“Free radicals” are a special type of atom that have been linked to many age-related diseases. They form as a result of a process called Oxidative Stress, which takes place when an oxygen molecule splits into single atoms with unpaired electrons. The nature of electrons is such that they like to be in pairs and as a result will “freely” and “radically” search throughout the body for another electron to pair with. They could almost be considered romantic if they were not so dangerous!

Their main danger comes from the damage that they cause to cells or cell membrane, proteins, and DNA. Cellular damage occurs when free radicals travel through cells and disrupt the structures of other molecules. The gradual accumulation of them, and the increased damage that builds as more and more of them collect, is what helps cause many of the aforementioned aging diseases. Our body is under constant assault from oxidative stress, and cells may function poorly or die if it occurs too frequently and without proper bodily maintenance.

Free radicals are a waste byproduct that form as a result of various chemical reactions that take place during our bodies’ normal metabolic processes. They are then “dumped,” and their eventual buildup will often harm our bodies much like how factory waste harms the environment However, they are not entirely useless; it is impossible for our bodies to turn air and food into chemical energy without a chain reaction of free radicals. Free radicals are also a critical part of the immune system, as they additionally move through our veins and can confront foreign invaders [1].

What are free radicals?

Understanding free radicals necessitates an elementary knowledge of chemistry.

Electrons orbit around atoms in levels called shells. Each shell is filled by a fixed number of electrons, and when the first shell is full then electrons will start to fill the next shell.

If there is an atom whose outer shell is not full then it may bond with another atom by using the electrons to fill its outer shell. These types of atoms are known as free radicals.

Atoms that have a full outer shell become stable, however free radicals are unstable. They are “desperate” to acquire the full number of electrons that are necessary to fill all of their shells and will therefore react quickly with other substances.

Take the example of oxygen molecules. If they split into single atoms that have unpaired electrons then they too will become unstable free radicals that seek other atoms or molecules to bond to. If this procedure continually occurs, then it will begin a process called oxidative stress.

Smoking, UV rays, air pollution, fast food, pesticides, ionizing radiation, drugs, and inflammation have all been linked to the formation of free radicals. We must be diligent when it comes to understanding how these influences can affect our bodily health, and then fight back with natural antioxidants.

Free radicals are heavily linked to aging

One of the effects of oxidative stress is that it can damage our body’s cells and thus promote many of the diseases and symptoms related to aging, such as wrinkles and gray hair. They will take electrons from other atoms in order to become more stable, a process that may cause diseases or signs of aging [2].              

In 1956, the “Free Radical Theory of Aging” was outlined as a way to understand how exactly our bodies age over time. Everybody ages, and as we age our body loses its ability to fight the effects of free radicals. Over time our bodies produce more free radicals and more oxidative stress, which increases the rate at which cells are damaged and thus can bring about degenerative processes.

Many age-related diseases such as muscular degeneration, certain cancers, atherosclerosis, cardiovascular disease, emphysema, Alzheimer’s disease, Parkinson’s disease, ulcers and all inflammatory diseases such as arthritis and lupus, and many others are linked to free radicals. Free radicals can be found in the food we eat such as fried foods, the medicines we take, the air we breathe, and the water we drink. Free radicals are also found in alcohol, tobacco smoke, pesticides, and air pollutants.

Several studies and theories have been linked to oxidative stress and the buildup of free radicals including: [3]

• Genetic degenerative diseases, such as Huntington’s disease or Parkinson’s
• Age-related changes in appearance, such as loss of skin elasticity, wrinkles, graying hair, hair loss, and changes in hair texture
• Cataracts and age-related vision decline
• Diabetes
• Cancer, which is associated with chromosomal effects and oncogene activation due to the reaction of free radicals [2]
• Central nervous system diseases, such as Alzheimer’s and various forms of dementia
• Cardiovascular diseases due to clogged arteries
• Autoimmune and inflammatory disorders, such as rheumatoid arthritis and cancer

The free radical theory of aging is comparatively new; however, several studies boost its credibility. Researchers focused on cell’s mitochondria, the “powerhouse” that process nutrients to power the entire cell. Experiments on rats, for example, showed a noteworthy increase in free radicals as the rats aged. These alterations coincided with age-related declines in their health. These experiments also showed that free radicals produced in the mitochondria harm the substances that the cells need in order to work properly. This damage causes mutations that produce more free radicals, thus accelerating the process of damage to the cell. This helps explain aging since aging quickens over time. The gradual, but increasingly rapid buildup of free radicals, offers one explanation for why even healthy bodies age and depreciate over time [2].

