In 1981, scientists discovered ways to derive embryonic stem cells from early mouse embryos. Since then, they have been the subject of intense scrutiny, controversy, and advocacy.

They are unique cells, which can be derived from human embryos and can be differentiated into virtually any kind of different cells. In humans, there are about 200 different types of cells including bone, muscle, and nerve cells, and within these cells there are about 20 different types of structures or organelles. Essentially, stem cells can be derived from human embryos, and with the right enzymes, can be stimulated. For instance, bone cells can originate from osteocyte cells, or liver tissues can come from hepatocytes.

Stem cell types and research

There are three types of stem cells:

• Embryonic stem cells
• Adult stem cells
• Induced Pluripotent Stem Cells (iPSC)

Embryonic stem cells are derived from human embryos. Adult stem cells are undifferentiated cells (meaning “clean slates” with the potential to change into another cell variant) found throughout the body after development; they multiply via cell division to replenish dying cells and regenerate damaged tissues. Induced Pluripotent Stem Cells (iPSC), which were discovered in 2006, are derived from skin or blood cells that have been reprogrammed back into an embryonic-like pluripotent state that enables the development of an unlimited source of any type of human cell needed for therapeutic purposes. While these types of cells are interesting and certainly worthy of research, this article will focus on embryonic stem cells as they are consistently the most well-known and discussed type by the general public.

Embryonic stem cells are potent and often sought after due to their abilities to proliferate without limit and contribute to any cell type. However, with great power comes great responsibility and stem cells are no exception. Poorly processed cells have been documented to mutate into cancerous tumors that can wreak havoc upon people’s bodies. Bearing this in mind, scientists also do not believe that this should derail stem cell therapies considering that there are DNA tests to check if stem cells will turn out to be problematic or not.

The stem cell project is regularly a subject of ethical debate in both the academic and public sectors. Most embryonic stem cells are derived from embryos that develop from eggs that have been fertilized in vitro—in an in vitro fertilization clinic—and then donated for research purposes with the informed consent of the donors. People willingly donate their eggs for this research, and this process does not constitute child-killing since the eggs are near their zygote phase, not a whole mature embryo. Scientists obtain those types of cells from an embryo which has not yet completed its formation to develop into a human being. Researchers then use these cells for various treatment and research purposes. It is important to stress that they are not derived from eggs fertilized in a woman’s body and that they are produced in a plastic laboratory culture via clinics in vitro.

Some examples of embryonic stem cells being used in research include the following:

1. UCLA stem cell gene therapy cures bubble baby disease

Researchers at UCLA (University of California, Los Angeles) have developed a cure for babies born with Bubble Baby Disease, a rare and life-threatening condition that can be fatal within the first year of life, by using stem cells from multiple patients and gene therapy to correct the genetic mutation of these patients.

2. Asterias biotherapeutics restores some independence to those suffering from paralysis caused by spinal cord injuries

Asterias Biotherapeutics spent much of 2016-2017 developing a stem cell therapy to restore upper body motor function to quadriplegic spinal cord injury victims. Through lengthy and rigorous testing in human clinical trials, the therapy was found to be safe for use in people with all patients treated reporting at least some improvements. Asterias is now expanding its clinical trials to include patients with sub-acute injuries.

3. UC Irvine scientists engineer stem cells to destroy cancer

In a study conducted by University of California, Irvine researchers, a stem cell-based technique was devised to find and destroy breast cancer cells that had already metastasized. The cells “feel” the stiffness of the surrounding tissues and destroy the cancer-causing cells.

Embryonic stem cells can remain undifferentiated when they are grown in a well taken care of culture that is under stable conditions. Problems primarily begin to arise if cells are allowed to clump together to form embryoid bodies in which they begin to differentiate, or change into more specific cell variants, spontaneously. Although spontaneous differentiation is a good indication that shows which cultures of embryonic stem cells are healthy, the process is uncontrolled and, therefore, an inefficient strategy to produce cultures of specific cell types.

