Sometimes, your back itches slightly and scratching it at that perfect spot fills you with an odd sense of happiness. Other times, you notice a biting itch on your arm and a chickpea-like redness shows up there. Oh, those mosquitoes! It is rarely likely to catch a mosquito in the act, and sometimes it even feels as if their bites just appear out of thin air. As you scratch the blister to soothe the itchiness, your eyes scan the room to locate its infamous proboscis. You see it on a wall, plump with the blood it sucked from you. You cannot help thinking: Why do their bites always leave so much itching? Or even, what is the purpose of itching at all?

Itching is an unpleasant feeling we perceive by our skin and mucous membranes, and an occasionally uncomfortable and sometimes very excruciating feeling.

Itching, just like pain, is a sensation intrinsic to our body to protect itself [1].  It is the way our skin “talks” to us. Indeed animals, even fish, itch too. When itched, our skin instinctively and in its own tongue tells us, “There is something that bothers me and I want you to push it away from me immediately!” If it was not for itching, we would not notice a spider walking on our arm. We would not be disturbed by lice and scabies mites or even fungi that settled on our skin, and we would not try to protect ourselves from these pests either.

An ordinary scabies patient has an average number of about 15-20 adult scabies mites on their skin. In the case of Norwegian or crusted scabies, which is most commonly observed among the elderly, the bedridden, people with seriously weakened immune systems, or those who are unable to itch themselves sufficiently, there are thousands of parasites under the thick crusts of the skin [2]. Itching accelerates the blood circulation on the itched parts, and tissues virtually prepare to fight infection by the rushing blood cells and substances [3]. Yet, millions of people also suffer from chronic itching and scratch their itches much more than usual. To understand this, we need to set on a journey from our skin to our brain.

Human skin consists of three layers: epidermis, dermis and subcutis (also known as hypodermis). The dermis layer in the middle makes glove-like protrusions upward into the epidermis. At the top of these protrusions are mechanoreceptors and nerve endings that allow our skin to sense stimulus (such as temperature, sharpness, pressure, vibration, pain, or itching) [3]. With these receptors, our skin functions as one of our five sensory organs and more like an “alarm system” of our body against changing conditions outside. This alarm system has been created so perfectly that each component knows exactly what stimulus to detect.

Previously, it was thought that pain and itching were sensed by the same receptors (nociceptors) and that mild stimuli were responsible for itching while strong stimuli were responsible for pain [4]. Yet, a contradiction existed because while pain triggered an avoidance reflex, itching activated the scratching reflex. In recent years, it was discovered that the receptors (pruriceptors) that perceive the itching sensation on the skin are the free boundary terminations of C-fibers with myelin-free, slow conduction velocity extending in the form of tree branches toward the upper layer of the skin. Furthermore, it was found that the skin cells themselves behave like itch receptors [3, 4]. When we receive a stimulus that induces itching, such as a mosquito bite which leaves anticoagulant substances on our skin, the mast cells in the skin tissue spring to defense against those alien substances. This ensues the secretion of the bodily defense system called mediators, substances that are produced and stored by mast cells as precursor for emergency conditions. Histamine is the most known of these substances and is the most important mediator in itching conditions [5]. Histamine binds to receptors found for itself in myelin-free C fibers that are tasked for detecting itching on the skin. If we consider histamine as a key, the lock that it fits into is on the nerve that senses itching. Thus, the itching nerve is stimulated by histamine.

The nerves receiving this stimulus connect to the spinal cord at their respective levels and transfer the message to another nerve. Each of these transfer processes is mediated neurotransmitters. The last message transmitted to the brain through these nerves is assessed by the brain and labeled as “itching” [6]. The brain determines the coordinates of the itching location and orders the scratching action to the related muscle system. A new journey that conveys messages from the brain to the arm muscles ends with scratching. Considering the swift rubbing action when we feel an ant walking on our face and scratch to push it away, we may value how fast and perfect our brain and transmission system work.

