{module Science Square (Issue 128)}

First miniature human heart printed

Noor N et al. 3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts.  Advanced Science, April 2019.

In a major breakthrough, researchers have “printed” the world’s first 3D vascularized engineered heart using a patient’s own cells and biological materials. This could have huge repercussions for human health: the World Health Organization said that last year, ischemic heart disease and stroke were the world’s leading cause of death for both men and women. Heart transplantation is currently the only treatment available to patients with end-stage heart failure. Given the serious shortage of heart donors, scientists have been trying to develop new “3D organ printing” approaches to regenerate the diseased heart. Past studies were only able to print simple tissues without blood vessels. The new study showed for the first time that an entire heart with cells, blood vessels, ventricles, and chambers could be successfully engineered and printed. The researchers first took a biopsy of fatty tissue from patients and separated the cellular and a-cellular materials of the tissue. While the cells were reprogrammed to become pluripotent stem cells, the extracellular matrix – a 3D network of extracellular macromolecules such as collagen and glycoproteins – were processed into a personalized hydrogel that served as the printing “ink.” After being mixed with the hydrogel, the cells were then robustly differentiated to cardiac or endothelial cells to create patient-specific, immune-compatible cardiac patches with blood vessels and, subsequently, an entire heart. The heart was 3D-printed in about three hours and was too small for humans. It was the size of a rabbit’s heart (~ 2.5 centimeters). But it is completely biocompatible and, most importantly, matches the patient, which reduces the chances of organ rejection inside the body. A human-sized heart might take a whole day to print and would require billions of cells, compared to the millions used to print these mini-hearts. While it’s not clear if a printer can produce hearts that are equal or superior to human ones, perhaps by printing patches there will be a possibility to improve or take out diseased areas in the heart and replace them with something that works. Researchers hope that maybe in 10 years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely.

Bacterial factories for spider silk

Zhang F et al. Synthetic Biology for Microbial Production of Protein-based Materials, the American Chemical Society (ACS) National Meeting & Exposition, Spring 2019.

Spider silk has always fascinated researchers due to its lightweight and superior strength and numerous applications in areas such as drug delivery, smart textiles, and artificial muscles. It is one of the strongest natural materials in the world. It is thinner than a human hair, but its strength is more than that of steel, pound for pound. Since farming spiders is incredibly inefficient, scientists have been trying for decades to find a way to mass produce the material from genetically modified bacteria, yeast, and even goat milk, but these efforts have always fallen short. The biggest challenge was that the genetic information for dragline silk is a long string of repeating DNA, and, in previously tested organisms, cellular machinery arbitrarily alters or chops up such DNA sequences. To circumvent this problem, researchers precisely separated the repeating DNA into bits and inserted each repeating piece separately into bacterial genome. These smaller DNA pieces produced small peptides that ended up combining in bacteria and formed a strand of silk. The researchers also added to the end of each strand a chemical tag that glued the individual fibers together. This method was able to produce 2 grams of spider silk for each liter of bacteria and the resulting material behaved exactly like dragline silk. Its tensile strength was measured at 1.03 gigapascals, about the same as for naturally produced dragline silk. The engineered silk’s toughness measured 114 megajoules per cubic meter, compared with around 100 megajoules for silk made by spiders. And the engineered silk strands could stretch 18 percent before breaking, the same as natural dragline silk. The new silk was developed in part with NASA funding for applications such as giving astronauts a means of producing tough materials while on Mars. But the substance could be used in designing stronger materials for robotic, medical, or textile applications.

Electricity from falling snow

Ahmet A et al. All printable snow-based triboelectric nanogenerator. Nano Energy, April 2019.

Researchers have designed a new device with which we can now obtain electricity from falling snow. This new energy conversion method could become a new source of electricity in the future, especially in remote areas, as it does not need batteries. Researchers called it a Snow-based TriboElectric NanoGenerator, or Snow TENG. It is inexpensive, small, thin, and flexible like a sheet of plastic. After starting a charge from static electricity, energy is generated from the exchange of electrons. Snow is already positively charged by giving up its electrons, while silicone, a rubber-like material which consists of silicon atoms and oxygen atoms, is combined with carbon, hydrogen, and other elements to be negatively charged. When the positive-charged snow falls onto the surface of the silicone, the charges interact, and the Snow TENG captures the charge, which allows it to turn snowfall into electricity. 30% of Earth’s surface is covered by snow each winter, which is also the time when solar panels, one of the most reliable renewable sources of energy, aren’t very effective. Snow accumulation reduces the amount of sunlight that reaches the solar array, which makes them unable to operate. Snow TENG could be integrated into solar panels and provide a continuous power supply, even at a time when it’s snowing. Researchers used 3D printing to design the small device. It consists of a layer of silicone and an electrode which can capture the electric charge. Given that silicone is widely used in the industry, this method could dramatically reduce the global costs of producing electricity.

As science develops further, the “veils” of the universe are lifted and humanity can explore realms beyond which our senses would normally allow.

We are conscious beings and we seek answers to our existence. People search for answers to questions like, “Who am I and why do we exist?” The sciences reveal that existence is full of meaning and purpose. However, judgmental values and beliefs enter the process; restrictive and ideological approaches lead to confusion during man’s voyage to truth.

Take the question of how we exist. Different perceptions have their own point of view and reach different conclusions. While a materialist person accepts the matter to be eternal, for some the theory of evolution has all the answers; yet on the other hand, a person of faith explains existence with creation. Therefore a materialist, an evolutionist, and a believer struggle to reach a common conclusion.

Human vision is somewhat veiled; the things that are not witnessed are considered unknown. The events of both the micro and macro cosmos are veiled to us. Yet the more our science advances, the more of these worlds we begin to see. We understand how complex existence is, while also appreciating how majestically it has come into being.

Can senses and observations guide humanity to the truth? Our strongest senses are seeing and hearing; however, these senses can only perceive a narrow band of the electromagnetic spectrum. The human eye can see the wavelengths in between 4,000-7,000 angstroms; the ear can hear frequencies in between 16-20,000 Hz. When we rely only on our senses to understand and comprehend existence, the things that are outside our ability to see or hear become absent.

Dimension and distance are very important for vision. The dimension that humans can see with the naked eye starts at the millimeter scale; in perfect conditions, we can barely see beyond 18-25 miles. Things at dimensions much smaller than a millimeter and at considerably longer distances remain out of our visual range. A microscope brings the small dimensions into our visual spectrum and the telescope does the same for long distances. Before the invention of these devices, humankind was not aware of things such as the atom, molecule, galaxy, nebula, or black hole. Today, because of scientific advances, as we get closer to seeing things on the nanometer dimension, we are newly discovering structures at this scale and the laws that are effective here. The inner makeup of the atom has not yet been elucidated; our knowledge is based on certain theories and experiences. Our information regarding the universe is also limited. It is considered that in an expanding universe, according to the expansion velocity of galaxies and gravitational force calculations, the amount of visible matter only corresponds to 4% of the total mass of the universe, the rest estimated to consist of 26% dark matter and 70% dark energy.

When the true nature of things (objects, existence) that are unknown or seem to be simple are explained through science, the truth is found to be very different. From space, the earth looks like a small and pale blue dot. After getting closer, at first the oceans, continents, and major mountain ranges start to appear. There is not any indication of people or other organisms on earth yet. However, after looking closely enough, it is observed that earth is filled with numerous life forms.

