Most of us have taken, or at least interacted with, medicine at some point or another in our lives. This can range from more “simple” over-the-counter drugs to more complex medicines specifically designed for exact illnesses. Considering the Covid-19 era we are going through and as search for a vaccine is at the highest possible speed, it is important to have at least a general idea on how medicines are developed for our use. This article aims to explore how a complicated mix of chemical compounds in a laboratory end up as pills on a shelf in your local pharmacy. We will also explore a brief history of pharmacology, where drugs get their names, how drugs come into fruition, the various affects that drugs can have on our bodies, along with the discrepancies that exist between them in regard to when, how, and why they should be taken.

Pharmacology is the study of the interactions that occur between a living organism and the chemicals that affect normal or abnormal biochemical functions. It includes the study of how a drugs can affect our biological systems, such as individual organs or an entire part of the body, and how the body overall responds to the drug. The discipline encompasses the sources, chemical properties, biological effects and, therapeutic uses of drugs. Substances with medicinal properties are considered pharmaceuticals, whereas drugs given for therapeutic purposes are usually called medications. Drug therapy, which is also called pharmacotherapy, is the use of drugs to prevent, diagnose, and treat signs, symptoms, and disease processes. When prevention or cure is not a reasonable goal, relief of symptoms can greatly improve quality of life and the ability to function properly on a day-to-day basis. Developing an understanding of this craft can allow us to better appreciate how molecules interact to form the drugs and medicines that can change our lives, and perhaps even allow us to contemplate their complex creation and existence.

In its most simplistic definition, a medication is a substance that is ingested or placed onto the body in order to cure a disease or condition (antibiotics are given to cure an infection), treat a medical condition (anti-depressants are given to treat depression), relieve symptoms of an illness (pain relievers are given to reduce pain), given to prevent diseases (flu vaccine helps to prevent the person from complications of having the flu).

Source of drugs

Historically, drugs were mainly derived from plants, animals, and minerals. Morphine, insulin, and iron are all commonly used examples of their respective sources. Belief in the curative powers of plants and certain substances rested exclusively upon traditional knowledge. But empirical information was not subjected to critical examination. Until the end of the 19th century, medicines were made by natural organic or inorganic products including mostly dried or fresh plants and their parts. These compounds might contain substances that possess healing properties or reactions that exert a toxic effect. It is important to remember that many fruits, vegetables, and plants still possess great power despite not having a “modern” origin.

Most drugs used nowadays are synthetic chemical compounds manufactured in laboratories which are synthesized by altering the chemical structure of an existing drug. The first drug of a particular group of drugs are called prototypes. For example, morphine is the prototype of opioid analgesics, and penicillin is the prototype of antibacterial drugs. Drug classifications and prototypes are defined and most new drugs can be assigned to a group. We must be hopeful and continue to search far and wide for cures for all  diseases, whether they be organic or synthetic, since our world is full of an infinite amount of possibilities and discoveries.

Drug names

The systematic naming of pharmaceutical drugs is called “drug nomenclature.” Drugs primarily have three types of names: chemical names, generic names, and trade names. The chemical names are the scientific names that often sound complex and are based upon the molecular structure of a drug. During development, the company will apply for regulatory approval of the drug by the relevant national regulatory agency, such as the U.S. Food and Drug Administration (FDA), and will be granted a generic name for it. Generic names usually indicate, via their stems, what drug class the drug belongs to. For example, oseltamivir is an antiviral drug because its name ends in the -vir suffix.

After development, testing, and regulatory acceptance of a drug, the pharmaceutical company gives the drug a trade name, which is a standard term in the pharmaceutical industry for a brand name or trademark name. Many drugs have multiple trade names which can reflect separate marketing strategies in different countries, manufactured by different companies, or both.

Drug investigation

A new drug investigation is the beginning of the journey of a chemical compound to a drug that will be used in clinics. The testing process of a chemical compound begins with animal studies to determine potential beneficial uses and also potential toxic side effects of the candidate compound.  The results from these animal studies are reviewed, and if the results are satisfactory, the compound then undergoes clinical trials in humans that people can voluntarily sign up for. Most clinical trials use a randomized, controlled experimental design that involves selection of subjects according to established criteria, random assignment of subjects to experimental groups, and administration of the test drug to one group and a control substance to another group.

