Termites are 1-2 cm in size, but they live in mud towers that can grow to five meters tall. The scale, between termite and tower, is comparable to that between a human and a skyscraper. When their life style, which seems chaotic from the outside, is investigated, one finds that termites maintain social lives within perfect urban communities. These wondrous mini cities feature air conditioning and ventilation systems, in addition to a queen chamber, and rooms for incubation and juveniles.

An instinctual sense of solidarity that has been ingrained among living organisms also plays an important role among termites. They display an amazing form of cooperation in matters like foraging and defense. As termites live in colonies, they follow a particular arrangement of duties. The queen is in charge of new generations; workers meet the nest’s needs, and soldiers are responsible for its defense. When necessary, workers also participate in defensive tasks. One of the termite’s defense mechanisms, which amazed scientists, was recently discovered in June 2012.

Jan Sobotnik, with the Academy of Sciences of the Czech Republic, and Thomas Bourguignon, of Université Libre de Bruxelles at French Guiana, discovered an unseen feature of the termite species Neocapritermes taracua. The workers of this species are, in a sense, enlisted to military duty when they “retire” due to old age and an inability to forage due to weakened mouths. They serve the defense of the nest as something of a chemical weapon specialist. When the colony is under attack, these veterans blow up a droplet-size balloon filled with a type of chemical generated in between segments of their neck and dorsal region.

When worker termites get older, blue crystal chambers, which resemble backpacks, grow on their two shoulder blades on their back. These crystals are a kind of protein called hemocyanin that contains copper, and they join together with saliva when under threat. This fusion causes a chemical reaction. The end product is a sticky liquid, like a gel, that is compressed to expand and then burst. This can fatally injure a predator. The poisonous substance that is dispersed causes rotting upon contact. The chemical formula of this blue crystal substance, along with its reactions, are still unknown.

Researchers from Oregon University (USA) reported that the mouth of an ant is worn down by age. When this occurs, these senior individuals, which used to cut leaves, now take on different jobs, like carrying the leaves. Leaf cutter ants, which are also known as the ranchers of the animal kingdom for their ability to cultivate fungi in their nests, can cut and carry leaves whose weight can be up to 50 times their body weight.

The leaves that are transported to the nest comprise the main ingredient required for the growth of fungi in a suitable environment regulated for the right temperature and humidity. This fungi is ultimately used to feed the colony. This is a fine example of senior members of a community staying active in a new role. And this is not just unique to termites: research shows that members of animal societies adapt to changes in their lives, and continue serving their colonies even if they lose some dexterity.

Our universe seems to be set up this way. As mentioned in the above examples, there is a change of occupation instead of just retirement. Just as there is no termite that stops working, there is no bird that says “I do not want to fly anymore because I am old,” or no tree that says, “I will retire and stop giving fruit because of my old age.” Organisms adapt to new conditions and find new ways to provide for our planet.

Our aging planet will continue rotating and the sun will keep smiling on us with its heat and light until the end of such organism’s lifetimes.

When it comes to humans, continuing with occupation and business as much as they can should be the desired effort. Especially for charity work, no one should mention retirement or leave of a duty, and receding to one’s quarters. Let us renew our intentions now, and review our senior living plans.

Hierarchy of hematopoietic stem cells

The blood system, also known as hematopoietic system, has enormous regenerative capacity to maintain functional mature blood cells that arise from highly proliferative but short-lived progenitor cells. Those progenitors in turn are generated from very rare blood stem cells called hematopoietic stem cells (HSCs). HSCs are one of the most studied stem cells in our body which has greatly shaped our thinking on the features of adult stem cells. These stem cells are kept at the bone marrow in close proximity to bone cells and other supporting cells forming the specialized home known as niche. In several aspects, a niche resembles a cellular stronghold that a queen lives in a safe and protected environment.

The interaction of stem cells with the niche is crucial as this prevents exhaustion of stem cells from uncontrolled cellular divisions and proliferation. While active progenitors account for the generation of mature blood cells, hematopoietic stem cells function as a reserved cell population. Interestingly, we observe the importance of the balance between those two cell populations in the aging process. Although the number of HSCs increases in aged animals, there is a decline in self-renewal of HSCs.

Other protective mechanisms include the low proliferation rates of HSCs in a relatively quiescent state, residing in a low oxygen environment [3], a relatively low degree of metabolism and preferential use of glycolysis as energy source, and additional protection mechanism against oxidative stress.

Low in oxygen but a good place to be!

Stem cells as the cell bank of the body are protected against internal and external insults by a number of mechanisms. Stem cell niche not only provides an environment that they can survive but also poses the lesser degree of internal and external insults. Those possible stresses on cells include, but not limited to, UV exposure, radiation, toxic chemicals, and free oxygen species that cause various damages in the cell including mutations in DNA (Fig. 3). Cells respond to those external and internal issues by various ways such as senescence (loss of stem cell activity), cell death or DNA repair. For example, blood stem cells mainly house in the bone marrow next to osteoblastic lining (blood-forming cells) and endothelial cells where they form the hypoxic (low oxygen tension) endosteal region. This hypoxic niche of HSCs provides lower levels of oxygen so that there are lower levels of free oxygen radicals that mainly arise from electrons leaking from mitochondria during oxidative phosphorylation. In addition, it has been shown that HSC express higher levels of hypoxia inducible factor-1α, a master regulator at low oxygen tension with hundreds of downstream targets regulating various aspects of metabolism including defense against oxidative stress and survival at low oxygen environment. It has also been shown that hypoxia increases self-renewal abilities of HSCs, thus keeps them healthy and functional for longer periods.

Protection from detrimental effects of reactive oxygen species (ROS)

Excess amounts of reactive oxygen species are detrimental to cells. ROS are found to cause hematopoietic stem cell defects as shown in mouse lacking FoxO and Atm genes. In those mutant mice, the hematopoietic defects could be rescued by the use of an antioxidant N-acetyl-cysteine. Anti-oxidants are one of the scavengers that diminish unwanted effects of reactive oxygen species. A number of fruits and vegetables such as beans, blueberry, strawberry, and apple are known with their high content of anti-oxidants. It is amazing to observe anti-oxidants being placed into our sustenance just as much as in some special genes (such as SOD2 and Hypoxia Inducible factor-2α) that provide additional protection for cells. Amazingly, stem cells show high levels of ROS scavenger genes.

Low metabolism provide protection for stem cells

Recent studies demonstrate that hematopoietic stem cells have lower rates metabolism as measured by lower oxygen consumption, lower ATP content and higher lactate production (an end product of cytoplasmic glycolysis) [4]. This means that stem cells produce and consume lesser energy (ATP) compared to more differentiated cells and the by-products of the energy production are kept lower. As higher energy demand brings higher rates of internal insults like production of ROS which is associated with aging and cellular damages, HSCs are granted with another protective mechanism by preferential use of glycolysis (anaerobic) instead of oxidative phosphorylation (aerobic).

Hematopoietic stem cells are quiescent

Another defense mechanism is the quiescence of stem cells which is associated with slow cell-cycle progression. Quiescence of stem cells means that they are kept at a resting, inactive state thus sustaining a self-renewing HSC compartment for life. Because when cell divides, they have to undergo thousands of chemical reactions including making a copy of the three billion letter long DNA, which puts cells at risk to get mutations. Thus, they don’t undergo division unless there is a stimulus. In addition, it has been found that HSCs divide only once every 145 days on average.