Antioxidants can stave off free radicals

Antioxidants, molecules that prevent other molecules from oxidizing and thus undergoing oxidative stress, can help to avert the harmful effects of free radicals. They can also decrease or even nullify the effects of free radicals, as they can provide an electron to free radicals and thereby reduce their reactivity. The uniqueness of antioxidants is that they can donate an electron without becoming reactive free radicals themselves.

There is no single antioxidant that can combat the effects of every free radical. Free radicals have different effects in different areas of the body, and every antioxidant performs differently due to its chemical properties. Antioxidants such as vitamins C and E, beta-carotene, glutathione, and plant estrogens called phytoestrogens all scavenge the body and help remove free radicals. Honey can also function similar to antioxidants by removing free radicals. Additionally, selenium, a trace metal that is required for proper function of one of the body’s antioxidant enzyme systems, is sometimes included in this category. The body cannot manufacture these micronutrients so they must be supplied in the diet.

Foods that are rich in antioxidants include citrus fruits such as oranges and limes, berries, and many other fruits that are rich in vitamin C. Carrots are known for their high beta-carotene content, while the soy in soybeans, and some meat substitutes, are high in phytoestrogens. Apricots, spinach, mangoes, pumpkins, broccoli, and eggplants are all also helpful, along with a plethora of other fruits and vegetables [4].

More research needed

A 2010 study on antioxidant supplementation for the prevention of prostate cancer found no benefits. Furthermore, a 2012 study found that antioxidants did not lower the risk of lung cancer. On the other hand, the study found that people who were already at a heightened risk of cancer, such as smokers, actually had a slightly elevated risk of cancer due to antioxidants.

Some investigators have found that supplementation with antioxidants is injurious when people take more than the recommended daily allowance (RDA). A recent analysis found that high doses of beta-carotene, or vitamin E, appreciably increased the risk of dying. One study found that long-term use of beta-carotene could reasonably reduce the risk of age-related mental problems [4]. But perhaps one of the most important discoveries is that antioxidants are unable to “cure” the effects of free radicals completely [5].  

Additionally, we do not yet fully understand why free radicals form in the first place. They may result as an early sign of cells fighting diseases, or that free radical formation is simply a natural expectation that comes with aging. It is not possible to understand them completely without more conclusive research, which should be encouraged considering the significant impacts that free radicals can have upon our bodies.

References

1. https://www.rice.edu/~jenky/sports/antiox.html
2. https://www.medicalnewstoday.com/articles/318652#How-do-free-radicals-damage-the-body
3. http://www.mytruehealth.info/mytruehealth_antioxidants_freeradicals.html
4. https://www.medicalnewstoday.com/articles/318652#Antioxidants-and-free-radicals
5. https://www.medicalnewstoday.com/articles/318652#What-we-do-not-know

It is a natural feeling for many people to want to turn to a higher power when life becomes almost too difficult to bear. “Irritated by Trivialities” is a poem that explores this feeling with a specific focus on the poet’s frustration with people that cause discord and violence in society. He calls upon God to grant him guidance and peace, and to break the monopoly on power that some tyrants in this world have over the innocent.

Mainstream psychology has long been a secular discipline that has shunned most efforts to include elements of spirituality or faith. However, the emerging field of Islamic Psychology looks to combine traditional, Sufi concepts of spiritual health with modern, empirical research on successful psychiatric practices. The result is the formation of the TIIP (Traditional Islamically Integrated Psychotherapy), a manual for clinicians that wish to educate themselves about this holistic approach to mental health.

The complexity of the human body is always amazing to reflect upon, and aging has consistently remained one of the most elusive areas to understand. Recent research has been shedding light upon “Free Radicals,” unstable molecules that buildup in our bodies over time and have been linked to a variety of age-related disorders such as Alzheimer’s Disease and diabetes. It is possible to remove many of these Free Radicals by consistently eating fruits and honey that contain powerful antioxidants, however it is not possible to stave them off entirely or to prevent aging. Still, the healing properties of many fruits are indeed blessings sent to us.