We witness the twinkle of countless stars when we gaze at the sky on a dark night. These stars, each shining as a small spot, may seem insignificant. When we turn our telescope towards one of these spots, we face a giant star or a galaxy that houses billions of stars; we become astonished. And when we take a better look at these stars, some of which are colossal, we witness interesting events. In these thermonuclear cauldrons that are utilized like millions of atomic reactors, enormous amounts of energy are released into space after being produced each second under immense pressure at temperatures reaching millions of degrees. Humans should think for a while and be amazed by these things. The power required is immense and they last millions of years.

People can also observe the wonder of the universe by delving into much smaller dimensions (the micro world). Here, we witness the creation of wonderful beings and the employment of tiny creatures in vital tasks, even though this micro world is hidden secret from the naked eye. For instance, in the thousands of small chemical factories fitted in a seemingly plain leaf, sugars are produced from carbon dioxide and water via sunlight; nutrients are synthesized from various minerals in the soil and stored in the fruits, seeds, and roots of plants to serve as nourishment for the living.

The biological structure of a human body is built by the proliferation of a fertilized single cell, called a zygote, through division. More than 200 different cells executing very unique functions in tissues such as the brain, liver, kidneys, muscles, and bones are created from a single cell. Cells have specific structures and tasks according to their types, each housing various work benches and laboratories. For example, the make-up and function of a brain, liver, or muscle cell is very diverse, each shaped for their assigned task. The organelles inside the cells are also specialized; the job of one cell type cannot be completed by another. The molecules, secreted enzymes, and hormones synthesized in cells are different. While a pancreatic cell secretes insulin and glucagon, a thyroid cell releases thyroxine. Various dimensions and models of protein, hormone, enzyme, and antibody molecules are formed with structures called ribosome to be employed in unique processes. The energy that cells need is generated in organelles of mitochondria. In addition, various transmission lines, communication networks, and defense mechanisms are established inside cells.

Organs are not just packs of meat. Billions of cells in each organ are completing their works around a common goal. In each organ and cell, micro factories and laboratories of microscopic dimensions are set up, micro-machines and robots are being utilized, and atoms and molecules are employed like conscious workers.

The entire body is formed by the specialization of this zygote into very diverse cell types during the formation of these organs. The set of tasks in different organs is programmed to sustain the life of a single organism and to serve a common goal. How could one not be amazed by the combination of trillions of cells in a way to serve one purpose, form a body, and distribute tasks to different organs?

It is also important to analyze the composition of atoms and their relations with each other for a better understanding of the facts of creation. Different atoms form with varying numbers of protons, neutrons, and electrons in their atomic structures. A different element is generated when the proton number is changed; an isotope of the same element is generated with the replacement of the neutron number. Millions of types of molecules with unique features can be made via different combinations of atoms. Molecules are the smallest units that determine the chemical properties of matter. While the simplest compound is the hydrogen molecule, formed by two atoms, there are also molecules composed of millions of atoms.

There are molecules of diverse types and sizes present in the universe. Each molecule type is constructed in a three dimensional and unique way. The number, order, and shape of the bonds present among atoms in a molecule, even the angle between atoms, is very important. Because of these differences, despite the fact that they both contain a carbon atom, a diamond and graphite (coal) are distinct substances. The carbon atom can miraculously form 1,700,000 types of compounds on its own. Just as in hydrogen peroxide (H₂O₂,) and water (H₂O) molecules, a change of an atom in a molecule can alter the entire property of that particular molecule. A small change taking place on a single base sequence of the DNA chain may disrupt its condition leading it to be ineffective or cause a disease.

As humans, we only observe the tangible side of such materials. Yet the universe contains multitudes that we cannot detect or know. Just like a software composed of commands is required for computers and electronic devices made up of physical elements, the presence of an intangible world that is dominated by souls and commands undetectable by senses is necessary within the matter where the program of fate is operated.

As mankind accumulates knowledge about the universe and existence, we notice that not only do we have a greater understanding of the nature of things, but also that each dimension in existence is a veil and this veil is lifted with science.

“It’s very hard to grow a tree,” he said. “Just like it’s very hard to grow a person.”

“Well” my brother said, “if you and mom could grow me, I can grow a tree.” He was eleven at the time.

By the end of the summer, only one of his sprouts was still alive. He’d forgotten what kind of tree it was – in his enthusiasm, he hadn’t time for labels. On a Sunday in early September, after church, my family went out to our backyard with hand shovels and a rake. On our hands and knees, we took turns digging in the soft, wet earth. It was a warm day, and the late-season sun spilled like gold filigree through the leaves of our large oak tree. My brother and father, rich earth worked into the fissures of their hands, tenderly planted the sapling. I could tell, by my father’s face, that he didn’t give the tree a chance. But my brother believed completely, and when the planting was finished to his satisfaction, he stood and said a prayer, a brief benediction and blessing for our house.

He spent that autumn tending to the sapling. He would water it daily, and measure its progress with a ruler. Against all odds, it continued to grow.

So, too, did my brother. As the years passed, and the tree grew thicker, my brother grew taller. He fell in love, had his heart broken, lost his way. By the time he left home, seven years later, the tree had grown into a healthy, albeit small, tree. It had claimed its unceremonious space in our backyard. But it hadn’t borne fruit, and we had mostly forgotten to notice that the tree was there. We still had no idea what kind of tree it was.

“A defective tree,” my father said one night, bitterly. “A tree incapable of growing fruit.” My brother had been gone a year then, and we heard word of him sparingly – a postcard from Louisiana, or a phone call from a hotel in Oklahoma. I left home the next year. I took my first trip to Paris, where I fell in love with the city, and a woman, my future wife. Another year passed, and my brother and I did not speak.

When I received word that my brother had died in a car crash in Texas, I was living in the south of Spain with my wife. She was pregnant by then, a small sapling growing inside her, and when I hung up the phone on my father, the first thing I thought of was what my brother had said all those years before: There’s a whole tree in this little seed. I looked at her and thought: There’s a whole person in this little seed. Then, naturally, I cried.

It was late June. We arrived in Philadelphia just in time for the funeral. It was a small affair at a church outside the city, on a small plot of land overlooking a creek. The grave had already been dug, the fresh earth piled high beside it. I remembered my brother’s small hands, their crevices grooved with dirt. Afterwards we returned to our house. It had grown quiet in the years since my brother and I had left, and my parents would soon sell it.

That night at dusk, my father took me out to the backyard. “I have something to show you,” he said. We walked barefoot through the grass, the cicadas murmuring in the dense, sultry summer air. When we got to my brother’s tree, I noticed something moist and wet beneath my foot. I knelt down. It was a plum. There were plums all over the ground, and more on the tree.

“It’s the first year it blossomed,” my father said. “I couldn’t believe it.”

We roamed through the gloaming, prospecting the luscious, purple globes from the low branches, biting into the soft flesh, the juices spilling down our chins. They tasted good. As I ate, I picked out the seeds, put a few of them in my pocket. They came with me on the plane back to Spain. I planted them in cups all over our house, much to my wife’s amusement. I watered them diligently, checked them daily for growth. When we planted one of the seedlings at the end of the summer, my wife’s stomach was already large, and while I worked in the earth, she sat on our porch and watched. “It will never grow,” she called out to me. “Seedlings never grow.”

