Beginning in July of 2019, the Brazilian Amazon rainforest has been up in flames, burning up the lush foliage and engulfing much of the wildlife, along with many Indigenous groups, in its fiery wake. Yet, it’s receiving little to no media coverage due to the global community’s seemingly unconcerned liability to take action. Greenpeace, the international environmental organization, is holding Brazil’s current government under President Jair Bolsonaro responsible as the primary cause of the fires due to negligence. They claim that mass deforestation has been taking place at an increasingly alarming rate, especially following Bolsonaro’s election, and farming and ranching that have also been taking place in surrounding areas have been contributing to the rise in destruction as well (Greenpeace 2019) [1]. These problems have not been addressed in a timely manner.

Various ideologies, such as Dualism, have been heavily promoted within the past few centuries have also shifted humanity’s conscious to one that is less ecologically friendly and more materially greedy. Without help from the international community and the government of Brazil, the Amazon will continue to be subjected to destruction [1].

The Amazon is a massive area, covering roughly 2,300,000 square miles of South American land. It is one of the most important and critical components of the Earth’s delicate ecological balance and to date 2,240,000 acres have been burned due to the 2019 wildfires (in addition to the great amount of damage that has already been done). It is responsible for atmospheric oxygen composition and cleanliness, maintaining the atmosphere’s water cycle, and for the preservation of many rare animal and plant species. Much of the vegetation in the Amazon also includes important medicinal plant species that can be used to cure a multitude of illnesses and diseases [7].

Deforestation, which has plagued the Brazilian Amazon for decades now, is utilized for the establishment of farms and ranches, which has tripled the number of cattle present in this area and surrounding regions (Dwyer 2019) [2]. Farming and ranching have caused more pollution and the poisoning of, not only the lands in these areas, but the entire well-being of our Earth and atmosphere as a whole. Production of methane from cattle and other pollutants are consequential of farming and ranching, and contribute greatly to fire susceptibility of the Amazon. The fires have spiked in these areas where deforestation and pollution are at their peaks (Dwyer 2019) [2]. When it comes down to it, the Brazilian government, in general, expresses lesser concern, even though they make it apparent that they “may look into measures to combat these fires” (Greenpeace 2019) [1], it seems politics is snaking its way into crisis affairs and impeding them once again instead of acting upon them with optimism. [2]

In the past, Brazil was much more involved in helping to prevent deforestation in both public and private lands of the forests. In 2006, the government passed the Public Forest Management law. This law established concessions and funding for forest conservation and regulations involving deforestation in public areas of the forest. Other organizations and institutions that were established following this law being passed included CONAFLOR (a civil society forestry board), IMAZON (an NGO that monitors deforestation), FUNBIO (an environmental fund that budgets financing towards protected lands and biodiversity), INPE (a Brazilian space observation company that also monitors deforestation), and lastly IPAM, a governmental research institution that focuses on deforestation, climate change, and natural resources in respect to the Brazilian environment (Yale 2019) [10]. Indigenous individuals and tribes within the Amazon, along with private property owners, have also gone to great lengths to prevent deforestation and have made the most difference and impact in doing so (Yale 2019) [10]. It was ultimately a grassroots movement of people standing shoulder-to-shoulder, and not a specific government agency, that was able to make the most progress to preserve much of the Amazon’s beauty and help stave off deforestation [5].

Despite the efforts that have been exerted into the establishment of laws, policies, and government organizations in order to protect the Amazon, protection of the Amazon has been much neglected for now and for future generations. Other countries, such as the United States and the United Kingdom, also believe that Brazil is not doing enough. But, President Bolsonaro seems to have many political reasons to continue to resist international help to halt the fires and stop deforestation. His outspokenness of his pro-deforestation views has ignited a wave of eager ranchers and farmers to continue, and even escalate, their destruction of the Amazon (Specht, 2019) [9].

