The cell is the structural, functional, and biological unit of all organisms. All information needed for numerous processes in a cell, including repair and division, is contained in DNA (Deoxyribonucleic acid). DNA is a huge single molecule with intriguing features. How can a single molecule have such a dominant role in preserving information essential for the continuation of life? What are the mechanisms and levels of organization during its function? What does DNA mean for a single cell or for a human being? It’s impossible to answer these great questions in a single article; however, understanding the ways DNA exerts its role, DNA’s impact on multiple levels ranging from a single cell to an organism, and coordination between various levels, can potentially open up new frontiers in our mind and in our perception of life.

“Double helix” architecture of DNA DNA has an elegant structure that forms the basis for all of its functions. DNA is a repeating structure of nucleotides. Each nucleotide is formed of a phosphate group, 5-carbon sugar (deoxyribose) and a nitrogen-containing base attached to the sugar from outside to inside (See Figure 1a for a schematic view of DNA). There are four types of nucleotides in DNA, differing only in bases. We can consider bases as the identity of nucleotides. These four nucleotides are shown with letters A (adenine), T (thymine), G (guanine) and C (cytosine). Thousands of nucleotides bound with sugar-phosphate covalent bonds come together to form long strings. The sugar-phosphate backbone can be imagined as the steelwork of a skyscraper. The nice thing about nucleotides is their specific match to each other in double helix. A forms a base pair with only T, and G forms a base pair with only C. These pairs are bound to each other with hydrogen bonds. This feature is the key that makes DNA a double ladder. Two strings of nucleotides form a double helix by selective interactions of As with Ts, and Gs with Cs (See Figure 1b for 3-D structure of DNA). In DNA structure, hydrophobic bases tend to stay inside of double helix and hydrophilic sugar-phosphates stay outside interacting with water in nucleus. This feature helps DNA to form a double ladder. The length of the sugar-phosphate backbone is more than the bases. To compensate for the length difference, the sugar-phosphate backbone wraps around the bases inside, as a road wraps around a mountain to climb to the top. This simple difference is the main reason for DNA to form a helix.

The double-stranded nature of DNA with specific base pairing is one of its key features as genetic material. DNA is replicated using one strand as a template. Replication machinery reads one strand of DNA and builds the second strand by putting As against Ts and Gs against Cs. If a mutation occurs in one strand, it can be repaired using the second strand. This system is like photocopying DNA from itself instead of building it from scratch every time. That is why specific base pairing of nucleotides in the double helix makes it possible to replicate DNA through generations, protecting its integrity and information content. The code of DNA, an alphabet with four letters DNA contains the information to produce nano-sized cellular machineries called proteins. We mentioned that there are four types of nucleotides. Nucleotides are like letters in DNA, three of them are code for one amino acid of protein. We can make it more understandable by giving an example: “ATG-GCC-CTG-TGG-ATG” as a nucleotide sequence of DNA corresponds to the first five amino acids of a protein called insulin (a hormone regulating blood glucose level that is important in diabetes) and amino acid sequence is methionine-alanine-leucine-tryptophan-methionine. The code is so sensitive that even a single mistake in the sequence of DNA can cause serious diseases in humans such as sickle-cell disease or cystic fibrosis. With all these nucleotides, DNA can be thought of as a book containing amino acid sequence information for thousands of proteins (about 30,000 in humans). The amount of information contained in DNA is incredible: a typical human cell contains 2 meters of DNA that is tightly packed by proteins in the nucleus. If we tried to write the information from DNA into books, the book would contain over one billion words and 1,500,000 pages. DNA-protein interdependency and the cell as a micro-factory DNA can be thought of as an instruction manual that stores information for proteins and RNAs. Proteins, as molecular machines, perform particular tasks such as energy production and synthesis of DNA and RNA (See Figure 2 for the structure of proteins). Certain proteins read the information on DNA and make a transient copy of certain regions of DNA. These copies are called messenger-RNAs (mRNAs) and mRNAs are transported from nucleus to cytoplasm (See Figure 3 for representation of mRNA production from DNA by proteins). In cytoplasm, the information on mRNAs is read by protein complexes called ribosome. Ribosomes produce new proteins processing the data from mRNAs. This information flow from DNA to proteins is called central dogma in molecular biology (Figure 4). The data that is encoded in DNA can be read, translated, and put into the form of product only by proteins. We can conclude that for a protein to be produced, DNA is essential; for DNA regions to be read into proteins, proteins are essential. So, there is interdependency between proteins and DNA. Proteins without DNA have no future and no ability to regenerate and DNA without proteins is just like an instruction and manufacture manual of a computer without the user and computer itself. We can imagine the cell as a sophisticated factory, and proteins as the machines of the factory. DNA includes the instructions for the factory to be rebuilt and for itself to be rewritten for every new factory. It has instructions on how to build every machine in the factory. It has also codes for when and how much of these machines should be produced (we will discuss more about these codes on DNA in the next section). On the other hand, the timing and control of all these productions also depend on machines in the factory. Some of these machineries read and decode the instruction manual, some of them produce new machines by reading the decoded copies of the instruction manual, some of them act as sensors for the signals, some of them transmit signals to other machines, some of them produce signals by measuring the levels of materials in the factory, some of them function in communication with other factories, and so on. As we can see, DNA and proteins are meaningful for life only when they are together in the excellent cell context. This is a perfect example of the principle that the whole is bigger than the sum of its parts, because each element of the cell system has limited potential, until it comes together with the others to blossom into life.

The famous term “Gene” We can think of genes as functional units of DNA. A gene has the information content for at least one protein. Humans have about 20,500 genes that are read by protein machineries to produce proteins. Special proteins read the information on genes and make a transient copy of these certain regions of DNA. The process of making a copy of a gene as an mRNA is called transcription.

Genes don’t only store information; they have an intrinsic architecture of design to coordinate transcription utilizing three main components: promoter, coding region, and terminator. The promoter is the gene region that signals for the start of transcription. Protein machineries bind to the promoter and activate transcription. The coding region has the information for the amino acid sequence of the protein. The terminator region gives the stop signal for transcription. There are different functional regions on DNA located between separate genes such as enhancer regions that are platforms for binding regulatory proteins to tune the transcription.

The coding region of genes has multiple reading blocks for amino acid sequences and these reading blocks are called as exons. For some genes, different combinations of exons can be put together to give rise to different proteins. This mechanism allows one gene to be able to produce multiple proteins, increasing the efficiency of genetic material. A similar mechanism is used to produce antibodies (proteins recognizing foreign antigens) by the immune system. Different regional genes come together by a mechanism of DNA rearrangement (V(D)J recombination) and their differential combinations form many different antibodies. For example, a part of the antibody that is called a heavy chain is produced by a DNA region containing 65 variable (V) genes plus 27 diversity (D) genes and 6 joining (J) genes (5, 6). This produces a combination of 65 V genes x 27 D genes x 6 J genes = 10,530 heavy chains. There is a similar mechanism of rearrangement for light chain and variable region of antibodies, which result in millions of different antibodies for host antigens. A single example in the immune system shows us that DNA not only has a decent design for the coding system, but it also has ingenious and creative mechanisms to maximize its potential.

Gene expression is orchestrated during development and formation of organs The human body which consists of more than 1013 (ten trillion) cells is generated from a single cell called the zygote (see Figure 5). This tells us that, in a single cell, all the information and instructions to build and coordinate the systems of human body is encoded. Different tissues and organs including muscles, nerve cells, connective tissue, and eyes are fruits of one single cell. They all contain the same genetic information. Then what makes them different?