Patent protection

New drugs that are developed by pharmaceutical companies will be covered under patent protection. This means that only the pharmaceutical company that holds the patent is allowed to manufacture, market, and eventually profit from the drug. This is seen as a return on the company’s investment that it took to develop the drug, which may require years of work and millions of dollars, along with an incentive for developing other drugs. Other pharmaceutical companies cannot manufacture and market the drug during the patent period.

Usually, the drug patent is awarded for around twenty years in the United States, however the number of years varies across countries and drugs. Pharmaceutical companies apply for a patent long before the clinical trial period even begins. The effective patent period after the drug has finally received approval is often around seven to twelve years. After the patented period expires the drug can be manufactured and sold by other companies. The drug is referred to as a generic drug at this point, and they are required to be therapeutically equivalent and much less expensive than trade name drugs.

Pharmacoeconomics

Pharmacoeconomics involves all of the costs that are accrued due to drug therapy and experimentation including those related to purchasing supplies, dispensing the drug, storing it, administrative fees, laboratory and other tests that are used to monitor patient responses, and losses from expiration. The length of a patient’s illness or hospitalization is also considered. While the most important factor is the health of the patient the costs for treatment are increasingly being considered as a major factor when choosing medications, and research projects that compare costs have greatly increased in recent years. The goal is to make it easier for patients to choose the most cost-effective drugs that combine high quality treatment at an affordable price. For drugs or regimens of similar efficacy and toxicity, there is considerable pressure upon doctors and pharmacies to prescribe less costly drugs for shorter duration.

Prescription and non-prescription drugs

In many countries, consumers have two legal routes of access to therapeutic drugs. One route involves a prescription or order from a licensed health care provider, such as a physician, dentist, or nurse practitioner. The other route is by over-the-counter (OTC) purchase of drugs that do not require a prescription. Both of these routes are regulated by various drug laws that change from country to country. Acquiring and using prescription drugs for non-therapeutic purposes, by persons who are not authorized to have the drugs or for whom they are not prescribed, is illegal.

The rejection of drugs in modern society

Nowadays, there are some people who deny various kinds of treatments because of their religious beliefs. This category of people is only a minority, as the majority of religions advocate for people to be healthy and to take care of their health as much as they can. In almost all belief traditions, the human body is believed to be a trust, and in case of any disease, the most appropriate and fastest treatment methods should be used. Even substances that are not normally permitted are allowed by scholars to be used if the person’s safety is concerned. For believers, the most important goal in life is to worship God, and for this to be possible the body must be healthy.

One day, people asked Prophet Muhammad, peace be upon him:

“Should we make use of medical treatment?”

He replied: “Make use of medical treatment, for God has not made a disease without appointing a remedy for it, with the exception of one disease, namely old age.”

People are encouraged to seek out those remedies and to use them with skill and kindness. Let us also remember that Jesus, peace be upon him, too, was very active in his ministry of healing. He showed by God’s permission miracles like curing the blind and the deaf, and bringing the dead back to life. Thus, religions do not refuse treatment with any available methods, and they even strongly encourage treatment and prevention of diseases.

Religions are also well known to treat stress, which wreaks havoc on the mind and body. It is still not known exactly how stress harms our health, but researchers have found that chronic psychological stress is associated with body’s losing its ability to regulate the inflammatory response. It has been shown that the effects of psychological stress on the body’s ability to regulate inflammation can promote the development and progression of disease. We know that religions and beliefs give people hope and significantly decrease the stress.

Human beings are the most precious creation, and health is necessary for us to achieve the purpose of our existence. Using scientific medicine together with faith and religion can help people to protect their health. Being the science of drugs and by investigating new drug therapies, pharmacology helps us exactly with that.

History of Pharmacology

Claudius Galen (129–200 A.D.) was the first person who attempted to consider the theoretical background of pharmacology.