Religion and environment

As for religious and spiritual views of the environment, some people have manipulated various religious teachings to promote negative ideologies and views of the environment rather than positive ones. These ideologies argue that all animal and natural life was created to serve mankind, and that humanity has no responsibility to take care of our planet or maintain a balance of life in the natural world. The Indigenous people of the Amazon, such as the Xingu tribe, view these perspectives as “predatory” and are in fear that everything they know and love will be taken away from them due to the utter destruction, negligence and lack of aide provided by the government. Many leaders of these tribes call these events the “destruction of Mother Earth” and the fires that have been set ablaze are Mother Nature’s calls for help (Johnson 2019) [5]. To provide more of a visual, there are roughly 817,000 individuals in Brazil who self-report themselves as indigenous, and there are 67 known tribes within Brazil that do not have contact with the outside world as of now. The Amazon serves as these tribes’ livelihood. Many individuals who are a part of these tribes were born in the rainforest, grew up in the rainforest, hunt in these forests, and make their living in these forests; Amazon is all they know and love [5].

In an article titled “Dualisms – Environmental Humanities”, Dualism is outlined as one entity being viewed as “genuine and superior” while all other life is categorized as “other”. This concept has had major impacts on the way we as humans view the products of our environment. Dualism fuels the idea that the environment, and all non-human living beings within it, are put on this Earth specifically to serve us as humans and us alone. This ideology allows people to infer that there is a distinct separation between humans and every other living being on the planet, and that these distinctions make it possible for humans to justify destructive actions towards the environment. In addition to these ideas, the concept of “ecological consciousness” is found to play an important role in the relationship between religion and in being mindful of our consumption of our environmental resources, as we continue to consume them faster than they can regenerate themselves (Andrew 2019) [3].

Christianity and Islam are two religions that promote ecological consciousness and believe that the Earth’s resources should be treasured and treated with respect. This places a strong emphasis on environmental protection and environmental rights, which thus encourages followers and believers of the religion to do the same. Religion provides us with morals and values that can be adopted when it comes to our views of all other living things whom also share this Earth with us; not only our views of these beings, but how we treat these beings as well. Finally, Christianity and Islam argue that “being a servant of God” also encompasses the idea that Man must protect what God has entrusted him with, the environment included (Pahl 2018). Specifically in regards to Islamic views, Tawhid, meaning the “oneness of God”, is a critical component that Islam bases itself upon. The religion of Islam, like Christianity and Judaism, is a monotheistic religion, meaning that these religions base their values and morals on the belief that there is only one God. All existence, including the human beings, are His creation, and in that sense they are part of the one same whole and exist interdependently [4][9].

Despite the disregard of public outcries, there are ways that everyday individuals, such as ourselves, may combat this issue head on and on our own without aide from government agencies. Our first mission should be to make this issue as public as possible. Share as much reliable news coverage as you possibly can and spread the word as far as it will go. If you are able, donate to wildlife conservation and forestation projects held locally or online. Spread knowledge and education. Call attention to higher powers. Other ways in which the everyday community can make a difference include supporting Indigenous groups and tribes residing in the Amazon; begin developing an allyship by using less paper and wood products, by consuming more ethically sourced foods, by voting, and by challenging large corporations who are impeding on the health improvement of the Amazon [8].

Let’s take action! The Amazon, its people, and its wildlife need the world’s cooperation, or they do not stand a chance against the ravenous gluttony that is deforestation. We can save the lungs of our Earth together.

