If we consider human nature as a book, the encoded information contained within, together with all the elements of inner and outer environments (bio-psycho-socio-cultural), becomes meaningful and functional. This is because each book has a visible structure composed of letters (semiotic DNA sequence) and a manifested meaning (semantic web) in a particular environment. From this point of view, genes should not be seen as mandatory codes, but should be considered as similar to the art of marbling (or ebru, which is the making of different patterns on a fluid by small vibrations of the ink droplets), for they are created by the united effect of various dynamic forces, and can only be understood accordingly. Human willpower and responsibility will also gain meaning and value when they are analyzed within the framework of the reaction intervals presented within the motifs of human nature which are shaped by the mutual effects genes and cultural factors have on each other. In this sense, human nature and culture should be evaluated together. We can organize the factors that determine human behavior and manners under three main titles – genetic, physicochemical environment, and psycho-socio-cultural factors. We can only speculate statistically as to how large or small a role each factor plays in development.

Behaviors like an inclination to crime, having intimate feelings for same sex individuals, cognitive and sensory sharpness, a desire for excitement and risk, or an inclination to addiction cannot be described by one or two genes. For instance, there are many factors (environment, genes) involved in acts of violence. However, one missing and insufficient factor can trigger violence. For instance, the Monoamine oxidase A enzyme is encoded by the MAO-A gene; this enzyme is in charge of degrading neurotransmitter molecules such as dopamine, serotonin, norepinephrine (these enable signaling between nerve cells). Depending on the mutations or polymorphisms of this gene, if the enzyme cannot function sufficiently, these individuals display an inclination towards violence and aggressive behavior. But if the person is aware of the situation and gets educational support from others, this behavior can be controlled.

Similarly, every person has a variable degree of genes that put them at risk for cancer. If these genes are activated via environmental factors – such as smoking, poor nutrition, mutagens, carcinogens – cancer may develop. On the other hand, if a person is lacking the cancer-causing genes or has low inclination towards cancer, such a person may not get cancer, even if he or she is a smoker. Similar statements can be made for genes associated with addictions, sexual perversions, and violent tendencies. More significantly, we can produce more value and meaning out of behavior-related genes when we evaluate them according to their context, position, and other factors, along with their relations to other genes. That is to say, there is a complicated network of factors that shape behavior. That’s why a DNA sequence alone cannot determine, all by itself, the development of emotions and manners, skills, and personality. In other words, phenotype can never be predicted 100% just by the interpretation of genetic information.

Brain and personality development is a multi-faceted, exposome mystery. From the start of pregnancy, especially throughout the preschool era, everything one is exposed to, and the way those events shape one’s nature, is called exposome. This can include subconscious events, for all sorts of personal history plays a role in such development. The connections of 1011 neuron cells that exist in an average human brain are not only determined by genes. Human DNA contains 6.2 x 109 nucleotide (letter), or information. Reading and using this raw information depends on many factors. Neurons can establish new connections via internal and external stimuli, while on the other hand, the number of neuron cells and connection networks can be changed by the neurochemical substances and hormones that they synthesize. All of the information required to define fine details in the motifs and connections of brain cells is not present in the genome. Mere environmental factors are not enough to complement this missing information.

Aside from these, many factors play a role in brain development and function. When the ends of axons and dendrites extend, they do so by recognizing nanomolecules that guide them all the way to the target organ or region. They happen to make minor changes and deviations during this extension. These changes are extreme enough that this extension is part deterministic and part trial and error. They reach the target through a statistically systemic algorithm but with a certainty less than 100%. Axons that are extended from eyes to the brain have a 1% possibility of taking a wrong turn at optic chiasm, and therefore not reaching the brain or arriving at the wrong region of it. However, there are also signalization systems built in our brains that recognize and correct these errors. If axons cannot receive the correct signals from target neurons, they get degraded. And sometimes a neuron of the axon terminates itself. These observations clearly show that brain development does not take place by a molecular program that is predetermined down to the minutest details but rather through a flexible program open to changes and errors.

This flexible program is explained by materialistic philosophy as “chance,” which basically means being in the right place at the right time to encounter the right factors. The same program, in religious literature, is explained by factors known as fate, kismet, destiny, divine blessing, and grant. Aside from that, there are also certain uncontrollable activations and a genetic background in the brain that are involved before we start a conscious action. From this perspective, motifs generated by biological and genetic inclinations set the infrastructure for the freedom of decision making and self-determination. Since our thoughts, emotions, and acts are formed within the neurogenetic and neurochemical construct of the brain, the motif that is created by the background here generates inclinations for specific acts and behaviors. In other words, events that take place in our brain chemistry during the fetal period and early childhood years are significant determinants of human development. The human brain can function in a state with willpower and consciousness, but can also function automatically, without consciousness. Briefly, it is through our genes that the framework of what we can achieve, our reaction intervals and threshold values are determined, and the possibility of an act is indicated. But the boundaries of the final decision are determined via statistical possibilities as a result of a person’s interaction with their environment. Therefore the boundary is not determined in a mandatory fashion, but via external dynamics (like manners, beliefs, or moral nourishment).