Lastly, we can observe immense complexity and depth within the animal kingdom. Our article “How Do Ants Know Trigonometry?” explores the Black Desert Ant and its exceptional process for finding its way home after successfully scavenging for food. Is it truly possible for such a tiny creature to develop systems so immensely complicated on its own just because it felt like it needed them?

Cherries are grown as one of three types: sweet, sour, or wild cherries. Alongside fresh cherry consumption, cherries are also used in juices, jams, jellies, cherry pies, cakes, ice cream, and so on. Cherries are healthful and rich in minerals. A hundred grams of cherry juice contains 246 kilocalories, 58.3 grams of carbohydrate, 3.12 grams of protein, 1 gram fat, 115 milligrams of sodium, 745 milligrams of potassium, 0.5 milligrams of vitamin C, 64 milligrams of calcium, and 81 milligrams of phosphorus. They are rich not only in folic acids, which play a significant role in producing nucleic acids and in the conversion reactions of certain amino acids, but also in potassium, which is needed for osmosis of bodily fluids and acid-base balance. Ripe cherry fruits have been widely used as a traditional medicine to relieve pain, especially in Western Europe and North America.

Cherries as a rich source of antioxidants

Antioxidants are vitamins, minerals and other compounds found in foods that can slow down the oxidation process. During the oxidation process that our body goes through in order to metabolize fats and glucose so they can turn into heat and energy, the body constantly produces free radicals as a byproduct of normal metabolism. Antioxidants help prevent the damage done to the body’s cells by such naturally occurring free radicals as super oxides. The super oxide exposure of a person weighing 70 kilograms amounts to about 1.72 kilograms on an annual basis.

Free radicals are unstable substances with missing electrons. They seek to balance themselves by stealing electrons. In constant need of electrons, free radicals take electrons from our healthy cells. Damage to healthy cells caused by free radicals plays a major role in the aging process as well as in the onset of many ailments. Antioxidants provide the electrons that these free radicals need so they can leave the electrons from your healthy cells alone. Protecting the body against free radicals’ mass conversion of cells, antioxidants help reduce the risk of various degenerative diseases caused by free radicals, boost the immune system and improve our health.

God Almighty has created all the cells of the body containing complex systems of antioxidants to prevent chemical damage to the cells’ components by oxidation. Our body is created with an ability to produce metabolic enzymes which are extremely effective antioxidant scavengers. However, the body produces more free radicals and fewer antioxidant enzymes after the late twenties. The All-Providing God has granted us many antioxidant-rich food products that may help us maintain a high quality of life, especially as this ability of the body to generate these enzymes fades dramatically with age.

Ranking above most fruits, cherries are an excellent antioxidant food. There are fourteen compounds in cherries with antioxidant properties. These compounds can protect the body against degenerative diseases, including cancers and cardiovascular disease. One of the more powerful antioxidant compounds in cherries is anthocyanin. In just one liter of cherry juice, there are 267–688 milligrams of anthocyanins that also give the fruit its bright red, red, purple, or violet color.

Recently, as awareness has been raised of most fruit and vegetables having natural antioxidants, and that cherries especially are a rich source of naturally occurring antioxidants, the use of such food products has become more common than synthetic antioxidant supplements.

More health benefits

Cherries offer other major health benefits. They contain the powerful antioxidant compound melatonin, which has anti-inflammatory properties and which controls daily circadian rhythms, helping to improve sleep patterns. Alongside their anti-inflammatory health benefits and improving sleep, they also provide pain relief. Research shows that the consumption of an average of twenty fresh cherries or some cherry juice is much more effective than aspirin in reducing pain caused by inflammation, arthritis or gout.

Cultivation, consumption, and storage

Cherry trees grow in a wide range of climatic conditions and are indeed easy to grow from seed. Once the cherry plant has established, it reaches the fruiting stage in several years.

Cherries can be consumed or stored in a great many ways. Alongside cherries eaten fresh or dried or the juice from the fruits, they can also be used in many dishes, especially desserts, jams, and marmalades. While buying cherries, select fresh, unblemished fruit. Besides consuming cherries as a fresh fruit item, they can also be kept in frozen fruit packs or in cans. Cherries that are to be saved can be stored in the freezer in airtight bags. Canned cherries are also available preserved in sugar syrup. Sweet cherries are particularly used in cakes and puddings. Sour cherries are generally candied or preserved.