References

1. Amazon Rainforest. (n.d.). Retrieved August 22, 2019, from https://www.greenpeace.org/usa/forests/amazon-rainforest/
2. Dwyer, C. (2019, August 21). Tens of Thousands of Fires Ravage Brazilian Amazon, Where Deforestation Has Spiked. Retrieved August 22, 2019, from https://www.npr.org/2019/08/21/753140642/tens-of-thousands-of-fires-ravage-brazilian-amazon-where-deforestation-has-spikeA.
3. UNSW Australia 2016. “Dualisms – Environmental Humanities.” FutureLearn, www.futurelearn.com/courses/remaking-nature/0/steps/57394.
4. Pahl, Justin. 2019. “Nature and Environment in Contemporary Religious Contexts.” The Fountain. Retrieved August 29, 2019 (https://fountainmagazine.com/2018/issue-126-november-december-2018/nature-and-environment-in-contemporary-religious-contexts).
5. Johnson, Jake. 2019. “Indigenous Tribes on Front Line of Amazon Rainforest Fires Vow To Resist Bolsonaro’s ‘Destruction of Mother Nature.’” Common Dreams. Retrieved (https://www.commondreams.org/news/2019/08/27/indigenous-tribes-front-line-amazon-rainforest-fires-vow-resist-bolsonaros).
6. Saving the Rainforests. (n.d.). Retrieved October 16, 2019, from http://www.srl.caltech.edu/personnel/krubal/rainforest/Edit560s6/www/preserve.html.
7. Kessler, Robert. 2019. “The Amazon Is Burning.” EcoHealth Alliance. Retrieved October 18, 2019 (https://www.ecohealthalliance.org/2019/08/the-amazon-is-burning?gclid=EAIaIQobChMI59uAtoKm5QIVCNRkCh0_eAvsEAAYASAAEgI_q_D_BwE).
8. Specht, Doug. n.d. “Amazon Fires: 8 Ways You Can Help Stop the Rainforest Burning.” Public Radio International. Retrieved October 18, 2019 (https://www.pri.org/stories/2019-08-29/amazon-fires-8-ways-you-can-help-stop-rainforest-burning)
9. “Quick Links.” IslamiCity. Retrieved October 18, 2019 (https://www.islamicity.org/topics/tawhid-oneness-of-god/).
10. Yale University. (n.d.). Retrieved October 27, 2019, from https://globalforestatlas.yale.edu/amazon/forest-governance/brazil.

Heart Failure

The heart is basically a pump that provides the force needed to circulate blood and its contents to the body. It consists of four chambers: left ventricle, left atrium, right ventricle, and right atrium. The right ventricle and atrium collect the blood from the whole body and pump it to the lungs for removal of carbon dioxide and replenishment of oxygen. On the other hand, the left ventricle and atrium are responsible for collecting the blood from the lungs and pumping it to the body through the aorta (main artery). Non-stop blood circulation requires life-long and unfailing heart muscle power. Common symptoms of heart failure include waking up at the middle of night with shortness of breath and decreased ability to walk a few steps upstairs. Heart failure could arise due to any condition that decreases efficiency of the myocardium (heart muscle – Figure 1) through myocardial infarctions (death of muscles due to lack of oxygen, also known as heart attack) or overloading, such as hypertension, that requires increased contraction force. Loss of function in the ventricles (lower chamber of the heart) may require the use of ventricular assist devices (VAD).

Ventricular assist devices

A VAD is a mechanical pump that is implanted into the chest of patients to support the heart function through bridging the blood flow from the lower chamber to the aorta (Figure 2).^2,3 A VAD is usually useful during or after cardiac surgeries until recovery of the heart or while waiting for a heart transplant. VADs could also be used long term if the patient is not eligible for a heart transplant due to other complications. A VAD has several components, including a tube carrying blood out of the heart into a pump, a pump with another tube carrying blood to the aorta, and a power supply connecting to a control unit that monitors the VAD`s functionality.

There are different designs of VADs such as HeartMate, HeartWare, DuraHeart, and so on. Some VADs pump like the heart does, using a pumping action, and others use continuous blood flow. Intriguingly, VADs with continuous flow lead to a loss of normal pulse, but this has been found to decrease complications and increase survival. Two types of VADs include left ventricular assist device (LVAD) or right VAD (RVAD). LVADs are the most commonly used ones due to higher incidence of left ventricular function loss. If both LVAD and RVADs are used together, they are called a biventricular assist device (BVAC). VADs nowadays could be used not only for people with end stage heart failure, but also earlier stages of heart failure, including children. A VAD takes ninety percent of the pumping function of the heart. When using a VAD, your heart will still beat and have a rhythm. If none of these works for a patient, this requires the use of a mechanical or artificial heart, also known as total artificial heart (TAH).