There are a number of studies indicating that there are signals in the niche that keeps HSCs in a quiescent state. Tie2/Ang-1 signaling, for instance, has been demonstrated to contribute to the maintenance of HSCs by inducing quiescence. While Ang-1 is expressed in the mesenchymal/stromal cells of niche, its receptor Tie2 is expressed at HSCs. In addition, it has been shown that Ang-1 can inhibit HSC division in culture and promote quiescence of HSCs in the bone marrow [5].

It is also reported that the cell adhesion molecules that allow physical interaction between stem cells and their niche components may participate in regulation of stem cell quiescence through a process called contact dependent inhibition of proliferation. For instance, it has been found that cell adhesion molecules such as N-cadherin, β1-integrin, and osteopontin might be involved in the regulation of cell cycle status of HSCs [6].

One advantage of quiescence of HSC comes from the lower susceptibility of slowly proliferating cells to radiation than other cells due to the expression of cell cycle inhibitors like p21 and anti-apoptotic (controlled cell death) machinery like ATM in HSCs. In addition, studies in p21 (a cell cycle inhibitor gene) knockout mice suggest that maintaining cell cycle quiescence is directly linked to self-renewal of HSCs [7].

Toxics are exported from hematopoietic stem cells

There are other issues concerning external insults against toxics and unwanted chemicals. An HSC population described as side population has been equipped with a number of transporters such as ATP Binding Cassette (ABC) transporters, P-glycoprotein (P-gp/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) on their membrane providing high efflux ability [8]. They play an important role in the excretion of drugs and endogenous compounds. Those transporters work actively when there is an entrance or excess of such chemicals thus keeping damage minimal.

HSCs are placed in such an environment that even minimum damages by internal and external insults are prevented by different defense mechanisms including residing HSCs in the hypoxic niche, expression of ROS scavenger genes, preferential use of glycolytic metabolism, quiescence nature of HSCs, and removal of toxins by ABC transporters. It is very wise to home such an important cell in a place where it can prosper with a carefully balanced rate of cell division and metabolism. Hypoxic niche seems key to the protection of hematopoietic stem cells by supporting self-renewal and preservation of hematopoietic functions both at the same time. The presence of these protective systems that are graciously placed in our cells with perfect measurements provides an elusive mechanism to ensure healthy life-long reservoir of HSCs.

Ali Fethi Toprak is a PhD candidate at Southwestern Medical Center, Texas University.

Selected References

1. Kobayashi, C.I. and T. Suda, Regulation of reactive oxygen species in stem cells and cancer stem cells. J Cell Physiol, 2012. 227(2): p. 421-30.

2. Li, L. and H. Clevers, Coexistence of quiescent and active adult stem cells in mammals. Science, 2010. 327(5965): p. 542-5.

3. Eliasson, P. and J.I. Jonsson, The hematopoietic stem cell niche: low in oxygen but a nice place to be. J Cell Physiol. 222(1): p. 17-22.

4. Simsek, T., et al., The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche. Cell Stem Cell, 2010. 7(3): p. 380-390.

5. Arai, F., et al., Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell, 2004. 118(2): p. 149-61.

6. Yamashita, Y.M., D.L. Jones, and M.T. Fuller, Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science, 2003. 301(5639): p. 1547-50.

7. Cheng, T., et al., Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science, 2000. 287(5459): p. 1804-8.

8. Huls, M., F.G. Russel, and R. Masereeuw, The role of ATP binding cassette transporters in tissue defense and organ regeneration. J Pharmacol Exp Ther, 2009. 328(1): p. 3-9.

9. Antioxidant Riches Found in Unexpected Foods. Retrieved from http://www.webmd.com/food-recipes/news/20040617/antioxidants-found-unexpected-foods, January 31, 2012.

At the beginning, I really did not pay much attention to him. He was very small, almost invisible and harmless-looking. However, he started to reproduce all of a sudden. Now, there were billions of his copies on one of my leaves. Everything was happening so quickly. They were taking me over. Something had to be done urgently.

As plants, we cope with such environmental stresses everyday. If the stress factors affecting us are living organisms, such as bacteria, harmful insects, and weeds, we call those as biotic stresses (1). On the other hand, if we are exposed to drought, salinity, heat, cold, and deficiency or excess of a chemical in soil, those are abiotic stresses for us. Both biotic and abiotic stresses impair our growth and even lead to our death sometimes. Therefore, stress response mechanisms are very important for us. Unfortunately in the United States alone, crop losses due to plant pathogens amount to billions of dollars (2). As we are the main food resource for the humans and assigned for so many other important functions on earth by God, our health and productivity is taken very seriously by scientists. So, it is of great interest to them to find out how our defense responses against microbes work. If scientists learn what is going on when a plant is infected by pathogens thoroughly, they can introduce better resistance mechanisms into economically important crop plants via genetic engineering.

Oh “NO,” I am stressed!

Unlike animals, we are firmly attached to the ground so we can not escape from stress factors. However, thanks to God, we have fascinating defense mechanisms against environmental challenges. First of all, I need to know who this infectious agent (pathogen) is so that I can trigger a stress response mechanism against it. The interactions between me and these microbes are controlled by my receptor proteins and Pathogen-associated molecular patterns, or PAMPs, delivered by the pathogen. PAMPs help pathogen growth by suppressing my defenses and manipulating my metabolism (3).When I recognize a PAMP by my receptors, I activate a set of defense mechanisms known as the hypersensitive response (HR) to arrest and terminate pathogen growth before it terminates me (4). Just before or in conjunction with HR, I increase synthesis of several families of pathogenesis-related (PR) proteins in my infected part (5).

Do you want to know what I do after I identify a pathogen? I bet you do, so I am going to tell you about the other components of my signal transduction cascade that is activated upon brutal attack of microbes (Fig. 1). One of the early steps in this signaling cascade is the elevation of cellular calcium (Ca (2+)) levels mediated by my plasma membrane and channels such as cyclic nucleotide gated channels (CNGCs). After the initial Ca(2+) increase, I activate some of my calcium-binding proteins (calmodulin or CaM) and protein kinases, which modify other proteins by chemically adding phosphate groups to them, and ultimately I generate nitric oxide (NO) and reactive oxygen species (ROS) (6). ROS function as signaling molecules that coordinate a wide range of diverse plant processes, such as growth, development, stress adaptation, and cell self-destruction (programmed cell death) (7). However, the real reason I produce ROS under attack is to use them as local toxins to form unfavorable conditions for pathogen growth and reproduction. NO plays a key role in our immunity in synergy with ROS regulating responses that include defense gene expression and programmed cell death (8). As a result, I utilize both ROS and NO to say “NO” to the pathogens. Other important signaling molecules I utilize are salicylic acid and jasmonic acid. These essential plant hormones are chemical messengers that enable me to respond to my environment. Salicylic acid, SA, which is chemically similar to but not identical to the active component of aspirin (acetylsalicylic acid), is involved in the defense against pathogens that feed and reproduce on live host cells and activates signaling processes providing systemic acquired resistance, protecting the plant from further infection after an initial pathogen attack (9) (Fig. 2). On the other hand, jasmonic acid (JA) induces defense against pathogens that kill host cells for nutrition and reproduction (10). Another hormone in the complex cross talk of signaling pathways regulating my defense responses to microbial attack is ethylene, ET (11).