However, as one’s age increases, most bodily functions peak and then start to diminish. A better aging strategy would be to age in the healthiest possible manner; i.e., keeping the physical and mental functions as sharp as possible, in particular the memory, so as not to lose human dignity in old age.

Aging and Memory

As one ages, reactions start to slow, the speed of understanding and the level of concentration diminish. The precipitous decline of dopamine-containing neurons in the human brain after age 45 is a universal characteristic of the aging process. The nigrostriatal region of the brain is richest in dopamine and undergoes the most rapid aging of any brain area. Age-associated depletion of dopamine also accounts for less noticeable symptoms, like a decline in physical drives and brain functions. These reactions are mostly on a mental or psychological level. In addition to these, wrinkles appear in the skin, hairs gray, and joints become gnarly. Perhaps, most important of all, is that according to recent research carried out on the brain, by the time most people hit 40, their brainpower starts to weaken. This does not mean that people become incompetent, just a bit slower in the cognitive process. This phenomenon is called “generalized slowing” by psychologists. According to James Birren, the Associate Director of the Center on Aging at the University of California, Los Angeles, the first signs of aging appear on tests used to measure mental speed and acuity, in which people count the number of lights flashed on a screen, for instance, or trace a complicated pattern while looking at a mirror.

“But eventually the down-turn affects almost everything we do,” says Birren, “From how fast we hit the breaks when a car pulls in front of us to how quickly we learn new skills on the job or remember old what’s-her-name’s name.”

Then the question is whether the slowing process is unavoidable. According to psychologist Robert Dustman, the answer to this is yes. One of the country’s top experts on aging and the brain, Dustman directs the Neuropsychology Research Laboratory at the Veterans Affairs Medical Center in Salt Lake City. He’s just turned 70 and shows no signs of slowing down himself. “It is true that when we compare 20-year-olds with 60-year olds on almost any test that measures the speed of information processing, younger people on average score significantly better than the older ones,” he says, “But that does not have to be. There is a simple way I can ward off the scourge of slowness,” Dustman says. And the way to do this is to stay in shape.

At first it seems to go against common sense that in some way a mindless act like jogging or striding around a park is relevant to the speed of thinking. But Dustman explains the connection in a very logical way.

Every cell in the body requires a continuous supply of oxygen and nutrients to function at its peak. But surprisingly, no cells need a greater oxygen supply than the gray matter that rests between our ears. The brain, although it makes up only 2% of our body weight, uses up 25% of the glucose and oxygen supply.

Now suppose a person slips out of shape, their heart gets lazy, the arteries get clogged, the blood flow to capillaries slows down, and the oxygen and nutrient supply to the brain falls us. As a result, neurons get less than they need to function properly, the electrical signals slow down, and hence the mind slows down. A recent study shows that blood pressure (or lack of it) is highly correlated to memory; so much so that, a reduction of it causes the memory to weaken.

But getting older does not mean that one must face a full-scale slowdown, Dustman says. The problem is that by 45, when the brain is quickly falling into decline, most of us neglect to perform the activities that keep the arteries open, the heart strong, and blood flowing; namely exercise. Dustman’s own studies suggest that working out might be an antidote. In one of his studies, he ran 60 male volunteers, half in their twenties, half in their sixties, through the standard mental tests. As expected, the younger group had higher mental speeds. But when Dustman looked closely at the older group, he noticed that the ones who were exercising or had remained active had a brain speed that was comparable to that of the younger set.

The tests included actions as simple as pushing a button each time an X appeared in a long string of O’s to memorizing numbers and symbols. “On many measures,” says Dustman “the older men in good condition scored just as well as men 30 and 40 years their junior.” In real life, that is, they could find a number in a phone book or remember that sensible is a synonym for rational.

When one exercise, in other words, the sections of the brain which control movement and balance are fired up, the electrical signals zap back and forth along the nerves from the brain to the muscles and tendons. The eyes, the inner ear, and other sensory nerves all roll into action. The benefits of these can be detected clearly in the brainwaves and electrical impulses recorded by researchers.

