Enveloping our body like a piece of clothing, our skin is a miraculous organ that both forms a barrier against potential invaders and plays a crucial role in the maintenance of vital functions. It is a mirror that reflects our experiences, memories, and fate with the lines and marks on it. With a surface area of 1.72 square meters and a weight of approximately 9.6 kg, including the fatty tissue under it, the skin is the largest organ in our body and life cannot possibly be maintained without it.[1] It is through the skin that we learn knives cut, fire burns, and our mother has very soft hands. We don’t even realize, but the skin quietly carries out other numerous functions such as sweating toxins out of the body, maintaining body temperature, and synthesizing vitamin D.[2] Some of these functions are related to the sun and the protection of our body from it.

The sun emits all kinds of rays across the electromagnetic spectrum. The lethal ones among these rays are filtered by the atmosphere that envelops the Earth, so very few of these dangerous rays reach the land.[3] The rays that reach Earth are visible (wavelengths of 400-700 nm) and ultraviolet (wavelengths of 100-400 nm) rays. Ultraviolet radiation comes in three types: UVA, UVB, and UVC.

Having wavelengths of 320-400 nm, UVA rays make up 90% of the UV that reaches Earth’s surface. Regardless of whether it is cloudy or sunny, the same amount of these rays reaches Earth and penetrates as far as the lower layers of the human skin. UVA rays damage the connective tissue under the skin, causing the skin to get old and the formation of free radicals, which indirectly cause DNA damage, hence terminal skin cancers or melanoma. Rays that come in these wavelengths are also largely responsible for allergic reactions on the skin.

With wavelengths of 280-320 nm, UVB rays make up 5-10% of the UV radiation reaching Earth. These rays help with the synthesis of vitamin D but also cause sunburns and the synthesis of melanin in the skin. UVB rays also have a role in mutating genes that prevent growth of tumors, thus leading to the development of skin cancers other than melanoma.

With wavelengths of 100-280 nm, UVC rays are harmful to living things. When they reach the Earth’s atmosphere, UVC rays interact with the oxygen atoms here. This interaction leads to the formation of the ozone layer, which prevents UVC rays from almost never reaching the ground. These dangerous waves have been put into humankind’s service by being employed in the creation of the protective ozone layer.

Ultraviolet rays and the harmful effects of visible light on the skin

There are short-term and long-term effects of UV rays on the skin.

The short-term effects are sunburn, heat stroke, allergic reactions, suntan, and viral diseases such as herpes, which are usually felt shortly after exposure to the sun and can be triggered by suppression of the immune system. The long-term, accumulative effects are photo-aging (the skin getting wrinkly due to solar rays), sunspots, cataracts, and the development of skin cancers.[4]

On the other hand, our skin is not entirely unprotected against the dangerous effects of the sun. The keratin layer in the epidermis, the uppermost layer of the skin, absorbs or disperses light, so the amount of light penetrating into the layers below is significantly lowered. Beta-carotene in the skin along with some enzyme systems reduce free oxygen radicals released after exposure to the sun and thus eliminate solar damage. Likewise, melanin, which gives our skin its color, lies above the nuclei in skin cells and acts as an umbrella that protects the cellular DNA from solar radiation.[5]

Six subgroups of skin types have been determined according to color of the hair, eyes, and skin, as well as the skin’s reaction to solar rays. This classification is widely accepted for identifying risk groups and determining specific protection measures.[6]

Although the number of melanosomes, or melanin-producing cells in the human skin, is the same in all humans, the color of the skin is determined by the genetic differences in the type, amount, and size of melanin pigments. Melonosomes in Europeans are small and light, while those of Africans are larger and darker.[7]

The importance of protection from the sun

The frequency of skin cancer has been increasing, which is precipitated by the fact that the ozone layer has gotten thinner and people are not well informed about UV protection. Many people take beach vacations and sunbathe, do mountain sports, have tanned skin, work in open air professions (such as construction workers, lifeguards, and tour guides), and they do so without much care.

For protection, we should first know that harmful effects of solar rays accumulate over time. The damage caused by the sun is stored in the body, just like change we save in a piggy bank. Unfortunately, we accumulate 40-50% of the total damage we are exposed to in a lifetime in the first quarter of life – that is, during childhood and our teenage years.[8] The skin’s natural protection mechanisms are not fully developed during these periods, nor is our understanding of protection. A research study carried out in Australia has shown that the rate of malign melanoma seen in young people can be reduced by 73% through effective solar protection methods.[9]

The major reason for wrinkles, the primary and fundamental indication of aging skin, is not in fact our age but the sun. UVA and UVB rays break down the connective tissue below the skin, disrupt the skin’s repair mechanisms, and cause skin aging (or photo-aging). Therefore, photo-aging takes place faster and earlier in people who work outside.[10]

{Picture: Photo-aging visible on one side of a truck driver’s face}[11] 

It’s imperative that we begin teaching children and adolescents about UV protection: having suffered five sunburns in childhood and early youth increases the risk of developing melanoma by 80%.[12] Children shouldn’t spend long hours in the midday, summer sun. 