Promoters, enhancers, and repressors located in and nearby genes are important in spatial and temporal control of gene expression in different cell types of the body. Each cell type in our organs expresses a different subset of genes; this is what gives a cell its identity. For example, in muscles, myosin is expressed and in the eye’s retina, rhodopsin is expressed. Myosin functions in contraction and rhodopsin functions in vision. What determines the expression of rhodopsin in the eye but not in a muscle? The determination process occurs during development by programmed interactions of specific proteins called transcription factors, and restricted regions of DNA including promoters and enhancers. During development, certain regulatory proteins in a specific cell type, bind to DNA regions of only some genes (for example, in future retinal cells of the eye, rhodopsin gene would be activated but not myosin) and this predetermination orchestrates differential expression of genes to give rise to hundreds of different types of cells.

Different layers of complexity and organization related to DNA

There are different layers of function for DNA—each subtitle of this article tries to focus on a certain layer of function. DNA as a molecule has a double helix structure and is replicated through generations to preserve genetic information. It stores genetic information and has a four-letter alphabet for the expression of proteins. In the second layer, DNA has an informational unit called gene and thousands of genes are encoded in DNA to contain information for proteins. Each gene is controlled individually by making use of promoters and enhancers. In the third layer, all processes in the cell micro-factory as an entity are performed through interactions of DNA and proteins with each other and among themselves. Proteins read DNA code and work as cellular nano-machineries. In another layer, temporal and spatial expression of genes on DNA are orchestrated and different subsets of genes give rise to different cell types and organs. Organs communicate with each other to function properly and keep the balance and homeostasis of the body. The information stored in DNA not only coordinates highly sophisticated processes of a single cell, it simultaneously projects the whole body system of a human being, which is billions times bigger than a single cell.

DNA functions in all these different layers and keeps a great harmony in coordination between various layers of function. After grasping this complexity, organization and communication from a single molecule, to proteins, to a single cell, to tissues and organs, and to a human being by utilization of DNA, should not we ask ourselves, “can these elements come into existence by random forces and collisions?

References

1. Calladine, C. R. et al. 2004. Understanding DNA: The Molecule and How It Works, Academic Press

2. http://www.genome.gov

3. Li A, Rue M, Zhou J, et al. 2004. “Utilization of Ig heavy chain variable, diversity, and joining gene segments in children with B-lineage acute lymphoblastic leukemia: implications for the mechanisms of VDJ recombination and for pathogenesis.” Blood 103 June (12): 4602–9.

Finally, I have come to say goodbye to you. As you probably know, there is a saying “Leave the best till last.” I am the greatest of all the organs and systems that have described themselves to you so far. I am an integrative system that forms a chain between every organ in your body. Just as your veins are spread out to carry nutrients and oxygen to every part of your body, I also embrace your entire system like a network, without leaving the tiniest space; I am informed of everything that goes on inside your body. Even if a tiny insect settles on your arm, you sense it immediately. I make you aware of a tiny drop of sweat on your body. I induce pain in suitable measures to inform you of any illnesses in your inner organs. In fact, I not only inform you, I also warn you to seek help.

However, it is hard for me to describe myself. When you hear the words “nervous system,” what comes to mind is a cluster of cells called neurons. But this is a great mass of cells, and we should always remember that we are referring to the most complex matter in all of creation. The very important main nervous systems, which are very close to one another, are the huge masses positioned beneath the skull, the extensions of my system and secondary nervous system; this latter is spread out through various regions of the body. It would take up too much of your time to describe each region and branch of my system individually to you each month, but in this way I could prove what a perfect and incredible duty each of them performs within your body. However, I will try to explain the subject briefly to avoid boring you. Nevertheless, please forgive me if I ramble on too much; we are describing the most excellent organ created by God so it is inevitable that there will be some complicated matters that need clarification.

Instead of allowing each of my sections to describe themselves to you individually, I will speak on their behalf as the “brain.” It may be easier for you to understand the system if we divide it into two. One of them is me and the nervous system which I lead; we can briefly describe this as the thalamus, hypothalamus, cerebellum, the medulla, and the spine. The other part is the peripheral nervous system, which emerges from the central nervous system and is distributed, rather like fiber optic telephone cables, throughout the entire body. In addition to me, the brain, and my two large cerebral hemispheres, there is another smaller section, which is known as the brain stem. The brain and its cerebral hemispheres and the sections of the brain stem which are protected beneath the skull (the cerebellum, medulla, thalamus, and hypothalamus) are very important. The spinal cord, which is also a part of the central nervous system, however is not in the skull, but positioned within the vertebrae that constitute the spine. Due to its connection with the central nervous system, any damage to the spinal cord can endanger life.

Although damage to regions of the body where the nerves are distributed from the central nervous system may cause paralysis, or functional disorder for the specific organ, such an incident is not life threatening.

If you recall, when the heart and circulation system described themselves they boasted – indeed the veins also seemed to brag a bit when they stated that they measured 75,000 miles (long enough to go around the world almost three times). But the nerves are approximately 477,000 miles, long enough to stretch from the earth to the moon, and back again… the nerves which are distributed throughout the various parts of your body measure 250,000 miles, and the total length of the central nervous system is 228,000 miles. Almost 200,000 signals pass through just one cell at a time, which means that every moment thousands of signals pass through millions of my cells all throughout your body, and flow from the central nervous system to the whole body and then back to the central nervous system. There are about 30 billion cells in my system. 10 billion of these cells are in the cortex, 10 billion in the cerebellum, and the remainder forms the structure of the nerves and other sections. As a comparison, a fly’s brain contains 100 thousand cells, and a rat’s brain has 10 million cells. The total number of connections and contact points (synapses) that my 30 billion cells use to send and receive signals is 100 trillion. The number of combinations that these connections can establish to send signals to one another is greater than the number of atoms in the universe. At the beginning of a thinking process, the number of cells activated is between 10 and 100 million, and according to the depth and intensity of the activity, these figures can increase to astounding numbers. Every second 4 billion signals are exchanged between the left and right hemispheres. When you were an embryo, just a few weeks old, I consisted of 92% water. When you were first born, the ratio of water was 90%. And when you were fully developed, the water ratio remains at 77%. Peter! Can you imagine, a heap of mass consisting of 77% water, the remainder made up of various element. Our Lord, the bearer of eternal power places me in you, in the head of the most honorable creation, and with me you form civilizations; you invent and discover. And even more important, with my mediation you have the ability to contemplate and reach your Creator. What we are learning about here is how with me you are able to recognize the wisdom of the entire universe. The electric signals of the various sense organs, such as the eyes, ears, nose, tongue and skin, all of which have previously described themselves, are transmitted by the receptive cells on various wavelengths; these are then conveyed to you in the form of sight, noise, smell and taste. In fact I am inducing you to write these words at this very moment. The evaluation of everything you do passes through me, but you are not even aware of it. When you walk, eat, talk, speak or sleep, the information I receive from every part of your body is reviewed and responded to in a suitable manner. Dear Peter! Could a single nucleus of a single one of my cells possibly position itself alone?

