How does loneliness affect your brain?

Spreng et al. The default network of the human brain is associated with perceived social isolation. Nature Communications. December 2020.

A recent study found fundamental structural and functional differences in the brains of lonely people. Researchers examined the magnetic resonance imaging (MRI) data, genetics, and psychological self-assessments of over 40,000 middle-aged and older adults in the UK Biobank medical database. They then compared the MRI data of participants who reported often feeling lonely with those who did not. There were several major differences in the brains of lonely people which were primarily found in what is called the “default brain network,” a group of brain regions that are involved in inner thoughts such as remembering, future planning, imagining, and thinking about others. Detailed analyses of these regions showed that surprisingly, the default networks of lonely people were more strongly wired together and their grey matter volume in regions of the default network was greater. Moreover, bundles of nerve fibers called fornix that connects the hippocampus to the default network were better preserved in the brains of lonely people. These findings suggest that since lonely people are more likely to use imagination, memories of the past, or envisioning the future to overcome their social isolation they strengthen memory-based functions of their default networks through internally-directed thoughts and imagining social experiences. Loneliness has been increasingly turned into a major health problem, as other studies showed that older people who experience loneliness have a higher risk of cognitive decline and dementia. As COVID-19 related social distancing continues, isolation and loneliness could affect our society even more dramatically. Understanding how loneliness manifests itself in the brain at the structural and functional level, and how these paradoxical findings translate into late-onset brain pathologies, would be critical to prevent both neurological diseases and related social problems.

Human-made mass is about to exceed total global living biomass

Elhacham et al. Global human-made mass exceeds all living biomass. Nature. December 2020.

Humanity is rapidly approaching a new milestone in the history of our planet. The amount of manmade objects on Earth will soon outweigh all living biomass. A new study finds that each person alive today produces approximately the amount of manmade mass equivalent to their bodyweight every week. Our daily life objects such as roads, houses, cars, and clothes now weigh in at around 1.1 trillion metric tons, which is equal to the combined dry weight of all plants, animals and microorganisms on the planet. The production and accumulation of manmade objects, also known as anthropogenic mass, has accelerated since the early 1900s. The world’s plastics alone now weigh twice as much as the planet’s marine and terrestrial animals.

About 50% of the current anthropogenic mass is concrete. Bricks, asphalt, metals, plastic, and other materials make up about 19% of the total. Three major problems will arise from the outproduction of antropogenic mass. First, manufacturing consumes resources which will not be available for future generations unless objects are recycled or new raw materials are discovered. Second, even if we can achieve 100% recycling, pollution is generated and energy is used during manufacturing, so resources are still consumed. Third, many of the manufactured items will eventually be discarded which will cause serious disposal issues in the future. This is particularly alarming for the future. Nature is not infinite like so many of us would like to believe. If the current trend continues, anthropogenic mass will grow to three times the world’s biomass by 2040. In the next 20 years, we will generate as much waste as from the last 110 years together. These huge waste flows could lead to massive environmental catastrophes. This study demonstrates the brutal scale and impact of human activities on our planet. Humans are modifying the planet to such an extent that we might have already started a new geologic epoch likely called the Anthropocene.

Drug repurposing by artificial intelligence

Liu et al. A deep learning framework for drug repurposing via emulating clinical trials on real-world patient data, Nature Machine Intelligence. January 2021.

Researchers have developed a machine-learning method that analyzes very large datasets to discover which existing medications could work for diseases for which they were not prescribed. This process is called “drug repurposing,” a popular strategy to find new purposes for existing drugs that offers a rapid transition from research to clinical care. Drug repurposing can lower the risk associated with safety testing of new medications and dramatically reduce the time and money required to get a drug into the marketplace for clinical use. However, discovering new uses for existing medications still requires time-consuming and expensive randomized controlled trials to prove that a drug that is effective for one disorder will also be useful to treat another disorder. To overcome this challenge, a team designed a computational framework that works in two steps. First, it searches enormous patient care-related datasets with high-powered computation to arrive at repurposed drug candidates for a given disease. Second, it calculates and estimates effects of those existing medications on a defined set of clinical outcomes. As a proof-of-principle, researchers decided to focus on repurposing of drugs to prevent heart failure and strokes in patients with coronary artery disease. The edge of the machine learning approach is that it can analyze and compare thousands of human differences within a large population that could influence how a drug will work in the body. These confounding factors such as age, gender, race, and disease severity function as parameters in the deep learning computer algorithm on which the framework is based. This information is streamed from “real-world evidence,” which consists of longitudinal observational data about millions of patients captured by various sorts of electronic medical records. The team used insurance data for more than 1.2 million heart-disease patients. The algorithm analyzed each patient’s drug prescriptions and diagnostic tests for every visit and models input for drugs based on their active ingredients. The model yielded a total of 9 drugs with potential therapeutic benefits, three of which are currently in use and six new candidates for drug repurposing. Interestingly, two diabetes medications, metformin and escitalopram, have been found to lower the risk of heart failure and stroke in the model patient population. This study shows how artificial intelligence can speed up hypothesis generation and clinical trial processes. While this study focused on heart failure and stroke, the framework is flexible and could be applied to most complex diseases.

How Octopuses Are Able to Taste by Touching

Giesen et al.Molecular Basis of Chemotactile Sensation in Octopus. Cell, October 2020.

Octopuses have often captured human interest with the ability to use their eight suction-cup covered tentacles for touch and taste. Scientists have wondered for decades how their appendages work but very few have studied what happens on a molecular level. In a new report, researchers got a glimpse into how the nervous system in an octopus’ tentacles manage these functions. They identified a novel family of sensors in the first layer of cells inside the suction cups that have adapted to react and detect molecules that do not dissolve well in water. The chemotactile receptors on these sensory cells use those molecules to help the animal figure out what it is touching and whether or not that object is prey. This allows an octopus to distinguish between a rock versus a tasty crab. The underlying mechanism is that there are two types of sensory cells in the suckers that line their tentacles: mechanosensory cells for touch and chemosensory cells for taste.  Both taste- and touch-oriented cells are critical for helping octopuses to decide when to hunt and when to retreat. It is well known that particles on land easily travel through the air before they might be sniffed by a bear or a wolf’s nostrils. However, the process of smelling or tasting is much less clear in cephalopods that live in the ocean. Some chemicals can travel far from their underwater source and thus make it possible for some creatures to catch a smell of their prey from afar. But for chemicals that don’t move through the ocean easily, a touch-taste strategy can be useful for marine animals, including octopuses. While people tend to perceive five basic tastes – sweet, bitter, sour, salty and umami (meaty) – octopuses experience the world of taste differently. Instead, scientists found the most success by stimulating octopuses to respond to what are called terpenoid molecules, a secretion that is often released by marine invertebrates that functions as a defense or warning signal. They smell these molecules and can, in a way, smell fear in their prey.

Natural Forest Regrowth May Be the Best Method to Combat Climate Change

Cook-Patton et al. Mapping carbon accumulation potential from global natural forest regrowth. Nature, September 2020.