Solar damage isn’t just more likely in children and teenagers, but also in people with skin type 1 or 2 (light skin), red hair, and/or colored eyes (blue); people, especially light-skinned people, with many skin moles; people whose family members have or had skin cancer; those who have a skin disorder triggered by the sun (lupus, dermatomyositis, rosacea); and people who have innate light sensitivity (albino, xeroderma pigmentosum, etc.). All these groups must be particularly careful about protecting themselves from the sun.

What are some ways to protect ourselves from UV Rays? Well, because UV radiation bombards the Earth most intensely at noon during the summer, staying indoors is greatly recommended between the hours of 10:00 am and 4:00 pm.  Additionally, the reflection rate of solar rays is higher by the seaside and in snowy environments.[13]

Wearing appropriate clothes is still the most effective and the least expensive method of sun protection. Clothing can have a solar protection factor (SPF) of 15-30. The level of protection is determined by the type of fabric, number of pores, and type, color, and thickness of weaving. The best clothes are made from cotton, silk, and denim and are unbleached and woven tightly. Wet clothes are more permeable. The use of wide hats, sunglasses, and umbrellas are also important for protection.

In addition to these measures, sun protection creams should also be used. The idea that protection creams will prevent the synthesis of vitamin D, voiced frequently lately, should not prevent the use of sun protection because the solar rays we receive during the day from the face and hands are sufficient for the synthesis of vitamin D. A person should pick a sun cream appropriate for their skin and apply it in sufficient amounts 20 minutes before going out. Babies should be protected through natural means, and physical sun protection should be used for children and pregnant women. A person should reapply sun protection products every two or three hours while outside, and, if planning to swim, they should choose water resistant products.

Besides physical protection that blocks, scatters, or reflects solar rays, there are also skin-absorbable chemical protections with cosmetically accepted formulations that eliminate light by absorbing it.

Generally speaking, a good sun protection should protect against both UVA and UVB rays. It should be cosmetically acceptable, non-toxic, water and perspiration resistant, and at the appropriate SPF (sun protection factor) level. However, because reapplication is required every two to three hours, protection above SPF 50 is the same. Therefore, it is no use buying a more expensive, higher protection product.[14] For people with type 3 skin (darker white skin with gold tone), SPF 30 is sufficient. For light skinned people, children, and pregnant women, however, SPF 50 is recommended.

SPF is the number indicating by how many more times a sunscreen protects the skin against UVB than the skin itself. Skin type is very important in sunscreen choice. The natural protection period of a person with type 1 skin is 5-10 minutes, while it may go up to 90 minutes for a person with type 6 skin. In other words, a light-skinned person gets a sunburn in 5-10 minutes of exposure, while a dark-skinned person may not get one at all. Therefore, these people should not choose products at the same SPF level. For example, if the skin’s self-protection duration is five minutes, a sunscreen with a SPF of 30 provides the same protection for 150 minutes.

Apart from sun protection creams, oral products can also help with sun protection. For example, oral zinc intake is proven to prevent cellular and DNA damage caused by UV radiation. Vitamin C is effective at preventing UVA rays due to its antioxidant properties and vitamin E at preventing UVB rays. In addition, the intake of beta carotene (a precursor of vitamin A) and bioflavonoids (also called vitamin P which generally has effects similar to vitamin C), found in orange and red fruit, protects against UV damage. Polyphenolic compounds in green tea also display protective properties against UV radiation.[15]

Finally, we should remember that using a sun protection product is a small part of our attitude toward your overall protection from the sun. Considering the role of the ozone layer in filtering the sun’s harmful rays, we should protect the perfect balance in the universe and re-evaluate our responsibilities and future actions for the maintenance of this balance.

Notes

[1] livescience.com.

[2] Gilchrest BA. “Sun exposure and vitamin D sufficiency,” Am. J Clin Nutr. August 2008, Vol. 88 # 2 570S-577S.

[3] Understanding UVA and UVB. skincancer.org.

[4] sciencelearn.org.nz.

[5] “The Protective Role of Melanin against UV Damage in Human Skin.” Photochem Photobiol. 2008; 84(3):539-549.

[6] laserdocs.co.uk/easy-way-to-find-out-your-fitzpatrick-skin-type/

[7] Ibid.

[8] Adele CG, Sarah C Wallingford and Penelope M. “Childhood exposure to UV radiation and harmful skin effects: Epidemiological evidence.” Prog Biophys Mol Biol. December 2011, 107(3): 349-355.

[9] Green AC, Williams GC, Logan V, Srutton GM. “Reduced Melanoma after Regular Sunscreen Use: Randomized Trial Follow-Up,” Journal of Clinically Oncology. 20 January 2011, Vol. 29 # 3:257-263.

[10] Fitzpatrick’s Dermatology in General Medicine.

[11] www.nejm.org/doi/full/10.1056/NEJMicm1104059.

[12] Markovic SN, Erickson LA, Rao RD, et al. “Malignant Melanoma in the 21^st Century, part 1: Epidemiology, risk factors screening, prevention and diagnosis.” Mayo Clin Proc, 2007; 82: 364-380.

[13] Skin cancer prevention and early detection. www.skincancer.org.

