We shall not dwell in detail on each of the great human virtues which distinguish human beings from all other creatures. However, one can gain a great deal of insight from studying deviated or unbalanced behavior, specifically in the context of living entities. A field of biology that has recently been recognized as “Systems Biology” is the detailed study of how an entire system is accommodated and “corrected” when there are deviations from “the most beneficial state.” These deviations consist of either a loss or an excess of a functional element within that system.

Systems biology

The universe around us is a place for exhibiting and training our skills and abilities; it is here that we are taught the lessons we need to learn during our journey through life. Looking at the mechanisms by which biological systems work we can see that events occur at exactly the time they are required to and that there is a purposeful and meaningful logic in the exact sequence of events. In how events take place one can see perfect order and a great deal of knowledge and wisdom. In fact, the human mind is awestruck by the orchestra of events that simultaneously takes place with the utmost precision and accuracy. Hence, the perspective provided by “Systems Biology” is an alternative to the reductionist viewpoint that accepts causality as the basis of understanding and explaining living systems.

One can see that when an event takes place in space and time it is not isolated, nor is it a part of a simple cause-effect mechanism. The inter-relation and connection of each event with every other event that occurs within a cell is a perfect example of such a system. This aspect of living biological systems gives us insights into the far-reaching consequences of our daily actions. On the surface, our daily actions may seem to be unconnected, irrelevant, and perhaps even meaningless; however, in reality our actions have a global effect on this universe. Just as all the parts of a tree are directed towards producing the fruit, every part of the universe is directed towards and subjugated for human kind, the fruit of the universe. It is as if the human being lies at the nexus of all other systems in the universe, as if it is connected to and is being served by every other existing system. As a result, all other systems in the universe are somehow connected to us. This means that our actions will have much greater consequences than we ever imagined, thus placing on our shoulders duties and responsibilities far greater and above all other creatures. Therefore, we are accountable for all our actions.

Cancer as a distorted state of cellular behavior

In systems biology, the changing of one component of the system, for example, an excess or a deficiency from the optimal (most balanced, most appropriate and the most beneficial) quantity, will lead to dramatic changes in all other components within that system. A disease can be defined as a state of affairs that has one or more components of the system that is being modified or changed in some manner. In this case, we shall take the example of cancer. The development of cancer in the human body is multi-stepped and it may take several years before the cancer is detected by modern technology. In fact, cancer begins when there is an error at the molecular level that is not put right, deep inside the cell. This error can be a single mutation in the reference manuals or “codes” called genes, or it can be another factor that is either inadequate or excessive. This mutation can happen in many ways; but why does it happen? There certainly must be an important reason for it happening. If we choose to understand the message then we will see that one of the purposes of this change could be to enable us to learn from the consequences of our actions.

How is this so? One only truly appreciates a system when it no longer functions properly. Hence, we can see that cancer may be the consequence of a single mistake that has not been corrected in one gene. This means that a single mistake can be amplified in such a way that it affects the entire being, and this is only because each event is connected to every other event. Understanding this will enable us to become more aware of our actions and to think more about their consequences before we act.

The connection between faith, moral virtue and the biological entity

In a healthy individual, cancer cells are always being created, however, they are immediately destroyed by specialized immune cells. The formation of full-blown cancerous tissue happens when the initial cancer cell is not destroyed. This clearly indicates that the health of the individual depends on the ability to destroy the cancer cell in the first instance. The tolerance or acceptance of the cancer cell as a healthy cell only occurs when the immune cells required for the destruction of the cancer cell are not activated or sensitized. In a similar manner, the moral and spiritual integrity of an individual depends on how aware they are of their mistakes, or indeed, whether they recognize their mistakes as mistakes. This is exactly the same process that is referred to as repentance in the three monotheistic religions. The one who repents feels remorse for their sins/mistakes and turns toward The One who will forgive sins. In an ideal society, this process is manifested as actively and strategically forbidding evil (or injustice) and advocating good, as without this process, without the application of good social justice will spread.

