In the northern hemisphere, where annual average rainfall is around 100 kg per square meter in cold and dry regions, boreal forests, with needle-leaf trees, dominate. The southern hemisphere is dominated by savanna; bushes and meadows occupy millions of hectares.. In these regions, natural fires can be the most important factor of ecosystem changes. When looking at the results of these fires, it sometimes seems they were preprogrammed as to when, where, and how they spread.

Examples of fire dependent ecosystems

The cone of the Jack Pine species (Pinus banksiana), which is widely distributed throughout North American forests, requires absolute forest fire in order to release its seeds. The cone of this species can remain on the trees without releasing seeds for years because of climate and the resin layer covering it. Seeds preserved in the cones wait for the next fire; the cone’s scales open with the heat generated during such a fire. The seeds then start their journey towards a piece of soil that they can grow into. Here the role of fire is very important, not only for the dispersal of seeds but also in preparation of germination. The high humidity and low temperatures in the forests of these regions delays the decomposition of fallen leaves. This layer of dead material over the mineral soil is another hindrance for seeds to meet the soil. When scales of the cones open with the help of forest fire, this thick layer of dead leaves is also removed, having burned down to create fertile new soil.

Another example of fire benefiting plants is the chaparral vegetation of the North American forest. This type of plant cover is composed of short, perennial wooden plants and annual non-woody plants. During the hot, dry weather of summer, this vegetative cover becomes particularly vulnerable to fire. A dark black cover composed of unburned parts, frames, and ashes of the plants is left behind. This sight, which is saddening at first, actually hides various beauties in it, and these beauties only emerge after a series of events.

Golden eardrops (Dicentra chrysantha), which is a member of the perennial Chaparral family, is deeply affected by fire. The seed of this plant requires a fire event in the germination season and should be exposed to smoke for at least 10 minutes.

The positive effects of forest fires can also be seen in the healthy survival of an ecosystem. Due to its thick bark, the widely distributed Ponderosa pine (Pinus ponderosa), of North America, is minimally affected by the low, medium level cover fires that happen every five to twenty years. The weak and unhealthy individuals in this dense forest get burned as a result of natural forest fires, leaving healthy, thick barked trees. This way, possible epidemics of harmful forest organisms, via these unhealthy trees, is prevented. In the meantime, due to periodic fires, dead cover, or fallen and dead trees are removed, thus preventing bigger fires.

In the eastern Mediterranean, brutia pine, yellow pine, black pine, aleppo pine, and stone pine can are widely distributed. Among these, brutia pine is spread across a wide area, especially in most fire sensitive regions. It is created with a thicker bark around the trunk compared to other pines. This species can be minimally impacted from low and medium level cover fires. On the other hand, seeds in the cones of brutia pine are thrown far away by the heat of the fire, reaching fertile germinating grounds, thus helping to spread the forest.

References

• Fuller, M. 1991. Forest Fires: An Introduction to Wildland Fire Behavior, Management, Firefighting, and Prevention, SD421.F84, Wiley & Sons, Inc., NY, pp. 238.
• Keeley, J. E. 2007. “Chaparral and Fire,” Fremontia, Volume 35:4, pp. 16-21.
• Bond, W. J., Wilgen, B.W. 1996. Fire and Plants, SE18HN, UK, Chapman & Hall, UK, pp. 259.

The first is the preservation of characteristic, long term data imprints that describes the development of an organism in the stable DNA sequences.

Second is the storage of medium term epigenetically featured data that is carried a couple of generations further down the cellular level. Epigenetic information is not stored within nucleotide sequences but in the chemical modifications of these sequences (like the methylation of repeated strings of GC dinucleotide).

Third is the storage of data generated as a result of dynamic interactions between proteins, RNA and DNA in order to adapt to the events and changes during cellular life cycle in the form of nucleoprotein or DNA-protein complexes.

The data generation and storage capacity of DNA in three different hierarchical levels and time periods demonstrates that genome plays a plethora of roles in cellular activities and heredity. Formatting of genome for its generation and storage of data is carried out via DNA sequences of various features. Genomic system is composed of repeating DNA sequences. DNA sequences (satellite) function as a marker as they repeat numerous times in various frequencies. Genome includes genomic folders similar to that of computer systems. These genomic folders, also known as the epigenetic index of genomes, are responsible for the remodeling of chromatin and the coordinated control of genomic functions. Repeating DNA sequences play a critical role in replication of genome (making a copy of DNA), dispersal of copied DNA into daughter cells and construction of support systems that enable organization of chromatins.

It is possible to better understand genomic functions in relation to examples such as memory sticks and hard drives that are used in electronic information systems. The difference between a genome as a basic data-information storage medium from a hard disc is that it can be replicated as required by its nature and these replicas can be transferred to daughter cells. Following examples could be given to illustrate that a genome gains function only when it interacts with various data processing modules in the cell.

1. A copy of genome is produced by cellular DNA replication system
2. Correct localization of each genome copy towards daughter cells is only possible when chromosome segregation system works (the centrosomes and microtubules)
3. The central transcription system is responsible for the copy of data from DNA to RNA. Different gene expression patterns are developed via regulation of transcription time and level with the help of transcription factors and a web of cell signalization.

Very intricately organized genomic system structures are designed through the successive combination of protein encoding sequences, signals distributed in various places and repeating DNA sequences. Formatting of genome resembles formatting of computer programs. Various repeated serial commands of computer software are used to allocate addresses to files independent of the original data contained; different computer systems use different signals and structures to manage programs. In a similar fashion, diverse living species often utilize repeating DNA sequences and chromosomal structures to organize the encoded information and to format their genomes.

Diversity and variation of repeating DNA sequences are building blocks that are constructed into different genomic system structures. Genomes of different organisms bear characteristic system morphology just like computers with various operating systems and hardware. For instance, animal cells are created as a good model to take and incorporate foreign DNA into their genomes. Genetic data transfer among organisms of the same kind is referred to as “vertical gene transfer” whereas transfers between different species, genuses and classes are called “horizontal gene transfer.” Mobile DNA sequences like transposons are very effective horizontal gene transfer agents.

Cellular differentiation and morphogenesis (formation of tissue and organ from cell) is not programmed completely in the primary structure of the DNA sequence. Components of modular programs are encoded in a flexible way and a continuous renewed and recombined arrangement is enabled when needed.

The reason behind creation of different organisms from a single genome is this utilization of such genomic structure. Metamorphosis, that is the development of different organisms like invertebrates such as a caterpillar and a butterfly, is a good example of this feature.

Two organisms from the perspective of the same genomic protein and RNA codes can be considered as two different species. Different genomic structures and repetition of sequences among different organisms are distinctive criteria for the identification of species since these features can lead to mismatch of reproductive cells, different expression patterns of genetic code sequences, and may cause ecological diversity as well. That is why repeated DNA sequences are very important in studying parental relationships. Today, microsatellite DNA as repeated DNA sequences are used to configure biological relations among individuals in forensic sciences. Plant species vary in respect to the repeated sequences in centromeres in their chromosomes; these variations are used for identification of species. Main determinants of genomic system structure are diversity, frequency, and genomic localization of repeated DNA sequences. To explain this with examples, we could say that successively repeated sequences at centromeres, telomere repetitions and transcription, packing of chromatin, repeated sequences that are spread throughout genome in charge of cellular functions like nucleus localization are the main elements of the genome system structure. Genome is a single integrated system that is controlled closely and remotely via communication webs that use repeated sequences.