As I write this, our son is playing in our backyard, his small, growing body shaded by the small, growing branches of a plum sapling.

When a professor of Turkish language and literature is met by Turkish hospitality during a short stopover, she realizes how much the world is in need of small

I was sitting at my desk, listening to professor Adalet’s lecture on Turkish morphology. It’s was my third year in the undergraduate program and I loved my major; Turkish language and literature. The university I attended, though a modest one, was the best of the state universities in my country, Albania.

Adalet Hodja—that’s how we, her students, addressed her in Turkish—was a lovely lady, passionate in teaching, and proud of her Turkish heritage. From the first day she came to our country, she traveled to all major cities photographing everything unusual that caught her eye. She was most fond of the Ottoman prints in architecture, cuisine, cultural customs and the Albanian language.

To make her lectures enjoyable, she used to season them with interesting anecdotes from daily life or with jokes from Nasreddin Hodja— a funny Turkish folkloric figure, also well known by Albanians. Even at times, she used to relate delicious recipes from south eastern Turkey where she came from.

That day, the long discourse on how the words in Turkish have changed forms from past to present was about to lull us into sleep when Professor Adalet, very wisely, dropped the topic and started relating to us something special that had happened to her.

“Years ago, we were traveling from Erzurum, an eastern city where my in-laws live, to Bolu, a cute city in the Black Sea region where my husband and I worked as instructors at Abant University. My husband was driving, and I was trying, as hard as I possibly could, to keep our three children entertained. It was a hot summer day, and traveling crammed inside a small car wasn’t the best way to spend it. The children were getting hungry, so I proposed a break. Judging by the road signs, the closest city where we could find a decent restaurant was two hours away, and since my children were growing impatient, we decided to stop at the first çeşme (a water fountain by the road).”

“In Turkey, such water fountains are built by philanthropists,” Adalet hodja explained.. This made sense, considering even a cup of coffee is cherished for 40 years in Turkey, so building a water fountain to satisfy the thirst of people was a greater, more cherishable deed.

“Not long after that, we saw a çeşme by the side of the road. A big oak tree nearby was shading the flow of water, a vast field was covered in clovers, three cows were grazing, and a white stucco house was gleaming under the sun at a distance… What could be more inviting?

We got out of our car and after washing our hands with cold water, we sat down on clovers under the tree, feeling refreshed.”

Adalet hodja took a deep breath with unmatched pleasure, as if she was extracting the air of that summer day from wherever it was stored in space and time.

“I was about to lay out the picnic table cloth and the food we had taken for the trip, when I noticed a woman hurrying toward us from the white house. Her dress, her headscarf tied from behind, her sunburned face, all spelled local.

“We felt a little uneasy sitting on a property without asking first, so I readied myself to apologize. When the woman got closer, we noticed that she was carrying a tray covered with a clean white cloth.

“‘Welcome!’ she said with sheer delight before I could mutter my apologies, and then handed the tray to me in slightly embarrassed manner.

‘We would like to invite you in,’ she said pointing to the white house, ‘but my husband and his brothers are painting the house today.’

“‘Please, forgive us;’ she said timidly. You are Tanri misafiri (a guest sent by God), and I wish we could have properly accommodated you. Please pardon us,’ she said apologetically and left the tray in my hands kindly wishing us to enjoy our meal.

“I thanked her in return in the way most pleasing way, saying ‘Allah razi olsun,’ may God be pleased with you.

“I opened the tray to discover fresh baked pita bread, still warm and plump, and juicy white grapes.”

Our teacher swallowed hard to keep the tears but I was pretty sure she must have wept then, holding that tray.

“I swear to God,” she concluded, “only food from paradise would have tasted that good.”

She looked at her watch and declared the class dismissed. I looked around and saw that my classmates were deeply impressed with her story as well.

Generosity and hospitality were prevalent, highly esteemed values among Albanians, too. We were happy to see that small acts of kindness were appreciated elsewhere. It is after listening to such stories that you say to yourself: “With good people around, the world is a nice place to be.”

Why is this surface area so large? What could the wisdom behind it be? Tiny endoplasmic canals play a role in inner cell transportation and distribution of matter. ER is the organized industry district in the cell. Most of the factories of molecules produced by chemical reactions are found here. ER is the production spot in the cells of proteins and hormones. Consequently, a broad surface area is very necessary and important.

Different degrees (pH) of acid are necessary for each reaction. However, because the acid necessary for one reaction can negatively affect the other reactions, thousands of opposite, intricate and different reactions take place. For this reason, membrane surface areas need to be wide. Sometimes hundreds of protein molecules are produced in just a second in a cell. The rapid and flawless lining up side-by-side of tens, hundreds or thousands of amino acids can only be achieved with a knowledge and power that surpasses these very small structures.

Wrapping the inside of the cell like a web and forming a buffer against mechanical effects, ER is responsible for establishing the flexibility and soundness of the cell. In muscle cells, ER takes the name Sarcoplasmic Reticulum (SR), which has a very important duty in the contraction of muscles. The size of the surface area of SR in the muscles of the structural frame is proportionate to the speed of muscle contraction. Consequently, there is more SR in muscle cells where there is rapid contraction. SR also serves as a calcium depot in muscle cells. Normally calcium is a deadly poison for the cell, and for this reason it is kept out of the cell. The concentration of calcium outside the cell is 10,000 times more than it is inside the cell. However, SR stores calcium in the cell in its own body. Thus, it both prevents the cell from being harmed and it provides the necessary calcium for contraction.

ER has the duty of eliminating the poison in the liver cells from the body by means of gall. For example, jaundice-causing bilirubin is a deadly poison for the brain especially in newborn babies. If jaundice is not treated, motor loss (paralysis) and intelligence loss can result from brain damage. Bilirubin and glucuronic acid combine by means of some enzymes on the surface of ER in the liver and are thrown into the gall bladder. In this way ER plays an important role in making foreign matter harmless and in reducing the side affects of medications to a minimum. Babies’ sensitivity to some medications during the first three months of life is due to ER’s not yet being developed enough to eliminate their harmful effects.

If it is taken into consideration that all of these mechanisms exist in human, animal and plant cells, it can be clearly seen that a broad and complex structure in such a small volume and its many functions can only have been placed there by the All-Powerful whose knowledge, wisdom, artistry, will and power permeate every moment and every spot.

Celaloglu is a freelance writer from Turkey with a degree in biology.

Mosquitoes like climates with high humidity and rainfall. While a single raindrop can weigh 50 times as much as a mosquito, how can mosquitos fly and survive under what seems to be a devastating weather condition for them? Andrew Dickerson and co-workers at Georgia Institute of Technology examined the effects of falling raindrops on the flying mosquitoes using high-speed video capture and found that rain does no damage to flying mosquitoes. Upon impact with mosquitoes, the raindrops do not splash and scatter but they merely deform and hold together. This was calculated to be due to the small diameter and the velocity of the drop. On the other hand, given the relatively small mass of the mosquito, the drop does not significantly alter its speed. A partial hit on the mosquito by the falling drop causes the mosquito to rotate around its flight path. Mosquitoes were found to easily recover and resume their flight immediately after the impact. In the case of a direct hit by a raindrop, the mosquitoes were still able to literally separate themselves from the drop after traveling with the drop for a while without lethal damage and resume flight. The researchers further analyzed the impact force of the raindrops on the mosquitoes and found the direct impact to exert around 80 times the gravitational force. This is an extremely high force for larger organisms however, for mosquitoes with a very strong exoskeleton, this turned out to be a minor fraction of 1500 X g, which the researchers tested the mosquitoes and found them to be still able to fly! The outstanding resilience of such a small organism already inspired scientists to start designing very small robots that may serve as airborne search-and-rescue vehicles. But scientists are still very much limited by the basic factor of how small they can go.

