Many animals would tell us fascinating stories about their behaviors and marvelous abilities if only we could understand their language. As a result of years of research, many outstanding features of different animals have been discovered by scientists and these findings have formed the basis for numerous inventions. The Pacific golden plover (or the kolea, as it is called in Hawaii) is one such animal that is created with amazing abilities, like conserving huge amounts of energy with incredible techniques.

The Pacific golden plover is a migratory bird. The mother and father birds leave their nests in Alaska when their chicks are only a few months old, and return to Hawaii where they are originally from. Chicks by then have not yet learned how to fly [1]. After spending the summer in Northwest Alaska [2], when the winter comes chicks take off en route to the Hawaiian island where their parents are and where they have never been before. Considering that the distance is 4500 km (~2800 miles), this journey seems almost impossible for such a small bird, which, unlike many birds capable of trans-oceanic migrations, cannot swim, soar, or glide and weighs approximately 130 grams (~4.6 ounces).

Flying over the Pacific Ocean all the way from Alaska, the most extreme point of North America, to the island of Hawaii, the golden plover does not have a chance to land even for a short time to gather energy. The bird absolutely cannot fall under 130 grams either, because under this weight it would not have the energy needed for the remaining distance, which would be the end for the bird. To complicate matters even more, the Pacific golden plover loses 0.6% of its body weight every hour that it flies non-stop. There are two significant problems in this long journey; the fact that it cannot gain energy during its flight, and the problem of navigation. Not knowing which direction to fly in the vast ocean, or flying in the wrong direction for a short time, means an inevitable death for the bird.

The information we have obtained about this bird’s amazing ability to conserve energy journey is amazing. The flight time is 88 hours, or three days and four nights. For comparison, a modern Airbus A380 or Boeing 777-200LR can only fly about 18 hours without refueling [3]. During the flight, the Pacific golden plover flaps its wings 250,000 times, setting another record. “Imagine” says Dr. Oscar Wally Johnson from Montana State University “that flight you made from L.A. to Honolulu – only without the plane” [4].

Observations that have been made during the bird’s flight help us to understand how it overcomes these challenges [5]. The birds prepare for their journey by eating a lot and gaining a lot of weight in a short time. An average golden plover weighs roughly 130 grams and gains 70 grams of more weight, more than half of its body weight, during this intense eating period. Imagine a person that weighs 176 pounds (80 kg) gaining 100 pounds (45 kg) more to become 125 kg (275 pounds) in two weeks. The bird would normally lose 0.6% of its weight every hour it flies without a rest, and at the end of 88 hours it would remain only 117.8 g. As mentioned above, should the bird fall below its regular weight of 130 grams, it would be too exhausted to complete the journey. As soon as the bird runs out of energy, it would still have more than 497 miles (800 km) left before it reaches its destination. So, how is this problem solved?

If we want to save money on long car drives, then we set our cruise control to 110 km/h (~68 m/h) and drive at a constant speed. The bird does just that, and flies the whole distance at a constant and optimal speed of 51 km/h (~ 32 m/h) [6]. Flying slower than this speed would increase the amount of “fuel” that would be consumed, and flying faster would increase the energy consumption due to air resistance. Pacific golden plovers also fly in a “V” formation where the foremost birds flap their wings thus generating airflow that allows the birds in the rear of the formation to not have to use their wings in order to conserve energy [7]. Birds that are tired in front of the formation change their position with the ones who have had some rest at the back. Thus, they save about 23% of their energy and reach their destination of Hawaii while being slightly overweight. This excess weight is not stored in vain; it is estimated that more energy will be consumed in the case of bad weather conditions. During their flight, it is possible that the air could be foggy, cloudy, very sunny, or even rainy and windy, in which case their energy consumption can increase.

How does this bird determine the direction it should go? Imagine that this bird flies in absolute darkness for three nights without getting lost despite the fact that even a small deviation from their path could cause a huge deviation in the long run and cost the bird a fortune. They keep their flight formation and reach their destination despite all kinds of difficult conditions, including rain at night. With the help of a compass miraculously placed in the brains and eyes of these birds [8], they follow the magnetic field lines of the earth at a certain angle, adjust their position and follow their paths without facing any surprises [9]. Some scientists believe that the magnetic field map of the world is recorded in the eyes of migratory birds.

Migratory birds can also use the sun to correct their flight path. This difficult journey is successfully completed with the immigration program embedded into their genetic code by the Almighty Creator.

