The 300 to 500 sperms which strive to enter into egg meet with the cell layer (corona radiata) which is being serially positioned around the zona radiata. A liquid is secreted from this zona radiata which punctures the euchromosome¹ placed on tip of sperm. Each of various enzymes set free following the puncture of euchromosome is assigned to overcome a separate obstacle before the sperm. Duty of the hyaluronidase enzyme, for instance, is to puncture the outer cell layer (corona radiata) which is assigned to protect the egg. Resultantly, the sperm passes through this cell layer and sticks onto the zona radiata (zona pellucida). The quasi-trypsin dissolutive (proteolytic) enzymes are employed for overcoming the zona radiata. Only one or rarely two of the few sperms which stuck onto this zona radiata manages to penetrate into the egg. It has been estimated that plurality of sperms around the egg, contrary to their rarity, facilitates their entry into the egg.

The sperm penetrates into the egg with its tail but tail membrane stays outside. The protective membrane of the ovum (zona pellucida) starts diffusing calcium within the very first minutes of sperm’s penetration and resultantly, granules are released, receptors are exterminated and the egg becomes structurally transformed. Consequently, a thick layer is formed over the protective membrane (zona pellucida) for prevention of penetration of another sperm.

Following the sperm’s penetration into egg (cytoplasm), the “fusion” process starts. Fusion is the unification process of sperm and egg cells (pronuclei) each of which are separately containing 23 chromosomes. Thus, construction of a genetical library which is containing 46 chromosomes and being prerequisite of formation (creation) of a new human baby is completed. Afterwards, the first mitotic division gives way to a double-celled zygote and the embryo starts forming while settling into the secure base of the uterus. As the outcoming child is going to be a mixture, i.e., a genuine and particular blend of the genetic codes available in the inherited gene pool, he/she will have resemblance to his/her parents and thus to their reciprocal kins (paternal and maternal grandparents, uncles and aunts and etc.).

Prophet Muhammad and Genetics

Prophet Muhammad, peace be upon him, pointed in his various sayings and explanations to the fact that the baby in mother’s womb carries a number of genetic features (characteristics) which are being inherited from the parents:

When a Jewish person asked Him, “what is man created from?” he replied: “Man is created from a blend (mixture) of zygotes of both man and woman.” Then the Jew said: “Moses as well said the same before you.”²

Prophet Muhammad, peace be upon him, also shed light onto the fact of resemblance or inheritance of character by way of genes:

“Is bathing a must for women?” asked Umm Sulaim to the Prophet.

“Yes, it is a must when her seminal fluid outflows and seen,” he replied.

“Do women have wet dreams?” she asked.

“May God grant you goodness! How otherwise a child resembles to his/her mother?” He replied.³

….

As seen and understood by His above hadith (saying), He who was the great teacher of mankind was the first person who said that women do also see wet dreams.

He has also been the first person who articulated the concept of “dominancy,” which was not understood before 1850s.

He said:

“The child resembles to either side of the parents whose seminal fluid comes to the fore and surpasses the other’s in mother’s womb during the intercourse. If there is an equilibrium, then, resemblance is also in equilibrium for both sides.”⁴

“If, during the intercourse, seminal fluid of the man precedes and surpasses that of the woman, then, the child resembles to the father, and if semimal fluid of the woman precedes and surpasses that of the man, then, the child resembles to the mother.”⁵

“If seminal fluid of the woman surpasses that of the man, then, the child resembles to his/her maternal uncles, and, if seminal fluid of the man surpasses that of the woman, then, the child resembles to his/her paternal uncles.”⁶

In another one of His sayings, He points out to the fact that the recessive characters (features) in the grand ancestorial gene pool would dominantly and collectively emerge after following a couple of generations:

“A man having a blackish baby boy approached and said to the Prophet:

“I am suspecting my wife.”

“Do you have camels?” the Prophet asked him.

“Yes,” he replied.

“Then, how are their colors?” The Prophet asked.

