Harming our bodies or health is a betrayal against this incredible gift. One of the major ways people harm the body is through smoking cigarettes.

Smoking harms human health in countless ways. It is one of the main causes of many diseases, such as lung and throat cancer, along with cardiovascular and respiratory track diseases, such as chronic bronchitis. According to the latest report from the World Health Organization, smoking remains the fourth of the top ten risks that threaten human health. Approximately 20-30% of adult fatalities are caused by ailments contributed to by smoking. Recent studies have shown the negative effects smoking has on human reproductive functions.

Effects on fallopian tubes

Smoking has a negative impact on female reproductive organs; this impact is determined by how long, and how much, a woman smokes. It may cause infertility by damaging the fallopian tubes that serve as a ground for the egg to be fertilized by sperm. In many studies, the risk of damage to the fallopian tubes was very high – this danger increases if a woman starts smoking a pack a day before the age of 18.

Effects on female hormones

Many toxic substances in cigarette smoke, including nicotine, directly inhibits the activity of the enzyme called aromatase, which plays a major role in the synthesis of the female hormone (estrogen) in the ovaries. Depending on the biological function, estrogen can be found in three different forms: as estrone, estriol and estradiol. Polyaromatic hydrocarbons found in cigarette smoke stimulate the microsomal cytochrome P-450 enzyme system that degrades hormones in the liver and, consequentially, increases conversion of estradiol with high biologic activity into estriol with the lowest activity. Alkaloids, one of the harmful substances found in cigarette smoke, were discovered to prevent production of progesterone in the ovaries. This plays a role in preparing the womb and in continuation of the pregnancy during the first three months. Therefore, smoking leads to progesterone deficiency during the early stages of pregnancy, causing miscarriages.

Effects on the maturation of the egg

The concentrations of the FSH hormone that is involved in the maturation of reproductive cells in the ovaries are especially high in young female smokers. In other words, a resistance develops against the FSH hormone in the ovaries and higher FSH hormone levels are required for the maturation of the egg. Thus, fertilization problems and missed periods can occur because of an absent reproductive cell. During the treatment of such patients with insufficient egg cell maturation, there is a 50% decrease in the success of the implantation (placement of the fertilized egg into the womb) and the continuation of the pregnancy in smokers when compared to nonsmokers. This means smoking significantly reduces ovarian functions, and ovarian stimulation becomes inadequate at earlier ages in women.

The negative effects of smoking on the reproductive system are also observed during the implementation of reproduction methods such as in vitro fertilization and assisted fertility technologies. The presence of high androgenic hormone levels (pre-metabolites of gender related hormones: androstenedione, DHEAS and testosterone/SHBG) in female smokers has been found to decrease the possibility of pregnancy during in vitro fertilization efforts.

Effects during pregnancy

There are many harmful consequences of smoking during pregnancy, especially for older women who are pregnant. Some of these consequences are premature birth, miscarriage, retardation of development, inadequate baby weight, perinatal mortality, ectopic pregnancy, placental praevia, and placental abruption. Placental praevia is the abnormal placement of placenta in the womb. In this case, depending on the excessive bleeding that occurs after the eighth month of gestation, the lives of the mother and fetus become imperiled, and fetal development is hindered. Placental abruption occurs depending on the premature separation of placenta from the womb, causing excessive bleeding that can also endanger the lives of the mother and baby.

In pregnant smokers, the postnatal ratio of infant mortality and disability increases as a consequence of deficiencies involving lung function and nerve development. These effects are directly proportional to how much a woman smokes. There are also negative impacts when a pregnant woman is exposed to second hand smoke by a spouse or close friend. Harmful metabolites of nicotine reach the baby via the placenta. Furthermore, nicotine is degraded slowly in the liver of a pregnant woman. Inadequate baby weight is related to smoking dosage and time.

Due to smoking in the early stages of pregnancy, the hormone levels of estriol, estradiol, progesterone and hCG, hPL which is secreted from the placenta, have been found to decrease. This reduction, which is observed in parallel with the amount of smoking, can result in miscarriages.

Toxic polyaromatic hydrocarbons have been found to accumulate at elevated ratios in the wombs of women who were exposed to cigarette smoke for a long time. During pregnancy, this situation leads to the deterioration of sertoli cells located in the reproductive glands of male fetuses. These glands assist in sperm production during adulthood, and damage to them can therefore cause a reduction in sperm generation.

An insufficient placental development occurs because of the negative effects of nicotine, cadmiums, and polyaromatic hydrocarbons damage the reproduction of trophoblast cells that make up the placenta. This situation explains the increasing miscarriage ratios among female smokers.

The free T4/TSH ratio in the serum of the umbilical cord, which connects the fetus to the placenta, increases in the babies of smokers compared to those of nonsmokers. This means that in babies of smokers, the thyroid glands may become overactive during birth. Depending on a mother’s smoking habits, this hyperactivity of the fetal thyroid increases the metabolic speed and the amount of consumed oxygen in the body, thus leading to the inadequate development of fetus.

Menopause occurs two-to-four years earlier due in women who smoke, as compared to non-smokers. This is due to the aging of the eggs. The risk of entering menopause before the age of 45 in women who quit smoking at least ten years prior is 87% less than smokers who don’t quit. Therefore, the earlier a woman stops smoking, the lower the risk of early menopause.