What exactly happened in AD 774?

Researchers in Nagoya University of Japan have recently discovered a cosmic mystery when they were analyzing the growth rings of two cedar trees that are as old as 1200 years. All trees are known to incorporate particles from the atmosphere during photosynthesis. Carbon-14 (C14), one of the exceptional elements in the atmosphere, is generally formed by massive solar flares or by supernovae and it is present in very low percentages. Interestingly, researchers found that the cedar tree ring produced during the growth season of AD 774 had about 1.2% more C14 than in the previous years, that is about 20-times more than the usual range of 0.05%. These results indicate that some cosmic event during AD 774 generated a major influx of radiation leading an excessive amount of C14. Only a massive supernova explosion might have been strong enough to create this much radiation. However, if this was a supernova, we should either be able to catch the traces with modern telescopes, or find historic documents reporting this extraordinary cosmic event. But, we simply have no record of anything unusual happening in our skies in that period. Alternatively, a massive solar flare might have created such a radiation. In fact, 13th-century English chronicler Roger of Wendover mentions a cosmic event that could possibly be a solar flare. However, a flare with that magnitude would have been the biggest solar flare ever recorded by our sun and probably would have destroyed the Earth’s protective ozone layer leading to disastrous ecological consequences. Thus, the flare hypothesis seems also unlikely. By now, scientists are only positive that some very energetic event occurred in 774. But what exactly was it? Frankly, their guess is as good as ours.

Digestion in grain-eating birds

The digestive system of the chicken, which is a representative of the world of birds, is comprised of organs lined up in straight line succession: a beak, mouth, gullet, craw, front stomach (with gland), gizzard, small intestine, caecum, large intestine, cloacae and anus. In addition, enzymes secreted from the pancreas, liver and gallbladder also have digestive duties. Ending in a sharp point, the beak was created especially to be able to pick up single pieces of feed. Chickens do not have assisting organs like the palate, cheek, tongue or teeth that are normally found in the mouth, the first door of digestion in most animals. Ruminating animals like cows, sheep, goats and camels use the tongue instead of a beak for taking food into their mouths, and then their teeth are used to begin the breakdown of food. In chickens, however, this breakdown is initiated with the bottom and top beak. In ruminants there are taste buds in different shapes on the tip, sides and middle of their tongues which also function as the organ for the sense of taste. Since such taste buds are not found in chickens, there is also no perception of taste like that experienced in ruminating animals.

The structure and function of the gullet, or food pipe, has similar characteristics in chickens and other animals. However, just as in all birds that eat single seeds and grains, there is another digestive organ in chickens in the shape of a bag opposite to where the gullet expands. Called a craw, this tiny pouch is a place for the storage, wetting and softening of feed, and it serves the purpose of bringing food to the consistency needed for further digestion; consequently, it lightens the burden of the stomach (just like when we leave food that is difficult to cook, like chick peas or beans, standing in water overnight before we cook it).

A chicken’s stomach is composed of two different sections, the front stomach and the gizzard. The feed the chicken eats passes from the gullet and the craw to the front stomach, where digestive secretions are made. The food is stored here briefly and mixed with the special fluids of the stomach. Found in this secretion are both the pepsin enzyme, which starts the digestion of proteins, and hydrochloric acid, which is secreted to generate the pH level that makes this enzyme effective (and which also helps in the dissolution of minerals). These two important secretions are produced by different glands in the stomach. Like the craw, the gizzard, which comes after the front stomach, is the place where mechanical digestion, which is particular to all birds that eat grains, takes place. The gizzard is called the stomach with muscles because it is comprised of a pair of thick and strong muscle layers. As a result of these muscles constricting strongly, feed is broken down mechanically and ground up. While gathering feed, the chicken usually also swallows small pieces of sand, stone and limestone as if it knows how its digestive system works. Although many of us think that chickens swallow stones because they cannot distinguish them from feed, it is obvious that there is a purpose why they are doing it. If these stones, which are like “mill stones” for the digestive tract, are not found in the gizzard, the feed is not fully ground; consequently, it will pass to the small intestine in a form that will not be fully beneficial to the body.

Depending on its characteristics, the feed eaten can stay in the gizzard for a few minutes or several hours. The small intestine, which comes after the stomach, is comprised of the duodenum (twelve-finger intestine), the jejunum and the ileum. The small intestine is similar in grain-eating birds to those of other animals. The duodenum empties the secretions coming from the pancreas and the bile coming from the gall bladder. The digestion and absorption of the feed actually takes place in the small intestine due to these secretions. Final digestion and the absorption of carbohydrates and protein are effected by bacteria found at the point where the small intestine ends, in the 10-15 centimeter-long, V-shaped caecum.

The large intestine and the cloacae are found in the advanced sections of the digestive system. The role of the large intestine, which is twice as large in diameter as the small intestine, is to temporarily store the waste from the digested food and to maintain the balance of water in the body. The cloacae is a small orifice with a structure formed by the widening of the large intestine towards the anus and where the digestive, defecation and reproduction tracts open up.

While giving grain-eating birds the above mechanisms in order to nourish them, God equipped ruminating animals with different oral, dental, gastric and intestinal structures as well as different digestive strategies.

Digestion in ruminating mammals

While secreting saliva is essential for ruminating animals, it is not necessary for chickens because of differences in their digestive system. As a result of the secretion of saliva the fodder of ruminants is softened and dryness of mouth is prevented. Ptyalin (or alpha amylase), which is found in saliva, has antibacterial properties that protect animals from infections in addition to playing a role in digestion. The mother cows constantly licking their newborn calves is both an expression of compassion and also of wisdom in protecting the newborn from probable infections (Similarly, animals like dogs and cats licking their wounds and thus speeding up healing is no coincidence, but a sign of universal wisdom and mercy). This wisdom shows that saliva, of which cows secrete 90-180 liters and sheep 5-8 liters per day, is not a waste.

The stomachs of ruminants are comprised of four sections; the first three are the rumen, the reticulum and the omasum. These three sections are called the front stomach. The section that does the real work is called the abomasum. Because the nutritional value of grass is very low in comparison with meat, it is obvious that a large bodied ruminant will need a lot of grass. Consequently, the capacity of rumen being 150 liters is a wise and fitting design. In addition, the cellulase enzyme that digests the cellulose walls in plant cells is not produced in the tissues of any mammals. The possessor of infinite knowledge and power, God placed high concentrations of bacteria, protozoa, yeast and fungus-all of which can produce the cellulase enzyme needed to break down cellulose-in the rumen of ruminating mammals. The rumen acts as a fermentation factory because of these microorganisms. Breaking down the cellulose-rich food consumed by ruminants, these microorganisms both fulfill their own nutritional needs and help to meet the host’s energy, protein and vitamin (especially B12) needs within a symbiotic relationship. I wonder where the microorganisms in the rumen learned about this synthesis and assistance mechanisms!