Reforestation has been considered the leading strategy in the fight to mitigate the effects of climate change with previous studies highlighting the role it can play in capturing and storing atmospheric carbon. There are many ways to incorporate trees into our landscapes, however one of the cheapest and easiest options is to allow forests to regrow on their own if conditions can permit them to. Now, a new study has mapped the potential carbon accumulation in naturally regrown forests over the next 30 years. Researchers from 18 countries brought together more than 13,000 georeferenced measurements of carbon accumulation to generate a wall-to-wall, one-kilometer-resolution map spanning 43 countries that highlights areas with the greatest carbon returns if trees were allowed to reforest naturally. The team demonstrated that natural forest regrowth can capture up to 23 percent of global carbon dioxide (CO²) emissions from the atmosphere every year. This is on top of the carbon sequestration already provided by existing forests, which absorb around 30 percent of annual CO² emissions. The biggest advantage of natural restoration of forests is that it often requires nothing more than human inaction. Nature is constantly at work doing its duty to restore forests often unseen on the edges of fields, on abandoned pastures, and wherever forests lie degraded or former forest land is abandoned. Moreover, natural forest regrowth may promote the re-establishment of local tree species that are best equipped to survive in a given location and support the many organisms that eat them or dwell amongst their branches and roots.

However, natural regrowth may not always be the answer. For example, at sites that are highly degraded, or seed sources are far away, actively planting trees can help to start or speed recovery while helping to establish the right species mix for current and future conditions. While planting trees can sometimes be necessary it should usually be the last option since it is one of the most expensive and often least successful methods of combating climate change. It is estimated that humanity should collectively plant about a trillion trees over the next three decades to effectively fight climate change, which averages out to about a thousand new trees planted in the ground every second and assumes that every tree survives and grows in a healthy manner. Once the cost of nurseries, soil preparation, seeding, and thinning are accounted for, it would easily cost hundreds of billions of dollars. If natural forest growth is cheaper and better then why not work to protect the existing trees and let forests to grow on their own?

Li et al. Innate connectivity patterns drive the development of the visual word form area. Scientific Reports, October 2020

A new study suggests that humans are born with a part of the brain that is prewired to be receptive to seeing words and letters. Researchers analyzed brain fMRI scans of 40 newborns and found that the “visual word form area” (VWFA) was already connected to the language network of the brain, which is akin to the scans of 40 adults. These findings are quite surprising considering some researchers had hypothesized that the pre-reading VWFA starts out like any other part of the visual cortex that are sensitive to seeing faces, scenes, or other objects and only becomes selective to words and letters as children learn to read or at least as they learn language. However, a new study shows that even at birth, the VWFA is more functionally connected to the language network of the brain than it is to other areas. It is likely that experience with spoken and written language will strengthen connections with specific aspects of the language circuit and further differentiate this region’s function from its neighbors as a person gains literacy. The main goal of this study is to learn how the brain becomes a “reading brain” and to help understand the differences in reading behavior, which could become useful in the study of dyslexia and other developmental disorders.

Hsueh MF et al. Analysis of “old” proteins unmasks dynamic gradient of cartilage turnover in human limbs. Science Advances, October 2019.

Humans may not be able to regrow amputated limbs, but a recent study showed that damaged cartilage may regrow through a process similar to that of animals such as salamanders and zebrafish. Scientists collected 18 specimens of joint tissue from the hips, knees, or ankles of patients who underwent surgery. They then placed the tissue in a mass spectrometer and measured the age of the cartilage proteins in the sample. These analyses showed that the age of cartilage largely depended on where it resided in the body. Cartilage in ankles is young, middle-aged in the knee, and old in the hips. This correlation between the age of human cartilage and its location in the body suggests that limb repair occurs in humans in a similar fashion to certain animals in which tissue regeneration takes place at the furthest tips such as the ends of legs or tails. This finding also helps to explain why injuries to people’s knees and, especially, hips take a long time to recover and often develop into arthritis, while ankle injuries heal quicker and less often become severely arthritic. The researchers further identified the molecules that are instrumental in the regulation of this region-specific regeneration process. They are called microRNAs and, not surprisingly, are present at very high levels in animals that are known for limb, fin, or tail repair including salamanders, zebrafish, and lizards. Scientists believe that these regulator microRNAs can be utilized in the regeneration of degenerated cartilage of an arthritic joint to reverse arthritis. Regeneration of part or all of an injured human limb may even be possible by finding components salamanders have and we don’t. Finally, it is also possible that this could be a fundamental mechanism of repair that could be applied to many tissues, not just cartilage, which might open up many new avenues in the regenerative medicine.

The universe might have many Earth-like exoplanets

Doyle AE et al. Oxygen fugacities of extrasolar rocks: Evidence for an Earth-like geochemistry of exoplanets. Science, October 2019.

New astrophysical and geochemical evidence suggests that Earth may not be that unique, and Earth-like planets may be common in the universe. All of the planets in our solar system orbit around the Sun. Planets that orbit around other stars are called exoplanets.  The first exoplanets were discovered in the early 1990s. Since then, thousands of exoplanets have been revealed with over 4,000 confirmed and a further 4,495 potential candidates. There have been major efforts to narrow down the exoplanets that may have properties similar to Earth with conditions suitable for life. This includes being a rocky planet that is not too hot or cold so that liquid water can exist. When searching for exoplanets that are similar to Earth, astronomers typically look for worlds in orbit around a type of star called a red dwarf or an M-dwarf. These types of stars are somewhat similar to our sun and make up about 70% of the stars in our galaxy. However, a new study shows that rocky exoplanets in orbit around a different type of star, a white dwarf, can have interiors that are surprisingly similar to our planet. White dwarf stars are dense remains of normal stars that have exhausted their nuclear fuel. These stars are typically composed of light elements such as hydrogen and helium, but in some cases they attract heavier elements such as magnesium, iron, and oxygen in their atmospheres due to their extreme gravity. These heavy elements are thought to be introduced when a rocky exoplanet crashes into a star, which gives astronomers evidence of what the exoplanets were like before they were destroyed. In this recent study, scientists looked at six white dwarfs located 200 to 665 light-years from Earth and rocks from the planets that once orbited it. Their analyses showed that five out of the six white dwarfs had sucked up fragments whose chemical composition is similar to rocks on Earth, Venus, and Mars. While the conditions suitable for life depend upon many additional factors, this study points towards the idea that many rocky planets are likely very familiar in terms of their general composition and, therefore, structure and behavior. This study also made a substantial leap forward in being able to make inferences for bodies outside of our own solar system and indicates that it is very likely that there are truly Earth analogs out there.

Artificial leaf points to a sustainable path to carbon-neutral fuels

Andrei V et al. Bias-free solar syngas production by integrating a molecular cobalt catalyst with perovskite–BiVO4 tandems. Nature Materials, October 2019.

An artificial leaf from which a “clean” fuel alternative to petrol could be produced has been developed. Synthetic gas can be obtained from the lead by using only sunlight, carbon dioxide, and water.