Effects of smoking on men

In research studies, it has been discovered that smoking has many harmful effects on testicular development and functions. These effects can be summarized as follows:

• Reduction of semen volume and quality, increase in its adhesiveness, delay in its becoming liquid, and resulting deformation of the sperm.

• Reduction in the number and mobility of sperm cells.

• Delayed sperm nucleus maturation, deteriorated DNA integrity.

• Decrease in the production of testosterone from Leyding cells.

• Decrease in the egg fertilization capacity of the sperm.

As a consequence of these negative effects, male infertility can occur. As the amount of daily cigarette consumption increases, the number, strength, and types of anomalies also increase. In a study conducted in 2010, smoking has been showed to decrease zinc levels in the seminal plasma. As a result of this decrease, oxidative agents populate and DNA breaks take place, thus causing a disruption of sperm functions and infertility. Zinc deficiency at the same time leads to the destruction of seminiferous tubule cells where sperm cells are produced. Paternal smoking generates negative results during the application of assisted fertility methods (such as in vitro fertilization). The damage in the sperm DNA of the father can disrupt the embryo development. The risk of anomalies, cancer, and genetic diseases increases for the fetus.

Cigarette smoking clearly occupies a position as one of the worst enemies of mankind because of its destructive effects on the body. In this case, it does not make any sense to try finding excuses for smoking, for it is harmful to the body that has been loaned to us as a gift and a temporary property.

Cihanoglu is a professor of medicine in KATU, Trabzon, Turkey.

We are now approaching the end of the series of organs that told you about themselves. They have been pointing out the seal of God on them, and celebrating themselves as they manifest the beauties and the delicacies of God’s art. Thus, they have not only expanded your knowledge, but also guided people to the truth of God’s Oneness, stressing that natural and biological causes alone can never be an explanation for their splendid creation.

Each of your organs told you about its perfect structure and how it functioned within your body system. Let us think that each organ is a musical instrument. No matter how splendid and artful a musical instrument is, its true value is understood only among other orchestra instruments as they perform a wonderful concert. Your body is like that orchestra, where hundreds of instruments play together. In addition to the perfect structure of each organ, more importantly all the organs have to work together perfectly as a team. The success of an orchestra depends on how the instruments play in harmony with each other. The conductor of an orchestra is the person who ensures that harmony. The orchestra members carefully watch the conductor and play according to his arm movements, sometimes louder or softer, sometimes pausing or breaking into a very loud introduction. That is how a perfect concert can be performed.

In order to achieve such harmony, the organs in your body need a system that works just like a good orchestra conductor. This “regulating system,” which has to maintain the perfect harmony and order of the ongoing activities in your body, has two sub-units: One is the brain and the nervous system, and the other is me; your endocrine system (hormonal system). Since I work as a system that consists of many organs, from now on I will refer to myself as “us.” Each of us adjusts itself to the whole system by carefully watching the movements and works of the other organs. At our head are the brain and nervous system, which act as the general control center. However, it cannot carry out the regulating and controlling task alone; it needs our help.

The most basic principle that your body has to follow in order to maintain its health is keeping the inner medium stable in a dynamic balance while responding to varying environmental conditions properly. This is also known as homeostasis. For the inner medium to be kept stable, it is first of all important to be aware of the changes that are happening in the outer world, which is initially done by your sense organs. The signals related to the changes in the outer world are sent to your brain and nervous system through the sense organs. Afterwards, the signals are evaluated, and then they are sent to the related organ so that the proper reaction is produced and the inner balance can be regained. While all the activities regarding growth and reproduction are carried out, the inner medium should be kept stable at the same time (homeostasis). In order for all these activities to be performed continuously, you need inner secretion glands, which are small, but highly important.

The most important of all your organs that constitute the endocrine system is called the Pituitary (hypophysis) gland, which is recognized as the commander of all these organs and situated in your brain. The other secretion glands included in my system are the thyroid, parathyroid, suprarenal (adrenal) gland, epiphysis, pancreas, testicles, and ovarium. Now, these small but very important organs of mine will respectively talk about themselves and demonstrate the perfect program and the sensitive balance within which they work. You are the one who will draw the necessary lessons from this.

In all tissues, there are specific recipient molecule groups that respond to a particular hormone. Each hormone is programmed to stimulate its target cells, which contain those special recipient molecule groups that start doing their specific work. The principal functions of my endocrine system are: to enable growing; to regulate the necessary reproduction process in an ordered manner; and to carry out the physiological processes in the body in a relatively stable medium. I guess your amazement, admiration, love, and apprehension will increase when you hear about my secretion glands. Now, here comes the hypophysis.

My name is Hypophysis (the Pituary Gland)!