While explaining the Qur’anic concept of the Manifest Record (36:12) Bediuzzaman Said Nursi, the great renovator of Islamic thought in Turkey in the twentieth century, wrote that the Manifest Record expresses one aspect of Divine knowledge that is related “more to the past and future than to the present. It is a book of Divine Destiny that contains the origins, roots, and seeds of things, rather than their flourishing forms in their visible existence” (30th Word, Second Aim).

Inspired from this view, a seed can be considered as a tiny adorned form of Divinely creative command as programs and indexes and as a determinant for those programs and indexes in the organization of an entire tree. Since the Manifest Record book, as a title of Divine knowledge and command, observes the past and the future rather than the present, the genome of a grain or a seed acts like a library and an archive in which the future and past of an organism is written.

Sequences encoding different information in DNA

Different information types corresponding with various DNA sequences exist in the genome. These DNA sequences that were considered junk for a long time because they were not coding proteins, have in fact been found to be responsible for an amazing array of functions in genomic structure. Some of these sequences include:

1. Group determining sequences that enable coordinated or successive expression of genes,
2. Sequences acting as a marker in charge of initiation and termination during transcription of DNA to RNA ,
3. Signal sequences responsible for conversion of primary immature RNA, sequences into smaller functional RNA molecules,
4. Transcription control sequences that determine the expression frequency of genes,
5. Sequences that identify and mark the initiation regions for intensification and remodeling of chromatins,
6. Sequences that make binding regions which affect the relocation of genome in nucleus or nucleolus,
7. Sequences that target regions where covalent DNA modification (methylation) with functional groups like methyl takes place,
8. Sequences that control and identify the regions responsible for initiation of DNA replication,
9. Sequences that make the structures which enable completion of replication at terminal ends,
10. Sequences at the segregation points that enable equal distribution of copied DNA molecules into daughter cells and centromere sequences,
11. Sequences responsible for guidance during repair of DNA bound errors and damages,
12. Start point sequences used for repackaging of genomes,

Recurring sequences exist in the genomes of many organisms and shows great structural diversity. Recurring elements function as an initiator or terminator for heterochromatin regions. Furthermore they form an important scaffold and binding spots for folding of DNA structure. As if they carry out the job of an architectural mold in specific shaping of genome to be packed into a very limited area. The ratio of repeating sequences in genome (60-90%) is much more than sequences that are encoding proteins and RNA (10-40%). To explain it with an example, chromosomes in human genome are made up of packages of protein-DNA such as heterochromatin and euchromatin. Heterochromatin regions usually make up the regions with no transcription whereas euchromatin regions feature DNA transcription.

The ratio of protein encoding sequences to the entire human DNA is approximately 1.2%. Around 43% of euchromatin regions are composed of recurring and mobile DNA elements. 18% of heterochromatin region is also made of satellite (dense repeating sequences) and mobile DNA elements. Therefore almost 50% of human genomic DNA is composed of these repeating DNA sequences. In bacteria however, these only make up around 5-10% of the genome. These sequences were described as parasitic and junk individual DNA structures up until today and still continues to be described thus by many researchers and scientist. Nevertheless, even today, mobile DNA elements and repeating sequences are accepted as genomic parasites. Recent advances in the last ten years that have demonstrated this is not true, have instead revealed the vital importance of repeating sequences in genomic functions.

Repeating DNA sequences affect chromatin (dense pack of DNA and protein) structure in two ways. Irregular repeating DNA sequence copies contain binding regions for proteins that organize DNA. Heterochromatin (darker since it is densely packed chromatin) inhibits transcription and recombination, delays replication, and generally blocks the reading of information in DNA sequences that contain genetic coding. Heterochromatin regions are distributed throughout the chromosome. Because of this, presence of regions with coupled successive repeated sequences triggers heterochromatin formation.

In fruit flies, placement of protein encoding loci required for eye pigmentation near the heterochromatin blocks in centromeres (phenomenon of position effect) is provided via organization of chromosomes and thus, formation of phenotypic characters are inhibited. The “phenomenon of position effect” is convincing evidence that genome is a major system which is integrated with composition of partially repeating DNA sequences. When heterochromatin amount is increased in XYY male fruit flies, reorganized pigmentation of eye expression decreases. In XO males, when heterochromatin amount decreases, inhibition becomes severe. Changes in levels of protein which binds to special heterochromatin specific DNA regions generate opposite effects. Decrease in these proteins reduces or suppresses “phenomenon of position effect.” Surplus synthesis of these proteins also enriches this effect.

Repeating DNA sequences play an important role in the transfer of genome into daughter cells. For instance, they function in formation of the centromeres as chromosomal binding regions for microtubules, during gamete formation as linear terminals of chromosomes are replicated, and during chromosomal matching. Distribution of repeating sequences plays a major role in configuration of genomic functions. Each genome has genomic system structure that is shaped dependent on the amount of repeating DNA sequences to a major extent.

Going back to Nursi’s explanation of the Manifest Record, we can draw a parallelism between the book of the universe and the book of revelation, the first of which shows us that certain sequences in the genome are repeated for significance and necessity, just as many verses are repeated frequently in the Qur’an with nuances to refer to different meanings, benefits, and purposes, opening a wider space for many interpretations.

A genome is not only a book that contains protein and RNA codes, but also has a complex system structure with many functions for cellular vitality. The most needed sequences are those that are repeated more frequently. They are not pieces of junk DNA as predicted, they are jewels Divinely constructed.

References

• Shapiro J. A. 2001. “Genome Formatting for Computation and Function :Genome Organization and Reorganization in Evolution: Formatting for Computation and Function.” Presented at a symposium on “Contextualizing the Genome,” Ghent University, Belgium, November 25 – 28, 2001 (Ann. N.Y. Acad. Sci., in press)
• Shapiro, J.A. 2005. “A 21st century view of evolution: genome system architecture, repetitive DNA, and natural genetic engineering.” Gene 345, pp: 91–100.
• Shapiro J. A. and Sternberg R. V. 2005. “Why repetitive DNA is essential to genome function.” Biol. Rev., 80, pp. 1–24. Cambridge Philosophical Society.

The cell is the structural, functional, and biological unit of all organisms. All information needed for numerous processes in a cell, including repair and division, is contained in DNA (Deoxyribonucleic acid). DNA is a huge single molecule with intriguing features. How can a single molecule have such a dominant role in preserving information essential for the continuation of life? What are the mechanisms and levels of organization during its function? What does DNA mean for a single cell or for a human being? It’s impossible to answer these great questions in a single article; however, understanding the ways DNA exerts its role, DNA’s impact on multiple levels ranging from a single cell to an organism, and coordination between various levels, can potentially open up new frontiers in our mind and in our perception of life.