With their excellent energy saving and navigation features, the Pacific golden plover, a migratory bird species that has been doing this long-distance journey for thousands of years, provides us with very important lessons that can lead us to deep contemplation.

 “Have they never considered the birds above them, flying in lines with wings they spread out and fold in? Nothing holds them up except the All-Merciful. He indeed sees everything very well.” Mulk 67:19

References

1. If animals could talk-Wenn Tiere reden könnten Werder Gitt, K.-H.Vanheiden
2. https://academic.oup.com/auk/article-abstract/100/3/607/5185692
3. https://de.statista.com/statistik/daten/studie/232416/umfrage/reichweite-der-airbus-modelle/
4. https://hanahou.com/7.6/flight-of-the-navigators
5. https://www.nabu.de/tiere-und-pflanzen/aktionen-und-projekte/birdwatch/index.html
6. Peter F. Major, Lawrence M. Dill: The three-dimensional structure of airborne bird flocks. In: Behavioral Ecology and Sociobiology Band 4, Nr. 2, 1978, S. 111–122.
7. Cutts, J. Speakman: Energy savings in formation flight of pink-footed geese. In: J. theor. Biol. Band 189, Nr. 1, 1994, S. 251–261.
8. https://www.weltderphysik.de/thema/hinter-den-dingen/wie-finden-zugvoegel-den-weg/
9. https://www.spektrum.de/frage/orientierung-wie-finden-zugvoegel-ihren-weg/1425607

The parable of those who take to them other than God for guardians (to entrust their affairs to) is like a spider: it has made for itself a house, and surely the frailest of houses is the spider’s house. If only they knew this! (Qur’an, 29:41)

A prehistoric Greek fairytale says a young girl named Arachne was a superb spinner and knitted the most gorgeous cloth. She dared the goddess Athena to a competition. When Athena saw Arachne’s stunning work, she ripped the cloth and hit the young girl. Disgraced, Arachne committed suicide by hanging herself. Athena regretted and transformed Arachne into a spider, so that she could whirl repeatedly and endlessly. Arachnida is the scientific name for spiders. It comes from the young girl in the famous Greek fairytale.

Although usually feared and disliked by people, spiders in fact make life easy for us by feeding on mosquitoes, flies, and locusts, thus saving our crops and eliminate the need for man-made insecticides which pose environmental problems. Besides, spiders are much less dangerous than people think they are; most spiders are keen to avoid interaction with people and will bite only when wounded or scared. Even poisonous spiders are rarely as dangerous as popular myths would have us believe: though black widows are poisonous, and their bites painful, they rarely kill people. If handled properly and quickly the adverse consequences of a black widow’s bite typically diminish in a few hours, and, after a couple of days’ rest or cessation of activities, the victim will fully recuperate [1].

There are countless features of spiders. But their silk is exceptionally unique and this article covers its various aspects.

Spider silk

Biomaterials, having developed over millions of years, frequently surpass man-made substances in their properties. Spider silk is an exceptionally stringy biomaterial which is made almost completely of substantial proteins. Silk fibers have stretchy powers similar to steel and some silks are practically as elastic as rubber on a weight-to-weight basis. In uniting these two properties, silks disclose a hardiness that is two to three times that of artificial fibers like Nylon or Kevlar. In addition, spider silk is also antimicrobial, hypoallergenic, and completely biodegradable [2].

The power of spider silk, so fragile in manifestation, is astonishingly great. A filament can be outstretched as much as one half its normal length before breaking, and has a tensile strength exceeded only by fused quartz fibers. Fine fibers are sturdier than others, the power to some degree depending on the velocity with which they are pulled out of the spider’s body. The higher the speed, the superior the strength.

Most of the silken fibers are not single fibers but are made up of two or more strings. A thread may be as fine as a millionth of an inch in width but, frequently, it is ten or twenty times as dense, and the assemblage of these threads unsurprisingly creates larger threads of a diversity of thicknesses. Furthermore, some threads are gluey whereas others are not.

Scientific research demonstrates that a single thread of spider silk, thick as a pencil, could stop a 747 Jumbo Jet in flight, and that on an equivalent footing, the spider’s silk is stronger than steel, per unit weight. It has been shown that the dragline silk of the golden orb spider is one of the planet’s hardest threads.