The Lord has created me so magnificently that you are still only aware of a very few of my mysteries. Each of the sections that I mentioned above has a distinct and important vital function. On their behalf, I will briefly explain their duties: The cerebellum is the nerve center from which the harmony of balance and muscle movement is controlled. As this section of me has no sense of perception, it is impossible to voluntarily change the functions of this region. The pyramid shaped medulla oblongata, which connects the spinal cord to the midbrain and the pons; the latter constitutes the other end of the brainstem through a hole in the back of the skull in the form of the spinal cord and enters into the vertebral column. Here, there are many nerve centers which regulate autonomic nervous system activity, such as the heart rate, breathing, and digestion process. This is also the center from which the reflexes are controlled, the body’s inner environment is regulated, and this center, working with the cerebellum also controls movement and coordinates signals received from the nerves of inner organs. Moreover, activities such as excitement and sleep are also controlled here in collaboration with the thalamus.

The thalamus lies between the brainstem and the hemispheres of the brain, performing a function rather like a junction or relay station. This section gathers all the signals sent by the sense receptors, except for those from the olfactory (smell) receptors, and conveys these signals to the cortex reflecting the information; there is also a role played in consciously identifying sensations such as pain, touch and noise. There is also a role played in the sensory changes that occur with the perception of senses in our consciousness and awareness, as well as in the regulation of sleep and paying attention. The hypothalamus, which is located below the thalamus, is an important center that controls sexual senses; the sensations of pain, pleasure, hunger, and thirst, as well as blood pressure, temperature and other functions of the inner organs. It also performs the important duty of regulating hormone release. The nerve fibers that enter this center, which is the location of a very complex network of nerves coming from the olfactory bulb, thalamus, and the frontal lobe, reach the autonomic nervous system, the reticular formation in the stem section, and the posterior lobe behind the pituitary gland (hypophysis). The pituitary gland, one of the most important systems that earlier described itself in the endocrine system, produces hormones that stimulate secretion in the anterior section, as well as the oxytocin and antidiuretic hormones which are stored and released from the posterior pituitary.

On the base of the deep grove that separates the two hemispheres of the large brain there is a callus-like body; this is a bundle of axon (nerves) called the corpus callosum which connects the two hemispheres. Because the nerve fibers cross and change direction in the medulla, the left side of the brain controls your right side, and the right controls your left. Although my two hemispheres may look like a reflection of one another, there are some variations in their duties; for example, the left hemisphere controls speech, but the section which controls the perception of location is in the right hemisphere. Whilst you use the left hemisphere for duties that must be performed in a specific order (activities such as adding and subtracting or buttoning a shirt), you use the right hemisphere in thinking with images (for example, mapping the route from your home to the market). If the callus substance that connects my two hemispheres did not exist, there would be no communication between the two, therefore, you could read the word “fish,” but you would not be able to picture the image of a fish in your mind without the right hemisphere to achieve this.

The brain, the grey-colored mass of folds and grooves that covers the top of my anatomic hemispheres, the region where the main stems of my cells are found, is called the cortex or grey matter; the lighter colored matter that lies beneath this, the region where the axons (stems of neurons) are found, is called the white matter. My cortex region, which is composed of six layers of cells, is the center where the sensory signals are received and analyzed and where voluntary muscle movement is controlled, while also being the center of activities, such as learning, reasoning, and remembering. My two hemispheres, the focal point of conscious activity and thought that forms the large brain, constitute 85% of the whole brain. When you were first born I weighed 400 grams, but I grew very quickly, and by the time you were a year old I weighed 800 grams. When you were four years old, I weighed 1,200 gr. However, my growth began to slow down after the age of seven, and when you reach twenty, I will weigh approximately 1,379–1,434 grams. When you begin to pass your first youth, my weight begins to decrease every year by 1 gram, so when you reach seventy-five, I would have shrunk in comparison to when you were twenty. The reason for this decrease in weight is that approximate 50,000 neurons die, or cease to function daily, after you reach the age of twenty. The body cells of the cartilage, bone, skin, ligaments and the liver divide, regenerate and increase in number; however, the nerve cells that are part of me continue to increase until they reach the figure set out for you when you were formed in your mother’s womb; they then lose the ability to segregate. So if there is any damage, relative functions fail because the cells in that region have died. Then the question arises: As there is no increase in the numbers of cells, how does the weight continue to increase until the age of twenty? Well, there is not an increase in the numbers of cells; rather, there is an increase in the number and growth of connections between the cells and this is how my weight increases. Of course, nutrients are added to build and stimulate these connections. Subsequently, with age these connections begin to decrease. With ever experience you have, all the things that you learn or see during your youth these connections increase, and in turn this increases my capacity for thought and reasoning. If you continue to activate your brain by reading, writing and other social activities in old age, these connections continue to increase. Even if there is a decrease in my cells, you are able to continue your usual activities without losing any functions of the brain. But as soon as you say that is enough, it is time for a rest, my cells begin to withdraw their connections immediately, and in time you will certainly see the difference in my capacity. If the cells in my central nervous system are injured or damaged, they cannot repair themselves. However, if the cell bodies of my cells in the peripheral nervous system are not damaged the stems are repairable.

Thanks to this special feature if a severed arm, leg or finger can be carefully replaced with microsurgery, the nerves can repair themselves, and the limb will continue its normal functions. The visible cause of this characteristic is found in the nerves of the arms and legs, but not in the brain or spine, is the casing that surrounds this bundle of nerves that transmits signals for the cells to grow. Even with the greatest of techniques, no surgeon could sew the severed nerve fibers. However, thanks to the nerve casing that holds these fibers together (like the plastic that covers the electric cable, consisting of thin wires) the severed limb can be replanted. Then with guidance from this outer casing, each of the hundreds of fibers found inside grow 1 mm every day, and in a period of between 1 month and a year, they will begin to function again.

Irfan Yilmaz is a professor of biology at Dokuz Eylul University, Izmir. 

Decisions within the cell: mathematical and algorithmic character

In order to enable Escherichia coli bacteria to use lactose (disaccharide), the genetic information of the enzymes that have role in transporting the lactose into the cell and converting it into glucose is coded in the bacteria’s genome. The binding and decoding structure which enables the genes to be transcribed at the right time in the appropriate amount is called the operon. The operons are model mechanisms which work on the synthesis or destruction of every chemical molecule (metabolite). One of these, lactose operon, is a good example that demonstrates how the decoding information contained in DNA is regulated and controlled in the bacteria. E. Coli is equipped with a system that distinguishes lactose and glucose when they are combined and this system functions perfectly. Primarily, all of the existing glucose is consumed before the start of the production of those enzymes that splits lactose into glucose and galactose. It has been discovered that this operation in the bacteria is followed by an interaction between DNA sequences located on the upper part of the lactose gene and various molecules. The DNA sequences on the upper part of the gene are the signals that format DNA for transcription. These signals cause the decoding of the genes that interact with the transcription factors. While some of the signals in the relevant region of the genes are common in most genes, some others are specific.

The most basic interaction system of the genome-proteome (all proteins in cell) is the suppression of the lactose operon that is observed in E. Coli. This process depends on DNA-protein interactions which are based on a mutual relationship and it requires the existence of repeated DNA sequences. Tetramer lac1 protein control the lac operon binds to four repeating binding regions on the DNA. Since one dimer can be connected to one operator sequence, two dimers are connected to two operator region units, and as a result the result is a loop formation in the DNA structure. Consequently, because of the access of RNA polymerase to the promoter region, the pre-coding process of genes is hindered. If the hindering protein is in the form of a monomer, the operator displays a weak interaction with half of the sequence. In the dimer form there is a stable binding. For this reason, many procedures in the cell occur by working together and making a union of molecules. Since the loop shape of DNA stabilizes the structure, it prevents the RNA polymerase from being connected to the promoter region. In order to eliminate the blockage on the lac operon, the mutual relationship must be prevented by stimulatory molecules, such as lactose.

