The real, profound worth of life is revealed when one’s life is dedicated to the well-being of humanity. It thus gains an otherworldly dimension and attains a quality comparable to that of the dwellers of heaven. Centering life around such an ideal renders one’s life many times more fruitful. Those awakened souls experience such a state of rapture that it cannot be contained in a single lifetime. Then they begin to feel this cramped world as if it were but one of the spacious relieving climes of the eternal realms. Such individuals aspire to breathe life into everybody. With every revival they inspire, their hearts overflow with exuberance, as if they too are experiencing a resurrection on the path of being a life for other souls. Saving a single person is akin to saving all of humanity, says the Divine word, and this message constantly rings in the ears of their hearts.

Given that even a single human life in this transient world bears this much importance, it isn’t an exaggeration to say that an endeavor for a worldwide revival is likely to break the scales of good deeds on the Day of Judgment. With a zest for blowing life into others, a champion of revival is ever-conscious of the fact that humanity has been blessed with the best pattern of creation amongst all living creatures. These champions feel that the consciences of those who are spiritually paralyzed resemble a grim autumn scene. They are so compelled by their mission that ceasing it would qualify as a sinful act. They compose melodies of revival from the tongues of their hearts for those in spiritual death throes; they run to help these lost ones, as if running from one intensive care unit to the next.

This exhausting run is nothing to be overstated in their eyes. They spur their free will on toward the horizons of lofty ideals as being truly human necessitates. They serve as guides on this path of idealism for those who do not know the way, blow energy into those weary of walking, and become compasses for the masses who are without navigation. To those who have their backs to the sun and so keep following only their own shadow, they inspire them always to return to the source of light. These people become a support and prop for those who are weak and prone to stumble, and provide guardianship for those who are left crawling in misery from the impact of various calamities. They try to soothe sobs echoing on all sides, share the troubles of the wearied ones, forbear various separations with the resolve to keep company with the needy, and come between the growls of oppressors and groans of the oppressed. They keep running like firemen to extinguish one fire after another. As this sense of revival is preserved deep in their consciences, they strive to fulfill this spiritual endeavor in sincerity and only for Divine approval.

A person with this depth of feeling and thought brings to mind the notion of the “journey from God”; they are in a constant state of metaphysical vigilance. Their groans are their pain at how to bring happiness to others instead of themselves. They seek to effect peace in the hearts of others instead of self-indulging in the pleasures of this world. They view life always from a perspective of the sufferings and joys of others and build torches along the path of those who try to make their way through darkness. Reaching success is dependent on making others succeed; they regard indifference to laments as akin to being a mute devil and see remaining lively as conditional to blowing life into others; walkers on the path of Divine guides are their inheritors.

These actions by champions of revival yield such surprise fruits when the due time comes; they are like a kernel in the soil that flourishes into some 20-30 ears. It gives messages of being modest to hundreds of thousands of people and encourages smiles all around as hundreds of new ones have begun walking as one.

One of the processes that occurs in the body is called “inflammation.” Inflammation occurs when a cut into the skin also punctures a blood vessel. This situation directly exposes the blood to the air. Inflammation occurs in a few steps. First, the blood vessels near the wound are expanded (which causes the swelling that we see near the cut) and special proteins called “fibrins” are brought in. These fibrins bind to each other to form a net-like structure. We are all quite familiar with this net, which we call a blood clot. This net stops the bleeding and cuts the interaction between the air and the blood within a few minutes.

Next, it is time to quickly eliminate any foreign objects that got into the tissue. Special immune cells called “macrophages” are sent to the crime scene to clean up. Macrophages are large white blood cells that “eat” microbes and other foreign objects using a process called “phagocytosis.” After the scene is all cleaned up, these macrophages excrete special molecules that induce tissue repair and return the blood flow to normal. An important note here is the specific order of these events. Like every single process in the body, they occur in the most purposeful way possible. What do I mean? I mean that, first the wound is closed urgently; second, macrophages are sent in; third comes the tissue repair. Any other order would have greatly lowered the effectiveness of inflammation. Imagine that the wound is closed after the macrophages are sent in. Then, by the time the macrophages killed all the microbes, twice as many would have entered the scene. The body seems to know every single event beforehand and plans its defense accordingly.

Our body is perfectly calibrated to keep our blood, the milk of our organ systems, absolutely pristine.

Let’s say a microbe managed to sneak into the blood before inflammation occurred, and is long gone to another region of the body. Does the microbe win? Unfortunately for the microbe, it has to pass another test. This time the tester is the lymphatic system. The lymphatic system is the sewage system of the body. When the blood transfers its nutrients to the tissue, the fluid goes through the “interstitial area” (the empty space between organs). During this process, some of the fluid stays in this area and starts to accumulate. This is where the lymphatic system kicks in. The lymphatic system consists of many tubes running parallel to the blood vessels and recollects any excess fluid and transports them to the subclavian vein near the neck. This way, excess fluids of the body and all of the molecules in them, are reintroduced into the circulation. If there is a problem with this process, an abnormality called “edema” occurs. Of course, the blood is a very sensitive fluid because it travels through the whole body and seeps into almost every single cell. If a microbe were to get into it, it would easily spread and cause disease. So, the lympatics first does a checkup on the body fluid. This checkup occurs at special nodes in the system called lymph nodes found all over the body. Two of the most famous lymph nodes are the spleen and the tonsils. Within these nodes are lymphocytes, special immune cells that “tag” bacteria and other microbes to be later destroyed by macrophages. Thus, the blood is continuously cleaned and kept safe from harmful microbes.

Last but certainly not the least, the final inspection the blood goes through takes place in the kidneys. The aforementioned two checkpoints prevent the entrance of any foreign materials into the blood, and the elimination of any microbes lucky enough to somehow make it through. So, the only task to be completed is the elimination of excess molecules formed in the metabolism. For example, the blood in the veins (the vessels that carry carbon dioxide formed by the respiration of cells) is carried to the lungs where the carbon dioxide is exhaled. But, a much more precise mechanism comes into play in the kidneys. Blood vessels that come from all around the body form a knot-like structure in the kidney called the “glomerulus.” This knot-like shape increases the surface area of filtration. The blood running from the glomerulus is then filtered into the “Bowman capsule,” which surrounds the glomerulus.

But wait! The sanitation system is not satisfied with this first filtration and “thinks” that the filtrate is not ready to be excreted by the urine. So, a more delicate filtration occurs right after the filtrate enters the “proximal tubule.” While passing through this tubule, essential molecules are immediately reabsorbed into the body. The most valuable of all these molecules is glucose, since it is the main source of energy in the body. The proximal tubule reabsorbs around 98 % of all the glucose, while the distal tubule scouts out the rest. After the tubules are done with the filtration, not a single glucose molecule is left in the urine. As a matter of fact, the presence of even a few glucose molecules in the urine leads to a diagnosis of “renal glycosuria.”