I am appointed as the commander of all your glands. Therefore, I am situated in a very firm place at the lower brain. I am an organ that is as small as a bean and that weighs only a few grams, but I have got so many talents. I have two parts. The first is my frontal lobe (adenohypophysis) which secretes most of the hormones. Our Creator has given key roles to the hormones of my frontal lobe to direct secretion activities of other endocrine glands. For example, thyrotropin hormone is arranged in such a way that it affects the thyroid gland and stimulates it for secretion. The unbalance in my thyrotrophic secretion affects the function of Thyroid gland negatively. If it is secreted too much, hyperthyroid; if it is secreted too little, hypothyroid illnesses emerge. In both cases, some problems occur during metabolism. Adrenocorticotropic hormone is created to arrange the activities at the adrenal cortex. Follicular stimulating hormone has two very important roles. The first one is regulating the secretion of estrogen, which is one of the female hormones. The second one is maintaining the physiological activities in the maturation of sperm cells in males, as well as the egg cells in females, for the continuation of human generation. The Luteinizing hormone together with the Estrogen stimulates the secretion of other sexual hormones (progesterone and testosterone).

When you were born, you were 20 inches tall. Now you are almost 6 ft tall. Both your height and your hands and feet grew. Meanwhile, your head and body got bigger proportionally. Another important secretion of yours that controls your growth appropriate to your age is somatotropin hormone. If, for some reason, my working balance got deteriorated, and this hormone secreted less, you would be like a dwarf, or some of your parts would be unbalanced with your body and abnormally short. If this hormone were secreted too much, then you would get into gigantism due to abnormally large growth. Together with gigantism illness, several problems occur; i.e., heart and blood pressure problems, muscle weaknesses, and problems regarding immunity and general metabolism.

Other hormones that are secreted from my frontal lobe are prolactin hormones, which help milk glands develop in expecting mothers, and melanocyte stimulating hormone, which stimulates the pigment cells that give color to your skin. However, these two hormones have no relation with the other hormonal glands.

The lipoprotein molecule of my melanocyte stimulating hormone helps the morphine substances, known as encephalin and endorphin, to be synthesized. You can call these two substances naturally inherent drugs. These secreted substances help you to bear several physical pains. The secretion of my hormones has direct relation with your nervous system and psychological well-being.

Although formed in the hypothalamus part of the brain, one of the hormones that is secreted after being stored in my back lobe (Neurohipofiza) is oxytocin, and the other one an antidiuretic hormone called vasopressin. Oxytocin makes the smooth muscles work. In particular, it stimulates the contractions at uterus during labor and delivery, and it also stimulates the secretions of milk canals by making them contract. Vasopressin enables blood vessels to shrink, causes the blood pressure to increase, and also reduces the production of urine by increasing the transition of water to blood through the kidneys. Hence, it prevents dehydration in hot and dry weather. In the deficiency of the secretion of this hormone, an illness called diabetes insipidus will occur and water metabolism will be deteriorated. I have more amazing features to tell, but I should not be selfish. I think it is time for Thyroid to speak.

My name is Thyroid!

I am placed in your neck, right at the two sides of the trachea (air tube) and below the larynx (voice box). I consist of two pieces that are attached to each other with a thin tissue. Inside me, there are many little saccules called Follicules which are densely surrounded by a capillary network. Following their innate program my cells produce three important hormones in the cavities of those saccules. The two of them are thyroxine and triiodothyronine, which contain iodine atoms and the other one is calcitonin. My hormones have highly important impact in your body. Our Lord God has appointed me, the hormones secreted by a very small piece of flesh, with regulating the oxygen use of all of your cells, and thus the speed of your metabolism which all affect your body’s overall performance. In addition to that, I also adjust your cholesterol level by lowering it in your blood. My iodine-containing hormones are vital for children’s growth. In the case of their deficiency, conditions like growth failure, dwarfism and mental disorders appear. If there is not enough iodine in the earth or water, it becomes more difficult for me to produce hormone and I start to work harder, which causes me to enlarge. This is a disease called goiter. When I secrete excessive hormone, your eyeballs become bulged, a disease called exophtalmic goiter or Basedow syndrome.

My iodine hormones and the stimulating Thyrotropin hormones secreted by the Hypophysis work together; they watch and control each other. If I get lazy and slow down secretion, the Hypophysis immediately warns me. If I secrete too much, this time Hypophysis stops warning me and waits for me to “calm down.”

Do you see what a wonderful system I am? Not only between us, but also all other systems have the same feedback organization between themselves and the Hypophysis. The Hypophysis is an organ as big as a chick pea, and we are only a small piece of flesh. Peter, look at the great jobs we are doing! Can coincidence play any role in this, do you think?

Lastly, I will tell a little about Calcitonin, a hormone which works to adjust the calcium level in the blood serum. That is not an easy job at all. This hormone is vital in the healthy growth of your bones; otherwise your bones will empty, get weak and they might even break for no reason at all.

My name is Parathyroid!

As my name suggests (“para” is a prefix signifying alongside of, beside), I am located just behind the Thyroid, consisting of four small parts. I have so many important functions beyond what is commonly known. My foremost duty is to delicately adjust the amount of calcium between your skeletal bones and your blood. Moreover, I am also assigned with controlling the phosphate and magnesium metabolism. In order to do that, I produce a hormone called parathormone. Of course, I have no idea about the chemical composition of this hormone; but I am just doing my job by producing it and working as I am programmed. When the level of phosphate in the urine and the level of calcium in the blood are measured, you can understand whether I am working well or not. The decrease of calcium in your blood leads to the stimulation of your nerves, thereby causing muscle spasms or titanic contractions that occur along with dotage. The healthy function of your heart and muscles highly depends on this calcium. Who knows, Peter, what other functions of me you human beings will discover in the future!

