How does loneliness affect your brain?

Spreng et al. The default network of the human brain is associated with perceived social isolation. Nature Communications. December 2020.

A recent study found fundamental structural and functional differences in the brains of lonely people. Researchers examined the magnetic resonance imaging (MRI) data, genetics, and psychological self-assessments of over 40,000 middle-aged and older adults in the UK Biobank medical database. They then compared the MRI data of participants who reported often feeling lonely with those who did not. There were several major differences in the brains of lonely people which were primarily found in what is called the “default brain network,” a group of brain regions that are involved in inner thoughts such as remembering, future planning, imagining, and thinking about others. Detailed analyses of these regions showed that surprisingly, the default networks of lonely people were more strongly wired together and their grey matter volume in regions of the default network was greater. Moreover, bundles of nerve fibers called fornix that connects the hippocampus to the default network were better preserved in the brains of lonely people. These findings suggest that since lonely people are more likely to use imagination, memories of the past, or envisioning the future to overcome their social isolation they strengthen memory-based functions of their default networks through internally-directed thoughts and imagining social experiences. Loneliness has been increasingly turned into a major health problem, as other studies showed that older people who experience loneliness have a higher risk of cognitive decline and dementia. As COVID-19 related social distancing continues, isolation and loneliness could affect our society even more dramatically. Understanding how loneliness manifests itself in the brain at the structural and functional level, and how these paradoxical findings translate into late-onset brain pathologies, would be critical to prevent both neurological diseases and related social problems.

Human-made mass is about to exceed total global living biomass

Elhacham et al. Global human-made mass exceeds all living biomass. Nature. December 2020.

Humanity is rapidly approaching a new milestone in the history of our planet. The amount of manmade objects on Earth will soon outweigh all living biomass. A new study finds that each person alive today produces approximately the amount of manmade mass equivalent to their bodyweight every week. Our daily life objects such as roads, houses, cars, and clothes now weigh in at around 1.1 trillion metric tons, which is equal to the combined dry weight of all plants, animals and microorganisms on the planet. The production and accumulation of manmade objects, also known as anthropogenic mass, has accelerated since the early 1900s. The world’s plastics alone now weigh twice as much as the planet’s marine and terrestrial animals.

About 50% of the current anthropogenic mass is concrete. Bricks, asphalt, metals, plastic, and other materials make up about 19% of the total. Three major problems will arise from the outproduction of antropogenic mass. First, manufacturing consumes resources which will not be available for future generations unless objects are recycled or new raw materials are discovered. Second, even if we can achieve 100% recycling, pollution is generated and energy is used during manufacturing, so resources are still consumed. Third, many of the manufactured items will eventually be discarded which will cause serious disposal issues in the future. This is particularly alarming for the future. Nature is not infinite like so many of us would like to believe. If the current trend continues, anthropogenic mass will grow to three times the world’s biomass by 2040. In the next 20 years, we will generate as much waste as from the last 110 years together. These huge waste flows could lead to massive environmental catastrophes. This study demonstrates the brutal scale and impact of human activities on our planet. Humans are modifying the planet to such an extent that we might have already started a new geologic epoch likely called the Anthropocene.

Drug repurposing by artificial intelligence

Liu et al. A deep learning framework for drug repurposing via emulating clinical trials on real-world patient data, Nature Machine Intelligence. January 2021.

