The findings in mice imply that humans might also possess similar characteristics. This increases the possibility and brings hopes of having a baby even at older ages along with treatments in the future, just like in the miraculous story of Prophet Abraham and Sarah as narrated both in the Qur’an (ad-Dhariyat 51:24-30) and the Bible (Genesis 21:7), showing us one aspect of the possibility and ultimate limits of knowledge and technology that humans can attain one day so that these miracles can become true, though to some extent, with the advancement of medicine.

Bone borne eggs

An interesting study showed an unexpected source of oocytes in the bone. Study by Tilly’s group at the Harvard Medical School in 2004 showed that cells in the bone marrow of mice could be a source of oocytes that are developing in the ovaries [1, 2]. Their first observation was the expression of genes related to egg cells in the bone marrow samples of mice. To test the possibility of bone marrow cells as a source of new oocytes, they chemically generated infertile mice. Treating mice with two chemotherapy drugs called cyclophosphamide and busulfan causes infertility. Once they treated the mice with these drugs, the mice had extensive damage in their ovaries along with an end in new oocyte production in their follicles. Ovarian follicles are spherical aggregations in the ovaries which periodically produce oocytes. Remarkably, when they transplanted bone marrow from female donors, they found a number of oocyte containing follicles (about several hundred). Interestingly, the appearance of those oocytes were rapid and thought to be due to circulating oocytes originating from the bone marrow and developing as they travel through the blood stream. Although they don’t have the evidence that those cells could be fertilized, findings could lead to fundamental changes in the current understanding of the female reproductive system.

Tilly and colleagues also report that bone marrow and blood transplants could also induce the development of oocytes in a genetically infertile mice model (which has a mutation in ATM gene) [3]. This mutant mice lack follicles and developing oocytes and are unable to produce mature germ cells (egg producing cells). Their study shows that bone marrow or blood transplant from healthy donors induces production of oocytes in this mice model. They conclude from those studies that bone marrow could be a source of germ cells to the ovaries throughout adult life. Their findings are somewhat supported by the clinical studies on cancer patients who were expected to be infertile but they could have babies after bone marrow transplant.

Another study on the circulating cells for female fertility used parabiotic (the union of two mice through an exchange of blood) mice model. This study by Eggan and colleagues tested the capacity of circulating bone marrow cells to generate ovulated oocytes and could not show any contribution of bone marrow cells to ovulated oocytes [4]. Blood or bone borne oocytes are highly debatable but bone marrow cells, at least, might have a role in enhancing women’s fertility. This might lead to the treatment of infertility. In addition, it might bring new opportunities for those dreaming of having a baby even at a late stage, but requires much additional research to be realized.

Lab & bone borne sperms

Sperm formation is known to continue throughout adulthood. It involves various steps of cellular differentiations. Maturation of sperms in the body takes more than a month in most mammals. Trials to mimic this complex process in petri dishes failed to demonstrate the production of normal, fertile sperms.

Scientists had dreamed of growing sperms in petri dishes for years. Recently, researchers in Japan developed a technique that allowed production of fertile mammalian sperms in a petri dish [5]. Attempts to make such mature sperms usually failed due to meiosis, a specific type of cell division that halves the number of chromosomes. Meiosis is very essential step for sperm cells to get ready to fuse with an egg. Ogawa and colleagues demonstrated that meiosis of sperm cells lay in a simple change to standard petri conditions. They tried various petri conditions but they ended up with a special serum free medium that is commonly used for growth of embryonic stem cells. Several weeks later, they observed formation of mature sperm cells and even half of them had flagella, a tail-like structure that sperm cells use to swim. Injection of those sperms into egg was also able to produce offspring. In addition, when they used frozen testis tissues of newborn mice, they could grow sperms as well. This discovery in reproductive biology is likely to be beneficial not only for people having infertility problems associated with sperm maturation but also children that undergo cancer therapy which destroys fertility. It is known that chemotherapy impairs fertility. Adults could freeze their sperm before such treatment, but young boys can’t. This new discovery offers such patients hope. In addition, this finding opens new avenues for protection of endangered animals that might die before reaching sexual maturity. It is a matter of time for the same technique to be applied to humans and other species.

There are also reports suggesting the generation of male germ stem cells (sperm producing cells) from bone marrow [6, 7]. Mesenchymal stem cells, which are derived from the bone marrow, have shown to differentiate into male germ cells. Studies testing the effect of retinoic acid and testicular extracts showed to induce human bone marrow stem cells to differentiate into male germ cells as shown by male germ-cell specific marker expressions. Another approach tested the possibility that bone marrow-derived stem cells would differentiate into germ cells when transplanted into the mouse testis. Using GFP positive bone marrow cells transplantations, it has been demonstrated that bone marrow-derived stem cells can also be induced to differentiate into germ cells. Interestingly, there seems to be a connection between bones and fertility.