My name is Adrenal gland!

I consist of two little parts located on top of the kidneys, one on each side. Do not underestimate me by just looking at my size! You will be amazed to learn what crucial functions I perform. Each of my parts has an inner (medulla) and an outer (cortex) section. Those two sections differ quite markedly from each other in their structure, functions and in the origin of the embryonic layer where they form. But despite those differences, our God Almighty has put them one within the other. The two important hormones that my inner section secretes are Adrenaline and Noradrenaline. My adrenaline secretion speeds up the conversion of glycogen (in your liver) into glucose, and thus the sugar level increases in your blood depending upon your energy needs. This increases the power and the speed of your heart contractions and constricts the diameter of the blood vessels, thereby causing the blood pressure to increase. I assist in dilation of the narrow bronchioles of your lungs so that you can get more oxygen. When you become nervous, quarrel with somebody, face a danger or experience any stressful moment, I cause all those activities to happen by secreting more hormones expeditiously. That is how I help in protecting your body. All in all, 80% of my secretion is adrenalin, whereas the 20% is noradrenalin. Noradrenaline has less impact on your heart and metabolism.

My cortex (outer section), where steroid types of hormones are produced, secretes aldesterone, cortisol, and some androgens (a male hormone). Aldestrone regulates the water and salt levels (especially sodium and potassium metabolism) of your body. Cortisol meets your glucose needs if you are starving by breaking down the proteins into amino acids; it is also responsible for preventing the infections and allergies. Although the testicles (male reproductive glands) are the main organs that produce the male hormones, I also supply them. My androgens help in the development of male characteristics such as voice changes, beard and moustache growth and hair growth. When women get older, the androgens that I secrete causes the voice to deepen and hair to grow on their bodies.

My name is Epiphysis (Pineal gland)!

I am a small gland that is situated at the roof of the dieencephalon (“interbrain”). As it is most commonly known, I secrete the melatonin hormone. This hormone helps the melanin (the black or brownish pigment that gives your skin its color) to aggregate or dissolve in the special skin cells called melanophore. Thus, it senses the intensity of the light that changes according to the seasons and day length, and adjusts your skin color by lightening or darkening it. Moreover, I work as your biological clock, regulating your sleep-wake cycle. It is also thought that I arrange the different working periods of your organs.

Our Name is Testicles!

We are male reproductive glands. Our God Almighty has created us for the continuation of human generation. Each of us is oval-shaped and located in a pouch that weighs 25 grams and facing to each other. Each of us is protected by a case of skin and muscle. This case extends into our internal part where it is divided into 200-400 lobules. Each lobule consists of fine coiled tubes. The reproductive cells and the sperm cells which contain a group of your genetic program are produced in those tubes.

When you reach puberty, upon responding to the stimuli that comes from the hypophysis, we start to produce sperm, as well as Testosterone, a type of androgen (male) hormone. Testosterone is necessary for your male appearance; it helps in the developing the characteristics that distinguish you from females in terms of appearance.

A special cell division called meiosis is needed for sperm production. Along the layer that make up the walls of the coiled tubes lie the cells that are called Spermatogonium. Each of these contain 46 chromosomes (23 maternal and 23 paternal). As a result of serial divisions and crossover of those cells, new cells are created with new characteristics. From one Spermatogonium, four sperms are formed and each of them has 23 chromosomes.

Each sperm differs from one another, and each of them contains a mosaic composed of the different characteristics you possess. Among the millions of sperms that are produced, not one of them is identical to another. The reason is the interchange of sections between pairing homologous chromosomes (that you take from both your mother and your father) during the process of meiosis. For example, in one sperm, your nose traits that come from your father might come together with the ear traits that come from your mother. In another sperm, for example, the fingers traits that are inherited from your father might come together with the eye traits that are inherited from your mother. When so many different traits can be mixed in so many different ways, you can imagine the great potential of variety for human beings.

We are private organs that some people see as “obscene” to talk about and which generates “dirty” sperm-containing fluid. However, as you have seen, we are given to you as a gift from God, wrapped with so many beautiful meanings, one of which is the important task of continuing human generations.

My name is Ovarium!

Dear Peter! My duty is particularly relevant to women; I am the female reproductive organ. Therefore, I should begin by saying something like ‘I am Jenny’s…’ this time. Just as the Testicles are the male reproductive system, the ovaries are the woman’s organ. It cooperates with the male productive system in order for human generation to continue. We, the two ovaries, are located in the lateral wall of Jenny’s pelvis, one on the left and one on the right, and we measure approximately 1x 0.60 x 0.60 inches and weigh between 4 and 8 grams. Even before Jenny was born, we contained an amazing 150–500 thousand immature egg cells inside us.

During childhood, the follicles which contain the eggs diminish continuously, and by the time a young girl reaches puberty, only 35,000 of these follicles remain in each of her ovaries. Throughout the woman’s reproduction lifespan, usually between the ages of 13–50 years, a mere 300–500 of these follicles actually transform into mature eggs. You will certainly realize that you have reached puberty when I begin to produce the estrogen and progesterone hormones. As the estrogen I produce stimulates the development of the female’s sexual characteristics, progesterone prepares the wall of the uterus, making it more receptive to the implantation of a fertilized egg. If the egg I produce is not fertilized by sperm, every month (in approx every 28 days), it will degenerate and then be discharged from the body together with the lining of the uterus during menstruation. Then another one of my eggs matures, and patiently begins to await sperm.