The ability of stem cells being able to differentiate into hundreds of other types of cells continues to amaze scientists as this is no small discovery. Researchers believe that the possibilities with stem cells are near endless, especially in regard to “regenerative medicine,” the process of “replacing, engineering, or regenerating human cells, tissues, or organs to restore or establish a new function.” It is even believed that even whole organs could be synthetically grown by using them.” Additionally, stem cells have the potential to rebuild healthy tissues, help people with heart disease, diabetes, ALS, Alzheimer’s disease, liver disease, Parkinson’s disease, cancer, and many more illnesses.

In a stem cell transplant, embryonic stem cells are first specialized into the necessary adult cell type. Then, those mature cells replace tissue that is damaged by a disease or injury. This type of treatment could be used to:

• Replace neurons damaged by spinal cord injury, a stroke, Alzheimer’s disease, Parkinson’s disease, or other neurological problems.
• Produce insulin that could treat people with diabetes and heart muscle cells that could repair damage after a heart attack
• Replace virtually any tissue or organ that is injured or diseased.

Sometimes scientists use stem cells as a drug. For example, it is possible to inject a stem cell into joints to reduce swelling and pain, or in order to promote the healing processes of soft tissues. Stem cell therapy is performed by injecting the patient’s own stem cells to stimulate the body to repair and replace damaged tissue in any joint or soft tissue structures – such as knees, shoulders, hips, wrists, ankles, elbows, tendons, ligaments and non-healing bone fractures. Cellular Dynamics, a large biotechnical company, sells human heart cells called cardiomyocytes that are derived from induced pluripotent stem (IPS) cells. Pharmaceutical companies are adapting to this new and innovative trend on a day-to-day basis. Stem cells can also be used to test the quality and safety of investigational drugs by testing them on stem cells that have been transformed into tissue-specific cells. Researchers are able to monitor the side effects before exposing the drug to a patient and thus have a greater expectancy of how their body may respond to the drug. This allows us to test for cures for potentially fatal diseases in ways that would otherwise be risky or unethical.

With all of the aforementioned advantages, stem cells are a fairly new, but exceptionally promising, research area. For some people, it may seem unethical to use stem cells on the grounds that extracting stem cells damages the blastocyst, which is a structure formed in the early development of mammals, more specifically the sixth or the eighth day of the development of an embryo. In 2006, President Bush vetoed the Stem Cell Research Enhancement Act stating that the federal government should not support “the taking of innocent human life.” Although stem cells are very promising for science and can open new doors to many new treatments in the medical field, it looks like there are still differences of opinion on their ethical use. This is perhaps because there is need for more convincing evidence or people are not informed accurately on the details of this research area.

References

• https://stemcells.nih.gov/info/Regenerative_Medicine/2006Chapter1.htm
• https://www.healthline.com/health/stem-cell-research
• https://www.statnews.com/2017/04/26/stem-cells-cancer-mutations/
• https://plato.stanford.edu/entries/stem-cells/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398703/
• https://www.mayoclinic.org/documents/the-amazing-stem-cell/doc-20249792
• https://www.unmc.edu/stemcells/educational-resources/history.html
• https://www.cirm.ca.gov/patients/power-stem-cells
• https://www.nature.com/news/stem-cells-take-root-in-drug-development-1.10713
• https://hsci.harvard.edu/examining-ethics-embryonic-stem-cell-research#:~:text=Opponents%20argue%20that%20the%20research,taking%20of%20innocent%20human%20life.%E2%80%9D

Embryonic stem cells are cells in the early stages of embryonic development when a fertilized egg cell is divided first into two cells and then into four, eight, and sixteen. Each grows into a brand new cell type and multiplies as per the codes present in its DNA program as tissues form and organization starts. 