It is also rather odd how soothing itching can be despite its initially uncomfortable feeling, almost as if our body is rewarding us for saving it from a threat. There are several reasons for this contradiction. Scratching causes a low-intensity pain on the skin. Pain and itch are positioned on the skin alternately. The transmission of the sensation of pain is prioritized while the transmission of itching is prevented [7]. Consequently, our brain senses the pain and, in response, secretes the hormone called serotonin to soothe the body. Although this makes us feel relaxed for a short time, the brain continues to transmit virtual sense of itching by connecting to the receptors that are located on the spinal cord along the same nerve path with the receptors for serotonin [8]. This condition, which may be termed as a vicious cycle of itching-scratching, unsurprisingly infuriates patients. Scratching the same area on the skin continuously causes the production of new mediators and oversensitivity of itching nerves, which can thus turn itching into a chronic distress. Chronic itching can often result as a complication from skin diseases such as scabies, lice, eczema, fungal diseases, or drug allergies. It can also result from a systemic disease such as chronic renal failure, cholestatic liver diseases, thyroid problems, iron deficiency anemia, blood diseases and, rarely, cancers [7]. Itching in systemic diseases can be triggered by mediators on the skin but also by neurotransmitters in the intermediate pathway. This kind of itching cannot be controlled by drugs called antihistamines which block the histamine pathway. Sometimes the brain will receive false itching alarms due to post-shingles contraindications or nerve damage in the vertebrae. Such episodes of itching need to be addressed to prevent adverse outcomes. At times, the reason an itch can occur can even be psychological when there seems to be no need for an itch. According to research, scratching activates the brain’s reward center which triggers the addiction mechanism. Patients in that case are thrilled as they itch constantly [9].

As doors in this mysterious journey of science are opened one after another, we discover that nothing has been created without a purpose, including apparently discomforting sensations such as itching, which, it turns out, is how our skin communicates with us!

References

1. Arıcan O. Kasintinin patofizyolojisi, klinigi ve tedavisi Turkderm 2005;39(2):88-97
2. Jonston G, Sladden M. 2005 Scabies: diagnosis and treatment BMJ;17;331(7517):619-22
3. Guyton AC, Hall JE. Tıbbi Fizyoloji 10. Baski 2001.p815-42
4. Schmelz M. Itch and pain. Neurosci Biobehav Rev 2010;34(2):171-6
5. Arck P, Raus R. From the Brain-skin connection. Neuroimmunomodulation 2006;13(5-6)347-56
6. Metz M, Stander S. Chronic pruritus pathogenesis clinical aspects and treatment. J Eur Acad Dermatol Veneral 2010;24(11)1249-60
7. Metz M, Grundman S, Stander S. Pruritus: an overview of current concepts. Vet Dermatol 2011;22(2):121-31
8. Chen ZF et all. Descending control of itching transmission by Serotonergic System via 5-HT1A-facilitated GRP-GRPR signaling. Neuron Vol.84(4) Nov.19-2014

9. Chan YH et all. Brain’s Reward Circuits Mediate Itch Relief. A functional MRI Study of Active Scratching. Dec. 2013

Flies have two wings that are capable of moving independently from each other; these wings go back and forth on a single axis during flight. Technically, the unequal angles of the wings to the abdominal region could have prevented flight. Yet in the case of flies, this abnormal situation is not a hindrance and results in a harmonious wing stroke.

Let’s bring our palms together over our head and then lower them near our legs. How many times can we make this movement in a second? Let’s say two, three, or maybe four times if we are really quick. Flies have the ability to stroke their wings hundreds of times in just a second. There are benefits associated with this series of movements. The surface of the wings and the rear section of the head are equipped with sensitive hairs that are in charge of registering air currents and mechanical pressures and conducting relevant flight data to the brain. The unwanted effects of air currents towards the body surface and wings during the flight are detected via these hairs that house receptors. Thus, the wings are controlled according to the signals arriving from the brain. Therefore, a fly can feel an air curtain (like an insect screen) against it instantly and often times flies away. Sometimes, they also stroke their wings hundreds of times per second to avoid the negative effects of air resistance on the wings. Without these receptors and serial wing movements, the air current would stick to the wing’s surface and would not let the fly, well, fly.