Spiders employ silk for webs, but also for trap lines, draglines, ballooning lines, for egg pouches and nursery nets, for compartments in which to sleep through winter or to copulate, and for entrapping and wrapping their victims. Silk for all these objectives is not accomplished with one kind of gland; there are at least seven distinct kinds. A few distinctive spiders have as many as six kinds and probably have more than six hundred independent glands; others have fewer than this [1].

Mechanism behind the formation of spider silk

A batch of scientists headed by researchers from the RIKEN Center for Sustainable Resource Science (CSRS) have scrutinized spider silk and discovered that a formerly undiscovered organizational constituent is critical to how the proteins form into the beta-sheet conformation that gives the silk its extraordinary power [3]. If humans can cultivate equivalents to spider silk, they could be applied in industrial and medical applications. It is well-known that the beta-sheets in spider silk are significant to its strength, but how the sheets are created is scantily comprehended, making it difficult to produce synthetic variations. It is hard to comprehend the process: the silk is originally produced as soluble proteins, which very swiftly crystalize into a solid form.

To explain this, the CSRS scientists obtained silk proteins using genetically altered bacteria that can generate silk from a golden orb-web spider (Nephila clavipes) and then executed multifaceted examinations of the soluble proteins. They discovered that the reiterating area is comprised of two designs – unsystematic spirals and a design called polyproline type II helix. Their investigations confirmed that the polyproline type II helix is critical for the creation of the stiff construction, which can then be rapidly converted into beta-sheets, letting the silk be swiftly intertwined. Fascinatingly, it was discovered that pH – which is supposed to be significant for the molecular exchanges of the N- and C- terminus areas – does not play a significant role of the foldup of the recurring areas, and that it is rather the elimination of water and mechanistic forces through the silk gland.

According to Keiji Numata, who is a project leader of JST ImPACT and led the research group, “Spider silk is a wonderful material, as it is extremely tough but does not contain harmful substances and is readily biodegradable, so it does not exert any harmful load on the environment” [4]. Numata hopes that this discovery may lead to the production of artificial silk that will prove useful for society.

Analysis of silk

The silk itself is a material identified as a “scleroprotein.” When created in the glands it is a fluid; only when dragged outside the body does it solidify into thread. Once it was believed that contact with air produced the toughening, but it currently looks that the drawing-out activity alone is accountable for the change.

To carry out the exertion done by the glands, a spider is armed with spinnerets, usually six in number. These are as accommodating as fingers; they can be prolonged, compacted, and overall be applied like human hands. In the “spinning field,” where the spinnerets are congregated, single threads are joined into numerous compound threads, and some of the dehydrated threads may be covered with a gluey substance. Thus, a completed thread may be thin or thick, dry or sticky. It may also have the look of a bead-trimmed necklace. For the last kind, the spider spins rather unhurriedly and, drawing out the gluey thread, lets it go with a jolt. The liquid thus is organized in beads spread out lengthwise across the completed line.

The strand known as the dragline may be understood as a spider’s “life line” because it performs as a lifeguard in all kinds of situations. The dragline goes along with the spider, no matter where or how far it journeys, winding out from spinnerets at the back of the body. It forms a portion of the building of webs, it grips its tiny builder firmly in problematic places, and it helps in absconding from adversaries. When a spider is inactive in a web, the dragline enables a rapid descent and escape. It allows energetic chasing spiders to jump from buildings, cliffs, or any tall position with absolute security. [1]  

Benefits of spider silk to us

The silk of the silkworm could be very profitable and marketable. There are, however, challenges. One is the changing thickness of a spider’s strand; the other is that it doesn’t well endure the interweaving process. Housing and feeding large numbers of silkworms is not difficult. But housing and feeding large numbers of spiders? There are enormous difficulties.

Native inhabitants of New Guinea have used spider silk in a variety of conditions. They make fishing nets, traps, and such objects as bags, headdresses that will keep away rain, and caps. These are not formed from single threads but from tangled, warped threads. The aboriginals of North Queensland, Australia, look to spiders for their angling supplies.

Spider silk has been valuable to the manufacturers of such complex instruments as astronomical telescopes, guns, and engineers’ levels. The threads, being exceedingly fine but nonetheless robust, are outstanding for sighting marks. Throughout the Second World War, there was a significant demand for spider thread for surveying and laboratory instruments. Black widow spiders were utilized for the manufacture of this silk.