“Double helix” architecture of DNA DNA has an elegant structure that forms the basis for all of its functions. DNA is a repeating structure of nucleotides. Each nucleotide is formed of a phosphate group, 5-carbon sugar (deoxyribose) and a nitrogen-containing base attached to the sugar from outside to inside (See Figure 1a for a schematic view of DNA). There are four types of nucleotides in DNA, differing only in bases. We can consider bases as the identity of nucleotides. These four nucleotides are shown with letters A (adenine), T (thymine), G (guanine) and C (cytosine). Thousands of nucleotides bound with sugar-phosphate covalent bonds come together to form long strings. The sugar-phosphate backbone can be imagined as the steelwork of a skyscraper. The nice thing about nucleotides is their specific match to each other in double helix. A forms a base pair with only T, and G forms a base pair with only C. These pairs are bound to each other with hydrogen bonds. This feature is the key that makes DNA a double ladder. Two strings of nucleotides form a double helix by selective interactions of As with Ts, and Gs with Cs (See Figure 1b for 3-D structure of DNA). In DNA structure, hydrophobic bases tend to stay inside of double helix and hydrophilic sugar-phosphates stay outside interacting with water in nucleus. This feature helps DNA to form a double ladder. The length of the sugar-phosphate backbone is more than the bases. To compensate for the length difference, the sugar-phosphate backbone wraps around the bases inside, as a road wraps around a mountain to climb to the top. This simple difference is the main reason for DNA to form a helix.

The double-stranded nature of DNA with specific base pairing is one of its key features as genetic material. DNA is replicated using one strand as a template. Replication machinery reads one strand of DNA and builds the second strand by putting As against Ts and Gs against Cs. If a mutation occurs in one strand, it can be repaired using the second strand. This system is like photocopying DNA from itself instead of building it from scratch every time. That is why specific base pairing of nucleotides in the double helix makes it possible to replicate DNA through generations, protecting its integrity and information content. The code of DNA, an alphabet with four letters DNA contains the information to produce nano-sized cellular machineries called proteins. We mentioned that there are four types of nucleotides. Nucleotides are like letters in DNA, three of them are code for one amino acid of protein. We can make it more understandable by giving an example: “ATG-GCC-CTG-TGG-ATG” as a nucleotide sequence of DNA corresponds to the first five amino acids of a protein called insulin (a hormone regulating blood glucose level that is important in diabetes) and amino acid sequence is methionine-alanine-leucine-tryptophan-methionine. The code is so sensitive that even a single mistake in the sequence of DNA can cause serious diseases in humans such as sickle-cell disease or cystic fibrosis. With all these nucleotides, DNA can be thought of as a book containing amino acid sequence information for thousands of proteins (about 30,000 in humans). The amount of information contained in DNA is incredible: a typical human cell contains 2 meters of DNA that is tightly packed by proteins in the nucleus. If we tried to write the information from DNA into books, the book would contain over one billion words and 1,500,000 pages. DNA-protein interdependency and the cell as a micro-factory DNA can be thought of as an instruction manual that stores information for proteins and RNAs. Proteins, as molecular machines, perform particular tasks such as energy production and synthesis of DNA and RNA (See Figure 2 for the structure of proteins). Certain proteins read the information on DNA and make a transient copy of certain regions of DNA. These copies are called messenger-RNAs (mRNAs) and mRNAs are transported from nucleus to cytoplasm (See Figure 3 for representation of mRNA production from DNA by proteins). In cytoplasm, the information on mRNAs is read by protein complexes called ribosome. Ribosomes produce new proteins processing the data from mRNAs. This information flow from DNA to proteins is called central dogma in molecular biology (Figure 4). The data that is encoded in DNA can be read, translated, and put into the form of product only by proteins. We can conclude that for a protein to be produced, DNA is essential; for DNA regions to be read into proteins, proteins are essential. So, there is interdependency between proteins and DNA. Proteins without DNA have no future and no ability to regenerate and DNA without proteins is just like an instruction and manufacture manual of a computer without the user and computer itself. We can imagine the cell as a sophisticated factory, and proteins as the machines of the factory. DNA includes the instructions for the factory to be rebuilt and for itself to be rewritten for every new factory. It has instructions on how to build every machine in the factory. It has also codes for when and how much of these machines should be produced (we will discuss more about these codes on DNA in the next section). On the other hand, the timing and control of all these productions also depend on machines in the factory. Some of these machineries read and decode the instruction manual, some of them produce new machines by reading the decoded copies of the instruction manual, some of them act as sensors for the signals, some of them transmit signals to other machines, some of them produce signals by measuring the levels of materials in the factory, some of them function in communication with other factories, and so on. As we can see, DNA and proteins are meaningful for life only when they are together in the excellent cell context. This is a perfect example of the principle that the whole is bigger than the sum of its parts, because each element of the cell system has limited potential, until it comes together with the others to blossom into life.

The famous term “Gene” We can think of genes as functional units of DNA. A gene has the information content for at least one protein. Humans have about 20,500 genes that are read by protein machineries to produce proteins. Special proteins read the information on genes and make a transient copy of these certain regions of DNA. The process of making a copy of a gene as an mRNA is called transcription.

Genes don’t only store information; they have an intrinsic architecture of design to coordinate transcription utilizing three main components: promoter, coding region, and terminator. The promoter is the gene region that signals for the start of transcription. Protein machineries bind to the promoter and activate transcription. The coding region has the information for the amino acid sequence of the protein. The terminator region gives the stop signal for transcription. There are different functional regions on DNA located between separate genes such as enhancer regions that are platforms for binding regulatory proteins to tune the transcription.

The coding region of genes has multiple reading blocks for amino acid sequences and these reading blocks are called as exons. For some genes, different combinations of exons can be put together to give rise to different proteins. This mechanism allows one gene to be able to produce multiple proteins, increasing the efficiency of genetic material. A similar mechanism is used to produce antibodies (proteins recognizing foreign antigens) by the immune system. Different regional genes come together by a mechanism of DNA rearrangement (V(D)J recombination) and their differential combinations form many different antibodies. For example, a part of the antibody that is called a heavy chain is produced by a DNA region containing 65 variable (V) genes plus 27 diversity (D) genes and 6 joining (J) genes (5, 6). This produces a combination of 65 V genes x 27 D genes x 6 J genes = 10,530 heavy chains. There is a similar mechanism of rearrangement for light chain and variable region of antibodies, which result in millions of different antibodies for host antigens. A single example in the immune system shows us that DNA not only has a decent design for the coding system, but it also has ingenious and creative mechanisms to maximize its potential.

Gene expression is orchestrated during development and formation of organs The human body which consists of more than 1013 (ten trillion) cells is generated from a single cell called the zygote (see Figure 5). This tells us that, in a single cell, all the information and instructions to build and coordinate the systems of human body is encoded. Different tissues and organs including muscles, nerve cells, connective tissue, and eyes are fruits of one single cell. They all contain the same genetic information. Then what makes them different?

Promoters, enhancers, and repressors located in and nearby genes are important in spatial and temporal control of gene expression in different cell types of the body. Each cell type in our organs expresses a different subset of genes; this is what gives a cell its identity. For example, in muscles, myosin is expressed and in the eye’s retina, rhodopsin is expressed. Myosin functions in contraction and rhodopsin functions in vision. What determines the expression of rhodopsin in the eye but not in a muscle? The determination process occurs during development by programmed interactions of specific proteins called transcription factors, and restricted regions of DNA including promoters and enhancers. During development, certain regulatory proteins in a specific cell type, bind to DNA regions of only some genes (for example, in future retinal cells of the eye, rhodopsin gene would be activated but not myosin) and this predetermination orchestrates differential expression of genes to give rise to hundreds of different types of cells.