The principle event of chromosomal change in my eggs and their diminishment in numbers is the same in the development of sperms. The only difference being that every spermatogonium produces four sperms, whereas only one mature follicle is produced from the mother cell (Oogonium) that produces my eggs. The remaining three are degenerated. You would have thousands of eggs awaiting fertilization if this was not the case. However, due to the fact that your bodies are not capable of harboring and protecting so many eggs, our Creator provided you with the mechanism of reducing the number of these eggs, and therefore relieved you of any difficulties.

I must take this opportunity mention another two of my organs, one of which is the pancreas, who described itself previously (see The Fountain # 67). As you may recall, the pancreas is a compound gland. The pancreas previously described how it produces digestive enzymes, and also how it produces insulin and glucagon to deal with the metabolism of carbohydrates. As this is a very complex organ, we allocated the pancreas the opportunity to describe itself and explain its functions in a previous edition of the magazine. For more information you may refer to the issue listed above.

An organ which is a part of your immune system, and also considered part of the endocrine system, but an organ you are probably unfamiliar with, is the Thymus gland. If the immune and lymph systems feel the need to describe themselves to you in the future, the Thymus gland will inform you that it resides at the same level as your heart, behind your breastbone (sternum). Then it will go on to define its specific duties. But for the moment, the only thing I am going to inform you of is the most important duty of the Thymus gland.

The Thymus gland produces soldiers called T lymphocytes (T cells) and special antibodies which fight the invasion of diseases, illnesses, and also attack cancer cells and any foreign antigens. The Thymus gland is recognized as a part of the endocrine system because it produces hormones and antibodies. The special lymphocytes and antibodies that are produced in such a complex process by other organs of the immune system are transformed into T cells as they pass the Thymus gland. Then, gaining new characteristics, they secrete specific hormones which in turn stimulate the development and differentiation of T lymphocytes.

Whatever the system may be, the Thymus gland, to the contrary of other organs, is at its largest and most active during the embryonic and neonatal periods. During adolescence, the Thymus gland begins to shrivel and shrink, and continue to shrink gradually into old age. The reason why the Thymus gland is large during the early stages of life is because it must constantly generate new antibodies to enable the body to fight against new germs and diseases, which the body encounters every day.

I may have extended the topic slightly this time because every organ of my endocrine system described themselves individually, and then we got onto the subject of Jenny’s special case, as wel as the different aspects of Peter’s case. All the organs I mentioned today are small, but as you may have noticed, these small organs behold great mystery and wisdom. In addition to this, all of these organs’ individual duties are connected, in particular the Pituitary gland (Hypophysis), and have been arranged and regulated in such a way that they control one another. Can such a magnificent hormone system and bodily activity working in such harmony be explained as a mere coincidence?

Irfan Yilmaz is a professor of biology at Dokuz Eylul University, Izmir, Turkey.

Original Article: Wang, M. et al., PNAS (published online before print on March 1, 2010).

Periodic injections of insulin to manage blood sugar levels is critical for the treatment of diabetes patients. It requires continuous monitoring of glucose levels in the blood and multiple injections of insulin in order to mimic the natural balance of sugar-insulin levels in the human body. Yet, it is often difficult to maintain this extremely sensitive hormone balance without major side effects. These complications include blindness, leg ulcers and amputations, heart vessels problems, renal insufficiency, stroke, and nerve damage in the legs and arms. Moreover, the long-term use of insulin causes the increase of body fat and bad cholesterol. A new research study on non-obese diabetic mice shows that adding leptin- a hormone responsible for appetite control- to the insulin therapy results in better control of blood sugar levels and decreases the bad cholesterol and body fat of Type 1 diabetic mice. This is promising, as it could reduce heart and circulatory complications of Type 1 diabetes. However, the leptin therapy may not have an effect on type 2 diabetes, adult type, because in this type patients already have high levels of leptin. However, it has to be shown that leptin therapy is safe and effective on humans as well. There is a long way to go before we can use leptin in practical areas.

2- Re-teaching speech with music

Original Source: Schlaug G, Annual Meeting of the American Association for the Advancement of Science (AAAS), San Diego (2010).

Nearly 800,000 people in the U.S. are faced with strokes each year, and a quarter of those are affected by aphasia, a deficit in language. Using a new melodic intonation therapy, therapists treat patients by teaching them how to sing words and phrases consistent with the underlying melody of speech. As a result, the patients continue to speak in a more “sing-songy” way than a person with normal speech patterns, according to Dr. Schlaug, professor of neurology at Harvard Medical School. After 15 weeks, 1.5 hour-long daily sessions with a therapist, the patients gradually learn to piece the sung words together into organized speech. There are two separate brain networks associated with vocal output, with the one in the left hemisphere being engaged with speech and the other one in the right hemisphere strongly responding to music and melody. For the stroke patients that had damage to the left hemisphere, this therapy may help to train similar areas on the right hemisphere, helping them to initiate a speech region in the right hemisphere. Singing facilitates necessary engagement to the right hemisphere. Images of patients’ brains before and after the therapy reveal striking structural and functional changes in the right hemisphere. This study also reminds us of the brilliance of musical therapies employed in early hospitals in the Islamic world.