Bones and fertility

The Qur’an tells the story of Prophet Zachariah, peace be upon him, when he secretly prayed to God to ask for a successor. He said “My Lord! My bones have grown feeble and my head glistens with gray hair from old age…” (Maryam 19:4). His prayer was accepted and the angels came with the glad tidings of his son, John. He was surprised as to how he could have a son while his wife was barren and that he had already reached infirmity in old age. It has been said by scholars that weakness of bones here refers to weakness in engaging in sex due to old age and gray hairs as a sign of infertility. It is also worthy to mention another verse where the creation of human is described as happening from a lowly fluid that gushes forth the vertebra and rib bones: Let human, then, consider from what he has been created. He has been created from some of a lowly fluid gushing forth. It proceeds (as a result of incitement) between the (lumbar zone in the) vertebra and the ribs (At-Tariq 86:5−7). As commentator Ali Unal explains, these verses refer to both the mechanism of the ejection of the seminal fluid and where it is emitted [8], which is a relatively recent discovery in biology. Remarkably, the Qur’an mentions two major bones where this fluid is emerging. Our current knowledge in medicine do not say anything about the role of ribs in reproduction or fertility but both the Islamic and Judeo-Christian traditions mention the creation of Eve from Adam’s ribs, peace be upon him. Could this refer to the relation between bones and fertility? God knows best. Lastly, it is of importance to note that one of the symptoms of menopause is the loss of bone mass. Isn’t it amazing how mysterious events regarding bones and fertility are taking place beyond our control and knowledge?

Ali Fethi Toprak is a PhD candidate at University of Texas Southwestern Medical Center.

References

1. Johnson, J., et al., Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature, 2004. 428(6979): p. 145-50.
2. Vogel, G., Reproductive biology. Controversial study finds an unexpected source of oocytes. Science, 2005. 309(5735): p. 678-9.
3. Johnson, J., et al., Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell, 2005. 122(2): p. 303-15.
4. Eggan, K., et al., Ovulated oocytes in adult mice derive from non-circulating germ cells. Nature, 2006. 441(7097): p. 1109-14.
5. Sato, T., et al., In vitro production of functional sperm in cultured neonatal mouse testes. Nature, 2011. 471(7339): p. 504-7.
6. Hua, J., et al., Derivation of male germ cell-like lineage from human fetal bone marrow stem cells. Reprod Biomed Online, 2009. 19(1): p. 99-105.
7. Lue, Y., et al., Fate of bone marrow stem cells transplanted into the testis: potential implication for men with testicular failure. Am J Pathol, 2007. 170(3): p. 899-908.
8. Unal, A., The Qur’an with Annotated Interpretation in Modern English. Vol. Qur’an 86:5−7, 51;24−30 and 19:4. 2009.

With a similar theme, Mirkena Ozer portrays how pivotal a mother is in a family. In a touching poem, Ozer outlines a typical mother with “eight arms,” mother as the pediatrician at home, and mother with paradise lying under her feet.

It has always been a forged image of Islam that it spread across the world with sword and bloodshed and nothing else. Paul Kearns’ piece “The Spread of Islam” in this issue provides a detailed analysis with a fair approach of the motivations in Muslims’ mobilization from the early seventh through the late seventeenth centuries. This mobilization was so powerful that “in less than one century after the death of the Prophet Muhammad in 632, Muslim rule covered more of the earth than had the Roman Empire at its peak.” Could this only be done with a sharp blade? Kearns notes that “the spread of a religious or ideological ideal can only be truly successful if those whom it is trying to gain submission from are disillusioned or unhappy with their own contemporary world. … We find that a great number gladly adhered to the conquering Islamic rulers and Quranic law as they found protection and benefits that had not been attained under Byzantine rule.”

The lead article in this issue touches on the rise and fall of nations, perhaps expounding on Kearns’ analysis of Islam’s spread from a cosmic sense. In addition to “successive turns of prosperity and hard times,” leaders of nations play a significant role as they sway back and forth, sometimes with “religious devotion and piety, yet at other unfortunate times captured in the web of materialism with no righteousness, morality, or character.”

We are now approaching the end of the series of organs that told you about themselves. They have been pointing out the seal of God on them, and celebrating themselves as they manifest the beauties and the delicacies of God’s art. Thus, they have not only expanded your knowledge, but also guided people to the truth of God’s Oneness, stressing that natural and biological causes alone can never be an explanation for their splendid creation.

Each of your organs told you about its perfect structure and how it functioned within your body system. Let us think that each organ is a musical instrument. No matter how splendid and artful a musical instrument is, its true value is understood only among other orchestra instruments as they perform a wonderful concert. Your body is like that orchestra, where hundreds of instruments play together. In addition to the perfect structure of each organ, more importantly all the organs have to work together perfectly as a team. The success of an orchestra depends on how the instruments play in harmony with each other. The conductor of an orchestra is the person who ensures that harmony. The orchestra members carefully watch the conductor and play according to his arm movements, sometimes louder or softer, sometimes pausing or breaking into a very loud introduction. That is how a perfect concert can be performed.

In order to achieve such harmony, the organs in your body need a system that works just like a good orchestra conductor. This “regulating system,” which has to maintain the perfect harmony and order of the ongoing activities in your body, has two sub-units: One is the brain and the nervous system, and the other is me; your endocrine system (hormonal system). Since I work as a system that consists of many organs, from now on I will refer to myself as “us.” Each of us adjusts itself to the whole system by carefully watching the movements and works of the other organs. At our head are the brain and nervous system, which act as the general control center. However, it cannot carry out the regulating and controlling task alone; it needs our help.

The most basic principle that your body has to follow in order to maintain its health is keeping the inner medium stable in a dynamic balance while responding to varying environmental conditions properly. This is also known as homeostasis. For the inner medium to be kept stable, it is first of all important to be aware of the changes that are happening in the outer world, which is initially done by your sense organs. The signals related to the changes in the outer world are sent to your brain and nervous system through the sense organs. Afterwards, the signals are evaluated, and then they are sent to the related organ so that the proper reaction is produced and the inner balance can be regained. While all the activities regarding growth and reproduction are carried out, the inner medium should be kept stable at the same time (homeostasis). In order for all these activities to be performed continuously, you need inner secretion glands, which are small, but highly important.