After the proximal tubule, the filtrate goes into the “loop of Henle,” where it is dipped into a high-concentration environment. Water travels passively (without the need for energy) from low-concentration to high-concentration areas. In the loop of Henle, the urine is low-concentration, so water runs back into the body. Thus, any excess water in the urine is effectively and economically reabsorbed. The big machine that consists of the glomerulus, the Bowman capsule, the tubules, and the loop of Henle is called a “nephron.” Everything described above occurs in a single nephron. The average number of nephrons in one kidney is around 1,000,000. The human bladder holds around 150 ml of urine on average. So, each nephron is actually responsible for 0.00015 ml of urine production. The kidneys filter over 1,000 liters of blood each day, so our blood is kept just as we want it. Millions of tiny nephrons work in unison to take in huge amounts of blood and they know exactly what to leave and what to keep, 24 hours a day, 7 days a week.

Our blood is our life source. It is the milk of the organs, and our organs would dry up without it. Believe it or not, our organs are quite picky. If they are to receive anything they don’t like, they will start acting up. In order to keep the organs happy, the three mechanisms mentioned above have to work hard and not make a single mistake. These mechanisms are, of course, also made up of cells. These miniscule cells “know” exactly what their clients on the ends of the body like and don’t like, and prepare the blood composition accordingly. Only one word can describe these wondrous mechanisms: Impeccable.

Brian Turk is a medical student from New Jersey. He writes on medicine, health, and biology on a freelance basis.

Our sun is a single star system, but using new technology, scientists are discovering double – and even triple! – star systems

The planets of the sun revolve around a single star, just like the planets in many systems. Revolving around a single star is the general principle, but scientists have recently discovered planets that revolve around two stars, without causing any irregularities. Planets that revolve around two stars are accepted as a new class of planets and according to calculations their numbers in the Milky Way galaxy are estimated to reach at least ten million.

How can this be possible? A planet traveling around two stars enters the gravitational field of each star during its motion, and its velocity and orbit constantly changes.

If stars can shade (eclipse) each other, it is possible for one planet to shade one or two stars. When this event takes place, the planet and stars orbit on the same plane. This intersection on the same orbital plane means that the planet and star have passed in front of each other; we can measure this due to a reduction in the amount of light emitted by the star. If the distance between the two stars is too long, these stars act as if they are isolated from each other. In that moment, the planet that is moving on one of the star’s orbits does not feel the effect of the other star. These are called S-type planets and dozens of them have been discovered in the last decade.

Interesting events take place when stars get close to each other. In such cases, the time required for stars to make a complete revolution around each other is described in days or weeks. The ability of a planet to move in “braided pathways”^[1] that will allow a stable orbit around two stars that are so close to each other cannot be a coincidental event without fine adjustments.

S-type systems are only one type of double-star systems. In P-type systems, the planet revolves around the two stars simultaneously. For this type of planet to travel in a stable orbit, the orbital distance from the stars must be longer than a critical distance. If it is closer than this critical distance, the planet’s orbit becomes progressively unstable, and it is either pulled towards one of the two stars and collides, or gets thrown into outer space. This critical distance is 2/3 of the star’s magnitude.

In a system of a single star and planet, the transit of the planet occurs as if the light makes a periodic movement, such as when a light house rotates around itself. These passes allow us to detect stars. Double-star planet systems are another example of this. It is not easy to estimate the movement of an object consisting of three elements. In a single-star system, the star’s movements are stable; thus, it is easy to estimate the movement of a planet. Yet in a double-star system, the distance between the two stars is much shorter than their distances to the planet; for this reason, these stars revolve at a higher speed around each other than the planet revolves around them. This means that the planet’s rotation is difficult to predict.

As a result, the planetary movement of a double-star system will not be periodical; different than that of a single-star system, the time of transit passes will vary according to the relative motion of the planet to the star. If the planet and the star it revolves around are moving in the same direction, the transit pass time will be longer; but if the star is located at the other half portion of the orbit and traveling in the opposite direction, the transit passing time will be much shorter.

The Kepler spacecraft and telescope that NASA launched in March 2009 is designed for detecting planets that cause reductions in the light of stars when they are passing in front of them. Today, more than two thousand twin star systems that display eclipses have been discovered. Two planets that revolve around stars eclipsing each other every 7.5 days were discovered and called the Kepler-47 system. Along with these double star systems, a triple-star system has been discovered through the Kepler telescope; the properties of this system are extraordinary.

Among these, planet Kepler-47b of the inner region completes its voyage around its stars in less than 50 days. In addition, this planet, which is not visible directly, is predicted to be a very hot planet. Since a foggy layer inhibiting its visualization is found to have formed as the result of methane gas combusting in its hot atmosphere. Kepler-47b, which is three times bigger than the Earth’s radius, is the smallest planet among those that have been discovered in two-star systems.

The planet Kepler-47c of the outer region completes its one full tour around its twin stars in 303 days and it moves in a region that is described as the habitable zone in the Milky Way galaxy. There can be liquid water present on the surface of a planet in the habitable zone. However, just being in this zone does not totally mean that the place is suitable for life. Kepler-47c is predicted to be slightly bigger than Neptune and to have an atmosphere composed of thin and bright water-vapor cloud.

Reference

William F. Welsh, Laurance R. Doyle, “Worlds with Two Suns,” Scientific American, October 2013, pp. 40-47.

S- And P- type planets traveling around two stars

Kepler-47c exists in the habitable zone and liquid water is predicted to be present on its surface.

A representative image of the Kepler 16a/b based on acquired data.

^[1] The Qur’anic verse “By the heaven full of braided pathways, surely you are in contradicting views”(Adh-Dhariyat, 51:7-8) sounds like pointing to this phenomenon.

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As science develops further, the “veils” of the universe are lifted and humanity can explore realms beyond which our senses would normally allow.

We are conscious beings and we seek answers to our existence. People search for answers to questions like, “Who am I and why do we exist?” The sciences reveal that existence is full of meaning and purpose. However, judgmental values and beliefs enter the process; restrictive and ideological approaches lead to confusion during man’s voyage to truth.

Take the question of how we exist. Different perceptions have their own point of view and reach different conclusions. While a materialist person accepts the matter to be eternal, for some the theory of evolution has all the answers; yet on the other hand, a person of faith explains existence with creation. Therefore a materialist, an evolutionist, and a believer struggle to reach a common conclusion.

Human vision is somewhat veiled; the things that are not witnessed are considered unknown. The events of both the micro and macro cosmos are veiled to us. Yet the more our science advances, the more of these worlds we begin to see. We understand how complex existence is, while also appreciating how majestically it has come into being.

Can senses and observations guide humanity to the truth? Our strongest senses are seeing and hearing; however, these senses can only perceive a narrow band of the electromagnetic spectrum. The human eye can see the wavelengths in between 4,000-7,000 angstroms; the ear can hear frequencies in between 16-20,000 Hz. When we rely only on our senses to understand and comprehend existence, the things that are outside our ability to see or hear become absent.