Different layers of complexity and organization related to DNA

There are different layers of function for DNA—each subtitle of this article tries to focus on a certain layer of function. DNA as a molecule has a double helix structure and is replicated through generations to preserve genetic information. It stores genetic information and has a four-letter alphabet for the expression of proteins. In the second layer, DNA has an informational unit called gene and thousands of genes are encoded in DNA to contain information for proteins. Each gene is controlled individually by making use of promoters and enhancers. In the third layer, all processes in the cell micro-factory as an entity are performed through interactions of DNA and proteins with each other and among themselves. Proteins read DNA code and work as cellular nano-machineries. In another layer, temporal and spatial expression of genes on DNA are orchestrated and different subsets of genes give rise to different cell types and organs. Organs communicate with each other to function properly and keep the balance and homeostasis of the body. The information stored in DNA not only coordinates highly sophisticated processes of a single cell, it simultaneously projects the whole body system of a human being, which is billions times bigger than a single cell.

DNA functions in all these different layers and keeps a great harmony in coordination between various layers of function. After grasping this complexity, organization and communication from a single molecule, to proteins, to a single cell, to tissues and organs, and to a human being by utilization of DNA, should not we ask ourselves, “can these elements come into existence by random forces and collisions?

References

1. Calladine, C. R. et al. 2004. Understanding DNA: The Molecule and How It Works, Academic Press

2. http://www.genome.gov

3. Li A, Rue M, Zhou J, et al. 2004. “Utilization of Ig heavy chain variable, diversity, and joining gene segments in children with B-lineage acute lymphoblastic leukemia: implications for the mechanisms of VDJ recombination and for pathogenesis.” Blood 103 June (12): 4602–9.

Introduction

Human beings have wrestled with questions about the origin of our existence and the fabric of our universe for thousands of years. This questioning formed the discipline of cosmology. Dr. Natarajan explores the nature of our world and shares her perspectives about how new scientific discoveries are reshaping our understanding of the universe and our place in it. Until very recently, the universe had been considered a vast empty space. But the Dark matter theory states that the universe is not empty, but rather filled with an invisible matter. As new mysteries unfold, Dr. Natarajan points out that it is our fundamental human curiosity that leaves us no choice but to explore the universe and how we fit into its grand picture.

M&B: Dr. Natarajan, you work on dark matter in the universe. What is the theory?

It turns out that the bulk of the matter in the universe is not made of ordinary atoms that you and I or the universe that we know and experience is made of, but instead made of this mysterious particle. Ninety percent of all the matter in the universe is dark matter, and we believe this is a set of particles that was created very early in the universe. These particles do not have charge, but they have mass. Since they dominate the mass of the universe, it turns out that they really form the scaffolding in the universe around which all galaxies, stars, and so on, form. They are sort of the basis or the framework within which normal atoms actually cool to form star galaxies, and then have generated us.

M&B: What is the evidence for their existence?

The reason dark matter remains a mystery, – although there is incontrovertible evidence for the existence of dark matter – is the fact that you only detect it indirectly. What I mean by that is you detect its presence because it has mass, and since it doesn’t have any charge it doesn’t couple to any radiation. So you don’t see radiation in any wavelength in the electromagnetic spectrum: no X-rays, no gamma rays, no visible light, nothing. But since dark matter has mass, it aggregates gravitationally, so they feel gravitational pull towards each other and they cluster. It’s the clustering of the dark matter, the fact that it gets compact, that we detect the effects of dark matter.

M&B: What happens near the regions where dark matter clusters? In your research papers you use the bending of the light rays. How do you observe it?

The primary evidence is the gravitational bending of light produced by these aggregates of dark matter. The universe is really composed of a smooth distribution of dark matter, with a lot of clump regions where this dark matter has aggregated, and then enabled the formation of galaxies. The presence of these large amounts of dark matter causes light from background galaxies coming towards us to bend. The actual shapes of galaxies that are behind a big clump of dark matter, which is along our line of sight, are actually distorted when we see it. The dark matter in general is smoothly distributed everywhere in the universe. But there are these particular regions that are denser. So we can look at regions in which the dark matter is not so densely distributed, look at the shapes of undistorted shapes of galaxies, and then use that to infer how much distortion we’re actually seeing when we see a lump, and infer its existence from the distortion. Because the strength of the distortion is directly proportional to the mass, you can directly infer how much mass there is between us and those objects.

M&B: Is there evidence other than the bending of the light rays?

The other evidence eludes to the fact that dark matter actually gives the basis for the formation of stars and galaxies. If you look at the motions of stars and galaxies, you find that, unlike the solar system, if you look at the velocities of the planets in the solar system as a function of distance from the sun you find that it’s falling. So the planets in the inner regions are moving very fast; they feel the gravity of the sun much more strongly than the outer planets, which are not actually moving as fast. So if you plot the velocity from the center or from the sun outwards in the solar system, the velocities are falling. Whereas if you go to a galaxy and you do the same experiment, you look at stars at different radii and you try to see what their speeds look like. They are speeding up as you go outwards. And the only way they can do that is there is something that is sitting outside the galaxy that holds it up as it were, and has gravity. And it turns out that our current picture is that most galaxies have very extended dark matter halos. The key point is that there’s a lot of dark matter sitting outside the galaxy well beyond where we see the stars.

The other compelling lines of evidence for the existence of dark matter come from larger scale observations of the universe. One of the leftovers of the big bang or relic of the big bang is this microwave background radiation that is detected today in the universe. It was a very hot radiation that has cooled with the expansion of the universe, and we are bathed in it. I mean it’s everywhere, in every direction, and measurements of the directional dependence of the microwave background shows that it’s very uniform. But in one part it’s anisotropic, so there are cool zones and hot zones in the sky. On very small scales we see these cold and hot spots. And these and isotropy’s in the microwave background are exactly predicted by this model, the cold dark matter model, which I said you know is postulated on the very early generation of the universe and these dark matter particles.

M&B: So we know that they exist. But what is their essence? What are their properties?

This is still a mysterious kind of beast. In fact, we don’t know the nature, but it appears that it’s collisionless. It’s very counterintuitive. That’s one of the things I find fascinating about the fact that it is so counterintuitive. These particles are actually collisionless. What that means is that when two dark matter particles approach each other, they pass through each other, they don’t actually bounce off of each other, so these particles don’t collide, which means they don’t have pressure, because pressure is generated by collision. So they are pressureless particles that have mass. Gravity holds them together, but they don’t actually collide.

So a current understanding of dark matter is that it’s definitely generated very early in the universe and that it clusters very strongly and it’s distributed on very different scales in the universe, so there’s like a smooth background and there are lots of clumps on top of it and so on.

M&B: As far as the mass of Dark Matter how much mass are we talking about? If there is no clustering, something like in the volume of the earth, for example, how much total dark matter mass do we have?

Well I guess the thing is at the position of the earth and at the position of the sun from the center of our galaxy. We are not really dominated by dark matter anymore, so dark matter at that radius doesn’t constitute significant portion of the mass. We are bathed in it, but the density is quite low. It’s at the innermost part of our galaxy where the density is very, very high, so we actually expect that the inner most regions of our galaxy is a very complicated, violent place where not only do you have a black hole which we know exists. This is a black hole that is not made of dark matter. This is a black hole that has gobbled gas and grown to about a million times the mass of the sun, and which is sitting at the center and it creates a very violent place for stars because it can rip them apart and so on. And this whole system is sort of embedded in this very, very dense region full of dark matter.

M&B: How is your everyday work? Where do you get data about the light rays coming near the regions with high Dark matter density?

A: I’m a theoretical person and what that means is that I actually build models but models that are guided by observations. The theory has transformed in the past 10 to 15 years because of the amount of data that technological progress has given us.