Is it a fly or a plane?

We sometimes witness comparisons between the flight specifications of planes and flies. However, it is a great injustice to the fly to be put in the same basket as a plane. The products of modern technology, such as a plane, are invented after drawing inspiration from the meaningful skills of animals like a fly. It is not possible to build planes with a wing width smaller than 15 centimeters; there are disadvantages to wings smaller than that in terms of generating lift. On the other hand, flies have much smaller and more fragile wing structures (relative to their bodies) and can maintain their flight in a perfect fashion. When a fly extends its rear legs, covered with hairs designed especially for cleaning the wings, and sweeps them over its wings, doesn’t this suggest a fly is more impressive than a plane?

It challenges mountaineers!

A fly challenges mountain climbers by easily moving on the four walls and ceiling of a room – and even on slippery surfaces like glass. What is its secret?

Its ability to stand or walk on the ceiling without being defeated by gravity is possible via some of its organs. The final sections of fly’s legs are like hooks and the tip of this hook is equipped with suction pads. When flies touch a surface, a sticky fluid is secreted from the suction pads. Flies can remain suspended on the ceiling with the help of this fluid. When it approaches the ceiling, extends its legs to the front and flips towards the opposite direction of its approach, it sticks to the ceiling on its abdomen.

The grand architecture in the eye of the fly

Can you complete a jigsaw puzzle of 8000 pieces in a second without any missing pieces? It seems impossible, but let’s accept that you have. Can you fit this puzzle into an area that’s just a couple of square millimeters? It’s not possible for a man of intelligence to pass this test. However, the fly completes this miraculous task every time it uses its eyes in our rooms. We are unaware of the fact that the fly, which draws patterns of colors under the sun light, has such amazing eyes. Its eye is created to contain nearly 8000 ommatidium, which function almost as small eyes. Different areas can be seen via each ommatidium and once images are put together in the brain, the whole picture forms. Through these tiny eyes, shaped as hexagons that resemble honey combs, a fly can see as close as 2 mm – and can even see behind its body! Because of the wise hexagonal design, the ommatidia are placed in the most economical way possible; there are no missing spaces which could cause a lack of clarity. The optical speed of a fly’s eye is nearly 4-10 times faster than the human eye. Flies can see the ultraviolet section of the light spectrum and this allows them to evade predators easily in dim environments. Every time a fly uses its eyes, it’s as if it gives the message, “Look at how miraculously I’ve been created. Do you think that my creation could have been in vain?” Such complexity is an inspiration to scientists as they try to develop new technologies.

One of the features of flies that surprises scientists most is the way they use a neural network of a very limited number of neurons to perform so many complex movements. Biologist Michael Dickinson expresses his astonishment as to how a neural system of such small scale can accomplish all of these features.

Do not ever kill a fly!

Flies consume plenty of energy during flight. A regular supply of oxygen is needed to compensate for the energy they use. Air is inhaled via a constriction of the abdominal muscles when the fly lands on a surface. However, during the flight, air enters via the serial movements of the wings. Air that enters through the openings of the chitin layer surrounding the fly is transported to cells via small channels.

Flies locate their food via their smell receptors. Thus, a fly in the air easily lands on the food source that it detects. The taste organ detects whether the food is an ideal source or not. Usually, their choices of food are human foods, waste remains, and dirt. There are two tubes located in the mouth of the house fly. It sucks liquid food with one of the tubes; saliva containing enzymes is secreted on the food source with the other hose so that digestion is facilitated. A fly secretes plenty of saliva in order to liquefy the solid foods it prefers.

Flies that use dirt and waste as a nutritional source are considered as disease contracting pests. However, this is a major fallacy. Flies are actually the health officers of the ecosystem. They turn microorganisms ineffective as they take in their food; the digestive enzymes that they carry play role in completing this important task. Due to this important task, it should be remembered that killing a fly is very unfortunate. Great scholar, Bediuzzaman Said Nursi, notes that flies are assigned to terminate unhealthy microorganisms and materials.

