraviolet rays speed up the degradation of skin. In medical language, this is called oxidation via free radicals. Please do not burn us and yourself while sunbathing. Even if you do not care for yourselves, you should still be considerate of us. If you say that sunbathing both helps, with vitamin D synthesis and reducing the risk of osteoporosis, I would like to remind you that for the vitamin D synthesis of skin, it is sufficient to expose your hands, feet and face to the sun.

How is life without me?

Though we were wisely designed, sometimes, you are tested by certain diseases in which we are not present. Absence, as they say, makes the heart grow fonder!

Life without me is unbearable. I could give a couple of examples, should you like. If I was not created, your skin would not be flexible. You wouldn’t be able to control your eye lenses. Your aorta would not be flexible and your heart, which beats thousands of times a day, would be torn under the high pressure in a short amount of time. Major problems would occur with the development of your stomach, lungs, and other organs.

I also have a significant job keeping TGF-Beta (which helps cells grow) function under control. To give you an idea of how important this is, imagine your communication system turned upside down. Now imagine how complicated are the communication systems connecting billions of people around the world, how a mess it would be when they are out of service. These are nothing when compared to the human body. There are 100 trillion cells in the human body, communicating with each other instantaneously. A cellular community that is fifteen thousand times more crowded than the earth’s population communicates via small molecules, like us. Cellular proliferation and tissue differentiation would fail if cells failed to communicate. The full spoon of food in your hand would not end in your mouth but maybe in your ear or your eyes.

If a mutation happens with the Fibrillin-1 gene, Marfan syndrome can occur. This disease, which was defined in the 1800s, is named after its discoverer. The frequency of this disease is one in five thousand. One of the major lethal consequences of Marfan syndrome is an aorta tear. This is in addition to many problems with the eyes, skeleton, and cardio-vascular systems. Many of the patients die in their 30s or 40s because of the flaws in the cardio-vascular system. Of course, death may occur at any age because of an aorta rupture. 14% of the patients with Marfan syndrome display chronic obstructive pulmonary disease (COPD), which is associated with breathing problems, because the integrity of lung tissue is compromised. Another disease I help prevent is called Ektopia lentis, in which the eye lens is displaced from its original position. Normally, I help eye functioning. When my fibers relax or constrict, depending on light, I help the eye to relax, enabling both near and far sightedness. With Ektopia lentis, anomalies on the front vestibule of the eye, a high degree of myopia, and retina damage occur.

If overproduced, I can cause another problem with the eye, called exfoliation syndrome. This is when fibrous connective tissue, like me, accumulates in the eye – it’s commonly called glaucoma, or ocular hypertension. In some people, as they age, a fibrous material like hair dandruff collects on the eye lens. This material, dislocated by movements of the iris, blocks the drainage channels that discharge the intraocular fluid. Eye pressure increases as the result of failed drainage. As you see, I am not a problem when I am synthesized normally, but can be trouble if over produced! My final request from you!

You have seen our amazing works and complicated functions. Therefore, please remember me and my friends. Please do not ignore our efforts and activities. Be grateful for the blessings provided through us, even if you can’t see them. And take care of us, please – don’t get carried away with too much tanning!

Most Christian faith groups teach that Jesus was conceived by his mother Mary while she was still a virgin. This is believed to have been accomplished without an act of sexual intercourse. This doctrine is usually called the “virgin birth,” although the term “virgin conception” would be much more accurate. Biblical references commonly cited about the virgin birth are Isaiah 7:14 and Matthew 1:23. Various polls have found that about 80% of American adults believe in the virgin birth of Jesus. This exceeds the total number of American adults who identify themselves as Christian or Muslim. The Qur’an, the direct words of God, dictated by an angel to Prophet Muhammad, has two main references to Mary’s virginal status at the conception of Jesus: 19:16 to 22 contains a birth narrative, while 21:91 confirms her virginity. Almost 100% of Muslim adults in the world believe in the virgin birth of Jesus.

