More than 50% of the world’s population lives in urban areas, and the number is expected to rise to 70% by 2050. Studies show that urbanization is associated with an increased rate of mental disorders. For example, people living in big cities have a 20% higher risk of anxiety disorders and a 40% higher risk of mood disorders. In addition, people who are born and raised in a large city are twice as likely to develop schizophrenia. There are many possible causes for the correlation between urban life and the susceptibility to mental disorders, but one obvious explanation is that urbanization disconnects humanity from nature; this schism might lead to mental disorders. Scientists tested this hypothesis with a simple experimental design. They split 38 city people, who had no history of mental disorder, into two groups and asked them to walk for 90 minutes. One group walked in a grassland area with trees and shrubs, while the other group walked along a traffic-heavy four-lane roadway. Researchers measured participants’ heart and respiration rates as well as their brain activities through a neuroimaging method called arterial spin labeling (ASL) before and after the walk. Interestingly, researchers did not find a dramatic difference in physiological conditions like heart rates between the groups. However, they found big changes in brain activity, specifically in the subgenual prefrontal cortex, a region of the brain found to be active during ruminative thoughts. Rumination, in psychology, is defined as having repetitive thoughts of negative aspects of the self, such as thinking back over embarrassing or disappointing moments. Researchers found that participants who went on the nature walk showed marked reductions in the activity of the subgenual prefontal cortex, while those who went on the city walk had persistently active subgenual prefrontal cortexes. This suggests that a natural environment somehow reduces rumination. Scientists now aim to figure out what specific factor(s) in nature changes our brain activity. As increased urbanization is almost inevitable, understanding the link between nature and human psychology will help to design better urban plans and to come up with new ways to bring people to nature.

Singh GM et al. Estimated Global, Regional, and National Disease Burdens Related to Sugar-Sweetened Beverage Consumption in 2010. Circulation, June 2015.

According to a new study, sugary drinks alone caused 184,000 deaths worldwide in 2010. Scientists analyzed dietary surveys and large prospective disease studies from 51 countries that included 612,000 people between 1980 and 2010. The consumption of sugar-sweetened sodas and iced teas, sports and energy drinks, and fruit drinks – as well as homemade sugary drinks – were tracked (though 100% fruit juices were excluded from the study). Scientists estimated the contribution of sugary drink consumption to obesity, and of obesity to such diseases as diabetes, cardiovascular disease, and cancers of the breast, colon, esophagus, gall bladder, kidney, pancreas, and ovaries. Then, they calculated how many deaths from those diseases might have been exacerbated by sugary drinks. Analyses showed that sugary drinks caused 133,000 deaths from diabetes, 45,000 from cardiovascular diseases, and 6,450 from cancers. Death percentages linked to sugary drinks varied widely by country: low- and middle-income countries had the highest percentage of deaths. Years of campaigns and education have made most people well aware of the potential risks of high dietary fat. Although there are no health benefits to sugary drinks and they obviously cause many disorders, sugar consumption worldwide is not regulated at all. As alarming as this study was, the death tolls from sugary drinks do not illustrate the adverse effects of such consumption on the health of children. If younger people continue to consume high levels of sugary drinks at the current rate, death and disability from heart disease and diabetes in the future might be even higher than those seen in the current study.

Sobral D et al. Evidence for PopIII-like stellar populations in the most luminous Lyman-a emitters at the epoch of re-ionisation: Spectroscopic confirmation. The Astrophysical Journal, June 2015.

Astronomers recently reported that they have discovered some of the first generation of stars. When these stars exploded, carbon, oxygen, and other elements were generated which would eventually result in modern-day planets and life in the universe. These early stars have been estimated to be thousands of times bigger than the sun and to be composed of only hydrogen, helium, and traces of lithium. They burned for a few million years before they exploded in supernovas that ultimately started new generations of stars with elements like oxygen, carbon, and iron. Groups of astronomers recently captured the signatures of these first generation stars in Cosmos Redshift 7 (CR7), a recently discovered distant galaxy. CR7 is a galaxy from when the universe was about only 800 million years old. Analyses of the spectrum of lights from CR7, which have been traveling to Earth for 12.9 billion years, showed evidence of ionized helium, but not any sign of ionized carbon and oxygen, suggesting that the lights were emitted from the ancient stars. We all want to know where some of our essential elements – like the calcium in our bones or the carbon in our muscles – originally came from, and these recent advances in the field have shown us the beginnings of the elements of life for the first time.