Dimension and distance are very important for vision. The dimension that humans can see with the naked eye starts at the millimeter scale; in perfect conditions, we can barely see beyond 18-25 miles. Things at dimensions much smaller than a millimeter and at considerably longer distances remain out of our visual range. A microscope brings the small dimensions into our visual spectrum and the telescope does the same for long distances. Before the invention of these devices, humankind was not aware of things such as the atom, molecule, galaxy, nebula, or black hole. Today, because of scientific advances, as we get closer to seeing things on the nanometer dimension, we are newly discovering structures at this scale and the laws that are effective here. The inner makeup of the atom has not yet been elucidated; our knowledge is based on certain theories and experiences. Our information regarding the universe is also limited. It is considered that in an expanding universe, according to the expansion velocity of galaxies and gravitational force calculations, the amount of visible matter only corresponds to 4% of the total mass of the universe, the rest estimated to consist of 26% dark matter and 70% dark energy.

When the true nature of things (objects, existence) that are unknown or seem to be simple are explained through science, the truth is found to be very different. From space, the earth looks like a small and pale blue dot. After getting closer, at first the oceans, continents, and major mountain ranges start to appear. There is not any indication of people or other organisms on earth yet. However, after looking closely enough, it is observed that earth is filled with numerous life forms.

We witness the twinkle of countless stars when we gaze at the sky on a dark night. These stars, each shining as a small spot, may seem insignificant. When we turn our telescope towards one of these spots, we face a giant star or a galaxy that houses billions of stars; we become astonished. And when we take a better look at these stars, some of which are colossal, we witness interesting events. In these thermonuclear cauldrons that are utilized like millions of atomic reactors, enormous amounts of energy are released into space after being produced each second under immense pressure at temperatures reaching millions of degrees. Humans should think for a while and be amazed by these things. The power required is immense and they last millions of years.

People can also observe the wonder of the universe by delving into much smaller dimensions (the micro world). Here, we witness the creation of wonderful beings and the employment of tiny creatures in vital tasks, even though this micro world is hidden secret from the naked eye. For instance, in the thousands of small chemical factories fitted in a seemingly plain leaf, sugars are produced from carbon dioxide and water via sunlight; nutrients are synthesized from various minerals in the soil and stored in the fruits, seeds, and roots of plants to serve as nourishment for the living.

The biological structure of a human body is built by the proliferation of a fertilized single cell, called a zygote, through division. More than 200 different cells executing very unique functions in tissues such as the brain, liver, kidneys, muscles, and bones are created from a single cell. Cells have specific structures and tasks according to their types, each housing various work benches and laboratories. For example, the make-up and function of a brain, liver, or muscle cell is very diverse, each shaped for their assigned task. The organelles inside the cells are also specialized; the job of one cell type cannot be completed by another. The molecules, secreted enzymes, and hormones synthesized in cells are different. While a pancreatic cell secretes insulin and glucagon, a thyroid cell releases thyroxine. Various dimensions and models of protein, hormone, enzyme, and antibody molecules are formed with structures called ribosome to be employed in unique processes. The energy that cells need is generated in organelles of mitochondria. In addition, various transmission lines, communication networks, and defense mechanisms are established inside cells.

Organs are not just packs of meat. Billions of cells in each organ are completing their works around a common goal. In each organ and cell, micro factories and laboratories of microscopic dimensions are set up, micro-machines and robots are being utilized, and atoms and molecules are employed like conscious workers.

The entire body is formed by the specialization of this zygote into very diverse cell types during the formation of these organs. The set of tasks in different organs is programmed to sustain the life of a single organism and to serve a common goal. How could one not be amazed by the combination of trillions of cells in a way to serve one purpose, form a body, and distribute tasks to different organs?

It is also important to analyze the composition of atoms and their relations with each other for a better understanding of the facts of creation. Different atoms form with varying numbers of protons, neutrons, and electrons in their atomic structures. A different element is generated when the proton number is changed; an isotope of the same element is generated with the replacement of the neutron number. Millions of types of molecules with unique features can be made via different combinations of atoms. Molecules are the smallest units that determine the chemical properties of matter. While the simplest compound is the hydrogen molecule, formed by two atoms, there are also molecules composed of millions of atoms.

There are molecules of diverse types and sizes present in the universe. Each molecule type is constructed in a three dimensional and unique way. The number, order, and shape of the bonds present among atoms in a molecule, even the angle between atoms, is very important. Because of these differences, despite the fact that they both contain a carbon atom, a diamond and graphite (coal) are distinct substances. The carbon atom can miraculously form 1,700,000 types of compounds on its own. Just as in hydrogen peroxide (H₂O₂,) and water (H₂O) molecules, a change of an atom in a molecule can alter the entire property of that particular molecule. A small change taking place on a single base sequence of the DNA chain may disrupt its condition leading it to be ineffective or cause a disease.

As humans, we only observe the tangible side of such materials. Yet the universe contains multitudes that we cannot detect or know. Just like a software composed of commands is required for computers and electronic devices made up of physical elements, the presence of an intangible world that is dominated by souls and commands undetectable by senses is necessary within the matter where the program of fate is operated.

As mankind accumulates knowledge about the universe and existence, we notice that not only do we have a greater understanding of the nature of things, but also that each dimension in existence is a veil and this veil is lifted with science.

Grace is a very significant feature of the Prophet’s character. In fact, whichever characteristic of him we may consider, he was able to make the best out of them so that all of his efforts paid back many times as much. Grace relates to his benevolence, generosity, and unselfishness. While these terms are differentiated from each other by tiny nuances, they all indicate the same point. The Prophet was taught by God, thus his character developed with the morals of the Divine, which he practiced so well that He did not waste even an iota of it. Then, God Almighty returned the results of that divine morality, but with a multiplied amount. The Prophet, as being the Pride of Humanity requires, has surpassed all people – and even the angels.

In fact, this is not something reserved to him exclusively. That is, whatever someone grants on the way to God’s contentment shall return to him/her a multiplied amount. Many of the verses of the Qur’an state this fact very clearly: “Whoever comes to God with a good deed will have ten times as much” (6:160). Yes, if a person does a unit of goodness, God Almighty shall multiply that goodness by ten and return it to him/her. This is the least degree of divine favor. God Almighty sometimes multiplies by hundred or thousand. It depends to a certain extent on one’s depth of sincerity. He may multiply even by thousands, in accordance with the depth that that particular person subjectively loads on that particular practice of worship. Still, depending on the particularity of certain days and nights, or on the degree of altruism and unselfishness of that person, and on the firmness of his/her association with God, God Almighty may grant him/her a million times more. In sum, something like that may happen to every single person. However, the Prophet, we can confidently argue, benefited from this potential in full and made the best out of it to the last drop.

Grace is one’s being locked on or knotted around benevolence, or that one’s nature is completely engaged in doing favors to others. Actually, this emotion is shared to a particular extent by any human being. However, some people dull this emotion, whereas some others enhance it by a life-long process of practice. When they do this, the path of grace becomes the main road for them. By this way, they live their life always as a devotee radiating around pearls of grace, without straying in any other direction.