Researchers have developed a machine-learning method that analyzes very large datasets to discover which existing medications could work for diseases for which they were not prescribed. This process is called “drug repurposing,” a popular strategy to find new purposes for existing drugs that offers a rapid transition from research to clinical care. Drug repurposing can lower the risk associated with safety testing of new medications and dramatically reduce the time and money required to get a drug into the marketplace for clinical use. However, discovering new uses for existing medications still requires time-consuming and expensive randomized controlled trials to prove that a drug that is effective for one disorder will also be useful to treat another disorder. To overcome this challenge, a team designed a computational framework that works in two steps. First, it searches enormous patient care-related datasets with high-powered computation to arrive at repurposed drug candidates for a given disease. Second, it calculates and estimates effects of those existing medications on a defined set of clinical outcomes. As a proof-of-principle, researchers decided to focus on repurposing of drugs to prevent heart failure and strokes in patients with coronary artery disease. The edge of the machine learning approach is that it can analyze and compare thousands of human differences within a large population that could influence how a drug will work in the body. These confounding factors such as age, gender, race, and disease severity function as parameters in the deep learning computer algorithm on which the framework is based. This information is streamed from “real-world evidence,” which consists of longitudinal observational data about millions of patients captured by various sorts of electronic medical records. The team used insurance data for more than 1.2 million heart-disease patients. The algorithm analyzed each patient’s drug prescriptions and diagnostic tests for every visit and models input for drugs based on their active ingredients. The model yielded a total of 9 drugs with potential therapeutic benefits, three of which are currently in use and six new candidates for drug repurposing. Interestingly, two diabetes medications, metformin and escitalopram, have been found to lower the risk of heart failure and stroke in the model patient population. This study shows how artificial intelligence can speed up hypothesis generation and clinical trial processes. While this study focused on heart failure and stroke, the framework is flexible and could be applied to most complex diseases.

He is the one who knows the sorrows of broken hearts, who alleviates incurable troubles, and who eliminates the loneliness and depression in our souls with breezes from His realm. Those who turn to Him turn to an opened door; those who supplicate to Him have realized the very purpose of existence.

Those who recognize Him through His works, those who truly know and feel Him through their consciences, need to learn nothing else. In the minds of those who attain knowledge of Him, pieces of that knowledge become crystal domes over diamond pillars. For the souls who do not recognize Him, knowledge is apprehension and all existence we explore with science becomes nothing more than a collection of lifeless bodies.

In the radiant climate of belief, all creation becomes clear as water, from beginning to end; thoughts and events become distilled and everything flows to Him. Those who turn and implore Him with such pure feelings and thoughts are the most fortunate among us.

Given this, wherever we are in the world, whatever the time of day, whenever we feel lonely, let us turn to Him with our whole being, open the doors of our heart to Him, and one by one, confide in Him our sufferings, pains, desires, and wishes, great or small. Then we will feel our pain alleviated, our suffering replaced with contentment, and our souls will be enveloped by the breezes of Divine favors.

Those who confine themselves within the material world will likely never feel Him. Still, with thousands of signs for those who see, He will make His presence felt in our consciences, that He is not distant, and make our hearts smile.

Nights are openings to such inspirations. The souls awakened to the truth, who turn their hearts into bright mirrors shining with Divine epiphanies, wait for blessings to pour on their prayer rugs. We, too, can watch for the surprise blessings of the night, even when we are alone. Such moments can be our time of reunion, when we can stand in His presence and open up the secrets of our heart to Him. Only share your troubles with Him, moan in His presence, and bring your head to prostration, which is the first threshold on the path leading to Him, and wait! Then you will feel doors opening to your heart, one after the other. You will melt under the lights of His being; your respective presence will vanish like a drop falling into the ocean, and in a zone beyond considerations, you will become one being united with the gigantic waves.

The deeper you allow yourself to fall into Him, the deeper the realms that will open to you, and the higher the peaks you will scale. If you set sail to these inner depths with full conviction, you’ll think you’ve skirted the eternity of Paradise, the pristine atmosphere of the realms beyond. With every new step, you will see a different favor of being closer to God.

The souls who see nothing but the material reality and fail to attain the many levels of greatness, magnificence, and inner depth will continue to stagger in darkness, never managing to break free of deprivations and depression.

If only they, too, could feel the depths within their soul, as deep as clear skies and as vast as the universe. If only they, too, could discover the light inside them, and use that light to illuminate the secrets of our Creator’s realms.

Some fail to find these radiant ways which exist as a seed inside them and lead a life unaware of this lofty truth. They fail to blossom and are trapped in physical longevities instead of discovering roads to eternity. I do not know if we should feel pity for them or pray that their eyes open to truth.