Although, I have not even told you all the details, I bet you have started to think that all these signaling cascades, regulators, hormones, molecular patterns, and receptors are highly complicated. Do not worry; I am not planning to tell you all the molecular mechanism(s) and relevant pathways I execute during biotic stress responses. If I do, then what will the plant scientists who are interested in plant pathogen interactions do for the rest of their lives? Instead I am going to briefly describe to you what strategies I use to prevent the spread of infection that the small microbe started.

Initially, I build physical barriers around the infection by increasing my cuticle, a protective waxy covering, and cell wall thickness, and then I release antimicrobial compounds, such as phenolics and phytoalexins to the sites of invasion (11). However, this effort is usually not enough to stop the microbes. Therefore, most of the time, the cells in the local region surrounding the infection decide to commit suicide to limit the growth of the pathogen through programmed cell death, which is a highly coordinated and sophisticated phenomenon. This resembles to the firefighters’ strategy to put down a forest fire. Firefighters control flames by cutting down trees, clearing brush away from the existing edge of the fire. This way they can form borders to mitigate the forest fire.

While I am fighting the infection, I also try to confer a long-lasting protection against this pathogen. I send mobile signals like salicylic acid to activate defense responses in distal tissues in case a secondary pathogen attack might occur there (12). Salicylic acid also induces numerous genes that encode PR proteins with antimicrobial properties (13).

I have done all those things I have told you here and a lot more that are still undisclosed to humans in a really short time because it was a matter of “to be, or not to be.” After all that stress, I have won the battle against the microbe at least for now. I have gained a life experience and will defend myself better in the future. I am recovering, but unfortunately my leaf, where all that fighting happened, has a big lesion, an abnormal tissue, which was formed when my poor cells died during the attack (Figure3).

As you can tell from my story, plants get stressed out too. However, we are not stressed due to problems at home, school, or work or spending time stuck in traffic. We deal with salinity, heavy metals, temperature, drought, lack of nutrition, herbivores (insects, mammals, etc.), and pathogens. Thanks to God that He gave us astonishingly complicated response mechanisms to resist all sorts of stresses to some extent, especially biotic stress. Otherwise, we might have become extinct. Can you imagine a world without us? You would have no more oxygen in the air, no more food for animals and humans, no more papers or books, no more clothes, no more furniture, no more blooming beautiful gardens, no more roses for your loved ones, and no more trees, which hold the soil in place so that wind and rain don’t cause severe erosion and destruction of homes for so many species. In addition, there will be fewer resources for drugs and dyes. Oh my God, you are the Most Gracious and the Most Merciful. Thank you that You created us, shaped us and gave us smell, taste, color, and resistance to stresses.

Safiye Arslan is a research fellow in the area of biological chemistry and lives in Nevada.

References

1. Holopainen JK, Gershenzon J. 2010. “Multiple stress factors and the emission of plant VOCs.” Trends Plant Sci. 15,176–184.

2. http://www.apsnet.org/online/feature/biotechnology/

3. Wulff BB, Chakrabarti A, Jones DA. 2009. “Recognitional specificity and evolution in the tomato-Cladosporium fulvum pathosystem.” Mol Plant Microbe Interact. 22, 1191–202.

4. Genger RK, Jurkowski GI, McDowell JM, Lu H, Jung HW, Greenberg JT, Bent AF. 2008. “Signaling pathways that regulate the enhanced disease resistance of Arabidopsis ‘defense, no death’ mutants.” Mol Plant Microbe Interact. 21, 1285–96.

5. Klessig DF, Durner J, Noad R, Navarre DA, Wendehenne D, Kumar D, Zhou JM, Shah J, Zhang S, Kachroo P, Trifa Y, Pontier D, Lam E, Silva H. 2000. “Nitric oxide and salicylic acid signaling in plant defense.” Proc Natl Acad Sci USA. 97, 8849–8855.

6. Ma W, Berkowitz GA. 2007. “The grateful dead: calcium and cell death in plant innate immunity.” Cell Microbiol. 9, 2571–85.

7. Gechev TS, Van Breusegem F, Stone JM, Denev I, Laloi C. 2006. “Reactive oxygen species as signals that modulate plant stress responses and programmed cell death.” Bioessays. 28, 1091–101.

8. Asai S, Yoshioka H. 2009. “Nitric oxide as a partner of reactive oxygen species participates in disease resistance to nectrotophic pathogen Botryis cinerea in Nicotiana benthamiana.” Mol Plant Microbe Interact. 22, 619–29.

9. Beckers GJ, Spoel SH. 2006. “Fine-Tuning Plant Defence Signalling: Salicylate versus Jasmonate.” Plant Biol (Stuttg). 8, 1–10.

10. Spoel SH, Johnson JS, Dong X. 2007. “Regulation of tradeoffs between plant defenses against pathogens with different lifestyles.” Proc Natl Acad Sci USA. 104, 18842–7.

11. Bouchez O, Huard C, Lorrain S, Roby D, Balagué C. 2007. “Ethylene is one of the key elements for cell death and defense response control in the Arabidopsis lesion mimic mutant vad1.” Plant Physiol. 145, 465–77.

12. Ficke A, Gadoury DM, Seem RC, Godfrey D, Dry IB. 2004. “Host Barriers and Responses to Uncinula necator in Developing Grape Berries.” Phytopathology. 94, 438–45.

13. Liu PP, Bhattacharjee S, Klessig DF, Moffett P. 2010. “Systemic acquired resistance is induced by R gene-mediated responses independent of cell death.” Mol Plant Pathol. 11, 155–60.

14. Durrant WE, Dong X. 2004. “Systemic acquired resistance.” Annu Rev Phytopathol. 42, 185–209.

The second leading cause of death in the United States, after heart diseases, is cancer, claiming around half a million lives every year.(1) People today are concerned more than ever about cancer and its terrible consequences. However, in the light of recent scientific findings, a very different picture can be seen: In an environment with increasing carcinogens, it is actually surprising to find most populations are cancer-free. This is because our bodies are equipped with systems to prevent cancer formation.

Cancer research over the last two decades has shown that cancer is a disease of the genome.(2) Changes in the DNA, called mutations, disrupt the regular cellular networks that control a state of delicate balance. People are continuously exposed to varying amounts of chemicals that have been shown to cause mutations in the genome which may lead to cancer formation. Exposure to harmful chemicals can occur due to being in an environment where these agents are present in the food, air or water, and also due to our own metabolism which may produce these chemicals. It has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the formation of the majority of human cancers.(3)

Even though some of the mutations caused by these agents hit cancer-critical genes, cancer does not immediately develop. Furthermore, cancer is mostly seen in old age, when many mutations have accumulated in the genome. The reason why we are protected from developing cancer, even though our DNA is under numerous types of attacks everyday, is that our cells are equipped with several lines of defense against cancer formation. These built-in defenses include DNA damage repair systems, external and internal controls of cell division rate, and the programmed death of cells. All of these defenses have been given to our cells in order to protect us from getting cancer. If we were not to have these defenses, cancer would be a daily occurrence for every one.