The most important of all your organs that constitute the endocrine system is called the Pituitary (hypophysis) gland, which is recognized as the commander of all these organs and situated in your brain. The other secretion glands included in my system are the thyroid, parathyroid, suprarenal (adrenal) gland, epiphysis, pancreas, testicles, and ovarium. Now, these small but very important organs of mine will respectively talk about themselves and demonstrate the perfect program and the sensitive balance within which they work. You are the one who will draw the necessary lessons from this.

In all tissues, there are specific recipient molecule groups that respond to a particular hormone. Each hormone is programmed to stimulate its target cells, which contain those special recipient molecule groups that start doing their specific work. The principal functions of my endocrine system are: to enable growing; to regulate the necessary reproduction process in an ordered manner; and to carry out the physiological processes in the body in a relatively stable medium. I guess your amazement, admiration, love, and apprehension will increase when you hear about my secretion glands. Now, here comes the hypophysis.

My name is Hypophysis (the Pituary Gland)!

I am appointed as the commander of all your glands. Therefore, I am situated in a very firm place at the lower brain. I am an organ that is as small as a bean and that weighs only a few grams, but I have got so many talents. I have two parts. The first is my frontal lobe (adenohypophysis) which secretes most of the hormones. Our Creator has given key roles to the hormones of my frontal lobe to direct secretion activities of other endocrine glands. For example, thyrotropin hormone is arranged in such a way that it affects the thyroid gland and stimulates it for secretion. The unbalance in my thyrotrophic secretion affects the function of Thyroid gland negatively. If it is secreted too much, hyperthyroid; if it is secreted too little, hypothyroid illnesses emerge. In both cases, some problems occur during metabolism. Adrenocorticotropic hormone is created to arrange the activities at the adrenal cortex. Follicular stimulating hormone has two very important roles. The first one is regulating the secretion of estrogen, which is one of the female hormones. The second one is maintaining the physiological activities in the maturation of sperm cells in males, as well as the egg cells in females, for the continuation of human generation. The Luteinizing hormone together with the Estrogen stimulates the secretion of other sexual hormones (progesterone and testosterone).

When you were born, you were 20 inches tall. Now you are almost 6 ft tall. Both your height and your hands and feet grew. Meanwhile, your head and body got bigger proportionally. Another important secretion of yours that controls your growth appropriate to your age is somatotropin hormone. If, for some reason, my working balance got deteriorated, and this hormone secreted less, you would be like a dwarf, or some of your parts would be unbalanced with your body and abnormally short. If this hormone were secreted too much, then you would get into gigantism due to abnormally large growth. Together with gigantism illness, several problems occur; i.e., heart and blood pressure problems, muscle weaknesses, and problems regarding immunity and general metabolism.

Other hormones that are secreted from my frontal lobe are prolactin hormones, which help milk glands develop in expecting mothers, and melanocyte stimulating hormone, which stimulates the pigment cells that give color to your skin. However, these two hormones have no relation with the other hormonal glands.

The lipoprotein molecule of my melanocyte stimulating hormone helps the morphine substances, known as encephalin and endorphin, to be synthesized. You can call these two substances naturally inherent drugs. These secreted substances help you to bear several physical pains. The secretion of my hormones has direct relation with your nervous system and psychological well-being.

Although formed in the hypothalamus part of the brain, one of the hormones that is secreted after being stored in my back lobe (Neurohipofiza) is oxytocin, and the other one an antidiuretic hormone called vasopressin. Oxytocin makes the smooth muscles work. In particular, it stimulates the contractions at uterus during labor and delivery, and it also stimulates the secretions of milk canals by making them contract. Vasopressin enables blood vessels to shrink, causes the blood pressure to increase, and also reduces the production of urine by increasing the transition of water to blood through the kidneys. Hence, it prevents dehydration in hot and dry weather. In the deficiency of the secretion of this hormone, an illness called diabetes insipidus will occur and water metabolism will be deteriorated. I have more amazing features to tell, but I should not be selfish. I think it is time for Thyroid to speak.

My name is Thyroid!

I am placed in your neck, right at the two sides of the trachea (air tube) and below the larynx (voice box). I consist of two pieces that are attached to each other with a thin tissue. Inside me, there are many little saccules called Follicules which are densely surrounded by a capillary network. Following their innate program my cells produce three important hormones in the cavities of those saccules. The two of them are thyroxine and triiodothyronine, which contain iodine atoms and the other one is calcitonin. My hormones have highly important impact in your body. Our Lord God has appointed me, the hormones secreted by a very small piece of flesh, with regulating the oxygen use of all of your cells, and thus the speed of your metabolism which all affect your body’s overall performance. In addition to that, I also adjust your cholesterol level by lowering it in your blood. My iodine-containing hormones are vital for children’s growth. In the case of their deficiency, conditions like growth failure, dwarfism and mental disorders appear. If there is not enough iodine in the earth or water, it becomes more difficult for me to produce hormone and I start to work harder, which causes me to enlarge. This is a disease called goiter. When I secrete excessive hormone, your eyeballs become bulged, a disease called exophtalmic goiter or Basedow syndrome.

