Many people think of supernatural phenomena as miracles or as divine signs. However, through his studies in biology, the immune system and DNA, Dr. Denis Alexander concludes that what is called natural is nothing less than miraculous. Dr. Alexander, a renowned molecular biologist, is constantly amazed by the extraordinariness of the human immune system. He explores the relationship between science and religion as the director of the Faraday Institute at Cambridge University. Dr. Alexander writes, lectures and broadcasts widely in the field of science and religion. Since 1992 he has been Editor of the journal Science and Christian Belief, and currently serves on the National Committee of Christians in Science and as a member of the International Society for Science and Religion.

M&B: Let’s talk a little bit about your research on the immune system and cancer. Specifically regarding regulatory T-Cells.

Actually, I’m working on the very early stages of T-cell development in the thymus. T-cells, which are the white blood cells that defend us against viruses and bacteria, all have to be “educated” in the thymus. They have this very strict program of education, and then only a very small percentage graduate, so only about 1 or 2 percent of all the T-cells will actually graduate. If you had that sort of system in our own educational system, I think we would look on it as not very successful. If 98 percent of all our undergraduates die, we wouldn’t think that was a very good system. But in the thymus it actually works very well. So what happens is your T-cells learn to only recognize foreign antigens like viruses and bacteria – things that are going to invade your body – and they won’t attack your own tissues. That’s the kind of education that the thymus gives. It’s really a wonderful, amazing system.

M&B: What is the specific role of the T-cells and how is it related to the functioning of other elements within the immune system?

Well, basically the whole immune system is highly complex, so T-cells are not the only cells around. You have B-cells, you have natural killer cells, you have whole sets of different types of cells, and they’re all doing different jobs. They all have to cooperate together.

Then you have killer cells, or K-cells. These natural killer cells are those which are involved in the immediate reaction of the immune system to antigens once they attack your body. So the body is set up so you have an immediate response system, whereby-it’s like mobilization of an army-you can mobilize small bits of your army in the first 24 hours. That’s the natural killer cells. They will give you immediate defense. You have helper T-cells that help the B-cells in order to develop and to make antibodies. B-cells give you your acquired immune system, which is the immune system that only comes into action after about 10 to 14 days. So, that’s the mobilization of the full resources of your army. Thinking of it in terms of a kind of defense system is actually quite useful. T-cells are involved in wiping out virally infected cells, and so they all coordinate together in a rather delicately controlled, complex balance, but they all have to coordinate with each other to make sure the system works properly. It’s amazing how it works; actually, I think, it’s remarkable.

M&B: The natural killer cells attack the cells which are not supposed to be there. But how can they recognize cells that are part of us, how do they define the “self.” Would you give us a parable about how the natural killer cells work?

In the natural killer cell system, there is also the idea of the missing self, which is the idea that when there’s a certain molecule which is not there, natural killer cells won’t attack. Therefore, they don’t recognize our own tissues. This is the idea of the missing self hypothesis. They will only attack things which they perceive to be foreign. It’s like the foreign thing is coming in and waving a flag which says, you know, I want to be attacked, I should be attacked. And that’s set up by a very carefully balanced system, between activating receptors and inhibiting receptors which operate together in order to bring that to pass. It’s quite a complex molecular system, in fact.

M&B: But it still doesn’t provide 100% support. Obviously we are not totally immune to disease.

Now, once the T-cells get out in the periphery, that’s to say the blood stream and the spleen and the other places, in the gut and so forth, then there are other mechanisms in place to keep them under control and to make sure that they don’t actually start attacking your own body. And of course, now and again, very sadly, that does happen. There are mistakes made, and so you get things like diabetes and rheumatoid arthritis and these sorts of auto-immune diseases, and that’s where the T-cells start attacking the tissues of your own body. It’s amazing, most of the time that doesn’t happen, and that’s all up to the thymus, since it educates the T-cells.

M&B: In what way do these cause cancer?

We’re actually working on a mouse model of the human cancer called Lymphoma. It happens when T-cells don’t stop dividing, and so if you look at all the immune cell types of cancers, they’re all very similar kinds of things. Certain cells of the immune system actually undergo errors in the early part of their development, and instead of moving on to the next stage of development they get stuck. Then, they carry on dividing and proliferating, filling up the whole of your bone marrow or your blood stream, and so you end up with white blood cell leukemia.