It is possible to say that a cell’s first defense against cancer is similar to the regular maintenance of a car. One has to replace the brake pads, change the oil, etc., so that the aging of the parts will not cause failure that may lead to an accident. Similarly, chemical carcinogens from environmental pollution, ultraviolet rays from the sun, radiation from various sources, etc. all cause multiple types of damage in the DNA molecule. Therefore, our cells and genome need maintenance as well. This function is carried out by groups of proteins called DNA repair complexes. DNA repair mechanisms have been designed to correct the DNA damage before it can lead to inheritable mutations.(4)

If the DNA damage repair systems are intact, most of the damages to the genome are dealt with before they can cause problems. We observe the extent of attacks that can damage the DNA on our genome in many types of cancer where the DNA repair mechanisms are known to have been inactivated. In these cancer cells, mutations accumulate at a very fast rate, leading to more aberrant behavior. Also, individuals with defective DNA repair systems are more susceptible to developing various types of cancer.(4,5) Therefore, the first line of defense given to our cells against cancer is the ability to check and correct the integrity of our genome.

Every cell type in our body has been designed to proliferate at a certain rate that is suitable for the function of those cells. For example, neurons or muscle cells almost never divide after reaching adulthood, whereas the epithelial cells lining the interior of the intestines or under the skin divide at a fast rate continuously throughout our lives. The rate of division of a cell is mainly controlled by extra-cellular cues, i.e. a normal cell doesn’t grow or divide unless it receives growth and proliferation signals from neighboring cells.

There is a safe rate at which a cell must divide – just as a car needs to be driven at a safe speed. The requirement of cells for external stimuli in order to grow and divide is like the car’s need for someone to step on the gas pedal in order to accelerate. Normal cells cannot grow without control as neighboring cells produce growth signals when they are necessary and stop producing them in a regulated manner. A good example of the control of cell proliferation rate is seen in the wound healing process. When there is a cut in the skin, the cells adjacent to the wound are stimulated to divide rapidly by signals given from the injured cells; they divide and close the wound as soon as possible. However, when there are no wounds, there is no signal to divide and the skin cells only divide at a very slow rate, just enough to replace dying cells; this is a much slower process than wound healing. Cancer cells, on the other hand, are known to produce their own growth signals and proliferate abnormally fast and in an uncontrolled manner.(6) Therefore, the environmental control of cell division is an important barrier against cancer formation.

Cancer cells cannot divide uncontrollably unless they are independent of the external stimuli to divide. However, cancer cells can produce their own growth and proliferation signals, so they are free from external constraints. But even then, all is not yet lost. This situation of uncontrolled and rapid cellular proliferation is like a car in which the accelerator has become jammed– the car accelerates continuously and an accident is impending. In this situation the way to prevent too much speed is to step on the brake of the car. Similarly, in a cell, there are a set of genes called tumor-suppressor genes, which are responsible for stopping cell division upon excessive growth stimuli.(7) These genes act like brakes in cell division and prevent further progression into a malignant state. In many cancers,(8) it has been shown that these genes have been inactivated. If the brakes of the car are functional, you can safely bring your car to a stop and fix the problem that caused the accelerator to jam. Similarly, if a cell starts to divide too rapidly, it can stop dividing and repair the damage that caused the uncontrolled growth. Therefore, tumor suppressor genes represent a third line of defense.

If all the previous safety valves fail, there is one more defense to cancer. A situation in which a cell with harmful mutations promotes its own proliferation and cannot abort the division process is similar to one where the accelerator of the car is jammed and the brakes don’t work. In this case, in order to prevent greater damage, one can choose to hit a wall or a tree to stop the car– this will total the car, but will prevent further damage to others. Similarly, if a cell begins to grow uncontrollably and can’t slow down its rate of division, a process called apoptosis, or programmed cell death is initiated. In apoptosis, the cellular DNA and cellular compartments, like lysozomes, Endoplasmic Reticulum, and Golgi are degraded, and the cell shrinks in size. In the end, the cell dies and is absorbed by neighboring normal tissue. Therefore, the programmed death of an aberrantly behaving cell is another way that the body is protected from cancer. As expected, in cancer cells defects in this last line of defense are observed as well.(9)

These four mechanisms, i.e. DNA repair, external/ internal cell division suppression, and programmed cell death, are only the ones that we are aware of at this time. In addition to these, there are multiple levels of other redundant safety checks. All these safety features work without our knowledge or will. Findings from cancer research show that the design of cells was carried out so intelligently that even the carcinogenic environment which we produce today was accounted for within the genes of the very first human being.

Notes

1. Cancer Statistics 2006. 2006, American Cancer Society.

2. Vogelstein, B. and K.W. Kinzler, “The multistep nature of cancer.” Trends Genet, 1993. 9(4): p. 138-41.

3. Wogan, G.N., et al., “Environmental and chemical carcinogenesis.” Semin Cancer Biol, 2004. 14(6): p. 473-86.

4. Dixon, K. and E. Kopras, “Genetic alterations and DNA repair in human carcinogenesis.” Semin Cancer Biol, 2004. 14(6): p. 441-8.

5. Jiricny, J., “The multifaceted mismatch-repair system.” Nat Rev Mol Cell Biol, 2006. 7(5): p. 335-46.

6. Brattain, M.G., et al., “Growth factor balance and tumor progression.” Curr Opin Oncol, 1994. 6(1): p. 77-81.

7. Hanahan, D. and R.A. Weinberg, “The hallmarks of cancer.” Cell, 2000. 100(1): p. 57-70.

8. Coleman, W.B. and G.J. Tsongalis, “Molecular mechanisms of human carcinogenesis.” Exs, 2006(96): p. 321-49.

9. Dlamini, Z., Z. Mbita, and T. Ledwaba, “Can targeting apoptosis resolve the cancer saga?” Future Oncol, 2005. 1(3): p. 339-49.

Immunity can be divided into innate immunity and acquired immunity. The mechanisms of innate immunity are given to us by our Creator as a tool with which to protect ourselves. These are used to fight against every kind of microorganism. These ever-ready forces do not need to have met the enemy microorganisms to fight them off. Acquired immunity comes about after the infectious microbe has been encountered; this is usually as a result of infection or vaccination. Such immunities only protect the body against a specific harmful organism. T and B lymphocytes and antibodies belong in the acquired immune system, whereas other mechanisms are part of the innate immune system. We can classify the very intricate immunity mechanisms as follows:

A – Layers that cover the inner and outer surfaces of the body: These are the physical structures that carry out the task of protection by covering the tissues like a shield or fortress.

1. Skin: Our skin is an organ in its own right. It is created with such perfect characteristics that no microorganism can penetrate our body if there are no flaws, like gashes, scratches, or wounds.

2. Oral mucous membrane: If the epithelial layer covering the interior walls of our mouth is healthy, microorganisms cannot infiltrate the blood.