My iodine hormones and the stimulating Thyrotropin hormones secreted by the Hypophysis work together; they watch and control each other. If I get lazy and slow down secretion, the Hypophysis immediately warns me. If I secrete too much, this time Hypophysis stops warning me and waits for me to “calm down.”

Do you see what a wonderful system I am? Not only between us, but also all other systems have the same feedback organization between themselves and the Hypophysis. The Hypophysis is an organ as big as a chick pea, and we are only a small piece of flesh. Peter, look at the great jobs we are doing! Can coincidence play any role in this, do you think?

Lastly, I will tell a little about Calcitonin, a hormone which works to adjust the calcium level in the blood serum. That is not an easy job at all. This hormone is vital in the healthy growth of your bones; otherwise your bones will empty, get weak and they might even break for no reason at all.

My name is Parathyroid!

As my name suggests (“para” is a prefix signifying alongside of, beside), I am located just behind the Thyroid, consisting of four small parts. I have so many important functions beyond what is commonly known. My foremost duty is to delicately adjust the amount of calcium between your skeletal bones and your blood. Moreover, I am also assigned with controlling the phosphate and magnesium metabolism. In order to do that, I produce a hormone called parathormone. Of course, I have no idea about the chemical composition of this hormone; but I am just doing my job by producing it and working as I am programmed. When the level of phosphate in the urine and the level of calcium in the blood are measured, you can understand whether I am working well or not. The decrease of calcium in your blood leads to the stimulation of your nerves, thereby causing muscle spasms or titanic contractions that occur along with dotage. The healthy function of your heart and muscles highly depends on this calcium. Who knows, Peter, what other functions of me you human beings will discover in the future!

My name is Adrenal gland!

I consist of two little parts located on top of the kidneys, one on each side. Do not underestimate me by just looking at my size! You will be amazed to learn what crucial functions I perform. Each of my parts has an inner (medulla) and an outer (cortex) section. Those two sections differ quite markedly from each other in their structure, functions and in the origin of the embryonic layer where they form. But despite those differences, our God Almighty has put them one within the other. The two important hormones that my inner section secretes are Adrenaline and Noradrenaline. My adrenaline secretion speeds up the conversion of glycogen (in your liver) into glucose, and thus the sugar level increases in your blood depending upon your energy needs. This increases the power and the speed of your heart contractions and constricts the diameter of the blood vessels, thereby causing the blood pressure to increase. I assist in dilation of the narrow bronchioles of your lungs so that you can get more oxygen. When you become nervous, quarrel with somebody, face a danger or experience any stressful moment, I cause all those activities to happen by secreting more hormones expeditiously. That is how I help in protecting your body. All in all, 80% of my secretion is adrenalin, whereas the 20% is noradrenalin. Noradrenaline has less impact on your heart and metabolism.

My cortex (outer section), where steroid types of hormones are produced, secretes aldesterone, cortisol, and some androgens (a male hormone). Aldestrone regulates the water and salt levels (especially sodium and potassium metabolism) of your body. Cortisol meets your glucose needs if you are starving by breaking down the proteins into amino acids; it is also responsible for preventing the infections and allergies. Although the testicles (male reproductive glands) are the main organs that produce the male hormones, I also supply them. My androgens help in the development of male characteristics such as voice changes, beard and moustache growth and hair growth. When women get older, the androgens that I secrete causes the voice to deepen and hair to grow on their bodies.

My name is Epiphysis (Pineal gland)!

I am a small gland that is situated at the roof of the dieencephalon (“interbrain”). As it is most commonly known, I secrete the melatonin hormone. This hormone helps the melanin (the black or brownish pigment that gives your skin its color) to aggregate or dissolve in the special skin cells called melanophore. Thus, it senses the intensity of the light that changes according to the seasons and day length, and adjusts your skin color by lightening or darkening it. Moreover, I work as your biological clock, regulating your sleep-wake cycle. It is also thought that I arrange the different working periods of your organs.

Our Name is Testicles!

We are male reproductive glands. Our God Almighty has created us for the continuation of human generation. Each of us is oval-shaped and located in a pouch that weighs 25 grams and facing to each other. Each of us is protected by a case of skin and muscle. This case extends into our internal part where it is divided into 200-400 lobules. Each lobule consists of fine coiled tubes. The reproductive cells and the sperm cells which contain a group of your genetic program are produced in those tubes.

When you reach puberty, upon responding to the stimuli that comes from the hypophysis, we start to produce sperm, as well as Testosterone, a type of androgen (male) hormone. Testosterone is necessary for your male appearance; it helps in the developing the characteristics that distinguish you from females in terms of appearance.

A special cell division called meiosis is needed for sperm production. Along the layer that make up the walls of the coiled tubes lie the cells that are called Spermatogonium. Each of these contain 46 chromosomes (23 maternal and 23 paternal). As a result of serial divisions and crossover of those cells, new cells are created with new characteristics. From one Spermatogonium, four sperms are formed and each of them has 23 chromosomes.

Each sperm differs from one another, and each of them contains a mosaic composed of the different characteristics you possess. Among the millions of sperms that are produced, not one of them is identical to another. The reason is the interchange of sections between pairing homologous chromosomes (that you take from both your mother and your father) during the process of meiosis. For example, in one sperm, your nose traits that come from your father might come together with the ear traits that come from your mother. In another sperm, for example, the fingers traits that are inherited from your father might come together with the eye traits that are inherited from your mother. When so many different traits can be mixed in so many different ways, you can imagine the great potential of variety for human beings.