Total artificial hearts

An artificial heart is a mechanical device that substitutes for the failing heart.^4,5,6 They are commonly used during heart transplantations to bridge the blood flow temporarily or to replace the heart permanently during a shortage of transplantable hearts. Early studies with artificial heart trials go back to the 1940s. Since then, various groups worldwide have invested in development of artificial heart prototypes and performed animal and human trials. Total artificial heart prototypes include, but are not limited to, SynCardia, ABIOMed (AbioCor), and Carpentier (CARMAT).6

SynCardia is developed from the Jarvik-7. It was first implanted in 1982. Dr. Robert Jarvik originally designed the Jarvik-7 (Figure 3). Barney Clark underwent the first artificial heart implantation at the University of Utah and survived for 112 days. This was followed by other implants. The longest survival with the Jarvik-7 is 620 days. However, the device is more commonly used on patients as a bridge during heart transplants. It has two pumps that resemble the two ventricles of the heart and is pneumatically (air) powered. The pump of SynCardia is covered with polyurethane. A pneumatic driver used in the US is a non-portable console, and requires patients to stay in the hospital. However, a portable version has been developed in Europe that could be carried a backpack while a patient waits for a donor heart.

The ABIOMed (AbioCor) is a completely self-contained, total artificial heart, which avoids the need for an external console or having wires or tubes piercing the skin to power the device. It uses a wireless energy transfer system, also known as a transcutaneous energy transmission system. This decreases the risk of developing infections due to implants.

CARMAT, on the other hand, is designed by Alain F. Carpentier.⁷ It is a fully implantable artificial heart with embedded biomaterials that make the device more biocompatible. In addition, the CARMAT includes valves made from cow heart tissue and has internal pressure sensors. This allows a person to adjust the flow rate in response to increased demand, such as during exercise. This feature distinguishes the CARMAT from other artificial hearts that provides a constant flow rate.

Biological artificial hearts

Synthetic replacement of organs is one of the long-sought dreams of modern medicine. To this end, there are efforts to develop biological artificial hearts in the laboratory. One recent study took the approach of producing a decellurized (empty from cells) scaffold of a mouse heart and recellurized it with human cardiac cells, and showed that lab-grown human heart tissue can beat on its own (about 40-50 beats per minute) in as short as a few weeks (Figure 4).⁸ They took the advantage of induced pluripotent cell (iPS cells) technology to produce multi-potential cardiovascular progenitor (MCP) cells, which could give rise to all three types of cardiac cells found in the heart. This area of research is still in its infancy but in the future, at least, it may provide tools to generate patches of heart tissue to replace damaged parts of the hearts. Given the success of a mouse heart cellurized with human cardiac cells, it’s possible that scientists will also try to decellurize the heart of a monkey or another animal and then cellurize it with human cardiac cells to produce a beating human heart in the laboratory as an alternative source to a full heart transplant.

Another approach to a biological artificial heart is to genetically modify animals in a way that their hearts will be compatible with a human body. Genetic engineering is a rapidly evolving field that one day could provide such tools for scientist to grow necessary organs in monkeys, dogs, or maybe even horses. Genetic modification may overcome tissue rejection issues when they are transplanted into a human body. For instance, one study tested the possibility of a heart transplant from genetically modified pigs into monkeys and showed the applicability of heart transplants between different species.^9,10

Until the development of biological artificial hearts, ventricular assist devices and mechanical artificial hearts seem to the best options. However, artificial heart implants have had various complications, including infections, pneumonia, high fevers, and multiple organ failures with variable survival rates based on the type of device and materials used. Another issue is the necessity of artificial heart to meet requirements of the body in terms of heart flow rate. For instance, the required flow rate of someone walking or exercising is different than someone at rest. In addition, the possibility of mechanical or computerized systems to fail may be a source of distress in patients implanted with artificial hearts or assist devices. This reminds us of that as long as we take care of our heart’s health, we won’t have worry whether its battery could fail – and what a mercy that is.

It is stunning that even with so much need and effort we are still not able to develop something that completely replaces all the functions of a heart. This clearly points that the heart is a marvelous gift granted to us. We are counting on every beat of the heart for our survival, and we should give thanks, with every beat, for what an incredible gift we’ve been given.

References

1. Bui, A. L., Horwich, T. B. & Fonarow, G. C. Epidemiology and risk profile of heart failure. Nat Rev Cardiol 8, 30-41 (2010).

2. What Is a Ventricular Assist Device? NHLBI, NIH. Retrieved from www.nhlbi.nih.gov/health/health-topics/topics/vad/ on 1/2/14.

