It has been over half a year since Covid-19 swept across the world and forced many countries into quarantine. Hopes of a quick resolution of the disease in many countries have since been, unfortunately, proven to be wrong, and it is evident that the virus is here to stay for a while [1]. The virus is so difficult to deal with considering it can be transferred from person to person even if the carrier does not outwardly display symptoms. Even animals, ranging from mice to tigers, can contract and transmit it to humans [2, 3], and we cannot quarantine or force them to wear facemasks. The virus will eventually hit each person; it is just a matter of time. The virus may additionally arrive in multiple waves, as it is possible to be reinfected [4]. COVID-19 will most likely have a lifespan of a few years, much like other major virus outbreaks of the past such as the swine flu in Hong Kong or Spanish flu. It will probably come and go like a common flu in never ending waves. So, each of us need to be ready until a successful vaccine is developed, and the wisest action for each person to be ready would be to boost our immune systems and practice effective social distancing and sanitation measures, while we deal with this virus for however long it may last.

Vaccines are critical for stunting the development and spread of viruses; however, they can be costly, time-intensive to develop, and not always perfect. It is worth exploring alternative methods to help protect our bodies from these pathological invaders while vaccines are being researched. As it so happens, the best method of prevention to date for HIV infections is not a vaccine, but is instead a tradition that is as old as thousands of years: male circumcision [5]. To give a comparison, the current widely popular and heavily promoted influenza vaccine is considered “50% effective against influenza B/Victoria viruses and 37% effective against influenza A(H1N1)” [6]. On the other hand, according to an article published in the prestigious medical journal, The Lancet, circumcision is up to 88% effective in preventing heterosexual transmission of HIV [7]. Male circumcision does not have any medicinal side effects, and the only risks that are involved are those related to any minor surgery – bleeding and infection.

In the 1980s, when I first heard of HIV, I remember reading articles which claimed, quite arrogantly, that vaccines and cures for the condition would be found within two or three years [8]. Forty years later, and after spending many billions of dollars on research, we are still nowhere near an HIV vaccine. At best, we found treatments which helped keep the HIV virus at bay [9]. To date, only two people have been fully cured with a method far too expensive to be applied to the general public [10]. In the meantime, at least 30 million people have died with more than half a million in the year 2019 alone [11]. While vaccines are critical for helping to eradicate viruses, putting all of our eggs into that basket alone can be a risky public health strategy due to how difficult and time consuming they are to discover, verify, and distribute. It is impossible to know for sure how long it will take to develop a vaccine for the coronavirus. In the meantime, communities should heavily consider following the instructions of their local health officials which often include social distancing, limited size gatherings, and frequent hand washing as these methods are already proven to help reduce the spread of the virus.

Development, and even the rushed development of a vaccine, is always a very tedious and dangerous process. The science behind them is exceptionally complex, and imperfect results can have disastrous consequences upon thousands of people. This is further complicated by the fact that phase 2 and phase 3 trials can have quite diverging results [12]. In the USA, AstraZeneca’s COVID-19 vaccine trials were stopped after trial participants fell ill [13]. Third phase trials, which encompass thousands of people [14], still can give little indication of the long-term side effects to any vaccine. Besides, even though there is human life at risk, the vaccine has already become an instrument for many political and economic disputes and conspiracy theories. Some governments claim they have already developed a vaccine, while others find them unreliable, or try to lure a foreign company to work for themselves [15]. In August of this year Russia rushed registration of an unproven Coronavirus vaccine and named it, in Cold-War-like fashion, the “Sputnik V” [16]. The announcement was made by none other than Vladimir Putin himself. It was offered to the USA, but was rejected due to safety concerns stemming from a belief that the drug was not adequately researched and developed [17]. In the meantime, Russia announced the development of a second vaccine [18]. Surely enough, it was dismissed and downplayed by the West as unproven and unreliable. On the other hand, a vaccine developed by a Chinese company Sinovac proved to be the most successful in its phase 3 trials in Brazil [19]. Sao Paulo Governor João Doria purchased 47 million shots of the vaccine. However, the transaction was stopped, arguably for political reasons, by the Brazilian President Jair Bolsonaro [20]. Bolsonaro’s comments when rejecting the purchase of the Sinovac vaccine on the basis that “the Brazilian people will not be anyone’s guinea pig” are not totally without merit. Recalls of “proven and tested” vaccines have happened in the past [21].