Ali al-Tabari (838 A.D.) Medieval Islamic physicians used natural substances such as Papaver somniferum Linnaeus, poppy, and Cannabis sativa Linnaeus, hemp as a source of medicinal drugs. Although poppy had medicinal benefits, Ali al-Tabari explained that the extract of poppy leaves was lethal, and the extracts and opium should be considered poisons (4).

Theophrastus von Hohenheim (1493–1541), also known as “Paracelsus”, began to question doctrines from antiquity. He prescribed chemically defined substances with such success that professional enemies had him prosecuted as a poisoner. Against such accusations, he defended himself with the thesis that has become an axiom of pharmacology:

“If you want to explain any poison properly, what then isn‘t a poison? All things are poison, nothing is without poison; the dose alone causes a thing not to be poison.”

Johann Jakob Wepfer (1620–1695) was the first to use animal experimentation for pharmacological or toxicological actions.

Rudolf Buchheim (1820–1879) founded the first institute of pharmacology at the University of Dorpat (Tartu, Estonia) in 1847, which firstly made pharmacology as an independent scientific discipline. In addition to a description of effects, he strove to explain the chemical properties of drugs.

Oswald Schmiedeberg (1838–1921), together with his many disciples, helped to establish the high  reputation of pharmacology. He partnered with pathologist Bernhard Naunyn (1839–1925) to found the first journal of pharmacology, which has since been published without interruption.

After 1920, the pharmacological industry had their own pharmacology laboratories outside established university institutes. After 1960, departments of clinical pharmacology were set up at many universities and in industry.

References

1. Clinical Drug Therapy: Rationales for Nursing Practice – Seventh 7th Edition, Lippincott Williams &Wilkins.
2. Basic&Clinical Pharmacology, 12^th Edition, McGrawHill Lange.
3. Modern Pharmacology with Clinical Applications, Sixth Edition, Charles R. Craig and Robert E. Stitzel, Lippincott Williams &Wilkins.

Nowadays, almost everyone working in corporate America agrees that there is dog-eat-dog competition going on among rival companies as well as among candidates for jobs in these companies. The price companies pay for even a short period of “relaxation” in this non-stop race is very high: it is paramount to going out of business. The same holds true for individuals; a brief disengagement from the field or the market is likely to have serious negative consequences for one’s career. There is endless hassle without a break. Such stiff competition has devastating results at all levels: At the individual level, a wide range of psychological disorders and psychosomatic illnesses, such as stress and stress-related disturbances, and frequently sacrificing one’s values, such as altruism and humility, to survive in a job; at the family level, neglecting family members, especially children, who beg for genuine care and quality time from their parents; at the societal level, the loss of respect and care for one another, and indifference to problems in the society.

This article is neither a detailed description of the complete list of problems caused by the current system in many industrialized countries nor a practical remedy guaranteed to work the next day. It is obvious that the problems mentioned above cannot be fixed overnight or through band-aid solutions to only one aspect of life. With that in mind, it is also important to realize that any solution to any problem is influenced to a great extent by the underlying philosophy. Therefore, this article offers some fruits of reflection by Bediuzzaman Said Nursi, collectively suggesting a thought-provoking perspective to the disturbing picture given above. To this end, a unique description of the gracious environment offered by nature-in its unspoiled, pure form-is presented, as opposed to the suffocating climate-as briefly described above-in the superficial world that mankind has built for itself.

While being continuously busy with, or even overwhelmed by, the necessities of modern life have you ever reflected upon what Almighty offers us through Nature? Here are a few points to think about and thank for; please read with your heart as well as with your mind:

• All animate beings-from the most powerless to the most powerful-are given some suitable form of sustenance. A hand of infinite generosity gives feasts to all living things, none being forgotten. A little thought given to the variety of living things on the earth and the corresponding diversity of the types of sustenance they continuously beg for will suffice to realize the overall grace as a principle that is always at work.1

• By merely glancing at the material causes we can find clues that we have been provided with all our needs. Has it ever occurred to you that we are being dressed in the finest of fabrics-silk-by an insect that has no limbs and that we are eating wholesome and sweet honey from a bug that has a poisonous sting? Have you ever reflected on grapes? Bediuzzaman once saw a grapevine in a garden. He counted the bunches hanging from that grapevine, all of a thickness of two fingers. They numbered one hundred and fifty five. He counted the grapes in one bunch. There were around one hundred and twenty. He thought that if that vine had been a tap from which flowed honey-flavored water and if it had given a constant flow of water, it would have been just enough for to water the grapes, which in the face of extreme heat, contained hundreds of little pumps of the sherbet of mercy.2-3