Synthetic gas, also called syngas, is typically a mixture of carbon monoxide and hydrogen. It is largely produced by exposing fossil fuels such as coal or natural gas to high temperature steam and pressure, and the process releases carbon dioxide. Syngas is broadly used in a wide range of commodities including fuels, plastics, and fertilizers. While the utilization of fossil fuels has enabled large-scale industrial development in human history, the burning of fossil fuels is the largest source of emissions of carbon dioxide, which is one of the greenhouse gases that contributes to global warming. For decades scientists have been trying to discover new ways to produce syngas in order to close the global carbon cycle and to establish a sustainable chemical and fuel industry. In a recent study, researchers got inspired by leaves. These perfect little machines use sunlight to convert carbon dioxide and water into fuel for plants through photosynthesis. An artificial leaf has been designed to have two light absorbers, similar to the molecules in plants that harvest sunlight, and a catalyst made from the naturally abundant element cobalt. When the leaf is immersed in water, one light absorber uses the catalyst to produce oxygen and the other one carries out the chemical reaction that reduces carbon dioxide and water into carbon monoxide and hydrogen, thus forming the syngas mixture. The scientists are now searching for ways to use their technology to produce a sustainable liquid syngas that could serve as an alternative to petrol. Although major efforts to generate renewable energy sources are being made, the development of synthetic petrol is critical as electricity can currently fulfill about 25% of our total global energy demand. There is a huge demand for liquid fuels to power heavy transport, shipping, and aviation sustainably.

Smart prosthetic hand combines both human and robot control

Zhuang et al. Shared human–robot proportional control of a dexterous myoelectric prosthesis. Nature Machine Intelligence, September 2019.

Holding an object in your hand might seem easy, but it’s actually a very complicated and challenging task; if, for instance, an object starts to slip, you typically have a couple of milliseconds to react. Scientists have been trying new approaches for improved control of robotic hands, particularly for use by amputees. A recent technology was able to combine individual finger control and automation for improved grasping and manipulation by successfully merging the fields of neuroengineering and robotics. This interdisciplinary approach was tested on three amputees and seven non-amputee subjects. The neuroengineers achieved the intended finger movement from muscular activity on the amputee’s stump, allowing for individual finger control of a prosthetic hand, which had never been done before. The robotics team enabled the robotic hand to take hold of objects and maintain contact with them for robust grasping. The amputee first performed a series of hand movements in order to train the algorithm through a machine learning paradigm. This taught the algorithm to decode user intention and translate it into finger movements of the prosthetic hand. Concurrently, sensors placed on the amputee’s stump detected muscular activity, which trained the algorithm to learn which hand movements corresponded to which patterns of muscular activity. Once the user’s intended finger movements were acquired, this information could then be used to control individual fingers on the prosthetic hand. When the user tried to grasp an object, the robotic automation initiated. The algorithm told the prosthetic hand to close its fingers when an object was in contact with sensors on the hand’s surface. This automatic grasping was designed to infer the shape of objects and grasp them based on tactile information alone, without any help of visual signals. The robotic hand has the ability to react within 400 milliseconds, and it is equipped with pressure sensors all along the fingers: it can react and stabilize the object before the brain can actually perceive that the object is slipping. While this promising technology can be used in in several neuro-prosthetic applications such as bionic hand prostheses and brain-to-machine interfaces, there are still many challenges remaining to implement this technology in a commercially available prosthetic hand for amputees. It is currently being tested and improved.

Cats securely bond with people, too

Vitale et al. Attachment bonds between domestic cats and humans. Current Biology, September 2019.

Dogs have long been regarded as man’s best friend. They’re sociable, faithful, and obedient. Cats, on the other hand, are often described as more aloof, mysterious, and independent. But a new study suggests that cats actually bond with their owners in similar ways to how humans and dogs bond with companions. The most established way to study human attachment behavior is to observe an infant’s response to a reunion with their caregiver following a brief absence in a novel environment. When a caregiver returns, secure infants quickly return to relaxed exploration while insecure individuals engage in excessive clinging or avoidance behavior. These tests had been previously run with humans, primates, and dogs; researchers decided to run the same test with cats. 79 kittens and 38 adult cats and their caregivers were recruited. During the test, an adult cat or kitten spent two minutes in a novel room with their caregiver followed by two minutes alone. Then, they had a two-minute reunion. The cats’ responses to seeing their owners again were classified into attachment styles. The results show that cats bond in a way that’s surprisingly similar to infants. In humans, 65% of infants are securely attached to their caregiver and domestic cats and kittens mirrored this, as about 65% of them securely bonded to their people. After the first round of tests, the researchers enrolled half the kittens used in the study in a training and socialization course. The other half served as a control group. Researchers then found the same results, suggesting the training did not have an effect on kittens’ attachment behavior toward their owners. This indicates that once a cat forms a bond, it seems to remain stable over time. This social flexibility may have helped facilitate the success of the species in human homes. It is still not clear what the factors are that shape the caretaker relationship, but it’s likely a miraculous complex mix of genetics, personality, and experience.

An efficient and green way to convert heat into electricity

Zheng et al. Paramagnon drag in high thermoelectric figure of merit Li-doped MnTe. Science Advances, September 2019.

A recent discovery could help scientists to develop more efficient ways to generate electricity from heat that would have been otherwise wasted, such as heat coming from car exhaust, industrial processes, and interplanetary space probes. In principle, magnetic fields can be used to generate electricity. If we move a magnet through a coil or wire, the magnet pushes and pulls electrons that create an electrical current. Magnets themselves don’t have energy, but they can control energy currents through the created magnetic field. The main problem with magnets is that when a magnet is heated up, it loses most of its magnetic properties and becomes a so-called paramagnet. Until this discovery, scientists believed that paramagnets couldn’t be used for generating electricity. In the new study, researchers found a way of designing thermoelectric semiconductors that can convert heat to electricity. The tiny particles in paramagnets, so called paramagnons, ended up producing enough spin to push an electron, for only a billionth of a millionth of a second – apparently long enough to make paramagnets viable energy-harvesters. This breakthrough in the conventional understanding of magnetic properties could lead to more research into how magnets and energy interact to potentially facilitate electricity production from heat that is otherwise wasted and oftentimes harmful to the environment.

Biggest extinction in Earth’s history caused by global warming—and how it could happen again

Penn JL et al. Temperature-dependent hypoxia explains biogeography and severity of end-Permian marine mass extinction. Science, December 2018.

Some 252 million years ago, long before dinosaurs, the vast majority of species on Earth were wiped out in the “Great Dying,” the worst mass extinction in our planet’s history. Up to 96% of all marine species and 70% of land animals were killed off during this event. Scientists have been trying to find the cause for this catastrophic event, which marked the end of the Permian period. One study suggested that a type of microbe spouted large amounts of methane into the atmosphere. Other studies suggested the event was triggered by a series of volcanic eruptions that released deadly amount of carbon dioxide into the air and led to cataclysmic ocean acidification. A new research study now claims that the Great Dying was primarily as a result of rapidly increasing temperatures. The researchers examined the marine fossil records and simulated the climate conditions to observe the effects of rising temperatures 252 million years ago. Researchers first ran a climate model with Earth’s configuration during the Permian period, when the tropical ocean temperatures at the surface had reached some 10 degrees Celsius (50 degrees Fahrenheit) higher. The model then reproduced dramatic changes in the oceans; oceans lost about 80 percent of their oxygen and about half the oceans’ seafloor became completely oxygen-free. To investigate the effects of these paleoclimate changes on marine species, the researchers then analyzed the varying oxygen and temperature sensitivities of 61 modern marine species including crustaceans, fish, shellfish, corals and sharks. Their calculations predicted that many marine organisms went extinct under these conditions, especially the organisms that lived far from the tropics were most sensitive to oxygen levels and they were nearly completely wiped out. To test this prediction, researchers analyzed late-Permian fossil distributions from the Paleoceanography Database and confirmed that species far from the equator suffered most during the event. The agreement between the simulations and fossils strongly suggests that climate warming and oxygen loss was a primary cause of the extinction. By 2100, warming in the upper ocean is projected to approach 20 percent of warming in the late Permian, and by the year 2300 it will reach between 35 and 50 percent. This study highlights the potential for a mass extinction arising from a similar mechanism under anthropogenic climate change. It is also a clear warning that Earth is on the path to another devastating mass extinction. According to experts, Earth could already be undergoing a sixth mass extinction that would kill off most animal and plant species. The International Union for the Conservation of Nature predicts that 99.9% of critically endangered species and 67% of endangered species will be lost within the next 100 years.