What a magnificent engineering wonder is the “sulcus esophagus,” a semi-duct structure in the shape of a canoe that extends from the end of the food pipe in newborn ruminants to the abomasum where the essential stage of digestion takes place. Due to this structure, milk drunk reaches the last stage of the stomach without passing through the rumen, for there is no matter like cellulose in the content of milk that needs to be broken down. Consequently, there is no need for the milk to go to the rumen. If it were not like this, the milk would go directly to the rumen where it would be ruined by microorganisms, lose its nutritional quality and be like a bribe given in vain to the microorganisms in the rumen.

While discussions on the education of creation in schools continue, generations grow up with lack of knowledge about the Creator and understanding of His Actions. The current education system in high schools and colleges are giving knowledge about the universe, nature, earth, and life but courses are not directed to understand the Actions of the Creator. How and where can people learn about their Creator? Although there are various means such as the internet, religious groups, and journals, it is not always feasible and enough to understand directly the Creator’s Actions without a good understanding of sciences. Fortunately, every science continuously mentions God with their unique language and speaks of the Creator, but we will need a point of view, windows to see beyond our sight and knowledge, just like we need a microscope to see microorganisms or a telescope to discover depths of the universe. With some attention, everyone can understand what sciences reflect from God’s Actions. That’s why we should listen to what sciences tell us in their own language.

Imagine there is a simulation program to analyze a car crash. In this program, let us say you enter different parameters such as velocity, weight, angle of hit, general structure of the car, hardness of the body, and weather information like wind velocity and its direction and so on. After you click on the OK button in this imaginary simulation program, you almost get the same results with real physical crash tests. This obviously shows us a skillful software programmer and his great knowledge in mathematics and physical events. Noticeably, nature is composed of millions and millions of parameters determining final result just like this simulation program. For instance, when you throw a stone to a lake or into water, first of all it falls down with a velocity and then you see a wave of water expanding to its surrounding from the center affected by that velocity. The velocity of this stone at a certain time and place and wave formation on the surface of water can be explained with some physical laws described with mathematical equations. Whoever put these rules for the physical events also created the universe in a perfect mathematical order. From these and the knowledge we get from computer sciences, physics, and mathematics, we can open windows to understand the ruler of the universe as Glorious Creator.

We are at the time of great advancements in gene technology and huge increase in knowledge about molecular biology; even individual structures of biological molecules are known and many more discovered about cellular mechanisms. The more we learn, the more we face complexity and organization in the tiniest compartments of cell. Cell is no longer a small room filled with a gel-like structure in our minds, it is a massive factory that contains all required machinery and it is automatic, well balanced, and continuously renewed. Things are in constant motion; uptake follows release of substances and signal from outside results in a response produced inside. With increase in understanding of how living things are working and necessity to answer how these things originated caused discussions in scientific research. Some scientists like to talk only at scientific platforms or on so-called testable scientific subjects, but this does not change the reality. We wonder about the beginning and we wish to live forever. We are finite but dream of infinity. How can we think of eternal life if we were a product of something that is not eternal?

Imagine there is a high-tech, but small self-working factory producing highways and trucks to carry items, fuel engines for the energy that can be used in many different processes and containing solar energy collectors. There are great photocopy machines for the production of a new factory, feedback systems to control and repair any problems as well. Without any concern, control of all these events and thousands of machines, engines, highways in such a small sized factory without any problem involves a perfect engineer, scientist, architect, and chemist. Similarly, believe it or not, the cell is an excellent composition of around one million molecules, thousands of machines, and energy producing engines. There are highways, trucks, feedback systems and more in an arranged and fine control in such a small size. Mitochondria, for instance, is one of the most essential cellular organelle and produces ATP molecules as carrier of energy obtained from organic molecules for energy requiring cellular processes. In addition, cellular requirements vary by time and vesicles carry required molecules as cargo on molecular motors using microtubule pathways to different places. Those and many other examples we learn from biological sciences point to the Glorious Creator of the Earth.

When you consider a cell coming into existence by causes other than the hands of a Creator with numerous levels of regulation, coordination of subcellular compartments like organelles, information storage in DNA, and use of this information required for their specific function, it means molecules come together under the effect of natural causes and form an artistic cellular structure in a wise-manner. Actually, this reminds us of a very famous experiment by Stanley Miller to make amino acids, the building blocks of proteins, to demonstrate that life on earth has originated by natural causes and chance. Miller, in his experiment, took molecules which were supposed to represent the major components of the early Earth’s atmosphere and put them into a closed system. He used methane (CH4), ammonia (NH3), hydrogen (H2), and water (H2O) in his experiment and ran a continuous electric current to stimulate lightning storms and to drive these unfavorable reactions. He found that three amino acids have been synthesized in these conditions. Later, it was found that this composition was different from the early Earth’s atmosphere and arguments raised to his experiment due to continuous energy input not possible in nature. However, this was exciting at that time and some used headlines like “Miller created life.” On the other hand, what Miller had managed to synthesize was only a few inanimate lifeless molecules.

People who do not believe in God also do not believe in creation. That’s why they tend to conclude that “nothing is created out of nothing, and nothing goes to nothing; there is only composition and decomposition.” But, the All-Powerful One has two ways of creating. The first way is through origination and invention and the second way is through composition and through art. He creates from out of nothing together with everything necessary for, again, nothing. In the second way of creating, He forms beings from materials of universe in order to show his delicate wisdom, perfection, and the manifestations of His Names. “O people! be careful of (your duty to) your Lord, Who created you from a single being and created its mate of the same (kind) and spread from these two, many men and women…” (Quran 4:1)

When we think about the lessons learnt from these examples and natural sciences with their special focus areas, we realize that every science somehow declare the Glorious Creator of this universe. However, there may not be an opportunity in school to discuss and go deep into the understanding of the Actions of the Creator. With the window of what sciences open to us about God, we can uncover the hidden truths.

Ali Fethi Toprak is a PhD candidate at Southwestern Medical Center, Texas University, Dallas.

In the 21st century, we are plunging forward into a new era of technological power — one that offers enormous promise and danger.

What is nanotechnology?

In its most basic form, nanotechnology refers to the manipulation of materials at the atomic or molecular level. The name derives from the nanometer, a scientific measurement unit representing a billionth of a meter, three to four atoms wide. Scientists are learning how to connect atoms and molecules together to create nano-scale mechanisms that create switches or transistors, or even small machines that can perform complex tasks.

To use an oft-quoted comparison, a human hair is between 100,000 and 200,000 nanometers thick, while a typical virus can be just 100 nanometers wide. Atoms are typically between one-tenth and one-half of a nanometer wide. Due to the difficulties involved in working at this scale, manipulation of items as “large” as 100 nanometers is generally included in the concept of nanotechnology.

Nanotechnology enables scientists to create new materials atom by atom. With increasingly more powerful microscopes, scientists can see molecules that are mere nanometers (billionths of a meter) in size. To clarify this size, a pinhead is one million nanometers across. The field intertwines nearly all fields of science.