It is important for all people to continue exploring methods to develop their immune systems and prevent the spread of the virus while we wait for a vaccine. In an article I had previously published, I discussed the benefits of fasting, vitamin C, and Wim Hof breathing methods to help protect the body from disease [22]. All of these methods are well known and quite benign with respect to side effects, however they are unable to cure Covid-19 or prevent its spread. Additionally, the Center for Disease Control (CDC) has heavily stressed practices included social distancing and the wearing of non-ventilated face masks. Our hope is that going above and beyond to protect ourselves and our neighbors will give scientists the time that they need.

One way of giving that time to scientists is fasting. Fasting, like circumcision, is a tradition that is thousands of years old. In recent studies, a three-day water fast has been shown to reset the immune system of elderly people to the level of a twenty-year old’s [23]. At this current level of emergency in the world it would be very easy to find thousands of willing volunteers to trial monthly three-day water fasts and/or to take extra doses of vitamin C, not as a cure, but as a shield against COVID-19. This kind of study would not pose much risk and would definitely be very cost-effective. We could dive straight into the third phase of trials, for any side effects of fasting are already well known. And finally, if proven effective, its uptake by the population at large would be basically cost free and readily available across the whole world.

Our world has been enduring a difficult and challenging period for the better half of a year now. Time has given us the ability to learn more about the virus, how it disrupts our bodies, and how it spreads. This knowledge has, in turn, allowed us to research it and develop effective social guidelines for limiting its spread. Still, there is much work to be done. Hysteria and haste are not conducive to producing a vaccine that is thorough, effective, and efficient. It should be the responsibility of every able-bodied citizen to do what they can to learn more about how they can protect themselves from the virus and thus prevent it from spreading even more while we wait for a vaccine.

1. https://www.wuky.org/post/beshear-next-few-weeks-will-be-critical#stream/0
2. https://www.washingtonpost.com/science/2020/09/03/coronavirus-deer-mice-spread/
3. https://www.cdc.gov/coronavirus/2019-ncov/daily-life-coping/animals.html
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326402/
5. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(99)03421-2/fulltext?_eventId=login
6. https://www.aafp.org/news/health-of-the-public/20200226interimfluve.html
7. Halperin, D. T., & Bailey, R. C. (1999). Male circumcision and HIV infection: 10 years and counting. The Lancet, 354(9192), 1813-5. doi:http://dx.doi.org/10.1016/S0140-6736(99)03421-2
8. https://www.immunology.org/publications/bsi-reports/60-years-immunology-past-present-and-future/the-hunt-for-hiv-vaccine
9. https://www.cdc.gov/hiv/basics/livingwithhiv/treatment.html
10. https://www.medicalnewstoday.com/articles/2nd-person-cured-of-hiv-thanks-to-stem-cell-transplant
11. https://www.unaids.org/en/resources/fact-sheet
12. https://www.fda.gov/media/102332/download
13. https://www.usatoday.com/story/news/health/2020/09/09/covid-vaccine-astrazeneca-trial-hold-what-does-mean/5757590002/
14. cancer.org/treatment/treatments-and-side-effects/clinical-trials/what-you-need-to-know/phases-of-clinical-trials.html
15. 15 https://www.nytimes.com/2020/03/15/world/europe/cornonavirus-vaccine-us-germany.html
16. https://www.theverge.com/2020/8/11/21363135/russia-coronavirus-vaccine-unproven-registration
17. https://www.techtimes.com/articles/251792/20200814/covid-19-us-says-no-to-russias-vaccine-sputnik-v-saying-theyll-never-use-it-on-monkeys-let-alone-people-vietnam-and-philippines-say-otherwise.htm
18. https://abcnews.go.com/Health/wireStory/russia-approves-2nd-virus-vaccine-early-trials-73614460
19. https://fortune.com/2020/10/20/covid-vaccine-china-brazil-testing-ground-safest-most-promising-sinovac/
20. https://apnews.com/article/virus-outbreak-brazil-state-governments-health-sao-paulo-b7b5b620ba54f402dbf803e26fe6b842
21. https://www.cdc.gov/vaccinesafety/concerns/recalls.html
22. https://medium.com/@arasweb/surviving-the-pandemic-370b47120d8d
23. https://news.usc.edu/63669/fasting-triggers-stem-cell-regeneration-of-damaged-old-immune-system/

The human immune system responds to viral infections in two ways. The first is the innate immune system. It is the first line of defense in our body and the only one that exists in many multi-cellular organisms. It involves certain kinds of immune cells that recognize pathogens. These cells immediately attack and ultimately destroy the infection-causing microbes. One may find the classical video showing a macrophage engulfing a bacterial cell interesting (https://www.youtube.com/watch?v=JnlULOjUhSQ). However, the innate immune system is not specific and does not form a memory against infections.

