The Forgotten History of Sleeping in Two Shifts

Zaria Gorvett. The forgotten medieval habit of ‘two sleeps’. BBC, January 2022

For much of human history, people didn’t sleep through the night in one long stretch. Instead, they slept in two parts: an early “first sleep,” followed by a quiet period of wakefulness around midnight, and then a second sleep until morning. This pattern was so common that people once referred to it casually in court records, letters, and literature.

Historian Roger Ekirch uncovered this forgotten habit while studying life before the Industrial Revolution. He found that the time between sleeps, often called “the watch,” was used for prayer, conversation, chores, or simply reflection. People didn’t see this midnight waking as a problem; it was a normal part of nightly life.

The two-sleep pattern likely existed because nights were long and dark before artificial lighting. People went to bed earlier and woke naturally in the middle of the night. Modern experiments show that when people live without electric light, their sleep often returns to this older rhythm on its own.

Biphasic sleep began to disappear in the 19th century as gas lamps, electric lights, and factory schedules pushed bedtimes later while mornings stayed the same. Sleep became compressed into a single block, and the old pattern faded from memory. Understanding this history may help explain why waking up at night doesn’t always mean something is wrong. For most of human history, it was simply how people slept.

How Our Neighborhoods Shape Our Health

Noaeen, M., Rostami, A., Ghanem, I. et al. Mapping neighbourhood-level drivers of type 2 diabetes for precision public health using predictive and causal machine learning. Sci Rep, January 2026.

Type 2 diabetes is often discussed as a disease of individual lifestyle (diet, exercise, and genetics). But a new study from the University of Toronto reveals a deeper truth: where you live may be just as important as how you live.

Using artificial intelligence and advanced causal modeling, researchers analyzed data from over 1,100 neighborhoods across the Greater Toronto Area. Instead of focusing on individuals, they examined neighborhood-level features such as obesity rates, physical activity, income, age structure, mental health, and work stress. Their goal was not only to predict where diabetes is most common, but also to understand which factors actually drive that risk.

The results were striking. The AI models were able to identify high-diabetes neighborhoods with more than 95% accuracy. The strongest predictors were familiar – high obesity, physical inactivity, and older populations, but the causal analysis uncovered something more surprising: mental health was one of the most powerful protective factors. Neighborhoods with better average mental well-being had substantially lower diabetes rates, even after accounting for income, age, and lifestyle.

Work stress and smoking, on the other hand, were found to raise diabetes risk, highlighting the biological toll of chronic psychological strain. Interestingly, neighborhoods with higher proportions of recent immigrants and visible minorities tended to have lower diabetes prevalence, reflecting the well-known “healthy immigrant effect” and the protective role of social cohesion and cultural practices.

The study suggests a new vision for public health: instead of treating diabetes only in clinics, we should also treat it in communities, through mental-health support, stress reduction, walkable streets, and social infrastructure. In the age of data science, healing may begin not just with the patient, but with the neighborhood.

The Hidden Effects of Living in Space

Wijdan Al-Ahmadi et al., Spaceflight alters molecular networks linked to diverse human diseases in a single cellular model. Sci Adv, January 2026.

When astronauts return from space, many report strange changes. Their hearts beat differently. Their sleep is disturbed. Their vision becomes blurry. Their muscles weaken. For years, scientists have known about these effects, but not fully understood why they happen. A new study gives us a powerful clue by showing what happens inside human cells when they are exposed to space.

In this study, researchers sent human immune cells to the International Space Station and compared them with the same cells grown on Earth. They then examined how thousands of genes behaved in each environment. Nearly one third of all active genes changed their activity in space. This shows that spaceflight does not just cause small damage. It reshapes the way cells function.

Some of the biggest changes were seen in genes linked to the heart and muscles. These genes help control the electrical signals that keep the heart beating normally. In space, they became much more active. On Earth, the same genes are linked to irregular heartbeats, which may help explain why astronauts sometimes develop heart problems during long missions.

The study also found changes in genes that control sleep and the body clock, including those linked to melatonin. This matches the sleep problems many astronauts experience. Genes involved in vision and other senses were also affected, especially those connected to vitamin A and eyesight, helping explain vision changes in space. At the same time, genes that repair damaged DNA were reduced, likely because of cosmic radiation, making cells more vulnerable to long term damage.

These findings suggest that space activates the same biological pathways that cause heart disease, nerve problems, and aging on Earth, but in a much shorter time. By studying life in orbit, scientists may learn not only how to protect astronauts, but also how to better understand illness here on Earth.

Cell-based therapy may be used to treat obesity and diabetes

Wang CH et al. CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science Translational Medicine, August 2020.

Obesity is the main cause of type 2 diabetes and related chronic diseases that will be the cause of death for more people across the globe this year than Covid-19. Scientists recently have developed a proof of concept for a novel cell-based therapy against obesity. The potential therapy for obesity would transplant HUMBLE (human brown-like) fat cells, or human white fat cells that have been genetically modified to become similar to heat-generating brown fat cells.

Brown fat cells burn energy, instead of storing energy, as white fat cells do. In this process, brown fat can lower excessive levels of glucose and lipids in the blood that are linked to metabolic diseases such as diabetes. However, people who are overweight or obese tend to have less of this beneficial brown fat. The transformed HUMBLE cells are expected to overcome this problem.

The research team first generated HUMBLE cells from white preadipocytes and then used a variant of the CRISPR-Cas9 genome editing system to stimulate the expression of a gene called UCP1, which can transform white preadipocytes into fat brown cells. When these HUMBLE cells were transplanted into mice, they then remarkably functioned as the mice’s own brown fat cells. On a high-fat diet, the mice that received HUMBLE cells showed a much higher sensitivity to insulin and the ability to eliminate glucose from the blood than the mice in the control group. They also gained less weight. These results from animal studies are very encouraging for researchers. The hope is to generate HUMBLE brown cells for individual patients soon. Such a procedure would involve taking a small number of white preadipocytes from a patient, isolating the precursor cells, modifying these cells to stimulate UCP1 expression, and then re-transplanting the resulting HUMBLE cells to the patient. However, one foreseeable challenge is that this individualized approach can be very complicated and costly. An alternative solution could be to use unadapted cells, which would then be encapsulated with biomaterials that protect the cells from being rejected by the patient’s immune system.

The other option would be to apply gene therapy approaches that directly express the UCP1 gene in white fat progenitor cells in the body so that those cells acquire HUMBLE-like properties. Employing cell-based, or gene, therapies to treat obesity or diabetes used to be science fiction. Now scientific advances, such as CRISPR gene-editing technologies, will help us to improve the metabolism, body weight, quality of life and overall health of people with obesity and diabetes.