After twenty years of research and accompanying debates on the human embryo, we are finally on the threshold of both reshaping our present concepts in biology and moving on to clinical case studies. The first human embryonic stem cells were produced in 1998. Studies researching the question, “Can we treat diabetes by reprogramming the DNA in these cells at the beginning of life?” switched first to how human genes worked and which genes are responsible for the development of particular tissues and then to the embryonic stem cells for these areas and ultimately to replacing or reprogramming a “faulty or deficient” gene.

The most controversial topics in genetics and embryonic studies are related to bioethics. Many scientists are grappling with questions like whether is it ethically correct to intervene with the genetic programming of a fertilized human egg (zygote)? If so, what should be the limits? Are we trespassing a divine domain?

Embryonic stem cells have been an excellent source of information that we lacked throughout history about how living organisms started to develop. Like astronomers who trace their knowledge to the Big Bang in order to obtain fundamental information about the origin of the universe, biologists have been researching how the molecules in a single cell went through sequential and planned changes, how they transformed and acquired new functions that triggered the mind-blowing developments in diverse, miraculous living organisms. Scientists have found out how primordial embryonic cells transformed into more than 200 cell types that constitute various tissues and organs. The number of studies has skyrocketed about which molecule types can be used to regenerate the damaged tissue, say, after a traffic accident. Embryonic studies that focus on the regeneration or reparation of medulla cells (spinal cord) have been a source of hope for some patients with permanent paralysis because of a broken back injury or severed spine in a traffic accident or those who are still stranded in wheelchairs. Similarly, the preliminary findings of research into Parkinson’s and diabetes are extremely promising, and a new study reports of two blind people with macular degeneration (which causes blindness) who have been treated.

Initial studies

In 1981 researchers successfully obtained stem cells from a rat embryo culture. They soon realized that the cells held a secret potential: they could grow into 200 different types of cells. Later Wisconsin-Madison University biologist James Thomson derived stem cells from primates for the first time. Three years afterwards, Thomson derived the first human embryonic stem cells from donated but unused embryos.

The increasing number of research studies into embryonic stem cells sparked off intense debate both in religious circles and among the science community that care passionately about the sanctity of humans. Allegedly, lab studies were conducted on human embryos without restrictions, which were grown until tissues and organs formed but were then killed. In 2001, the US president George W. Bush slashed federal funds, stating that stem cell research was not strictly ethical. Deriving embryonic cells was banned in many countries including Germany and Italy. In other countries, however, studies went full speed ahead. Indeed, reports flooded in about stem cells grown by researchers in Australia, Singapore, Israel, Canada and the USA into nerve cells, immune system cells, and heart cells.

Before long, a new idea emerged about transferring new cells into the egg cell – like nuclei of body cells used in cloning Dolly the sheep – to produce various tailor-made, fully DNA-compatible tissues and organs, as they had the same genome as the donor’s. It became a topic of everyday conversations that spare organs could be cultivated for the human body just like spare parts of cars or other machinery were produced to replace a faulty or damaged part. In fact, if it were not for claims such as “creating a new human” there would be no objections against producing a kidney, lung, or heart from the DNA of a patient and thus overcome the major problem of tissue rejection in transplantation of organs.

If faulty or defective genes could be removed and replaced by healthy genes in the DNA of stem cells, many incurable genetic diseases could easily be fixed and many prospective parents who avoid having a child because of a defective gene they carry would welcome the development enthusiastically.

We are on the threshold of reshaping our present concepts in biology and moving on to clinical case studies. Embryonic studies have been a source of hope for even patients with diseases like paralysis and blindness.

Just in time and in the right amount

Embryonic stem cells are cells in the early stages of embryonic development when a fertilized egg cell is divided first into two cells and then into four, eight, and sixteen. Each grows into a brand new cell type and multiplies as per the codes present in its DNA program as tissues form and organization starts. It is most mysterious and miraculous that the molecules that lead a stem cell to transform into a new type of cell are synthesized at exactly the right moment and in the precise amount.  Scientists are currently trying to figure out which molecule leads a cell to become a nerve, muscle, or bone cell when attached to it. They are likely to decode the molecules by monitoring the tissues that remain undeveloped because of missing genes resulting from DNA mutations observed in certain genetic diseases.