Scientists led by Prof. Andy Beattie have noticed that flies are resistant to all kinds of dirt, including from meat and manure. He said that these organisms should be super resistant to infections, otherwise they could not survive and that our work to gain antibiotics from them has been partially successful. In fact, studies focused on obtaining antibiotics from flies started in the past century. English and Swedish scientists isolated certain antibiotics from flies in 1930 and 1947. Efforts to isolate antibiotics from flies continue today.

Reproduction in black flies!

Black flies reproduce quickly. In suitable humidity and temperature, eggs start to hatch in just 10 hours. Larvae feed on liquid materials, though they need bacteria living on solid food to convert it into liquid form. Therefore, an acid is secreted inside the digestive track of the fly that can terminate most of the bacteria. Thus, the insect becomes free of bacteria, ready to fly. One fly can lay more than 100 eggs at one time and between 600 and 1000 in their lifetime. They can lay eggs again after just three days.

When looking at the information we have, it’s clear that flies are acrobatic flight masters with mind blowing features. We should abandon the negativity towards flies and contemplate the perfection of creation by considering their many remarkable skills – and working to discover even more secrets about them.

One of the signs of anarchy in a region could be the marching of an army to get a particular situation under control and, if it is indispensible, destroy or suppress anarchists. Similarly, the first response of the body to such uncontrolled growth is the destruction of tumor cells by activating inner mechanisms that lead to cellular suicide (apoptosis). Anarchy is by definition not to accept any border and authority, causing disorder or upheaval. According to twentieth century thinker Nursi, anarchy cuts and throws away norms and laws that organize social life, one by one, thus destroying the order and leading to mischief and rebellion. In addition, anarchism does not consider the rights of any. Analogously, one by one, cancer breaks genetic rules that organizes cell proliferation and eliminates pathways that suppress tumor formation. Thus, it eradicates the order and triggers chaos and malignancy. Again, cancer works against the life of the body without considering the rights of other cells.

Another characteristic of anarchism could be the elimination of its leaders. Thus, once you get rid of the key players, anarchy may not resurface. Likewise, you can use a strategy in certain cancer types where you can specifically target cancer stem cells. As a result, cancer growth could be suspended and it may bring an opportunity to shrink tumor through chemotherapeutical approaches. One such example is the targeting of CD24, a putative cancer stem cell antigen expressed by a minority of adenocarcinoma cells. This cell-based cancer immunotherapy method uses genetically engineered cancer killing T cells, which are directed towards cancerous tissues using chimeric antigen receptors. This is similar to the taking over of trained Special Forces when anarchy becomes malicious and unceasing. Both natural and genetically engineered cancer killer T cells in our body resemble trained Special Forces that patients need to fight against cancer.

Cancer treatments

Cancer is nowadays mainly treated with chemotherapy, radiotherapy and surgery, and to some extent with immunotherapy. The many purposes of chemotherapy include relieving or preventing the suffering of the patient, prolonging the life span, and if possible, completely curing the cancer along with surgery or radiotherapy regimens. Chemotherapy mainly uses cytotoxic drugs that kill cells by attacking one of the main properties of cancer cells—rapid division. Unfortunately, since cancer cells are not the only rapidly dividing cells in the body, chemotherapeutic agents also harm healthy cells. Another fall back of chemotherapy drugs is the lack of specificity that does not provide a therapy against a specific cancer type and their efficacy vary from patient to patient. In these cases, the indispensable path is synergistic use of radiotherapy with chemotherapy.

As its name implies, radiotherapy involves the use of ionizing radiation to kill cancer. It relies on the destruction of dividing cells by introducing DNA damage, which leads to induction of cellular death through apoptosis. Radiotherapy is therapeutically useful in cancers that are localized to one part of the body. It is also useful to prevent tumor relapse after surgical removal such as in breast cancer. However, radiation, which radiotherapy depends on, is itself the potential cause of cancer and leads to various side effects.