Due to the heavy mission he was loaded with, God favored the Prophet immensely from the very beginning. Parallel to the magnitude of this load, his nature was equipped with kernels that were able to shoulder this weighty task and responsibility. Nonetheless, he improved those kernels and extended them beyond expectations. By means of His all-covering divine knowledge, God Almighty had taken into consideration that the Prophet was going to give his willpower its due in the future, and bestowed him, at the very beginning, grandeur exceeding all other creatures.

Grace covers his character of benevolence as well as his capacity to be blessed with wonders – as he gave away in charity, God bestowed upon him His favors. As each of these incidents also served to endorse his messengership, they can certainly be considered miracles. Indeed, miracle is defined as something wonderful created by God through the hands of a prophet, particularly aimed at the confirmation of his prophethood. The Prophet’s nature, peace be upon him, was already prepared to welcome such wonders.

Grace and generosity have been among the key features of praise throughout history. It is reported in a story that Prophet Abraham owned a herd of livestock, and he had shepherds and dogs to attend them. When some angels, according to the story, could not reconcile his mission with this extensive wealth he owned, God told them to test Abraham. Angels visited Abraham in human form, and when they came close, they praised God, saying, “You are All-Glorified, All-Holy, the Lord of angels and the Spirit,” and they made sure Abraham could hear their prayer.

Each single one of these words were chosen precisely in the name of the glorification and sanctification of God. The true value of chosen words in a poem can be appreciated by true poets and experts of oratory; similarly, the very fine selection of these words would certainly be appreciated by Abraham, whose conscience was able to perceive the situation. Therefore, once he heard the angels verbalizing that utterance of glorification, he almost lost himself and said: “what a beautiful expression! Please say it once more; I will give you one fourth of this herd in front of me!” And when they did so, he offered them half of it for one more utterance. And when said it once more, he declared “I am a slave of yours, together with my shepherds!” As you see, if wealth is firmly connected with that kind of feeling, it becomes a vital support, instead of opposing the post of prophethood.

Prophet Muhammad, too, peace and blessings be upon him, was blessed with wealth through Khadijah, his beloved wife, who was a reputable businesswoman. Nevertheless, by the second or third year following the advent of his call, they had nothing to eat. That huge fortune had almost melted for the sake of mission, spent on banquets to win the hearts of people, or to decrease the tension of conflict. But at the end, that huge fortune was used up. It was consumed to the point that the Pride of Humanity started to bind stones on His belly in order to rid himself of his hunger. You see, this generosity and grace inherited from Abraham was not something unfamiliar to the people of Mecca. And, any member of this city used to have a share from this grace, in accordance with their personal position. However, no single soul was in a position to compete with the grace of the Prophet – even before his prophethood. Indeed, God’s Messenger was the final and the most inclusive fruit of the tree of Abraham. He inherited almost the whole grace of Abraham. This grace increased after the prophethood, and God’s Messenger became an embodiment of grace and generosity.

Especially during Ramadan, as Aisha stated, God’s Messenger was like winds of grace and abundance; he used to give away everything he could to the people around him. For God’s Messenger, accomplishing the exalted mission God Almighty had loaded upon his shoulders was a blessed ideal, even an ambition. God Almighty modified and consoled him in the Qur’an by saying, “Yet, it may be that you will torment yourself to death with grief” (18:6). However, he never gave away his wealth in vain; in contrast, he appreciated doing so on the way to God’s contentment. He scattered whatever he was endowed with like seeds scattered on soil, and every single grain he scattered became an everblooming flower.

The devotees of today, who are striving for the good of all humanity “so that others may live,” are in no different a situation, as they may be considered as inheritors of the prophetic mission. These inheritors should behave in exactly the same way as the Prophet, who revived the character of generosity and grace in His own era and elevated it to its zenith. Taking him as a role model, we can invest all the resources God has given us in education, without wasting a penny. Yes, our generosity has brought about, and will bring about, results that are vitally important for the future of humanity, and so valuable as to be worth all sacrifices.

If attraction means that one is drawn by a sacred power linked with his or her essence toward the purpose of his or her creation and to the point indicated by his or her true, primordial nature, injidhab means the willing acceptance of this invitation to the spirit.

Attraction is so great a Divine favor that it cannot be obtained through ordinary means or causes. It is God Himself Who grants to His pure-hearted servants both the attraction and the ability to receive it: That is the grace of God: He bestows it on whom He wills (57:21). This bestowal includes, in a single, passing moment, many portions of time filled with events, and it equips a single step toward Him with the potential to reach the gardens of Paradise, and a single glance with the capacity to turn a piece of coal into a diamond. Great distances that seem impossible to cover with one’s own will and power are covered in a moment by God’s attraction, and high summits are reached by His uplifting, as stated in: A single instance of the All-Merciful’s attraction equals to the nearness to God acquired through the good actions of both humanity and jinn.

Those whose spirits feel the mysteries of faith, who practice Islam and perfect goodness and devotion through God’s attraction are called “those who follow the way of Uways,” for they are guided directly by God or the Prophet and they feel continuously attracted toward God by God Himself, living in incessant ecstasy and amazement at what they observe of the Divine truths and manifestations.

At times, there is a virtuous circle between attraction and regular worship and austerity. A traveler on the way to God is favored with attraction in proportion to the degree of his or her worship and austerity, and is devoted to worship and austerity to the extent of the attraction felt toward God. So long as such people act in accordance with the Shari’a, this virtuous circle continues. If they break away from the light of Muhammad, upon him be peace and blessings, displays of free and easy behavior in their relationship with God begin to appear, and religious obligations might begin to be neglected.

Attraction is, first of all, a capability and a Divine gift given in advance. Without this gift, a traveler on the way cannot feel attracted through austerity, worship, and self-purification; nor can he or she discern the waves of attraction and being attracted on the face of the universe produced by the light coming from the Divine Name the All-Loving. Such an undiscerning person has no knowledge of true spirituality:

Why should my guide be concerned with me
unless I have the attraction of love?
Why should he be concerned with me
Unless I receive inspiration from God?

It sometimes happens that a believer attracted in this way is overwhelmed by the gifts coming from God, so that whatever is other than His manifestations disappears, and all cares with the world or the Hereafter are forgotten. In a mood expressed by the following couplet by Muallim Naci:

I am, by nature, so attracted to the roaring rise of the sea
that I feel as if engulfed in the bounteous gifts of God,

one’s self and all other parts of creation are seen as being intoxicated with the attraction of the All-Holy, Attractive Being:

Everything is intoxicated with the wine of love of God and the attraction of this love. Celestial objects and angels are intoxicated; the heavens and the earth are intoxicated; elements and plants are intoxicated; and animals, human beings, and all other beings (are intoxicated).

There are two kinds of attraction. One is felt inwardly and is not manifested outwardly by its possessor. Such a person loves God, feels great contentment with and pleasure in fulfilling His commandments, and feels incessantly attracted to the source of a deeper delight. The second kind of attraction is that which is manifested. One who feels such attraction cannot help but manifest it as ecstasy. Feeling attracted by God with a continuously increasing force, he or she lives as an ecstatic, in excessive joy and with great happiness.