I could just tell you one example, the one that we’re working on. Basically, what happens is that when normal T-cells get DNA damage, they die. So as a program, when you get any kind of DNA damage, there’s a trigger that happens, and those cells will be wiped out by a process called apoptosis, which is programmed cell death. All of our cells, actually, have the ability to do that. But now and again something happens, an acrogenic change takes place, which is a change in a gene which causes cancer, and that prevents the cells from dying by apoptosis. And so, the cells that have this DNA damage are left to proliferate, and once you get DNA damage, then the chromosomes become unstable, and you get more DNA damage. It’s like a kind of downward spiral. Then all kinds of things happen that cause that cell to become a cancer cells, which will carry on dividing and dividing and eventually kill the mouse, or kill the patient. We’ve just recently identified one of the mechanisms whereby those cells that should die are kept alive, and it’s a very, very subtle mechanism, which is one particular protein, one particular stage of development to t-cells in the thymus.

M&B: We think that dying is a bad thing. But to give an example at the cellular molecular level, “not dying” is actually a bad thing.

Yes, I mean, death is built into our genomes, essentially. You know, we will die eventually because of all kinds of mechanisms, including the shortening of our chromosomes. The cells will only go through a certain number of divisions before they come to the end of their life. There’s a sort of internally clock. Now, of course, it’s possible that we can patch up all these things, we can use stem cells, we can use transplants. If someone needs a new heart or a liver, we give them a new heart or a liver. So clearly we can extend life by years, by decades, and that process is obviously already happening. In fact, I would say that the priority in that way is not to give wealthy people just a few more decades of life, but to try and help those people in lower income countries where what they need is better food and better water, a good water supply, basic medical care, and therefore their average life will then go from 35 up to 65 or 70 years old and so on. So, I slightly worry about this huge activity in the wealthy world to try and make ourselves immortal, and try to extend our life by another decade or so, when such big slices of the world’s population are still lacking even the very basic medical care that I think they should be given. We can extend life by potentially quite a lot, but to become immortal, I don’t think so. I think mortality is written into our genes.

M&B: As a scientist you study the immune system, as well as life and death. But as a person, what do you feel about them? Would you comment on the purpose behind of all these processes?

Well, I suppose that as someone who believes in God, I would see all of these processes that we describe as biologists, as scientists, as part of God’s processes, that part of His intentions is to bring about His own particular ends and purposes on this earth. And clearly, I think one of those purposes is transience. You know, if you have life and death, you have things in process, you also have transience. We’re not immortal-not in our present bodies at least-we don’t display the qualities of immortality. So therefore, I think that fits with the idea of a God who wants to bring in processes which involve life, and they also involve death, and they involve moving on. So we have dynamic systems. We’re not static, we’re not little puppets, you know, who always have the same kind of characteristics. We are in motion, we’re always changing, we’re always moving on. That’s what we see in human society as well as in the whole world of biological diversity. It’s a dynamic process of things, changing processes, which come into being and which go out again, and life and death go together. You know, you can’t have life without death.

M&B: But there is a sense of awe when you think about the tiniest T-cells getting educated. For some people, it would seem amazing and even miraculous as splitting the water with a simple rod, if you don’t mind me saying this.

It is amazing, and I’m constantly amazed and when I look at the immune system, and when I look at the way cells work, when I look at the way, indeed, biochemical signaling pathways operate together. I think that fact is quite remarkable, actually, and should arouse our awe and our wonder, and indeed many people look to God as a natural overall explanation. Not in the sense of replacing God in the gaps of our knowledge, but as our knowledge increases, then our understanding of God’s power and wisdom in creation increases along with that, and to me is real natural theology. Natural theology is not looking for the gaps in our knowledge, but as our knowledge increases coming to a greater appreciation of what God can do. It’s interesting. Actually, just a couple of days ago, I was listening to the account of a Chinese student in Cambridge in the UK, where I come from, and she was telling us about how she had come to have faith in God. What she said was that she was in her biochemistry lectures in the university, and the lecture was about how DNA in each cell, if you stretch it all out, it actually comes to two meters long. You know, if you take the DNA from any one cell, the packing of the DNA is so amazing that when you pull it out, it is two yards long. And she was so amazed by that, she suddenly thought, in the middle of the lecture, there’s got to be a God. There must be a God. It’s so wonderful, you know, she was amazed by this wonderful thing, and she’s moved to belief in God, and I thought that was really quite interesting.

M&B: Do you think arriving to this conclusion has to do with having an open mind, in many ways?