Even fake smiling can trick the brain to be positive

Ramos FM et al. Your Face and Moves Seem Happier When I Smile. Experimental Psychology, May 2020

Can a smile truly make everything better? Is there a scientific backing to this claim? A new study shows that even if you do not feel like smiling, faking one can have positive impacts. These findings could not be more timely with the world in crisis amid the Covid-19 pandemic, which is causing disturbing spikes in anxiety and depression cases globally. The study examined participants that held a pen between their teeth, forcing their faces to use the same muscles as a smile. The results showed that facial muscular activity not only alters the recognition of facial expressions but also bodily expressions, with both generating more positive emotions. Forcefully practicing smiling stimulates the amygdala, the emotional center of the brain, which releases neurotransmitters to encourage an emotionally positive state. For mental health, this study has interesting implications. If we can trick our brains into perceiving stimuli as “happy,” then we can potentially use this mechanism to help boost our mental health. These findings suggest that there is a strong link between action and perception. Perceptual and motor systems work together when we emotionally process stimuli. A “fake it ’til you make it” approach could be more realistic than people think.

FOMO impacts people of all ages

Barry CT et al. Fear of missing out (FoMO): A generational phenomenon or an individual difference? Journal of Social and Personal Relationships, August 2020.

In the last few years, the phenomenon of FOMO (Fear of Missing Out), has afflicted many of us at one point or another. In the age of social media, we may find ourselves making comparisons to our friends, family, or even celebrities. What others have, or what they are doing that we are not, may make us feel negatively about ourselves. This can lead to anxiety, sadness, jealousy, or anger. A new study showed that FOMO, once thought to be a teenager or young adult problem, can actually have an impact on anyone irrespective of their age.

Scientists conducted a survey of more than 400 people across the United States from ages 14 to 47 and asked a range of questions related to self-perception, life satisfaction, and social media use. Experts were expecting FOMO to be higher among younger groups since teens experience so much social development in such a short space of time, but the results showed a more uniform distribution across all ages. Moreover, they suspected social media to play a large factor in FOMO but quickly found that it was not a good predictor of the condition. For instance, two people with the same social media engagement may be affected quite differently: one might feel bad seeing their friend’s activities while the other might find it upsetting. Instead, social media was found to amplify those anxieties in people that already felt as though they were missing out. Finally, it was neither their age nor social media usage but rather self-perception that shaped to what degree FOMO affected the participants Researchers say that loneliness, low self-esteem, and low self-compassion may substantially contribute to feelings of anxiety. The study concludes that one major solution to FOMO-driven anxiety would be limiting your social media usage or even cutting it off for a time. Additionally, reaching out to professionals to get support to address negative self-perceptions, perhaps by contextualizing “faults” or “flaws” as challenges to overcome.

Diabetes is one of the most serious public health risks today. The United Nations declared diabetes as a global threat in 2007 in order to highlight just how widespread and destructive diabetes had become.

Diabetes is one of the oldest known diseases, and was even mentioned in the ancient Egyptian, Indian, and Chinese texts. Ancient Egyptian texts defined diabetics as “… so thirsty that if they drank all the water of the Nile, their thirst would still not be quenched.” The ancient Indian and Chinese texts mention insects and flies swarming over the urine discharged by the diabetics.

Ancient scientists Al-Razi and Ibn Sina (Avicenna) made important findings about diabetes. Al-Razi linked diabetes with obesity and nutrition habits. Ibn Sina specified that no tissues or organs could survive diabetes, which additionally caused sexual dysfunctions and gangrenes.

There are two main problems that emerge in relation to diabetes:

• Type 1: Lack of adequate secretion of the insulin hormones from the pancreas
• Type 2: Non-functional and insulin-resistant tissues, regardless of adequate insulin secretion

These two types do not coexist in one patient. The first occurs mostly among children or young people. The second occurs mostly among the elderly who largely contract diabetes due to obesity. Diabetes can be detected by a surge of sugar in the blood and urine. If blood sugar exceeds a certain limit then sugar will appear in urine.

Diabetes reveals itself by a surge of sugar in the blood and the urine. It not only impairs the sugar balance of the body, but also disrupts the fat and protein metabolism. Cells fail to absorb sugar, fats, and amino acids, which in turn increases sugar, fat, and amino acid levels in the bloodstream. It can plainly be said that diabetes complications originate from an increase in fat levels, not sugar levels, in the blood. Additionally, diabetic disorders in fat metabolism cause the lethal appearance of acid levels in the blood (acidosis) and vascular stiffness (arteriosclerosis). Decrease in protein-synthesis ability among patients with long-term diabetes leads to depletion of tissues and multiple cellular dysfunctions. Consequently, diabetes originating from insulin deficiency disrupts the fat and protein metabolism along with the sugar metabolism.

The pancreatic gland is where insulin is released in our body. The surgical removal of this gland in experimental animals showed that fat levels in their bloodstreams increased faster than sugar levels. In diabetics, fat around the abdomen and hips oozes into the bloodstream, thus leading to an increase in neutral fat (triglyceride) and cholesterol levels in the blood along with an accumulation of fat in the liver.

If fats remain in the bloodstream after nutrition, then they begin to adhere to vein walls which can cause clogging and stiffness in blood vessels. That is why it is crucial to transfer fat from the bloodstream to fat storage around the abdomen and hips by means of sugar and insulin. The storage fat is called neutral oil, or triglyceride. A triglyceride molecule contains three units of oil and one unit of sugar. Therefore, almost 25% of the fat storage is sugar. Without sugar supply from bloodstream, as in the case of diabetes, the cells which by default store fat are unable to do so. Diabetes, as a serious disorder, even reverses this mechanism: fats start moving from the storage to the bloodstream, not from the bloodstream to the storage. This causes the surge of all fats including the triglycerides, cholesterol and phospholipids, and this is when the body becomes even more prone to disease.

Obesity or excessively fat-based (steatopygic) diet is one of the main causes of diabetes. People are already overweight before the disorder strikes. However, if they do not receive treatment after contracting diabetes, the diabetics start losing weight quickly and more than they should. This happens because relatively harmless fats in storage start to dissolve into the bloodstream.

The entity called metabolic acidosis, which can cause coma and death in diabetics, actually originates from the surge of fat products in the blood and the liver, not from the surge in blood sugar. In diabetics, when the cells cannot use sugar, they resort to obtaining their energy from fats. Consequently, stored fats start to dissolve and ooze into the bloodstream. Fats traveling to the liver through the bloodstream turn into acidic substances called ketone bodies (acetoacetic acid, beta hydroxy butyric acid, and acetone). These acidic substances pass from the liver to the bloodstream and are received by the cells to meet their energy needs. However, in diabetics, cells cannot convert these acidic fat products i.e. ketone bodies, into energy. Oxaloacetic acid from sugars is required for the energy production cycle called the Krebs cycle. In short, humans need sugar to burn fat. This is why it is normal for some people to feel the need to eat something sweet after a fatty meal, because they need sugar to dissolve the fats in their bloodstreams. Since the cells cannot draw sugar from the blood, they suffer from the deficiency of oxaloacetic acid to convert fats into energy. Fats and ketone bodies teem in the bloodstream and, since ketone bodies are acidic, they can cause acidity levels to surge to extremely high levels in the bloodstream which can result in a coma or even sudden death. The lethal substances here are not sugars but ketone bodies, or fat products.