3- Renewable Jet-Fuels

Original Article: Bond, J.Q. et al., Science 327, 1110 (2010).

The global need for sustainable energy resources is ever increasing and the use of renewable fuels offer promising solutions. Among others, biofuels are especially important due to the presence of direct conversion routes from plant-based waste materials to conventional liquid fuels. However, high synthesis costs and complex processing steps are major hurdles to overcome before putting biofuels forward as economically viable alternatives to fossil fuels. Researchers are therefore trying to come up with more efficient methods -and one group, from the University of Wisconsin appears to have done so. Unlike commonly utilized routes involving microorganisms, they use a novel and environmentally-friendly chemical process which is easier to control and maintain. By using an inexpensive catalyst, they convert the majority of the wasted biomass to gaseous butene and carbon dioxide, with a water-based solution of gamma valerolactone as the intermediate chemical. The butene gas is then easily transformed to high-energy transportation fuels such as gasoline and jet fuel. As an added advantage, the stream of carbon dioxide can be efficiently captured, preventing the atmospheric release of this major greenhouse gas. Under optimized conditions, the system can operate uninterrupted for 90 hours with an overall efficiency of over 75%. Successful work like this will help make biofuels cheaper for mass production, pending the meticulous analysis of its economics.

4- Salt controversy: How much is too much?

Original Article: Bibbins-Domingo, K. et al., NEJM 362, 590 (2010).

Modern humans suffer from high rates of obesity (for instance, 64% of Americans are classified as either overweight or obese) and cardiovascular diseases, with the latter being the no.1 cause of all deaths. A recent study conducted by researchers at the University of California at San Francisco suggests that reducing dietary salt by half a teaspoon a day (~ 3g) would lower the annual number of new coronary heart disease, stroke and myocardial infarction cases. Strikingly, such a modest decrease is expected to decrease deaths from any cause by 44,000 to 92,000. According to the National Salt Reduction Initiative, Americans eat at least twice as much salt as they need where 80 percent of the salt in the American diet comes from processed or restaurant-prepared foods. However, eating too much salt is not a problem for people with healthy kidneys since kidneys are designed to flush out unneeded salt. However, when people have a high salt diet, then their kidneys are over-worked. Taking into account that modest salt reduction in one’s diet won’t likely cause harm and taste buds will likely adapt to this minor change effortlessly, it seems wise to refrain from using too much salt. This would trigger bigger health benefits ranging from not overworking the kidneys to reducing the risk of deadly diseases.

5- Why don’t we get thirsty during sleep?

Original Article: Trudel, E. & Bourque, C.W., Nature Neuroscience (published online before print on February 28, 2010).

In mammals, the “internal-standard-time” is kept by a particular subset of brain cells known as “clock-neurons” which display high activity during the day and low activity during the night. A group of scientists recently reported that the clock-neurons also function as a dimmer for water regulation, allowing bodily water content to be controlled by the body. A specialized group of cells, called osmo-sensory-neurons, detect and regulate water levels in the body, through balancing the water intake via thirst and loss via urine production. When water levels are low, the sensory-neurons communicate with some hormone-releasing cells which instruct the body to store water by ceasing urine production. By using isolated brain slices from rats, the researchers showed that the clock-neurons – when active – interfere with the communication between sensory-neurons and hormone-releasing-cells to suppress the water-storage-hormone release. In contrast, when the clock-cells are inactive (i.e., ‘sleep period’) the communication is restored, resulting in an increase of hormone levels to enable water-storage. Such regulation is the reason why we are not much disturbed during sleep by neither frequent trips to the bathroom, nor excessive thirst (that would both impair the sleep quality), and reminds us the verse from the Holy Qur’an: “..and He has made the night for rest…” (Chapter Al-Anaam, 96).

6- A passage to vegetative state through fMRI

Original Article: Monti MM et al., NEJM 362, 579 (2010).

Consciousness in medicine is defined as the patient’s alertness and responsiveness to the outside world. If a patient does not respond to external stimuli, his/her medical state is considered a “vegetative state”. Researchers from Cambridge, England performed functional magnetic resonance imaging (fMRI) experiments on 54 patients who had been previously classified as either “vegetative” or “minimally conscious”. Interestingly, 5 of 54 patients exhibited distinct neuronal activities in the corresponding regions of their brains, when they are given imaginary motor and spatial tasks. For the motor task, patients are asked to imagine playing a tennis game. For the spatial task, patients are asked to imagine navigating through a familiar location. A 22 year-old man who had been in coma for five months was further evaluated by being subjected to a simple set of yes-or-no questions such as “Do you have any brothers?” and was instructed to answer these questions using one type of mental imagery, that is a motor imagery for “Yes” and a spatial imagery for “No”. He answered 5 out of 6 questions correctly. This is the first evidence that through fMRI approach one can reach the residual cognitive activity in vegetative patients and establish functional communication, raising question marks about our current handling of these so-called vegetative patients.