There is metabolic information in cells that measure and control the physiological condition. The sequences on the regulatory region of the lactose operator and the data concerning the physiological condition of the lactose and glucose metabolisms are analyzed in the cell which perceives the presence and the amount of glucose through the changes in the system that transports the glucose into the cell. The molecule that announces the presence of glucose in E.coli is cyclic-AMP and concentration of this molecule in the cell is inversely proportional to glucose. The level of this signal affects both the coding and regulation of genomic information. The protein that transports glucose into the cell contains a phosphate group; as it transports glucose into the cell, this carrier protein phosphorylates the glucose molecule thereby loosing its phosphate group. As a result, the proportion phosphorylated transport protein and those without phosphate provides information about the glucose level in the cell. The phosphorylated form of the carrier protein activates the adenosine cyclase enzyme. Through this enzyme, ATP is converted into cyclic-AMP. The cyclic-AMP level increases in the cell. Consequently, the situation that concerns the increasing concentration of the phosphorylated transfer protein and the cyclic-AMP is interpreted as non-existence of glucose in the cell. The CRP protein that binds to regulatory region of the lactose can only bind to this region in the presence of cyclic-AMP. The cyclic-AMP-CRP complex which is tied to the promoter region of the lactose gene speeds up the transcription of the lactose operon. Transcription rarely happens when there is no lactose. This is because the lactose repressor protein lacI, hinders the RNA polymerase reaching the lactose promoter region by binding to the operator of regulating region. The cell can sense the existence of lactose in a circuitous manner. Low levels of coded Permease enzyme on the lacY region transfer some lactose into the cell. The coded beta galactosidase on the lac Z region alters them into a sugar called allolactose. The allolactose is bound to the lacI repressor protein and changes its conformation. The allolactose –lacI repressor complex can not bind to the operator region. The promoter region, called LacP, of Lactose operon is set free for transcription. In fact, every one of these molecular interactions is an incident of information being transferred. All these incidents demonstrate that an algorithm (If there is no glucose and only lactose exists, then transcribe the lacZYA enzyme) that is able to distinguish the difference between two sugars exists in bacteria cells and that it functions perfectly.

In short, the signal transfer in lactose operon occurs with the activation of chemical molecules that represent the experimental data pertaining to the physiological environment of the cells. For example, the levels of cyclic-AMP, allolactose and protein phosphorylation indicate the existence of glucose and lactose. The regulating network system, on the other hand, combines many aspects of cell activity (transport, enzymology, energy metabolism) in order to make the transcription decision. Briefly, it is impossible to show that arranging the order of the genome in any cell occurs independently from physiological or biochemical processes.

The principle of “using combinations in the arrangement of specific binding regions” is commonly used in metabolic signal networks that control cell physiology and the differentiation of cell (morphogenesis) that are oriented towards tissue formation. Such an interaction takes place on these network paths between proteins and DNA sequences to ensure that the cell is allowed to process molecular information and to calculate whether it will transcribe a specific genetic sequence. The common binding regions on DNA have vital roles in the coordinated control of various genetic loci, and it is then that the decoding of genes in a harmonious (symphonic) manner becomes possible. Various combinations of these regions are also used in making more complex decisions. As an example, protein-binding regions that are involved in the lowest level of genomic indicators have a role in decoding genes. The proteins that bind to these DNA sequences can become active when they form a group that has an interaction with more than one protein molecule. For instance, each one of the lacO and CRP regions on the lactose operon shows a palindromic sequence structure (the DNA sequence remains the same when the sequence is read from either end). Similarly, the lacP region has two lower regions that are appropriate for the binding of RNA polymerase and are separated from each other by a 16–17 base pair. In all living beings, the proteins and DNA sequences interact with each other. For example, the LacI repressor, which is in charge of controlling the lactose operon,has separate regions for not only binding the DNA region, but also for creating protein-protein binding as well as the binding of allolactose stimulator. The unique combinations of this region on the genome sequence result in a unique protein synthesis.

The genetic engineering procedures in cells

Some of the genetic engineering procedures that take place in the cells are as follows: Recombination systems (mutual material exchange) that are observed in homologous chromosomes (the chromosome pair derived from each parent), recombination specific to a particular region; separation of DNA sequences specific to those regions (fusion of gene pieces, VDJ recombination of genes as appointed in the immune system); the existence of systems that combine end points in non-homologous chromosomes (the binding of broken DNA parts, the formation of new genetic fusion, the formation of sequences that are open to hyper mutations); DNA transposons (DNA sequences that can insert themselves into different DNA sequences or can copy themselves there and leave a copy); the RNA sector that can control the transcription and signals that are responsible for the maturing transcription; the signal sequences that cause the rearrangement of neighboring DNA sequences (such as amplification, deletion, and inversion); and finally, controlling the transcription with micro RNAs.

None of the above phenomena which cause in-cell changes are random. Each of the genetic engineering functions is planned in a way that makes specific changes and arrangements. In the processes of insertion, i.e. when a specific amount of DNA is added to a different region of the genome, or deletion, i.e. when a specific amount of DNA is severed, there should be arranging, cutting and coding sequences that will bind the cut part to its new place in an appropriate way. On the genome, special regions that are suitable to mutation are created in order to produce variety and to respond to adaptation. When all these molecular engineering functions are thoroughly analyzed, it can be seen that even the point mutations, which up until now were thought to have happened by chance, are not coincidence; rather, they occur through the divinely designed genetic engineering functions. Most of the mutations that are thought to occur by chance in the cell have been removed by the repair systems and fault correction functions in the cell. Thus, the changeability and variety in DNA sequences are shaped by the power and will of God the Almighty according to a planned, programmed genetic schedule.

The R&D department of the genome

Depending on the stimulation received, God-given genetic engineering functions are arranged in the cells and a decision is made about which parts of the genome should be changed. Some of the changes inside the cell appear on a large scale. Inside the genome, different and far removed regions can be rearranged. The changes are related to one another and are in no way disconnected. One mechanism can produce more than one change. The reconstruction of changes in some organisms is a part of the normal life cycle. In the Cornelius protozoan, the embryonic genome is regularly decomposed to a thousand slices. Then, through processing and rearranging in the cells, a functional genome with a distinct system structure is created.

While the genome is reshaped, there is the production of new different sequences rather than the sequences that they regulate and which have the code for the continuity of existing phenotype features. The organization of the genome along the system base emerges with the functions of the genetic molecules, such as cut-paste-rearrange. For example, in immune system cells, there is a planned disposition to mutation and the specific antibodies are rearranged to recognize an infinite number of different antigens. The life cycles of lymphocytes demonstrates both the control of the DNA rearrangement improvements and the specificity of mutations. It is estimated that the new sequences which do not change the existing structure operate like a research center for the genome.