One drawback to the use of spider silk in industry is that it might slump in a moist environment. To overcome this problem, strands of platinum or etching on glass plates take its place in such instruments as periscopes and bombsights. [1]

Spider’s silk also might have healing properties. Due to its antibacterial properties and because the silk is abundant in vitamin K, it may be efficient at clotting blood. Because of the problems in obtaining and handling extensive amounts of spider silk, the largest known piece of cloth made of spider silk is an 11 by 4-foot (3.4 by 1.2 m) fabric made in Madagascar in 2009. Eighty-two persons labored for a period of four years to gather over one million golden orb spiders and extract silk from them. [5]  

Applications of spider silk

As mentioned, human beings have been using spider silk for thousands of years.

The manufacture of contemporary synthetic super-fibers such as Kevlar (bulletproof material) includes petrochemicals, which adds to pollution. Kevlar is also strained from concentrated sulphuric acid. In comparison, the manufacture of spider silk is totally ecologically sustainable. It is created by spiders at ambient temperature and pressure and is strained from water. Furthermore, silk is totally biodegradable. If the manufacture of spider silk ever becomes industrially practical, it could be a substitute for Kevlar and be used to create a varied extent of articles such as: bulletproof vests, wear-resistant lightweight clothing, ropes, nets, seat belts, parachutes, rust-free boards on motor vehicles or boats, biodegradable bottles, bandages, surgical thread, artificial tendons or ligaments, and backings for weak blood vessels. [6]

Synthetic spider silk [5]

Duplicating the multifaceted settings needed to make threads that are similar to spider silk has been difficult to both research and manufacture. Through genetic engineering, Escherichia coli bacteria, yeasts, plants, silkworms, and animals have been utilized to produce spider silk proteins. Yet, these synthetic threads have diverse, simpler features than those of a spider. Manmade spider silks have lesser and unsophisticated proteins than natural dragline silk, and have subsequently half the diameter, strength, and flexibility.

One tactic is to remove the spider silk gene and utilize additional life forms to generate the spider silk. Canadian biotechnology company Nexia effectively produced spider silk protein in transgenic goats that passed the gene for it; the milk made by the goats comprised noteworthy amounts of the protein: 1-2 grams of silk proteins per liter of milk. To make spider silk, Nexia utilized damp whirling and pressed the silk protein across minor extrusion cavities in order to mimic the performance of the spinneret, but this process was not adequate to duplicate the sturdier characteristics of innate spider silk.

In March 2010, investigators from the Korea Advanced Institute of Science and Technology was able to produce spider silk by means of the bacteria E. coli, altered with definite genes of the spider Nephila clavipes. This tactic removes the necessity of milking spiders.

It should be noted that the manufacture of spider silk is not easy and there are intrinsic difficulties. First of all, spiders cannot be cultivated like silkworms since they are flesh-eaters and will merely eat each other if in proximity to each other. The silk produced is very slight, so 400 spiders would be required to make only one square yard of cloth. The other problem is, silk also toughens when subjected to air, which makes working with it problematic.

A different tactic is to study how spiders whirl silk and then replicate this process to make artificial spider silk. The silk itself would also have to be synthetically produced. Chemical production of spider silk is not feasible at present due to the absence of information about the makeup of silk. Randolph V. Lewis, Professor of Molecular Biology at the University of Wyoming in Laramie, has introduced silk genes into Escherichia coli bacteria so that the recurring sections of spidroin 1 and spidroin 2 efficaciously come to form. Others theorize about the likely gene introduction into fungi and soya plants. It may also be possible to modify the silk genes for precise intentions.

Why a spider’s house is the frailest of houses

Spider silk is stronger than steel, but the Qur’an (29:41) states that the flimsiest of houses is the spider’s house. The per unit weight of the dragline silk of the golden orb spider is one of the world’s hardest fibers. Webs are combinations of many kinds of spider silk, all able to be produced by the same spider. The web radials are strong, but the somewhat feebler circumferential (quasi-circular concentric) fibers are flexible and gluey to absorb the energy of a flying insect and hold it in place. The strongest of all is the fiber, which the spider uses for transport, the dragline silk. In summary, the spider fabricates both sturdy as well as feeble fibers and the web it weaves to catch flying insects is weaker; this may be the reason why it is referred to in the Qur’an as the “frailest” of houses.