3. Ventricular assist devices (VADs) Definition – Tests and Procedures – Mayo Clinic. Retrieved from www.mayoclinic.org/tests-procedures/ventricular-assist-devices/basics/definition/PRC-20020578 on 1/2/14.

4. Artificial Hearts. Retrived from www.umasswiki.com/wiki/Artificial_Hearts on 1/2/14.

5. Artificial heart. Retrieved from en.wikipedia.org/wiki/Artificial_heart on 1/2/14.

6. Heart Assist Devices. Texas Heart Institute. Retrieved from http://texasheart.org/Research/Devices/index.cfm on 1/12/14

7. Carmat artificial heart patient in good condition: hospital. Retrieved from www.reuters.com/article/2013/12/30/us-carmat-patient-idUSBRE9BS07O20131230 on 1/2/14.

8. Lu, Tung-Ying, Bo Lin, Jong Kim, Mara Sullivan, Kimimasa Tobita, Guy Salama, and Lei Yang. “Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells.” Nature communications 4 (2013).

9. Heart of genetically modified pig ‘successfully transplanted into monkey’, South Korea scientists claim. Retrieved from http://www.dailymail.co.uk/news/article-2164964/South-Korea-scientists-successfully-transplant-heart-genetically-modified-pig-monkey.html on 12/1/14

10. Pig to human transplants. Retrieved from http://www.theguardian.com/world/2002/jan/03/qanda.simonjeffery on 12/1/14

Humps store fat and also protect camels’ other tissues from heating due to sun light. It has also been reported that camels’ coats insulate them from heat by reflecting sunlight. This extra fat tissue (about 10-15 kg) provides not only energy in long desert journeys but also water through a biochemical process which leads to the production water molecules (1,111 g of water per 1,000 g of fat converted). It is also noteworthy that sparing a specific part of the body for storing fat and refraining from storage in other tissues provides decreased fat density, thus lessening heat retention due to fat.

Water is scarce in the desert and needs to be stored in large amounts when available. Amazingly, camels can drink up to 150-200 liters of water at once, and yet, after three days, there is no sign of water in their stomachs. Drinking so much water in such a short time could be a problem; this would be like a human drinking 20-40 liters of water in 10 minutes, which would induce water intoxication. The oval shape of camel’s red blood cells, and their ability to swell until double in volume provides plasticity in this situation.

Camels can lose up to 25% of their bodily fluids without showing signs of dehydration. This provides an extra durability against long-term water shortage. For comparison, most mammals can only withstand about 3-4% dehydration; further water loss might lead to cardiac failure due to thickened blood. Another protective property given to camels that allows decreased water loss is that they drop feces that are so dry they can be used as a fuel. For comparison, a dromedary camel loses 2.5 liters of water daily through feces (about just 40-60% water) while cattle lose 20-40 liters.

Camels also regulate sweating in a unique way. Their body temperature does not need to be constant; it can move between 34 and 41 degrees centigrade. They don’t sweat until it is over 40 degrees. These regulations allow them to preserve approximately 5 liters of water per day. A camel’s kidney function is also tightly regulated according to the availability of water. If they don’t drink water for days, urine production is limited to approximately 500g. On the other hand, if water is abundant it could go up to 7 liters. This urine is unusually thick, too – it resembles syrup. Remarkably, camels never run, which would increase transpiration; instead they just amble quickly.

However, dehydration can be still an issue, which will negatively affect the flow of red blood cells. Remarkably, camels have oval red blood cells, which better resist clumping when compared to round, human red blood cells. There are no other mammals with oval red blood cells.

Food is another problem for animals living in the desert, especially for big ones like camels. Interestingly, camels have split lips, which allow them to graze easily. They can eat thorny twigs without any injury. Eating green plants also provide the moisture that they need.

Sand is often a problem, especially during sand storms. Remarkably, camels are equipped with systems that allow them to close theirs nostrils to get protection against wind and sand. In addition, camels have two layers of thick eyelashes, which provide additional protection from the dust. The specific shape of their nostrils allows them to preserve vapor and allows returning it to the body.