The God-given genetic engineering systems imposed in the cells, when analyzed from the perspective of the population, are molecular mechanisms that carry out basic changes to ensure adaptation. The duty of reconstructing the genome during adaptation has been assigned to the divine genetic engineering functions imposed in the cell. The divine genetic engineering tools and mechanisms, which are placed in the cell with active nucleic acid elements that carry information, change the genome in parallel to the changes in both the inner and outer environment; this change occurs not only on one point of the genome, but rather on every point of genome. The functions of the DNA elements, which allow for the exchange of genetic information (both horizontally and vertically, in species and between species, between types and classes), are arranged by domestic cell signal transfer and data process networks. The signal network systems that are in charge of rearranging and controlling in-cell procedures not only control when the genome is rearranged, at the same time it decides where these rearrangements take place inside the genome. The selection of the target is planned, it is not random. For instance, R1 and R2 retrotransposons which are established in the DNA region that codes 28S ribosomal RNA have specific recognition regions and the information of endonuclease cutting DNA region on specific points that it had settled down. Eukaryotic cells have more complex decision making systems. The cells continuously create responses in response to DNA damage, cell physiology and outer-cell reproduction factors. One of the critical questions and answers is whether the damage will be repaired or whether programmed death will take place. If the cell avoids giving an answer, then genetic indecisiveness appears and abnormal cell reproduction, i.e., cancer, begins. From this perspective, cancer is a result of pathology in the signal and information process in the cell. The changes in gene expression without any changes in the DNA sequence (epigenetic) as well as the divine genetic engineering functions are clear proof demonstrating that every single action in the cell occurs with a certain aim that is based on knowledge and calculations.

Hamza Aydin holds a PhD in biology.

References

• Shapiro J. A.(2001). “Genome Formatting for Computation and Function: Genome Organization and Reorganization in Evolution: Formatting for Computation and Function.” Presented at the “Contextualizing the Genome” symposium, Ghent University, Belgium, November 25–28, 2001 (Ann. N.Y. Acad. Sci., in press).
• –. (2005). “A 21st century view of evolution: genome system architecture, repetitive DNA, and natural genetic engineering.” Gene 345 (2005) pp. 91–100.
• Shapiro J. A. and Sternberg R V (2005). “Why repetitive DNA is essential to genome function.” Biol. Rev. (2005), 80, pp. 1–24. Cambridge Philosophical Society. DOI: 10.1017/S1464793104006657.

Roughly speaking, the bulk of Central Eurasia consists of Central Asia and the Caucasus but also stretches to such regions as Turkey, the Turkic/Muslim regions of southern Russia, northern Afghanistan, southern Siberia, Tibet and Mongolia.[1] Largely due to Turkic influence, shaped historically by a tolerant understanding of co-existence as enjoined in Islam, this region has won prestige internationally for its peaceful efforts in this diverse geographical area.

Such leading U.S. universities as Harvard University, the University of Wisconsin at Madison, the University of California in Los Angeles, and the University of Indiana in Bloomington offer graduate courses on Central Eurasian studies and languages. The notion of a “clash of civilizations” promoted by Huntington[2] in the era of globalization has never been accepted by many people throughout Central Eurasia in their rich historical experiences of living in “mosaic societies.”

Pluralistic Islam at the heart of Eurasia

Unfortunately, for last couple of decades the experience of the diverse pluralistic Islam of Central Eurasia has been obscured by the political trends of Islam in the Middle East. The latter, rather than the former, has become the focus of most academic scholars of social sciences and humanities and media. Historically, while Turkey formed the western boundary of the Muslim world, Central Eurasia has largely represented the northern and north-eastern boundaries of the classical Islamic world. Islam in Central Eurasia emerged mainly through remarkable Sufi masters like Ahmet Yassavi, Korkyt Ata, Mevlana Rumi, and Baba Tukes. The merchant caravanserais of the Silk Road that traversed vast areas between the Middle East and China came into existence through peaceful means, and new Muslims in this area were very tolerant toward the many religions and cultures of their neighbors. Although the revelation of the Qur’an started in Arabia, most of its scholarly interpretations and the hadith compilations were compiled in Central Asia.[3] The greatest contributions to almost all areas of religious and positive sciences, engineering, art and culture were witnessed in this part of the world between the ninth and fourteenth centuries ce. The works of such outstanding intellectual figures as Ibn Sina (Avicenna), Al-Farabi (Alfarabius), Al-Khwarizmi still benefit

people all over the world. The largest library in the world in the thirteenth century ce was in Otrar (a city in present-day southern Kazakhstan), which was later totally demolished by Genghis Khan during Mongol invasion.

In the period between the seventh and thirteenth centuriesce, the Muslim world was ruled predominantly by Arab caliphs of the Umayyad and Abbasid dynasties. However, starting from the twelfth century up until the beginning of the twentieth century, Muslims of Central Eurasia of predominantly Turkic origin became the foremost rulers of the Muslim nations. Among them were the famous states administered by the Seljuks in Central Asia, the Golden Horde in Russia, the Baburides on the Indian subcontinent, the Mamluks in Egypt, and the Ottomans in Eastern Europe, North Africa and the Middle East.

The Golden Horde’s legacy of tolerance toward Christian, Jewish and Buddhist communities laid the foundation for the flourishing of Moscow and the Russian

Empire, which became heir to the Golden Horde’s legacy.[4] Saray, which was the capital of the Golden Horde from thirteen to fifteen centuries, and which was located very close to the border of modern-day southern Russia and western Kazakhstan, became a center of intercontinental diplomacy as envoys and ambassadors representing princes and popes sought audiences with the Muslim khans of the Golden Horde.[5]

Dialogue between world religions in Central Eurasia in the modern secular context

After more than two hundred years of Czarist rule, the ex-Soviet Central Asian republic of Kazakhstan, being one of the most diverse countries in the world, the home of 120 ethnic groups and many world religious communities for the last seventeen years became the active initiator of peace, dialogue, integration and reconciliation initiatives across not just the Eurasian states of the former Soviet Union, but also the larger international community. After independence, to ease tension among superpowers Kazakhstan’s government decided unilaterally to dismantle the huge nuclear arsenal left as the Soviet legacy of the cold war. Following the breakup of the USSR, Kazakhstan’s President Nursultan Nazarbaev’s proposal to form a “Eurasian Union” was praised by many leaders across Russia and the ex-Soviet republics. The late pope John Paul II met Nazarbaev in Astana on September 11, 2001.

Muslim–Jewish dialogue in Central Eurasia

In 2002 Kazakhstan served as the facilitator of Islamic– Jewish dialogue in Eurasia, an event which took place in the new capital, Astana. At the conference, thirty rabbis from various countries noted that the only way forward in the relationship between Muslims and Jews is through constructive dialogue. They also expressed their wish to see Kazakhstan as a center of Muslim–Jewish dialogue.[6] The fact that the headquarters of the Euro-Asian Jewish Congress (EAJC) was placed in Almaty, the largest city in Muslim Kazakhstan, at a time when there is growing instability in the Middle East, is a sign of the huge potential of the mutual trust between Muslim and Jewish communities in Eurasia.[7] Alexander Mashkevich, the head of the EAJC, considers Kazakhstan a unique example of cooperation and peaceful coexistence between various peoples and religions. He also noted that the largest synagogue in Central Asia, which was opened in Astana, best characterizes Muslim Kazakhstan as the land of inter-ethnic peace and inter-confessional harmony.The latest phase of this dialogue at the First International Conference of Peace and Accord was held in Almaty the previous year. Presidents of the leading Jewish organizations of the United States, leaders and plenipotentiaries of the states of Central Asia, Azerbaijan and Turkey, and members of the leadership and the Council of Rabbis and Central Asian Muslim leaders condemned terrorism and declared that there are no antagonistic contradictions between Judaism and Islam.