New target for therapeutic brain stimulation to treat depression found

Rao VR et al. Direct Electrical Stimulation of Lateral Orbitofrontal Cortex Acutely Improves Mood in Individuals with Symptoms of Depression. Current Biology, November 2018.

Researchers have finally found an effective target in the brain for electrical stimulation to improve mood in people suffering from depression. Stimulation of a brain region called the lateral orbitofrontal cortex (OFC) reliably produced acute improvement in mood in patients who suffered from depression. In a recent study, researchers studied 25 patients with epilepsy who had electrodes placed in the brain for medical reasons to locate the origin of their seizures. Many of those patients also suffered from depression, which is often comorbid with epilepsy. With the patients’ consent, researchers took advantage of those electrodes to deliver small electrical pulses to areas of the brain thought to be involved in regulating mood. The researchers focused their attention and the electrical stimulation on the OFC, which is a key hub for mood-related circuitry. Moreover, they specifically induced a pattern of activity in brain regions connected to OFC that was similar to patterns seen when patients naturally experienced positive mood states. The researchers applied these stimulation regimes while collecting verbal mood reports and questionnaire scores. Analyses of these reports revealed that unilateral stimulation of the lateral OFC produced acute, dose-dependent mood-state improvement in subjects with moderate-to-severe baseline depression. There is still substantial work remains to be completed before the deep brain stimulation (DBS) treatments could enter routine clinical practice. One major challenge in this study is to see whether stimulation of OFC produces durable improvement in mood over longer periods of time. Biomedical engineers hope to develop a medical device for patients with treatment-resistant mood disorders that can monitor brain activity in OFC and stimulate only when needed to keep that activity within a healthy range. Ultimately, it would be ideal if activity in mood-related brain circuits could be normalized indefinitely without patients needing to do anything.

How screen time can disrupt sleep

Mure LS et al. Sustained Melanopsin Photoresponse Is Supported by Specific Roles of β-Arrestin 1 and 2 in Deactivation and Regeneration of Photopigment. Cell Reports, 2018

For most of us, the time spent staring at screens on computers, phones and tablets adds up to many hours in a day and can often disrupt sleep. In a recent work, researchers now have pinpointed how certain cells in the eye process ambient light and reset our internal clocks, the daily cycles of physiological processes known as the circadian rhythm. When these cells are exposed to artificial light late into the night, our internal clocks can get confused, resulting in a host of health issues. A protein called melanopsin in these light-sensitive cells helps them process ambient light. Prolonged exposure to light causes melanopsin to regenerate and continuous regeneration of melanopsin triggers signals to the brain that inform it about ambient light conditions. The brain then uses this information to regulate sleep, alertness, and consciousness. In this study, the researchers turned on the production of melanopsin in retinal cells in mice and found that some of these cells are able to sustain light responses, but others lose sensitivity. Further investigations found that proteins called beta arrestin-1 and beta arrestin-2 help keep the melanopsin sensitive when exposed to light. One arrestin does its conventional job of arresting the response, and the other helps the melanopsin protein reload its retinal light-sensing co-factor. When these two steps are done in quick succession, the cell appears to respond continuously to light. This research uncovers the mechanisms behind how cells being exposed to artificial light confuses the internal body clock, and the ability to regulate sleep. It is hoped that this discovery could lead to new targets that could counter the impact of artificial light, for example by finding ways to influence melanopsin to reset the internal clock. This could lead to new treatments for insomnia, jet lag, and migraines.

Agrochemical control of plant water use via engineered abscisic acid receptors
Park et al. Nature, February 2015.

A recent breakthrough study reported that scientists successfully engineered drought-tolerant plants by adding a new piece of DNA to their genomes. Crops and many types of plants are increasingly challenged by hostile environmental conditions such as globally warming temperatures and diminishing water sources. Plants have very small openings called “stomata” that let carbon dioxide in and oxygen out. Each stoma is surrounded by two guard cells that control opening and closing using osmotic pressure. During daytime, the stomata lets plants allow carbon dioxide in and oxygen out. Since the air around the leaves is often drier than inside, water molecules also move out through the stomata – a process called transpiration. Under the stress of drought, plants produce a hormone called abscisic acid (ABA). When ABA is released, it makes guard cells close the stomata and in turn keeps the plant from losing the water. Scientists previously thought that if they could spray ABA on a whole field, plants would survive a drought. However, since ABA is very expensive and highly sensitive to light, this strategy never became an option. Then, scientists decided to take the commonly used fungicide mandipropamid and genetically engineered the plants to respond to mandipropamid as if it were ABA. By adding a new piece of DNA into genomes, plants ended up having slightly different ABA receptors, which can be efficiently activated by mandipropamid.  Researchers tried this approach on two different plants: tomatoes and Arabidopsis. When mandipropamid was sprayed, genetically engineered plants stopped transpiration, and hence were able to survive for 12 days without water. The next challenge is to test this strategy in real world crops. This approach potentially opens new avenues for crop improvement that could highly benefit a growing world population.

3D Vaccines to Cure the Cancer

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy
Kim J et al. Nature Biotechnology, December 2014.

Cancer is a devastating disease.  The World Health Organization (WHO) predicts that global cancer incidence rates will grow by nearly 60% to 22 million cases per year over the next two decades. The effective cure for cancer has not been developed yet, mostly due to its ability to escape the body’s immune system. Unlike infectious reagents like bacteria and viruses, cancer cells are actually our own cells that are broken and misplaced; they cause trouble as they grow. Scientists have been trying hard to develop vaccines that activate the immune system to recognize tumor cells as foreign and attack them. In a recent study, scientists reported that they designed a “3D vaccine” to effectively provoke the immune system to fight cancer. The 3D vaccine is composed of many microsized, porous silica rods submersed in liquid, where any combination of tumor antigens and immune-stimulating reagents can be loaded into.  Once the 3D vaccine is injected under the skin, it forms into a dime-sized scaffold that creates an “infection-mimicking microenvironment.” The scaffold then attracts the dendritic cells that patrol the body for harmful pathogens. When the scaffold was tested in mice, it showed over a 90% survival rate in animals that would normally die from lymphoma within 25 days. Further analyses in mice showed that the 3D vaccine can recruit, house, and manipulate immune cells to initiate a powerful immune response against cancer. As much as the discovery is promising, one should keep in mind that much more evidence will be required to establish 3D vaccines as a feasible way of combating human cancer.

Smoking Shrinks the Brain

Cigarette smoking and thinning of the brain’s cortex
Karama S et al. Molecular Psychiatry, February 2015.