3. Areas around the sexual organs: The sexual organ in males is, even at birth, more protected than that of females. For female children, the epithelium covering the interior face of the organ turns into a multi-layered structure due to the impact of estrogen (sexuality hormone) that starts being secreted after adolescence. That multilayered structure blocks infections that can result from sexual intercourse. Female children before adolescence do not have estrogen, thus their genital organs have a thinner layer of epithelium and are more likely to be infected. This is why cleansing after urination should be done from the front to the back and the genital organs should not come into contact with feces. Our God of infinite mercy also gives girls a hymen in order to protect girls from germs.

B – Flora bacteria (beneficial bacteria): These do not serve as mechanical obstacles, but are assigned tasks. There are some bacteria that do not cause illnesses in the urine and in the proliferation canals, the skin, throat, intestines, and the eyes. Those beneficial bacteria located in our body work for us and hinder other infectious bacteria from settling in these zones. Those places are sterile in the body of a fetus; no beneficial bacteria exist there. Protector bacteria are positioned in those places right after the birth; this is a revelation of God’s infinite compassion. For instance, a baby’s first feces are sterile because there are no bacteria in his intestines. As time passes, a baby adopts protector bacteria through his mouth by nursing, from bottles, and pacifiers. Parents should be careful about the purity of pacifiers, feeding bottles, water, and additional nourishments, particularly in the first couple of months, until the bacteria flora have been established in an infant’s body. Otherwise, babies can easily suffer from diarrhea. God equipped beneficial bacteria with some special peculiarities to be able to deter other microorganisms from settling in the body. Here are some of these peculiarities:

1. They compete with infectious bacteria on the consumption of nutrients, so they restrain the reproduction of other bacteria.

2. They emit bactericides that kill only pathogenic (harmful and infectious) bacteria.

3. Some flora bacteria are assigned a mission to impede the reproduction of pathogenic bacteria so as to reduce pH (increase acidity) in the environment. For example, the lactobacillus in the female genital passage produces lactose by breaking down the glucose in the uterine canal in order to acidify the secreted matters in that canal. Reproduction of fungi is also obstructed in the same way. Due to that fact, some fungal diseases might emerge in genital areas or in the ears, among other places, after antibiotic treatment. Antibiotics kill not only pathogenic bacteria, but also flora bacteria. Thus, desultory usage of antibiotics should be avoided.

Today, beneficial intestinal bacteria are taken orally in capsules, and infectious bacteria in the intestines are killed by supplementing the flora bacteria in that organ without the use of antibiotics.

C – Mechanical cleansing:

1. Secretions:

a.Saliva: Secreted continuously from the glands behind the ears, beneath the chin and beneath the tongue, saliva expels the intruder pathogenic bacteria by cleansing our mouths. It also prevents tooth decay and gum inflammation by cleaning leftover food on which bacteria could feed.

b. Tears: Tears are charged with the duty of cleaning the conjunctiva (the mucous membrane that lines the inner surface of the eyelids and that continues over the forepart of the eyeball) and the cornea (the transparent part of the coat of the eyeball that covers the iris and pupil and admits light to the interior).

2.Cilia: These are feather-like cell extensions of microscopic size.

a.Nasal Cilia: Covering the nasal mucous membrane, mucus (a slimy substance) grasps dust particles and microbes in the air due to its adhesive nature. Lumpy folds inside the nose do not let the air flow straight. Therefore, a turbulent air current occurs in the nose. This turbulent current causes the particles in the air to come into contact with this slimy substance and to get stuck there. Epithelial cells also have cilia expanding toward the nasal cavity. Every cell has nearly 200 cilia. These cilia push mucus and the dust particles attached to it toward the pharynx with an up and down whipping action (10–20 strokes per second) so as to keep them away from the lungs.

b.Cilia in the lower respiratory passages: The upper surface of epithelium that is spread on the trachea, bronchi, and bronchioles is also covered with mucus. Epithelial cells in this area have cilia, too. These cilia do the same whipping action to push particles and microorganisms in the mucus toward the pharynx. They are pushed into the pharynx and expelled by coughing. One of the damaging impacts of nicotine on the respiratory system is that it paralyzes these cilia and disrupts the discharging process of harmful particles. As a consequence, smoking leads to many lung diseases.

D – Enzymes, acids and antibodies in body secretions:

1.Lysozyme: This is a substance found in body secretions (saliva, perspiration, tear, genital organ secretion etc.) that kills bacteria.

2.Stomach acid (Hydrochloric acid, HCl): Being emitted through stomach glands, HCl is a strong acid that can destroy bacteria that are able to reach as far as the stomach with the food we eat. Although we usually have our meals without cleaning our hands sufficiently or without washing them thoroughly, we rarely (except for situations where we are exposed to a high density of microbes like food poisoning or dirty drinking water) get infected via this route. The actors in this perfect protection are lysozyme and stomach acid.

3.Antibodies: Being present in the blood and body secretions, antibodies play a role in the defense against microorganisms. Antibodies in breast milk are passed from the mother’s blood to her milk via a very special mechanism, and are significant in the protection of an infant from infections.

E – Defender Cells: Resembling special operation forces, each of these cells is trained in different parts of the body and sent into the blood circulation. Those troop-like cells, which protect us against diseases by struggling fiercely with germs that can reach the blood after overcoming many obstacles, cannot have come about merely by chance, without the participation of the All-Knowing Designer.