Dialogue between world and traditional religions at the heart of Eurasia

At a time when some dark forces are trying to bring about a clash of world religions and civilizations, Central Eurasia offered an unprecedented challenge to these dangerous trends by initiating a series of high profile civic activities bringing together members of the clergy of world and traditional religions in the heartof Eurasia in Kazakhstan’s capital Astana in 2003 and 2006.[8] A unique role model for intercultural communication and dialogue, Kazakhstan, with a number of other countries of Central Eurasia, showed the whole world that traditional values can be reconciled with liberal norms in the formation of a successful, peace-loving, civil, mosaic society. Leading Turkish Islamic scholar Fethullah Gulen, active promoter of interfaith and intercultural dialogue, valued this significant interfaith event in Eurasia highly and said, “The only way for humankind to solve its problems is by way of dialogue: meeting, learning and talking to each other…With all my heart I state that all these initiatives done out of pure intentions will serve to establish peace and stability in the region, to improve relationships among nations and also to build lasting peace on the whole planet.”[9]

Dialogue Eurasia: “DA”

A number of Turkish people are working to pave the way for dialogue in the Eurasia region.[10], [11] Diyalog Avrasya (Dialogue Eurasia), a publication of the Dialogue Eurasia Platform, has been the voice of common sense in seventeen countries, from Moldavia to Mongolia, since its founding in 2000. A bilingual quarterly published in Turkish and Russian, DA adopts an approach to conflict with reconciliation, using the slogan, “Dialogue starts with ‘DA’” (“Da” in Russian means “yes” in English). DA representatives recently gathered in Istanbul and discussed the latest developments in the Eurasia region. DA stressed that its ideology is knowledge and love, and that convergence, compromise and understanding constitute the backbone of their policy. Renowned Kyrgyz writer Chingiz Aytmatov, who passed away recently, also served on the journal’s advisory board; he described DA as “the business card of Eurasia.” Garnering great interest in the countries where it is published, DA also brings together Eurasia’s famous writers, intellectuals and civil society volunteers. In addition, opinions and essays of leading politicians frequently appear in the journal.

Interestingly, present and past dialogue efforts in Central Eurasia go hand in hand with positive trends in education, which for the last decade or so, has experienced quite a renaissance.[12] Hopefully, dialogue efforts combined with excellence in education will yield great fruits in the future in this important region of the world, which will benefit the whole of humanity again as during the region’s golden ages between the ninth and fourteenth centuries. There is hope that the dynamism of inter-cultural diversity which has prevailed for centuries on the Eurasian continent with its multi-ethnic, multi-linguistic and multi-religious characteristics will gain momentum in future again.

Dr. Zhandos Utegulov is researcher at University of Nebraska–Lincoln.

Notes

1. http://cesww.fas.harvard.edu/

2. Huntington, Samuel P. 1993. “The Clash of Civilizations?” Foreign Affairs 72(3): 22-49.

3. Ali Unal, Alphonse Williams eds. Advocate of Dialogue: Fethullah Gulen, 2000, The Fountain Publications.

4. http://www.accd.edu/sac/history/keller/Mongols/states3.html

5. Janet Martin. Medieval Russia, 980-1584, CUP, 2008.

6. http://www.jewishsf.com/content/2-0-/module/displaystory/story_id/19476/edition_id/395/format/html/displaystory.html

7. http://www.eajc.org/publish_gen_e.php?rowid=40

8. http://www.religionscongress.org

9. Interview with Fethullah Gulen in Kazahstanskaya Pravda, Sept 15, 2006.

10. http://www.zaman.com/?bl=culture&alt=&trh=20061206&hn=38940

11. http://www.interfaithathens.org/article/art/10081.asp

12. Ismail Demirkan, Aksar Beketov. “Islam, Science, and Free and Open Inquiry,” Physics Today, January 2008, p. 11.

The Aral crisis is the best example of an ecological problem with serious social and economic consequences, directly or indirectly connected with all the states of Central Asia. The critical situation caused by the Aral Sea drying off was the result of agrarian economy tendency on the basis of irrigated agriculture development and volume growth of irrevocable water consumption for irrigation.

The Aral Sea was once the fourth biggest inland sea of the world, located between Kazakhstan and Uzbekistan (formerly in the Soviet Union). It moderated the inland climate for many centuries through water evaporation, which gave life to the surrounding deserts of Central Asia. The Aral Sea also was inhabited by more than one hundred fish species and supported productive fishing industries. Some fifty years ago the Aral Sea was surrounded by prosperous fishing towns like Moynaq.

The water area of Aral has periodically expanded and contracted in the course of history. These changes have affected the climate and the state of the region and led to important migrations in history. In spite of the massive glacier melting in the North and South Pole because of global warming, which would be expected to increase the level of inland waters, the Aral is rapidly losing its water. Because of poor environmental planning and the negligence of humans, the Aral Sea is now dying and according to the experts it will disappear in less than ten years.

The Aral Sea started to dry off in the early twentieth century. In 1918 Lenin decided that the only two water supplies of the Aral, the River Amu and the River Syr should be diverted for irrigation of the desert to increase land for agriculture. The idea was to boost agriculture, and this worked for a short period of time. The Soviets or Uzbekistan became the world’s largest exporter of cotton, which they referred to as white gold. The area of irrigated lands increased from 3 million hectares to 8 million. The population of the region increased from 7 million (1940) to 50 million (2000). At the initial stage of this project which seemed a brilliant idea at first sight, the irrigated land built up the economy of the Central Asian Soviet States and produced millions of jobs. Although, the result of the project was brief joy and success, the price of poor planning turned out to be by far too high.

First of all, the government had decided to grow cotton in a desert terrain. Cotton farming requires lots of water, which would not occur naturally in the desert. They also increased the production of other crops like water melons, cereal, and rice. Diverting the rivers cut the supply to the Aral Sea, and due to evaporation, it began to shrink. The first irrigation canals were initiated in the 1930s; however, these canals were poorly built, extremely inefficient, and wasted more than 50% of the water. Even today in Uzbekistan only 12% of canals are leakproof. The level of the sea has gone down constantly ever since; in the 1960s it became obvious that the sea level was falling; there was an average 20cm fall per year until the 1970s, when the fall became 50–60cm a year, and now it is 80–90cm a year. Especially in the period of 1960–1980 the diversion of water doubled, which reflected on cotton cropping as much as on the decreasing sea level.

The loss of water exposed the salty sea bed in the Southern Aral. Dust storms spread salty soil into the irrigated areas. Farmers tried to fight against salt contamination by flushing the soil with large volumes of water, which makes its way back to the sea. In addition, farmers used high levels of pesticides and fertilizers to increase the efficiency of crop production. However, these chemicals leave traces of nitrogen and other salts in high amounts in the soil. By flushing the soil with water to reduce salt levels, pesticides and fertilizers were also washed out and further polluted the sea.

Even more unsettling is that the Soviet government knew that they would lose the Aral Sea; in 1968 an expert said “it is obvious to everyone that the evaporation of the Aral Sea is inevitable”; and they also knew that fishing would be hit but the sad fact is that the government saw the Aral as an “error of nature.” The consequences of cutting the Aral’s water supplies and the irrigation of the desert were the beginnings of serious ecological and social problems in the 1960s. The sea was lost to fishing and transportation. This business of “killing nature” has not only affected the people living in the immediate vicinity of the sea. They did lose their jobs and they had to restart their lives, but the whole environment was affected too. Loss of water caused an increase in the overall salinity of the sea. Besides that, the bed of the sea, which held toxic chemicals and pesticides, was now revealed. The local drinking water is hence contaminated. The Aral was once the habitat of more than 120 unique species; now it has only thirty-eight. Being a heat reservoir, it had a cooling effect on the environment, but now the temperature can go above 120 degrees, winters still being harsh. Poisonous dust and salt storms take their toll. Infant mortality, tuberculosis, cancer and lung disease are thirty times higher than normal levels because the water is contaminated by fertilizers, pesticides and salt.