Smoking is regarded as the single most preventable cause of disease, disability, and death. Past studies strongly linked smoking to cancer and lung diseases. A recent study now shows that smokers have a thinner brain cortex than non-smokers. The cortex is the outer brain layer in which critical cognitive functions such as memory, language, and perception take place. It is well known that the cortex becomes thinner with normal aging and cortical thinning is associated with cognitive decline and dementia. The study found that smoking accelerates this thinning process. Researchers analyzed brain MRI scans of 244 males and 260 females with an average age of 73, around half of whom were former or current smokers. Participants who had given up smoking for the longest time had a thicker cortex compared with those who had given up recently. Researchers cautiously suggest that the cortex might regain some thickness once smokers quit but the recovery is very slow and incomplete. For example, heavy smokers who had quit more than 25 years before still had a thinner cortex.

Observing Majorana fermions in the ferromagnetic atomic chains on a superconductor. Nadj-Perge et al. Science, October 2014.

In the universe, matter and antimatter particles are always produced as a pair and, if they come in contact, they destroy each other in a flash of energy. In 1937, an Italian theoretical physicist named Ettore Majorana had proposed that there can be unique exceptions to this rule: a stable particle could exist in nature that is both matter and antimatter. Scientists have been looking for that indefinable particle, also known as the “Majorana fermion,” for seventy years. A group of researchers recently reported that they were able to detect the Majorana particle which behaves simultaneously like matter and antimatter. Researchers designed an experimental system allowing them to observe an emergent particle inside a material. They first generated an extended chain of pre magnetic iron atoms on a superconductor made of lead. Then, they cooled the material to -272 C, just about one point above absolute zero, and monitored it using a giant two-story-tall scanning-tunneling microscope, which can track electrical signal changes with very high precision. Finally, they were able to capture a glowing image of an electrically neutral particle at the ends of atomically thin iron wires. The Majorana particle was surprisingly stable and the opposing properties make the particle neutral so that it interacts very weakly with its environment. The discovery of the Majorana particle has exciting implications for several areas of modern physics, engineering, and astrophysics. For example, Majorana particles are very similar to neutrinos, as they both have very weak interactions with the matter. Neutrinos are thought to make up most of the dark matter that fill the Cosmos. Perhaps, neutrinos are simply Majorana-like particles and Majorana particles are also a candidate for what dark matter is. As an industrial application, Majorana particles can be utilized in quantum computing which aims to create computers to handle incalculable systems. The current quantum computing technology uses electrons, but they are known to be very unstable due to high interaction rates with surrounding materials. However, since Majorana particles are neutral and highly stable, they can be engineered into a variety of materials to produce more reliable and powerful quantum computing applications.

The Bitter Side of Artificial Sweeteners

Artificial sweeteners induce glucose intolerance by altering the gut’s microbiota. Suez J. et al. Nature, September 2014.

There have been conflicting and confusing findings about the health effects of artificial sweeteners over the past several decades. Some studies found that they cause weight loss and others found the exact opposite. Some studies linked them to diabetes and other studies argued otherwise. A recent study provided a series of experimental evidences that artificial sweeteners disrupt the body’s ability to regulate blood sugar, and thus may cause metabolic diseases and diabetes. Researchers, using animal models and human studies, found that sweeteners significantly alter the gut’s microbiome – the collective name of bacterial colonies living in our intestines. The composition of our gut microflora plays a critical role protecting us from pathogenic bacteria, the metabolism of indigestible components of our diet, and modulating development and regulation of the immune system. Sweeteners – in the form of saccharin, sucralose, or aspartame – are found to alter the mix of microbes in our intestines and consequently change how our bodies metabolize glucose. Constant use of sweeteners in mice and human test groups caused typical glucose intolerance symptoms in which glucose levels rose higher after eating and declined more slowly than expected. Glucose intolerance can ultimately lead to serious illnesses like metabolic syndrome and Type 2 diabetes. Although this study will cause a lot of discussions and headaches in the food industry, the link identified between microbiome and glucose intolerance will definitely inspire novel therapeutic approaches to metabolic disorders such as diabetes.

Brainy Fingertips

Edge-orientation processing in first-order tactile neurons. Pruszynski JA and Johansson RS. Nature Neuroscience, August 2014

A new study found that neurons in human skin are able to perform advanced calculations that scientists thought only the brain was capable of performing. A group of sensory neurons that extend into the skin and record touch are called first-order neurons in the tactile system. Each nerve ending branches in the skin to form about 5mm2 elliptical receptive field, with up to 8 highly sensitive zones that are unevenly distributed within the field. It turns out that these neurons not only transmit information about when and how intensely an object is touched to the brain, but they also send complex information about the touched object’s shape. Researchers found that the sensitivity of individual neurons to the shape of an object depends on the layout of the neuron’s highly-sensitive zones in the skin. Computations that require untangling geometric shape information are classified as feature extraction computations in neuroscience and are typically attributed to the immensely complex circuits of the cerebral cortex. This study showed that neuronal populations localized outside of the brain, such as first-order tactile neurons, can have advanced processing capacity similar to brain neurons. These results can also potentially improve treatments for nerve injury and rehabilitation, as scientists previously assumed that the cerebral cortex was doing all the work.

These situations entail the psychology of morality-an intriguing and growing topic of study. Significant and insightful research has been completed in an attempt to understand more about morality from a psychological perspective. Many questions have been raised in the realm of morality and ethics, such as: How do people think about morality? What are people’s concepts of a moral person? How do people apply morality in conflict and their everyday lives?

In psychologists’ attempts to answer these questions, we learn more about mankind as a whole and about our own individual selves. This article will summarize some of the most prominent studies in the field of morality psychology and use these perspectives to help attain a better understanding of who a moral person is and what they do.

Exploring differences in moral foundations between political liberals and conservatives is one interesting area of research in the psychology of morality. Graham, et al. (2009) established a definition of a moral foundation as consisting of five moral intuitions: harm/care, fairness/reciprocity, in-group/loyalty, authority/respect, and purity/sanctity. The researchers found that political liberals were likely to chiefly judge a moral situation along the harm/care and fairness/reciprocity aspects, while conservatives were more likely to use all aspects equally. The results of this study seem to agree with the ideologies of liberals and conservatives. Considering that conservatives are less receptive to changes in political policies and culture, it makes sense that they would place a high value on the authority of a government, and also that they would give more weight to protecting their in-group from outside influences. This ideology may in turn stem from a Hobbesian worldview (Thomas Hobbes, 1588-1679) in that everyone is at the most basic level self-interested, and therefore they must protect their own interests from the interests of others.

Liberals, on the other hand, would be more likely to go against the authority of the government or in-group concerns if they felt a moral injustice was being committed. This may be one reason why conservatives sometimes accuse liberals of not being patriotic.

As for the purity/sanctity condition, there is some doubt as to whether it can really be considered a moral facet. Conservatives seem to think that this is the case, but liberals on the other hand give nearly zero consideration to aspects of purity during moral judgments, as it seems to be an unrelated concept. Additionally, this idea may explain why conservatives tend to be against gay marriage, while liberals are more likely to support gay relationships.

Before moving on, let me pose another question: which action is more moral, volunteering time in a soup kitchen or keeping your vow to your wife not to go to the racetrack and gamble on payday?