The second and more specific type of immune system is called the adaptive immune system. As the name suggests, it is specific and can build immunity against certain kinds of infection. Compared to the innate immune system, it is slower, but its high specificity makes it a powerful defense mechanism. The adaptive immune system is present only in jawed vertebrates, as it requires several macromolecular systems, which are found only in more complex organisms.

One of the main parts of these complex molecular systems forming the adaptive immunity is called the antigen processing. This refers to the presence of small particles on the cell surface. This process requires the transportation of these antigens from the inside to the outside surface of the cell. The plasma membrane of the cell is semi-permeable to chemicals and small molecules. Only small, uncharged, hydrophobic molecules can diffuse through these membranes. However, antigens are usually small pieces of proteins that are charged. Therefore, the transport of antigens through the plasma membrane is not an easy task. This difficult task is done by a special transporter, called the transporter associated with antigen processing (TAP).

In order to transport antigens across the membrane, TAP uses adenosine triphosphate (ATP) as its energy source. For almost a half century, scientists tried to understand how these molecules transport their substrates across membranes [1]. Although biochemical studies have taught us a lot, there is still more to be discovered. Years of research resulted in different models that explain how TAP works and why it needs energy. A recent finding helped to shape the working model to its current form, while also explaining that very important question: why does TAP need energy?

The working model of membrane transport assumes that TAP has two main conformations [2]. In one of the conformations, the antigen binding site is open to one side of the membrane. In the other conformation, the binding site is open to the other side of the membrane. This allows the antigen to be transported from one side of the membrane to the other. However, one major question this model raises is why TAP doesn’t allow the antigen to leak back.

This would be a deadly issue if it was the case for the cell. We know that this does not happen, but we don’t know why it doesn’t happen. Scientists have been trying to tweak their models to fit a one-way transport mechanism.

The recent study mentioned above showed that TAP works in one direction only, confirming the predictions. The study also addressed why TAP needs energy, i.e., ATP hydrolysis. Energy is needed to ensure that the antigens do not leak back. This finding also makes sense when other transporters that do not need energy are considered, simply because they can work in both directions. In short, TAP uses energy only when it “swallows” the antigens to the other side of the membrane while making sure they don’t leak back.

The proper functioning of TAP is critical for human health. Genes encoding TAP have been shown to have nearly 100 single nucleotide polymorphisms (SNPs), the variations in the human genome. Some of these SNPs cause immune deficiencies in certain individuals or populations. These SNP studies further highlight the importance of TAP.

The story told above is taking place in our cells all the time. Even when we fall ill and rest in bed, the adaptive immune system and TAP fulfill their roles and help our body recover.

References

1. Jardetzky, O., Simple allosteric model for membrane pumps. Nature, 1966. 211(5052): p. 969-70.
2. Grossmann, N., et al., Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter. Nat Commun, 2014. 5: p. 5419.

HIV/AIDS is one of the most devastating health issues in modern history. Since the first case was reported in 1981, over 25 million people have died of HIV/AIDSrelated causes. Despite a better understanding of the disease, extensive knowledge about virus-human interaction, improved preventive measures, and medical treatment options, most experts agree that the pandemic is still in its early stages and rapidly spreading. According to the World Health Organization, in 2006 4.3 million people became infected with HIV and a total of 2.9 million people died of HIV/AIDSrelated causes. As of 2007, over 40 million people are living with HIV/ AIDS around the world and nearly half of them are females between the ages of 15 and 24.

With a vaccine still perhaps decades away, the best hope for impeding the spread of this deadly disease lies in effective prevention, early diagnosis, and successful treatment. For more than two decades, thousands of researchers from the most prestigious institutions around the globe have been struggling to discover more effective screening, diagnosis, and treatment options against HIV/AIDS, but a great deal has yet to be accomplished. At the moment, the high cost of the current medical treatment options and limited accessibility to HIV testing worldwide remain as additional obstacles to be overcome. Below is a table showing the spread of HIV/AIDS worldwide, based on the best available information provided by WHO in 2006. Additionally, the map below represents the regional distribution of adult HIV/AIDS cases by region based on UNIAIDS 2006 Report on the global AIDS epidemic.