The most crucial abnormality caused by diabetes is vascular stiffness (arteriosclerosis), which originates not from excess sugar but excess fat in the bloodstream. In diabetics, triglyceride, cholesterol, and phospholipid levels increase in the bloodstream due to the reasons described earlier. Fats in the bloodstream do not circulate freely; they are carried in micro-droplets called lipoprotein. The liver loads the fats onto lipoprotein “trucks” and sets them into the bloodstream to be used by the cells. However, due to insulin deficiency in diabetics, lipoproteins cannot empty their shipments of fat into fat storages. The most dangerous lipoproteins for vascular stiffness are classified as LDL (low-density lipoprotein) and HDL (high-density lipoprotein) types. HDLs are like empty trucks specially produced by the liver, which dispatches them into the bloodstream. While circulating in the bloodstream, these “trucks” collect the fat and cholesterol stuck on the vein walls like magnets and, after cleaning the inner vein walls, they return as loaded trucks back to the liver. Using the HDL “trucks,” the liver removes fat from the bloodstream. Physicians gauge the LDL and HDL levels while checking their patients for the risk of vascular stiffness. An increase or decrease in LDL rate is not good for patients, whereas high HDL rate is a positive sign.

Other causes of vascular stiffness include lack of exercise, sedentary life and work habits, smoking, alcohol consumption, obesity, overconsuming foods rich in animal fat, and high blood pressure. Vascular stiffness is one of the leading causes of cardiac dilatation (enlarged heart), cardiac insufficiency (heart failure), and heart attack. In addition to these complications, vascular stiffness may also lead to high blood pressure, cerebral hemorrhage, paralysis, kidney failure, and vascular occlusion in the brain or other organs. If not treated, almost all of these disorders result in death.

Diabetics should follow an effective treatment regime to keep their blood sugar level under control. Fasting is known to be beneficial for controlling blood sugar. If blood sugar is normal, the fats in the bloodstream will move to the storage and not damage the blood vessels. Among the elderly and the obese diabetics, any damage originating from high blood sugar does not surface immediately, and this may mislead patients. It is extremely crucial to check blood sugar in order not to fall into this error. Treatment should never be neglected. If blood sugar can be effectively reduced, it is not right to give up sugar completely in the diet. As mentioned earlier, humans need sugar for storing fats or converting fats (or ketones) into energy in the Krebs cycle.

In short, high blood fat is a more serious cause of diabetes than high blood sugar.

The Coronavirus pandemic has swept the world in recent months and with it came a wave of panic, unease, and a need for courage. Humanity is collectively fighting for its health, a treasure that we sometimes take for granted. It is imperative that we constantly look to maintain our health through reviewing potentially harmful practices and working to discover new methods of cleanliness and purity. Many of our articles in this issue will explore the theme of health across the spectrum including bodily, psychological, spiritual, and moral health. We also discuss Coronavirus in detail in this issue’s Science Square and dispel some conspiracy theories that the virus is man-made.

Washing our hands regularly is actually one of the most simple and effective ways to help prevent the spread of viruses, including Covid-19. Such a simple procedure seems like common sense nowadays, but this process was actually a breakthrough in the nineteenth century. Consistent hand washing and sterilization is especially important for hospital staff as they can easily transmit new diseases and germs into patients with weakened immune systems. Taking responsibility for our individual health will contribute to the overall health of our society by at least not spreading disease.

Diabetes is another disease that threatens the well-being of millions across the globe. It is complicated, and we explore in this issue the differences that excessive fat and sugar consumption can have in regards to causing and accelerating diabetes. We can best preserve our health with reasonably sized diets that are rich in nutrients, and routines that physical exercise.  

The effects of selfishness versus selflessness on the mind are also explored. It is no secret that many current societies promote selfishness over the well-being of others whether through subliminal advertisement messaging or the consistent emphasis placed upon trampling over others for career success. The way that we view and treat others, whether positively or negatively, has a rippling effect throughout society and works to either bolster or deteriorate our collective mental health and happiness.

We must especially work hard to preserve the health of our children, from the food that they eat to the media and technology that they use. Cell phone usage among infants and toddlers is becoming more and more widespread, however studies have shown that excessive usage can stunt their growth or even permanently alter their very fragile and rapidly developing brains.

Our world is rapidly changing, as it seems that every year produces new innovations and challenges to keep up with. It is up to us to stay informed and aware, lest we fall behind and fail to preserve the very things that we hold most dear.

Life is in the center of existence, and food is in the center of life. All living things are in pursuit of their sustenance to continue their lives. Failing this pursuit means the end of it all. Yet, it is not only the lack or scarcity of food, but also its abuse that is a major cause for disorders. Consuming food without any criteria of lawfulness, or with no heed to virtues like contentedness or gratitude, but with greed and wastefulness, leads to many health problems – mental and physical – at both individual and societal levels. Among these problems are many notorious eating disorders such as obesity, anorexia, and bulimia nervosa. Illnesses that relate to overeating, such as obesity, are now beginning to be considered as food addictions, even as a type of substance abuse, in some medical literature [1].

One serious consequence of eating and food addictions is a clinical condition that is called “metabolic syndrome” (MetS). Characterized by multiple cardiovascular disease risk factors such as obesity and high blood pressure, this syndrome has been recognized as a crucial public health problem worldwide. Characteristics such as geography, race, age and gender are influential in the frequency of the disease, which spreads daily as a pandemic that affects approximately 20-30% of the global adult population [2]. Among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 1988–1994 to 2007–2012, increasing from 25.3% to 34.2% [3].

First described by Dr. Gerald Reaven, MD, in 1988, metabolic syndrome is also referred to as “insulin resistance syndrome,” “deadly quartet,” and “civilization syndrome” [4]. In 2001, the Adult Treatment Panel (NCEP-ATP III) defined metabolic syndrome in adults as the combination of central obesity (waist circumference >102 cm in men, >88 cm in women), hypertriglyceridemia (>150 mg/dl), low HDL (<40 mg/dl in men, <50 mg/dl in women), hypertension (blood pressure> 130-85 mm-Hg), and hyperglycemia (fasting blood sugar >110 mg/dl). In 2005, the International Diabetes Federation (IDF) published a global guideline describing different thresholds for different ethnic groups. According to this guideline, the diagnosis of metabolic syndrome should be based upon central obesity and high triglyceride, low HDL, high blood pressure, and high fasting glucose. The IDF also reported that the presence of at least two factors sufficed for diagnosing anyone as a patient of metabolic syndrome.

as one of the likely pathological findings in metabolic syndrome, central obesity is observed in one in three adults. Hypertension, another crucial factor, is generally acknowledged to be originating from insulin resistance in metabolic syndrome, but the actual features of its development mechanism still remains controversial. Global awareness about hypertension, its treatment, and how to control it is low, and there are significant differences in between people worldwide. A National Health Examination Survey (NHANES) spanning 2011-2014 revealed that 34% of US adults aged 20 years and older are hypertensive and NHANES 2013-2014 data showed that 15.9% of these hypertensive adults are unaware they are hypertensive [5].

Dyslipidemia, which increases as a result of central obesity and insulin resistance in patients with metabolic syndrome, is characterized by low HDL cholesterol and high triglycerides, the most crucial factors that increase the risk of cardiovascular disease. In one study done in 2008, the average total cholesterol levels for American men and women were found to be 197 mg/dl [6].