Currently the sea has lost more than 60% of its surface area and more than 80% of its volume; as of 2004 the salinity is 45g/l, normal value being 10g/l. While shrinking, it has split into two lakes, the North and South Aral Seas, now 95 miles away from Moynaq, leaving vast areas of salty desert behind. A BBC reporter said, “What appears to be snow on the seabed is really salt. The winds blow this as far as the Himalayas. The children of Moynaq have made a playground out of the wrecks of ships which might have provided food and a future for them.” The drying out of the Aral may lead to even more serious consequences in future if measures are not taken soon. First, increased temperatures may lead to the degradation of mountain glaciers. This could be highly dangerous for the region because the glaciers feed the River Amu and River Syr, and they are the only remaining storage for the supply of fresh water and moisture. Second, the Aral’s sea bed emits massive amounts of salt and dust into the atmosphere. Polluted air is carried over the area by a powerful air stream. Traces of pesticides and salt from the Aral region are now found in the blood of penguins in Antarctica. Moreover, the pollution affects areas thousands of miles away, such as the glaciers of Greenland and the forests of Norway.

In 2003 Kazakhstan decided to make this split permanent by building a dam (Kokaral Dike) between the northern and southern parts. The restoration effort focuses on the Northern Aral which is small and less polluted. This seals the fate of the Southern Aral, and is synonymous with its vanishing. The northern water supply, the River Syr has been restored and diverted back into the sea. Although it will not be the same again for sure, planners think that fishing will be rescued and the North Aral Sea will stabilize the climate by smoothing out the high and low temperature extremes and increasing rainfall. The efforts have helped to lower the salinity level which has even allowed the reintroduction of fishing in this area. The result is surprisingly encouraging. There are other proposals like diverting the Volga, Ob, and Irtysh rivers but this would be very costly and could cause yet another catastrophe.

This story has everything in it. Humans who disregard the ecosystem takes the gift in nature for granted. As we can see, however, nature is not infinite and it is breakable. Hundreds of years may pass until the region completely recovers. The magnitude of the disaster is comparable in scope to those of Hiroshima and Nagasaki, and might be even worse. This is a great example of short-term greed and ill-guided economic moves disregarding the whole ecosystem and bringing consequences which have to be dealt with in the long run. In this particular case, there could have been other ways to avoid the damaging decision to cut the water supply of the lake fully, such as relying on a different type of crop which requires less water, or making more efficient use of water, and so on.

This disaster is a single example of the type of global catastrophe we might encounter again in the future. This being so it should be kept in mind when we think of our future. A lot of the damage humankind causes might still be avoided if we act firmly and quickly. This is not just necessary for our grandchildren or our children but even for our own generation since the consequences of ecological destruction are being seen more rapidly now. The widely known global warming cannot be belittled, and, as the Aral Sea example might have taught us, the consequences can be terrible. It is likely that more such unpredicted events will afflict us. Added to this, there are water pollution, deforestation, and the destruction of wet-lands. Every day we hear or read about these consequences of negligence and greed. But these geographical features are all in perfect harmony, and we cannot rudely and unthinkingly destroy them. As Lester Brown comments, “Previous generations have always been anxious about the future, but we are the first who decide if the Earth inherited by our children will be inhabited.”

Timur Ceylan is an expert engineer at AMD Technologies, San Francisco.

References

• National report: “On the environment state and use of natural resources in the Republic of Uzbekistan.” State Committee on Nature Protection of Uzbekistan. Tashkent, 1998.
• K.Isentaev. “Geological structure and perspectives of oil and gas reserves of the Aral Sea.” Workshop report. Almaty, 1997.
• Ministerial conference of Central Asia. “Assessment of the environment.” Aarhus, Denmark, 1998.
• J. Mahambetova. Non-government union. “Aral tenizi.” Aralsk, 1999.

For that reason, the region constitutes a vast, natural pharmacopoeia. Plant and animal tissues obtained from the rain forest are used in the production of chemicals of known medicinal potency. (The ingredients for the best known drugs are extracted from the tropical plants.) So far less than one percent of the Amazon’s plant species have been studied for their possible curative properties (McGee, 1990, pp.516-17).

In contrast to the wealth of its flora and fauna, the soil of the Amazon is poor, so poor that, when large areas are cleared up, the regeneration process may take as long as 300, in some places even 1000 years (Giamo, 1988, p.539). But, the forest is rich in various natural resources: deposits of manganese, aluminium, copper, tin, nickel, iron, gold and natural gas have been found. Annual production of these minerals is worth about 1.5 billion dollars (McGee, 1990, p.515).

The region as a whole is vital to the maintenance of the world ecological order; it is an important factor in world weather patterns; nearly half of the world’s oxygen atmosphere is released from its vegetation; and approximately two-thirds of the world’s fresh water is stored in the Amazon basin.

DEFORESTATION OF THE AMAZON

Today, one of the most serious problems facing the international community is the uncontrolled destruction of this unique environment. Deforestation of the Amazon region is being done by all nine states sharing the region, though Brazil, 59% of whose territory is located in the Amazon basin, is the most active. Over the last three decades, the scale of destruction has become intolerable. There are no precise figures; the estimate is a loss of 13.000 sq. km. of forest annually. The total destruction of the Brazilian Amazon so far amounts to 415.000 sq. km., an area about the size of Iraq (Cerrill, 1992, p.44). Pessimists expect the Brazilian rainforest to have been largely destroyed by the first decades of the next century, despite a fall in the rate of destruction (ibid).

In a global perspective, the destruction of the earth’s lungs (for that is what the rainforests are) raises two problems. First, the increase in carbon dioxide (CO2) emissions into the atmosphere. In 1988 an estimated 12,000 sq. miles of Brazilian forest, an area larger than Belgium, was set alight to clear land for agricultural use. Excessive CO2 emission from such fires is among the main causes of the so-called greenhouse effect: Amazon deforestation contributes nearly five percent of the total CO2 emissions worldwide; the region as a whole stores in its flora 0.75 billion tons of carbon (Linden, 1989, p.46). The increase in the temperature of the earth’s surface will bring about climatic chaos, threatening the future of the global ecosystem including mankind. Second, deforestation goes hand in hand with the destruction of fauna and flora. It is estimated that every day one species becomes extinct (Goldenberg and Durham, 1990, p.26). If the Amazon rainforests vanish, more than a million species, a significant portion of the earth’s biological diversity and genetic heritage, will become extinct (Linden, 1989, p.45). The scale of the danger can be simply illustrated: 900 species of fig provide essential nutrition for spider monkeys, peccaries (a variety of pig) and toucans, for over three months of every year; the figs themselves depend on pollination by wasps–if the wasps go, all species higher up on the food chain go also: the monkeys and jaguars would disappear.

The well-being of the generations to come is dependent upon the preservation of biological diversity. Failure means that our children will be deprived of the opportunity to discover or modify pharmaceutical compounds from the genetic diversity that is now available but would then not be. And that lack would be felt also in the agricultural sector where genes taken from wild species are used to interbreed with domesticated varieties to enrich and strengthen them. For example, the California barley crop, with an estimated annual value of $160 million, was rendered immune to the lethal yellow dwarf virus by a gene from a barley plant found in Ethiopia (Dobson, 1992, p.282). That is why even Westerners agree that ‘Brazil is very important to the international community because of its biological diversity’ (Cerrill, 1992, p.46).