• There is an inverse relationship between sustenance on the one hand and strength and willpower on the other. The more one relies on strength and willpower, the more difficult it will be to sustain one’s life. For example, it is the most helpless and delicate creatures that have the choicest food; for example, infants and the young of all species. The most impotent and least intelligent animals are the best nourished; like worms with fruit. On the other hand, the most powerful and intelligent animals experience difficulty in their livelihood. It is the wild beasts, such as lions, that have to relentlessly pursue their prey. The cunning fox remains thin in its search for food.4

• Compassion is apparent in relationships between living things. In the world of plants, look at the fruit-bearing trees. For example, the coconut tree, which carrying fruit that are like so many cans of ready-to-drink nourishment, gives sweet milk to its fruits while contenting itself with muddy water. Trees like the pomegranate and grapevines distribute a delicious beverage to their fruit and, in extreme heat, content themselves with mud. In the world of animals, look at the self-sacrifice mothers display. The hen has the courage to sacrifice its life for her chicks, throwing herself at a dog. She remains hungry and gives them food to eat. And she receives such pleasure in her duty that she prefers the pains of hunger and pangs of death.5-6

Regardless of how much we, human beings, have destroyed such a nourishing cradle in pursuit of our endless desires this is the description of our environment-in its pristine form-that has been prepared for humankind. One can easily realize what an important mistake it is for a guest, long awaited and shown such respect, to be in conflict with such a wonderful environment. Personally, I would be much happier to be in harmony with this environment than to be an inhabitant of a merciless, hostile one.

Just imagine for a second that aliens in space are watching the world. They will quickly realize that human beings, the most intelligent of living things, are those in the greatest agony; in contrast to all other members of the same world who are living content with their lives. I think we need to stop and take a careful look at our lives from above this hasty flow and decide what we are looking for.

Nature is out there, always ready to provide lessons that offer solutions to the problems in the world of humanity and I hope that the people tackling these problems will consult with this objective, age-old instructor and, where applicable, make use of the wisdom it offers.

Notes

• Nursi, Said, The Words, Sozler Publications, Translated by Þukran Vahide, Istanbul: 2002, The Tenth Word, Second Truth, p. 75.
• Ibid.
• Ibid., The twenty-second word; second station; sixth flash. p. 309.
• Ibid., p. 75.
• Ibid., p. 75.
• Nursi, Said, The Flashes Collection, Sozler Publications, Translated by Þukran Vahide, Istanbul: 2000, The Seventeenth Flash, Eighth Note, p. 171.

Other developments supported this trend, the most important being:

The invention of the silicon chip (1958-59). Subsequent improvements have so miniaturized computer components and compressed data that data transmission is now practically instantaneous. When combined with Web browsers, search engines, and the Internet, access to financial and other data can be exploited to its full potential. The U.S. Congress’ approval of Internet commerce and the falling prices of home computers and phone calls was a boon for transnational corporations (TNCs). Now they can micromanage their far-flung operations, direct money to the best economic opportunity, avoid taxes and financial losses, cripple unions and labor gains, skirt environmental legislation, and find other “creative” ways to increase profits.

The deregulation of financial capital (1973). This was signaled by abandoning the Bretton Woods system of fixed currency exchange rates, which had been maintained by America since 1944 and supported by its adherence to the gold standard, in favor of letting the market determine a currency’s value. Now that governments could no longer control the outflow of national currency, TNCs were free to move it as they wished.

Breaking the large banks’ and insurance companies’ monopoly on providing financial loans. With the rise of the bond market in the late 1960s, securitization of home mortgages in the 1970s, and “junk bonds” and the securitization of the international debt market in the 1980s, the current phase of globalization quickly blossomed.