Conclusions

Scientists are foreseeing many potential uses for biosilk. Textile usages are noticeable one. The flexibility and potency of prevailing merchandises such as spandex and nylon have to be improved. Since it is lightweight, hardy and flexible, biosilk may also have uses in satellites and aircraft. More prominently, the new group of progressive things that spider silk investigation may cause has the prospective to alter our lives in innumerable manners that we can barely imagine. More than 72 years have passed since the inventions of Wallace and Carothers that gave the world nylon that led us into the age of polymers. Artificial spider silk may help produce super-performing clothes of the future. Earthquake resistant suspension bridges hung from cables of synthetic spider silk fibers may someday be a reality. [1]

References

1. Syed, I. B. : Spider Silks http://www.irfi.org/articles/articles_1_50/spider_silks.htm
2. Romer, L and Scheibel, T.: The elaborate Structure of spider silk, PRION, Oct-Dec. 2(4) 154-161, 2008. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658765/
3. RIKEN Center for Sustainable Resource Science (CSRS). Scientists discover key mechanism behind the formation of spider silk. Materials Science. May 29, 2018, https://phys.org/news/2018-05-scientists-key-mechanism-formation-spider.html

4. Nur Alia Oktaviani, Akimasa Matsugami, Ali D. Malay, Fumiaki Hayashi, David L. Kaplan, Keiji Numata, “Conformation and dynamics of soluble repetitive domain elucidates the initial β-sheet formation of spider silk”, Nature Communications, 10.1038/s41467-018-04570-5 https://en.wikipedia.org/wiki/Riken
5. Service, Robert F. (18 October 2017). “Spinning spider silk into startup gold”. Science Magazine, American Association for the Advancement of Science. Retrieved 26 November 2017. https://en.wikipedia.org/wiki/Spider_silk
6. Vivienne Li, University of Bristol, Spider Silk and Venom. Molecule of the Month – July 2002. http://www.chm.bris.ac.uk/motm/spider/page4.htm

Around 4–5 billion years ago (bya) my formation began from the remaining matter after the creation of the sun. In time, this matter accumulated and formed the small planetary objects (planetesimals) which were the earlier forms of future’s giant planets. Our collisions continued with the planetesimals that orbited the sun. As a result of these continuous collisions and bombardments, my surface temperature raised to almost 6,000oC. What I am trying to say is that I was an enormous globe consisting mainly of metallic substances that were melted in boiling lava and showered by thousands of meteoroids and comets. God the Creator has hidden many messages of mystery regarding the entire process I endeavored for humans to discover.

When I began to cool down, my surface hardened like a shell, and because I was not yet sufficiently protected by the gaseous shield known to us today as the atmosphere, my shell was destroyed by the ceaseless continuation of the meteoroid bombardment as soon as it began to form. This transformation continued for billions of years. At last when the invasion of the meteoroids began to ease, I started to mature and slowly began the process of cooling down.

4.4 billion years ago

The creation of pieces of land that looked somewhat different than the seven continents at the present began. They were just sections of land floating on my coat of crust. The formation of crust around my surface was subjected to rupture due to the high pressure caused by the intense heat deep down inside me. Over a period of time this crust, which separated into a number of huge fragments (plates), experienced various deformations that resulted in the formation of mountains. This is how the basins of the ocean and the contours of the continents began to emerge. This was the period during which new specimens of rock (granite) and the floor of the ocean (basaltic), consisting of rising magma, formed the core of the continents. Today scientists are studying the oldest granites (billions of years old) that have managed to survive natural disasters and destruction to discover how the first continents were actually formed.

Granite is the rock that forms the cores of the continents (cratons). Cratons are produced by the primary component of the oldest crust. Cratons are light enough to float on my coat of crust; they are a system created in a way that enables the development of continents. These cratons are found especially in central parts of Africa and also in South America, Australia, North America, and Scandinavia.

My surface is made up of integrated fragments called tectonic plates. Even though my crust was created by rock, it was created flexible enough to allow the plates to move a few centimeters every year caused by the intense heat from beneath my surface.

Continents

Ground movement and various changes have occurred over time due to the dynamic structure of the continents and plates attached to the mantle. Discoveries of exactly the same fossils and identical fresh water organisms in two completely different continents far from each other have proved this. The actual reason for the plate’s activity is that my core is much higher in temperature than my surface. The core deep inside me is around 5,500oC. The greater portion of this intense heat occurred in my early days as a result of the collisions and bombardments I faced, and the remaining is related to the disintegration of the radioactive elements which settled particularly in my mantle section. The heat waves which spread from my core were passed on to the next layer of the mantle. The heat melted a section of my mantle layer and magma forced my molten rocks to the surface. The molten rock, which fills the spaces between the cracked plates, enables new rock to develop, and then the plates separate from one another.