Agrochemical control of plant water use via engineered abscisic acid receptors
Park et al. Nature, February 2015.

A recent breakthrough study reported that scientists successfully engineered drought-tolerant plants by adding a new piece of DNA to their genomes. Crops and many types of plants are increasingly challenged by hostile environmental conditions such as globally warming temperatures and diminishing water sources. Plants have very small openings called “stomata” that let carbon dioxide in and oxygen out. Each stoma is surrounded by two guard cells that control opening and closing using osmotic pressure. During daytime, the stomata lets plants allow carbon dioxide in and oxygen out. Since the air around the leaves is often drier than inside, water molecules also move out through the stomata – a process called transpiration. Under the stress of drought, plants produce a hormone called abscisic acid (ABA). When ABA is released, it makes guard cells close the stomata and in turn keeps the plant from losing the water. Scientists previously thought that if they could spray ABA on a whole field, plants would survive a drought. However, since ABA is very expensive and highly sensitive to light, this strategy never became an option. Then, scientists decided to take the commonly used fungicide mandipropamid and genetically engineered the plants to respond to mandipropamid as if it were ABA. By adding a new piece of DNA into genomes, plants ended up having slightly different ABA receptors, which can be efficiently activated by mandipropamid.  Researchers tried this approach on two different plants: tomatoes and Arabidopsis. When mandipropamid was sprayed, genetically engineered plants stopped transpiration, and hence were able to survive for 12 days without water. The next challenge is to test this strategy in real world crops. This approach potentially opens new avenues for crop improvement that could highly benefit a growing world population.

3D Vaccines to Cure the Cancer

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy
Kim J et al. Nature Biotechnology, December 2014.

Cancer is a devastating disease.  The World Health Organization (WHO) predicts that global cancer incidence rates will grow by nearly 60% to 22 million cases per year over the next two decades. The effective cure for cancer has not been developed yet, mostly due to its ability to escape the body’s immune system. Unlike infectious reagents like bacteria and viruses, cancer cells are actually our own cells that are broken and misplaced; they cause trouble as they grow. Scientists have been trying hard to develop vaccines that activate the immune system to recognize tumor cells as foreign and attack them. In a recent study, scientists reported that they designed a “3D vaccine” to effectively provoke the immune system to fight cancer. The 3D vaccine is composed of many microsized, porous silica rods submersed in liquid, where any combination of tumor antigens and immune-stimulating reagents can be loaded into.  Once the 3D vaccine is injected under the skin, it forms into a dime-sized scaffold that creates an “infection-mimicking microenvironment.” The scaffold then attracts the dendritic cells that patrol the body for harmful pathogens. When the scaffold was tested in mice, it showed over a 90% survival rate in animals that would normally die from lymphoma within 25 days. Further analyses in mice showed that the 3D vaccine can recruit, house, and manipulate immune cells to initiate a powerful immune response against cancer. As much as the discovery is promising, one should keep in mind that much more evidence will be required to establish 3D vaccines as a feasible way of combating human cancer.

Smoking Shrinks the Brain

Cigarette smoking and thinning of the brain’s cortex
Karama S et al. Molecular Psychiatry, February 2015.

Smoking is regarded as the single most preventable cause of disease, disability, and death. Past studies strongly linked smoking to cancer and lung diseases. A recent study now shows that smokers have a thinner brain cortex than non-smokers. The cortex is the outer brain layer in which critical cognitive functions such as memory, language, and perception take place. It is well known that the cortex becomes thinner with normal aging and cortical thinning is associated with cognitive decline and dementia. The study found that smoking accelerates this thinning process. Researchers analyzed brain MRI scans of 244 males and 260 females with an average age of 73, around half of whom were former or current smokers. Participants who had given up smoking for the longest time had a thicker cortex compared with those who had given up recently. Researchers cautiously suggest that the cortex might regain some thickness once smokers quit but the recovery is very slow and incomplete. For example, heavy smokers who had quit more than 25 years before still had a thinner cortex.