Those who are unaware of such degrees of spiritual elevation think such a person is crazy. The following couplet of ‘Abdu’l-‘Aziz Majdi Efendi expresses this degree of ecstasy quite meaningfully:

There is a kind of madness called attraction, which is a secure triumph.
By means of it mysteries of madness reach higher and higher.

Attraction may look like madness in some respects; in reality, it is quite different. For example, an ecstatic who revolves in waves of attraction may lose some perception and show signs of madness by behaving in ways incompatible with sound reasoning and the Shari’a. In most cases, an ecstatic exceeds normal human standards in all senses or powers of perception to the extent that, in the light of Sunna, he or she travels in realms that cannot be reached by the reason, other intellectual faculties and senses of ordinary people. Therefore, those who see such a person think that he or she is crazy.

However, traveling (in spiritual realms) beyond the reach and power of normal standards of intellect or reason, by using that power and other senses along with the help of God, is completely different from the type of madness resulting from mental illness, which is characterized by less-than-normal standards of intellect or reason.

O God! We ask You for the means which will attract Your mercy and forgiveness, protection from all sins, acquisition of all virtues and godliness, the reward of Paradise, and salvation from the Fire. And bestow blessing and peace on our master Muhammad, the master of the godly and virtuous.

Worship is essentially categorized into two sections: worship through financial/material means and physical/bodily worship. This categorization does not mean they are totally unrelated; in many ways, they are interconnected. For example, the daily prayers that we perform with our bodies certainly have material aspects, like time and place. As a matter of fact, the inner and outer conditions that are required for a proper prayer (like cleanliness, washing, dressing, etc.) are also related to the material world, too.

Alms is a kind of fiscal worship, but it also requires one to labor in a job or be physically present in the marketplace, so as to achieve a certain degree of wealth from which to give charity. The Hajj, the Muslim pilgrimage to the holy lands of Mecca and Medina, is a financial worship, in one aspect, and a physical form of worship, in another: a Muslim has to be financially able to afford the travel to the holy lands, where he or she has to endure physical difficulties, like the long trip and certain rituals, like circumambulation around the Ka’ba, standing vigil all day, etc. Fasting, too, may be considered within this frame. Four of the five essential principles of Islam have a considerable association with the material world as well as the spiritual one.

In today’s world, it is important to contribute to good religious services by alms, charity, and donations. But such financial contributions do not absolve one from other forms of worship and good work that need to be performed physically. For example, Abu Bakr had been among the well-to-do of Mecca when he met the Prophet. Bu he spent all his wealth for the sake of Islam and he had nothing to leave behind when he died. He also physically participated in the emigration to Medina and he also fought in many battles.

Financial worship may be more important at certain times. But, this is not an absolute truth. It varies depending on time, place, and the respective conditions of people.

We can assess the issue from two perspectives: 1) Giving less or more charity depending on wealth; 2) giving within certain parameters. There exists a distorted and incorrect understanding among some believers. They say: “My financial situation is not high enough, I do not own a fortune; so, I am not obliged to observe any financial worship.” No; this thought is absolutely wrong. Every single person is obliged to observe his or her responsibilities within the capacity bestowed upon him or her by God Almighty. However much or little one earns, believers should always seek God’s good pleasure by giving in charity as much as they can, for God considers sincerity, rather than the amount given. In the words of Bediuzzaman, “An ounce of sincere worship may sometimes be superior to the one that weighs pounds but is not practiced in sincerity.” As a consequence, every single person is obliged to mobilize on the divine path to God’s contentment.

It is very difficult for a person to both give away in charity and maintain his or her sincerity. Those who can manage this will surely be rewarded beyond measure. If one can overcome the welfare and comfort that come with wealth, can avoid ostentation, and can keep their sincerity and connection with God strong, their rewards will surely be abundant in proportion to the difficulties they face.

The second aspect of the matter relates to the parameters and guidelines for such donations. There are certain minimum degrees for financial obligations in charity. In the case of Islam, for instance, it is compulsory for wealthy Muslims to give a minimum of 2.5 per cent of their annual wealth in charity. There are other rules for wealth in gold, silver, commercial goods, crops, etc.

But we have to remember that these are minimum figures and many lofty goals and good services cannot be attained through merely giving these minimums. Therefore, every single individual should work hard to donate beyond the minimum amount of obligatory alms. We wholeheartedly believe that whatever is given today in the name of God will be multiplied by the thousands in the next life. Yes, everybody is obliged to serve on the way to God with his or her self and goods. But there are no limiting criteria; everything is relative.

Even if we gave away all we own on the path to God, we should still see it as a very minor sacrifice when compared to the ideal we have been wishing to construct.

With half the world living on less than $2.50 per day and with 46.2 million people in the United States living below the poverty line, poverty is a growing concern.

The United States is known all over the world to be a very powerful and rich country. It is not just American people who believe in the American Dream, but also many people from other countries have been dreaming of coming to the US to live in better conditions. Although the US is thought to be a rich country, we still see hungry and homeless people, especially women and children in the streets. Women, who are either married or unmarried, whether supported by their husbands or single mothers with no support, struggle to earn money for food, clothes, safe shelter, and other intangible needs such as love and happiness. When observed closely, it is easy to understand the reasons why this is so. It is because of the wage gap between men and women, the decreased amount of opportunities in having high income jobs, and the fact that more women are the head of their household compared to men, means that the ratio of poor women is rising, and the increased need for governmental help makes “welfare” necessary.

Understanding the definition of poverty becomes very important because it categorizes people into groups which are poor and wealthy. Richard Ropers states that poverty can be understood and described in numerous ways, and that people will not understand the meaning of poverty if they do not recognize the situation of the poor. To be poor means to not have any sustenance, shelter, or any support from family. However nowadays, living alone, or being pushed out of society, being under depression of unchanging destitution also describes poverty. Being fired from a job, losing self-esteem, having no power, or being away from cultural values are also other parameters to describe poverty (Ropers, 25). Ropers also describes “widespread poverty” as a disloyalty to the democratic values’ failure to gain optimism. Successful leaders must aim to provide economical comfort for their citizens. If the majority of the people are not happy because of poverty, it means the government is not as strong to deal with the problems.

The official poverty line is inadmissible as an accurate system to determine the number of poor people. “The US government identifies the poverty line by multiplying the cost of a minimally nutritious diet by three,” then the number of people who live in the same house is calculated (Popers 35). According to the Census data for 2011, 46.2 million people in the United States lived below the poverty line. According to Peter Edelman, a law professor in Georgetown University, even though there are so many hard working people, they are still living in poverty or just barely above the poverty line (Bilitteri, 723). These people are not given the necessary governmental support. There is also a huge gap between the poor and the wealthy people in the US (Cooper, 337). The highest income is $102,000 for households, just 1% of the population, and the lowest earning is $250 for people, who make up 90% of the population, explains Thomas Piketty and Emmanuel Saez (Bilitteri, 723).

One given image portrayed in the media is that “the poor have only themselves to blame” (Mantsios, 638). The problem of poverty is not just one individual’s problem. There is a strong connection between the poor and society. How can a defenseless child be responsible for being poor, not having shelter, and for not earning any money? How can a single or divorced mother with a little baby, without any family help, be expected to work full time without feeding the little one for hours. The term “poor are eyesores” (Mantsios, 637) is not a responsible and thoughtful depiction, rather, it is a way of not being able to see the problems of the people outside and breaking away from the realities of the poor.