“Red.”

“Is there any one with grey color among them?”

“Yes, there is.”

“Then, where did this grey color come from?” asked the Prophet.

“Presumably from a line of its ancestors,” the man responded.

“Here you are! This child of you is also presumed to be coming from a line of your ancestors,” the Prophet told the man.⁷

Dr. Arslan Mayda is a medical doctor at Sifa Hospital in Izmir, Turkey.

Notes and References

1. An euchromosome zone enriched by lysosome enzymes is noticed on stem of a mature sperm cell. The lysosome enzymes penetrate into the egg cell and impregnate it.

2. Ahmad Bin Hanbal, Aynee, Ramouz Al Ahadeeth, Kanz Al Ummal, Jami’ul Saghir

3. Bukhari, Muslim, Abu Dawoud, Aynee, Ahmad Bin Hanbal.

4. Muslim, Ibn Majah.

5. Bukhari, Ahmad Bin Hanbal.

6. Bukhari, Muslim, Abu Dawoud.

7. Abu Dawoud, Muslim, Ahmad Bin Hanbal, Ibn Majah.

The Qur’anic descriptions and those in the Hadith are remarkable for their accuracy in relation to what is known about the subject now. But, what was known then? Until 1688, among Muslim as well as European scientists, the Aristotelian account dominated, no one daring to question it. The two theories in Aristotle’s time were: (a) the embryo is preformed as a miniature in either the male semen or the female secretion and then grows in the womb; and (b) the embryo is actually formed and created out of the menstrual blood. Aristotle favoured the second view, adding that male semen caused the menstrual blood to coagulate, like milk curdling into cheese. The Qur’anic description tells us, by contrast, that (a) the embryo is not pre-formed but grows in successive stages (71.13-14, 23.12-14,22.5); and (b) is formed equally of male and female fluids (76.2). The relevant ahadith re-state what is in the Qur’an. Interestingly, while exegetes of Qur’an and Hadith did not fall into error in their account, many Muslim scientists and doctors, under the spell of Aristotle, repeated Aristotle’s (incorrect) view. Thus, about 700 years after the Revelation, Ibn Hajar al-Asqalani commented: ‘Many of the anatomists claim that the semen of the male has no role in creation of the baby. Its role, they claim, is limited to curdling the menstrual blood… The saying of the Prophet denies what they say. The semen of the male actually participates equally to that of the female in formation of the embryo.’

The pre-formation theory lasted in Europe into the 18th century when it was believed that a full miniature existed either in the female ovum or in the male sperm, then simply got bigger in the womb. This theory was destroyed gradually and was no longer held in any form after 1900. Von Baer (1829-37), called the ‘father of embryology’, identified the human ovum. Subdivision of the egg, i.e. growth of the embryo in successive stages, was properly demonstrated and understood in 1839 by Schwann and Schleiden. And in 1875, Hertwig described the fertilization of an egg by a sperm. Then in 1883, Von Benden showed that male and female cells contribute the same number of chromosomes to the embryo.

However, not until this century, have a number of discoveries established how and when the sex of the embryo is determined; how and when the hones and musculature, the organs of sight and hearing, the nervous system, and so on, develop. It is rather more than remarkable, therefore, that in Qur’an and Hadith we should find unmistakably accurate and detailed references to these matters.

The earliest of the successive stages of embryo development is the nutfah, in turn distinguished as male and female nutfah (in modern terminology, gamete), the two being commingled to form the nutfat amshaj (zygote). The Qur’an clearly and explicitly states (75.3(t), 53.45-6, 59. 58-9) that the sex of the embryo is carried in the fluid ejaculated by the male (X or Y chromosome in the fertilizing sperm). Also, in the Qur’an s emphasis that growth is from a lucre drop of fluid, we find a clear pointer to the fact that the spermatozoa make up a mere 0.5% of the ejaculated fluid, in which tiny quantity are carried an average 2 to 300 million individual sperms.