Loneliness is a serious public health concern, akin to both obesity and smoking. Why is it not treated as such? Through faith, we can combat this growing crisis.

Loneliness is a state when people are unable to share their inner world with anyone around them. It is very natural that a person desires to be alone from time to time. When this is a short term desire, it can be a means of acquiring harmony with life; however when it becomes chronic, it is harmful for human health. Therefore, solitude is like a sword which has two sharp sides. Solitude in itself is not good or bad; rather the period and severity of it defines if it is good or bad. The severity of loneliness is not measured by how many people that individual has in their social environment; it is measured by how the individual feels in his inner world. In modern societies, loneliness is an important topic of multidisciplinary research, especially in our times due to overuse of social media, as “loneliness” is quickly becoming endemic, threatening our public and individual health.

One of the leading factors behind the increase of loneliness is the spread of immigration, which suddenly tears people from their original cultures and from their families. With the social bonds weakened or broken, loneliness is more severely and increasingly felt. For example according to the 2006 records, 29 million people in the US, a predominantly immigrant nation, were living alone. When compared to the records from 1980, this means a 30% increase in the number of people living alone. Another shocking number is that while 10% of people said they wouldn’t share their personal matters or trust with another person in 1985, this number increased to 25% in 2004.

In our times, loneliness and isolation have become as risky as smoking and obesity. The latest research in neurobiology and clinical research has shown that chronic loneliness has negative effects on the heart, and the immune and nervous systems. Contraction and resistance are much higher in the veins of people experiencing chronic loneliness. Blood pressure rises with the arteries narrowed and shrunk. This makes the heart beat abnormally faster, and this results in the corrosion and laceration of the capillaries. According to epidemiological studies, people who feel alone tend to have shorter life spans and illnesses such as heart disease and depression are at higher risk. They’ve also proven that people socially isolated or feeling lonely are more likely to catch a viral infection.

Studies have shown that, an individual can still feel lonely even though the number of people around them is high. Their social environment, statue, reputation, and property are only of formal assistance and they do not directly prevent an individual from feeling alone. Spiritual loneliness can exacerbate this feeling. Without a deep spiritual life to seek comfort in, they can fall further into depression when faced with problems.

Genetic thermostat and activation of loneliness

There are parts of the human brain which almost work as a thermostat and activate loneliness. Since the information for these parts of the brain are encoded in our genes they are called the genetic thermostat. This genetic thermostat, which we have inherited from our parents, has the duty to adjust the time of response we give to a trigger. Socio-cultural factors and genetic inheritance are assigned to determine the thermostat’s intensity and period of operation. These principles are mostly shaped in childhood and determine the threshold and intensity of the loneliness that is felt later on. In other words, the pain and suffering caused by loneliness depends on the genetic thermostat of the individual. In some genetic structures, the activation settings of the thermostat are low; and in some they are high. Therefore, the feeling of loneliness resulting from social isolation triggers a different response in every person. Even though clinical loneliness does depend on genetics to some extent, it is a curable. Around half of the factors that are behind feeling lonely depend on genes. A study about loneliness conducted on 8,683 twins showed that genetic treatments are 37% effective in treating this feeling. In summary, a departure from our social environment makes us go through different levels of pain depending on our genetic thermostat. Therefore, loneliness is felt in different forms in different natures.

The biological consequences of loneliness

Our body gives out different messages through pain and suffering. In the same way pain and suffering gives us messages of something going wrong in our body, extreme loneliness also has effects on the body, alerting us of something going wrong. Anxiety and physiological changes in our body give out alarming signals when our relationships weaken. These signals warn us that we have to change our attitude and actions in a way that will strengthen our relationships.

It has been observed that stress molecules (cortisol in saliva, adrenalin in urine) increase significantly in people who go through deep phases of loneliness. It was also observed that the body’s sympathetic nervous system, which is responsible for a “fight and escape” response, increased these activities, too. In people who are lonelier, the amygdala is triggered; this further heightens a person feeling of risk. These people are constantly on edge, their “flight” response activated. Therefore, people going through chronic loneliness have very low sleep quality. They wake up tired or even exhausted. They take less pleasure from activities that give rest and bring joy to other people. The degree of their satisfaction and happiness is low. They start losing the joy of living.