What is HIV/ AIDS?

Healthy human bodies have a wellprogrammed defense mechanism (the immune system) that fights infections and helps prevent the development of cancer cells. Human immunodeficiency virus (HIV) primarily targets vital elements of the immune system, such as helper-T cells, macrophages, and dendritic cells. Due to the damage and destruction of these cells, the human body loses its ability to fight against infections and cancerous developments. This makes the body more susceptible to certain types of cancers, such as Kaposi sarcoma, and to opportunistic infections that would normally be easily defeated, such as pneumonia (Pneumocystis carinii) and Cryptococcal Meningitis. These infections might result in severe damage or the death of the patients. Therefore, it is not the Human Immunodeficiency Virus that causes death in HIV(+) individuals, but opportunistic infections or cancerous developments that a weakened immune system cannot repel. Hence, the later stages of HIV infection are called Acquired Immunodeficiency Syndrome (AIDS).

In spite of many obstacles, in industrial countries there has been a remarkable improvement in the medical care of HIV/AIDS individuals as a result of testing for HIV on a regular basis, particularly among high risk groups. This facilitates early diagnosis and therefore an early start in medical treatment, which allows HIV(+) individuals to live for decades after diagnosis. However, worldwide, particularly in developing countries, 90% of those carrying HIV have not been tested or do not have access to adequate treatment for the disease. Furthermore, every year a considerable number of HIV(+) individuals in developing countries die without even knowing what HIV is and leave thousands of orphans behind who do not have any idea what took their parents away. The number of people living at critical poverty levels in some of these hardest-hit regions, such as sub- Saharan Africa, has reached over 43 percent in recent years. Women encompass 80 percent of those who are living on less than a dollar a day. For people who live in such abject poverty, neither treatment for an HIV+ /AIDS individual (which normally costs around $25,000 annually) nor routine HIV screening seems realistic. On the other hand, even though testing and medical treatment options are available in developed countries, the economic burden on the health care system is becoming greater with every passing day.

HIV and children

As of 2007, over 2.3 million children are suffering from HIV/AIDS worldwide. A small percentage of these children were exposed to the HIV in medical settings, due to unscreened blood transfusions or reused or insufficiently sterilized equipment. Pediatric HIV outbreaks in Romania in 1989 and in Libya in 1998 are two devastating examples of the consequences of negligent or insufficient precautions taken by medical personnel in hospitals. Currently, health care professionals are required to take strict precautions when cleaning and sterilizing medical equipment, while blood banks are monitored closely to ensure the careful screening of blood. These precautions seem to have led to a significant reduction in the number of HIV infections which are acquired in hospital settings. However, motherto- child transmission still constitutes 90% of pediatric HIV cases. An HIV (+) mother has about a 35% risk of transmitting the virus to her child during her pregnancy, child birth, or nursing. This risk can be reduced by administering AZT (an antiretroviral drug) to the mother during the last trimester of pregnancy, delivering the child by C-section, giving one dose of prophylactic antiretroviral therapy to the baby after birth, and by avoiding breast-feeding the infant. As a result of widespread screening and the use of prophylaxis for mother-to-child transmission, the rapid spread of HIV among the pediatric population in industrial countries is relatively under control.

Sadly, not all nations have benefited uniformly from the recent advances in our knowledge about the prevention of transmission. Mothers and infants in developing countries face a different scenario than those in the “modern world.” In places like sub-Saharan Africa, where the majority of HIV/AIDS cases are due to mother-to-child transmission, the number of new infections is rapidly increasing; it seems that ensuring the abovementioned precautions are in place is extremely difficult due to several limitations. These limitations should be discussed in another paper, however to give a brief idea to the reader, one of these instances can be examined. It is a fact that if an HIV(+) mother avoids breastfeeding her newborn baby the risk of her infecting the child with HIV is dramatically reduced. Although this sounds like a wonderful way to combat HIV infection in infants, it poses many problems to mothers in sub-Saharan Africa. Every year, more than one million babies die in the first 28 days of their life in Sub- Saharan Africa. Most of these deaths are due to malnutrition and infections. In most situations breast-feeding is the only clean source of nutrition a mother can offer her child. It also provides natural immunization against most of the infectious agents to which a newborn can be exposed in the later days of his/her life. Babies who are not breastfed have almost no other alternative source of clean nutrients and stand little chance against infections. An HIV(+) mother in Sub-Saharan Africa has to face this dilemma every single time her baby cries from hunger: either take the risk of infecting your baby with HIV or let your child die of malnutrition or infections which kill approximately 3,000 African children every day.