Traveling over sand is difficult. Camels are created in a way that allows their four legs to kick in all directions. Remarkably, Camels are equipped with paddy hoofs and two toes to protect them from sinking in the sand and burning of the hot sand. In addition, they have long legs, which keep them further from the hot ground.

Though the modern world seems to have replaced them as a major mode of transportation, they are still widely used in areas such as North Africa.

It seems likely many more remarkable discoveries about camels are on the horizon. Medical researchers are studying how camels function – because these amazing animals might contain a secret which could save human lives.

Link between excess body fat and cancer

It is obvious that camels undergo a rapid cycle of fat storage and destruction. They store large amounts of fat – up to 15 kg. The correlation between excess body fat and various cancers in humans has long been known. For instance, a WCRF report recommended maintaining a BMI of 20-25%, and claimed it as one of the key factors can prevent cancer. However, a connection between obesity and cancer at the molecular level remains largely unknown. Intriguingly, a recent study performed at UT Southwestern Medical Center by Dr. Scherer and his colleagues shows how fat cells induce cancer cells to thrive in the breast, or fatty livers.

They showed that fat cells allow the growth of tumors via the secretion of a variety of extracellular factors. One of the fat cells derived extracellular factor, which is found abundantly in unhealthy fat tissue, is endotrophin. What endotrophin does is cause induction of blood vessels, which feeds tumors; as we gain weight, this increases the chance of getting cancer. The inhibition of endotrophin by antibodies in mice with breast cancer had a remarkable reduction on tumor growth and prevented metastasis to other tissues.

Well, if fat is bad and could increase the chance of cancer, and camels store and destroy fat as a survival mechanism, then how do camels manage the increased risk of cancer? Do they also have another remarkable property that lies on the horizon to be discovered? It’s probable there is a mechanism in camels that protects them from such adverse effects of excess fat. If so, how can we benefit from it to solve one of the biggest hurdles to human health? Some researchers might be close to answering these questions.

Antineoplastons

An interesting study, started back in 1967 by Dr. Burzynski and colleagues, examined the peptides in the urine samples of healthy and cancerous patients. They have found that cancer patients lacked a significant content of peptides in their urine. This finding led to the hypothesis that there might be a protective mechanism against the formation of cancer in the body through peptides. They identified a specific group of peptides found in the urine, later named Antineoplastons that show anti-cancer properties. A treatment scheme was developed through balancing the antineoplaston deficiency in cancer patients to control the abnormal cellular growth. They have tested both in laboratory and on the various cancer patients, and demonstrated some degree of response, albeit with excessive criticism from the scientific community. The mechanism of action of antineoplaston is proposed as functioning as a molecular switch; this activates tumor suppressors and inactivates oncogenes (drivers of cancer formation). Dr. Burzynski, in his clinic at Houston, TX, is still providing treatments to cancer patients with late stages of cancer using Antineoplastons, and claiming that there are survivals with his approach.

The use of compounds identified in the urine could be considered as a kind of urine therapy, which is used as an alternative treatment to cancer that has been historically practiced for different purposes. This reminds me of the prescription of some Bedouins, who got sick when they came to city. They suggested drinking the milk and urine of freely grazing camels at the city’s outskirts. It has been said that they drank this concoction and grew healthy again. This incidence and historical use of urine therapy suggests that camel’s milk and urine could have unique substances that might be effective in the treatment of diseases, maybe even of cancer. An interesting point here is that the Prophet Muhammad, peace be upon him, specifically ordered to drink from animals that are freely gazing, which is also mentioned in the Qur’an, such as in the miracle of the Prophet Salih with the she-camel about which his community was tried: “[S]o leave her to feed in God’s earth” (11:64). This points to not only the consumption of products from freely grazing animals, which is known to affect their nutrition levels and taste, but also to their increased therapeutic potential.

The Holy Qur’an calls for reflection on the camel specifically. I am little bit disappointed that the Houston Zoo does not have such a monumental animal. Contemplation on the camel provides various lessons on the understanding the Maker and Owner of the worlds and living beings, and the superior techniques used in the makeup of animals that live in the harsh conditions of deserts.