The question that frequently comes up in the minds of many is the same: How did Mary conceive? There have been different ways of explaining this. For some people, the natural phenomenon of parthenogenesis provides such an explanation. Some animal species can reproduce from an unfertilized oocyte, in a process called parthenogenesis. Although this phenomenon is quite common in plants and insects, it does not appear in any creature above the level of the amphibians. No verified case of parthenogenesis has occurred in humans, and it is considered impossible for species as complex as the higher apes or humans³ An additional complexity would be that Jesus would have been female after the parthenogenetic division of an XX oocyte, since he would have lacked the Y chromosome normally contributed by a human father. Parthenogenesis is not, therefore, a logical explanation to account for the virgin birth of Jesus.

The birth of Jesus without a biological father, in fact, should be viewed as a supernatural event-a miracle, to be more accurate. It would be useful to define here what we mean by miracle. Although a miracle is a supernatural phenomenon, there is a minimal natural cause for the miracle, which is then caused to happen by God, as appropriate. Prophet Muhammad, peace and blessings be upon him, touched a small portion of food with his blessed hands; and this food became sufficient for an entire army. Likewise, he poured water from a flask onto his hands, and the water was made enough to satisfy hundreds of people. Even though God Almighty assigns a duty to natural causes-even if the influence of the natural cause is not more than 1-3%-we should accept that in miracles it may not always be possible to have a materialistic interpretation for everything. By definition, miracles are extraordinary events that God Almighty grants to His messengers to prove their prophethood and strengthen the believers’ faith. To insist on their essential rationality is to deny their existence as miracles, and hence an objection to the revelation at some level. The universe operates according to God’s fixed laws, which allow us to discover the divine laws of nature and make scientific progress. However, God has determined these laws and therefore He is not bound by them. He may sometimes annul a law or change the ordinary flow of events to allow a Prophet to perform what we call a miracle⁴

Bediuzzaman Said Nursi comments on the miracles in his magnum opus, The Words, as follows:

By relating the prophets’ spiritual and moral perfections, the Qur’an encourages people to benefit from them. By presenting their miracles, the Qur’an urges people to achieve something similar through science. It may even be said that, like spiritual and moral attainments, material attainments and wonders were first given to humanity as gifts through prophetic miracles. . . . [Miracles] comprise numerous indications of guidance. By relating these miracles, the Qur’an shows the ultimate goal of scientific and technological developments, and specifies their final aims, toward which it urges humanity⁵

So what else can we learn from the miraculous virgin birth of Jesus? Does it indicate any specific scientific discovery? In this respect, we may refer to at least one other explanation by which a virgin conception could have been occurred, turning again to the Qur’an for an answer, as there is no contradiction between the Qur’an, the Word of God, and laws of nature, which have been designed by God. In verse 3:37 “… her Lord accepted her with gracious favor and enabled to her a good growth” the word nabat is used to describe Mary’s growth, literally meaning “plant” in Arabic. Alongside the miracle of Mary’s sustenance, could this verse be encouraging us to study the plant world to observe how plants reproduce?

Many flowering plants can reproduce by self-fertilization because a single flower produces both eggs and sperm cells. Flowers contain two sets of structures that are important for fertilization. The first is an organ that contains pollen grains, each of which contains two male sperm cells. The second is an organ that contains one or more ovaries, each of which contains egg cells (oocytes) (Fig.1). At fertilization, the pollen delivers two sperm cells to the ovary, where one sperm cell fuses with the egg cell, and the fertilized egg grows to form an embryo⁶ A question naturally arises at this point. Could a human being have two different reproductive cell types (both oocyte and sperm) at the same time? The simple answer is “yes.”