Citizens of the body need justice

Chemotherapy or radiotherapy, which harms both healthy and cancerous cells, recalls the practice of absolute justice versus relative justice. Absolute justice requires protection of every individual while punishing the criminals. On the other hand, relative justice is the justice where the rights of one person are ignored for the betterment of the whole. Absolute justice is always the best practice if it can be properly established. However, relative justice may be sought if absolute justice is absolutely out of reach. Current chemotherapy and radiotherapy treatments are like the practice of relative justice, which harms both cancerous and healthy cells. Of course, these treatments are considered as the last resort for many cancer patients but this analogy regarding absolute justice toward cells in the body urges us to seek for cancer therapies that follow absolute justice. In other worlds, we need to practice an approach that is more specific toward cancer cells. This could be, as we mentioned above, the use of cancer immunotherapy where cytotoxic T cells are directed towards cancer cells through genetic engineering by introducing chimeric antigen receptors (CARs). CARs should be able to recognize unique or relatively specific antigens located on the surface of cancer cells to execute them.

Cancer killing T-cells: Equipped with chimeric antigen receptors

There are three main approaches in cancer immunotherapy including immunization, use of antibodies and cellular immunotherapy. Immunization by administering a cancer vaccine prepares the patient’s own immune cells to recognize tumor cells as targets to be destroyed. The use of therapeutic antibodies specific to cancer cells recruits immune cells in the patient to abolish tumors. Cellular immunotherapy, on the other hand, uses patients’ own immune cells like the natural killer cells, cytotoxic T cells and so on. Basically, those cells could be stimulated in patients with the administration of interleukins or they could be isolated from the patients’ blood and cultured in the laboratory and following expansion and in vitro training, then transfused back to the patient to fight against cancer.

Cytotoxic T cells are unique immune cells that recognize target cells via T cell receptors. Over the past decade, scientist engineered T cell receptors and developed chimeric antigen receptors that specifically recognize target antigens. This recognition lead to signaling pathways that resulted in apoptosis of tumor cell through the production of granzymes, perforins and cytokines such as IFN-γ, and TNF-α (Figure 1). There are a number of success stories using CAR+ T cells for cancer immunotherapy used in patients. Encouraging results were obtained with CARs targeting lymphoma (by targeting CD19 antigen), coleractal Cancer (by targeting CEA antigen), and melanoma (by targeting melanocyte-specific markers MART1, MELOE-1 and gp100).

Universal chimeric antigen receptors

Two recent studies published by two different groups increased the hopes in the battle with cancer. They developed novel and universal CAR technologies that combines cell based immunotherapy and use of therapeutic monoclonal antibodies. This new approach relies on the recognition of specific molecules such as FITC and Biotin by corresponding Anti-FITC and Anti-Biotin (Avidin) CARs. The decent thing about these specific molecules is that you can attach them to any antibody, ligand, or aptamer known to target specific tumor antigens (Figure 2). One of the universal chimeric antigen receptor, for instance, uses FITC, a fluorescent molecule widely used in flow cytometric assays. Since it is easy to label antibodies, this provides wide range of antibodies to target cancer cells. In addition, scientists using this approach could target more than one tumor antigen or could use another antibody that targets different antigen even if cancer relapses. Moreover, since antibodies used to activate CAR+ T cells will degrade and their bioavailability will decrease in the body by time, there will be no need to kill injected T cells with suicide mechanisms. Once FITC labeled antibodies are stopped from being given to patients, CAR+ T cells will stop attacking cells and cease-fire since their guns (CARs) cannot recognize tumors or anything nonspecific. This approach is highly encouraging and has brought with it great hopes in the treatment of cancer.