Around the same period of the formation of new rocks, my plates and the continents found on them separated. The formation of rocks deep within ocean continues the creation of the range of volcanic mountains even today. The range of under-water mountains continues for about 12,000 miles between the Antarctic and the North Pole and rises above sea level in some places.

The region called Iceland between the North American and Eurasian plates was formed as a result of an enormous volcanic eruption. This is one of the few places where the separation of the continents is clearly visible. The crevasse of Iceland, surrounded by the American plates on one side and the other European plates on the other, is around 3 miles in width. This crevasse is increasing with the formation of new rocks and is expanding the distance between America and Europe. Scientists say that the distance between the continents is increasing by around 1 inch every year, so within a hundred years the distance between America and Europe is expected to increase another 8 feet.

3.4 billion years ago

The main continents were forced together by movement of the tectonic plates forming new continents, and there are still remaining pieces of these continents inside the cratons of Australia and Africa.

2.7 billion years ago

My first super continent is still the ruling territory. But due to the power built up by heat emerging from my core, the tectonic plates are on the verge of separating this continent. Because of the heat from my core, the main land has separated and oceans were formed in my surface. Today these oceans do not exist on my surface anymore; but you can still find their pieces in the continents by a careful look.

1.1 billion years ago

The supercontinent called Rodinia, a continent which contains most of the earth’s landmass, was created. Seven hundred and fifty million years ago (mya), the heat from my core began to break down this supercontinent, and as a result Rodinia was destroyed and a new supercontinent called Pangaea, the origin of all the continents known in the present day, was created.

Two hundred million years later (or five hundred and sixty-five mya): I became acquainted with bacteria, funguses, poriferans (sponges), earthworms, mollusks, segmented worms, and arthropods.

During the time when these creatures lived on me, the climate was moderate. Major volcanic activities occurred during this period when most of the land was covered by shallow seas. The sudden outbreak of the thousands of species of living creatures during this period may seem amazing to you; in fact, this was actually the first period in which complex structural vertebrates were created.

495–435 million years ago

I first became associated with the red and green sea algae. This was also the period in which various fish and sea creatures were created. The enormous landmass of this period called Pangaea gave me a totally different appearance and had a huge impact on the climate. The reason for this was that a large section of the land was so distant from the sea. The climate of the inland regions was showing deep scale signs of change with every season-certain periods of the year were very hot and others considerably cold. During this time, the ocean did not have the effect on the climate like it does today. This is why the climates varied to such an extent. The change of climate played a huge role in the extinction of many species of that period and destroyed almost 90% of the living creatures.

Creation has continued at a distinct magnitude during the millions of years that have passed, and between 270–340 mya larger proportioned variations of vegetation were created. In a short space of time, this vegetation formed into giant trees that covered huge areas of land. The largest deposits of coal were created from the fossilization of these trees, an example of creation that would make your life a little easier in the years to follow.

On the other hand, the territories began to gather together close to the planes of the equator, and this vast land was covered with rain forests resembling the Amazon. These immense lands of greenery were the marshy forests that were home to extinct ferns and the first seeds of the various groups of plant life. The inhabitants of this intense vegetation were mainly insects, centipedes, and scorpions, but much larger than the ones we know today. The plants and forests disappeared suddenly at the end of this period, and towards the end of the same period when the vast lands of Pangaea began to take form, the glaciers expanded, the sea water receded, and the arid climate changed dramatically along with the forestry structure and vegetation. Then the creation of many new creatures occurred.

250 million years ago

The supercontinent Pangaea began to break up, and this separation caused the formation of Gondwana in the northern hemisphere and Eurasia in the south. Throughout the millions of years, South America began to recede from Africa while North America receded from Europe, resulting in the formation of the continents as we know them today. Australia drifted from the Antarctic continent and moved slowly towards more moderate climates. The evolution of the continents continued to form the huge canyons and valleys in America, and the vast range of mountains, including the Himalayas and the Alps. Between 225–190 mya mammals were created, and between 190–135 mya, birds and alga were created, followed in the next period by plantation seeds which almost completed my preparation as a suitable place for you all to live.