More and more women, especially single mothers, are experiencing poverty at a higher rate than the rest of society. Ropers notes that 58% of women are facing poverty, and in this category 48% of the women are the head of their household. According to Albelda and Tilly, 50% of single women are below the poverty line with no support of a husband. In 1993, while 16% of families struggled against poverty, simultaneously, 52% of single mothers, bereft of husband or family support, experiences real difficulty to provide for their basic needs. Most women work at least two jobs at the same time. On the one hand they work at home without earning any money, and on the other hand work outside to earn money (Albelle & Tilly 307). In 1947, about 38% of women were working mostly in paid labor jobs; however, in 1954, the number of working women who were African American, doubled to 54%. Then in 1996 the ratio of working women rose up to 88%, as reported by Albella and Tilly. Even though the number of hard working women is increasing year by year, they are still, except for a small percentage, earning low income and their situation still remains below the poverty line. According to Albelda and Tilly, “women’s earnings are considerably lower than men’s, approximately 70 cents to the man’s dollar.” This difference makes women’s lives miserable as they try to work outside and head the household all at the same time.

For so many years, women have been endeavoring to have the same rights, opportunities, and benefits as men have in their working lives. Although women’s working situations are not as bad as some years ago, women still face graceless and unpleasant discrimination when they look for jobs. Even though women are more educated nowadays and have more opportunities to get a job, there are distinctive wage gaps between men and women. Being the head of the family (Bernstein, 370), giving birth to a child, being under differentiation of occupation, and being sexually abused by employers are some of the common reasons as to why women are behind men when it comes to the benefits of the jobs (Wage Project, 373).

Family responsibilities are one of the most common reasons why women work in a part time job instead of having a full time job (Bernstein, 371). There are so many married or single women who do most of the household responsibilities while trying to work in a job. It is hard to deal with the chores and manage the expectations at work at the same time. For this reason, women in these kinds of situations prefer to work in part time jobs. According to Bernstein, only 25% of women are able to work full day, for the rest of the women cannot dedicate their whole day for work. This being the case, women cannot get the equal remuneration like other women who work in full time jobs. Interestingly, there is also a huge payment gap between women who work full time and men who work full time. Bernstein explains that “on average women work a lot less than men: 1,498 hours a year, vs. 2,219 worked by the typical man.” According to The Wage Project, part time women employees make only 38% of men’s full time yearly salary. Bernstein also mentions the Hartmann and Rose’s data which shows that women employees can have the same benefits if they leave all the family responsibilities behind and come to work behaving like a “traditional man.” The continuation of such unfair treatment is sure to wear down woman, a situation that’s already strained them enough.

Another reason for the wage gap between men and women is the choice a women makes to have a child (Wage Project, 378). Bernstein says after quoting Bergland that after delivering a child, women have to work part time or stay away from work for a while because they do not receive the necessary help from the society.

Nowadays, the position of women employees is assumed to not be as powerful as men’s by most bosses (Wage Project, 377). Even if men and women have the same educational level (Bernstein, 372) and women show more talent, the suggestions made by women are mostly not considered important until, of course, there is no other choice but to accept (Wage project, 375). Bernstein states that women’s yearly salary is much less than men’s, even when they are at the same educational level.

Sexual harassment is another important factor for women to leave their jobs (Wage Project, 377). Sometimes in situations like these, women are unfortunately seen as sexual means by their bosses. If the women, even if they are educated, do not accept the advances of their bosses, they have no choice but to leave or drop out of their jobs, benefits, emotional solidity, and sometimes even their lives (Wage Project, 377). Women encounter such discriminatory situations at the same time while they are dealing with difficulties which they have in their personal lives.

Some people think that people are getting welfare because they are too lazy and they don’t want to work. This theory can be true for just a few people. Making this kind of generalization for all people who are in poverty is derogatory against them. Albelda and Tilly say that the reasons for the poverty experience by single mothers and their families is not because of their laziness or lack of ambition. They are in poverty because they don’t have parent support, they face job discrimination, they earn less than men, and they have the added responsibility of taking care of their children. Blaming the poor is so easy, but being aware of their situation and helping them out of it would be the best thing for all.

Making reforms on the welfare program will make it work well. Some malicious people display themselves as poor to get support from welfare. Under the welfare program, the situation of the applicant must be clarified through an attentive investigation. Determining the really needy persons, eliminating their needs, and opening free high qualified career courses will make welfare a more beneficial program for the poor and will reduce the complaints made against the program.

Being in poverty is mostly not a personal choice. People in poverty don’t just lack food or safe shelter, but they have also lost their hope and happiness. Women, especially single mothers with no support, encounter the most difficult situations of all. Having an income less than men, taking care of their children without any support, facing job discrimination, and heading the family are the most common adversities faced by women today. Receiving no government support will not help reduce their problems; on the contrary, having access to effective government support will let people in poverty know that there are people with helping hands, people who care about them and who think about them. Poor people need helping hands, at least to not let them give up their hopes and dreams.

References

• Albelda, Randy.,& Tilly, Chris. 2001. “‘Women, Income, and Poverty’: There’s a Family connection.” Race, Class, and Gender in The United States. Ed. Paula S. Rothenberg. New Jersey: Worth,. 305-314.
• Billitteri, Thomas J. “Gender Pay Gap.” CQ Researcher 18.11 (2008): 241-264. CQ Researcher Online. CQ Press. Elisabeth Sturn Library, Reno, NV. “Domestic Poverty.” CQ Researcher 17.31 (2007): 721-744. CQ Researcher Online. CQ Press. Elisabeth Sturn Library, Reno, NV. Cooper, Mary H. “The Working Poor.” CQ Researcher 5.41 (1995): 969-992. CQ Researcher Online. CQ Press. Elisabeth Sturn Library, Reno, NV. 5 Nov. 2008 “Income Inequality.” CQ Researcher 8.15 (1998): 337-360. CQ Researcher Online. CQ Press. Elisabeth Sturn Library, Reno, NV. 5 Nov. 2008
• Glazer, Sarah. “Welfare Reform.” CQ Researcher 11.27 (2001):601-632. CQ Researcher Online. CQ Press. Elisabeth Sturn Library, Reno, NV. 5 Nov. 2008 Berstein, Aoron. 2007. “‘Women’s Pay: Why the Gap Remains A Chasm.” Race, Class, And Gender in The United States. Ed. Paula S. Rothenberg. NJ: Worth. 370-372. Mantsios, Gregory. 2007. “‘Media Magic: Making Class Invisible.’” Race, Class, And Gender in The United States. Paula S.Rothenberg. New Jersey: Worth. 636-643. Ropers, H. Richard. 1991. Persistent Poverty, New York: Plenum. Rothenberg, Paula S. (Ed.). 2007. The Wage Gap And Its Costs. Race, Class, And Gender in The United States. NJ: Worth. 373-378.