The presence of overt diabetes or impaired glucose tolerance (fasting blood sugar above 110 mg/dl) indicates the first step of the diagnostic criteria of the metabolic syndrome, and insulin resistance is not sought for further. People diagnosed with metabolic syndrome are 2.34 times more likely to contract diabetes [7]. A 2011 study conducted in America reported that roughly half of all adults have impaired glucose metabolism as a result of type 1 diabetes, type 2 diabetes, and prediabetes. Diabetes has been a prevalent global ailment similar to asthma, autoimmune diseases, and cancer [6].

Insulin resistance, which can be observed in metabolic syndrome, increases the risk of cardiovascular disease by 2.35 times, deaths by cardiovascular disease by 2.40 times, risk of myocardial infarction by 1.99 times, and stroke by 2.27 times, as independent of other risk factors. However, the presence of metabolic syndrome, not obesity, increases the risk of cardiovascular disease [7]. Another significant result is that women with metabolic syndrome have a higher risk of cardiovascular disease than men. Women are more likely to have central obesity than men, have a different cholesterol profile, and higher triglyceride levels that cause more coronary artery disease, while polycystic ovary syndrome, hormone support therapies, and pregnancy diabetes pose additional risk for women [8]. Fatty liver disease, cirrhosis, chronic kidney disease, polycystic ovary syndrome, gout, dementia, and decreased cognitive functions are more common in individuals with metabolic syndrome than the normal population [7].

Treatment of Metabolic Syndrome

Since metabolic syndrome is caused by environmental and genetic factors, and is appearing in people with increasing frequency, the best treatment approaches involve a well-regulated lifestyle, with the main objective being to prevent diabetes and cardiovascular diseases that cause fatal or disabling conditions. Weight loss that results from an appropriate nutrition and exercise program has a corrective effect on almost all disorders observed in metabolic syndrome.

In the treatment of metabolic syndrome, prevention of central obesity seems to be a priority solution. This can be achieved by a lifestyle planning that provides and maintains a 7-10% reduction in total body weight by limiting caloric intake and increasing physical activity. Even methods that increase weekly physical activity by 150-300 minutes and provide only a 5-7% reduction in body weight are considered sufficient to correct the metabolic syndrome. This has especially been reported to have a positive effect on lipid disorders, glucose intolerance, and hypertension, with a 58% reduction in the risk of diabetes with additional lifestyle changes [9].

Since a well-regulated diet is one of the focal points of life style change for people with metabolic syndrome, dietary models that are limited to saturated fats and cholesterol, rich in complex carbohydrates, based upon an abundant consumption of fruits and vegetables, and a restricted use of salt (for those with hypertension) are strongly recommended.

Even though the traditional Mediterranean diet is lauded as one of the vibrant treatment options in the prevention of coronary heart disease and metabolic syndrome, it is not sufficient to correct the metabolic syndrome unless the diet is in tandem with significant weight loss [10]. According to numerous studies, increasing the consumption of nutrients such as fish, vegetables, fruits, dried legumes, and unrefined grains that are rich in olive oil, omega-3 fatty acids, and antioxidants reduce the risk of coronary diseases and death. It goes without saying, that smoking and alcohol use may increase cardiovascular, metabolic and hepatic complications in patients with metabolic syndrome.

Patients with metabolic syndrome should have their blood lipids checked annually, and should be determined to keep low-density lipoprotein (LDL) cholesterol lower than 100 mg/dL, high density lipoprotein (HDL) cholesterol higher than 40 mg/dL, and triglyceride levels lower than 150 mg/dL. Diabetic patients should set their blood pressure target as lower than 130/80 mm-Hg. Changes in lifestyle such as regular exercise and a controlled diet are extremely vital. The use of low-dose aspirin to prevent complications in patients with coronary artery disease is also among treatment recommendations.

The basic sustenance that is provided to us in the form of fruits, animals, grains, and other bounties is such a precious, rich and full-fledged treasure, for which we should be grateful for. However, gluttony and wastefulness pave the way for thanklessness, disease, and even conflicts with the wisdom in the universe.

Almost all living beings are engaged in the pursuit of sustenance and revolve around this goal. We humans have been equipped with the ability to taste and appreciate all kinds of food, and can draw an appreciation for the Divine through these gifts. Just as everything revolves around sustenance, thankfulness has been placed in the center of sustenance. That is, gratitude should be at the center of all sustenance. Through gratitude, we live healthier physical, spiritual, and mental lives.

Notes

1. Meule A, Rezori V, Blechert J. Food addiction and bulimia nervosa. Eur Eat Disord Rev. 2014;22:331–337.
2. Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 2008; 28: 629-36.
3. Moore JX, Chaudhary N, Akinyemiju T. Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988–2012. Prev Chronic Dis 2017;14:160287
4. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15:539-53.
5. Alexander, Matthew R.; Eric H. Yang. “What is the prevalence of hypertension (high blood pressure) awareness of in the US?” https://emedicine.medscape.com/article/241381-overview#a2
6. Centers for Disease Control and Prevention. National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 2011. Atlanta, GA, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2011.
7. Balcı M.K, Metabolik Sendrom, Türkiye Klinikleri J Med Sci 2008;28:102-106.
8. Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 2010; 56: 1113-32
9. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403
10. Carbonneau É1, Royer MM2, Richard C3, Couture P4, Desroches S5, Lemieux S6, Lamarche B7. Effects of the Mediterranean Diet before and after Weight Loss on Eating Behavioral Traits in Men with Metabolic Syndrome. Nutrients. 2017 Mar 19;9(3).

Observing Majorana fermions in the ferromagnetic atomic chains on a superconductor. Nadj-Perge et al. Science, October 2014.

In the universe, matter and antimatter particles are always produced as a pair and, if they come in contact, they destroy each other in a flash of energy. In 1937, an Italian theoretical physicist named Ettore Majorana had proposed that there can be unique exceptions to this rule: a stable particle could exist in nature that is both matter and antimatter. Scientists have been looking for that indefinable particle, also known as the “Majorana fermion,” for seventy years. A group of researchers recently reported that they were able to detect the Majorana particle which behaves simultaneously like matter and antimatter. Researchers designed an experimental system allowing them to observe an emergent particle inside a material. They first generated an extended chain of pre magnetic iron atoms on a superconductor made of lead. Then, they cooled the material to -272 C, just about one point above absolute zero, and monitored it using a giant two-story-tall scanning-tunneling microscope, which can track electrical signal changes with very high precision. Finally, they were able to capture a glowing image of an electrically neutral particle at the ends of atomically thin iron wires. The Majorana particle was surprisingly stable and the opposing properties make the particle neutral so that it interacts very weakly with its environment. The discovery of the Majorana particle has exciting implications for several areas of modern physics, engineering, and astrophysics. For example, Majorana particles are very similar to neutrinos, as they both have very weak interactions with the matter. Neutrinos are thought to make up most of the dark matter that fill the Cosmos. Perhaps, neutrinos are simply Majorana-like particles and Majorana particles are also a candidate for what dark matter is. As an industrial application, Majorana particles can be utilized in quantum computing which aims to create computers to handle incalculable systems. The current quantum computing technology uses electrons, but they are known to be very unstable due to high interaction rates with surrounding materials. However, since Majorana particles are neutral and highly stable, they can be engineered into a variety of materials to produce more reliable and powerful quantum computing applications.