These developments opened once-closed markets to millions of individual investors and mutual fund managers whose first concern is profit. As a result: “Not only can investors now buy and sell stocks and bonds from all over the world, not only can they now do that buying and selling from their home computers, but Internet brokerage sites are now giving them-for free-the information and analytical tools to make those trades, without ever having to call a broker. The more people do that, the more they will demand more information and analyses about different economies and companies, and the more easily they will move their money around, punishing the bad performers and rewarding the good ones.”¹

The underlying philosophy of increasing profits meshed nicely with a firm belief in social Darwinism. Developing and then applying “economic” Darwinism was a logical outgrowth. Just as individuals and species survive by adapting and becoming stronger, so companies survive by means of rapid adaptation.

This can take the form of corporate mergers or understandings, paying lower wages to and providing few if any benefits for overseas workers, and justifying everything in terms of increased efficiency. A new vocabulary has emerged for such activities: downsizing, outsourcing, streamlining, business restructuring or re-engineering, cost rationalization, retrenchment, redundancy, rationalization, risk minimization, profit alignment …

Benefits and Drawbacks

Those who dream of vast legions of Chinese consumers assert that globalization will make China a more open society. First, they say, Beijing’s official monopoly on information will end because foreign and local investors must have access to the Internet. Internal dissident groups can use it to contact sympathizers and publicize their causes at home and abroad.² Second, as China is drawn further into the world community, Beijing will have to adhere to international business law and treaties on workers’ rights, working conditions, fair payment, and so on. It also will have to adjust to globalization’s driving economic philosophy of neo-liberalization, which means liberalizing the economy, privatizing state-owned businesses and utilities, opening the financial and banking sectors, establishing transparency and accountability, and providing accurate financial data. Supposedly, such reforms will counteract China’s tendency to put politics and ideology above all other concerns. Third, those Chinese who work with foreign investors will learn about democracy, individuality, personal responsibility, human rights, governmental accountability, and how people in other countries actually live. In addition, foreign investment will open up new opportunities for Chinese entrepreneurs and those who want to improve their lives. They might even be paid above the normal hourly or daily wage, and thus can send money home to help their families.

Such arguments can be applied to many developing countries with only slight variations. These arguments sound great and really do have some merit, but reality sometimes does not conform to theoretical expectations. The following examples are by no means confined to the countries mentioned.

In Mexico, economic development is concentrated in Mexico City and along the northern border with America. The agricultural sector is largely ignored, despite the large numbers of people involved in it. Looking for debt relief, foreign investment, and entrance into the North American Free Trade Association (NAFTA), the government gutted Article 27 of its constitution, which made all communal land belonging to indigenous communities off-limits to foreigners and TNCs. It had to do this because America and Canada want access to Mexico’s untapped wealth, most of which is under indigenous-held land. The result was the Zapatista uprising on January 1, 1994, which continues to enjoy wide support, and a host of problems that drove the 71-year old ruling party from power in 2000.

In northern Thailand, villagers untouched by Bangkok’s modernization and development can see how their urban counterparts live thanks to television. Hoping to reap some of the benefits, some families sell their daughters to Bangkok’s brothels. Large sectors of Thai society and the government silently support this, finding an easy way out of this moral dilemma by saying that it is the girls’ karma. The result is an out-of-control AIDS epidemic and a booming sex-tourism business based upon the unbelievable exploitation of young women. Neighboring Cambodia has the same problem, while many Russian women see prostitution as the key to the good life.

In Ecuador, Amazonian Indian tribes and other affected peoples sued Texaco in an American court (1993) to force it to clean up the contamination it left behind. Texaco, which no longer operates in Ecuador, dumped “4.3 million gallons per day of toxic oil waste water over a period of 20 years … [but] claims the dumping caused no appreciable damage.” It also left behind more than 300 open waste pits contaminated with heavy metals and other carcinogenic compounds. “In their lawsuit, the plaintiffs cite a wave of deadly cancers, skin lesions, birth defects and other abnormalities among the areas indigenous peoples, and massive die-offs of plants, crops, and animals from air and groundwater pollution as well as poisonous “black rain.” In some villages near polluted water sources, the rate of cancer is 100 times higher than the historical norm.” The case has yet to be resolved.³ There are similar problems with Shell in Nigeria, Nike in Indonesia, Union Carbide in India, and Rio Tinto in Papua New Guinea.