Anarchy, spirituality, and prayer therapy

Hunger, poverty, social inequality and economical issues could be asserted as the basis of anarchy within a society. However, according to Nursi, the real basis of anarchy is spiritual weakness and poverty. Similarly, the basis for cancer could possibly be the lack of appropriate spiritual diet that may eventually make a person fall spiritually and physically weak. For example, fasting is a physical and spiritual fast prescribed in monotheistic religions which increases spirituality and has been shown to be synergistically effective in chemotherapy with cancer treatments. It has been observed and scientifically recorded that patients with strong beliefs and continuous prayers and spiritual support overcome diseases much faster than those without. This raises certain questions regarding our spiritual makeup and many other dynamics involved in being sick and getting well. So, are we getting ill because some evil spirits are manipulating our biological condition by settling in the tumors and propagating cellular anarchy? Is radiation, which leads to cellular mutations, a result of spirits that are created of “scorching fire” (The Qur’an 15:27)? Is cancer a result of such manipulations and should we seek cure for it not only through biological medicine but also through spiritual healing?

Various scientifically proven causes are known to increase the likelihood of cancer, which includes, but is not limited to, smoking, viral infections, radiation, and pollutants that lead to internal genetic faults within cells. Considering the fact that there are many cases in which patients have been reported to have recovered from their illnesses by reciting prayers, then such cases are worth examining to find out whether and to what degree non-material factors are involved as causes for our illnesses. Studying these cases may offer science new opportunities to be able to remove the present obstructions and make greater advances in the medical field by perhaps developing cancer therapies that combine prayer therapy and cancer immunotherapy using genetically engineered T cells during the treatment of patients.

Ali Fethi Toprak is a PhD candidate at University of Texas Southwestern Medical Center.

References

Döğen, Şaban. 2005. “Bediüzzaman and Anarchy.” Köprü Dergisi, No 89.

Nursi, Bediüzzaman Said. Işarâtü’l-I’caz. Şahdamar Yayınları.

Chmielewski et al. 2012. “CAR’s made it to the pancreas.” OncoImmunology 1:8, 1387–1389.

Tamada et al. 2012. “Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies.” Clin Cancer Res.

Urbanska et al. 2012. “A universal strategy for adoptive immunotherapy of cancer through use of a novel T cell antigen receptor.” Cancer Res.

Gülen. M. Fethullah. “Cinler, Hastalıklara Sebep Olabilir mi?” Retrieved from http://tr.fgulen.com/content/view/708/3/ on 12/24/12.

Bukhari, i’tikâf 8, 11, 12; Muslim, Salam, 24; Ibn Maja, Siyam 65; Abu Dawud, Sawm 79; Adab 81; Muslim and related hadith narrated by Abu Hurayrah, Bukhari 7.582.

¹ See Yücel, Salih. 2010. Prayer and Healing in Islam, NJ: Tughra Books.

Octopuses are equipped with a very powerful sensing system in addition to their sharp vision. For example, an octopus whose vision is obstructed can sense the size of objects and the distance between them. Regulation and synchronization of vision is realized with internal and external movement of the lens contrary to human beings. When it faces a threat, the octopus releases dark blue-black ink and tries to repel its enemy. Immediately after the spray, its color changes and it carefully leaves that spot. The secretion glands found in the inner face of the bladder have been programmed to secrete ink the moment the animal becomes frightened. Another function of the ink is to blunt the attacking animal’s sense of smell. Even if the animal touches the octopus at this time, it cannot recognize it.

Another striking and important ability given to the octopus is its ability to camouflage. In some situations it tries to protect itself from danger by hiding itself with this capability. If it has not been able to find a suitable place to hide, the octopus swims among the corals and, taking on the color and shape of its surroundings with the help of color cells comprised of richly colored matter (chromatophores) found under the skin, it camouflages itself perfectly.

At first glance the suckers of an octopus are no different from suction cups vacuum pressed onto smooth surfaces. However, in reality this organ is more complex than it appears to be. This organ was not created just for the purpose of sticking on objects. By means of muscles unique to it, the octopus is able to make various maneuvers.