The Bitter Side of Artificial Sweeteners

Artificial sweeteners induce glucose intolerance by altering the gut’s microbiota. Suez J. et al. Nature, September 2014.

There have been conflicting and confusing findings about the health effects of artificial sweeteners over the past several decades. Some studies found that they cause weight loss and others found the exact opposite. Some studies linked them to diabetes and other studies argued otherwise. A recent study provided a series of experimental evidences that artificial sweeteners disrupt the body’s ability to regulate blood sugar, and thus may cause metabolic diseases and diabetes. Researchers, using animal models and human studies, found that sweeteners significantly alter the gut’s microbiome – the collective name of bacterial colonies living in our intestines. The composition of our gut microflora plays a critical role protecting us from pathogenic bacteria, the metabolism of indigestible components of our diet, and modulating development and regulation of the immune system. Sweeteners – in the form of saccharin, sucralose, or aspartame – are found to alter the mix of microbes in our intestines and consequently change how our bodies metabolize glucose. Constant use of sweeteners in mice and human test groups caused typical glucose intolerance symptoms in which glucose levels rose higher after eating and declined more slowly than expected. Glucose intolerance can ultimately lead to serious illnesses like metabolic syndrome and Type 2 diabetes. Although this study will cause a lot of discussions and headaches in the food industry, the link identified between microbiome and glucose intolerance will definitely inspire novel therapeutic approaches to metabolic disorders such as diabetes.

Brainy Fingertips

Edge-orientation processing in first-order tactile neurons. Pruszynski JA and Johansson RS. Nature Neuroscience, August 2014

A new study found that neurons in human skin are able to perform advanced calculations that scientists thought only the brain was capable of performing. A group of sensory neurons that extend into the skin and record touch are called first-order neurons in the tactile system. Each nerve ending branches in the skin to form about 5mm2 elliptical receptive field, with up to 8 highly sensitive zones that are unevenly distributed within the field. It turns out that these neurons not only transmit information about when and how intensely an object is touched to the brain, but they also send complex information about the touched object’s shape. Researchers found that the sensitivity of individual neurons to the shape of an object depends on the layout of the neuron’s highly-sensitive zones in the skin. Computations that require untangling geometric shape information are classified as feature extraction computations in neuroscience and are typically attributed to the immensely complex circuits of the cerebral cortex. This study showed that neuronal populations localized outside of the brain, such as first-order tactile neurons, can have advanced processing capacity similar to brain neurons. These results can also potentially improve treatments for nerve injury and rehabilitation, as scientists previously assumed that the cerebral cortex was doing all the work.

Original Article: Wang, M. et al., PNAS (published online before print on March 1, 2010).

Periodic injections of insulin to manage blood sugar levels is critical for the treatment of diabetes patients. It requires continuous monitoring of glucose levels in the blood and multiple injections of insulin in order to mimic the natural balance of sugar-insulin levels in the human body. Yet, it is often difficult to maintain this extremely sensitive hormone balance without major side effects. These complications include blindness, leg ulcers and amputations, heart vessels problems, renal insufficiency, stroke, and nerve damage in the legs and arms. Moreover, the long-term use of insulin causes the increase of body fat and bad cholesterol. A new research study on non-obese diabetic mice shows that adding leptin- a hormone responsible for appetite control- to the insulin therapy results in better control of blood sugar levels and decreases the bad cholesterol and body fat of Type 1 diabetic mice. This is promising, as it could reduce heart and circulatory complications of Type 1 diabetes. However, the leptin therapy may not have an effect on type 2 diabetes, adult type, because in this type patients already have high levels of leptin. However, it has to be shown that leptin therapy is safe and effective on humans as well. There is a long way to go before we can use leptin in practical areas.

2- Re-teaching speech with music

Original Source: Schlaug G, Annual Meeting of the American Association for the Advancement of Science (AAAS), San Diego (2010).

Nearly 800,000 people in the U.S. are faced with strokes each year, and a quarter of those are affected by aphasia, a deficit in language. Using a new melodic intonation therapy, therapists treat patients by teaching them how to sing words and phrases consistent with the underlying melody of speech. As a result, the patients continue to speak in a more “sing-songy” way than a person with normal speech patterns, according to Dr. Schlaug, professor of neurology at Harvard Medical School. After 15 weeks, 1.5 hour-long daily sessions with a therapist, the patients gradually learn to piece the sung words together into organized speech. There are two separate brain networks associated with vocal output, with the one in the left hemisphere being engaged with speech and the other one in the right hemisphere strongly responding to music and melody. For the stroke patients that had damage to the left hemisphere, this therapy may help to train similar areas on the right hemisphere, helping them to initiate a speech region in the right hemisphere. Singing facilitates necessary engagement to the right hemisphere. Images of patients’ brains before and after the therapy reveal striking structural and functional changes in the right hemisphere. This study also reminds us of the brilliance of musical therapies employed in early hospitals in the Islamic world.

3- Renewable Jet-Fuels

Original Article: Bond, J.Q. et al., Science 327, 1110 (2010).

The global need for sustainable energy resources is ever increasing and the use of renewable fuels offer promising solutions. Among others, biofuels are especially important due to the presence of direct conversion routes from plant-based waste materials to conventional liquid fuels. However, high synthesis costs and complex processing steps are major hurdles to overcome before putting biofuels forward as economically viable alternatives to fossil fuels. Researchers are therefore trying to come up with more efficient methods -and one group, from the University of Wisconsin appears to have done so. Unlike commonly utilized routes involving microorganisms, they use a novel and environmentally-friendly chemical process which is easier to control and maintain. By using an inexpensive catalyst, they convert the majority of the wasted biomass to gaseous butene and carbon dioxide, with a water-based solution of gamma valerolactone as the intermediate chemical. The butene gas is then easily transformed to high-energy transportation fuels such as gasoline and jet fuel. As an added advantage, the stream of carbon dioxide can be efficiently captured, preventing the atmospheric release of this major greenhouse gas. Under optimized conditions, the system can operate uninterrupted for 90 hours with an overall efficiency of over 75%. Successful work like this will help make biofuels cheaper for mass production, pending the meticulous analysis of its economics.

4- Salt controversy: How much is too much?

Original Article: Bibbins-Domingo, K. et al., NEJM 362, 590 (2010).

Modern humans suffer from high rates of obesity (for instance, 64% of Americans are classified as either overweight or obese) and cardiovascular diseases, with the latter being the no.1 cause of all deaths. A recent study conducted by researchers at the University of California at San Francisco suggests that reducing dietary salt by half a teaspoon a day (~ 3g) would lower the annual number of new coronary heart disease, stroke and myocardial infarction cases. Strikingly, such a modest decrease is expected to decrease deaths from any cause by 44,000 to 92,000. According to the National Salt Reduction Initiative, Americans eat at least twice as much salt as they need where 80 percent of the salt in the American diet comes from processed or restaurant-prepared foods. However, eating too much salt is not a problem for people with healthy kidneys since kidneys are designed to flush out unneeded salt. However, when people have a high salt diet, then their kidneys are over-worked. Taking into account that modest salt reduction in one’s diet won’t likely cause harm and taste buds will likely adapt to this minor change effortlessly, it seems wise to refrain from using too much salt. This would trigger bigger health benefits ranging from not overworking the kidneys to reducing the risk of deadly diseases.