1.Macrophages: Monocytes, a kind of leukocyte in the blood, pass from the capillaries to the tissue and turn into giant cells called macrophages that can phagocytose (swallow microbes) at a great rate. Macrophages swallow and tear down every kind of bacteria and virus that invades the body. These cells constitute the first defense line of the body and serve like advance guards. For instance, the first force to start fighting against the germs that can penetrate the skin through a scratch is the macrophages found just beneath the skin are called histiocytes. Germs that can infiltrate the blood through the intestines and reach the liver via the portal vein are eradicated by another type of macrophage. Therefore, almost no bacterium can pass from the intestines into the general blood circulation system. Germs that enter the body orally are destroyed by macrophages stationed in the lymph nodes on the tonsils. The ones that manage to reach the lungs through the respiratory paths are killed by the macrophages in the alveoli. Those cells also cause T-lymphocytes (very specially equipped cells) to proliferate by stimulating them. 2.Neutrophils: These are the most common type (60-70%) of leukocytes. These cells participate only in fights against bacteria. When bacteria enter a tissue, some poisonous matters emitted by them cause a chemical reaction called chemotaxis; this reaction attracts the neutrophils toward the infected tissue. In this case, the neutrophils leave their capillaries for the infected tissue and find and destroy the bacteria. How can germ-eating cells, like macrophages and neutrophils, distinguish normal body cells from microbes? Undoubtedly, the Creator of such an excellent defense system does not make us worry about such a problem; it was for this purpose that God created opsonins. Opsonins are similar to adapters in that they are able to attach two different parts together and connect themselves to a specific place on the germ. Thus, macrophages and neutrophils carry out their germ-eating job perfectly, connecting themselves to those opsonins. Since our own body cells do not have receptors that can handle opsonins, they cannot be eaten. 3.Lymphocytes: These are the troops of the immunity system with the most complicated organizations and strategies. These troops are categorized as T and B lymphocytes. They are the most important and powerful of the immunity mechanisms and constitute about 20-30% of the leukocytes in blood. They are regarded as the last defense line against those germs with which the other mechanisms cannot cope. a.T lymphocytes: When T lymphocytes are stimulated by macrophages, T cells that are a form of T lymphocyte secrete a matter called lymphokine. Lymphokine stimulates cytotoxic (microbe killer) T cells and B lymphocytes into action. Unless auxiliary T cells exist, the acquired immunity system collapses. Likewise, the HIV virus destroys auxiliary T cells and renders a person susceptible to disease. Even very simple infections can turn into a catastrophe for those patients. Cytotoxic T cells assault bacteria and particularly virus-infected body cells. They deliver porphyrins (proteins to make holes) into cell membranes by attaching themselves to the cells. In that way, a huge amount of water enters the cells and they get torn, due to over-swelling. Thus, viruses in the infected cells are dispersed and are neutralized by specific antibodies produced for that purpose with their infecting ability being impeded. (Viruses have to enter body cells to be able to proliferate. Only in this way can they protect themselves against antibodies and proliferate. Viruses that proliferate in cells use matters in those cells and cause them to eventually break apart, then move onto other cells.) b.B lymphocytes: These cells are stimulated directly by microbes. However, they need lymphokines to be completely stimulated and activated. Lymphokines are created capable of causing B lymphocytes to proliferate and transform themselves to Plasmocytes. Plasmocytes also emit antibodies to the blood. c.Killer cells: These play a role in the innate immune system, so they do not need stimulation like T and B lymphocytes. In particular, they assault body cells that are virus-infected or show a tendency to cancer. In this way, they establish a first defense line against viruses and block cancer development. Even though the working principles of lymphocytes are not known, they are related in some way to spiritual values such as love, enthusiasm, and peace of mind. Likewise, it is known that the immune systems of people whose spirituality has been weakened by depression and stress are more susceptible to break down. Unless those people recover by activating their spiritual dynamics, like faith in destiny, they are under a greater threat of cancer. Yet, this world is a place of examination. We cannot claim that every cancer is due to a damaged spirituality; we should not forget that cancer might occur due to different reasons. 4. Eosinophils: These are a kind of leukocytes that can kill some sort of parasites. They cling to parasites and release the granules in their cytoplasm into the parasites. These granules contain enzymes which destroy parasites. 5. Mast cells and basophils: Mast cells and basophils play a central role in inflammatory and immediate allergic reactions. They are able to release potent inflammatory mediators. Mast cells function out of the veins and protect the tissues in the body, whereas basophils are similar cells found in the bloodstream. F – Factors in plasma: 1.Antibodies: These are secreted into the blood by plasma cells. They fight against the germs that have stimulated them. They show their impact directly (neutralizing bacterial poisons, gathering and precipitating bacteria, neutralizing viruses, pulling microorganisms into pieces) or by activating a very special system called a complement. 2.Complement proteins: When inactive complement proteins in plasma are stimulated by antigens and an opposing antibody complex, active complement compounds are brought to life. These compounds have various effects like chemotaxis, opsonization, development of inflammation as a result of stimulation of mast cells and basophils, and the destruction of microorganisms. The complement system can be stimulated by microorganisms without a need for antibody development (without a need for lymphocytes); this can be seen as a manifestation of our Creator”s name Mudabbir (managing, administering, controlling every being in balance and order). This ensures the stimulation of a complement system under conditions that lack antibody production. Hence, the body is never left completely undefended. Is it really possible that such an amazing defense system, that requires unlimited knowledge and power, and that consists of every kind of alternative action, can come into existence by itself? 3.Interferons: Viruses invade body cells and synthesize proteins that contribute to their proliferation. Interferons, secreted by lymphocytes or other leukocytes, are created so that they can attach themselves to virus-infected body cells and obstruct the production of those proteins. Hence, these viruses cannot proliferate. 4.Lysozyme: Mentioned in the earlier part concerning body secretions, lysozyme is also available in the blood and kills bacteria there. 5.Properdin: This is a kind of protein available in the plasma which can neutralize viruses and destroy some bacteria types. 6.Acute phase proteins: These are a large number of serum proteins (C-reactive protein, etc.) that are swiftly synthesized by the liver and that are employed in defense during infections. 7.Beta-lysin: A substance that destroys some types of bacteria. G – Events caused by infections: 1. Inflammation: Inflammation is a response that is designed to protect tissues against tissue destruction, caused by factors like infection, excessive heat, and trauma. When a tissue is invaded by microorganisms, it starts to be destroyed; certain matters come out of those tissue cells (as mast cells) and lead to certain reactions in that zone. a.Vasodilation: As the little veins transporting blood to a tissue widen, more blood rushes in and more neutrophils are carried to that zone. Meanwhile, a color enhancement (blushing) occurs in that place. b.Increase in permeability of the capillaries: Neutrophils can penetrate into the tissues more easily. Plenty of water also passes through tissues, so some edemas (swelling in tissues) develop. Finally, coagulation proteins in the plasma, which can rarely infiltrate from capillaries to the tissues because of their large molecular structures, pass to the tissues and clot the liquid here. Hence, lymph veins, which are responsible for returning the liquid to the blood circulation, are plugged by clots. Consequently, inflammation detains microorganisms in that specific zone and prevents them from spreading throughout the body. Microorganisms are also destroyed by tissue macrophages in the inflammation zone and the migrant neutrophils working there. (The more a bacterium causes tissue damage, the harder it passes to blood.) Then, remnants of dead bacteria, damaged tissue cells, and neutrophils that are also destroyed after the phagocytosing of between 5 and 20 bacteria soften the inflammation by dissolving and creating some pus in that zone. The pus streams out by itself or is relieved by an incision being cut in the covering skin. 2. Fever:Toxins coming out of some bacteria and some secretions of microbe-phagocytosing cells lead to an increase in body temperature. Fever stops reproduction of microorganisms and kills them by ruining their structures. Within this framework, the occurrence of fever is beneficial; it indicates that the body is resisting and struggling to kill the microbes. Therefore, fever should not be reduced as long as it is not too high to cause brain damage (especially for children). 3. Cough: A cough helps the body discharge the microbes in the respiratory paths. Thus, cough medicines should not be used immediately, except in cases of whooping cough. 4. Diarrhea: This helps the body rid itself of feces quickly, so medicines to stop diarrhea should not be used, either. However, in cases of cough and diarrhea, a person should know their own strength and the strength of their immune system well and take medication accordingly. When we consider all these defense mechanisms, this question occurs in our minds: Do we protect ourselves against infections or is there someone who operates various immunity mechanisms in our bodies and controls them at every moment with His infinite knowledge and power?

Unpreparedness played an unquestionable role in this tragedy. Even if American officials had been sufficiently informed in advance about how the attacks would occur and that the targets were the World Trade Center, the Pentagon, and other sites, they would never have given the slightest credit to the idea that œAmerican pilots would launch a kamikaze attack from the air. Nor would they have increased all security measures in the area.

Take any strong country, none of which has a direct enemy. One type of enemy probably is not happy with a strong countrys policies. Another enemy would be participating in a counter-activity with a regional motivation. A third enemy would wage a direct attack on the strong country so that it would be top-listed on the global agenda. In addition, it would seek an opportunity to express its criticism to the world. A fourth enemy would organize acts of terror throughout the world in order to realize its short- and long-term political and other goals.