In some persons, both ovarian and testicular tissues are present, either in the same or in opposite gonads⁷ About 13% of these persons are derived from more than one zygote and are known as chimeras (chi 46,XX/46,XY)⁸ Cases with normal male and normal female phenotypes have been ascertained as an incidental finding⁹ Chimeras are the result of the fusion of two zygotes to form a single embryo and they contain cells from two separate zygotes in a single organism¹⁰ The fusion of two zygotes may occur soon after fertilization, producing an individual with genetically different kinds of tissue. If the fused zygotes are of different sexes, then the individual develops both ovarian and testicular tissues¹¹ The majority of these people are best reared as females and many pregnancies with living offspring have been reported in persons reared as females;¹² in contrast, only one person has apparently fathered a child¹³ The wisdom of the Qur’an is no doubt beyond the current level of scientific development and the human mind, and what we may deduce from verse 3:37 and scientific research, in fact, is little more than mere speculation. We certainly do not mean to suggest that Mary was a hermaphrodite; the Qur’an clearly states that she was a woman (5:75). Rather, it may be possible that she could have been a woman who had been derived from the fusion of two different embryos; i.e. a chimera.

The statement in the Qur’an (3:37) may demonstrate that Mary could have been a chimera of XX/XY type, and she might have been created by the fusion of two embryos to become one. Of course, God Almighty knows best. And whatever our limited explanation may be, it is clear that Mary co-operated in the formation of Jesus’ body just as every other mother co-operates in the formation of the body of her child. In the end, whether one looks to science or not for an understanding of the deeper mysteries of life, there is consensus among the great majority of Christians and Muslims that Jesus came to earth by means of a virgin birth. And the virgin birth of Jesus was a miracle.

Notes

1. Moore KL, Persaud TVN, The Developing Human, Clinically Oriented Embryology, 7th ed. Saunders, Philadelphia, 2003, p. 16.
2. ibid.
3. ibid.
4. M.Fethullah Gulen, The Essentials of the Islamic Faith, The Light, Inc., NJ:2005, pp. 193-4.
5. Said Nursi, The Words, The Twentieth Word, The Light, Inc. NJ: 2005, p. 267.
6. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell, ed Gibbs S. 4th ed. New York: Taylor & Francis Group; 2002, pp. 1243-1246.
7. Behrman RE, Kliegman RM, Jenson HB. Nelson Textbook of Pediatrics 17th ed. Saunders, Philadelphia, 2004, p. 1945.
8. ibid.
9. Tanaka Y, Fujiwara K, Yamauchi H, Mikami Y, Kohno I. Pregnancy in a woman with a Y chromosome after removal of an ovarian dysgerminoma. Gynecol Oncol. 2000; 79: 519-521.
10. Strachan T, Read AP. Human Molecular Genetics. 3rd ed. New York: Taylor & Francis Group; 2004, p. 110.
11. ibid.
12. Haqq CM, Donahoe PK. Regulation of sexual dimorphism in mammals. Physiol Rev. 1998; 78: 1-33.
13. Krob G, Braun A, Kuhnle U. True hermaphroditism: geographical distribution, clinical findings, chromosomes and gonadal histology. Eur J Pediatr. 1994; 153: 2-10.

Who created such miraculous entities?

At present, many highly educated people and scientists maintain there should be a creator who knows and has the power to design of all these perfectly working organizations. Starting from an atom’s particles, this systemic structure consisting of atoms, molecules, macromolecules, cell organelles, cells, tissues, organs, systems, and finally a living creature exists in all ecological balances on Earth. Without seeing the impact of such a wide and large power, it is not logical to expect that all that we see in creation is the result of unconscious nature and thus conclude that everything occurred by blind happenstance.

We remain alive because millions of cells work together. Each maintains its life by being perfectly divided into units and having complex mechanisms within its structure. Each unit has unique features. When these units come together, large and unpredictable new features might occur. For example, hydrogen is flammable and oxygen is burning, but when they join together to form water, there is no fire.