5- Why don’t we get thirsty during sleep?

Original Article: Trudel, E. & Bourque, C.W., Nature Neuroscience (published online before print on February 28, 2010).

In mammals, the “internal-standard-time” is kept by a particular subset of brain cells known as “clock-neurons” which display high activity during the day and low activity during the night. A group of scientists recently reported that the clock-neurons also function as a dimmer for water regulation, allowing bodily water content to be controlled by the body. A specialized group of cells, called osmo-sensory-neurons, detect and regulate water levels in the body, through balancing the water intake via thirst and loss via urine production. When water levels are low, the sensory-neurons communicate with some hormone-releasing cells which instruct the body to store water by ceasing urine production. By using isolated brain slices from rats, the researchers showed that the clock-neurons – when active – interfere with the communication between sensory-neurons and hormone-releasing-cells to suppress the water-storage-hormone release. In contrast, when the clock-cells are inactive (i.e., ‘sleep period’) the communication is restored, resulting in an increase of hormone levels to enable water-storage. Such regulation is the reason why we are not much disturbed during sleep by neither frequent trips to the bathroom, nor excessive thirst (that would both impair the sleep quality), and reminds us the verse from the Holy Qur’an: “..and He has made the night for rest…” (Chapter Al-Anaam, 96).

6- A passage to vegetative state through fMRI

Original Article: Monti MM et al., NEJM 362, 579 (2010).

Consciousness in medicine is defined as the patient’s alertness and responsiveness to the outside world. If a patient does not respond to external stimuli, his/her medical state is considered a “vegetative state”. Researchers from Cambridge, England performed functional magnetic resonance imaging (fMRI) experiments on 54 patients who had been previously classified as either “vegetative” or “minimally conscious”. Interestingly, 5 of 54 patients exhibited distinct neuronal activities in the corresponding regions of their brains, when they are given imaginary motor and spatial tasks. For the motor task, patients are asked to imagine playing a tennis game. For the spatial task, patients are asked to imagine navigating through a familiar location. A 22 year-old man who had been in coma for five months was further evaluated by being subjected to a simple set of yes-or-no questions such as “Do you have any brothers?” and was instructed to answer these questions using one type of mental imagery, that is a motor imagery for “Yes” and a spatial imagery for “No”. He answered 5 out of 6 questions correctly. This is the first evidence that through fMRI approach one can reach the residual cognitive activity in vegetative patients and establish functional communication, raising question marks about our current handling of these so-called vegetative patients.

1. Genes and inheritance
2. Obesity
3. Lack of exercise

The diagnosis of diabetes is described as a level of sugar that is above a certain amount in the blood stream. In fact, diabetes itself is the metabolic disorder of three food sources: carbohydrates, proteins, and lipids (Cholesterol and especially triglycerides). As healthcare providers we, doctors and scientists, are very much aware that the physiology-that is, the mechanism-of this wonderful sugar metabolism is one of many harmonies existent in the human body. While patients with diabetes seek help from us, our help is limited to what we have learned-and are still learning-from the human body. Thus, the medication we use today are not miracles, but rather a good example of understanding how one of the many mechanisms in body works.

Since the discovery of insulin in 1921, a hormone that is secreted from the pancreas and the only one to work at lowering the level of sugar in the body (several others increase the sugar level)-the development of treatments for diabetes has been focused on greatly in an effort to better serve humankind. Such developments include tiny, sharp needles and pens to deliver the insulin-known as insulin pens. Currently many alternative insulin delivery methods have been developed-via the skin or lungs-yet none of these are as successful as the human body’s normal program for dealing with a rise in the sugar during stressful conditions and after meals. Despite the incredible efforts and impressive studies carried out on both animals and humans, not every method of diabetes management (treatment) is suitable for every individual. Each person is unique regarding the capacity of their pancreas to generate insulin.

In the United States, more than 20 million people have diabetes; however this number is well below the actual number of sufferers. Having enough insulin is not the solution to the problem, while resistance to the action of this hormone can limit its efficacy leaving the glucose (sugar) level high. This further suppresses the pancreas’ ability to provide insulin and the remaining glucose becomes toxic to many vital organs, causing several of the following conditions:

• Heart (heart attack)

• Liver (fatty liver)

• Brain (stroke)

• Vessels (hardening of the arteries)

• Blood (easy clotting)

• Feet (gangrene and amputation)

• Immune system (suppression of the immune system, in turn leading to a tendency to infections, giving the opportunity of germs to invade various parts of the body; in the same way increase of tuberculosis bacteria, yeast infections, pneumonia)

• Skin (late healing after abrasions or trauma)

Excess sugar is converted into cholesterol which will further accelerate the detrimental effects to the vital organs (brain, heart, kidney).

Current suggestions for the management of the problem with sugar are education, better diets, correct and regular exercise, correct medication and careful follow-up. We know that God created cures for every illness. Respecting and thinking of this will encourage many of us to concentrate on solving the problem of diabetes. Prophet Muhammad, peace be upon him, indicates “Eat and drink, but never waste” and “Leave the food table before you are full.” The diet that is recommended for people with diabetes is to eat small amounts of food during the 3 main meals and to add 3 snacks to control the undesirable rise in sugar that occurs after eating a large amount. We are informed that we are full due to the induction of tension receptors in the stomach after the meal, the induction of the brain, and the digestion of food that leads to an increase in the level of sugar in the blood stream… etc. Unfortunately, most diabetics wait for the third mechanism to operate before leaving the table; as a result, they may continue to eat and further increase their blood sugar level, and this may in turn be the reason for early or late complications in diabetes.

Today, the greatest number of diabetics per population are the Pima Indians living in Arizona. Interestingly, a new molecule that has recently been developed seems to have a preventive efficacy for the development of diabetes and to assist in its satisfactory management, even after the diagnosis of diabetes. This molecule was actually found to be present in the saliva of Gila Monster again that is fairly close to the area where these affected tribes live.

Kelly J. Smith is a clinical diabetes research scientist in Arizona. 

I hang between your stomach and your duodenum under it, attached to the intestinal mesenteries. I have two different identities in terms of my structure and function. I carry out two very different duties as a compound gland made up of both exocrine and endocrine tissues. So, I am granted a very special structure and chemical abilities to function well. One of my duties is related to the physiology of digestion: I break up the food passing from the stomach to the duodenum by pouring on it the four types of digestive enzymes I have been enabled to produce. These juices are carried through a tiny pipe to your duodenum. Two of them are used for breaking up proteins, one for carbohydrates, and one for fats. You don’t even realize it! As the food you take in passes from the stomach to the duodenum, my enzymes begin flowing faster. This is a very fine balance: while food is being digested, neither the enzymes should be wasted, nor should your intestinal walls be harmed. I don’t control the release of the enzymes. That duty is given to two hormones produced in your intestinal mucosa by the stimulus of the vagus nerve. When those hormones reach me by the bloodstream, my cells are stimulated and they secrete water, bicarbonate, and the digestive enzymes I mentioned and they flow into your duodenum through my duct.