Most nanotechnology discussions deal with the futuristic concept of nanomachines or nanorobots: microscopic devices that carry out tasks at the atomic or subatomic level. Nanotechnology, also called molecular manufacturing, is “a branch of engineering that deals with the design and manufacture of extremely small electronic circuits and mechanical devices built at the molecular level of matter.” The goal of nanotechnology is to manipulate materials at the atomic level to build the smallest possible electromechanical devices, given the physical limitations of matter. Many of the mechanical systems that we know how to build will be transferred to the molecular level as some atomic analogy.

A typical vision of the twenty-first century: “Nanotechnologists will be building our cars one molecule at a time, invading our bloodstream to declog our arteries, and replicating themselves thousands of times over.”

Nanorobots (1)

A nanorobot is a computer-controlled robotic device constructed of nanometer-scale components to molecular precision, usually microscopic in size (often abbreviated as nanobot). This reminds one of the 1966 film Fantastic Voyage, in which a team of scientists (including Raquel Welch) are miniaturized, placed in a tiny submarine, and injected into a sick man’s bloodstream. Nanotechnology invariably involves work on a much smaller scale than the average blood cell.

Producing commercially viable nanomachines will be more challenging, since atomic manipulation, while not theoretically contrary to the laws of physics, is still extremely slow and costly. The most widely discussed long-term solution is to make the nanomachines self-replicating. Control mechanisms for such systems, mainly how a machine “knows” to copy itself and when to stop doing so, are still in their very early stages. Once again, theory is far ahead of practical reality.

Many of nanotechnology’s more recent practical applications have been in the area of material research. However, scientists believe that transistors eventually could be built in this way, paving the way for computational technologies that do not depend on silicon and that can pack even more circuitry into microscopic spaces.

Nanoshells (2)

Nanoshells, defined as tiny particles that can manipulate light, can be used to transform medical procedures, ranging from cancer therapy to medical testing and drug delivery. They are ideal for biotechnology applications because they are biocompatible, can be altered and modified, and absorb light easily in the near-infrared region, where human tissue is most transparent.

Nanoshells can be tagged and delivered specifically to tumor cells, thereby leaving healthy cells undamaged. In addition, they can reduce the amount of time needed to conduct medical tests from several days to a matter of seconds. When incorporated into temperature-sensitive polymers, nanoshells can be triggered to release a chemical using infrared light, thus enabling a patient to control the release of medicine that requires periodic dispensing.

A new bandage (3)

A new bandage that imitates natural healing process is used for injuries ranging from minor cuts to gunshot wounds. The bandage, a flannel-like material, stops bleeding immediately and eventually is absorbed by the body. This new material is developed by spinning a compound naturally found in the blood into a bandage that can minimize blood loss and be absorbed by the body, according to an article in the 12 Feb. 2003 issue of Nano Letters, a journal of the American Chemical Society. “We’ve taken an old technique — electrospinning — and applied it to natural fibers,” says Gary Bowlin, associate professor of biomedical engineering at Virginia Commonwealth University.

When a person bleeds from a cut or a wound, a blood clot forms and netting made of a substance called fibrin develops over the clot. According to researchers, fibrinogen, the compound in blood that comprises the “natural” bandage, is a fibrin precursor that can come from human, bovine, or genetically engineered bacterial sources. The goal is to pack the bandage like gauze so that it can be used to treat trauma patients, according to Bowlin.

Science fiction into reality (4)

Imagine a world in which cars can be assembled molecule-by-molecule, garbage can be disassembled and turned into beef steaks, and people can be operated on and healed by cell-sized robots. Sounds like science fiction? Well, with current semiconductor chip manufacturing encroaching upon the nanometer scale and the ability to move individual atoms at the IBM Almaden laboratory, we are fast approaching the technological ability to fabricate productive machines and devices that can manipulate objects at the atomic level. With this ability, we will be able to develop molecular-sized computers and robots that will give us unprecedented control over matter and the ability to shape the physical world as we see fit.

Nanofabrication techniques with applications in fiber optics, biotechnology, microelectromechanical systems (MEMS), and “tiny mechanical devices such as sensors, valves, gears, mirrors, and actuators embedded in semiconductor chips,” are of particular interest, as they are but a mere step away from the molecular machines envisioned by nanotechnology. MEMS are used in automobile airbag systems as accelerometers to detect collisions, and will become an increasing part of our everyday technology. In 1986, K. Eric Drexler, a researcher at MIT, foresaw the advent of molecular machines. In his Engines of Creation, he outlined the possibilities and consequences of this emerging field, which he called nanotechnology. Drexler has written numerous books on the subject, such as Unbounding the Future, and has founded the Foresight Institute, a nonprofit organization dedicated to the responsible development of nanotechnology. Today, nanotechnology research and development is widespread in numerous universities. The U.S. government has created an organization, the National Nanotechnology Initiative (NNI), to monitor and guide research and development in this field.

Potential benefits

It does not take much of a leap of imagination disassemblers dismantling garbage to be recycled at the molecular level, and then giving it to assemblers who will use it to build atomically perfect engines. Stretching this vision a bit, you can imagine a Star Trek type replicator that could reassemble matter in the form of a juicy steak, given the correct blueprints and organization of these nanomachines.

A laboratory-scale “in vivo nanoscope” could be capable of providing atomic resolution, real-time movies of happenings inside living cells in intact living animals. This nanoscope, a hybrid of conventional technology and early (pre-assembler) nanotechnology, is an enormous leap in the ability of biologists to understand the workings of cells and develop medical therapies.

Some of the more prominent benefits of nanotechnology would be precision manufacturing, material reuse, and miniaturization. Medical applications are pharmaceutical creation, disease treatment, and nanomachine-assisted surgery. Environmental applications lie in toxin cleanup, recycling, and resource consumption reduction.

Nanomedicine deals with the comprehensive monitoring, control, construction, repair, defense, and improvement of all human biological systems by working at the molecular level with engineered nanodevices and nanostructures; the science and technology of diagnosing, treating, and preventing disease and traumatic injury, as well as relieving pain and preserving and improving human health through the use of molecular tools and molecular knowledge of the human body; and the use of molecular machine systems to address medical problems and using molecular knowledge to maintain and improve human health at the molecular scale. Cosmetic nanosurgery carried out with simple nanomachines (no on-board computers, for example) could change hair color, cause hair to grow or not to grow in specific locations, keep teeth clean and skin smooth, and so on, all far more effectively than current treatments.

Looking somewhat further in the future at more radical modifications of the human body through nanotechnology, Edward Reifman describes dentistry with assembly-fabricated teeth, and even with the teeth and jaws being made of diamonds. “In the long term, we hope to be able to build small nanorobots which can search out and destroy cancerous tumors when they comprise just one or two cells” or “small drilling machines which dissolve clots.”

Viruses, which are natural nanomachines, could be fought more effectively, as the body’s own immune system has some handicaps: it tends to forget the shape of its enemies, cannot always successfully identify malignant cells, and suffers from a certain delay until the immune reaction is fully developed. Therefore, nanomachines could support the immune system. Nanomachines could rout bacteria, excise tumors, reconstruct damaged tissue, and even make a huge contribution to treating the process of aging.