References

• 10 Amazing Facts About Camels. Retrieved from http://news.softpedia.com/news/10-Amazing-Facts-About-Camels-68843.shtml on April, 14, 2013.

• 20 Amazing Facts About Camels. Retrieved from http://www.environmentalgraffiti.com/news-expressive-faces-camels?image=1#mzJyLiKcQPMoM1tD.99 on April, 14, 2013.

• Facts About Camels. Retrieved from http://lifestyle.iloveindia.com/lounge/facts-about-camels-1654.html on April, 14, 2013.

• Camel. Retrieved from http://en.wikipedia.org/wiki/Camel on April, 14, 2013.

• Excess Body Fat Causes Cancer. • The WCRF report, 2007. Retrieved from http://www.medicalnewstoday.com/releases/87350.php on April, 21, 2013.

• Finding – and fighting – the fat that fuels cancer. Retrieved from http://www.utsouthwestern.edu/newsroom/news-releases/year-2013/feb/endotrophin-scherer.html on April, 21, 2013.

• Jiyoung Park and Philipp E. Scherer. Adipocyte-derived endotrophin promotes malignant tumor progression. J Clin Invest. 2012;122(11):4243–4256. doi:10.1172/JCI63930.

• Stanislaw R. Burzynski. The present state of antineoplaston research. Integr Cancer Ther. 2004 Mar;3(1):47-58.

• Urine Therapy. Retrieved from http://en.wikipedia.org/wiki/Urine_therapy on April 22, 2013.

• Ravi: Enes. Tirmizi, Tibb 6, (2043)

Adam forgot, so did his children.

How does our brain store information? How is it possible to make learning faster and easier? Is there any way not to forget what we have learned and to remember things more easily? Of what importance is the fact that information is never deleted from our memory, even if we have forgotten it? These are among many of the questions for which answers have been sought over the years.

Memory is one of the functions of the brain and it is defined as the ability to preserve acquired information consciously and relate it to the past. It is not just a certain portion of the brain, but rather the entire organ that functions in storing, processing, and retrieving external and internal signals. Signals that build up our memory are what we usually perceive through our five senses. When we burn our hand, or see or experience a traffic accident , when we are given a compliment and many other events are all examples of external signals, whereas internal signals are related to our nervous system or imagination. The pain one feels during a heart attack, the anxiety of a cold sweat, or a beautiful daydream are all stored in our memory too. We may or may not remember them. There is no deletion; it is simply that we do not remember. Forgetting is a state that is encoded in our makeup with differing degrees, depending on the kind of life the person has experienced. Age, gender, stress, habits, and illnesses all have varying roles in forgetting.

Short-term memory

Short-term memory refers to saving and remembering what we have learned a few seconds or minutes ago; the prefrontal brain is the location for this temporary processing. Signals are kept in this portion of the brain for a few seconds and then conveyed to the back stage (as in the transfer of data from the cache memory to the main memory in computers). We tend to quickly forget those things on which we have not spent a long time or to which we have not assigned great importance, even though we can understand them. Imagine how unbearable our life would be if we were to store in our memories and remember things in infinite detail like the color of the wall we are facing, the variety of the objects around us and their qualities, the air we breathe in and out, or every beat of our heart. The signals that come to our brain within a certain time frame are filtered according to our needs and their significance and limitations are applied depending on their qualities and quantities.

There is no consolidation processing for short term memory. Second or minutes after signals are received they are retrieved in accordance with what we need; if they are insignificant for us, they are forgotten in the same amount of time. The information that is significant for the person is consolidated in the hippocampus and reserved in mid and long-term memory units.

Mid and long term memory

After being processed in the sub-cortex (limbic system) of the brain, signals are saved. Depending on their level of urgency, the meaning they stand for, and their emotional effect, signals are saved in either the mid or long term memory. Pain, joy, pleasure, and fear are states that solidify memory traces. A heart attack, the infliction of wounds and bruises or humiliation, accidents, visits from a loved one-these are all examples of events that are easily remembered. However, a lasting record is almost impossible to attain if the subject is something that has been forced (like a student studying for higher marks) or if the subject does not appeal at all. Consolidation is necessary to make a short term memory a lasting one. However, if a student is curious about the subject and enjoys what he or she is learning, then long term memory is possible without too much effort in consolidation. Forced consolidation (e.g. a student’s orientation to attain higher marks) requires a longer period. The information is consolidated more easily when a person is in a sound and alert state of mind.