Hypertension is one of the most widespread dangerous diseases of this century affecting the young as well as the elderly. It can lead to other, more dangerous conditions, coronary and brain diseases among them.

The two main causes of hypertension are stress and being overweight conditions associated with the life-style of the materially wealthy, industrialized nations. (We may note in passing that Islam forbids excessive consumption whether in or in goods, and it requires the believers to halt their daily routines at least five times a day for prayer – and prayer, standing or sitting in the presence of the All-Mighty, gives due proportion to all human affairs, enabling the worshipper to obtain or recover calm of body and mind.) .

Doctors nowadays recommend patients with hypertension to eat less salty foods, to avoid becoming overweight and to keep fit by doing light but regular, frequent exercise. But; before that, doctors ask them to give up drinking and smoking if they indulge in these habits. (Again, we note in passing that the life-style being recommended makes up a prescription as familiar to Muslims as the Qur’an and Sunna.)

Hypertension adversely affects blood pressure; to keep the pressure at normal level, the blood vessels constrict. That constriction may, in turn, cause damage when it passes beyond certain limits. It can overload the heart, soon leading to coronary vascu1ai diseases. On the other hand, excessive blood pressure not reduced by constriction of the blood vessels may damage the vessels and, subsequently, lead on to brain and liver diseases.

The first measurement of human blood pressure was taken in 1834. An apparatus like the type most commonly used today was introduced in 1896, with some operative improvements in 1906 (Weinstein, 1976). We meet the first accurate descriptions of what we now know as ‘essential hypertension’ in a series of clinical papers by F. A. Mohammed between 1874 and 1881 (Page, 1988).

It comes as a surprise to learn that hypertension was first recognized as a serious health problem only in the late 1930s. During the 1920s, the textbooks used in leading medical schools throughout the world made no mention of hypertension as a problem, let alone as a disease. The association of hypertension with stroke, heart failure and renal failure was still nebulous (Page, 1988).

A research group under Irvine Page were trying to demonstrate the connection between hypertension and coronary heart diseases and to convince the authorities of the time about the importance of treatment for hypertension. When this group announced, with another group of researchers, that they had found a hormone which is very important in the regulation of blood pressure, there was little or no interest. Page’s group had named the hormone ‘angiotonin’, while the others had named it ‘hypertension’. The two groups got together and agreed on the name ‘angiotensin’ for the hormone. Page suggested that angiotensin was one of the important factors in blood pressure regulation. The active form of this hormone, Axigiotensin-2, caused the blood vessels to constrict so that the blood pressure could be kept at a certain level. Therefore, hypertension could be relieved by preventing the synthesis of this hormone.

As the years passed, the number of researchers and organizations working in the field (as well as funding) increased dramatically. Drugs like ‘captopril’ and ‘enalapril’ were developed, which would block the production of angiotensin and hence give some temporary relief to sufferers of hypertension. Today, hypertension is a major medical research area usually carried on under the broad category of brain and cardiovascular research.

When Dr Ibrahim Benter, A Muslim chemist and doctor, came to the Cleveland Clinic to work as a research scientist. Dr Ferrario was the head of the brain and cardiovascular research department. Having worked with Irvine Page at the Cleveland Clinic earlier, Dr Ferrario had been interested in angiotensin for several years.

He had previously shown that Angiotensin 1-7 a trimmed version of the hormone Angiotensin-2, was synthesized in various sites in the human body. However, he was somehow unable to show its effects via live-animal experiments. Despite his reputation, his articles on this particular subject were rejected everywhere. One reason for this was the consensus of the research community that submolecules of Angiotensin-2 were ineffective. After several years of fruitless research, Dr Ferrario had begun to lose hope.

The story of Angiotensin 1-7 attracted Dr Benter’s interest. He had a simple and sound principle: ‘The All-Mighty would never create something that is useless.’ Since angiotensin was synthesized in various places in the body, it should have a definite function. He decided to do some experiments in his own lime during his stay in the Cleveland Clinic. When he mentioned his idea to colleagues some of them smiled and told him not to waste his time. Briefly, they were saying ‘We spent several years and got nothing out of this research; you should not make the same mistake.’ Everybody seemed to have convinced themselves that Angiotensin 1-7 was useless.

However, Dr Benter was determined. He began his experiments using his own set-up and techniques in the expectation of turning up something missed or neglected in previously used methods. Dr Ferrario, having noticed Dr Benter’s efforts, visited him from time to time to see if anything new had turned up. When several trials yielded no positive findings, Dr Ferrario gave up all hope. Not so Dr Benter. I us determination was grounded on his belief that all scientific research is like a prayer to the All-Mighty, and that discoveries are part of the results of the acceptance of these prayers. Since God is the One who makes all progress possible our duty is to work with faith in a systematic way.

Shortly afterwards, he received the reward for his patience, faith and determination. Angiotensin 1-7 was not useless at all. It was a hormone with a function of profound importance – it was just that certain mechanisms in the body hid its effects from being easily observed. When he determined those mechanisms and disabled them, he clearly observed the effects of Angiotensin 1-7. The results were very significant. When acting alone, Angiotensin 1-7 lowered the blood pressure considerably; it could therefore be used as the basis For a new medicine against hypertension, one with fewer side- effects (sec Renter. 1992).