My second job is the production of insulin and glucagon hormones, as the endocrinal pancreas. My cell clusters, which are also known as islets of Langerhans, have different types as separate groups, which you call alpha and beta. The insulin, which is produced by my beta cells, is used for regulating the glucose level in your blood. The duty of insulin is to stimulate your body cells to take the glucose in your blood and use it.

After you have a meal, the carbohydrates in it are broken down into glucose molecules, pass into the blood, and increase your blood sugar. For your body to function in a healthy way, the amount of glucose should be around 100mg/ml (it varies from 80–120). When the level is above the normal value, I secrete insulin. In this way, the sugar is carried to your cells and burned to produce energy, and its increase in your blood is brought back under control. Also, insulin helps you to store sugar in fat tissues and to turn them into fatty acids, and it slows the breaking down of fatty acids. Moreover, insulin helps you to make protein in your body by holding amino acids within your muscle tissues and storing glucose in your liver and turning it into glycogen.

The failure of my beta cells to secrete insulin is a serious problem; the consequence is “diabetus mellitus,” or what we commonly know as diabetes. A person with this disorder must abstain from various delicious foods and drinks. In cases where a strict diet does not solve the problem, patients may have to take insulin shots every day. Diabetes can cause many complications by damaging your nerves and blood vessels; I won’t go into types of diabetes so I don’t get sidetracked too much. I just wished to make a point: even a substance produced by a tiny cluster of cells can upset the functioning of many of your mechanisms. After having a meal, put your hand to the left of your abdomen below the stomach and remember what a blessing I am!

As for the glucagon hormone I secrete from my alpha cells, it does just the opposite of insulin and causes the sugar stored in your cells to be released into your bloodstream. When your blood sugar decreases-due to hunger, overwork, exercise, and so on-it causes the glycogen in your liver to be used in order to increase the level of your blood sugar. As adrenalin secreted by the adrenal glands helps glycogen to be broken down and to be released into the blood as glucose, they function as an integrated system. Glucagon also slows down the synthesis of glycogen, and it accelerates the break-up of proteins and fat metabolism. I think now you get it, Peter. Insulin and glycagon are parts of a biological feedback mechanism controlling one another. People discovered all these facts after years of lab research; now do you see how ridiculous it is to see me as a work of blind chance?

Like any other organ, I can also contract various diseases. The most common ones are acute or chronic inflammation, tumors, and cysts. I am easily troubled with inflammation in people with alcohol habits. Since enzyme secretions-and therefore digestive processes-are then not carried out properly, some undigested fats and fibers with proteins are excreted with the feces. A problem can arise with the intestines due to digestive deficiency. And if I completely fail to fulfill my duty owing to a chronic inflammation or tumor, then doctors take me out and you become dependent on insulin and a special liquid obtained from the pancreas.

It is sad to say that my cancer is not quickly recognized. It develops very fast and I try to keep up my duty as long as possible. Therefore, it is usually too late when diagnosed. There is nothing much modern medicine can do after it spreads. Although it is not definite yet, I suspect cigarettes play a role in my cancer.

As for diabetes, even though a promising method of treatment has been discovered, certain problems haven’t been overcome yet. The transplant of beta cells from the pancreas of someone who has just died-with as much tissue compatibility as possible-has had partial success. As with every other organ transplant, tissue rejection is a challenge. If the human genome project succeeds and the genetic code of the human body is thoroughly solved, it may be possible to cure diabetes by genetic engineering techniques. This is only at research level for now, but if scientists do their best, it is possible to find a way, since there is a treatment for every disease except for old age and death. You see Peter, as the vicegerents on earth, you humans are supposed to explore the secrets of the universe and appreciate the beauties you discover. I think I have said enough now. Thanks for listening, Peter!

Irfan Yilmaz is a professor of biology at Dokuz Eylul University, Izmir, Turkey.

I am sure, to most of us who have learned about scientists as unapproachable figures sitting on top of Mount Everest (and somehow almost all of whom are Western), this viewpoint may seem quite new. Yet, there is more to it. The same thinker points to another equally important factor in the development of civilization and advancement of sciences: with a great strength in his weakness and potency in his impotence, man is very much like a pampered child in creation. If he recognizes his weakness and performs his worship with his words, actions and state of mind, if he knows his own impotence and asks for God’s aid, he will then have fulfilled the obligation of gratitude for the subjugation of creation to his needs.

As with a petted child who by means of a little cry or simply a sad look obtains the assistance of adults to serve him: even the tiniest part of what they do for him by far exceeds what lies in the child’s own power to do for himself, and their great help he owes to his great weakness. So too, the apparent dominance of man over the rest of creation and his progress in civilization are not the result of his own deserving but they were subjugated to him because he himself was weak: he received aid because he was helpless; he was enriched thereby because he was poor; he was inspired because he was ignorant; he was bestowed with favours because he was in need of them (Nursi, 23rd Word). 

Penicillin

Most people believe that great discoveries are results of deliberate, directed effort, planning. exhaustive experiment and logical inference. The discovery of penicillin is the most famous counter example. Although the role of planning, experimenting and research has an undeniable role in scientific discoveries, events do not always form a logical sequence, and this is what I am here trying to emphasize.

During World War I, doctors depended on antiseptics to cure battIe wounds. A. Fleming, a bacteriologist, observed that phenol (or carbolic acid, the most common antiseptic at that time) did more harm than good, in that it killed the leukocytes (white blood cells) faster than it killed the bacteria, and he knew this was bad because the leukocytes are the body’s natural defenders against bacteria.

In 1922, while suffering from a cold, Fleming made a culture from some of his own nasal secretions. As he examined the culture dish filled with yellow bacteria, a tear fell into it from his eye. The next day, when he examined the culture, he found a clear space where the tear had fallen. He correctly concluded that the tear contained a substance that caused rapid destruction of the bacteria, but was harmless to human tissue. The antibiotic enzyme in the tear he named lysozyme. It turned out to be of little practical importance because the germs that lysozyme killed were relatively harmless, but this discovery was an essential prelude to that of penicillin.

In the summer of 1928, Fleming was engaged in research on influenza. While doing some routine laboratory work involving microscopic examination of cultures of bacteria grown in petri dishes (flat glass dishes provided with covers), Fleming noticed in one dish an unusual clear area. Examination showed that the clear area surrounded a spot where a bit of mould had fallen into the dish, apparently while the dish was uncovered. Remembering his experience with lysozyme, Fleming concluded that the mould was producing something that was deadly to the staphylococcus in the culture dish. Later he would say: ‘There are thousands of different moulds and there are thousands of different bacteria, and that chance putting the mould in the right spot at the right time was like winning the Irish sweep.’

Fleming’s own words are enough as a response to those who attribute scientific discoveries to chance or idolize scientists. However, I will give other examples to make the point clearer.