For example, the Hubbell space telescope has really transformed the kind of modeling that can be done. So I actually use data that other people have procured. They’ve cleaned it up and they give it to me. These are very distorted images of background galaxies whose shape has been distorted because of the huge amounts of dark matter that is contained in a cluster of galaxies.

M&B: The bending of the light rays is predicted by the general relativity theory. Is it what you use for your calculations?

A: It’s a beautiful theory. I think that people really have understood the iconic status of Einstein. What is most fascinating about him for me is the profound insights that he had of such despaired phenomenon. There was a way in which he was able to see connections and synthesize. You know the whole understanding that the geometry, the fate and the contents of the universe ought to be linked is a profound insight. And I think you know it’s incredible that he enabled, you know, his mind enabled him to formulate it in the way that he did, which has allowed people like me to use general relativity and the sort of elegance of general relativity because of how simple it is in fact to apply and test.

M&B: This looks like an intriguing line of work?

I want to stress that this is a particularly wonderful time for cosmology. It’s a particularly special time. I don’t want to use the sort of often abused golden age as it were, but it’s the confluence of technological progress with the kind of data that we can obtain and the level of understanding that we have built up. This is a very special time to be doing this kind of work. And while the mystery of what dark matter might be made of, you know, it may or may not get solved in my lifetime.

M&B: If you want to describe your work, what term would you use?

In a more descriptive way, I guess. What I really do is I build a story line. I build a story line for the universe. I mean, I build a story of the sequence of events of how a structure forms and assembles. The key there is that you are guided, you have a few snapshots, so you have a bit of data, but then you have to extrapolate and you make some predictions. The goal of the kind of work that I do is to make predictions, and have them be taken seriously, to either be falsified or shown to be true, and what’s exciting about this particular time is that people can falsify your theories or your models in a very short time.

M&B: Isn’t it interesting that we can actually make a story out of universe?

Well, I mean, I think that what is fascinating, and this is a personal view, what is fascinating about cosmology is the… you know it’s mystical and it’s mysterious at the same time and it’s highly abstract. It’s not intuitive because the scale that I’m working with in terms of distances, masses, and energy are just unfathomable. So there’s a real irresistible pull for certain kinds of people to do this kind of work. And I think the universe is a pretty good subject for a narrative because of the range of phenomena that occur in it. This is possibly why in all ancient civilizations there is some notion of cosmogony and this idea of fascination with where we came from. I don’t want to sound arrogant by saying that it’s the fundamental question, but you know it’s an inescapable question for anybody to ponder where we came from.

M&B: Is there a sense of awe that motivates you in your studies?

There is a sense of wonder that the universe generates and I think that you know personally for me I’m a bit of an adventurist, and I think if I can imagine myself, if I had been born 200, 300 years ago I would have been one of those explorers. And I think there are people like that amongst us always, who want to explore in different ways. I mean, there are some people who want to explore via music. And there are frontiers that they want to break through in music, and they have the creativity to do that. And I think that for a lot of us who are doing science, and cosmology in particular, there is a sense of exploration, there’s a sense of examining or grappling with things that are really at the limits of our capabilities in a way.

M&B: In some ways one of the most important fruits of the process and coming along it’s our imagination. And the human imagination is also a part of the universe.

Absolutely. It is an inescapable part of the universe and what is fascinating is the idea that we have the capability to even contemplate the origin of the universe given that we are a part of the universe.

M&B: Many people approach science in a utilitarian way and this is not what you are doing.

I think that the fact that it is not utilitarian is precisely what attracts me to it. I think it is the other side of the coin of this, which is why we probably aren’t as well funded and we ought to be better funded than we are, because this is such a fundamental human curiosity. There is enormous public interest in what we do and the level of funding that we have does not reflect that. For instance, obviously medicine is very critical. It’s critical to our existence. But the disparity in how they are funded and how the pure sciences are funded is sort of disturbing. Because I think as a culture, as a world, we can afford to indulge in understanding basic sciences partly because there are spinoffs from all the work that we do. It is unpredictable, and I think that is what’s fascinating. There are no guaranteed benefits to human kind and society today that cosmologists can bring. However, they satisfy this hunger for knowing and going beyond, you know, satisfying your hunger and thirst on a day to day basis.

Mustafa Tabanli is a producer at Ebru TV. He conducted this interview for Emmy Award winning television series Matter&Beyond.

Bio

Dr. Priya Natarajan is a Professor of Astronomy and Physics at Yale University, and an Associate at the Dark Cosmology Center, which is part of the Niels Bohr Institute at the University of Copenhagen, Denmark. Her research interests include cosmology, gravitational lensing, and black hole physics. She earned a B.A. degree in physics and mathematics at M.I.T. and her doctorate at the Institute of Astronomy, University of Cambridge in England, where she was a member of Trinity College and elected to a Title A Research Fellowship that she held from 1997 to 2003. She is currently on leave from Yale to take up her Guggenheim Fellowship. She is deeply invested in the public dissemination of science and is currently a member of the Science Advisory Board for the public television series NOVA.

http://www.astro.yale.edu/priya/

On the face of the Earth, mountain regions are defined as areas more than 1000 m in elevation. Although mountains cover only 27% of the total land area of the planet, the percentage of the world population who are dependant on the mountains is much larger. In terms of water dependency, about 70% of the population uses water originated in the mountains. This ratio becomes close to 100% in arid regions. Interestingly, the water towers of the world are generally located in the arid regions of the world. It is not unusual to see an arid lowland region with a big river crossing it. These regions are usually connected to a nearby mountain from which the river originated. The significance of the mountains is mentioned in the Bible as the following: “For the Lord is the great God, the great King above all gods. In his hand are the depths of the earth, and the mountain peaks belong to him. The sea is his, for he made it, and his hands formed the dry land” (Psalm 95:3-5).

All great rivers of the world originate in mountains. For example, the arid region of Central Asia is watered by the Tarek, Amu Darya, and Tarim Rivers. All of the big rivers of China and India originate in Tibet. Pakistan is dependant on the Indus River. Asia Minor and Northern Arabian Peninsula are supplied by Euphrates and Tigris Rivers while Northern Africa is supplied by Nile River. All Australian waters are supplied by rivers originating from eastern highlands, and Europe is supplied by the Po, Rhine, and Tiber Rivers, which originate in mountainous areas. This makes mountain water strategically important in these areas, and in fact, some countries prefer to keep their need of mountain water a secret!

Here it is worth discussing the global water cycle in order to understand the peculiar role of the mountains. All of the precipitation onto land comes from evaporation on land and oceans. A significant portion of the land precipitation goes back to seas and oceans via river discharge every year. And the main source of fresh water for humans and other living organisms comes from rivers. For low-land precipitation (as opposed to mountain precipitation) the discharge happens rather quickly, within weeks. Therefore, humans build dams in order keep the water for longer periods of time. Another longer term solution to keep more water on land is planting trees, which benefits not only humans but all other living creatures!

For mountains, the water cycle works quite differently. Since the mountains are in high elevations, precipitation starts early in the late fall and continues until the end of spring. The river discharge does not begin until early summer. Especially in arid regions, the low-land discharge mostly diminishes by early spring, and no predictions can be made as to how arid the coming summer will be. On the other hand, because of lower temperatures in the mountains, evaporation is also minimal, which makes them efficient natural storages. At the end of spring when the lowland precipitation starts to diminish, the mountain water discharge begins in a steady manner and continues during the entire summer season. When we look at the yearly usage of water even in a humid region like Europe, more than 50% of the water during the hottest and driest months of June and July is released from the Alps. This percentage is more than 95% in arid regions of the world, such as Mesopotamia and North Africa. The Holy Quran mentions the storage of bounties, including water, explicitly as the following: “There is not a thing but the stores (for its life and sustenance) are with Us, and We do not send it down except in due, determined measure. And we send the winds to fertilize; and so We send down water from the sky, and give it to you to drink; it is not you who are the keepers of its stores” (15/21-22).