When the ability to recognize or sense a mistake is lost in an individual, then the person concerned will fail to regret any mistakes they make and begin to think all their actions are correct. Such a negative process is a delusion which leads the individual to think that they never commit any mistakes. The consequence of this process is a downward spiral in moral values and accountability of the individual and can be directly likened to a biological system that has allowed the growth of cancer. The individual who has committed many mistakes and who is oblivious or neglectful in repairing or making up for these mistakes is like a cancer cell that disrupts the entire tissue in which they are found. Unaccounted for (or unrepaired or mis-repaired) mistakes that have not been regretted will have great repercussions not only on the individual but on the entire community in which they live. These mistakes become part of a vicious cycle of events that lead the individual to even more excessive or deficient behavior, such as ingratitude, disrespect or prejudice. The individual becomes unaware of other systems around them, and becomes oblivious of the rights and needs of others, eventually acquiring arrogance, avarice, insolence, and finally turning into a vicious but weak monster that not only hurts itself but also others.

In a similar vein, the cancer cell can be likened to an individual who feels no remorse and no sense of urgency when a mistake or a sin is committed. The genetic mutations or unrepaired error(s) in cancer cells lead to loss of sensitivity of the environment. Cancer cells have many defects in the specific DNA repair mechanisms, therefore there is a high degree of chromosome instability in these cells.1 Furthermore, they are not affected by the signals that affect healthy cells, because all the check points in these cells have become desensitized. They are extremely aggressive cells that invade the tissues in the surrounding areas around them and rob the tissues of their primary resources. The cancer cells also do not die in the same way that healthy cells are discharged from duty. Cancer cells explode and die, thereby disrupting the entire system even more, while death in healthy cells is very organized and does not disturb the system.2

The degree of sensitivity of an individual to the validity of their actions depends on their conscientious understanding of what is right or appropriate and what is not. This is directly dependent on their reference point. If the reference point is from an all-seeing, all-knowing, and all-hearing source (i.e. a source that has the ability to see all the systems at once), then they can be sure that their action will be appropriate. Any other reference point that does not have a connection to this source is bound to mislead or lead to inadequate action under given conditions.

Similarly, the behavior of healthy cells is such that it is appropriate (or, as biologists would say, optimal) for the rest of the systems it is connected with. Hence, the events that place in a given cell are complementary and productive for the specific condition or configuration in space and time. When there is an error in any of the events or processes, it can be repaired, but when there is no error, growth continues. This indicates that the cell must have unity and a complementary nature with every other system in space and time in order to sustain health.

On the other hand, in a spiritually and biologically healthy individual, mistakes are repaired and are not long-lived, just like in the healthy cells that work unceasingly for the benefit of the being in which they are found. They respond to all their own needs as well as to those around them, they are not oblivious of others and they respect the individual rights of the people in their lives, especially the ones who have given the most to them, for example, parents, family, and friends. The balanced individual learns from the mistakes they commit, and they take care not to commit them again. In this way, as each action is connected to all the other actions of other entities, this individual becomes a means of an amplifying, productive cycle that has far-reaching consequences for the entire community.

The human being is brought into this world pure and with a perfect constitution. However, each individual’s unrefined ego must be trained so it can acquire the ability to recognize the mistakes that will interrupt its connection with the rest of the universe. These mistakes can only be recognized through great virtues like faith and knowledge of the Creator, knowledge of the self, gratitude, honesty, trustworthiness, sincerity, and humility, as well as perseverance in the face of adversity. It as if one who has been given these values can take the correct precautions to prevent any possible spiritual contamination, just as in a healthy biological system. Hence, faith enables a believer to behave in conjunction and in harmony with the myriad of systems in the visible and invisible universe with which it is connected. On the other hand, having unconscious faith or a lack of belief means all these connections have now been destroyed or are not strong enough. This isolates the individual from the multi-dimensional system of which it is part, finally leading to the self-destruction of the individual.

Sebnem Unlu, PhD, is a Research Faculty at University of Pittsburgh Cancer Institute, USA.

Note

1. R.A. Weinberg. The Biology of Cancer, Garland Science, 2006, p. 458.,
2. In cancer cells, programmed cell death, which is the mode of cell death in all healthy cells, is prevented. This means the mode of cell death in these cells will be another type of cell death, such as “necrosis,” where the cell explodes to release its contents, thereby disturbing the cells all around it.