We are private organs that some people see as “obscene” to talk about and which generates “dirty” sperm-containing fluid. However, as you have seen, we are given to you as a gift from God, wrapped with so many beautiful meanings, one of which is the important task of continuing human generations.

My name is Ovarium!

Dear Peter! My duty is particularly relevant to women; I am the female reproductive organ. Therefore, I should begin by saying something like ‘I am Jenny’s…’ this time. Just as the Testicles are the male reproductive system, the ovaries are the woman’s organ. It cooperates with the male productive system in order for human generation to continue. We, the two ovaries, are located in the lateral wall of Jenny’s pelvis, one on the left and one on the right, and we measure approximately 1x 0.60 x 0.60 inches and weigh between 4 and 8 grams. Even before Jenny was born, we contained an amazing 150–500 thousand immature egg cells inside us.

During childhood, the follicles which contain the eggs diminish continuously, and by the time a young girl reaches puberty, only 35,000 of these follicles remain in each of her ovaries. Throughout the woman’s reproduction lifespan, usually between the ages of 13–50 years, a mere 300–500 of these follicles actually transform into mature eggs. You will certainly realize that you have reached puberty when I begin to produce the estrogen and progesterone hormones. As the estrogen I produce stimulates the development of the female’s sexual characteristics, progesterone prepares the wall of the uterus, making it more receptive to the implantation of a fertilized egg. If the egg I produce is not fertilized by sperm, every month (in approx every 28 days), it will degenerate and then be discharged from the body together with the lining of the uterus during menstruation. Then another one of my eggs matures, and patiently begins to await sperm.

The principle event of chromosomal change in my eggs and their diminishment in numbers is the same in the development of sperms. The only difference being that every spermatogonium produces four sperms, whereas only one mature follicle is produced from the mother cell (Oogonium) that produces my eggs. The remaining three are degenerated. You would have thousands of eggs awaiting fertilization if this was not the case. However, due to the fact that your bodies are not capable of harboring and protecting so many eggs, our Creator provided you with the mechanism of reducing the number of these eggs, and therefore relieved you of any difficulties.

I must take this opportunity mention another two of my organs, one of which is the pancreas, who described itself previously (see The Fountain # 67). As you may recall, the pancreas is a compound gland. The pancreas previously described how it produces digestive enzymes, and also how it produces insulin and glucagon to deal with the metabolism of carbohydrates. As this is a very complex organ, we allocated the pancreas the opportunity to describe itself and explain its functions in a previous edition of the magazine. For more information you may refer to the issue listed above.

An organ which is a part of your immune system, and also considered part of the endocrine system, but an organ you are probably unfamiliar with, is the Thymus gland. If the immune and lymph systems feel the need to describe themselves to you in the future, the Thymus gland will inform you that it resides at the same level as your heart, behind your breastbone (sternum). Then it will go on to define its specific duties. But for the moment, the only thing I am going to inform you of is the most important duty of the Thymus gland.

The Thymus gland produces soldiers called T lymphocytes (T cells) and special antibodies which fight the invasion of diseases, illnesses, and also attack cancer cells and any foreign antigens. The Thymus gland is recognized as a part of the endocrine system because it produces hormones and antibodies. The special lymphocytes and antibodies that are produced in such a complex process by other organs of the immune system are transformed into T cells as they pass the Thymus gland. Then, gaining new characteristics, they secrete specific hormones which in turn stimulate the development and differentiation of T lymphocytes.

Whatever the system may be, the Thymus gland, to the contrary of other organs, is at its largest and most active during the embryonic and neonatal periods. During adolescence, the Thymus gland begins to shrivel and shrink, and continue to shrink gradually into old age. The reason why the Thymus gland is large during the early stages of life is because it must constantly generate new antibodies to enable the body to fight against new germs and diseases, which the body encounters every day.

I may have extended the topic slightly this time because every organ of my endocrine system described themselves individually, and then we got onto the subject of Jenny’s special case, as wel as the different aspects of Peter’s case. All the organs I mentioned today are small, but as you may have noticed, these small organs behold great mystery and wisdom. In addition to this, all of these organs’ individual duties are connected, in particular the Pituitary gland (Hypophysis), and have been arranged and regulated in such a way that they control one another. Can such a magnificent hormone system and bodily activity working in such harmony be explained as a mere coincidence?

Irfan Yilmaz is a professor of biology at Dokuz Eylul University, Izmir, Turkey.

The Qur’anic descriptions and those in the Hadith are remarkable for their accuracy in relation to what is known about the subject now. But, what was known then? Until 1688, among Muslim as well as European scientists, the Aristotelian account dominated, no one daring to question it. The two theories in Aristotle’s time were: (a) the embryo is preformed as a miniature in either the male semen or the female secretion and then grows in the womb; and (b) the embryo is actually formed and created out of the menstrual blood. Aristotle favoured the second view, adding that male semen caused the menstrual blood to coagulate, like milk curdling into cheese. The Qur’anic description tells us, by contrast, that (a) the embryo is not pre-formed but grows in successive stages (71.13-14, 23.12-14,22.5); and (b) is formed equally of male and female fluids (76.2). The relevant ahadith re-state what is in the Qur’an. Interestingly, while exegetes of Qur’an and Hadith did not fall into error in their account, many Muslim scientists and doctors, under the spell of Aristotle, repeated Aristotle’s (incorrect) view. Thus, about 700 years after the Revelation, Ibn Hajar al-Asqalani commented: ‘Many of the anatomists claim that the semen of the male has no role in creation of the baby. Its role, they claim, is limited to curdling the menstrual blood… The saying of the Prophet denies what they say. The semen of the male actually participates equally to that of the female in formation of the embryo.’