Various studies exist about these compartments – which controls the expression of the soul through the body, which is responsible for memory, intelligence, belief, hatred and love. The brain’s two hemispheres have different functions and specialize in different areas. For example, linguistic abilities and tongue functions are usually controlled by the left hemisphere, while musical abilities and the ability to comment and analyze complex images are controlled by the right hemisphere. However, it is not possible to state that the forebrain functions independently from the hemispheres of the brain. The Wernicke’s area, located on the upper tail of the temporal lobe, is responsible for language comprehension, and the Angular Gyrus that is a mediator between sound and vision, is responsible for linguistic and mathematical operations. For this reason, the Angular Gyrus is accepted to be related with superior consciousness and intelligence. Scientists have proven that intelligence and consciousness decrease more dramatically upon the destruction of these areas when compared to the destruction of the forebrain. Therefore, for the spiritual functions to be able to operate in the body, it’s essential that these areas of the brain function.

The more accepted view, at least today, is that spiritual characteristics and personality function independent of the brain. A convincing proof disregarding this view is that during many tumor surgeries, even though the body’s vital activities remain intact, after removing tissue from the brain, spiritual characteristics sometimes degrade. Another proof is the surgery performed to remove the forebrain of depressed patients (a prefrontal lobotomy). The patients vital activities were not disrupted upon surgery and their mood improved for a while. For a short amount of time, patients stopped suffering from serious neurological and psychiatric disturbances. However, when the patients were observed several years after the surgery, it was concluded that the patients lacked the functions of the forebrain and these surgeries were abandoned. The most prevalent side effects related to the removal of the forebrain were:

• Loss of the ability to solve complex social problems,
• Loss of the ability to take sequential steps in order to resolve a complex problem,
• Loss of the ability to multitask,
• Loss of determination, effort and desire to do activities,
• Loss of the ability for a community response when faced with a problem,
• Loss of ethical values and the feeling of shame,
• Loss of coherent thought even though the ability to speak and understand what is said is not lost,
• Instant emotional changes: from kindness to frustration, passion, violence and insanity,
• Inability to use artistic or naturally existing talents for the sake of a purpose.

These dysfunctions made it apparent that there was a correlation between the forebrain and spiritual characteristics.

Single neurons, not from the human brain, were inoculated in the lab and an experiment was carried out.. Studies showed that these neurons were not a means to highly intellectual capabilities, such as intelligence; whereas when neurons taken from the forebrain were inoculated and experimented on, it was found that they were a means to uniquely human capabilities like intelligence. Complex problem solving and the capacity to make discoveries were found to be correlated with the forebrain. It is not possible to explain such a fact without taking the soul into consideration. Spiritual characteristics such as sadness, happiness, joy, peace, patience, compassion, and love are all the results of complex interactions within the brain. However, it is not convincing to say that they are only results of electrical or chemical interactions within the brain.

The prefrontal area is where all thoughts coming from lower brain areas (such as sight, hearing, and feeling cortex areas, and the thalamus and hypothalamus) are gathered and processed to be enriched. Many information and memories gathered from different parts of the brain come together in the prefrontal area to be synthesized into deeper thoughts. Active memory is when different pieces of information are synthesized together and form a thought; and this thought is later acted upon. This allows to accurately surmise future events, and to plan for them.

It also allows for a rapid, appropriate response to the signals gathered by the five sensory channels. It allows for predicting the consequences of actions before performing them and for resolving problems of a complex medical, mathematical, ethical, moral, or philosophical basis. It can also postpone emotional responses for an appropriate time, measure the consequences of verbal and physical communications, use will power to measure the ethical and moral consequences of actions, and use information gathered from all channels to diagnose a problem. People who have damaged prefrontal cortexes, have serious difficulty synthesizing information and processing it to form coherent thoughts (active memory). This situation shows us that the prefrontal cortex enables consciousness and highly intellectual actions.

Another function of the prefrontal cortex is to enable focus about a specific topic. Taking this into consideration, the prefrontal cortex is semi related to attention. An existing proof for this is that people with damaged prefrontal cortexes are unable to concentrate and their focus is easily disturbed. Individuals whose prefrontal cortex has been removed or damaged can acquire a spiritual consciousness; however due to their handicap, they are unable to express their thoughts in a serial and sensible fashion for more than a minute. They can be easily distracted from the original subject. The prefrontal cortex allows an individual to accomplish a process of thought despite distractions, and allows for communication between the soul and the mind.