Now we turn our attention to an enlightening study by Janoff-Bulman, et al. (2009) that analyzed morality in a different way: by categorizing it into two distinctive types, prescriptive and proscriptive. Prescriptive morality has a commendatory and encouraging nature, and it is characterized by taking positive action and the question what one should do to be moral. Proscriptive morality is more commanding and punishing in its aspects, and it is characterized by preventing negative action and the question what one should not do to prevent immorality. The distinction between the two can be states as helping versus not harming.

The researchers provide evidence for these two different types of morality in their studies. For example, in one experiment, participants were asked to describe what they thought it meant to be-depending on the manipulation-either moral or immoral. They had correctly predicted that proscriptive morality tended to have more concrete and defined language, so as to assist its adherents in knowing exactly what actions are wrong. Prescriptive morality’s language was more abstract so as to include more possible right actions.

It was also found that people were more disapproving when someone committed forbidden acts as opposed to someone failing to perform righteous acts. This finding-that it is generally more objectionable to see an overtly immoral act than to see a failure to commit a positive act-is strong evidence for the prescriptive/proscriptive distinctions of morality.

There are many more questions about morality researchers are asking. For instance, what lies behind the rationalization of a racist behavior or attitude? How are people’s moral principles influenced by the particular identity of the individuals involved? Uhlmann, et al. (2009) examined these topics. Most of us tend to think of ourselves as having a relatively stable moral standing, but this study showed that for most people, this simply is not the case. People were presented with different moral dilemmas that measured if they would support either a consequentialist solution or a deontological solution to the dilemma. According to the researchers’ hypothesis, changing some details of the scenario could influence people’s preference for either consequentialism (the idea that it is permissible to commit an action that would normally be considered immoral for the benefit of the greater good) or deontology (the idea that there are some actions that are morally wrong under any and all circumstances); this is in fact what they observed.

They observed that political liberals were more likely to sacrifice a white man to save a black group of people and less likely to sacrifice a black man to save a white group. The reverse effect was observed for conservatives in that they were more willing to sacrifice a black man to save a white group and vice versa. They also found that conservatives were more likely to endorse the unintended killing of Iraqi civilians by American forces than the unintentional killing of American civilians by Iraqi armed forces.

These results provides a striking example of how people’s moral concepts can change when the specifics of those involved in the moral equation change, which in turn suggests that people value some lives more than others. Conservatives, in particular, seem to value people who are part of the in-group over people who are not. This study also suggests that liberals may actually devalue in-group members in an attempt to maintain a non-racist morality.

Another major question is how do religious concepts and the knowledge that one’s actions are being judged affect how people behave morally? The following study (Shariff & Norenzayan, 2007) asked participants to play a game that would measure their generosity towards total strangers. The researchers discovered that people who were primed with words relating to God and religion were more generous on average than those who received no priming. The researchers also found that priming people with secular concepts of moral institutions had the same effect.

These results provide strong evidence that people will try to act more morally if they have some idea in the back of their minds, whether conscious or not, about being judged in some manner for their moral actions. This does not have to apply exclusively to religious concepts, as the results of this study show. As a matter of fact, related research conducted by Bateson, Nettle, and Roberts (2006) showed that just the indirect suggestion of being judged by other people was enough to reproduce this effect-an increase in moral behavior. Specifically, they saw a three-fold increase in the amount paid for drinks supplied on an honor system when the image associated with payment resembled human eyes versus a control image. Apparently, a pair of eyes is enough to trigger a conscious or subconscious idea of being watched and judged.

What is known about the neural activity of the brain itself with regards to moral judgments? What roles do cognitive and emotional processes in the brain play in thinking about morality? Greene et al. (2004) conducted detailed biological mapping of brain neuronal activity of individuals during their thought processes that went along with solving hypothetical moral dilemmas. It was observed that areas in the brain associated with abstract reasoning and cognitive control-regions noted included the dorsolateral prefrontal cortex and anterior cingulate cortex-were found to be more active during very difficult moral judgments where utilitarian resolutions require violation of personal moral convictions. They concluded from their work that utilitarian moral judgments rely more on cognitive processes and abstract thinking, whilst more personal moral judgments relied primarily on social-emotional processes.

This is good evidence for two different types of moral processing-cognitive or more logical, and emotional or more personal. During this study, Greene and colleagues also considered the degree of personal relatedness of a scenario with the likelihood of utilitarian resolution, and therefore the associated cognitive processes and abstract-thinking brain regions. They looked at what happens when you alter the classic moral dilemma of the runaway trolley car (Thomson, 1986) by making it either more personal or less personal. It was observed that people were more likely to engage in utilitarian calculations when the harm was less personal-in the case, that involved pulling a lever to kill a person-as opposed to when harm was more personal, in the case requiring pushing someone off of a bridge.

Morality is often connected to religion and religious values, and a natural topic to investigate is the role that sacred values may play in moral psychology. Ginges et al. (2007) examined the Israeli-Palestine conflict in an attempt to answer the question of how sacred values are involved in the resolution of political conflicts. The researchers wanted to shed some light on several issues related to sacred values in political conflict – namely, how do instrumental incentives, such as monetary gain, affect compromise with sacred values?

Interestingly, they observed that adding instrumental incentives to hypothetical deals involving the forfeiting of some sacred value actually made the subjects who held sacred values more opposed to and outraged about compromise than if they simply offered the compromise on its own. They also found that these people were less opposed to compromise if the deal also stipulated that the opposing party would give up one of their own sacred rights.

These results are important in that they show how radically different sacred values are from instrumental values. Sacred values are, for the most part, non-negotiable, except in the cases mentioned above, and it seems as though the idea of offering something of instrumental value in an attempt to negotiate the non-negotiable only serves as an insult to those who hold these sacred values. It is only when some other sacred value is offered up that we see some willingness to compromise, suggesting that sacred values cannot be compared with instrumental values, but they can be compared to other sacred values. Because of this, one may wonder whether sacred values can really be considered truly uncontestable, as opposed to simply a different type of value that is not comparable with more material principles.

An important side of the psychology of morality concerns how people perceive the moral legitimacy of authority under different circumstances. More specifically, how much of a moral investment do the participants have in the moral issues. The researchers Skitka, et al. (2009) correlated an individual’s general degree of moral conviction with how much they either supported or agreed with the U.S. Supreme Court ruling on physician-assisted suicide in 2006 that prevented the Attorney General from prosecuting doctors in Oregon who operated under state law. It was discovered that the degree of moral investment a person had about this decision increased the variance of people’s perception of the legitimacy of authority. More specifically, people who supported the decision with high moral conviction more strongly supported the post-decision legitimacy of the Supreme Court than people with lower moral conviction, and people against the decision with high moral conviction more strongly opposed the post-decision legitimacy of the Supreme Court than people with lower moral conviction.

These results are strong evidence for the idea that our perceived legitimacy of authority is intimately tied with our moral conviction on the issues that matter most to us. In other words, if the government made a ruling that we did not agree with, but did not care much about (for example, the ruling that pizza is a vegetable), we wouldn’t have much reason to deny the legitimacy of the government. However, decisions made about issues we have a strong moral standing on tend to either strongly reinforce or strongly undermine the perceived legitimacy of authority in our attempt to reconcile our moral standing versus the decree of authority. Additionally, a study could be run to test the hypothesis that liberals would be more willing to deny the legitimacy of the government, and conservatives would be more willing to affirm the government’s power.