Indeed, in Dustman’s study, the older men who were still fit had surprisingly youthful-looking brain waves. They produced more alpha waves, a pattern associated with calmness under pressure, and had steeper peaks and valleys in waves, which signifies an ability to block out distractions. Furthermore, when subjected to a sudden flash of light or a sound blast, they were faster to produce a wave called P-300, which is associated with fast reactions. “People in good shape can really focus,” says Dustman. “They can pen a letter to a friend without the sound of children playing downstairs disturbing them. They can fill out tax forms correctly after reading the directions once.” For someone who’s out of shape, the news is grim. In addition to problems that range from overweight to heart disease and diabetes, the results of a sedentary life style, it turns out that the brain will very likely start to weaken as well. Still, Dustman is optimistic. He once encouraged 42 sedentary people over 55 to exercise (walking or jogging) three times a week. After four months, the aerobic capacity of the volunteers increased 25 % and they scored better on mental speed tests. In light of this study, Dustman thinks that even easy exercise, such as brisk walking can speed up the minds of people after years of inactivity. The time required varies, however. In similar studies, it took about a year to observe an increase in the speed of the brain.

But it is not time that is important here; the goal is rather not to lose brain capacity until a very old age. It would be better if one were always to keep in shape, as it is easier to keep something that works running than to start it up again once it has slowed down. “The real benefit seems to come from making a lifelong habit of staying active,” says Dustman.

It is better to maintain a regular routine of exercises than to start up new ones. Researchers at the University of Illinois compared middle-aged lab rats who padded daily on a running mill to rats who negotiated a complicated obstacle course of rope bridges and seesaws a few times a day. Predictably, both groups got more blood flowing to the brain. But the obstacle-mastering rats had 25% more hard-wired connections between neurons. Assuming the same is true for humans, then exercises which require more brain activity are potentially more rewarding.

Aging and Sleep

The obvious dangers of not getting enough sleep include mental fuzziness, an increased chance of accidents, illness, psychological problems, and decreased productivity at work or school. But Dr. Eve Van Cauter wrote in the prestigious medical journal Lancet that less sleep can actually speed the process of aging. In her informative study, young men who were allowed to sleep only 4 hours each night showed signs of aging in less than a week. Their glucose tolerance dropped considerably, and they started to release cortisol, the stress hormone, at a greater rate than normal.

Sleep offers the body an opportunity to heal and rebuild itself. Pro-sleep nutrients might help in this cause. For example, it has been shown that nutritional supplements containing zinc, magnesium, and pyridoxine (vitamin B6) , among other benefits, help sleep efficiency. A herbal amino acid 5-hydroxytryptophan is another promising sleep aid to use in times of extreme stress. Among sleep promoting herbs from traditional Chinese medicine are ziziphus spinosa (jujube), schisandra chinensis, and bupleurum chinense (Chinese thoroughwax). These herbs seem to relax the muscles and soothe the central nervous system. Sleep is and remains to be the most precious source of energy replenishment.

Melatonin: A God-given Sleeping Pill

Melatonin is a natural molecule made by the pineal gland, which is located in the brain. Melatonin is made from an amino acid called tryptophan. Tryptophan is an essential amino acid, that is, the body cannot make it; we need to get it from the foods we eat. Tryptophan is found in wide variety of foods. As we consume tryptophan during the day, the body converts it into serotonin, an important chemical for the brain that is involved with moods. Serotonin, in turn, is converted into melatonin. This conversion occurs most efficiently at nights.

Melatonin helps to set and control the internal clock that governs the natural rhythms of the body. Each night the pineal gland produces melatonin, which helps us to fall asleep. Research about this molecule has been going on since it was discovered at Yale University by Dr. Lerner in 1958, but recently there has been a great deal more attention being paid to melatonin. About a thousand articles on melatonin are published annually. One major reason is that scientists are discovering that melatonin is not only associated with deep sleep, but also with our hormonal, immune, and nervous systems. Research is accumulating about melatonin’s role as a powerful antioxidant, its possible anti-aging benefits, and its immune-enhancing properties.