The pre-formation theory lasted in Europe into the 18th century when it was believed that a full miniature existed either in the female ovum or in the male sperm, then simply got bigger in the womb. This theory was destroyed gradually and was no longer held in any form after 1900. Von Baer (1829-37), called the ‘father of embryology’, identified the human ovum. Subdivision of the egg, i.e. growth of the embryo in successive stages, was properly demonstrated and understood in 1839 by Schwann and Schleiden. And in 1875, Hertwig described the fertilization of an egg by a sperm. Then in 1883, Von Benden showed that male and female cells contribute the same number of chromosomes to the embryo.

However, not until this century, have a number of discoveries established how and when the sex of the embryo is determined; how and when the hones and musculature, the organs of sight and hearing, the nervous system, and so on, develop. It is rather more than remarkable, therefore, that in Qur’an and Hadith we should find unmistakably accurate and detailed references to these matters.

The earliest of the successive stages of embryo development is the nutfah, in turn distinguished as male and female nutfah (in modern terminology, gamete), the two being commingled to form the nutfat amshaj (zygote). The Qur’an clearly and explicitly states (75.3(t), 53.45-6, 59. 58-9) that the sex of the embryo is carried in the fluid ejaculated by the male (X or Y chromosome in the fertilizing sperm). Also, in the Qur’an s emphasis that growth is from a lucre drop of fluid, we find a clear pointer to the fact that the spermatozoa make up a mere 0.5% of the ejaculated fluid, in which tiny quantity are carried an average 2 to 300 million individual sperms.

The nutfat amshaj (zygote) develops into ‘alaqah (that which clings) which attaches itself to the uterine wall. The stunning precision of the term ‘alaqah for the detail of how the zygote attaches, implants and is nourished in the womb, is striking in Dr Albar’s account. (For even more on the detail, see Sikander Hussain ‘Al’Alaq: the mystery explored’, Ark Journal, London, 1986, pp. 31-6.) The ‘alaqah is transformed into mudghah (chewed lump), the somite(s) from which hones and muscles are subsequently differentiated. The mudghah stage includes also the pharyngeal arches (out of which face, ear and neck are formed) – the marked indentations give the embryo the look of a ‘chewed lump’. The Qur`an’s allusion (22.5) to mukhlaqa and ghairu mukhlaqa, formed and non- formed development of the mudghah, is now readily understood as the critical period of organogenesis, when the embryo is most susceptible to factors which can cause congenital malformations. The Qur’an says (2.259): kayfa nanshuzu-ha thumma naksu-ha tahma, ‘how We erect them (the bones) then enclothe them in flesh’. Nanshuzu-ha, here inadequately rendered ‘We erect them’ is as informative as any modern textbook description, for example ‘With time a number of needle-like spicules are formed which progressively radiate from the primary ossification centres towards the periphery.’

The pre-formational aspects of embryo development are now understood as hereditary characteristics contributed by parental genes. In the Qur’an (81). 17-19), the nutfah (male and female gametes) is said to carry these predetermined characteristics. There are several ahadith confirming this reading. One, in the Sahih of Muslim, explicitly mentions 4O -42 days after fertilization as the moment when the angel enters the womb and ‘gives the nutfah its shape and form, creates its hearing and visual apparatus, builds up the hones, the muscles and forms the skin. He then asks, 0 God, is it a boy or a girl, what is its livelihood and what will be its lifespan? God gives His answer and the angel writes all that will come. ‘The textbooks tell us that ‘In the sixth week of development the Primordial germ cells invade the genital ridges; if they fail to reach the ridges, the gonads do not develop..’ The site of formation of the gonads is indicated in Qur’an 86.5-9 as ‘between the backbone and the ribs’. This is exactly right. Once formed the gonads differentiate into either male and female and make their progress in the body accordingly. Blood and nerve supply and lymph drainage remain connected, even in the adult, to the area ‘between the backbone and the ribs’.

In this review only a few of the great many correspondences between the Quranic text or ahadith and current knowledge about human embryo development have been mentioned. What is the point of noting these? Almost all of these Qur’anic verses have as their general context a reminder of the resurrection. The re-creation of individual human life after death. We are confronted with the fact of life as a stunning miracle of the Mercy and Omnipotence of the Creator. Knowledge of the successive stages of growth from the near-nothing of a spot of bodily fluid cannot but create a sense of awe at the responsibility one carries for the miracle of one’s life. And one carries it hack to Him whose care initiated, ordained, proportioned and sustained our life – the contrasted human contribution being that drop of ‘lowly fluid’. Then, what – except perversity – could allow us to doubt that the Creator has concern for how we use our lives, or doubt that He can and will bring us again to life so that we may ourselves understand fully the worth of our intentions and actions? Also, these verses, urging a meditation upon the fact of life rather than upon the fact of death, educate a positive temperament, a positive attitude. Religious responsibility can be awakened by reflecting upon the wonder of birth, as much as by reflecting upon the mystery of death.