Another area of the body affected is the ventral striatum area, which is the award mechanism activated by factors such as food or money, as well as social feelings like sympathy. In a study conducted at the University of Chicago, the activity of the ventral striatum in 23 female university students feeling deep loneliness was measured with magnetic resonance scanning. The study showed that when these females were shown pictures of laughing and happy people, there was a significant decrease in their award mechanism compared to a normal person. So the deep feeling of loneliness locks the award mechanism of the brain, preventing the person from taking pleasure from life, thus leading the person to anxiety and sorrow.

Deep loneliness also affects the activity of the prefrontal cortex of the brain. This is the area of willpower; it brings a limit to activities triggered by instincts, such as eating or drinking. Field studies and surveys have shown that people feeling deep loneliness are more likely to have an unhealthy diet, increase their consumption of alcohol, and live a passive life style without exercising. Moreover, in the management control conducted in labs and that require prefrontal cortex activation, lonely people show little success. The prefrontal areas of these people do not respond fast enough, leading them to little success in these experiments.

Lonely people are more emotionally unbalanced when faced with stress. They find it very hard to control their emotions. They are more sensitive to negative hints when they are among people. They tend to interpret social interactions negatively rather than positively. In one study, the words that address the emotional state of a person were flashed on a computer screen with different colors. Later on, the colors of these words were asked to people feeling deep loneliness and to people who did not feel lonely. People feeling deep loneliness gave delayed answers about the colors of words such as “isolation, rejection, exclusion.” The people who did not feel lonely showed no such delay. This experiment shows that the human brain was created to give alarm signals in case of deep loneliness.

Social bonds and interactions enable a person to be open and accessible to other people. To make this openness and accessibility beneficial is both easy and difficult, simple and complex. People go through periods of wanting to be alone – with themselves or with God – just as they go through periods of desiring more social contact. A healthy person moves freely from state to state. To discover and control this oscillation between the two needs is to learn the best way to manage our lives.

How can deep loneliness be cured?

Since social isolation and loneliness affect people differently, a person should know the nature of his genetic thermostat and should make an effort to stay at his individual comfort zone. Every person has zones or intervals where they feel comfortable expressing their emotions, ideas and attitudes. Similarly, every person has different zones and thresholds for loneliness. Every person needs to understand their limits. Just as our fingerprints are unique, so, too, is the amount of solitude we need.

For those already suffering from loneliness, one of the best cures is a change in point of view. In other words, loneliness is cured by changing the person’s focus from the negative to the positive. People lead better lives when they adhere to the maxim, “Those who attend to the good side of everything contemplate the good. Those who contemplate the good enjoy life” (Nursi, The Letters, Epigrams – Seeds of Truth). People who understand and practice this in their lives have obtained the key to happiness.

A deep, personal relationship with faith is also a major cure for loneliness. Friends and earthly occupations only give comfort to a person until the grave. If the person who is isolated has very solid spirituality, and has acknowledged God as his real friend, he never undergoes a feeling of loneliness that would otherwise destroy his health. With faith and hope, the dungeon of loneliness becomes a school of imprisoned Prophet Joseph. Faith reminds him: “If you want a friend, God is sufficient. Indeed, if He is a friend to you, so is everything. If He is pleased with you, even if the whole world is displeased, it is of no consequence” (Nursi 23rd Letter, 21st Gleam). Sorrow, grief, sadness will not stop by you. Even if they do stop by you, they are bearable since they come from Him. They turn into worship by activated patience. Through faith, a person can achieve fulfillment in both this world and the next.

References

• Miller, G. 2011. “Why Loneliness Is Hazardous to Your Health.” Science. Vol. 331. 14 January, pp. 18-140. www.sciencemag.org
• Cacioppo, J. T. and Patrick W. 2008. Loneliness: Human Nature and the Need for Social Connection. W.W Norton Company. New York.