Human willpower is our capacity and strength to make free decisions and selections under the effects of spiritual, genetic, and environmental frameworks (endophenotype). The decisions and selections cannot take place independently from the sources nourishing one’s metaphysical world, cultural circles, or from the impact of neurochemicals in the brain and our hormones. “God burdens no soul except within its capacity” (2:286) is a sign of mercy and compassion from the Qur’an, indicating that the field of action and boundaries of the human willpower are determined based on multiple factors and wise causes. Producing customized religious rulings according to one’s natural strengths and weaknesses is also a very meaningful legal action in Islamic law. It is, in a sense, an acknowledgement that everyone has trials and experiences that are different than others’.

Humans have responsibilities within defined, limited conditions, and they can only make decisions within those permissible intervals of conditions and the constraints of their natural dispositions. If we can analyze human actions in a model that looks into their dispositions, cultural environments, genetic inclinations, and spiritual and moral nourishment, then we can attain better results in the education and character development of human beings.

Each factor mentioned above affects the child’s sexual separation and differentiation to various degrees. Misbehaviors during sexual development may emerge as a result of a complex mosaic of biological, psychological, sociocultural factors. There is not a complete consensus around the main reasons for this, yet each researcher favors one factor in the light of their expertise and ideological choices. However, objective observations and research point out that the quality of relationship between the parents and children is very influential in this matter. The display of unhealthy sexual inclinations stems from a negative background where there is not enough parent-child relationships to help the child develop. In families of children with strange sexual behaviors, a suppressive, excessively controlling model of mother and a distant, aggressive model of a father who resorts to violence are often found to exist. That is why many problems with intimacy and sex that occur later in life can be viewed as a developmental ailment and a problem of insufficient parental communication rather than a mandatory genetic phenomenon.

Various problems can arise when healthy differentiation and separation do not take place during a child’s development. A child, in the beginning, is like a part of the mother. If differentiated by detachment from the mother, and from her compassion and care, a child struggles to develop a healthy sense of ego. Such a child becomes inclined to develop a personality that is dependent, passive, and lacking sufficient confidence.

Research clearly states that each child is born with different inclinations and threshold values that are determined genetically and hormonally for each of his or her possible characters and behaviors. These potential inclinations and threshold values can surface depending on internal and external stimuli and educational styles. Even though both genders carry hormones belonging to each other naturally, during development one steps forward upon expression of encoded gender genes. When it comes to displaying sexual abnormalities, everybody is, genetically speaking, a dry log or a wet log. A dry log can easily catch fire, a wet one does not. However, it is the responsibility of society and parents to provide a spark-free environment for the dry log. Spiritual and biological nourishment during the developmental process are found to be significantly influential in diseases and aging, in disorders of character development, and in anomalies in sexual behaviors. When proper measures are taken timely, via suitable environments and educational modes, the possible surfacing of behavioral pathologies may be prevented or reduced for children potentially at risk. Through correct guidance and education, the expression and regulation of genes can be altered and managed, controlling these naturally present inclinations.

Cezmi Aydin is a freelance writer in natural sciences.

References

• Alper, Joseph S. (1998). “Genes, free will, and criminal responsibility.” Soc. Sci. Med. Vol. 46, No. 12, pp. 1599 1611
• Meyer, Lia Midori Nascimento, Gilberto Cafezeiro Bomfim, Charbel Nino El-Hani. 2011. “How to Understand the Gene in the Twenty-First Century?” Sci & Educ. DOI 10.1007/s11191-011-9390-z
• Levitt, Mairi and Neil Manson. 2007. “My Genes Made Me Do It? The Implications of Behavioural Genetics for Responsibility and Blame.” Health Care Anal. 15, pp. 33–40.
• Richardson, Brian. 2011. “What’s wrong with me? Coming to terms with same sex attraction.” Nursing Children 24 and Young People. October 2011. Volume 23. Number 8. pp. 22-24.
• William J. Jenkins. 2010. “Can Anyone Tell Me Why I’m Gay? What Research Suggests Regarding The Origins of Sexual Orientation.” North American Journal of Psychology, 2010, Vol. 12, No. 2. pp. 279-296.
• Botz-Bornstein, Thorsten. 2010. “Genes, memes, and the Chinese concept of wen: toward a nature/culture model of genetics.” Philosophy East & West Vol. 60, No. 2. April 2010. University of Hawaii Press, pp. 167–186.

As this news spread throughout the world, people began to ask if one day a human being could be cloned. Certainly, at least in theory, it seemed possible. Some people even claimed that it would be a good idea to clone such geniuses as Einstein and others who had passed away. On the other hand, others argued that such knowledge could lead to cloning such people as Hitler, and that this was reason enough never to open the door to this potentially dangerous technology. 