Since lowland water discharge is mainly controlled by precipitation, it is also unpredictable and rather quick. This is particularly inconvenient for farmers who have to make business plans for the entire of the year ahead of time. The knowledge of yearly precipitation is vital for farmers to make reliable investments. In lowland areas, prediction of water distribution months in advance is very difficult, and almost impossible before it actually precipitates! (In fact, an area of geological sciences is devoted to forecasting precipitation. This is also important for preventing causalities in potential floods). On the other hand, mountain discharge offers stability during the year, which makes life much easier for farmers.

Mountains are generally seen in our distant horizons of our living areas with their magnificence and silence. They have many benefits that we may or may not be aware of. Indeed they are the water towers of the world.

H. Huseyin Erdem is an earth scientist living in the USA.

Note

1. More discussion on this topic may be found in The Risale-i Nur Collection (e.g., see The Words, 33rd Word) by Bediuzzaman Said Nursi.

References

1. Wiegandt, Ellen (Ed.), Mountains: Sources of Water, Sources of Knowledge, The Netherlands: Springer, 2009.
2. B. Messerli and J.D. Ives (Ed’s), Mountains of the World: A Global Priority, Parthenon Pub., 1997.

Decisions within the cell: mathematical and algorithmic character

In order to enable Escherichia coli bacteria to use lactose (disaccharide), the genetic information of the enzymes that have role in transporting the lactose into the cell and converting it into glucose is coded in the bacteria’s genome. The binding and decoding structure which enables the genes to be transcribed at the right time in the appropriate amount is called the operon. The operons are model mechanisms which work on the synthesis or destruction of every chemical molecule (metabolite). One of these, lactose operon, is a good example that demonstrates how the decoding information contained in DNA is regulated and controlled in the bacteria. E. Coli is equipped with a system that distinguishes lactose and glucose when they are combined and this system functions perfectly. Primarily, all of the existing glucose is consumed before the start of the production of those enzymes that splits lactose into glucose and galactose. It has been discovered that this operation in the bacteria is followed by an interaction between DNA sequences located on the upper part of the lactose gene and various molecules. The DNA sequences on the upper part of the gene are the signals that format DNA for transcription. These signals cause the decoding of the genes that interact with the transcription factors. While some of the signals in the relevant region of the genes are common in most genes, some others are specific.

The most basic interaction system of the genome-proteome (all proteins in cell) is the suppression of the lactose operon that is observed in E. Coli. This process depends on DNA-protein interactions which are based on a mutual relationship and it requires the existence of repeated DNA sequences. Tetramer lac1 protein control the lac operon binds to four repeating binding regions on the DNA. Since one dimer can be connected to one operator sequence, two dimers are connected to two operator region units, and as a result the result is a loop formation in the DNA structure. Consequently, because of the access of RNA polymerase to the promoter region, the pre-coding process of genes is hindered. If the hindering protein is in the form of a monomer, the operator displays a weak interaction with half of the sequence. In the dimer form there is a stable binding. For this reason, many procedures in the cell occur by working together and making a union of molecules. Since the loop shape of DNA stabilizes the structure, it prevents the RNA polymerase from being connected to the promoter region. In order to eliminate the blockage on the lac operon, the mutual relationship must be prevented by stimulatory molecules, such as lactose.

There is metabolic information in cells that measure and control the physiological condition. The sequences on the regulatory region of the lactose operator and the data concerning the physiological condition of the lactose and glucose metabolisms are analyzed in the cell which perceives the presence and the amount of glucose through the changes in the system that transports the glucose into the cell. The molecule that announces the presence of glucose in E.coli is cyclic-AMP and concentration of this molecule in the cell is inversely proportional to glucose. The level of this signal affects both the coding and regulation of genomic information. The protein that transports glucose into the cell contains a phosphate group; as it transports glucose into the cell, this carrier protein phosphorylates the glucose molecule thereby loosing its phosphate group. As a result, the proportion phosphorylated transport protein and those without phosphate provides information about the glucose level in the cell. The phosphorylated form of the carrier protein activates the adenosine cyclase enzyme. Through this enzyme, ATP is converted into cyclic-AMP. The cyclic-AMP level increases in the cell. Consequently, the situation that concerns the increasing concentration of the phosphorylated transfer protein and the cyclic-AMP is interpreted as non-existence of glucose in the cell. The CRP protein that binds to regulatory region of the lactose can only bind to this region in the presence of cyclic-AMP. The cyclic-AMP-CRP complex which is tied to the promoter region of the lactose gene speeds up the transcription of the lactose operon. Transcription rarely happens when there is no lactose. This is because the lactose repressor protein lacI, hinders the RNA polymerase reaching the lactose promoter region by binding to the operator of regulating region. The cell can sense the existence of lactose in a circuitous manner. Low levels of coded Permease enzyme on the lacY region transfer some lactose into the cell. The coded beta galactosidase on the lac Z region alters them into a sugar called allolactose. The allolactose is bound to the lacI repressor protein and changes its conformation. The allolactose –lacI repressor complex can not bind to the operator region. The promoter region, called LacP, of Lactose operon is set free for transcription. In fact, every one of these molecular interactions is an incident of information being transferred. All these incidents demonstrate that an algorithm (If there is no glucose and only lactose exists, then transcribe the lacZYA enzyme) that is able to distinguish the difference between two sugars exists in bacteria cells and that it functions perfectly.

In short, the signal transfer in lactose operon occurs with the activation of chemical molecules that represent the experimental data pertaining to the physiological environment of the cells. For example, the levels of cyclic-AMP, allolactose and protein phosphorylation indicate the existence of glucose and lactose. The regulating network system, on the other hand, combines many aspects of cell activity (transport, enzymology, energy metabolism) in order to make the transcription decision. Briefly, it is impossible to show that arranging the order of the genome in any cell occurs independently from physiological or biochemical processes.

The principle of “using combinations in the arrangement of specific binding regions” is commonly used in metabolic signal networks that control cell physiology and the differentiation of cell (morphogenesis) that are oriented towards tissue formation. Such an interaction takes place on these network paths between proteins and DNA sequences to ensure that the cell is allowed to process molecular information and to calculate whether it will transcribe a specific genetic sequence. The common binding regions on DNA have vital roles in the coordinated control of various genetic loci, and it is then that the decoding of genes in a harmonious (symphonic) manner becomes possible. Various combinations of these regions are also used in making more complex decisions. As an example, protein-binding regions that are involved in the lowest level of genomic indicators have a role in decoding genes. The proteins that bind to these DNA sequences can become active when they form a group that has an interaction with more than one protein molecule. For instance, each one of the lacO and CRP regions on the lactose operon shows a palindromic sequence structure (the DNA sequence remains the same when the sequence is read from either end). Similarly, the lacP region has two lower regions that are appropriate for the binding of RNA polymerase and are separated from each other by a 16–17 base pair. In all living beings, the proteins and DNA sequences interact with each other. For example, the LacI repressor, which is in charge of controlling the lactose operon,has separate regions for not only binding the DNA region, but also for creating protein-protein binding as well as the binding of allolactose stimulator. The unique combinations of this region on the genome sequence result in a unique protein synthesis.