The Brazilians are accused of constructing highways, colonizing the region through large-scale migration, ranching, mining and lumbering. In fact, all the Latin American countries who share it also share in the destruction of the rainforest. In some of these countries, the forest is cleared to grow coca for cocaine production. Many endangered plants and animal species are caught for export to the West’s pet shops. The local governments are unable or reluctant to enforce international agreements to protect the fauna and flora threatened with extinction.

The principal excuse for the ongoing destruction is widespread poverty, even hunger, in the countries concerned. One Brazilian president said ‘we cannot discuss the environment issue without taking into account the situation of poverty and misery in which three-quarters of humanity lives’ (Cerrill, 1992, p.46). We should ask ourselves why such poverty arises in a region which Allah has endowed with so much natural wealth and beauty.

ISLAMIC APPROACH TO THE ENVIRONMENTAL TRAGEDY

We should seek the reason for the tragedy of the Amazon region in the brutality of the international economic order, based on the crudest laissez-faire economic attitudes and a usurious financial system. Without doubt, it is the foreign debts of Brazil and other Latin American countries that are the immediate reason for the deforestation policy. Brazil is now staggering under a foreign debt of $120 billion.

As Umar Vadillo rightly says: ‘the problems of the usurious economy are becoming day by day more apparent and more pressing since they are connected to the very survival of man and the ecological equilibrium of the planet. Today no one has any doubts that the reasons for starvation in the world and the serious deforestation of the tropical forests lie primarily in the debts of those countries’ (Vadillo, 1991).

The World Bank, the International Monetary Fund (IMF) and the Inter-American Development Bank (IDB) have financed enormous highway and hydroelectric plants and other construction projects with the specific aim of exploiting the revenues from the destruction of the Amazon (Goldenberg and Durham, 1990, p.31). The policies of such institutions are meant to divert the natural resources of developing countries from serving the needs of their populations to financing usurious loans taken out for projects that benefit only particular groups (Mc Clearly, 1991, p.707). The loans do not help the mass of the people to develop sustainable economic projects. Instead, they oblige them to set aside their best lands to grow crops for exports (where prices are beyond their control) in order to earn the foreign currency to service the national debt. It is a vicious circle systematically used by the world’s financiers to grind down the poor so that they continue to be forced to invest, through Western banks, in the affluence of the West: for every one dollar invested by the Western countries in the Third World (whether as aid or as loans) ten dollars are repaid in interest.

The cost of this debt slavery is horrific. In Brazil, for example, three-quarters of the population are living in the cities, more than half of them without adequate water supplies or sewage systems (Cerrill, 1992, p.47). Even some Westerners are coming to accept that the developed world cannot continue its exploitation of underdeveloped countries with the cruel intensity of the past half century–such an attitude is unsustainable, as well as being morally repulsive (Mc Clearly, 1991, p.707).

As long as the Western banks press the Brazilian governments to repay loans and interests, the Brazilian people will be forced to exploit the rainforest to barely survive as debt-slaves: but this has repercussions on the global climate and eco-system we all share. One cannot help agree with a Brazilian Congressman who said: ‘The green area of Amazonia should be totally devastated … because the forest represents the paralyzation of the country’s development’ [quoted from O Globo (Oct. 19, 1977) in Giamo, 1988, p.537]. Recently, Western banks have come to understand the consequences of their policies and the danger they put themselves in: one official tries to clear himself of blame in this way: ‘Deforestation may be with our money, but it is very much against our philosophy’ (Timberlake, 1987, p.23). It is beginning to dawn on the decision-makers that the agony imposed on the South by the North will lead to a catastrophe that will certainly engulf the North too. This confession arises from the understanding, in the aftermath of the catastrophic events of the 1980s, that due to the delicate ecological balance of the global environment, the South and the North share the same destiny. One’s loss will certainly be the other’s.

The Qur’an categorically prohibits usury; for example, in al-Baqarah: O you who believe! Have fear of Allah and give up what is still due from usury. If you do not, then be warned of war from Allah and His Messenger (2.278). Also, the Qur’an reiterates many times the interdependence of the creation, its fundamental interconnectedness and unity. As a single example of this, consider the following verse from al-An’am: No creature is there crawling on the earth, no bird flying with its wings, but they are nations like yourselves (6.38).

The respect for other creatures required by this verse (Hamid, 1989, p.159) is well-illustrated in the report that the Prophet, upon him be peace, following his own reasoning, once ordered dogs to be killed, but then changed his position to harmonize with the verse. He explained: ‘If the dogs were not nations in themselves I would command them to be killed’ (Sahin, 1992, p.7). The care and compassion of this attitude, its patient refusal to exercise the power human beings do have, is surely an example of a sensitivity to the hidden purposes of Allah’s creation, its as-yet unrealized potential, that we find echoed in the pleas, now growing desperate in their urgency, that we respect and save ‘the bio-diversity’ of our planet.

Certainly, the All-Merciful and All-Powerful created this universe with a harmony and balance among its many, different elements: And the firmament He raised up high and, He set up the balance in order that ye may not transgress (due) balance (7.9).

It is an aspect of human civilization, gravely neglected in the West, that human beings should learn to hear that harmony, to feel that balance, and to seek to live in tune with the Creator’s purpose rather than in arrogant disregard of it. Man’s dominion is conditional on his being a steward of nature, not a ruthless, self-indulgent tyrant. To prefer the role of tyrant to that of steward is in reality, to prefer our self-destruction biological as well as moral. 

REFERENCES

• CERRILL, M. (1992) ‘Brazil’s two faces’, Time (June 8), pp.44. ft.
• DICKENSON. J. ‘ Too many trees: not enough wood? A review of recent Literature on Brezilian Aniazonia’ Journal of Latin American Studies, 18, pp.409-23.
• DOBSON, T. (1992) ‘Loss of biodiversily: an international environmental perspective’ North Carolina J int’l & Commercial Reg, 17. pp.277-309.
• ECOLOGIST, THE (1989) ‘Amazon Special Issue’,19(6).
• GIAMO, M.S. (1988) ‘Deforestation in Brazil: domestic political imperative-global ecological disaster’ Envilonmental Law 18, pp 537-70.
• GOLDEMBERG, J. & DURHAM. E. (1990)‘Amazonia and national sovereignty’ Journal of international Environmental Affairs, 2(1) pp.22-39.
• HAMID, A. (1989) ‘Islam: the Natural Way’, MELS PubI, Lcndon.
• LINDEN, E. (1989) ‘Playing with fire: destruction of the Amazon is one of the great tragedies of hislory’, Time (September 18) pp 44.50. (Based on research for US National Academy of sciences, 1982.)
• MC CLEARLY, R. M. (1991) ‘The inlernational community’s claim to rights in Brazilian Amazonia’ Political Studies, 39, pp.691-707.
• MC GEE, H. W. (1990) ‘The deforestation of the Brazilian Amazon: law, politics and international cooperation’, inter-American Law Review 21(3), pp.513-50.
• SAHIN.M. F. (1992) ‘Ãnsanligin iftihar tablosu’, Akademi No.73., Zaman. TIBERLAKE. L. (1987) ‘From Washington to Panama: buying destruction’ in Only One Earth:Living for Nature, Sterling Publ. Co. Inc., New York.
• VADILLO, U. (1991) The End of Economics, Madina Press, Granada.