Storage in the long-term memory does not occur immediately after something has been learned or experienced. For this storage to be possible at least an hour needs to pass to synthesize the memory proteins that are responsible for recording. If electric shock is applied to a person’s brain immediately after an unforgettable event, they will not be able to remember the event. But if the electric shock is applied an hour later, the memory remains.

Once stored in long-term memory, information can be retrieved, even after months or years. When new information is obtained older information is called up and they are saved with a new pattern of storage, with the newcomers being related with the ones that have already been stored; it is in this way that long term memory is generated.

It has been argued that RNA has a role in storing old information. In experiments, guinea pigs were taught information through repeated practice which is stored in their long term memory. The brains of these animals were later minced up and fed to other animals. It was observed that those animals which had been fed the brains learned faster and more easily than other animals that had been fed on a diet that did not include the brains. This shows us that information encoded in the memory is not lost; rather it is transferred with the help of certain molecules. It is also known that DNA is related to genetic memory.

It has been found that people with good memories have a greater number of nerve cells and channels of transfer in the memory-related zones of their brains (cortex, corpus callosum, hippocampus, thalamus, hypothalamus, limbic system, amygdale, temporal lobe, and prefrontal cortex), while there are less cells in other zones of the brain. Nerve cells are stimulated while signals are stored in one’s memory. Even if a person has a weak memory, activities like reading, memorization, or other engagements that improve love, happiness, and peace of mind may help long-term memory.

Forgetfulness

It is important to find out whether forgetfulness occurs because of an illness or something else. Age is one major factor. Forgetfulness in an aging person is proportionate to the number of the loss of cells.

Stress, dealing with multiple things all at once, or occupying oneself with things that are of no benefit, that is, creating a pollution of information, all affect short term memory and may cause forgetfulness.

Forgetfulness due to damage or illness

If the nerve cells of the lower occipital lobe of the brain are damaged, old information cannot be retrieved. Likewise, in case of damage to the nerve cells that are found in the temporal lobes on the sides of the brain, or due to an insufficient intake of B3 and B12 vitamins, cerebral hemorrhage or an embolism in the veins of the memory zones forgetfulness may occur.

Patients with Alzheimer indicate short term memory loss. They tend to forget visitors’ names, daily events, or the doctor’s advice.

Chronic alcohol abuse may cause damage in the hippocampus and thus in the ability to encode information.

Electroshock may also delete recent information that has been recorded in the short-term memory. Thyroid failure, Parkinson’s, hydrocephaly, schizophrenia, brain tumors, and epilepsy may also cause forgetfulness.

Some advice

Spiritual teachings and religious services have many positive aspects in our lives in addition to being our duties for expressing our servanthood to God Almighty. In Islam, for instance, principles like “enjoining good and forbidding evil,” praying at night, a brief afternoon nap, staying away from what is forbidden, reading and/or memorizing the Qur’an, and other activities may provide some protection against forgetfulness.

It is also claimed that keeping oneself busy with things that are considered morally improper, not least things that are sexually provocative in an illegitimate way, may damage neurons that are operative in memory. In order to be less affected by forgetfulness in our advanced years, it can be helpful to read spiritually and intellectually useful material, to learn and memorize new words and concepts, to keep oneself in good moral condition by engaging in charity work and helping others, and to maintain good sleep and a healthy diet

On the other hand, thinking a bit more wisely, to be able to forget (not forgetfulness) also has many benefits. Our nervous system is relaxed by forgetting, otherwise it might collapse. Forgetting old informa¬tion could well open up room for new information, although this does not mean that the information is deleted from memory; it is retrieved when needed. But, if forgetting reaches a level that is above medically ex¬pected averages, then medical help should be sought.

There are incidents of patients who are suffering from dementia and Alzheimer regaining their memory after electroshock therapy. Perhaps this is evidence that we will remember and testify for all our actions when we will have to account for them.