The genetic engineering procedures in cells

Some of the genetic engineering procedures that take place in the cells are as follows: Recombination systems (mutual material exchange) that are observed in homologous chromosomes (the chromosome pair derived from each parent), recombination specific to a particular region; separation of DNA sequences specific to those regions (fusion of gene pieces, VDJ recombination of genes as appointed in the immune system); the existence of systems that combine end points in non-homologous chromosomes (the binding of broken DNA parts, the formation of new genetic fusion, the formation of sequences that are open to hyper mutations); DNA transposons (DNA sequences that can insert themselves into different DNA sequences or can copy themselves there and leave a copy); the RNA sector that can control the transcription and signals that are responsible for the maturing transcription; the signal sequences that cause the rearrangement of neighboring DNA sequences (such as amplification, deletion, and inversion); and finally, controlling the transcription with micro RNAs.

None of the above phenomena which cause in-cell changes are random. Each of the genetic engineering functions is planned in a way that makes specific changes and arrangements. In the processes of insertion, i.e. when a specific amount of DNA is added to a different region of the genome, or deletion, i.e. when a specific amount of DNA is severed, there should be arranging, cutting and coding sequences that will bind the cut part to its new place in an appropriate way. On the genome, special regions that are suitable to mutation are created in order to produce variety and to respond to adaptation. When all these molecular engineering functions are thoroughly analyzed, it can be seen that even the point mutations, which up until now were thought to have happened by chance, are not coincidence; rather, they occur through the divinely designed genetic engineering functions. Most of the mutations that are thought to occur by chance in the cell have been removed by the repair systems and fault correction functions in the cell. Thus, the changeability and variety in DNA sequences are shaped by the power and will of God the Almighty according to a planned, programmed genetic schedule.

The R&D department of the genome

Depending on the stimulation received, God-given genetic engineering functions are arranged in the cells and a decision is made about which parts of the genome should be changed. Some of the changes inside the cell appear on a large scale. Inside the genome, different and far removed regions can be rearranged. The changes are related to one another and are in no way disconnected. One mechanism can produce more than one change. The reconstruction of changes in some organisms is a part of the normal life cycle. In the Cornelius protozoan, the embryonic genome is regularly decomposed to a thousand slices. Then, through processing and rearranging in the cells, a functional genome with a distinct system structure is created.

While the genome is reshaped, there is the production of new different sequences rather than the sequences that they regulate and which have the code for the continuity of existing phenotype features. The organization of the genome along the system base emerges with the functions of the genetic molecules, such as cut-paste-rearrange. For example, in immune system cells, there is a planned disposition to mutation and the specific antibodies are rearranged to recognize an infinite number of different antigens. The life cycles of lymphocytes demonstrates both the control of the DNA rearrangement improvements and the specificity of mutations. It is estimated that the new sequences which do not change the existing structure operate like a research center for the genome.

The God-given genetic engineering systems imposed in the cells, when analyzed from the perspective of the population, are molecular mechanisms that carry out basic changes to ensure adaptation. The duty of reconstructing the genome during adaptation has been assigned to the divine genetic engineering functions imposed in the cell. The divine genetic engineering tools and mechanisms, which are placed in the cell with active nucleic acid elements that carry information, change the genome in parallel to the changes in both the inner and outer environment; this change occurs not only on one point of the genome, but rather on every point of genome. The functions of the DNA elements, which allow for the exchange of genetic information (both horizontally and vertically, in species and between species, between types and classes), are arranged by domestic cell signal transfer and data process networks. The signal network systems that are in charge of rearranging and controlling in-cell procedures not only control when the genome is rearranged, at the same time it decides where these rearrangements take place inside the genome. The selection of the target is planned, it is not random. For instance, R1 and R2 retrotransposons which are established in the DNA region that codes 28S ribosomal RNA have specific recognition regions and the information of endonuclease cutting DNA region on specific points that it had settled down. Eukaryotic cells have more complex decision making systems. The cells continuously create responses in response to DNA damage, cell physiology and outer-cell reproduction factors. One of the critical questions and answers is whether the damage will be repaired or whether programmed death will take place. If the cell avoids giving an answer, then genetic indecisiveness appears and abnormal cell reproduction, i.e., cancer, begins. From this perspective, cancer is a result of pathology in the signal and information process in the cell. The changes in gene expression without any changes in the DNA sequence (epigenetic) as well as the divine genetic engineering functions are clear proof demonstrating that every single action in the cell occurs with a certain aim that is based on knowledge and calculations.

Hamza Aydin holds a PhD in biology.

References

• Shapiro J. A.(2001). “Genome Formatting for Computation and Function: Genome Organization and Reorganization in Evolution: Formatting for Computation and Function.” Presented at the “Contextualizing the Genome” symposium, Ghent University, Belgium, November 25–28, 2001 (Ann. N.Y. Acad. Sci., in press).
• –. (2005). “A 21st century view of evolution: genome system architecture, repetitive DNA, and natural genetic engineering.” Gene 345 (2005) pp. 91–100.
• Shapiro J. A. and Sternberg R V (2005). “Why repetitive DNA is essential to genome function.” Biol. Rev. (2005), 80, pp. 1–24. Cambridge Philosophical Society. DOI: 10.1017/S1464793104006657.

Globalization or Westernization?

As the mere terminology surrounding the debate has led to a considerable amount of confusion and misunderstanding, we need to define our terms. Globalization is the spread and exchange of people, goods, and ideas across the globe. Characteristically, it is directly associated with change, or transformation, modernity, and an increasingly interdependent relationship between different regions of the world. “Globalization is an aspect of human life that has always been there since the beginning of humanity. It corresponds with the natural human instinct and man’s tendency towards being a ‘social animal.’ It is the tendency with which God has created man to live on exchanging his sources and experiences with others around him, in order to achieve and realize the best chances of life.” (1)

However, globalization is frequently associated with the liberal classical economic theory, and since the mid-1970s with neo-liberalism, which has its roots in the classical economic theory. More specifically, globalization is considered a reflection of the classical economic theory’s principle of comparative advantage, which promotes an open economic system and free trade in order to achieve and realize the best chances of life.

Although the process of globalization has been linked with concepts of comparative advantage, free trade, and open economy, its origins can be traced to a time long before such ideas appeared. In order to develop a more comprehensive and accurate understanding of the so called “Islam-globalization” debate, it is critical to distinguish between the process of globalization in its original sense and such relatively more contemporary processes, like Westernization, that are masked as globalization and yet are fundamentally different.

“Globalization targets the narrowing of the gaps separating different communities. This is done by exchanging benefits in all aspects of life — economic, social, scientific, and political governance. That is, they exchange information, understand each other’s values and codes of ethics and build a common ground.” (2) In contrast, Westernization does not consider such an understanding or building of such common ground to be worthwhile enterprises. Globalization is a process in which “the whole world becomes like a small village, where the less advanced communities can develop their capacities” and that “tends to be a two-way street process, which makes it possible for each community to take as well as to give.” (3) Westernization, on the other hand, tends to be a one-way street, meaning that one region attempts to dominate and control other regions in the name of globalization. Moreover, while globalization occurs through the free will of different communities, Westernization is characteristically imposed upon other regions.