To sum it up, the prefrontal cortex is correlated with intellectual characteristics such as consciousness, intelligence, and self control, and also relates to how well we perform our moral values. For example, if the prefrontal cortex is unable to function, the individual does not feel shame anymore. This makes people believe shame is related only to the prefrontal cortex. However, the brain is merely a bridge between the body and the soul. Our brain is a bridge and curtain for our soul, which is the source of our spiritual characteristics. When we physically have a problem with our brain, the soul carries on its existence as before, however it is unable to express its consciousness, intellect, and will power in this material world.

Factors underlying variable DNA methylation in a human community cohort. L.L. Lam et al. PNAS October 16, 2012 vol. 109

The effect of environment on genes can be very profound. Our surroundings may not directly change our DNA sequence but it can surely dictate how our genes are transcribed. Epigenetics studies heritable changes in gene expression caused by non-genetic mechanisms, i.e. mechanisms other than the changes in the DNA sequence itself. DNA methylation is one of the major epigenetic modifications to regulate the gene expression. The addition of methyl groups on DNA sequence acts like a dimmer on a light bulb switch, which will turn certain genes on or off. A recent study showed that a person’s early life experiences shape their DNA methylation patterns. The research team discovered that childhood poverty (not socioeconomic status as an adult) is highly correlated to distinct methylation marks left on genes. Although children in rich and poor households have identical sets of genes, the degree of adversity or stress at home determines which combinations of those genes are activated or silenced through differential DNA methylation. One can imagine that such epigenetic changes might cause some alterations in the gene expression program of blind people to certain environmental signals or make them even more sensitive. Perhaps such changes could make some people more adaptive to harsher life conditions, hence enhance their survival. These findings suggest that environmental conditions early in life shape our epigenomes permanently thereby influence our life experiences, health and probably many other things that we are not yet aware of.

An alien planet next door

An Earth-mass planet orbiting α Centauri B. X.Dumusque et al. Published online 17 October 2012, Nature

Astronomers have just discovered an earth-size alien planet right next to our solar system. A new earthlike planet, named Alpha Centauri, is just 4.4 light-years away. That’s 40 trillion km away from earth! Although this rocky planet’s mass is similar to Earth’s, it orbits much closer (25 times closer than the Earth) to host star Alpha Centauri B. As a result, a year lasts 3236 days and the surface temperature of the planet reaches around to 1200 °C, which makes the planet incapable of supporting any life form we know. However, solar systems with a rocky world are usually predicted to have multiple planets. One possibility is that that Alpha Centauri A, the bigger sibling of Alpha Centauri B, might host some yet to be discovered unknown planets with more habitable zones. Although this recent discovery has sparked people’s dreams to travel to another star system outside of our planetary system, such an exploration mission unfortunately seems impractical in the near future. Even a cell phone-sized probe that is accelerated to 10% of the speed of light would need to travel non-stop for 40 years to reach the target. So, what is the next best thing to do? Will it be taking photos or dropping probes on the planet’s surface to study a potentially modified atmosphere? It seems like while astronomers work hard on the identification and characterization of this new star system, scientists should focus on developing super-fast propulsion systems, which will perhaps include new concepts like nuclear rockets and antimatter fusion drives.

Bad memories, substitute or suppress

Opposing Mechanisms Support the Voluntary Forgetting of Unwanted Memories
Benolt RG et al., Neuron, Volume 76, Issue 2, 450-460, 18 October 2012

For the nervous system, forgetting a memory is almost as complicated as creating one. A recent study probed the mechanism of how the brain allows us to voluntarily forget unwanted memories. Researchers utilized functional magnetic resonance imaging (fMRI) to examine the brain activity of participants who had learned associations between pairs of words and subsequently attempted to forget these memories by either blocking them out or recalling substitute memories. The fMRI results showed that two separate forgetting strategies looked equally effective yet they seemed to use different neuronal circuits in different parts of the brain. For memory suppression, dorsolateral prefrontal cortex inhibits neural activity in the hippocampus which is a critical region for recalling past memories. On the other hand, memory substitution specifically activates caudal prefrontal cortex and midventrolateral prefrontal cortex that are known to bring specific memories into awareness in the presence of distracting memories. These findings can help us to better understand the mechanisms of memory disorders such as posttraumatic stress disorder, and may ultimately help to develop effective treatments. At a more personal level, this study may direct us to explore how we deal with our unpleasant or unwanted memories. We might be surprised to realize that one approach might be working much better for us than another one. In other words, neuronal wiring in our brain might simply favor one approach over another.