100 million years ago

The plan of the present day continents became apparent. Sometimes my land masses would collide in the regions where the plates joined and caused activity like the formation of the mountains. Without this plate movement, there would have been no mountains created on the planet. During this period, the various species of dinosaurs and reptiles became extinct for reasons unknown to humans. Throughout the following 100 million years, the creation of the most significant mountain ranges, like the Himalayas, occurred along with the continuing collisions of the continents. These plates continue to move 5–10 cm every year and still cause collisions today.

Today I am the proud owner of seven continents. Africa-Eurasia is an enormous supercontinent which houses Africa, Europe, and Asia. Beginning from the plateau of Siberia in Russia, it reaches as far as Africa, but Africa-Eurasia is not my only supercontinent. North and South America joined by Panama also have vast territories. If the Bering Strait that separates Russia and Alaska were to freeze, a person who set out from South America could walk as far as South Africa covering a total distance of 25,000 miles.

Although you are may not realize it, the activity of the continents continues today, and my existence that began billions of years ago will continue in the future until the time comes for me to die (you call this doomsday).

There is another aspect of the continental activity that affects you. This occurs in the form of disasters, for instance the earthquake, an event of nature which has occurred for millions of years. This activity of creation occurs as a result of the intersection of the plates, the collision of continents, or the ocean plates submerging beneath the continent. The tsunami disaster in Indonesia in 2004 was the result of a catastrophic movement of these plates.

The exceptionally lengthy process of my creation explains the transformations and progress I have experienced until I reached the condition suitable for the most precious and honorable of all creation: human beings. I hope that every moment and every aspect of the manifestation of science, wisdom, power, and willpower of my life story and creation will be a guide for you in the future and will encourage you to be even more curious about my end and to bow to our Almighty creator in respect of all He created.

The second leading cause of death in the United States, after heart diseases, is cancer, claiming around half a million lives every year.(1) People today are concerned more than ever about cancer and its terrible consequences. However, in the light of recent scientific findings, a very different picture can be seen: In an environment with increasing carcinogens, it is actually surprising to find most populations are cancer-free. This is because our bodies are equipped with systems to prevent cancer formation.

Cancer research over the last two decades has shown that cancer is a disease of the genome.(2) Changes in the DNA, called mutations, disrupt the regular cellular networks that control a state of delicate balance. People are continuously exposed to varying amounts of chemicals that have been shown to cause mutations in the genome which may lead to cancer formation. Exposure to harmful chemicals can occur due to being in an environment where these agents are present in the food, air or water, and also due to our own metabolism which may produce these chemicals. It has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the formation of the majority of human cancers.(3)

Even though some of the mutations caused by these agents hit cancer-critical genes, cancer does not immediately develop. Furthermore, cancer is mostly seen in old age, when many mutations have accumulated in the genome. The reason why we are protected from developing cancer, even though our DNA is under numerous types of attacks everyday, is that our cells are equipped with several lines of defense against cancer formation. These built-in defenses include DNA damage repair systems, external and internal controls of cell division rate, and the programmed death of cells. All of these defenses have been given to our cells in order to protect us from getting cancer. If we were not to have these defenses, cancer would be a daily occurrence for every one.

It is possible to say that a cell’s first defense against cancer is similar to the regular maintenance of a car. One has to replace the brake pads, change the oil, etc., so that the aging of the parts will not cause failure that may lead to an accident. Similarly, chemical carcinogens from environmental pollution, ultraviolet rays from the sun, radiation from various sources, etc. all cause multiple types of damage in the DNA molecule. Therefore, our cells and genome need maintenance as well. This function is carried out by groups of proteins called DNA repair complexes. DNA repair mechanisms have been designed to correct the DNA damage before it can lead to inheritable mutations.(4)

If the DNA damage repair systems are intact, most of the damages to the genome are dealt with before they can cause problems. We observe the extent of attacks that can damage the DNA on our genome in many types of cancer where the DNA repair mechanisms are known to have been inactivated. In these cancer cells, mutations accumulate at a very fast rate, leading to more aberrant behavior. Also, individuals with defective DNA repair systems are more susceptible to developing various types of cancer.(4,5) Therefore, the first line of defense given to our cells against cancer is the ability to check and correct the integrity of our genome.

Every cell type in our body has been designed to proliferate at a certain rate that is suitable for the function of those cells. For example, neurons or muscle cells almost never divide after reaching adulthood, whereas the epithelial cells lining the interior of the intestines or under the skin divide at a fast rate continuously throughout our lives. The rate of division of a cell is mainly controlled by extra-cellular cues, i.e. a normal cell doesn’t grow or divide unless it receives growth and proliferation signals from neighboring cells.