Islam’s role

Having clarified the difference between globalization and Westernization, the Islam-globalization debate can be assessed more accurately. Islam is not anti-globalization (or modernity, which is considered to be a by-product of globalization) in its original sense, but Muslims do have a problem with Westernization. “Although Westernization of society is condemned, modernization as such is not. Science and technology are accepted, but they are to be subordinated to Islamic belief and values in order to guard against the Westernization and secularization of Muslim society.” (4) Based upon historical precedence and contemporary evidence, Islam clearly embraces globalization in its original form, which is based upon free-will and not upon the aggressive imposition of the West upon the East.

First of all, it is important to note that Islam orders people to cooperate, to be helpful to one another according to goodness and piety, and not to be helpful in evil and malice (Qur’an 5:2). This principle is fully endorsed by Prophet Muhammad on the local level, regardless if your neighbor is a Muslim or not. Surely this principle can be extended into the international level, where a neighboring country can be defined as any country that has normal economic and political relations with the Islamic world.(5)

Other factors illustrate Islam’s acceptance and predominant role in the process of globalization. “For several centuries, Arabic was the world’s leading language in sciences. Muslims made important advances in mathematics, astronomy and medicine — a legacy from which European scholars derived great benefit,” and which led to the Renaissance. (6) Globalization is not only a Western phenomenon, for “the agents of globalization are neither European nor exclusively Western, nor are they necessarily linked to Western dominance. Indeed, Europe would have been a lot poorer — economically, culturally, and scientifically — had it resisted the globalization of mathematics, science, and technology [from the East]…”(7)

We have to differentiate between the gifts of globalization and the products of Westernization. More specifically, the Islam-globalization debate in itself is built upon a number of mistaken diagnoses that misconstrue Islam’s place in the globalized world — one that has been quite productive in the past and has the potential to be productive in the future. The misguided assumption that Islam opposes globalization and modernization is dangerous, because it could potentially result in the loss of Islam’s significant contributions to the rest of the world.

Muslim attitudes toward Westernization

The Muslim world’s reaction to Westernization, and the West’s emergence as the dominant force transforming the world, must be assessed. “It is similar to the emergence of the Arab Muslims as a major world power in the seventh and eighth centuries…”(8) It is important to note that “the Muslim weakness at the end of the eighteenth century coincided with the rise of an entirely different type of civilization in the West, and this time the Muslim world would find it far more difficult to meet the challenge.”(9) In the past, Muslim communities were able to revitalize Islam’s role and power in the world. However, the impact of Westernization was an unprecedented experience that significantly challenged Islam and created a bi-polar dichotomy that separated the West from the rest — and specifically from Islam.

From a historical perspective, Westernization minimized Islam’s role and made it dependent upon the Western way of doing things. “The Islamic world has been convulsed by the modernization process. Instead of being one of the leaders of world civilization, Islamdom was quickly and permanently reduced to a dependent bloc by European powers.”(10) As a result, resentment toward the West emerged. Muslims questioned whether they would have to accept Western-style modernization or be deemed as being anti-globalization. “From this point, a growing number of Muslims would wrestle with these questions, and their attempts to put Muslim history back on the straight path would sometimes appear desperate and even despairing. The suicide bomber — an almost unparalleled phenomenon in Islamic history — shows that some Muslims are convinced that they are pitted against hopeless odds.”(11)

The emergence and rise of extremism can be directly attributed to the resulting resentment toward the Western style of globalization — a one-way process that does not strive to create a common ground between the West and other regions, and hence the desire and perceived need to pursue religious revivalism. However, we should realize that violence and extremism are not exclusively Islamic phenomena. “The Western media often gives the impression that the embattled and occasionally violent form of religiosity known as fundamentalism is a purely Islamic phenomenon. This is not the case. Fundamentalism is a global fact and has surfaced in every major faith in response to the problems of our modernity.”(12)

“For Islamic society, the underlying concerns regarding globalization are: how to protect a unique heritage in the face of global pressure; to uphold religious traditions; to preserve linguistic purity; to defend social institutions; and ultimately, to maintain a viable identity in the midst of a rapidly changing global environment.”(13) According to Islam, complete submission to God is the first and foremost priority for all Muslims. Anything that undermines Islamic principles is considered a threat to Islam’s longevity and power in the world. More importantly, we should be aware of the fact that despite the Islam-West bi-polarization, Islam is rapidly becoming a global phenomenon that transcends the boundaries that once separated the West from the rest.

Global Islam: The growing phenomenon and implications for the future

Islam is the second largest religion and the fastest growing religion in the world. Islam began to spread in Arabia around the year 610 A.D. when Prophet Muhammad began receiving revelations from God through Archangel Gabriel, sharing with others what he had been told. Today, Islam is a global phenomenon represented by Muslims across the world. “Fifteen million Muslims reside in Europe, and seven to eight million in the United States. There are now about a thousand mosques each in Germany and France, and five hundred in the United Kingdom.”(14) One factor that may explain the rapid spread of Islam is the process of globalization itself.

Islam’s future depends upon its ability to wed Western-style modernism with Islamic principles, or, in other words, whether it can develop an Islamic-style modernism. The challenge is to engage in modernity without sacrificing Muslim values or undermining Islamic principles. “As we are only slowly realizing, Islam is truly a world religion, increasingly visible in Europe and the United States as well as Asia, Africa, and the Middle East.”(15) It is significant for the future of Islam that “the capitals and major cities of Islam are not only Cairo, Istanbul, Mecca, but equally Paris, London, New York.”(16)

Given that Islam has become a global phenomenon, it is increasingly important that its principles are respected and not made irrelevant in the modern world. “All religious people in any age have to make their traditions address the challenge of their particular modernity…”(17) Rather than provoking the bi-polarization of the world, separating Islamic values from Western values, the goal of globalization is to develop an understanding of each other’s values and codes of ethics and to establish a common ground. Establishing a common ground is vital for ensuring the progress of globalization and allowing the world to reach its full potential. Modernization and globalization need to respect the identities of all regions and respect religion as a natural necessity for humanity.

Conclusion

The struggle for religion to remain relevant in the world is common to all religions at some point in history. Much of the literature surrounding the current Islam-globalization debate provides an inadequate and fragmented view of religion’s role in the process of globalization. Secularization, which is promoted in the current forms of globalization, is a new concept. In fact, based upon historical precedence, religion has played a key role in contributing to globalization and, more specifically, Islam has had a predominant role. The challenge for the future of a globalized world, and not just for Islam, is to be helpful to one another according to goodness and piety, and not to be helpful in evil and malice (Qur’an 5:2).

This article is available in Romanian in the following link: http://webhostinggeeks.com/science/article-fountainmagazine-rm

Footnotes

1. www.IslamOnline.com.
2. www.IslamOnline.com.
3. www.IslamOnline.com.
4. John Esposito, Islam: The Straight Path, 3d ed. (Oxford University Press, 1998), 165.
5. Choudhury, www.Islamic-finance.net.
6. Hardy, http://news.bbc.co.uk.
7. Sen, www.prospect.org.
8. Karen Armstrong, Islam: A Short History, (Modern Library: 2002), 141.
9. Ibid., 138.
10. Ibid.,
11. 146.
12. Ibid., 153.
13. Ibid., 164.
14. Dr. Ahmed Kamal Aboulmagd, The Middle East Times,
15. Armstrong, Islam, 176.
16. Esposito, Islam, xvi.
17. Ibid, 203.
18. Armstrong, Islam, 164.