There are approximately 200-250 suckers in two lines on each arm of the octopus. This means there are approximately 2 thousand suckers on its eight arms. There are two small chambers on each sucker. The external chamber is called a cone and the internal one is called a pot. When it sights its prey, the muscles of the external cone take the shape of the surface of the prey and completely cover it. The muscles of the internal pot structure are full of water and, disconnected from the outside world, decrease the inner pressure. This difference from the outside pressure has the effect of a vacuum. The external muscle structure enables the octopus to turn from an erect or parallel angle by decreasing the pressure difference around the object and without destroying the functional structure of the sucker.

In addition to possessing the complex muscle structures explained above, the suckers have an amazing nerve system. The chemical receptors found on the edge of the suckers (chemo-receptors) give feedback regarding the taste of the object, and the pressure and position receptors give information regarding pressure and touch. The nerves of these receptors, gathered in a node, act as a tiny brain. The chain structure extending the length of the octopus’ arm connects the suckers and nodes and synchronizes them. This structure enables the animal to lift and raise its arms without need of a command from the main brain. How this amazing task is accomplished by the brain, arm and suckers is a subject that needs investigation.

Only considering its suckers, the octopus appears before us as a creature adorned with perfect artistry and special capabilities. The characteristics of these animals being in a wise and most appropriate form is one of the clearest proofs of the blessings and benefaction of a compassionate and merciful Creator.

Canoglu is a freelance writer from Turkey with a degree on zoology.

Based on a sensible interpretation of the cosmos and events, we considered the arrival and departure of each existence in this world very normal, a process taking place in a gentle manner; this mysterious journey instilled in us profound spiritual expansion, for it was a means of reunion, each action and replacement was like being discharged of duty and freedom from the burdens of service at the end of which await the realms of divine favors hat is constantly heard, touched and smelt; we, as humans, don’t hear or feel certain things after a certain period of time. In medical terms, this process is called “adaptation to the senses.” If we have to go into a very stinky place, we intensely feel the smell at first, but after a while, we begin to feel it less. Another example can be given about those who wear glasses. They sometimes search for their glasses in different places thinking that they have lost them, even though they still wear them.

Our friend’s adaptation levelwas a little higher than the normal, but considering the disturbance of those who wear glasses would feel on their noses, it is better understood that this adaptation is a great favor of All-Powerful and All-Knowing God.

In the absence of adaptation

If we weren’t endowed with the capacity of adaptation, our brain would be busy with unnecessary information and we would be disturbed by the constant touching in our body. The cells that feel the senses are called “receptors.” There is an amazing adaptation in most parts of the cells that sense the touching in the skin. For instance, when we wear something, we feel the first touch of the garment to our body, but this feeling caused by the garment disappears afterwards. If we were to feel everything touching our skin, life would be very difficult for us. Likewise, in some patients, the adaptation to senses disappears and this makes the things harder for them. Some patients, on the other hand, develops hypersensitivity. They feel pain and suffering even by the slight touching of their garments. It is very hard to cure this illness which is called “neuropathic pain” in medicine. They feel cancer-like severe pain. Scientists are still working on the studies to stop this kind of pain.

How does adaptation occur?

Adaptation happens as a result of a different mechanism for each sense. Touching causes a liquid movement in the cytoplasm of the receptor cells. This movement is sensed by the cell and conveyed to the brain in the form of electric signals. Despite the continuation of touching, the cytoplasm movement in receptor cells is stopped after a while and no signal is sent to the brain. So, no touching is felt. But when touching stops, as a result of a liquid movement in the cytoplasm of the receptor cells, a new signal prompts the brain that “touching is over.” In short, only the beginning and the end of touching is communicated to the brain. Despite the continuation of touching between the beginning and the end, the brain (rather the “soul”) is not bothered by this redundant information. Even though, many types of receptors serve in the process of adaptation to touching, only six of them have been thoroughly studied and named. The adaptation is not the same in all receptors; fast and advanced in some of them, while in some of them it is slow and weak. For example in touching receptors of the skin (Merkel disks), the adaptation is relatively little and there is no adaptation at all in some senses such as feeling the pain. In some receptors (such as Ruffini’s corpuscles) located in dermis (bottom layer of the skin), deep organs and joint capsules, the adaptation is very little. These receptors send the weight and pressure signals required for the absence of adaptation. Weight and pressure receptors located in the joint capsule are responsible for sensing the angle degree of the joint. The brain receives information from them about the angle degree of the joints and it constantly uses it while sending orders of movement to the muscles of the skeleton. We can walk and do the other movements that require balance thanks to these perfect processes happening beyond our consciousness. If the brain didn’t know the information regarding the angle degree of the joints, some jobs that require delicate balance such as the job of construction workers wouldn’t be properly done.