On learning about Ibrahim Benter’s findings, Dr Ferrario gathered all the researchers in the department in Ibrahim’s lab: he wanted them all to see the results. As his colleagues watched the gauges with awe and surprise. Ibrahim was silently thanking his Lord for the success He had bestowed.

They quickly prepared an article, sent grant proposals to relevant institutions and requested support for further research. The response was positive. They were given a research fund of approximately 1.5 million dollars to continue their study. When the official from the funding institution visited them, he said privately to Ibrahim Benter ‘without your findings, this grant would not be possible’.

Dr Ibrahim Benter is probably even now continuing his research on Angiotensin 1-7. When interviewed on the subject, he explicitly asked the following comment to be made public:

This achievement, for which many other more experienced and skilled researchers worked fruitlessly was made possible only by God’s help.’

The story we have just told, is perhaps one example among countless others which demonstrate the role of faith and determination in achievement. If it was successful in bringing an important fact to our attention, or refreshing our confidence in it, then our telling the story has served its purpose. 

REFERENCES

• BENTER IBRAHIM (I 993) ‘Cardiovascular Actions of Angiotensin 1-7’, Peptides, Vol.14. pp.679-89
• PAGE, Revise n. (1988) Hypertension Research: a memoir. Pergamon Press. NewYork.
• WEINSTEIN, MILTON C. (1976) Hypertension: A Policy Perspective. Harvard University Press. Cambridge MA.

Animals produce hormones in special endocrine glands which store the hormones or release them into the circulatory system. According to their chemical structure, animal hormones are classified as peptidal or steroidal and are easily sub-grouped according to their effects. In plants, however, the production of hormones occurs as a result of many cells co-operating. Since plants do not have any circulatory system the hormones are present only in certain parts of their structure and may travel short distances. Plant hormones can be classified chemically as purine based (cytolunins), amino acid based (auxins) or tespenoid based (dolmins, giberellins). The well-known compound, ethylene, is one of the major plant growth hormones doing its work through the air spaces between plant tissue and cells.

Although animals and plants are in most ways totally different types of living things, they produce or synthesize the same chemical compounds, with hormones often the common link. Now we know that plants have some animal and human hormones, and animals have same plant hormones. The hypothesis of hormonal interaction between plants and animals is supported by results from entomological studies:

‘There are hormonal interactions between plants and animals which are possible at many levels and depend on the ability of physiologically active chemicals to interact between the different types of living organism. In some cases the animal is the dominant partner in the interaction; for example, when leaf-cutting ants add auxin hormone to the fungal colonies on which they feed in order to maintain their growth and vitality. More frequently, the plant is dominant, exerting its effect by synthesizing animal hormones and pheromones and thus influencing the life and survival of its animal predators.’

Early reports of the presence of female sex hormones in seeds of the date-palm and pomegranate were received with scepticism and at times rejected. The reports were accused of relying on findings based on the use of crude research apparatus. However, the use of better equipment and more accurate analytical methods has clearly corroborated the early findings. The one issue still not resolved is the precise amount of animal sex hormone in plants.

Reports of unidentified oestrogenic materials in many plant tissues, based on their ability to upset the normal menstrual cycle in woman, cows or ewes, suggest that oestrogens may be much more widespread in plants than has ever been formally recognized. During the Second World War for example, women in Holland attributed menstrual upsets and ovulation failures to the eating of tulip bulbs (forced on them by food shortages). Among the more usual sort of foodstuffs that have affected oestrus in women and cows are garlic, oats, barley, rye grass, coffee, parsley, potato tubers and sunflower. It is possible that some or all of these plant materials do not themselves have the hormones but have, instead, compounds which mimic their effect. At the moment it is not known why plants produce these compounds, nor the precise function they have in the internal functioning of the plant.

The subject certainly calls to mind the incident in the Qur’an’s account of the birth of the Prophet ‘Isa, upon him be peace. Maryam, the mother of the future prophet, is suffering the pains of labour: ‘And the pains of childbirth drove her to the trunk of a palm-tree. She cried out: “Ah! if only I had died before this! if only I had been a thing forgotten! But it was said to her from below (the palm-tree): “Grieve not! for your Lord has provided a stream of water below you; and shake the trunk of the palm-tree towards yourself: it will let fall fresh ripe dates to you. So eat and drink and cool (your) eyes…”’ (Maryam, 19:23-6).

It is now known that the fruits of the date-palm contain oxytocin hormone, which is an oligo-peptide containing nine amino acids, the principal uterus-contracting and lactation-stimulating hormone. Thus, we can now understand that Allah was directing Maryam to eat the dates in order to encourage the birth and to ease the labour pains and to assist in the production of breast milk for the baby.

The verses can be read straightforwardly as a most moving moment in a moving story, expressive of Allah’s sublime compassion. But our recent knowledge adds to that some intuition of the depth of compassion in Allah’s creation as a whole, its extraordinary subtlety and complexity which by far exceeds the ability of our merely human knowledge to catch up. However, as our scientific understanding of natural phenomena matures we begin to grasp the wisdom of the Qur’an, to see more deeply into the meaning of its Divine Words. It is in that sense that the Qur’an gets ‘younger’ as time grows older.