The role of environment

But is DNA everything? Is DNA the only item that makes us human? Case studies of same egg twins’ show that there is more to us than DNA. Researchers have noticed that such twins, despite having the same DNA and being brought up mainly in the same environment and the same manner, somehow follow different paths, acquire unique personalities, and show evidence of different characteristics, although they may show similarities during childhood. Thus we can see that environment is an important factor on human behavior.

Used in this context, environment refers to the surrounding society, culture, belief, and moral values in other words, that which separates human beings from animals. DNA, the acronym used for a person’s genetic code, plays the key role in the beginning of any biological life form. This key molecule functions similarly in both animals and plants to produce living cells.

Human beings have a special life-giving feature: the soul. Although its nature remains a mystery, its existence is felt deeply in the conscience and gives us a distinct nature that is not shared by non-human life forms. Although a person’s first biological body is evident in the DNA even before it assumes an identity, it is the soul that determines his or her character and temper. Another shaping factor that should not be underestimated is the surrounding society (e.g., family, school, and economy) that unites with the soul and contours the body.

The era in which one lives also has a role in determining one’s character. Given that a society is made up of individuals, it is subject to changes in moral values over time. Thus it is quite likely that if Einstein or Hitler were cloned, the resulting person would be an ordinary contemporary man who is obsessed with sports cars and the Internet, and a man who carries his cellular phone wherever he goes.

What made Hitler a monster was the era and society in which he lived, not his genes. What made Einstein a genius was the chance to explore and use his own capabilities and intelligence. It is quite certain that genes are the sole parameters that affect a person’s intelligence and other intellectual features. In addition, the wonderful and unknown nature of a human being would be more conclusive and understandable if the complex interactions between the spiritual properties and cultural effects were taken together as a whole.

The role of the soul

People can be cloned. In fact, clones that are biologically similar and yet behaviorally unique would be the best proof of the soul’s existence. Since the soul cannot be cloned, as it issues from a different world, cloning a person’s body may not be that dangerous. But it also would not make any sense. Moreover, the cloned individual could end up as a dangerous animal.

Consider the following example of inter-species breeding: When a horse and a donkey are mated, the resulting animal is a non-fertile hybrid. If a female horse and a male donkey are mated, the result is a non-fertile mule. If a male horse and a female donkey are mated, the result is a smaller and weaker animala hinny. But since half of the DNA comes from each animal and thus each hybrid offspring has the same DNA, how can this difference be explained? Obviously, the DNA contained within the mitochondria of the female horse’s egg cell makes a huge difference.

Other issues

The patent dilemma: The patent (copyright) system prevents any illegal copying and imitating and ensures that the actual researcher and inventor is rewarded. Drugs and chemical substances are the most patented items in medicine. After a large portion of the human DNA puzzle was solved, the issue of how to patent this information was put on the American agenda.

President Clinton declared that most parts of human DNA had been determined. However, such information was not to be placed in the hands of humanity at large, for the pharmaceutical companies had spent vast sums of money to produce this information. Also, it would be a serious violation of basic commercial sense for the companies to just give this information to the general public for free.

In addition, paying for the copyrights to acquire the technology does not mean that you are totally free to with it what you want, for these same copyrights limit the usage of that particular technology. This means that if cures are found for AIDS, cancer, and other currently incurable diseases, only the wealthy will be able to afford them.

Determining does not mean understanding: DNA consists of exons and introns. Exons form the meaningful parts of DNA by uniting with each other. We call the result genes. Introns are the non-meaningful parts of DNA. What is interesting here is that these non-meaningful introns make up 97 percent of all DNA. One wonders if they have functions, other than protecting and shielding the meaningful parts from external radiation and ultraviolet light, that are unknown to contemporary scientists? For example, each human cell contains about 4 meters of DNA chain in its nucleus. Surprisingly, introns and exons are represented by the same symbolic letters (A, C, G, and T), so determining the DNA chain is nothing more than a new beginning. The more important task is to identify the genes made of exons, which are non-trivially embedded into the introns.

The exact number of human genes remains unknown. According to some scientists, this number is either 25,000 or 32,000. Determining the DNA chain written with a four-letter alphabet is like trying to determine the meaning of an ancient inscription. Just seeing what it looks like does not mean that one can read it, for the latter is far more difficult than the former. This suggests that just determining the DNA chain is not enough, and that truly understanding the genes and their exact locations requires more time.

Conclusion

Human DNA has been determined, but we must remember that there are as many combinations as there are people. Also, the claim that DNA has been determined’ is true only for a select group of people. Human DNA differs from race to race, society to society, and even from disease to disease. Thus it will take more time to develop a full comparative table of human DNA. It would be great if our current technology somehow could devise a single formula to represent the gene map of every individual.

References

• Anderson, Kenneth N. (ed.), Lois E. Anderson (ed.), and Walter D. Glanze. Mosby’s Medical Dictionary. 5th ed. Mosby Year Book, Inc.: 1997.
• Erturk, Hikmet, DNA Her Sey mi?’ Siziniti, no. 269 (June 2001): 228-29. Translated by Emrah Altunkaya.