Areas of Concern

Agriculture. The Green Revolution of the 1960s globalized agriculture and introduced the concept of “cash crops.” It also brought the promise of higher crop yields, reduced malnutrition, and rural development. However, along with it came traditional crop varieties and farmers displaced by agribusiness and hard-currency-earning cash cops, expensive imported fertilizers and pesticides, increased land distribution inequity, foreign corporate patenting of seeds and crop strains developed by local farmers over the centuries, and the diversion of financial and natural resources to agribusiness.

All of this undermined local agriculture, a devastating blow to indigenous farmers. Even worse, the Food and Agriculture Organization says that about 75 percent of all plant species have become extinct. In more than 80 of the 154 countries surveyed in 1995, this loss was attributed to “the spread of modern, commercial agriculture and the introduction of new varieties of crops.”⁴

Medicine. On February 1, 2001, America threatened to complain to the World Trade Organization about Brazil’s national and highly successful AIDS treatment program. By producing local and cheap generic drugs and delivering them for free, Brazil has halved its AIDS victims’ death rates and substantially reduced treatment costs. On April 19, 2001, after a protracted battle in South African courts, several pharmaceutical TNCs dropped their quest to block the South African government’s plan to import cheap generic drugs to treat its AIDS victims. Cilpa, an Indian company that produces cheap generic drugs for AIDS victims, routinely faces pressure from pharmaceutical companies and their governments to cease and desist.

In each case, the charge is the same: violation of the intellectual property and patent rights held by Western pharmaceutical companies. That these same companies are among the richest in the world, and that their clients are among the poorest countries in the world, is rarely mentioned. Prices have been reduced as a result of such negative publicity, but many victims in Asia and Africa still cannot afford the medicine they need to survive.

In the Amazon, researchers have discovered many plants and herbs with medicinal value from the indigenous peoples. However, most of them sell the data to the large pharmaceutical companies and both become rich. The Amazon’s people do not benefit; in fact, their situation deteriorates as even more TNCs descend upon them.

National Sovereignty. The rise of 24-hour computerized and almost instantaneous financial transactions and currency speculation makes it hard to know who is in control. Governments face an impossible situation: “Central banks and elected governments [are] regularly compelled to choose between [their obligations to domestic economies and the new force of the global market] … This was often a ‘no win’ choice for political leaders since yielding to the market’s idea of ‘sound economic policy’ frequently required them to depress their own economies, increasing unemployment or cutting social spending.”⁵

George Soros, perhaps the best known of all individual and institutional currency speculators, has humbled governments with this strategy. Working together, they humiliated the Bank of England in 1992 and destroyed Europe’s Exchange Rate Mechanism in 1993. Malaysian Prime Minister Mohamad blames Soros for the Asian economic crisis of 1997-98. No individual currency speculator can do much on his or her own, but when big players like Soros begin to move, others jump on the bandwagon. The results show who is really in charge of a nation’s economy and, to a certain extent, social policy.

Structural adjustment programs (SAPs) are another controversial matter. In the 1980s, America began tying its aid to World Bank and IMF economic prescriptions and reforms (reducing inflation, promoting exports, meeting debt-payment schedules, and decreasing budget deficits) and to facilitating increased American trade and investment.

However, they generally entail “severe reductions in government spending and employment, higher interest rates, currency devaluation, lower real wages, sale of government enterprises, reduced tariffs, and liberalization of foreign investment regulations…. But while government balance sheets may improve, SAPs have failed to establish a base for sustainable, balanced economic development … [and] have bankrupted local industries, increased dependency on food imports, gutted social services, and fostered a widening gap between rich and poor.”⁶

In addition, they tend to keep poor countries in debt, for new loans are needed to pay off existing debts and to qualify for future loans. Despite this, they remain the usual “cure” for countries seeking international financial aid and investment. This could change if anti-SAP protests continue, and if demands that lending institutions become more transparent and make allowances for social policies succeed.