Terrorists aim to scare people, to obstruct the governments authorized arms, and to challenge the federal government in the political and military arenas. However, these reasons are not enough to explain what we are facing today. The modern world confronts more than ordinary internationalterrorism, for the terror we see today is new and has large dimensions. Its operational and philosophical characteristics are now under investigation.

Recently, American society has observed murders committed by students at schools, collective suicides of families, kidnappings, Timothy McVeighs Oklahoma bombing, mail bombs, poisoned letters, and so on. In my opinion, such activities cannot be coincidental and are not very favorable developments in this great country.

This most cruel and violent terrorist activity seems to have been planned to the smallest detail. Also, its perpetrators benefited from the methods of previous attacks: the psychological training of kamikaze pilots, how to hijack airplanes and use them like rockets, obtaining information about the air defense system and target weaknesses, and how the attacks would be directed were all carefully analyzed.

It is impossible to understand this tragic attack completely without a clear assessment of its perpetrators goals. Perhaps the driving motivation could be an emotional factor of punishing America for one of its acts or for being what it is today. This basic assumption was surely a significant incentive.

The perpetrators obviously wanted to create a shocking psychological effect on governmental officials as well as on the entire society, to defeat the opponents active defense power, to display international terrorism as if equipped with vast facilities, and especially to ensure that the American government changes its current policies. Another option also could be a type of adventure-seeking insanity or just a furious mob, both of which have found no place for themselves in this world but nevertheless wanted to draw the worlds attention to themselves.

Biological weapons (BWs), defined as infectious bacterial or viral agents used to harm others, have a long history2: Primitive peoples used arrows poisoned with biological toxins from animal and plant extracts, and also poisoned their enemy’s water supply with fecal extracts. Medieval warriors besieging the Russian city of Kaffa catapulted plague-infected corpses over its walls. Europeans knowingly gave smallpox- or measles-infected blankets to Native Americans, who had no resistance to these diseases. BWs reportedly were used during WWII. Over time, BWs have come to include biologically derived toxins and poisons.3 Among the most dangerous agents are smallpox, botalinum toxin (Btx), anthrax, and ricin.4 Some are highly lethal, while others incapacitate the host or primarily harm animals and plants. Today, many countries are believed to fund such research.

BWs Become a Modern Issue

Japan started the first offensive biological weapon program in 1918 with Unit 731, a special army unit dedicated to BWs production and experimentation. In 1931, it moved to Man-churia, China, where it conducted experiments on Chinese people and actually attacked several cities with different BWs until 1942. At least 10,000 Chinese died during those experiments. In 1942, the U.S. learned of this program and started its own. By 1969, it had weaponized the agents causing anthrax, botulism, tularemia, brucellosis, Venezuelan equine encephalitis, and Q fever.5

In 1969, President Nixon declared that the U.S. unilaterally renounced first use of lethal or incapacitating chemical agents and weapons, and unconditionally renounced all methods of biological warfare. Henceforth, the U.S.’s biological program would research only strictly defined measures of defense, such as immunization. All stockpiles were ordered to be destroyed. The U.S. and 165 other countries have signed the Biolog-ical and Toxic Weapons Convention (BWC), and 144 countries have ratified it.6

But the BWC cannot be effective if it cannot be enforced. For example, the USSR signed it but continued its programs. In 1979, at least 66 people died after an accidental anthrax release from a plant near Sverdlovsk. Soviet authorities denied any BWs production, but years later President Yeltsin confirmed that anthrax was being researched at that time.7 Yeltsin further asserted that all such programs were stopped and that stockpiles were being removed. However, evidence suggests that part of the offensive programs continue.8

The USSR’s demise (1991) led to the spread of BWs production information. According to Margolis, some of the 60,000 scientists and technicians formerly employed by its biological warfare establishment reportedly are working in Iraq, Israel, Iran, Syria, and Serbia, all of which already have extensive arsenals of biowarfare weapons. India also may have received substantial Russian aid.9

Iraq announced its BWs program in 1995. Fortunately, such agents were not used during the Gulf War, possibly due to fear of nuclear retaliation. The UN destroyed whatever it could find of Iraq’s BWs program in 1996.10 China, Iran, Taiwan, Syria, Cuba, North Korea, Egypt, Israel, and Libya are suspected of having similar programs.11

Why Would Anyone Use BWs?

In the eyes of nations or groups that put their own ideology or interests above all other considerations, including human life and future generations, such weapons might appear attractive. Consider the following points:

BWs probably are more effective on a per-quantity basis than more conventional weapons. Just 8 ounces of Type-A botalinum toxin, “the most lethal substance known,” could kill every living creature on Earth.12 One gram of anthrax contains 100 million lethal doses, and a few kilograms can kill as many people as died at Hiroshima.13 Generally speaking, several kilos of a biological agent can have the impact of several tons of nerve gas. BWs are extremely effective because they are highly toxic and are living organisms that multiply in and infect target hosts.

Producing chemical and nuclear weapons requires sophisticated equipment and highly trained personnel; BWs require only a modest level of education and investment. Kathleen C. Bailey, a former assistant director of the U.S. Arms Control and Disarmament Agency, is “absolutely convinced” that a major biological arsenal could be built with $10,000 worth of equipment in a 15×15 ft. room.14

For example:

To infect 1 sq. km., it would cost approximately $2,000 using conventional weapons, $800 using nuclear weapons, $600 using chemical weapons, and $1 using biological weapons. Any nation with a reasonably advanced pharmaceutical and medical industry can mass produce BWs.15

Weaponized anthrax probably could be produced in a small house, apartment or RV for less than $100,000. The program could be run by perhaps less than a dozen technicians with the equivalent of a BS degree led by one supervisor with a Ph.D. The relevant basic knowledge for most biological weapons-grade microbes is freely available, and equipment and chemicals can be obtained from dozens of suppliers.16

A live weapon needs only a small sample for mass production. Some agents exist naturally in the soil or can be ordered from a biotech company. Various researchers have claimed that Saddam Hussein used the latter method to acquire his original anthrax culture.17 BWs are hard are to detect in the production phase, for most bioweapons can be produced in hidden and/or mobile conditions.18 When detected, the place can be quickly cleaned and transformed into an ordinary pharmaceutical research or biology lab. Furthermore, such anti-terrorist sensor systems as metal detectors, x-ray machines, trained dogs, or neutron bombardment cannot detect BWs.19

Damage is confined to people (and possibly other living things), thus leaving infrastructure intact20; the sheer terror caused by such a threat21; ensuing governmental panic22; and the time lag between release and detection makes identification and apprehension very remote.23 But BWs also have certain drawbacks, among them:

The need for effective delivery. Most biological agents infect through inhalation. Too-large particles are caught in the respiratory system; too-small particles are exhaled. To stay in the lungs, the particle should be between 1 and 5 Angstroms. In fact, a BW attempt in Japan failed because the dissemination tool was ineffective.24

Even if disseminated, the desired result is far from certain. Most biological materials, including spores, are destroyed by exposure to ultraviolet light and drying. Agents released in the air may disperse in unexpected ways due to changes in wind patterns. Rain may wash the agents out of the air before they reach their target. Also, BWs can turn around and infect those who released them.