The new field that has developed in the last two decades called regenerative medicine is predicated on tapping into the potential of stem cells by repairing missing or faulty tissues, or completing a link in the chain necessary for the functioning of a dysfunctional metabolic process. In 2006, stem cell biologist Shinya Yamanaka of Kyoto University in Japan successfully transformed adult rat cells into an embryonic state. The following year, human body cells were transformed into embryonic stem cells. The ensuing research has led to the acknowledgement that it was theoretically possible to transform stem cells into any cell type, a promising cure for diseased embryos that have genetically missing parts.

The major problem, however, is keeping these delicate cells alive in a culture medium. In 2007, Yoshiki Sasai discovered a molecule called rock inhibitor that nourished the cell colonies he grew. The success rate in generating new cell colonies rose to 27%. Parmar from Swedish Lund University heralded “a new golden era” by producing new neurons from embryonic stem cells for the treatment of Parkinson’s.

As new techniques were developed for producing cells fast and reliably, these cells turned out to involve a very low risk of developing cancer. “We don’t yet know how this hidden power and balance that can be transformed into any cell type is controlled,” states Hiromitsu Nakauchi, a stem cell biologist at Tokyo University who researches making blood platelets out of stem cells derived from the embryo or somatic cells.

Experiments are underway that aim to treat disorders by activating stem cells stored in the body that have not yet differentiated through the help of proper stimulating molecules. 

Miraculous differentiation

As the techniques for producing and feeding stem cells got easier, researchers aimed at growing and forming tissues and organs. A connective tissue or an outer covering like the skin that lacks a shape but takes the shape of the underlying muscles and bones can be produced even in a Petri dish and then transplanted to a burned or missing area of the skin. The present aim is the production of organs such as the kidney or the heart that has a particular shape and is made up of a number of different tissues. If the correct signal molecules responsible for cell division and differentiation can be identified and readily used where necessary and at the right amount, then organs including any type of tissue can be produced. Researchers like James Wells at Cincinnati Children’s Hospital in Ohio have tested the damage of drugs on intestines by using the partial intestines they developed from stem cells rather than administer them to normal humans, thereby hailing the imminent age of intestine transplants.

In 2004, the doctors who did tube baby experiments for a patient in Chicago known to have a genetic disorder started to produce a series of stem cells from generated embryos. They made models at the cellular level of the emergence of such genetic disorders as thalassemia, Huntington’s disease, Marfan syndrome, and muscle dystrophy. In 2007, they used embryonic stem cells to suppress molecular changes that trigger mental disorders caused by a genetic disorder called fragile X syndrome.

Research shows that multipotent (mesenchymal) cells stimulated at the outset of tissues are even more promising than embryonic cells with respect to diseases because it is easier to repair damaged or missing tissue by guiding them. However, it is essential in a genetic disorder that cells derived at the beginning of the embryonic stage should be used in order to replace faulty genes with healthy ones and address the disorder at its outset.

Experiments are underway that aim to treat disorders by activating stem cells stored in the body that have not yet differentiated through the help of proper stimulating molecules. In this way, as many as ten illnesses are likely to be treated, some of which include diabetes, macular degeneration in the eye, and neurodegenerative diseases such as Parkinson’s.

Douglas Melton from Harvard Stem Cell Institute in Cambridge has worked for fifteen years to transform embryonic stem cells into insulin-producing β-cells. He has produced pancreatic cells that sense glucose and produce insulin and he hopes to transplant them to end the dependence of patients of diabetes type-1 on insulin shots. The last obstacle remains to be the introduction of these cells to the system so that they are not destroyed by the patient’s immune system.