Along with the obvious manufacturing benefits, there are many potential medical and environmental benefits. With nanomachines, we could better design and synthesize pharmaceuticals, directly treat such diseased cells as cancer, better monitor a patient’s life signs, and make microscopic repairs in hard-to-operate-on bodily areas. With regard to the environment, we could use nanomachines to clean up toxins or oil spills, recycle garbage, and eliminate landfills, thus reducing our natural resource consumption.

Potential dangers

The downside to these benefits is the possibility of using assemblers and disassemblers to create weapons, to be used as weapons themselves, or the possibility that they may run wild and wreak havoc. Other less invasive but equally perilous uses would be in electronic surveillance.

However, with nanotechnology, armies could develop disassemblers to attack physical structures or biological organisms at the molecular level. A similar hazard would be if general-purpose disassemblers escaped into the environment and started disassembling every molecule they encountered, the so-called “gray goo scenario.” Furthermore, if nanomachines were created to be self-replicating and, for some reason, had a problem with their limiting mechanism, they would multiply endlessly, like viruses.

Even without considering such extreme disaster scenarios, we can find plenty of potentially harmful uses for nanotechnology, such as the erosion of our freedom and privacy. For example, people could use molecular-sized microphones, cameras, and homing beacons to monitor and track others.

Ethical issues and analysis

Given the awesome potential dangers inherent in nanotechnology, we must analyze its potential consequences. Nanotechnology may never become as powerful and prolific as envisioned by its evangelists, but as with any potential near-horizon technology, we should formulate solutions to potential ethical issues before the technology is irreversibly adopted. We must examine the ethics of developing nanotechnology and create policies designed to assist its development while eliminating, or at least minimizing, its damaging effects.

Nanosensors(5)

A nanosensor is defined as a chemical or physical sensor constructed by using nanoscale components, usually microscopic or submicroscopic in size.

Nanotechnology brings science fiction into everyday life6 Nanotechnology’s more immediate future lies in its application in such sensors as electronic “noses” that can detect, for example, the presence of individual protein molecules in a blood sample. This involves a fingernail-sized chip with thousands of sensors, each set to detect a specific substance. It might even be possible to make these noses so small that they could fit on a needle. Then, there would be no need for a blood test, for a finger prick would be sufficient to allow a full blood analysis.

Nanosensors also will be of great value in producing new medicines, for they can effectively find active substances. So far, it has been possible to build this type of sensor one by one; the difficulty lies in integrating perhaps 100,000 of them on one chip.

Aging can be delayed by repairing human cells one by one. Unlimited computer power can be obtained by improved microchip performance. Global warming can be reduced by cleaning greenhouse gases out of the atmosphere with nanoparticles, and pesticides could kill insects without harmful byproducts. Creating artificial muscles and sensors, as well as nanocoating for metal, could increase power plant efficiency and potentially save millions of dollars a year for electricity generators. For example, we now have self-washing windows that repel dirt, thanks to their nanostructured surface.

Nanofluids (7)

On the medical front, researchers at Virginia Polytechnic Institute are developing magnetic nanofluids. They posit that magnetic particles attached to medicines, like those used in chemotherapy, can be concentrated on one part of the body by using external magnets on patients. 

Always clean clothing (8,9)

Imagine textiles that cannot be stained or wrinkled, that always maintain the look and feel of fabrics made from natural fibers. Imagine materials that are 100 times stronger than steel, but weigh only one-sixth as much. Nanofibers could be used in astronauts’ suits, moving with them as they work to give them greater flexibility in space, or to allow the disabled greater mobility by acting as extra muscles.

Imagine batteries that take up less than one cubic millimeter, but supply a medical implant with power. Imagine sensors, smaller than a pinpoint, that detect anything in extremely low concentrations, from specific antibodies to toxic chemicals.

A big splash of coffee leaves an unmistakable stain on an ordinary pair of trousers; on a pair of nanotextile trousers, it can be brushed off without leaving a trace. A titanium frying pan and the laser in a fairly modern CD player are both based on nanotechnology. By using nanotechnology, wall paint could automatically sterilize an operating theatre, filters could be used in water purifiers to automatically kill undesirable bacteria, and roofing tiles that convert solar light into household electricity could give way to reinforced self-repairing houses immune to all natural disasters “short of a large incoming meteor.(10)

Hence nano-technology is and will continue to become part of our everyday lives … sometimes without us even noticing.

Michael Crichton (11)

Crichton says “These organisms [self-reproducing tiny computers] will be created by nanotechnology, perhaps the most radical technology in human history: the quest to build man-made machines of extremely small size, on the order of 100 nanometers, or 100/billionths of a meter. Such machines would be 1,000 times smaller than the diameter of a human hair. Experts predict that these tiny machines will provide everything from miniaturized computer components to new medical treatments to new military weapons. In the 21st century, they will change our world totally.

“The potential benefits are spectacular: Tiny robots may crawl through your arteries, cutting away atherosclerotic plaque; powerful drugs will be delivered to individual cancer cells, leaving other cells undamaged; teeth will be self-repairing. Cosmetically, you will change your hair color with an injection of nanomachines that circulate through the body, moving melanocytes in hair follicles. Other nanomachines will lighten or darken skin color at will, removing blemishes, birthmarks and liver spots in the process; still others could cleanse the mouth and eliminate bad breath. Nonsurgical nanoprocesses could even perform liposuction and body reshaping. They will also repair knees and spines.

Living spaces will be transformed with self-cleaning dishes and carpets and permanently clean bathrooms. Windows will lighten or darken at will; programmable paint will change color. You can walk through the walls of your house, since they are composed of particle clouds. Your personal computer and your watch will be painted on your arm. Temperature-sensitive clothing will loosen when it gets hot, insulate when it gets cold.”

In the future, roving nanomachines will convert trash dumps to energy, solar nanomachines will be coated on the houses to generate electricity, and flexible nanomachines will provide earthquake protection. It may even be possible to move a house across the lawn on the backs of millions of nanomachines.

In 2003, nanotechnology is still very much in its infancy. However, such major corporations as IBM, Fujitsu, and Intel are funding this research. U.S. government investment has gone from virtually nothing only a few years ago to well over $600,000,000 per year in 2003.

At present, nonotechniques are being used to make sunscreens, stain-resistant fabrics, and composite materials for cars; soon, they will be used to make extremely small computers and storage devices. Pittsburgh based PPG Industries, Inc. is making self-cleaning window glass; the Westaim Corporation of Toronto is making nanocrystal wound dressings with antibiotic and anti-inflammatory properties. Currently, nanotechnology is principally a material technology.

Most experts predict that self-reproducing machines are only a decade away. Man-made, self-reproducing entities already have been released into the environment. The first of these, of course, were computer viruses. The first viruses were created as a game (“core wars”), a 1960s battle between mainframe programmers, each releasing a program into the other’s mainframe computer. Originally limited to specialists, hackers soon joined in. The growth of computer networking made rapid worldwide transmission possible. Computer viruses, worms on the Internet, have become an international threat to information and global business.

Scientists are witnessing some of the problems of self-replicating biotechnology agents. For example, a recent report indicates that modified maize genes are appearing in native maize in Mexico, despite laws against it and efforts to prevent it. This is only the start of probably a long journey to control this new technology. Laws have been passed to put hackers in jail; delinquent biotechnologists will soon join them. We need international controls to deal with self-reproducing technologies right now, whereas now there are essentially none.