BWs’ live nature is a two-edged sword. The disease spreads easily, but no one can know when it is safe to live in the infected area. An agent’s lifespan is a major concern, for it can become part of the local microflora and thus threaten any military follow-up activities for an unknown length of time.25

Vulnerability to Attack

BWs have two main uses: on the battlefield and on a civilian population. Battlefield Use: BWs have several drawbacks here, such as high dependence upon external conditions, delayed effects, possible self-infection, uncertainty over when an infected area is safe enough to return to, and neutralization by vaccination or protective clothing. Use on a Civilian Population: This is the true horror, for civilians would not be prepared for such an attack and the resulting epidemic would be very hard to control. If the attack is covert, authorities would be unable to identify the source and unaware of the attack until infected people start showing up in the hospitals. When they finally identified the agent, the infection would be widespread. If a vaccine did not exist, health professionals would be unable to offer much help. The U.S. considers itself very vulnerable to such an attack and is working to protect itself.

Given that BWs are not hard to obtain, why have they not been used on civilian populations so far? The main reasons seem to be fear of a reprisal attack and of alienating the public to one’s cause. Potential users apparently feel that the disadvantages far outweigh the advantages. But as they may not always feel that way, the U.S. and other nations are studying how to prepare their national health care infrastructures and personnel to deal with such an event.

A Recent Development

On July 26, 2001, the Washington Post announced that the U.S. would withdraw from the BWC on the grounds that a newly proposed protocol “would not prevent cheating, and could encourage espionage against the U.S. pharmaceutical and chemical industries.” One wonders if other countries will follow suit.

Conclusion

Many Web sites discuss this vital issue, such as: www.brad.ac.uk/acad/sbtwc/: strengthening the BWC; www.cbiac.apgea.army.mil/about_us/general.html: Department of Defense focal point for data related to Chemical Warfare/Chemical and Biological Defense technology; www.asanltr.com/: specializes in nuclear, biological, and chemical defense and protection issues; www.geocities.com/nbclinks/: gateway for nuclear, biological, and chemical warfare data on the Web; and www.seanet.com/~gtate/cwoff.htm: gives access to various chemical warfare-related Web pages.

All religions condemn such horrific weapons on the grounds that all life is inherently sacred and worthy of respect. However, realpolitik, greed for profits, ideological conflict, and the need to assert or maintain control of natural and other resources deafens many governments and people to the appeals of religion.

Unfortunately, one nation’s and even one group’s decision to head down this path causes others to follow for the sake of self-preservation. We are well-advanced on this path, and no one can say where it will end

Footnotes

1. Rod Hafemeister, “Vaccines Will Not Suffice Fight Vs. Anthrax Needs Other Ammo,” Belleville News-Democrat (28 Dec. 1997). Online at: www.militaryreporter.org/anthrax.html.
2. R. E. Hurlbert, Microbiology 101, “Chapter XV, Adden-dum: Biological Weapons; Malignant Biology,” Washington State Univ. 1997). Online at: www.slic2.wsu.edu:82/hurlbert/micro101/pages/101biologicalweapons.html.
3. Henry E. Hardy, “Biological Weapons FAQ v. 0.44,” (1999): Online at: www.ocean.ic.net/ftp/doc/disaster/bio/biowfaq.html.
4. Partial online list: www.fas.org/nuke/intro/bw/agent.htm.
5. Thomas W. McGovern and George W. Christopher, Biological Warfare and Its Coetaneous Manifestations. Online at: www.telemedicine.org/BioWar/biologic.htm.
6. http://projects.sipri.se/cbw/docs/bw-btwc-mainpage.html.
7. F. A. Abramova et al., “Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979,” Proc Natl Acad Sci USA, no. 90 (1993): 2291-94; G. W. Christopher et al., “Biological Warfare: A Historical Perspective,” J Am Med Assoc, no. 278 (1997): 412-17.
8. Eric Margolis, “Another Doomsday Clock Is Ticking, Ticking,” Foreign Correspondent (20 June 1999). Online at: www.foreigncorrespondent.com/ archive/doomsday.htm.
9. R A. Zilinskas, “Iraq’s biological weapons: The past as future?” J Am Med Assoc, no. 278 (1997): 418-24.
10. Chemical and Biological Weapons Nonproliferation Project Web Page: www.stimson.org/cwc/bwissues.htm.
11. Margolis, “Another Doomsday,”(20 June 1999).
12. Robert H. Kupperman and David M. Smith, “Coping with Biological Terrorism,” in Brad Roberts, ed., Biological Weapons: Weapons of the Future? (Washington: Center for Strategic and International Studies, 1993), 35-46; Wayman C. Mullins, “An Overview and Analysis of Nuclear, Biological, and Chemical Terrorism: The Weapons, Strategies and Solutions to a Growing Problem,” American Journal of Criminal Justice 16:2 (1992): 95-119.
13. M. Asperilla, “Bioterrorism: The threat of the future.” Online at: www.sun-herald.com/2000/fron9.htm.
14. L. Cole, “The Specter of Biological Weapons,” Scientific American. Online at: www.sciam.com/1296issue/ 1296cole.html#1.
15. Ibid.
16. R. E. Hurlbert, “Biological Weapons: Black Biology,” Focus on Microbiology Education Newsletter (Spring 1998). Online at: www.microbelibrary.org/newsletter/nltrs98.htm.
17. For this and other claims of how the U.S. helped Iraq obtain the necessary ingredients for both biological and chemical weapons, consult Mark Phythian and Nikos Passas, Arming Iraq: How the U.S. and Britain Secretly Built Saddam’s War Machine (Northeastern Univ. Press: 1996); Alan Friedman, Spider’s Web: The Secret History of How the White House Illegally Armed Iraq (New York : Bantam Books, 1993).
18. Hurlbert, Microbiology 101 (see footnote 8).
19. Robert S. Root-Bernstein, “Infectious Terrorism,” Atlantic Monthly (May 1991): 44-50.
20. Stanley L. Wiener 1991. “Terrorist Use of Biological Weapons.” Terrorism 14:2, (1991): 129; “Chemical and Biological Weapons and Terrorism,” in Susan Flood, ed., International Terrorism: Policy Implications (Chicago: Office of International Criminal Justice, The University of Illinois at Chicago, 1991), 65.
21. Robert H. Kupperman and Darrell M. Trent, Terrorism: Threat, Reality, Response (Stanford, CA: Hoover Institution Press, 1979).
22. Harvey J. McGeorge, “Reversing the Trend on Terror,” Defense & Foreign Affairs 16:4 (April 1988): 16-22.
23. Jeffrey D. Simon, Terrorists and the Potential Use of Biological Weapons: A Discussion of Possibilities R/3771-AFMIC (Santa Monica, CA: RAND Corp., 1989): 10; William E. Burrows and Robert Windrem, Critical Mass: The Dangerous Race for Superweapons in a Fragmenting World (New York: 1994), 483.
24. The ease of dissemination remains controversial. A detailed summary of the BWs delivery scenarios can be found in Ron Perver, Chemical and Biological Terrorism: The Threat According to the Open Literature. Online at: www.csis-scrs.gc.ca/eng/miscdocs/purv_e.html#tab2.
25. Dr. Dane Jones. Online at: www.calpoly.edu/~drjones/ biowar-e3.html.