Clinically, it is believed that stimulated multipotent cells have a greater advantage than embryonic cells because the produced cells and tissues have the same DNA as the patient and thus do not cause any immune reaction when they are transplanted. The problem for many genetic disorders including type-1 diabetes is that the patient has the same mutation in his or her genes, and a method should be devised for cleaning and replacing these cells.

Another problem is the cost. It is reported that preparation of a series of multipotent cells will cost about one million dollars. However, the cost is expected to decrease and cells will be developed for the treatment of Parkinson’s disease, which is caused by a loss of neurotransmitter substance, which enable communication between nerves, and dopamine.

Treatment of macular degeneration is a popular target in this field. Patients gained the ability to read, though slowly, one year after the transplantation of part of stimulated multipotent cells to a damaged retina.

Such research studies normally cause some opposition. Playing with genes and embryos involve certain ethical and health risks. Yet, as reported in a Prophetic tradition, with all our God-given abilities like intelligence, curiosity, and willpower, humans can, and hopefully will, find cures for all diseases. Research into stem cells has the potential to provide many breakthroughs in these efforts to find healing for every human. Scientists and ethicists have to work together to determine our direction not to cause any unintended harm to any single soul while moving forward with this research.

We have seen tremendous transformations in every field of human scientific study including artificial intelligence, genetic engineering, nanotechnology, robots, animal cloning, computers, innovative internet devices, and thousands of other gadgets. Researchers and scientists constantly discover new technologies for the benefit of mankind. One of the most revolutionary breakthroughs has been the discovery and usage of stem cells.

Stem cells are undifferentiated biological cells that can be differentiated into specialized cells and can divide, through mitosis, to produce more stem cells. These new cells can be used to treat diseased human organs. They destroy the diseased cells and grow healthy cells within the organ until the organ becomes disease-free.

The discovery of stem cell

From 1961 to 1963, Doctor James Till and Doctor Ernest McCullach did pioneering research on hematopoietic (production of blood cells in the bone marrow) stem cells. Though they are called the discoverers of stem cells, some scientists are of the opinion that researchers were working on stem cells as early as 1918. Soon after Till and McCullach “discovered” stem cells, other scientists discovered ways to derive stem cells from mouse embryos. Scientists are now able to derive the cells from human embryos and grow them in labs. In 1998, a team led by James Thomson and Jeffrey Jones, from the University of Wisconsin in Madison, developed the first batch of human embryonic cells for use in medicine.

Sources of stem cells

Embryos: Stem cells were initially obtained from umbilical cord blood just after birth, though there were strong protests in opposition to this practice by the leaders of many faiths. This movement somewhat restrained the procedure. Scientists later on learned how to extract stem cells from embryos that had been fertilized through in-vitro fertilization and donated for research. These embryonic cells can mature into any kind of human cell.

The brain and spinal cord: Some types of neural stem cells produce fatty insulation that protects nerves.

Skin: Cells obtained from skin can be genetically manipulated to behave like stem cells.

Bone marrow: These stem cells can transform into bone, fat, tendon, or cartilage cells.

Extraction of stem cells

A patient is given local anesthesia to numb the body part. A doctor then performs a liposuction to remove fat tissue from the hip, waist, or other part of the body. The fat tissue is spun in a centrifuge to separate stem cells from the tissue. These stem cells are reinjected into the patient’s body, directly into the joints, tendons, or ligaments – a procedure called Regenerative Stem Cell Therapy.

Regenerative therapy clinics

There are currently hundreds of such clinics operating in many countries including United States, Canada, and Mexico. They offer cutting-edge technology to help restore patients’ health. However, some of these clinics are not approved by the FDA and are likely to jeopardize the patient’s health. The FDA has approved stem cell treatment for blood and immune disorders, certain types of cancer, and skin grafts for burns. There are doctors and clinics that offer stem cell treatment for all sorts of ailments with costs running in the thousands for therapies that the FDA has not approved. The FDA does not take action against these clinics because their usage is considered part of a medical procedure without the use of any drug.