A cell, which consists of electrons, protons, and neutrons, might function differently according to its location in the body. When cells are combined with each other, they form cell groups that acquire such characteristics as flexibility, movement, reproduction, and nerve transmission. We know that all such body units as cells, tissues, and organs have a perfect integrated system. And yet it is still unclear how they combine and carry out the functions necessary to make eyes, the brain, bones, muscles, and so on, all of which are composed mainly of carbon, hydrogen, oxygen, nitrogen, and phosphate.

In short, many scientists are very curious about how brain tissues can perform hundreds of different functions (e.g., hearing, thinking, and feeling) even though they are composed of atoms.

Recent discoveries

For the last two decades, scientists have been working on small molecules, DNA, RNA, and proteins, in order to shed some light to the unknown aspects of life. The Human Genome Project (HUGO) is one of the largest projects and is scheduled to be finished by 2005. Its goal is to sequence the cell’s genetic material, which presumably numbers some 100,000 genes, and explain each one’s function(s). However, so far only 10,000 to 20,000 are known. And this despite the fact that scientists have spent centuries learning how molecules are formed and what kind of force drives the atoms to form molecules!

Several famous foundations, among them Yale University, New York’s Cold Harbor Laboratory, and Germany’s Max Planc Institute, have been researching questions related to the body’s structure. For example, how did it occur in such a small living cell, even though its building mechanism and systems are far more complicated than the system, which is all around us? How are dead cells expelled and replaced by new ones without disrupting any system’s continued functioning.

In short, living creatures still hold many secret–so many, in fact, that despite recent technological advancements many unknown subjects remain. What we know may be compared to a drop of water and the ocean.

DNA and genes

Excluding blood cells, one body contains millions of cells. For instance, there are approximately 5 million white blood cells within 1 mm3 of blood. Each cell has a nucleus (its brain), and each nucleus contains genetic codes (DNA). Such genetic information as hair and eye color, bodily height, and blood group is hidden within the folded DNA and packed onto 46 human chromosomes distributed. If we could unfold the DNA package within each cell, we would get a 2-meter long DNA strain.

In addition, each chromosome contains small DNA units (genes). Scientists estimate that there are about 100,000 genes, each of which has a unique function, in a human genome. For instance, there are globin (the major component of hemoglobin) genes on chromosomes 11 and 16, and individual genes on the X chromosome that enable us to see colors. Another gene on the X chromosome synthesizes a dystrophine protein within our muscles, other genes on chromosome 6 control ferine metabolism, another gene on chromosome 7 controls the ion traffic, and so on.

When we look at a gene’s structure, we realize that it they only are encoded by four letters (nucleotides): adenine (A), guanine (G), cytosine (C), and timin (T). The different orders of these four nucleic acids enable the gene to encode billions of protein amino acid combinations. The smallest gene, globin, is composed of 60,000 letters; the longest gene, distrophine, is composed of 2.4 million letters. If any letter is missing or is in the wrong place within the globin gene (e.g., AATG_ letter missing or AATTC letter change instead of AATGC), the ensuing point mutation, deletion, or insertion within the original order causes serious and incurable genetic diseases.

Many mutations occur within the functional parts of the 100,000 genes; however, they are instantly (10-10 second) repaired by the DNA ‘s repair mechanism. If not, serious diseases might occur. Interestingly, not all mutations cause genetic diseases, for while one mutation could be common within one human population, it might not occur so frequently within another one. Amazingly, our genes, composed of billions of letters (but only from A, T, C, and G) and always work in a harmony and collaboration so that our body can survive in a perfect manner. Therefore, spontaneous mutations or breakdowns are instantly repaired and old cells are replaced by new ones so quickly that we are not even aware of it.

Conclusion

In sum, the Creator has given each living entity a perfect and aesthetic body that functions in a most amazing manner. The only thing we have to do is thank the Creator for His generosity. That is perhaps the easiest task for us to do.

• References
• Thomas Gelehrter-William Wilkins, Principle of Medical Genetics Scientific American (January 1998).
• http://www.genome.gov/
• http://www.dnaftb.org/dnaftb/