We believe it is moral to care about others and give charity, but what motivates the moral response of giving? Some psychologists are interested in this question. Olivola & Shafir (2011) found that people were willing to give more money to a charity if they were required to run a marathon as opposed to simply attending a picnic. This finding shows that associating donations with self-sacrifice or suffering activates people’s concepts of morality.

How could we measure if having concepts of justice and fairness cause people to strengthen their moral responses as well? An experiment might be set up in this manner: one group of participants would be told that they would be donating to a village in Africa that is suffering from a drought, and as a result, running low on food. The other group would be told that local rebels are constantly raiding the village and taking their food, thus depleting their food supplies. We would then measure how much people would be willing to donate to the village in each situation. The condition of need arising from a natural disaster should not activate concepts of justice and fairness; however, even if some people think suffering from droughts is an inherently unjust event, the second condition – need arising from a military-type attack – should greatly outweigh the first in terms of justice/fairness considerations. Based on the results of the Olivola & Shafir (2011) study, it is reasonable to expect that people would donate more money to the people being raided, since that condition should activate moral concepts such as justice and fairness.

What do these studies tell us about what a truly moral person is? Let’s first look at the five moral foundations again, from Graham, et al. (2009). It appears that a truly moral person bases their judgments primarily on harm/care and fairness/reciprocity. This is because there can be situations where authority or in-group concerns can conflict with harm and fairness considerations, and in these situations the latter set of moral outlooks should prevail. One only needs to consider an example such as this: imagine you are asked to commit atrocities in the name of your country. It should be clear that these atrocities couldn’t be justified in this way. Based on the results of Skitka et al. (2009) such a request may even lead one to deny the legitimacy of whatever authority commanded this action-which is what a truly moral person would and should do in that situation. For reasons like these, harm/care and fairness/reciprocity should be on the forefront of one’s moral concerns.

Harm/care and fairness/reciprocity are also probably closely related to each other, and in many situations, one moral concept is found with the other. Consider an instance where a person beats his wife in an act of drunken violence. It’s clear that harm/care are involved in this situation, but also consider that we could say that what he is doing is an injustice to his wife. Similarly, suppose an example where a banker swindles a client for thousands of dollars. It’s clear this has to do with fairness/reciprocity, but we could also consider this action as a way of harming somebody else in a non-physical manner.

Research further clarifies a truly moral person as one who leads a disciplined life that builds off of the proscriptive, preventing immorality, and subsequently the prescriptive, acting morally. Such a person must be a role model for everyone else to follow. For this reason, a truly moral person is careful not to commit proscribed acts. A person who performs many good deeds, but also many bad deeds, will appear insincere and hypocritical. In other words, a truly moral person does their best to not mix the good with the bad. Once a person has built a strong moral foundation of avoiding proscribed behaviors, he or she can branch out and help others with ever-increasing frequency. Furthermore, with regards to the study on the effects of being watched, a truly moral person acts in every situation as though he or she is being watched or will be judged later on, even if they know that they are alone. This is because they know that any action they do may have consequences at some point, either immediate or distant.

Work in the area of the psychology of morality sheds some light on how a moral person behaves, however an ideally moral person does what is right with 100% accuracy, and no matter what the circumstances. This is an ideal, and very few people can be considered to be ideal moral examples. Prophets are the only people who could be considered to be morally infallible. Prophets like Moses, Jesus, and Muhammad, peace be upon them, serve as examples of perfect moral conduct. Even though none of us can hope to attain the rank of a Prophet, every person ought to strive for this ideal and be the best person they can be. If we hope to have any positive impact on the world we must first start by changing ourselves for the better. Only then can we attempt to sincerely help other people around us, starting with our close family and friends, and later on, the larger world.

M. Tarik Ozgur is a graduate of Lehigh University Physiology Department in 2013.

References

• Bateson, M., Nettle, D., & Roberts, G. (2006). Cues of being watched enhance cooperation in a real-world setting. Biology letters, 2(3), 412-414.
• Ginges, J., Atran, S., Medin, D., & Shikaki, K. (2007). Sacred bounds on rational resolution of violent political conflict. Proceedings of the National Academy of Sciences, 104(18), 7357-7360.
• Graham, J., Haidt, J., & Nosek, B.A. Liberals and Conservatives. Journal of Personality and Social Psychology. 96 (5), 1029.
• Greene, J. D., Nystrom, L. E., Engell, A. D., Darley, J. M., & Cohen, J. D. (2004). The neural bases of cognitive conflict and control in moral judgment. Neuron, 44(2), 389-400.
• Janoff-Bulman, R., Sheikh, S., & Hepp, S. (2009). Proscriptive versus prescriptive morality: Two faces of moral regulation. Journal of Personality and Social Psychology, 96(3), 521-537.
• Olivola, C. Y. (2011). When noble means hinder noble ends: The benefits and costs of a preference for martyrdom in altruism. The Science of Giving: Experimental Approaches to Study of Charity, 49-62. New York, NY: Routledge.
• Shariff, A. F., & Norenzayan, A. (2007). God Is Watching You Priming God Concepts Increases Prosocial Behavior in an Anonymous Economic Game. Psychological Science, 18(9), 803-809.
• Skitka, L. J., Aramovich, N. P., Lytle, B. L., & Sargis, E. G. (2009). Knitting together an elephant: An integrative approach to understanding the psychology of justice reasoning. In The psychology of justice and legitimacy: The Ontario symposium (Vol. 11, pp. 1-26).
• Thomson, J.J. (1986). Rights, Restitution, and Risk Essays, in Moral Theory. Cambridge, MA: Harvard University Press.
• Uhlmann, E. L., Pizarro, D. A., Tannenbaum, D., & Ditto, P. H. (2009). The motivated use of moral principles. Judgment and Decision Making, 4(6), 476-491.

Elephants can determine ethnicity, gender, and age from acoustic cues in human voices. McComb et al. February 2014, PNAS.

African elephants (Loxodonta africana) are the largest land animals on Earth and they have been facing the danger of extinction due to habitat loss and illegal hunting for their ivory tusks. Elephants are also known to be very intelligent creatures and a recent study showed that they can even differentiate between human languages. Researchers at Amboseli National Park in Kenya played two different recordings of human voices for elephants. One group of voices belonged to local Maasai men, who happen to have violent encounters with elephants from time to time while herding their cattle. Other voices belonged to Kamba men, who are farmers or employees of the national park, and usually pose no threat to the elephants. In both cases, researchers played the same phrase, “Look, look over there, a group of elephants is coming,” in two different languages. When elephants heard Maasi voices, they demonstrated defensive behaviors, such as gathering together, investigative smelling through their trunks, and moving cautiously away from the stimuli. Interestingly, elephants showed a greater reaction to the voices of Maasi men than Maasi women or boys, suggesting that they can even differentiate the gender and age of humans. In contrast, when they heard Kamba voices, of any gender or age, they did not show any concern. Ability to recognize predators is a crucial skill for many animals, and elephants seem to be capable of pinpointing the ethnicity, gender, and age of a potential predator, perhaps through recognizing acoustic cues in human voices. This ability serves as an early warning system for elephants and it could become very useful, especially when the predator is out of sight.