The cosmetic industry also makes use of stem cells.Cells that have been mixed with fat can be  injected during a face-lift to make the skin appear shiny and youthful.

Thousands of people benefit from stem therapy. However, certain cases document potential harmful effects on patients, especially those patients who go to clinics not approved by the FDA. Medical staff in such clinics are generally inexperienced in stem cell therapy.

Linda Marsa’s article in the 2017 July and August issue of AARP Bulletin reports on some patients who either lost their lives or were seriously harmed after stem cell therapies. Two of them were from Florida. They died after receiving stem cell injections. A third person in California developed bone fragments in her eyelids after a stem cell face-lift. In another incident, three older women lost their vision after they participated in a so-called clinical trial, for which they had paid in South Florida. They were injected with stem cells to treat their macular degeneration. Before the injection, they had functional vision, they could move without any assistance and they could watch TV. But there was the prospect of further deterioration, which basically meant that they could potentially lose their driver’s licenses. The content in the clinic website was too convincing that they agreed to pay $5,000 for injections in both eyes. In about thirty minutes, the tissue was harvested, and stems cells were injected into the vitreous cavity of both eyes. The injection was done by a nurse and no doctor supervised the procedure.

Unfortunately, only a few days after the injection, they felt severe pain and vision loss. Thomas Albini, an ophthalmologist at the University of Miami, thinks when the stem cells started dividing, they caused the retina to detach. “There was nothing we could do to bring their vision back,” Albini said. “All three are now legally blind and unable to live independently.”
The stem cell industry is rife with fraud, dishonest practitioners and malpractice. One should beware of such clinics and go to only those which have been approved by the authorities and where doctors are thoroughly conversant with new therapies.

State-of-the-art clinics

The good news is that there are many other clinics that work strictly as per the approval of FDA (US Food and Drug Administration) procedures. The Stem Cell Institute of America has centers in Illinois and is reputed to be a genuine place where patients are generally satisfied with the results of their procedures. The SCIA offers stem cell injections for arthritis and other degenerative conditions found in the knees, hips, shoulders, neck, and lower back. Doctors and nurses are highly trained to administer these treatments.
Other reputable clinics include the Stemedix Medical Clinic and the U.S. Stem Cell Clinic, both in Florida, along with a chain called the Cell Surgical Network which is based in California.

Dr. Mark Berman, a plastic surgeon in Beverly Hills, California, established Cell Therapy Centers in 2002. He claims that he and other physicians in his network have performed more than 5,000 stem cell treatments including on himself and his wife.

Sally Temple, a stem cell researcher at the Neural Stem Institute in Rensselaer, NY, and President of the International Society of Stem Cell Research, says:

We are going to see many treatments for diseases that are currently incurable. The results researchers are so excited about are only possible because of decades of tedious work to establish safety protocols, test concepts, and (to) learn how to grow, produce and manipulate stem cells. It is hard to have people understand how long this whole process takes. You would not believe what we have to do in my lab to prepare cells properly.

Stem cell treatment helps in many cases, but it is not yet approved for very serious conditions like strokes, heart ailments, or spinal cord injuries. Research is still ongoing and it may take decades to fully discover how stem cells can be utilized for such conditions.

Reference

• Angela Nice. “Dr. Mark Berman, and his innovative stem cell surgery,” Feb 12, 2016. New Skin Beverly Hills Posts.

Before thinking about biology’s future, we should classify the most important developments made during the 1990s. The first one is cloning, most notably the sheep Dolly, a development that is still quite controversial. The problem here is twofold: religious, for some people say that scientists want to play God by “creating”; and ethical, for it could involve cloning human beings to harvest their organs. Technically, this latter issue is not a big deal.

Cloning

To deal with the first issue, we must understand the cloning process. Cloning is defined as the transfer of an ordinary cell nucleus to an egg with a depleted nucleus. Scientists have done this with frogs for years. But when they began to use mammals, people began to pay more attention.