We can consider being actively involved in the service of God in relation to such motivations as finding present services as being insufficient, striving at one’s highest possible peak in competence and zeal, never losing heart or getting weary with the ideal of transforming the world into a paradise, and to remain steadfast in taking this mission to the end, as far as it goes. By saying “the end” we mean the horizon, which is the answer to the secret mentioned in the question, marked in the verse “(continue to) worship your Lord until what is certain (death) comes to you” (15:99). That is, to persevere in one’s servanthood to God as sincere and vivid as it can be till death comes round at last. Yes, leading this spirit till that day is a real and genuine activity and action. In both personal and social perspectives, if one is concerned with all their heart and soul of the duties and responsibilities that pertains to their servanthood to God, and contrives to perform them, it means that they have comprehended and practiced activities and action in the right way. In contrast, if people take up the issue in a single dimension and delve into services only in the material sense exclusive of the spirit of servanthood to God, their services will slide away leaving them empty-handed, even if they make their country the most prosperous in the world. Furthermore, even if these people save the world with a single move, but afterwards fall into the web of reliance on their good deeds, I would state at ease that whatever they have done will not be welcomed by the All-Truthful One.

Keeping this meaning and spirit alive depends on the following dynamics:

1. Engaging oneself in deep mental activity. Yes, the utmost flaw of us human beings is mostly that we live far away from and unaware of any sort of contemplation and analysis. Moreover, we lead a life with dead hearts, deprived of self-control.
2. Meditation on the reality of death (rabita al-mawt). That is, thinking about death incessantly and becoming free and easy with it; associating oneself every single day to prepare for the time of appointment with the angel of death. For this, hospitals should be regularly visited, and visitors should engage closely with the people staying there. Graveyards should also be frequented, for the ephemerality and the mortality of the world should be remembered by imagining oneself as decayed bones. Besides, one should strive to leave a work behind within the consideration that “people die, but their work shall remain behind.”
3. Not remaining separated from the blessings bestowed upon the collective consciousness. Sometimes a person may collapse in his or her inner world. This ruin can be restored by staying in the benevolent climate of one’s community. Our own eyes, ears, hands and feet may sometimes not be sufficient to overcome the negative atmosphere we happen to be in. In those times, we can attain a might beyond our own when we hold with the hands of our friends, see with their eyes, and hear with their ears.
4. Reading books to keep alive metaphysical tension. Yes, we can only attain the immense horizons of thought of the pioneers and of those numerous great figures modeling us in this way by reading their glorious life stories. And by doing this, we can save ourselves from the choking atmosphere of habituation and familiarity, and from the attractive beauties of the world.
5. Assuming a duty as responsible individuals in order to remain vivid and active in community service. In this way, one often comes together with like-minded individuals who aim to serve their community. They keep themselves busy with the outcomes of completed works, and with the consultation of those in the future; they sleep and wake up with those thoughts, and breathe service without being left inoperative even for a moment. And if they behave like this, God Almighty shall make fruitful their love and enthusiasm, as well as their activities and action. The Divine saying, “Whosoever approaches Me by one span, I will approach him by one cubit; and whosoever approaches Me by one cubit, I will approach him by one fathom, and whosoever comes to Me walking, I will go to him running” refers to this truth. The brave ones who have been shouldering such good works at such a time of difficulty should initially be aware of their values through contemplation, and then transcend the ephemerality and the mortality of the world through meditation on the reality of death, and even manifest the ways of genuine existence while still mortal by being among friends on the path of service. They shall be together with those friends everywhere and every time, at times of sorrow and happiness, and they will multiply up to thousands with their singularities.

Being the representatives of virtual loyalty, those chivalrous heroes of benevolence shall run to service with an overwhelming enthusiasm as if they reunite with the forerunners they have modeled and regarded as their guides and pioneers. With this motivation, they will fulfill one heroism after another and will realize a world heralded centuries ago.

May our Lord raise our generations with His glorious favor, benevolence and grace! May He fortify those of us in His service with His might on this path of tremendous struggle that exceeds our power! May He make this service abide with us and the generations to come! May He please those alive and those who have passed away by making faith in Him everlasting.

The cell is the structural, functional, and biological unit of all organisms. All information needed for numerous processes in a cell, including repair and division, is contained in DNA (Deoxyribonucleic acid). DNA is a huge single molecule with intriguing features. How can a single molecule have such a dominant role in preserving information essential for the continuation of life? What are the mechanisms and levels of organization during its function? What does DNA mean for a single cell or for a human being? It’s impossible to answer these great questions in a single article; however, understanding the ways DNA exerts its role, DNA’s impact on multiple levels ranging from a single cell to an organism, and coordination between various levels, can potentially open up new frontiers in our mind and in our perception of life.

“Double helix” architecture of DNA DNA has an elegant structure that forms the basis for all of its functions. DNA is a repeating structure of nucleotides. Each nucleotide is formed of a phosphate group, 5-carbon sugar (deoxyribose) and a nitrogen-containing base attached to the sugar from outside to inside (See Figure 1a for a schematic view of DNA). There are four types of nucleotides in DNA, differing only in bases. We can consider bases as the identity of nucleotides. These four nucleotides are shown with letters A (adenine), T (thymine), G (guanine) and C (cytosine). Thousands of nucleotides bound with sugar-phosphate covalent bonds come together to form long strings. The sugar-phosphate backbone can be imagined as the steelwork of a skyscraper. The nice thing about nucleotides is their specific match to each other in double helix. A forms a base pair with only T, and G forms a base pair with only C. These pairs are bound to each other with hydrogen bonds. This feature is the key that makes DNA a double ladder. Two strings of nucleotides form a double helix by selective interactions of As with Ts, and Gs with Cs (See Figure 1b for 3-D structure of DNA). In DNA structure, hydrophobic bases tend to stay inside of double helix and hydrophilic sugar-phosphates stay outside interacting with water in nucleus. This feature helps DNA to form a double ladder. The length of the sugar-phosphate backbone is more than the bases. To compensate for the length difference, the sugar-phosphate backbone wraps around the bases inside, as a road wraps around a mountain to climb to the top. This simple difference is the main reason for DNA to form a helix.