Another issue concerning children in the hard-hit HIV regions is the loss of one or both parents or primary care-givers at a very early time of their life. So far in Africa, HIV/AIDS related deaths have left 14 million orphans. The United Nations estimates that the number of orphans will reach 25 million by the year 2010. Only in rare cases do these children have access to clean water, food, shelter, and education. Furthermore, the orphans who have been infected with HIV by their parents do not have access to adequate treatment options. The number of orphans is so high and resources are so limited that unfortunately most of these children fall through the cracks of society, succumbing to poverty, abuse and even death. Some of these orphans are relatively lucky and have healthy grandparents to care for them. It is not uncommon to find 75-80 year old grandparents who are already living under the critical poverty level taking care of three or four AIDS orphans, and wondering who will care for their grandchildren when they pass away.

Education

Success against the HIV/AIDS epidemic cannot be accomplished only with scientific and medical means. Preventive education plays a key role in the battle against HIV/ AIDS. The first step in preventive HIV/AIDS education is to inform individuals about the disease and answer their questions, such as, “What causes AIDS?”, “How is HIV/AIDS spread?”, “What are the preventive measures to be taken?” If one is already infected with HIV then one must ask “What are the treatment options?”

Preventive education for risk groups who are not aware of HIV/ AIDS and the consequences of the infection helps to decrease the overall number of new infections, particularly those in developing countries. However, another issue appears as education level increases: according to current studies, the number of people who continue risk-taking behavior is increasing in spite of the knowledge they have about HIV/ AIDS prevention and the consequences of the disease. This suggests overthat effective HIV/AIDS prevention should include not only education about the facts of the illness, but also education that focuses on teaching people to avoid behavior that puts them at high risk. It is also worth noting that the widespread dissemination of information by governmental organizations may not be effective on its own, and that different types of intervention may be necessary by groups with the potential to motivate people on a personal level. In other words, it is important to individually instill a sense of consequence and personal responsibility within those at risk, rather than broadly reminding them of the dangers that they face. As a result of recent thinking along these lines, various institutions, professional groups, and government organizations have realized the need for strong collaborative efforts and have aligned themselves in order to begin taking the steps necessary to effect this type of change.

Working together

Around the globe, government agencies have been initiating and sponsoring several efforts aimedat HIV-prevention. However, the complexity of the HIV epidemic and the involvement of many sociologic and behavioral factors require a shared commitment among government agencies and civil society organizations. For example, the Center for Disease Control (CDC) is the leading federal agency in HIV prevention in the United States. In their strategic plan for HIV prevention in 2005, the CDC admits that the HIV epidemic is not a matter that can be handled by only one agency, group, or organization. Therefore, for success in HIV prevention the CDC recognizes the need for other domestic partners, such as:

~ Other federal agencies;

~ State and local health and education departments;

~ HIV prevention community planning groups;

~ Community-based organizations;

~ Academic institutions;

~ The private sector;

~ Faith-based groups and

~ Foundations and nonprofit groups

(Centers for Disease Control and Prevention HIV Prevention Strategic Plan Through 2005)

In addition to domestic partnership, worldwide cross-cultural and cross-faith collaborations are establishing a strong global response to eradicate HIV/AIDS. People from all over the world should contribute, in whatever capacity and with whatever resources they can, to the solution; their involvement is critical. The World Health Organization, UNICEF, UNESCO, and similar organizations are doing their parts to bring multinational aid to the hardest hit regions. Additionally, many faith-based national and international organizations around the globe have started working in collaboration towards the eradication of HIV/AIDS. Among these faithbased efforts there are recent examples of interfaith partnerships. The Africa HIV/AIDS Faith Initiative, a successful example of this type of collaboration, has been active since 2001 in five African countries: The Ivory Coast, Kenya, Nigeria, Tanzania and Zimbabwe. One of their noticeable accomplishments is promoting interfaith dialogue in these countries where ethnic and religious variations often cause serious clashes. A report from The Global Health Council lays the power of Interfaith partnership before our eyes:

“In Kenya, the Supreme Council of Kenya Muslims, the Anglican Church of Kenya and the Pentecostal Churches of Eastlands, a low socioeconomic community outside Nairobi, have teamed up to reach bishops, pastors, men, women, youth, children and people infected with HIV/AIDS through education and service initiatives. In Tanzania, the national staffs of the Episcopal, Christian and Muslim HIV/AIDS offices meet monthly to exchange ideas and plan together for the effective development, implementation and coordination of HIV education and service interventions.