Adaptation in various senses

Adaptation in seeing (accommodation): Adaptation in seeing is different from the one for touching. If we keep looking at an object, we keep seeing it. In this sense, there is no interruption in adaptation and seeing. This is another favor of God among many of His favors. If the adaptation in seeing were to be similar to the one in touching, we wouldn’t be able to do many activities that require walking, reading, sitting, standing and being in balance. All-Merciful God placed different adaptations in our eyes appropriate for the jobs that they do.

Adaptation in seeing near and far: We keep seeing an object no matter how nearer or farther we move it. Despite the change in the distance of the object, our vision doesn’t change. These processes are automatically carried out depending on the distance we look and they are operated under the framework of optical principles such as changing the shape of the eye lens and approaching of the lens to the retina or moving away from it.

Adaptation in seeing in the light and dark: Our eyes detect and adapt to the new surroundings, be it light or dark. During this adaptation process, seeing in the dark and light is made possible by adjusting the degree of vision and increasing and decreasing it one million times. The activities of the photoreceptors (in the shape of rod and cone) are carried out by an amazing knowledge and power.

Adaptation in smelling (olfaction): The smelling receptors of the nose adapt to the bad smell at a rate of 50 % in its first encounter. So, the dense bad smell felt in the first encounter disappears immediately. A minute after this encounter, the sensing of the bad smell is eliminated upon the orders coming from the brain to the nerves of smell. Garbage men or cleaners or the people working in slaughterhouse or sewerage do not get disturbed, as a favor of God, by the bad smell as much as other people do.

Adaptation in tasting: the adaptation happens one minute (at most) after the “tasting.” Yet All-Powerful and All-Knowing God created the adaptation capacity for the bitter materials very low, because most of these materials are a kind of poison for our body. Therefore when the babies unconsciously want to eat something poisonous, they take them out at once and are avoid of being poisoned.

Adaptation in temperature: The temperature receptors are intensely stimulated in sudden temperature changes. The adaptation occurs in 30 seconds or one minute as the intense of stimulation decrease. However there is no 100% adaptation, because the receptors sense both the sudden changes and constant situations. Remember, both extreme hot and cold are harmful for the body. The fact that the adaptation in this sense is limited is another favor of God.

Adaptation in hearing: When we enter a noisy environment, we are disturbed by the extreme noise. But two tiny muscles located in the middle ear contract as a manifestation of His mercy and prevent the sounds from being conveyed to the middle ear by masking all the sounds except for the ones of normal conversation. Workers in a noisy environment keep working as though they do not hear the noise at all.

Adaptation in feeling the pain: There is no adaptation in feeling the pain which is an indication of God’s mercy. If there were any adaptation to the pain, we would lose the patients before diagnosing and curing the illnesses. If a patient bothered by the gastrointestinal bleeding or appendicitis were to have an adaptation to the pain, after a few minutes he would not feel any pain before taken to the hospital and think that his illness is over and does not feel any need for a treatment. But possible inflammation of the appendix might result in the risk of death after a while.

Many of us are not aware of this perfect mechanism of adaptation. All these examples put forward the fact that the mechanisms bestowed upon our senses are very harmonious and adaptive to the working principles of our intellectual and spiritual faculties in the evaluation of various situations that we encounter in our life and they also show that humans were created as a whole. If we were deprived of such a blessing, we wouldn’t be aware of many changes that threaten our life and be bothered by the disturbing environmental conditions.

Omer Arifagaoglu is a professor of medicine. He lives in Turkey.