The Aral crisis is the best example of an ecological problem with serious social and economic consequences, directly or indirectly connected with all the states of Central Asia. The critical situation caused by the Aral Sea drying off was the result of agrarian economy tendency on the basis of irrigated agriculture development and volume growth of irrevocable water consumption for irrigation.

The Aral Sea was once the fourth biggest inland sea of the world, located between Kazakhstan and Uzbekistan (formerly in the Soviet Union). It moderated the inland climate for many centuries through water evaporation, which gave life to the surrounding deserts of Central Asia. The Aral Sea also was inhabited by more than one hundred fish species and supported productive fishing industries. Some fifty years ago the Aral Sea was surrounded by prosperous fishing towns like Moynaq.

The water area of Aral has periodically expanded and contracted in the course of history. These changes have affected the climate and the state of the region and led to important migrations in history. In spite of the massive glacier melting in the North and South Pole because of global warming, which would be expected to increase the level of inland waters, the Aral is rapidly losing its water. Because of poor environmental planning and the negligence of humans, the Aral Sea is now dying and according to the experts it will disappear in less than ten years.

The Aral Sea started to dry off in the early twentieth century. In 1918 Lenin decided that the only two water supplies of the Aral, the River Amu and the River Syr should be diverted for irrigation of the desert to increase land for agriculture. The idea was to boost agriculture, and this worked for a short period of time. The Soviets or Uzbekistan became the world’s largest exporter of cotton, which they referred to as white gold. The area of irrigated lands increased from 3 million hectares to 8 million. The population of the region increased from 7 million (1940) to 50 million (2000). At the initial stage of this project which seemed a brilliant idea at first sight, the irrigated land built up the economy of the Central Asian Soviet States and produced millions of jobs. Although, the result of the project was brief joy and success, the price of poor planning turned out to be by far too high.

First of all, the government had decided to grow cotton in a desert terrain. Cotton farming requires lots of water, which would not occur naturally in the desert. They also increased the production of other crops like water melons, cereal, and rice. Diverting the rivers cut the supply to the Aral Sea, and due to evaporation, it began to shrink. The first irrigation canals were initiated in the 1930s; however, these canals were poorly built, extremely inefficient, and wasted more than 50% of the water. Even today in Uzbekistan only 12% of canals are leakproof. The level of the sea has gone down constantly ever since; in the 1960s it became obvious that the sea level was falling; there was an average 20cm fall per year until the 1970s, when the fall became 50–60cm a year, and now it is 80–90cm a year. Especially in the period of 1960–1980 the diversion of water doubled, which reflected on cotton cropping as much as on the decreasing sea level.

The loss of water exposed the salty sea bed in the Southern Aral. Dust storms spread salty soil into the irrigated areas. Farmers tried to fight against salt contamination by flushing the soil with large volumes of water, which makes its way back to the sea. In addition, farmers used high levels of pesticides and fertilizers to increase the efficiency of crop production. However, these chemicals leave traces of nitrogen and other salts in high amounts in the soil. By flushing the soil with water to reduce salt levels, pesticides and fertilizers were also washed out and further polluted the sea.

Even more unsettling is that the Soviet government knew that they would lose the Aral Sea; in 1968 an expert said “it is obvious to everyone that the evaporation of the Aral Sea is inevitable”; and they also knew that fishing would be hit but the sad fact is that the government saw the Aral as an “error of nature.” The consequences of cutting the Aral’s water supplies and the irrigation of the desert were the beginnings of serious ecological and social problems in the 1960s. The sea was lost to fishing and transportation. This business of “killing nature” has not only affected the people living in the immediate vicinity of the sea. They did lose their jobs and they had to restart their lives, but the whole environment was affected too. Loss of water caused an increase in the overall salinity of the sea. Besides that, the bed of the sea, which held toxic chemicals and pesticides, was now revealed. The local drinking water is hence contaminated. The Aral was once the habitat of more than 120 unique species; now it has only thirty-eight. Being a heat reservoir, it had a cooling effect on the environment, but now the temperature can go above 120 degrees, winters still being harsh. Poisonous dust and salt storms take their toll. Infant mortality, tuberculosis, cancer and lung disease are thirty times higher than normal levels because the water is contaminated by fertilizers, pesticides and salt.