The nutfat amshaj (zygote) develops into ‘alaqah (that which clings) which attaches itself to the uterine wall. The stunning precision of the term ‘alaqah for the detail of how the zygote attaches, implants and is nourished in the womb, is striking in Dr Albar’s account. (For even more on the detail, see Sikander Hussain ‘Al’Alaq: the mystery explored’, Ark Journal, London, 1986, pp. 31-6.) The ‘alaqah is transformed into mudghah (chewed lump), the somite(s) from which hones and muscles are subsequently differentiated. The mudghah stage includes also the pharyngeal arches (out of which face, ear and neck are formed) – the marked indentations give the embryo the look of a ‘chewed lump’. The Qur`an’s allusion (22.5) to mukhlaqa and ghairu mukhlaqa, formed and non- formed development of the mudghah, is now readily understood as the critical period of organogenesis, when the embryo is most susceptible to factors which can cause congenital malformations. The Qur’an says (2.259): kayfa nanshuzu-ha thumma naksu-ha tahma, ‘how We erect them (the bones) then enclothe them in flesh’. Nanshuzu-ha, here inadequately rendered ‘We erect them’ is as informative as any modern textbook description, for example ‘With time a number of needle-like spicules are formed which progressively radiate from the primary ossification centres towards the periphery.’

The pre-formational aspects of embryo development are now understood as hereditary characteristics contributed by parental genes. In the Qur’an (81). 17-19), the nutfah (male and female gametes) is said to carry these predetermined characteristics. There are several ahadith confirming this reading. One, in the Sahih of Muslim, explicitly mentions 4O -42 days after fertilization as the moment when the angel enters the womb and ‘gives the nutfah its shape and form, creates its hearing and visual apparatus, builds up the hones, the muscles and forms the skin. He then asks, 0 God, is it a boy or a girl, what is its livelihood and what will be its lifespan? God gives His answer and the angel writes all that will come. ‘The textbooks tell us that ‘In the sixth week of development the Primordial germ cells invade the genital ridges; if they fail to reach the ridges, the gonads do not develop..’ The site of formation of the gonads is indicated in Qur’an 86.5-9 as ‘between the backbone and the ribs’. This is exactly right. Once formed the gonads differentiate into either male and female and make their progress in the body accordingly. Blood and nerve supply and lymph drainage remain connected, even in the adult, to the area ‘between the backbone and the ribs’.

In this review only a few of the great many correspondences between the Quranic text or ahadith and current knowledge about human embryo development have been mentioned. What is the point of noting these? Almost all of these Qur’anic verses have as their general context a reminder of the resurrection. The re-creation of individual human life after death. We are confronted with the fact of life as a stunning miracle of the Mercy and Omnipotence of the Creator. Knowledge of the successive stages of growth from the near-nothing of a spot of bodily fluid cannot but create a sense of awe at the responsibility one carries for the miracle of one’s life. And one carries it hack to Him whose care initiated, ordained, proportioned and sustained our life – the contrasted human contribution being that drop of ‘lowly fluid’. Then, what – except perversity – could allow us to doubt that the Creator has concern for how we use our lives, or doubt that He can and will bring us again to life so that we may ourselves understand fully the worth of our intentions and actions? Also, these verses, urging a meditation upon the fact of life rather than upon the fact of death, educate a positive temperament, a positive attitude. Religious responsibility can be awakened by reflecting upon the wonder of birth, as much as by reflecting upon the mystery of death.

No textbook about human embryo development can inspire reflections of this kind. Of course, it is also of the utmost importance to know that the information in the Qur’an, given in words which are extraordinarily precise and yet remain generally intelligible, is accurate. Most non-Muslims do not believe that the Qur’an is the Book of God verbatim, as Muslims believe. In trying to make sense of the phenomenon – so copiously illustrated by Dr Albar from the field of human embryology – of how so much accurate knowledge is there in the Book, they may be led to question the assurance with which they hold to their non-belief.