Aging and Free Radicals

A free radical is a molecule that contains an unpaired electron through reactions with the essential element oxygen. These molecules “steal” electrons from nearby molecules to complete that final electron pair for stability. Then they are no longer free radicals, but they convert the new combined molecule into a new free radical. In a living organism, this process can cause a chain reaction of severe cellular damage, unless prevented.

The theory that free radicals are agents of bodily destruction is gaining widespread acceptance, as is the value of antioxidants in preventing such an occurrence.

According to the journal Annals of Clinical and Laboratory Science, the excess of free radicals in our body, i.e. “the domino effect”, is a critical factor in many health problems. An interesting and concerning fact about free radicals is that they cause the same reactions within the cells that occur during exposure to radiation. Free radicals released in the body destroy even proteins, the essential constituents of the body that regulate hormones and enzymes and that make up nerves, muscles, skin, and hair. It is usually suggested that antioxidants are used to fight these harmful free radicals. Fruits and vegetables are plentiful in vitamins A, C, and E, the key antioxidants. Polyphenols, which are found in grapes and green tea extracts are potent antioxidants. In fact, scientists have found out that procyanidins are the most promising polyphenols. In Japan, scientists have discovered that they may be 50 times more powerful than vitamins C and E in fighting free radicals. Alpha-lipoic acid, which is soluble in both water and lipids, can neutralize free radicals throughout the body. In fact, alpha-lipoic acid is involved in so many different antioxidant functions that it has been called the “universal antioxidant.” Citrus bioflavonoids and certain fruit and vegetable pigments are also strong free radical fighters.

Deprenyl: An Anti-aging Treatment?

Deprenyl (selegiline) provides selective protection against age-related degeneration of the dopamine nervous system. It is the only inhibitor used in clinical practice. The rate at which dopamine neurons age is quite variable. Before age 45, dopamine levels stay quite stable. Starting at 45, the decrease in average dopamine content in healthy people is linear, at 13% per decade. When it reaches 30%, the symptoms of Parkinson appear.

The sensitivity of the dopaminergic nervous system to oxidizing free radicals has been well established. The protective effect of deprenyl in lessening the neurotoxic effect of the oxidants (6-hydrpxydopa and 6-hydroxydopamine) appears to correlate with increased antioxidant enzyme levels. The increase in the antioxidant level is proportional to the deprenyl intake.

There as yet has been no definitive study of the long-term use of deprenyl in healthy people as a life-extension and cognitive-enhancing drug. But there has been extensive animal research. The lifespan of deprenyl-taking rats is significantly greater than normal rats, in fact, all the control rats died before the first deprenyl-taking rat died. Early research with deprenyl in humans (early-diagnosed Parkinson patients) shows delayed development of symptoms. Deprenyl has also been established as a treatment for Alzheimer’s disease. Eventually, deprenyl has the potential of becoming a general treatment for aging in people above the age of 45.

Conclusion

Although we know for sure that there cannot be an absolute cure for aging, the results of it can be slowed down considerably. Soundness and health of mind are desirable traits for all ages, not just for the elderly. After many years, many elderly people lose much of their memory and mental capacities; this occurs just at the time when they can pass on all their wisdom and experience to the younger generations. Hopefully, with the advent of science and technology, the deficiencies in the brain due to aging can be avoided to a certain extent. The solution lies in a balanced collaboration of modern medicine and traditional natural cures that have been practiced for centuries.

References

• Life expectancy around the world http://www.mrdowling. .com/800life.html
• Peter Jaret, (1997) THINK FAST- from Health Magazine, http://www.brain.com/TFarticle.html
• Ray Sahelian, M.D., (1997) “Melatonin: Nature’s Sleeping Pill,” http://www.brain.com/melatonin.html
• Ward Dean, M.D., and Steve Wm. Fowkes. “Deprenyl: A Universal Anti-aging Strategy?,” http://www.ceri.com/ deprenyl.htm
• Spiegel, K. et al. (1999), “Impact of sleep debt on metabolic and endocrine function,” Lancet; 354 (9188):1453-9.
• Amtoft-Nielsen, J., M.D. (2002), “Researchers Find Sleepless Nights Speed up Aging,” Journal of Longevity, Vol. 8/No.5: 38-39.
• Abraham, I., M.D. (2002). “The Domino Effect – The Cause of Rapid Aging?,” Journal of Longevity, Vol 8/ No. 4: 36-38.