Cloning is not creation, for it uses an existing genome encoded in an existing nucleus with a natural (but slightly modified) egg. So, the resulting organism is no more than a copy of the organism already created by the Creator.

In other words, cloning is like a copier: if you photocopy a book, you cannot claim that the copier wrote that book, even if there are some changes (e.g., lighter ink or different colors). Even if scientists one day change a portion of the genome prior to cloning so that the clone will have a different physical property, they still will be doing no more than making some small changes on a great piece of art already designed and created in a wonderful way.

The second issue, that of cloning people, is also important. The American government has already outlawed it. Why would someone want to clone himself or herself or someone else? There could be several reasons. First, to live forever, which is impossible. Even if everything were to work perfectly, the clone would be an entirely “new” person with a unique personality, for its environment would be an important factor in its development.

Second, to use the clone as an organ donor or for some other reason. A clone’s organs would not be rejected by the recipient’s immune system. However, cloning a human being just to harvest its organs is the same as killing someone for his or her organs. Although cloning now is a technically very painful and long process, advancements in biomedical technology probably will make it much easier in a few years, and available to those who can afford it.

Clearly, this process does not involve creating a new person. However, it does raise ethical complications, such as the ones mentioned above. To allay some of the public’s concerns, scientists should explain that “cloning” does not mean “creation.”

Genetic Manipulation

The second area that still needs a great deal of work is the manipulation, mainly in embryos, of an organism’s genetic code. This is already being done in many species, such as bacteria, viruses, yeast, frogs, chickens, pigs, monkeys, and mice. Researchers and scientists can change these organisms’ genes at the embryonic stage with great ease, so that the resulting organisms will have specific features. Through such manipulation, scientists strive to achieve a better understanding of various underlying biological and metabolism-related principals. This is not done extensively in human embryos, nor is it totally banned. For example, in vitro fertilization involves separating human eggs that are defective in their mitochondrial DNA from their mitochondria and replacing them with normal ones. Although the resulting embryo’s genomic DNA is unchanged, its mitochondrial DNA is replaced. This can be considered genetic manipulation to some extent. This leaves two questions: Will we allow the genetic manipulation of human embryos? Does this mean creation to some extent? Let’s assume that a couple cannot have a healthy child because of a serious illness. You can try to convince this family that they should forego having a baby, since the genetic manipulation of human embryos is banned. In the case of genetically inherited severe illnesses or some pre-birth vaccinations against AIDS, genetic manipulation of the eggs or the embryo can be a powerful method in the future. But there are consequences.

Consequences

First, right now we do not have the necessary technology to guarantee completely safe genetic manipulation. But since technology develops incredibly fast, we might be able to do so within the next decade. We should use this time to prepare answers to the ethical questions and developments that are sure to arise. Second, although this technology will be developed primarily for disease control and prevention, some will use it to manipulate an embryo’s physical or mental properties, such as increasing its mental power or changing its eye color. Of course, this technology will be available only to rich people first, which means that their children will be more skillful. This can be considered unethical, but is it really all that different from rich people using already existing specific drugs or surgical techniques that they can afford? Third, does this mean “creation” to some extent? It does not, for the scientist is only manipulating the existing genetic code so that it will assume another form in the other already-existing recipient. Even if these are new codes, they still coded by the same general principal that was created by the ultimate Creator.

Conclusion

As technology develops, it brings new ethical questions to the fore of the public consciousness, as well as new ways to increase our knowledge of how the universe works. Molecular biology and genetics are important branches of science that develop quicker than many others. All such developments, regardless of field, should be explained to the public clearly to avoid misunderstanding. We do not need to see a repeat of what happened after Dolly’s clone was introduced to the world.

References

• http://www.sciam.com/explorations/030397clone/030397/beardsbox.html.
• Lodish, Harvey et al. Molecular Cell Biology. New York: Scientific American Books, 1986.
• Lewin, Benjamin. Genes VI. New York: Oxford University Press, 1997.