Currently the sea has lost more than 60% of its surface area and more than 80% of its volume; as of 2004 the salinity is 45g/l, normal value being 10g/l. While shrinking, it has split into two lakes, the North and South Aral Seas, now 95 miles away from Moynaq, leaving vast areas of salty desert behind. A BBC reporter said, “What appears to be snow on the seabed is really salt. The winds blow this as far as the Himalayas. The children of Moynaq have made a playground out of the wrecks of ships which might have provided food and a future for them.” The drying out of the Aral may lead to even more serious consequences in future if measures are not taken soon. First, increased temperatures may lead to the degradation of mountain glaciers. This could be highly dangerous for the region because the glaciers feed the River Amu and River Syr, and they are the only remaining storage for the supply of fresh water and moisture. Second, the Aral’s sea bed emits massive amounts of salt and dust into the atmosphere. Polluted air is carried over the area by a powerful air stream. Traces of pesticides and salt from the Aral region are now found in the blood of penguins in Antarctica. Moreover, the pollution affects areas thousands of miles away, such as the glaciers of Greenland and the forests of Norway.

In 2003 Kazakhstan decided to make this split permanent by building a dam (Kokaral Dike) between the northern and southern parts. The restoration effort focuses on the Northern Aral which is small and less polluted. This seals the fate of the Southern Aral, and is synonymous with its vanishing. The northern water supply, the River Syr has been restored and diverted back into the sea. Although it will not be the same again for sure, planners think that fishing will be rescued and the North Aral Sea will stabilize the climate by smoothing out the high and low temperature extremes and increasing rainfall. The efforts have helped to lower the salinity level which has even allowed the reintroduction of fishing in this area. The result is surprisingly encouraging. There are other proposals like diverting the Volga, Ob, and Irtysh rivers but this would be very costly and could cause yet another catastrophe.

This story has everything in it. Humans who disregard the ecosystem takes the gift in nature for granted. As we can see, however, nature is not infinite and it is breakable. Hundreds of years may pass until the region completely recovers. The magnitude of the disaster is comparable in scope to those of Hiroshima and Nagasaki, and might be even worse. This is a great example of short-term greed and ill-guided economic moves disregarding the whole ecosystem and bringing consequences which have to be dealt with in the long run. In this particular case, there could have been other ways to avoid the damaging decision to cut the water supply of the lake fully, such as relying on a different type of crop which requires less water, or making more efficient use of water, and so on.

This disaster is a single example of the type of global catastrophe we might encounter again in the future. This being so it should be kept in mind when we think of our future. A lot of the damage humankind causes might still be avoided if we act firmly and quickly. This is not just necessary for our grandchildren or our children but even for our own generation since the consequences of ecological destruction are being seen more rapidly now. The widely known global warming cannot be belittled, and, as the Aral Sea example might have taught us, the consequences can be terrible. It is likely that more such unpredicted events will afflict us. Added to this, there are water pollution, deforestation, and the destruction of wet-lands. Every day we hear or read about these consequences of negligence and greed. But these geographical features are all in perfect harmony, and we cannot rudely and unthinkingly destroy them. As Lester Brown comments, “Previous generations have always been anxious about the future, but we are the first who decide if the Earth inherited by our children will be inhabited.”

Timur Ceylan is an expert engineer at AMD Technologies, San Francisco.

References

• National report: “On the environment state and use of natural resources in the Republic of Uzbekistan.” State Committee on Nature Protection of Uzbekistan. Tashkent, 1998.
• K.Isentaev. “Geological structure and perspectives of oil and gas reserves of the Aral Sea.” Workshop report. Almaty, 1997.
• Ministerial conference of Central Asia. “Assessment of the environment.” Aarhus, Denmark, 1998.
• J. Mahambetova. Non-government union. “Aral tenizi.” Aralsk, 1999.