No textbook about human embryo development can inspire reflections of this kind. Of course, it is also of the utmost importance to know that the information in the Qur’an, given in words which are extraordinarily precise and yet remain generally intelligible, is accurate. Most non-Muslims do not believe that the Qur’an is the Book of God verbatim, as Muslims believe. In trying to make sense of the phenomenon – so copiously illustrated by Dr Albar from the field of human embryology – of how so much accurate knowledge is there in the Book, they may be led to question the assurance with which they hold to their non-belief.

It was 1927. The warm days of spring had arrived in the beautiful village of Bark. The fine weather brought visitors from distant lands. One special guest would enjoy the long tranquil summer. She would nest in a high chimney near the mosque and wake to the voice of the muezzin calling the faithful to prayer and then recite her own long ballad. The sounds echoed through the hills. There was a longing sound in her voice. After mating and giving birth, the majestic visitor would normally have returned to her homeland to maybe come back the following year

The stork’s hopes were as long as her thin legs and protracted beak. She was young and beautiful and attracted the eye of a strong and handsome male. After their wedding, held in the deep blue sky, they flew away to build a new life together. The protective male proudly and jealously looked after her. She made her nest and began to lay her eggs one by one. The male counted them every day and protected them carefully. They anxiously awaited their chicks. But something happened. A mischievous hand interfered with the eggs. It was not a child. It was a cunning adult. He examined the eggs, and chose the best one. He stared at it and laughed through his rusty teeth. Holding his hat so as not to lose it to the wind, he climbed down from the tree, his evil prank completed.

He rushed to the coffee house and began to boast about what he had done. He had replaced the stork egg with a duck egg. With a cigarette in one hand and the egg in the other he bragged: ‘I took this egg and put a duck egg in the nest. Soon, we will see flying ducks’.

He returned home and showed off the egg to his children. They looked at it in astonishment. He put some butter in a pan and prepared to fry it. It sizzled as it struck the hot metal. At that very moment, the heart of the mother sizzled as she was struck by a burning desire to return to her nest. Like the man, they too returned to their nest to look after their young. Unaware of what had happened, the male sang his beautiful song and eased the worries of his mate.

Waiting for a new life is not easy. The male stork flew away early in the morning, and after searching near and far would return with all sorts of delicacies for his wife. When the chicks eventually hatched, cracking the shells one by one, she noticed that one was different. They were all cute and lovely, but one was different She looked at it again and again, but could not find any resemblance with the others. Her heart filled with compassion and took pity on it.

‘It grows up with the others,’ she said to herself. What was the difference apart from its short legs and beak? She could not throw it away. It would surely die and a soul would be lost. This poor chick would never survive. She dared not mention it to her proud and handsome mate.

As the chicks grew, the differences became more apparent. The male had not noticed at first and used to watch them all with great pride. Then, one day, he noticed the duckling. Everything changed. He frowned and became angry. He stared at his wife fluffing out his feathers. She understood what this meant and what he was thinking. She shrunk away and was unable to make a sound. She wanted to say ‘I pitied this chick and wanted to protect it.’ but she couldn’t.

The male stork fluttered his wings, rose, and came down on his wife violently this was an infidelity and an insult to himself and his generation. He could not bear it. He could not ignore it. He did not care that the others were not jealous. He was extremely jealous and very angry. Although he loved his wife a great deal, his jealousy turned to hate. A female is beautiful and beloved if she protects the honour of the male. As he struck her, his beak filled with her feathers. She would never leave the chick. She was a mother. She could never do such a thing. He struck her again, more violently this time. Her body bled. With the third blow she looked at her chicks, as if seeking help, but they could not understand what was happening.

He flew away to seek the views of the other storks. They decided. An unfaithful female has to be executed. She made no sound. She was at the mercy of the law. He got his revenge. They took her body to the village square and dropped it there as a kind of warning. The dead stork became a play thing for the children.

The man who had swapped the egg saw it. Now, he wasn’t laughing. A flame burnt inside. He felt a heaviness on his heart. It wouldn’t go away. He took to drink and couldn’t talk to his family. He was overcome by embarrassment at the way he boasted in the coffee house. The villagers became sad upon hearing the yelling of the chicks in the high chimney. No adult dared touch the corpse. The village felt sorry for its guest, but no one would remove her body

The cruel man could not leave his house. He pulled the curtains and took refuge in darkness. The pangs of conscience exhausted him. He could only go outside in the evenings. One night, with a bottle in his hand, he went to the village square. He was talking to himself. The beak of the stork stood upright like a knife. In his drunkard state he lost his balance and fell on it. The beak pierced his heart.

Hostility to Islam and Muslims was an integral part of most of the travellers’ mental makeup. David Roberts, a painter of the idealized landscapes of classical ruins, expresses his frustration in a dislike and hatred of Arabs whose forms litter the otherwise perfect scene: ‘Splendid cities, once teeming with a busy population and embellished …with temples, now deserted and lonely, or reduced by mismanagement and the barbarism of the Muslim creed to a state as savage as wild animals by which they are surrounded. Often have I gazed on them till my heart actually sickened within me.’1

As ‘the idea of travel as a means of gathering and recording information is commonly found in societies that exercise a high degree of political power, the traveler begins his journey with the strength of a nation or an empire sustaining him (albeit from a distance) militarily, economically, intellectually and, as is often the case, spiritually…’2

In 19th century travel accounts, the more routine designation of the Orient is feminine; its main symbols are sensual women, the harem, and the despotic -but curiously attractive- ruler. Moreover, Oriental women, like Victorian housewives, were confined to silence and to unlimited service. The English woman traveller, Miss Irby, who travelled throughout the Ottoman regions, defines the proper place of the oriental women:

‘To the Musulman, a woman was an inferior being, a chattel, to be bought and sold, kept secluded behind the screens of the women’s quarters, or, if produced in public, to be hidden behind the draperies of the litter, or muffled and secreted in long shapeless robes, face covered by the veil; the property of the man as was his dog, his servant, his horse, to wait on his pleasure, to sleep at his feet; yet withal, if the husband be rich, to be cossetted and adorned with jewels and fed with sweetmeats, to spend days in idleness and chatter.’3

In various 19th century Oriental books and tales like Vathek, the Giaour and Don Juan (especially Cantos 5-8) which are more or less fixated on the images of the Oriental harem, the figure of the veiled Eastern girl symbolising the colonial Other is created by a narrative structure in which a male subject’s attempts to liberate a female object from the tyranny of the harem is interrupted or arrested by a stereotypical patriarchal aggressor who prevents the achievement of narrative desire in the possession of the woman. In other words, the Orient is thus refigured as the harem fantasy of European imperialism that shows ‘the East’ as the obscure object of Western desire. The narrative structure of Vathek designates the Orient as a feminized place invaded by the masculine subject.

Reza Hammani and Martina Rieker criticize Ghoussoub’s Marxist approach which deprecates Islam as not good for women. However, they agree that Middle Eastern feminism is vitiated by its involvement in debates whose agenda was set in 19th century travel writing. They develop this idea further with the following explanation:

‘Two issues have dominated Western discourse about Middle Eastern women since the 19th century; the veil and the harem. The harem continues to be treated as a contemporary reality in popular mythology. Thus, Gloria Steiner cites freeing Saudi women from harems as one of her fantasies in her autobiography – we wish her luck in finding a harem in Saudi Arabia. Moreover, it is above all the veil which remains a central preoccupation… The veil is not always imposed; in many contemporary instances women have been instrumental in assuming it. This is not a matter of relativist interpretations but of power… In the case of women in Egypt since Sadat’s Open Door Policy, large numbers of working-class women have themselves mobilized to veil to signify their opposition to the regime.’4

Irene L. Szyliowicz remarks that historians and social scientists arc demonstrating that the traditional portrayal of women in these societies has been biased and based on Western judgements. European ethnocentrism and male chauvinism have combined to account for this phenomenon.5 As she thinks that French travel writer, Pierre Loti’s attitude toward Oriental women is particularly worth studying for several reasons, she points out in her Pierre Loti and the Oriental Woman (1988) that ‘since all the Oriental women essentially support and ratify their Occidental lovers, it is proper to conclude that Loti created these fictional characters as wish-fulfilment fantasies, to simultaneously reinforce and magnify his manhood.’6 When Loti made a speech titled ‘La Femme Turque’ (the Turkish Woman) before a large gathering of European women in the conference on ‘Feminine Life’, he concluded with a message: ‘Open the cages, open all the harems. Yet, don’t open them too quickly, for fear that the young, imprisoned birds should take a frantic flight before knowing properly where their inexperienced and fragile wings will take them.’7 According to Loti’s interpretation of Oriental women, which is quite similar to that of Byron, one might imagine that ‘they could be manipulated easily by their dominating masters, and further, this masculine paradigm presented these women, like their Occidental sisters as actually craving male domination.’8 Eventually, in the case of Oriental or exotic women created by Loti, the reader faces a different form; they are simple, primitive, dependent, often helpless, and they worship the hero as though he was God. ‘And despite the fact that he was still a product of his Occidental milieu and the prejudices with which he was raised, he prided himself on his objectivity toward various lands which he visited.’9

In sum, from the previously quoted remarks by 19th century travellers, it may be concluded that the most general point about travel literature (something also confirmed by Sir John Mandeville’s Travels) is that travel is undertaken for a great variety of purposes; the specific purpose involved in a given case is always, to a greater or lesser degree, determinant of what is noted or considered noteworthy. Consequently, the attention paid by the writer of a travel book is always ideological. A traveller usually comes from somewhere – from a country from a language community, class – and consciously writes the record of his journey for a particular public in the country he came from.10

Notes

1. As quoted in BALLANTINE, J. The Life of David Roberts, R.A. Compiled from his journals and other sources, Edinburgh, 1986, pp. 104-5.

2. KABBANI, R. Europe’s Myths of the Orient, Macmillan, London, 1986, p.1.

3. ANDERSON. D. Miss Irby and her Friends, Hutchinson, London, 1966, pp. 52-3.

4. HAMMANI, R. and RIEKER, M. ‘Feminst Orientalism and Orientalist Marxism’, New Left Review, 170, 1988, p. 93.

5. SZYLIOWICZ, I. L. Pierre Loti and the Oriental Woman, Macmillan, London, 1988, pp.1-3.

6. ibid.

7. ‘Et je dis avec eux, mais non sans inquietude: out ouvrez toutes les cages ouvrez tous les harems. Cependant ne les ouvrez pas trop vite, de peur que les jeunes piseaux prisonniers…’ P. Loti ‘La Femme Turque in Quelques aspect du vertige mondial, Ernest Flammarion, Paris, 1917, p. 182.

8. SZYLIOWICZ, p. 3.

9. ibid, p. 12.

10. PARKER, D. ‘Orientalism and its Problems’ in BOOLE, F. (ed.) The Politics of Theory, University of Essex, John Fletcher.