Political Development and Human Rights. Decades of Western investment in oil-rich Middle Eastern and resource-rich African countries appears to have strengthened dictators of all persuasions. Instead of supporting human and religious rights in Chinese-occupied Tibet and Sinkiang, not to mention in China itself, American business interests persuaded Washing-ton to grant China permanent normal trade relations on September 19, 2000. Thus, China’s violations of human, labor, and religious rights no longer has to concern the American business community. Unfortunately, this seems to be the rule rather than the exception.

Conclusion

Global capitalism, based upon unfettered consumerism and the idea that continued profits through continued growth leads to ultimate happiness, now runs the world’s economy: “The culture-ideology of consumerism is the set of beliefs and practices that persuades people that consumption far beyond the satisfaction of physical needs is, literally, at the center of meaningful existence and that the best organized societies are those that place consumer satisfaction at the center of all their major institutions.”⁷

If this is true, human unhappiness is sure to increase. Poor people viewing the “real” lives of the rich through foreign television programs or movies see a lifestyle and possessions forever beyond their rich. Workers face constant job insecurity. Rural migrants in cities have their hopes dashed when they cannot find jobs. The media report the rise of sweat-shop and child labor, environmental devastation, a loss of corporate accountability and responsibility to their home bases, a hollowing of hard-won labor gains by threats of relocating overseas, and declining taxes as TNCs juggle their books.

Even those who benefit cannot feel secure. Their job might be outsourced in the interest of higher profits, abolished by corporate streamlining, or lost because they cannot acquire new skills fast enough. Shareholder dissatisfaction can destroy their companies, and job-related demands upon their time can make a normal family life and friendships impossible.

In sum: “Given their narrow premise, market economists never attempted to calculate all of the collateral damage that could also be attributed to the liberalization of finance-the capital investments destroyed when viable factories were abruptly abandoned, the economic output lost when economies grew more slowly, the public welfare costs from rising unemployment or declining wages, the instability for companies and nations caused by the sifting money values.”⁸

Economic globalization does have its good and bad points. But its emphasis on always-increasing profits as the way to ultimate happiness and meaning in our lives is misguided, for how can what is transient give lasting satisfaction? It has nothing to offer those who fall behind but dreams that will be fulfilled “sometime in the future.” And one day they will demand the fulfillment of those dreams…

Footnotes

1. Thomas L Friedman, The Lexus and the Olive Tree: Understanding Globalization (New York: Anchor, 2000), 71.
2. China’s first “cyber-dissident” was tried in Shanghai on December 4, 1998, “on charges of subversion for having given the addresses of 30,000 Chinese computer users to VIP Reference, a journal that Chinese dissidents publish in the United States.”
3. Ibid., 68.
4. Cristobal Bonifaz and Joseph C. Kohn, “Amazon Tribal Leaders Blast U.S. Judge For Blocking Texaco Pollution Case,” 31 May 2001. Online at: www.amazonwatch.org.
5. The State of the World’s Plant Genetic Resources for Food and Agriculture, Chapter 1: “The State of Diversity,” (Leipzig: 1996). Online at: http://web.icppgr.fao.org/ wrlmap_e.htm.
6. William Greider. One World, Ready or Not (New York: Simon & Schuster, 1997), 242.
7. Carol Welch and Jason Oringer, “Structural Adjust-ment Programs,” Foreign Policy In Focus, vol. 3, 3 (Apr. 1998). Online at: www.foreignpolicy-infocus.org/briefs/ vol3/v3n3sap.html.
8. Leslie Sklair, The Transnational Capital Class (Oxford, UK: Blackwell, 2001), 4-5. 8 Greider, One World, 250.

Other References

• Bales, Kevin. Disposable People: New Slavery in the Global Economy. Berkeley and Los Angeles: University of California, 2000.
• Barnet, Richard J. and John Cavanagh, Global Dreams: Imperial Corporations and the New World Order. New York: Touchstone, 1995.
• Korten, David C. When Corporations Rule the World. 2d ed.
• Bloomfield, CT: Kumarian Press, 2001. Madeley, John.
• Big Business, Poor People: The Impact of Transnational Corporations on the World’s Poor. New York: Zed Books, 2000.