But it is in Nigeria, with its welldocumented history of religious conflict and recent violence, where the partnering of Christians and Muslims is most remarkable. Observing the establishment of separate offices in each of the four other countries, Nigeria’s religious leadership said “it won’t work here,” and charged The Balm In Gilead to set up the Interfaith HIV/AIDS Coalition of Nigeria. Christian and Muslim clerics going out on the street together can draw curious crowds, and “people will come into the office just to see us working together,” said one reverend.

Nigerian faith institutions involved in this historical decision included the Episcopal Conference of Nigeria, Christian Association of Nigeria, the Christian Health Association of Nigeria and the Supreme Council of Islamic Affairs. This interfaith approach in Nigeria is being seen as a model that can be replicated by other countries. The Kenyan Muslim leaders have already requested that it be presented as a best practice model and replicated in other parts of the continent.” http:// www.globalhealth.org/reports/ text.php3?id=194

Conclusion

We have witnessed many harsh discussions, questions and speculations about HIV/AIDS such as, “How and where did HIV/AIDS start?”, “Whose fault was that?”, “Why don’t people simply stay away from risky behavior and put a stop to it?”, “What are the roles of faith traditions, family values and public wisdom in terms of preventing and fighting against HIV/AIDS?”, “If I am not involved with certain risky behavioral elements am I safe? Are my children safe from HIV?”, “Is contributing to the solution for HIV the same as trying to legitimize the life-style preferences which are the primary cause of the spread of HIV in the first place?”

As a matter of fact, how this epidemic started, whose fault it was, why precautions were not taken on time does not matter that much anymore. What matters is that hundreds of people are dying, thousands of children have been orphaned, and millions of mothers are crying in desperation everyday. We do not have the luxury to sit back in our comfortable seats and be the judge who decides who is right and who is wrong in this drama. We are all human… we are citizens of the earth… we breath the same air, sleep under the same sky. When we cut ourselves, our blood runs red, our tears are salty. Pain is pain… a cry is a cry… desperation is desperation…No matter where we go, what language we speak, or how we live our lives… We are obliged to put the differences to one side and to become a part of the solution…to think about it… to talk about it… to do something about it… or at least with a sore heart cry and pray for our HUMAN sisters and brothers who are suffering from HIV/AIDS… who might not be able to do much for themselves.

So-called ‘new’ viruses most probably derive from existing viruses; in general, viruses of today have ancestors and relatives. However, as viruses show great variety, and many of the viruses of gravest concern mutate rapidly and unpredictably, it is not always possible to trace their ancestry with any great confidence. A ‘new virus may be genuinely new or a major evolutionary variant arising from genetic processes such as mutation or recombination. Their rate of mutation is so high that controlling them, or predicting their behaviour, is well-nigh impossible. High mutation rate means that no RNA (ribonucleic acid) virus population is a single entity, but rather a ‘quasi species’. Introduction of a virus from one species to another and dissemination from a smaller to a larger population are also among the basic mechanisms by which viruses emerge.

The emerging viruses are surfacing from ecologically damaged parts of the earth. When viruses come out of an ecosystem, they tend to spread in waves through the human population. Among the most notorious are: Lassa, Rift Valley, Oropuche, Rocio, Q. Guanarito, VEE, Monkeypox, Dengue, Chikunganya, the Hanta viruses, Machupo, Junin, the rabies like strains Mokola and Duvenhage, LeDantec.

AIDS: Acquired Immunodeficiency Syndrome

Human immunodeficiency virus (HIV) is a more difficult case compared to, for example, influenza, itself a great killer – the influenza pandemic of 1918-9 in China caused some 20 million fatalities. We do not know the origin of HIV, but a probable primate origin is often suggested, and appears highly plausible. HIV-2 (one of the major strains of HIV) may be a mutant that jumped into humans from an African monkey known as the sooty mangabey, perhaps when monkey hunters or trappers touched body tissue. HIV-1 (the other strain) may have jumped into man from chimpanzees – perhaps when hunters butchered chimpanzees.