Yes, I think it does. I think the problem is that people brought up in a scientific culture can so often think that the scientific story is the only one that matters. They’re like people reading a book, but they see it and they only look at the black ink on the page, but when they look at the structure of the words they miss the whole message. And I think that’s always a danger in the reductionist approach. Now I’m a reductionist in the methods I use in analyzing the immune system or looking at cancer mechanisms, and that sort of reductionism is very important for us as a methodology we use in our science. But, of course, we shouldn’t then move from that into thinking that reductionism gives us the final story. It just gives us one slice of the story, one little layer of the overall story. I think we then have to take a step backwards and start looking at the message as a whole. That’s terribly important, and it’s always a temptation for people who are deeply imbedded in the scientific community or living in a scientific culture of some kind just to think the scientific story is the only one that matters, but clearly that’s not the case.

M&B: You talked about a sense of awe that surpasses the mind. But when we attribute unexplained things to God, some people tend to think that God is the God of mystery. God is the God of miracles, God of the unknown and the God of the gaps. Would you please comment on this idea?

I think the idea of the God of the gaps is a very unfortunate idea; that has a very long history. Actually, it goes back many centuries. I’m not quite sure when the idea first began. But I think it’s always been tempting as science got going, especially in the nineteenth century when science was less developed than it was now.. It was a temptation for people to try and locate their God within the present gaps of the scientific knowledge. So obviously, as the gaps are closed, so one’s understanding of God will shrink. God is then located in smaller and smaller mysteries.

Now, I think that’s very unfortunate from a theological point of view, because certainly as a Christian I believe in a God who is the author of creation, and who is the author of everything that exists. Therefore, the author writes everything, the author writes the whole book. And it would be very odd if you were looking in the book, if you went to chapter 9 and you went to the second paragraph and you said, “Ah-ha! Now I’ve located the mystery of the author in the second paragraph in chapter 9.” That would be a silly kind of argument. And I think that’s the same kind of argument that the God of the gaps people use. They try and locate bits of the book, forgetting that either the book has an author, or it doesn’t. There’s either someone who is writing the text or there isn’t. So, I think God is in charge of all the processes of the world, upholding and sustaining the whole of the book of creation, if you’d like to use that analogy. So whether we have current gaps in our knowledge now has no theological significance as far as I’m concerned. It doesn’t matter. It’s of no particular interest, so theology has no hidden investments in gaps in our knowledge. It really doesn’t matter. It simply says we’re ignorant about many things. Which is good, because otherwise I would be out of a job.

Interview conducted by Mustafa Tabanli for Ebru TV for the Emmy Award winning television series Matter and Beyond.

The earliest records belong to ancient China. In 1235 Sung Tz’u, a Chinese “death investigator,” wrote a book entitled The Washing Away of Wrongs (translated by McKnight, 1981) in which what was known in forensic science at that time was detailed. In this text, an actual forensic entomology case was recounted, with the best known historic case being given. A murder had been committed in a little village in China. A man had been hacked to death with a rice-harvesting sickle. Because the village was one where rice was grown, everyone possessed a sickle, which meant that there were therefore many suspects. A professor at UC Davis, Robert Kimsey, explains how the murderer was caught; “The local magistrate very cleverly lined up every one of the farmers with their sickles out in the field. He walked up and down the line and pointed to the man who had committed the murder. The evidence he used to identify this man as a murderer-who later confessed, by the way-was the fact that green bottle flies were attracted to this man’s sickle. And nobody else, of course, had green bottle flies on their sickle because the flies were only attracted to a surface that had blood on it. No matter how rigorously you cleaned your sickle, you would still have remnants which these flies would be able to detect.”

Since those times, forensic entomology has made great progress. The way insect evidence helps justice works through the successive colonization of a corpse by a predictable succession of arthropod species. Different types of insects start coming right after death occurs. Organic remains, like flesh, blood, waste material, bone marrow, and hairs all attract certain types of insects. Owing to the time difference between the decaying body parts, the flies arrive at different times. They consume the parts that are nutritious for them and leave the body for another group.

As a manifestation of the divine name Quddus (the All-Holy), dead bodies decompose and nature is kept clean. Thus, the process started by microorganisms is made faster by the insects. Blow flies are among the first group of workers in this respect, whereas the dermestids, for instance, do their duty in the later stages of decomposition. The larvae of dermestids are not found before the body dry outs. The larvae and adults feed on dry skin and hair, as well as other dry dead organic animal matter. Dermestids are a common pest in homes, as well as being undesirable in insect collections and taxidermists collections at museums.

The first month after death is the most effective time for the application of forensic entomology. When death takes place, the insects start to arrive within minutes. However, it should be noted that insect evidence does not always tell us about the exact time of death. But at least we can infer that death occurred at a time that is greater than the age of the larvae that are developed in the body. If we have sound knowledge about the life cycles of the relevant insects, we can make more accurate predictions.