There is a safe rate at which a cell must divide – just as a car needs to be driven at a safe speed. The requirement of cells for external stimuli in order to grow and divide is like the car’s need for someone to step on the gas pedal in order to accelerate. Normal cells cannot grow without control as neighboring cells produce growth signals when they are necessary and stop producing them in a regulated manner. A good example of the control of cell proliferation rate is seen in the wound healing process. When there is a cut in the skin, the cells adjacent to the wound are stimulated to divide rapidly by signals given from the injured cells; they divide and close the wound as soon as possible. However, when there are no wounds, there is no signal to divide and the skin cells only divide at a very slow rate, just enough to replace dying cells; this is a much slower process than wound healing. Cancer cells, on the other hand, are known to produce their own growth signals and proliferate abnormally fast and in an uncontrolled manner.(6) Therefore, the environmental control of cell division is an important barrier against cancer formation.

Cancer cells cannot divide uncontrollably unless they are independent of the external stimuli to divide. However, cancer cells can produce their own growth and proliferation signals, so they are free from external constraints. But even then, all is not yet lost. This situation of uncontrolled and rapid cellular proliferation is like a car in which the accelerator has become jammed– the car accelerates continuously and an accident is impending. In this situation the way to prevent too much speed is to step on the brake of the car. Similarly, in a cell, there are a set of genes called tumor-suppressor genes, which are responsible for stopping cell division upon excessive growth stimuli.(7) These genes act like brakes in cell division and prevent further progression into a malignant state. In many cancers,(8) it has been shown that these genes have been inactivated. If the brakes of the car are functional, you can safely bring your car to a stop and fix the problem that caused the accelerator to jam. Similarly, if a cell starts to divide too rapidly, it can stop dividing and repair the damage that caused the uncontrolled growth. Therefore, tumor suppressor genes represent a third line of defense.

If all the previous safety valves fail, there is one more defense to cancer. A situation in which a cell with harmful mutations promotes its own proliferation and cannot abort the division process is similar to one where the accelerator of the car is jammed and the brakes don’t work. In this case, in order to prevent greater damage, one can choose to hit a wall or a tree to stop the car– this will total the car, but will prevent further damage to others. Similarly, if a cell begins to grow uncontrollably and can’t slow down its rate of division, a process called apoptosis, or programmed cell death is initiated. In apoptosis, the cellular DNA and cellular compartments, like lysozomes, Endoplasmic Reticulum, and Golgi are degraded, and the cell shrinks in size. In the end, the cell dies and is absorbed by neighboring normal tissue. Therefore, the programmed death of an aberrantly behaving cell is another way that the body is protected from cancer. As expected, in cancer cells defects in this last line of defense are observed as well.(9)

These four mechanisms, i.e. DNA repair, external/ internal cell division suppression, and programmed cell death, are only the ones that we are aware of at this time. In addition to these, there are multiple levels of other redundant safety checks. All these safety features work without our knowledge or will. Findings from cancer research show that the design of cells was carried out so intelligently that even the carcinogenic environment which we produce today was accounted for within the genes of the very first human being.

Notes

1. Cancer Statistics 2006. 2006, American Cancer Society.

2. Vogelstein, B. and K.W. Kinzler, “The multistep nature of cancer.” Trends Genet, 1993. 9(4): p. 138-41.

3. Wogan, G.N., et al., “Environmental and chemical carcinogenesis.” Semin Cancer Biol, 2004. 14(6): p. 473-86.

4. Dixon, K. and E. Kopras, “Genetic alterations and DNA repair in human carcinogenesis.” Semin Cancer Biol, 2004. 14(6): p. 441-8.

5. Jiricny, J., “The multifaceted mismatch-repair system.” Nat Rev Mol Cell Biol, 2006. 7(5): p. 335-46.

6. Brattain, M.G., et al., “Growth factor balance and tumor progression.” Curr Opin Oncol, 1994. 6(1): p. 77-81.

7. Hanahan, D. and R.A. Weinberg, “The hallmarks of cancer.” Cell, 2000. 100(1): p. 57-70.

8. Coleman, W.B. and G.J. Tsongalis, “Molecular mechanisms of human carcinogenesis.” Exs, 2006(96): p. 321-49.

9. Dlamini, Z., Z. Mbita, and T. Ledwaba, “Can targeting apoptosis resolve the cancer saga?” Future Oncol, 2005. 1(3): p. 339-49.