Footnotes

(1) www.zdnet.com.au/newstech/enterprise/story/0,2000048640,20267134-2,00.htm

(2)www.rice.edu/projects/reno/Newsrel/2001/20010402_nanotechnology.shtml.

(3) www.smalltimes.com/document_display.cfm?document_id=5481.

(4) http://cseserv.engr.scu.edu/StudentWebPages/AChen/ResearchPaper.htm.

(5) www.nansosensors.com.

(6) Nino Simic, “Nano into Everyday Life.” www.oresundit.com/composite(1610).htm.

(7) Ryan Randazzo, Reno Gazette-Journal, 15 June 2002.

(8) www.agg.com/Practice/Nanotechnology_main.html.

(9) www.oresundit.com/composite(1610).htm.

(10) www.foresight.org.

(11) Michael Crichton, “Could Tiny Machines Rule the World?” Parade Magazine, 24 November 2002, pgs. 6-8.

Some nanotechnology links:

• www.about.com/nanotechnology (A search engine that compiles various sources and articles).
• www.jmtour.com (Professor Jim Tour’s research home page).
• www-ece.rice.edu/~halas (Professor Naomi Halas’ research home page).
• www.nano.gov (The National Science and Technology Council’s site for nanoscale technology, including information on federal initiatives). 

In his Models of My Life, social scientist Herbert Simon stated that science’s purpose is to find meaningful simplicity in the midst of disorderly complexity. Although the systems in nature and society seem to be very complex, we need simple theories to understand them. The key to finding these simple rules or principles, which Plato called perfect form and thing-in-itself and Kant described as a kind of untouchable essence behind physical things or systems, is mathematics.

Mathematics and social science

One of mathematics’ main challenges is its uses in social sciences. But does mathematics, which is considered rigid and restrictive and the best tool for explaining matter, have laws for human life? The latest studies in sociology, biology, and epidemiology show that such laws and meaningful patterns do exist and can be discovered. One of the great achievements of mathematics and physics in sociology is explaining the six degrees of separation (i.e., the small world) phenomenon.(1)

Almost everyone has met someone far from our home who is a friend of a friend. This is so common that it has become a clich: It’s a small world “ even though there are now more than 6 billion people. Even more surprising is the structure of social networks, the map of who knows whom, which shows that all people are closely connected.(2)

A social network is a collection of people, each of whom is acquainted with some subset of others. This can be represented as a set of points (nodes) denoting people, joined in pairs by lines (edges) denoting acquaintance, in a company, university, or even a global community. Social scientists have studied such networks, both empirically and theoretically, for at least 50 years.

A revealing experiment

One of the first and famous empirical studies was conducted in 1967 by Stanley Milgram, a Harvard psychology professor: the small world phenomenon. He asked: Starting with any two people in the world, what is the probability that they will know one another? In a large social network, although X and Z might not know each other, they might have a mutual acquaintance. Moreover, X might be linked to Z by a series of links. In other words, X knows a, who knows b, who knows c … who knows y, who knows Z. But how many intermediate acquaintance links are needed, on the average, to connect X and Z?

According to Milgram (3), this phenomenon raises the issue of a certain mathematical structure in society, one that often plays a part in discussions about history, sociology, and other disciplines. For example, during western Europe’s Dark Age, cities became isolated because inter-city communications broke down and thus severely limited the network of individual acquaintances. Thus, social disintegration was expressed in the communities’ growing isolation and people’s infrequent contact with non-local people.

Milgram asked his test subjects, chosen at random from Nebraskan and Kansan telephone directories, to get a letter to one of his Boston stockbroker friends. The letters were to be sent passing them from one person to another, but only if both parties were on a first-name basis. Since it was unlikely that the letter’s initial recipient and a Boston stockbroker would be on a first-name basis, their best strategy was to pass the letter to someone whom they felt would be socially or geographically closer to the stockbroker.

A moderate number of the letters eventually reached their destination. Milgram discovered that the average number of steps in this process was about six. This is usually considered evidence of the small world hypothesis: Most pairs of people, even in a very large population, can be connected by a short chain of intermediate acquaintances.

Milgram’s work passed into folklore and was immortalized in John Guare’s 1990 play Six Degrees of Separation, where Ouisa claims: Everybody on this planet is separated by only six other people. Six degrees of separation. Between us and everybody else on this planet. The president of the United States. A gondolier in Venice…. It’s not just the big names. It’s anyone. A native in a rain forest. A Tierra del Fuegan. An Eskimo. I am bound to everyone on this planet by a trail of six people. It’s a profound thought…. How every person is a new door, opening to other worlds.(4)

Watts and Strogatz used this model to explain the six degrees of separation in society- and nature-based networks.(5) Their model employs mathematical graph theory, which consists of nodes (people) and links (acquaintance). They modified the regular network, in which every node has short-range fixed number of connections, by adding long-range connections to the regular network to simulate the short path length between nodes. This model is now used in such areas as networks connected with biological metabolism, genomes, proteins, the Internet backbone, power grids, companies, and the stock market.

Research on social networks has helped health professionals understand how epidemics spread. Epidemiological models help them to predict how fast a disease will spread and to develop small world theory strategies to combat them, for scientists now realize that this social network property is a main cause for the outbreak of epidemics. This network offers a super-connected web of stepping stones for infectious diseases. After analyzing the social network’s structure, public health specialists can devise new vaccination strategies to slow or stop the epidemic. The small world theory also explains the rapid spread of news, rumors, fashions, and gossip.

Other types of systems show similar properties: networks of actors involved in the same movie, scientific collaboration networks of scientists who coauthor an article, and even the Internet, where millions of web pages are connected via mutual links. Recent research shows that in all of these networks, there are only a few steps between one node and any other node. The average shortest path between a network’s nodes, is 3.5 for the actor network and 9.5 for the scientific collaboration network. Despite the Internet’s more than 800 million nodes, there are, on average, only 19 steps between one web page and any other.(6)

Conclusion

The small world theory is a great success of the theory of complexity in nature and social life. It reveals an underlying dynamic of interconnectedness that expresses itself indelibly in who we are and how we think, behave, and communicate. Such close interconnectedness reveals one important fact for constructing a peaceful and beneficial world: There are no strangers, for everyone is one of our friends’ or neighbors’ friend or relative. The key element in understanding people is communication. Mutual love and good relations continue as long as we understand each other. We are loyal and faithful to the extent that we share our friends’ troubles, because ignorance only builds an impenetrable wall between us.(7)

Hasan Guclu is a doctoral student in the field of very large complex systems, such as computer networks, social networks, epidemics, and surface growth.

Footnotes

1. See, respectively, A. L. Barabasi, Linked (Perseus Publishing: 2002); D. J. Watts, Small Worlds (Princeton University Press: 1999); and M. Buchanan, Nexus (W. W. Norton: 2002).
2. D. J. Watts and S. H. Strogatz, Collective Dynamics of Small World Networks, Nature 393 (1998):440-42.
3. S. Milgram, The Individual In A Social World (Addison-Wesley: 1977).
4. J. Guare, Six Degrees of Separation: A Play (Vintage: 1990).
5. Watts and Strogatz, Collective Dynamics.
6. A. L. Barabasi, Linked.
7. F. Gulen, Pearls of Wisdom (The Fountain: 2001).