Another thing entomology helps us find out is the location of a murder. Sometimes a victim is moved after a murder in order to get rid of important evidence. For instance, a victim can be taken to a mountainous area after being killed in a town at low altitude. Entomologists can tell you about the habitat of the insects found on the body and give one a good idea about where the murder took place. Many insects live in very special geographical conditions. The altitude, temperature, and vegetation all affect the types of insects that live in the area. Furthermore, a meticulous entomological study will tell you whether the body has been, moved, the season in which it was killed, and whether the murder was committed indoors or outdoors.

Entomologists even help forensic experts with the cause of death. Particularly when the body has already decayed, it can be difficult for the police to determine the cause of death. In normal conditions, insects lay their eggs in certain parts of a body. If there are open wounds however, they will also lay their eggs there. So, if any eggs are found in unusual spots they indicate a probable wound.

When a murder or suicide is suspected to have resulted due to poisoning and if the body is decomposed, toxicological analyses that are made on the insects or the larvae taken from the body can help.

Bergeret (1855), who resided near Paris was the first westerner to use insects as forensic indicators. The body of a baby was found behind the plaster mantle in a house, and an investigation was begun. Bergeret determined that the assemblage of insects associated with the corpse pointed to a state of decay that dated back several years; consequently, the question of guilt was thrown upon the earlier occupants of the house, and not upon the current ones.

Case histories have documented the utility of medicocriminal entomology and point out the unique contributions that this field of science has made. Nuorteva et al. (1967, 1974) presented a series of cases from Finland in which blow flies were used as indicators for indoor as well as outdoor death scenes, and where the immature (larval) or adult stages were used for identification. Leclercq (1969) provided a typical case scenario and outlined how insect data were used to corroborate information obtained from other sources. Bernard Greenberg (1985) outlined several cases, including a description of how laboratory fly-rearing data were used to calculate the number of accumulated degree hours (ADH) required for certain blow fly species to develop, and how such data were applied to the solution of a murder case in Illinois. In another recent case, Greenberg described how the absence of insects in a seemingly straightforward death scene led to a killer’s confession. A window next to the victim had been open when the body was found, thus giving the impression that the murderer had forced entry into the room the night before. However, the air conditioned room was cool, even though it was very hot outdoors. In reality, the killer was known to the victim, had a key, and had returned to “set the stage,” opening the window just prior to feigning discovery of the corpse. The insects thus had insufficient time to colonize the body as the window had been closed prior to the return of the killer. When confronted by this biological reality as pointed out by medicocriminal entomology, the killer confessed.

A Hungarian ferry skipper had been condemned to life imprisonment for the murder of a postmaster, whose stabbed body had been found one evening in September on the ferry. The ferry skipper had arrived at 18:00 that day, and the body of the murdered postmaster had been found some hours later. The autopsy was performed the next day at 16:00. Masses of yellowish fly eggs and numerous newly hatched larvae of 1 to 2 mm in length were present, and the findings were recorded in the autopsy report. No attention was paid to this observation at the trial, however. On assumed evidence, the ferry skipper was condemned to life imprisonment in spite of his swearing that he was innocent. Eight years later the case was reopened. At the new trial, Dr. Mihalyi pointed out that no sarcophagous flies are active in Hungary after 18:00 in the month of September. He also recalled some of his experiments indicating that, at a temperature of 26 degrees Celsius, the yellowish eggs of Lucilia caesar (L.) hatch after 13 hours, those of L. sericata (Meigen) hatch after 10-11 hours, and those of Phormia terranovae Robineau-Desvoidy 14-16 hours after oviposition. These data, when applied to the case of the ferry skipper, led to the conclusion that it was not possible for the eggs to have hatched if they had been laid during the day the autopsy was performed, and that they must have been laid during the previous day before 18:00, since the flies are not active after this time. Dr. Mihalyi’s data on oviposition was verified and, on the basis of this and other evidence, the ferry skipper was released from prison.

Entomology, along with other sciences whisper in our ear that in “the Book of the Universe” there are different signs that lead us to the truth; they are there for us to use if we search for them and fulfill the requirement of causes. This is when the world will open its mysteries to us.

Reference

• http://www.ucdmag.ucdavis.edu/su99/Feature_Bugs.html
• http://www.research.missouri.edu/entomology/chapter1.html#history
• http://folk.uio.no/mostarke/forens_ent/casehistories/ferry_skipper.html
• The illustration is taken from the poster of the annual Insect Fear Film Festival at the University of Illinois, Feb. 2005.