HIV attacks the type of lymphocytes known as helper T-cells that stimulate the activity of B lymphocytes that produce antibodies. After an HIV infection sets in, helper T-cells begin to decline in number and the person becomes more susceptible to infections.

The AIDS virus mutates rapidly and constantly. It is a hyper-mutant, a shape-shifter, spontaneously altering its character as it moves through individuals. It mutates even in the course of one injection.

The drug AZT has been found to be helpful in prolonging the lives of AIDS patients. Also, it has been shown that administration of Interleukin-2 and AT-538 can prevent viral replication in cells in the early stages of the infection.

The Filoviruses

Marburg and Ebola viruses were recently elevated to family status as the Filoviridae. The name, ‘thread viruses’, is based on their morphology. These viruses made their appearance in the 1960s and 1970s in the form of frightening nosocomial and occupational outbreaks, initially among polio vaccine production workers in contact with Ugandan green monkeys and their kidney tissues, then in independent hospital epidemics of devastating proportions during 1976 in the Sudan and Zaire. Mortality from these infections can range to nearly 90%, that is 90% of infections, not just of clinical illnesses.

The incubation period of a filovirus in a human being, is from 3 to 18 days during which time the number of virus particles climbs steadily in the bloodstream. Then the suffering begins.

Marburg was the first filovirus to be discovered. It erupted in a factory producing vaccines using kidney cells from African green monkeys. Thirty-one people caught the virus. Seven infected persons died in pools of blood in just two weeks. This fatality rate of one in four makes Marburg an extremely lethal agent, yet it is the mildest of the filoviruses. No vaccine is available.

Ebola Sudan

The next indication of the existence of filoviruses came from an extraordinary pair of epidemics in 1976. In the Sudan the initial focus was a cotton factory in Nzara, and several of the earliest recognized cases worked there in a single room. Travel to nearby Maridi introduced the virus into the medical care system, with subsequent latrogenic dissemination that devastated the Maridi hospital. In this outbreak, 150 out of 280 infected people died.

In 1979, it recurred in Nzara, Sudan. The index case had worked in the same room in the cotton factory identified in the earlier epidemic. Twenty-two out of 34 infected patients died. When it first erupted, the medical stuff had used dirty needles which facilitated the spread of infection. Again, no vaccine is available.

Two months after the start of the Sudan emergence in 1976, an even more lethal filovirus emerged. The Ebola Zaire, a new strain was nearly twice as lethal as Ebola Sudan. The fatality rate of Ebola Zaire is 9 out of 10. Staff at a hospital which had been at the epicenter of the epidemic were almost all wiped out: 13 out of 17 of the doctors and nurses died. The disease erupted more or less simultaneously in fifty-five villages near the headwaters of Ebola River.

This epidemic was clearly dependent on the use of unsterilized needles and syringes for its major dissemination between villages, although multiple later generations of cases occurred among family contacts without any defined exposure route.

Ebola is distantly related to measles, mumps and rabies. It is also related to certain pneumonia viruses, to the parainfluenza virus which causes colds in children, and to the respiratory syncytial virus, which can cause fatal pneumonia in a person who has AIDS.

Ebola kills a great deal of tissue while the host is alive. It triggers a creeping, spotty necrosis that spreads through all the internal organs. The liver bulges up and turns yellow, begins to liquefy and then it cracks apart. The kidneys become jammed with blood clots and dead cells, and cease functioning. As the kidneys fail, the blood becomes toxic with urine. No vaccine is available.

Ebola does in ten days what it takes AIDS ten years to accomplish. In principle Ebola-like viruses could spread out all over the world in just one month and a half. Richard Preston, the author of Hot Zone argues that AIDS may be the first step in a natural process of clearance. What is being cleared is human beings: the earth’s immune system, so to speak, has recognized the presence of our species and is starting to kick in and signal its potential to rid itself of an infection by human beings. There can be no excuse for failing to reflect radically on the way we manage our economies, our societies and our lifestyles. We have no absolute right of tenure of this planet, nor does our collective intelligence or our science and technology afford a reliable immunity from vulnerability, whether as individuals or as a species. We do need to be fearful perhaps, though not to panic – so that we redress the balance in favour of humility in our attitudes and activities, so that we become more caring and careful in using our God-given faculties to prevent the worst before it happens.

References

• MADER, S. S. (1992) Human Biology, WCB Group.
• PRESTON, R. (1993) Hot Zone, Random House, New York.
• MORSE, S. 5. (1993) Emerging Viruses, Oxford University Press, New York.
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