The double-stranded nature of DNA with specific base pairing is one of its key features as genetic material. DNA is replicated using one strand as a template. Replication machinery reads one strand of DNA and builds the second strand by putting As against Ts and Gs against Cs. If a mutation occurs in one strand, it can be repaired using the second strand. This system is like photocopying DNA from itself instead of building it from scratch every time. That is why specific base pairing of nucleotides in the double helix makes it possible to replicate DNA through generations, protecting its integrity and information content. The code of DNA, an alphabet with four letters DNA contains the information to produce nano-sized cellular machineries called proteins. We mentioned that there are four types of nucleotides. Nucleotides are like letters in DNA, three of them are code for one amino acid of protein. We can make it more understandable by giving an example: “ATG-GCC-CTG-TGG-ATG” as a nucleotide sequence of DNA corresponds to the first five amino acids of a protein called insulin (a hormone regulating blood glucose level that is important in diabetes) and amino acid sequence is methionine-alanine-leucine-tryptophan-methionine. The code is so sensitive that even a single mistake in the sequence of DNA can cause serious diseases in humans such as sickle-cell disease or cystic fibrosis. With all these nucleotides, DNA can be thought of as a book containing amino acid sequence information for thousands of proteins (about 30,000 in humans). The amount of information contained in DNA is incredible: a typical human cell contains 2 meters of DNA that is tightly packed by proteins in the nucleus. If we tried to write the information from DNA into books, the book would contain over one billion words and 1,500,000 pages. DNA-protein interdependency and the cell as a micro-factory DNA can be thought of as an instruction manual that stores information for proteins and RNAs. Proteins, as molecular machines, perform particular tasks such as energy production and synthesis of DNA and RNA (See Figure 2 for the structure of proteins). Certain proteins read the information on DNA and make a transient copy of certain regions of DNA. These copies are called messenger-RNAs (mRNAs) and mRNAs are transported from nucleus to cytoplasm (See Figure 3 for representation of mRNA production from DNA by proteins). In cytoplasm, the information on mRNAs is read by protein complexes called ribosome. Ribosomes produce new proteins processing the data from mRNAs. This information flow from DNA to proteins is called central dogma in molecular biology (Figure 4). The data that is encoded in DNA can be read, translated, and put into the form of product only by proteins. We can conclude that for a protein to be produced, DNA is essential; for DNA regions to be read into proteins, proteins are essential. So, there is interdependency between proteins and DNA. Proteins without DNA have no future and no ability to regenerate and DNA without proteins is just like an instruction and manufacture manual of a computer without the user and computer itself. We can imagine the cell as a sophisticated factory, and proteins as the machines of the factory. DNA includes the instructions for the factory to be rebuilt and for itself to be rewritten for every new factory. It has instructions on how to build every machine in the factory. It has also codes for when and how much of these machines should be produced (we will discuss more about these codes on DNA in the next section). On the other hand, the timing and control of all these productions also depend on machines in the factory. Some of these machineries read and decode the instruction manual, some of them produce new machines by reading the decoded copies of the instruction manual, some of them act as sensors for the signals, some of them transmit signals to other machines, some of them produce signals by measuring the levels of materials in the factory, some of them function in communication with other factories, and so on. As we can see, DNA and proteins are meaningful for life only when they are together in the excellent cell context. This is a perfect example of the principle that the whole is bigger than the sum of its parts, because each element of the cell system has limited potential, until it comes together with the others to blossom into life.

The famous term “Gene” We can think of genes as functional units of DNA. A gene has the information content for at least one protein. Humans have about 20,500 genes that are read by protein machineries to produce proteins. Special proteins read the information on genes and make a transient copy of these certain regions of DNA. The process of making a copy of a gene as an mRNA is called transcription.

Genes don’t only store information; they have an intrinsic architecture of design to coordinate transcription utilizing three main components: promoter, coding region, and terminator. The promoter is the gene region that signals for the start of transcription. Protein machineries bind to the promoter and activate transcription. The coding region has the information for the amino acid sequence of the protein. The terminator region gives the stop signal for transcription. There are different functional regions on DNA located between separate genes such as enhancer regions that are platforms for binding regulatory proteins to tune the transcription.

The coding region of genes has multiple reading blocks for amino acid sequences and these reading blocks are called as exons. For some genes, different combinations of exons can be put together to give rise to different proteins. This mechanism allows one gene to be able to produce multiple proteins, increasing the efficiency of genetic material. A similar mechanism is used to produce antibodies (proteins recognizing foreign antigens) by the immune system. Different regional genes come together by a mechanism of DNA rearrangement (V(D)J recombination) and their differential combinations form many different antibodies. For example, a part of the antibody that is called a heavy chain is produced by a DNA region containing 65 variable (V) genes plus 27 diversity (D) genes and 6 joining (J) genes (5, 6). This produces a combination of 65 V genes x 27 D genes x 6 J genes = 10,530 heavy chains. There is a similar mechanism of rearrangement for light chain and variable region of antibodies, which result in millions of different antibodies for host antigens. A single example in the immune system shows us that DNA not only has a decent design for the coding system, but it also has ingenious and creative mechanisms to maximize its potential.

Gene expression is orchestrated during development and formation of organs The human body which consists of more than 1013 (ten trillion) cells is generated from a single cell called the zygote (see Figure 5). This tells us that, in a single cell, all the information and instructions to build and coordinate the systems of human body is encoded. Different tissues and organs including muscles, nerve cells, connective tissue, and eyes are fruits of one single cell. They all contain the same genetic information. Then what makes them different?

Promoters, enhancers, and repressors located in and nearby genes are important in spatial and temporal control of gene expression in different cell types of the body. Each cell type in our organs expresses a different subset of genes; this is what gives a cell its identity. For example, in muscles, myosin is expressed and in the eye’s retina, rhodopsin is expressed. Myosin functions in contraction and rhodopsin functions in vision. What determines the expression of rhodopsin in the eye but not in a muscle? The determination process occurs during development by programmed interactions of specific proteins called transcription factors, and restricted regions of DNA including promoters and enhancers. During development, certain regulatory proteins in a specific cell type, bind to DNA regions of only some genes (for example, in future retinal cells of the eye, rhodopsin gene would be activated but not myosin) and this predetermination orchestrates differential expression of genes to give rise to hundreds of different types of cells.

Different layers of complexity and organization related to DNA

There are different layers of function for DNA—each subtitle of this article tries to focus on a certain layer of function. DNA as a molecule has a double helix structure and is replicated through generations to preserve genetic information. It stores genetic information and has a four-letter alphabet for the expression of proteins. In the second layer, DNA has an informational unit called gene and thousands of genes are encoded in DNA to contain information for proteins. Each gene is controlled individually by making use of promoters and enhancers. In the third layer, all processes in the cell micro-factory as an entity are performed through interactions of DNA and proteins with each other and among themselves. Proteins read DNA code and work as cellular nano-machineries. In another layer, temporal and spatial expression of genes on DNA are orchestrated and different subsets of genes give rise to different cell types and organs. Organs communicate with each other to function properly and keep the balance and homeostasis of the body. The information stored in DNA not only coordinates highly sophisticated processes of a single cell, it simultaneously projects the whole body system of a human being, which is billions times bigger than a single cell.

DNA functions in all these different layers and keeps a great harmony in coordination between various layers of function. After grasping this complexity, organization and communication from a single molecule, to proteins, to a single cell, to tissues and organs, and to a human being by utilization of DNA, should not we ask ourselves, “can these elements come into existence by random forces and collisions?

References

1. Calladine, C. R. et al. 2004. Understanding DNA: The Molecule and How It Works, Academic Press

2. http://www.genome.gov

3. Li A, Rue M, Zhou J, et al. 2004. “Utilization of Ig heavy chain variable, diversity, and joining gene segments in children with B-lineage acute lymphoblastic leukemia: implications for the mechanisms of VDJ recombination and for pathogenesis.” Blood 103 June (12): 4602–9.