Teflon

From non-stick frying pans to space suits to artificial heart valves, Teflon has found several areas of application. Its discovery resulted from an apparently ‘accidental’ observation by a young chemist, R. Plunket, working in Du Pont laboratories. On April 6, 1938, Plunket opened a tank of gaseous tetrafluoerothylene in the hope of preparing a non-toxic refrigerant from it, but no gas came out, to the surprise of Plunkett and his assistant. Plunkett could not understand this because the weight of the tank indicated that it should be full of the gaseous fluorocarbon.

Instead of discarding the tank and getting another in order to get on with his refrigerant research, Plunkett decided to satisfy his curiosity about the ‘empty tank’. Having determined that the valve was not faulty by running a wire through its opening, he sawed the tank open and looked inside. There he found a waxy white powder and, being a chemist, he realized what it must mean.

The molecules of the gaseous tetrafluoroethylene had combined with one another ‘polymerized’ to such an extent that they now formed a solid material. The waxy white powder did indeed have remarkable properties: it was more inert than sand – not affected by strong acids, bases or heat and no solvent could dissolve it – but, in contrast to sand, it was extremely slippery.

X (Roentgen) Rays

Physicist W. Roentgen discovered the rays which were later to be named after him, in an unexpected and unplanned manner. Roentgen was repeating experiments by other physicists in which electricity at high voltage was discharged through air or other gases in a partially evacuated glass tube. We now know that cathode rays are actually streams of electrons being emitted from the cathode, and the impact of these electrons on the walls of the glass tubes produces the phosphorescence.

In 1892, it was demonstrated that cathode rays could penetrate thin metallic foils. Discharge tubes having thin aluminium windows allowed the cathode rays to pass out of the tube where they could be detected by the light they produced on a screen of phosphorescent material (such screens were also used to detect ultraviolet light), but they were found to travel only two or three centimetres in the air at ordinary pressure outside the evacuated tube.

Roentgen repeated some of these experiments to familiarize himself with the techniques. He then decided to see whether he could detect cathode rays issuing from an evacuated all-glass tube, that is, one with no thin aliminium window. Na one had observed cathode rays under these conditions. Roentgen thought the reason for the failure might be that strong phosphorescence of the cathode tube obscured the weak fluorescence of the detecting screen. To test this theory, he devised a black cardboard cover for the cathode tube. To determine the effectiveness of the shield, he then darkened the room and turned on the high voltage coil to energize the tube. Satisfied that his black shield did indeed cover the tube and allowed no phosphorescent light to escape, he was about to shut off the coil and turn on the room lights so that he could position the phosphorescent screen at varying short distances from the vacuum tube:

Just at that moment, he noticed a weak light shimmering from a point in the dark room more than a yard from the vacuum tube. At first, he thought there must be, after all, a light leak from the black mask around the tube, which was being reflected from a mirror in the room. However, there was no mirror. When he passed another series of charges through the cathode tube, he saw the light appear in the same location again, looking like faint green clouds moving in synchronism with the fluctuating discharges of the cathode tube. Hurriedly lighting a match, Roentgen found to his amazement that the source of the mysterious light was the little fluorescent screen that he had planned to use as a detector near the blinded cathode tube, but it was lying on the bench more than a yard from the tube.

Roentgen realized immediately that he had encountered an entirely new phenomenon. These were not cathode rays that lit up the fluorescent screen more than a yard from the tube! With feverish activity, he devoted himself single-mindedly in the next several weeks to exploring this new form of radiation. He reported his findings in a paper published in Wunburg, dated December 28, 1895, and entitled ‘A New Kind of Ray, a Preliminary Communication’. Although he described accurately most of the basic qualitative properties of the new rays in this paper, his acknowledgement that he did not yet fully understand them was indicated by the name he chose for them, X-rays. (They have also often been called Roentgen rays.)

He reported that the new rays were not affected by a magnet, as cathode rays were known to be. Not only would they penetrate more than a yard of air, in contrast to the two or three inch limit of cathode rays, but also (to quote his paper):

‘All bodies are transparent to this agent, though in very different degrees. Paper is very transparent; behind a bound book of about one thousand pages I saw the fluorescent screen light up brightly. In the same way the fluorescence appeared behind a double pack of cards. Thick blocks of wood are also transparent, pine boards two or three centimetres thick absorbing only slightly. A plate of aluminium about fifteen millimetres thick, though it enfeebled the action seriously, did not cause the fluorescence to disappear entirely. If the hand be held between the discharge tube and the screen, the darker shadow of the bones is seen within the slightly dark shadow image of the hand itself.’

He found that he could even record such skeletal images on photographic film. This property of X-rays captured the attention of the medical world immediately. In an incredibly short time X-rays were used routinely for diagnosis in hospitals throughout the world.

Insulin

If a relative or a friend of yours has diabetes, you will probably know how important insulin is for them. As a partial remedy for most diabetics today, insulin was discovered as an answer to the prayers of hundreds of thousands of diabetics by the Most Merciful One. Perhaps, even better relief and remedy are awaiting discovery in some unexpected time or place.

In 1889, while studying the function of the pancreas in digestion, two researchers removed the pancreas from a dog. The very next day a laboratory assistant called their attention to a swarm of flies around the urine from this dog. Curious about why the flies were attracted to the urine, they analysed it and found it was loaded with sugar. Sugar in urine is a common sign of diabetes.

The researchers realized that they were seeing for the first time evidence of the experimental production of diabetes in an animal. The fact that this animal had no pancreas suggested a relationship between that organ and diabetes. The researchers subsequently proved that the pancreas produces a secretion that controls the use of sugar, and that lack of this secretion causes defects in sugar metabolism then exhibited as symptoms of diabetes.

Many attempts were made to isolate the secretion, with little success until 1921. A young Canadian medical student extracted the secretion from the pancreas of dogs. When they injected the extracts into dogs rendered diabetic by removal of their pancreases, the blood sugar levels of these dogs returned to normal or below, and the urine became sugar-free. The general condition of the dogs also improved.

Until recently, all insulin used for the treatment of human diabetes came from the pancreases of some animals. As a result of genetic engineering, based on knowing how DNA controls protein synthesis, a major pharmaceutical firm has begun to produce human insulin by using bacteria. The fact that a microscopic creature, like the bacterium can be made to work for the wellbeing of human beings is a subject worthy of study on its own.

Of course, these are by no means the only examples worth mentioning of ‘happy, chance discoveries’. Here are some more to add to the list: the discovery of molecular structure of organic compounds, saccharin and nutra-sweet (sugar substitutes, again for diabetics), ‘safety glass used in automobiles and planes, oxygen and several other chemical elements, radioactivity, astronomical discoveries like pulsars and background Big Bang radiation, many mathematical theorems, high temperature superconductors, synthetic dyes, etc., etc.

Can one really call all of these marvellous discoveries simply ‘happy, chance accidents’? I believe human conscience and reason must resist such a misconception. Surely, any person of common sense would say: ‘I am thankful to the Merciful One, who has bestowed upon us the favour of these discoveries, enabled us to benefit from them, among His innumerable other bounties’.