Set your alarm early to control weight

Timing and intensity of light correlate with body weight in adults. Reid JK et al. February 2014, PLOS ONE

Early sunlight exposure in the morning has been found to lower a person’s body mass index (BMI). A recent study showed that 20-30 minutes of morning light controls approximately 20% of the variation in a person’s BMI. This effect was independent of physical activity, caloric intake, sleep timing, age, or season. Our bodies have an internal body clock called the “circadian clock.” It roughly controls 24-hour cycles of physical, mental, and behavioral activities. Light is the most potent regulator of our circadian clock. It sends strong signals to our brain and body, which in turn regulate our energy balance and metabolism. Previous studies showed that animals with an altered circadian clock gain weight even though they don’t eat more. Similarly, new research with study subjects showed that missing out on the early rays of sun shifts our circadian clock and alters our appetite, satiety, and even the way that our body processes food, which ultimately leads to weight gain. In modern times, we live and work indoors, thus are often not able to get enough light in the morning. While the daylight is the best source, experts think that standing by the windows or even using a strong desk lamp would be sufficient to properly synchronize our circadian clock in the morning.

Mystery of zebra stripes solved

The function of zebra stripes. Caro T. et al. March 2014, Nature Communications

The black and white stripes of zebras have intrigued people for centuries. Scientists have speculated many hypotheses for the purpose of these stripes, such as camouflage, heat management, social implications, etc. A new systematic study analyzed 7 different equid species with stripes on their bodies and mapped their geographic locations. Then, researchers generated a statistical model by comparing the stripe patterns of these animals and their environmental conditions. Strikingly, they discovered a clear overlap between the range of striped animals and where biting flies, like horseflies or tsetse flies, are highly populated. Scientists noticed greater striping among animals in regions where there were more flies. These results suggest that having stripes may protect zebras from biting flies. Zebras, unlike other African hooved mammals living in the same area, are particularly susceptible to biting, as their hair is shorter than the pinchers of the biting flies. A separate work has shown that some flies tend to avoid black-and-white striped surfaces, supporting the hypothesis that biting flies may avoid the striped surfaces of zebras. As much as these results are encouraging, no one actually observed zebras in the wild to see if biting flies avoid landing on them, in part because it’s almost impossible to stay that close to zebras. The next challenge for the researchers is to observe this phenomena live in the wild.

You know education is always a hot topic. Everybody has a share and interest in education: Parents, educators, government officials, elected public representatives, nonprofit organizations, religious groups, and so on. Besides, there are many aspects of education, such as finance, law, administration, etc. However, do you also think that teachers have long been overlooked regarding their authority in their own classes? Haven’t they been overlooked regarding their professional development, even though they are the backbone of the education system and they need some assistance in their efforts more than ever? It is good if you also think like me. It is even better if you don’t. Thus, you can share your recommendations with me once you see this school where things are done differently than many other contemporary schools. These teachers at this school see themselves as a learning society. They criticized the status quo they were in some time ago, and renewed themselves collectively. I want you to see the product. Let’s start our journey, shall we?

Room 114

We enter through the big doors of the school. Physically, it is not the best school you would ever see, but it can definitely be said that vitality and cleanliness of the halls stand out. The atmosphere is very welcoming; something is different, but it is hard to tell what it is. I point to the very first door on the right hand side. With pride, I ask if you would like to see this classroom. The sound coming from room 114 is not different from the sound that bees make when they work. As we approach the door, I understand that this is Ms. Williams and her eighth-grade students studying math. She welcomes us and tells us, “please come on in; there are some empty chairs over there,” pointing to two empty chairs, and we make our way towards to the back of the class and have our seats. This is a math class, but I don’t see any numbers on the board or equations being discussed. Soon, we understand that they finished the chapter on expressing roots of cubic equations last week, and today they are discussing a person named Omar Khayyam (1044 – 1123 C.E.). Ms. Williams knew that Omar Khayyam was a philosopher, mathematician, astronomer, and poet. She had formed her students into four groups, and assigned each of his professions to a group, so that they could do some research and present their findings to the whole class. I understand what you mean from the way you look at me: you’re sure this is a math class? you seem to be saying. You’re right to ask. Don’t they need to finish a chapter and pass to the next one immediately, and stay focused on the possible topics that are asked at the end-of-year tests?

Let’s hold on to that question; we can ask this after the class is dismissed. The first three groups already talked about his contributions to philosophy, astronomy, and poetry. We feel very fortunate not to miss at least the last group, who talk about him as a mathematician. I can see brightness in students’ eyes, and their excitement to share everything they have learned with their classmates. The first student, Omar who coincidentally happens to share a name with Omar Khayyam, begins. Omar Khayyam was a scholar among many others of his time. He is best known today for his poetry, but his contribution to mathematics was great. He showed how to express roots of cubic equations by line segments obtained by intersecting conic sections… Another student, Margaret continues: his work on algebra was known throughout Europe in the Middle Ages, and he also contributed to calendar reform. The algebra (from Arabic al-jabr) of Khayyam is geometrical, solving linear and quadratic equations by methods appearing in Euclid’s Elements… April inserts that Khayyam also gave important results on ratios giving a new definition and extending Euclid’s work to include the multiplication of ratios.

They continue their discussion, asking how these scholars tried to seek knowledge and an answer to who they were; and the great contributions they made towards peace and understanding among people of different origins. However, I am currently very much impressed and I lose myself in the beauty of these students’ discussion that I have found myself holding my breath and forgot about your presence next to me. It was no different than waking up from a dream when the bell was ringing. Sure, I will introduce you to Ms. Williams. I understand that you want to learn more about the uncommon method she adopted for this class: Ms. Williams, do you have a minute, please?

Of course, she says: “I have some time. It’s break time now.” You ask her about the topic and the way she formed her teaching method: Why would you choose a person from old history to discuss? Why do you want your students to talk about poetry or astronomy or philosophy in a math class? Do you think they know enough math to solve the questions on the end-of-year test? Why did you choose a Muslim scholar? Is this an Islamic or a secular school? Would you… and you realize you have bombarded her with your questions. You halt and smile.

She smiles back and says: “Yes, this is a secular state school. We try to practice secularism in a true sense that we can talk about religion, and bring religious materials to school to study, but we never try to impose these ideas into our students’ minds. They actually study very different kinds of perspectives, and they enjoy it very much. We take each student as a whole. Since our topic was roots of cubic equations, and Omer Khayyam was the father of the idea, you happened to see this example.”

“But why would you touch on different areas of study in a math class?” You say without taking a second breath.

Ms. Williams smiles again. “This is very common in our school. I am sure Mr. Wraga next door will also get into some math in his literature class since he knows my course syllabus. We try to keep our teachings interdisciplinary as much as possible. I receive feedback that kids enjoy it greatly. I understand your concern about the tests. However, testing is the very last thing we think of. Most of our students do well at those tests anyway, and those who cannot do so well are seen to be still successful mostly as artists or musicians…”

There is a long pause and silence now, but hurricanes are happening in our minds. How is it possible? What kind of philosophy is this school following? Is it the principal who leads these teachers like a conductor leading an orchestra? As Ms. Williams answered our questions, more questions kept popping up in our minds. The bell rings again, and the break is over. We thank her for letting us sit in the class. We make our way back to the hall again, and I am already elated with the intelligence of these students. You look at my eyes without saying a word, and smile: Room 115?