[14] www.dermnetz.org.

[15] Halliwell B. “Free radicals, antioxidants and human disease.” Lancet 1994; 344-:721-724.

The eye is a miracle as it is. Even though we have a rough understanding of its basic anatomy, we are confronted with a much more complex miracle when we venture into the intricacies of its anatomy and the physiology of the act of seeing. We have theories about the many details – such as the perception and representation of mental images and their storage in the memory – but we still do not exactly know how the act of seeing works.

One of the most mysterious layers of the eye, the retina has an elaborate structure with a slew of functions. Not every eye surgeon dares touch the retina, which houses the most sensitive and special cellular layers. It is a three dimensional, crescent-shaped structure located in the back of the eye and is made up of ten super thin layers of cells that span the exterior part of the eye abutting the veins and its interiors.

Retinal layers

The ten layers that form the retina are:

1. Pigment (coloring matter) layer
2. Layer of rods and cones
3. External limiting membrane
4. Outer nuclear layer comprising rod and cone cells
5. Outer plexiform layer
6. Inner nuclear layer
7. Inner plexiform layer
8. Ganglion layer
9. Nerve fiber layer
10. Inner limiting membrane

These layers are incredibly sensitive and elaborate, and studying their intricate structure give a sense of awe.

Light for sight

Light first arrives at and penetrates through the cornea, the living glassy layer at the outermost layer of the eye. It then goes through the frontal fluid (aquesous humor) and the aperture called the pupil (pupilla). It hits the internal wall of the retina (the inside of the crescent) after passing through the lens in the eye and then the optic fluid filling up the chamber in the back. This alone is an interesting fact because it is much later that the light that gets to the retina reaches the layer of sensitive cone and rod cells, which perceive light. As these cone and rod cells are lined one after another for their protection, light reaches this outer layer of the retina after the ganglion cells, retinal layers and nuclear layers. Such an alignment leads to a reduction of acuity in the peripheral regions of the retina.

We have theories about the many details – such as the perception and representation of mental images and their storage in the memory – but we still do not exactly know how the act of seeing works

The central pit (fovea centralis)

The inner layers at the center of the retina, on the other hand, are drawn to the sides to prevent any loss in visual acuity. Resembling a pit, this section is much thinner than the periphery of the retina, so the layers that are likely to obstruct the passage of the light, and hence reduce visual acuity, are aligned specifically to allow light to directly hit cone and rod cells. Besides, cone cells, which are in charge of exact, colored sight, exist in this region, whereas rod cells, which are in charge of rough and uncolored (black and white) sight, do not.  The central pit where visual acuity is at its highest is for keen, colored, and exact sight. Why then is the rest of the retina not created for acute sight and why is this small section equipped with this ability?

As it turns out, if the entire retina had the ability to see keenly then it would not be possible for the eye to focus on a spot and accurately distinguish it from surrounding objects. If we could see the entire page of a book at a glance, for example, the lines would mix up in our brain. We would not be able to understand what we are reading. We normally start reading from the top of the written page and continue line by line as we focus on and take in each word. Our brain then can focus and perceive a single word accurately by restricting keen perception of the surrounding area.

The retinal pigment layer

The color black is known to absorb, not reflect, light. Thanks to such absorption, the layer made up of black pigments (melanin) or dyes prevents the reflection of light, which is crucial for visual acuity. This black substance functions like the black dye in the bellows of old cameras. If there were not any layer to absorb light, light would scatter off the wall inside the eyeball, thereby obscuring the sharpness between light and dark spots, which is essential for the formation of a clear image, and producing a blurry image due to the overall illumination of the retina.

People who lack this melanin pigment as a result of a genetic defect (Albinism disorder) have white hair, and they are oversensitive to light because the colored iris layer of the eye does not contain the melanin pigment, which refracts light. When an albino person enters a bright area, the light that hits the retina is reflected in all directions through the pigment-lacking retina and the white surfaces of the rigid layer underneath (sclera). Therefore, a ray of light that would normally stimulate a few cones or rods is scattered everywhere, stimulating all or most of the light receivers. As a result, visual acuity in albinos can only be between 20/100 and 20/200, even with the help of the best optical correction, which is a low value compared to 20/20 in normal sight. The joke that rabbits do not wear glasses because they eat carrots is based on the high concentration of vitamin A in this pigment, or black dye, layer of the eye. Indeed, vitamin A is a crucial factor for the health of these pigments.

Layer of rods and cones

Composed of 127 million light-sensitive receivers (photoreceptors), the retina is 0.2 mm thick at the yellow spot (macula lutea), where the image forms most clearly, and 0.1 mm thick at the edges of this area. The 120 million cylindrical rods in the retina are in charge of black and white sight (at twilight), and the 7 million tapered cones, of colored, colored and exact sight. The more common cylindrical rods are 50 µm (microns) in length and 1-5 µm in thickness. The less common cones are 40 µm (microns) in length and 3-5 µm in thickness.

The concentration of the cones increases toward the center of the retina and decreases toward the edges, to be outnumbered by the rods. In the cytoplasm of the cones and rods are stored substances that are sensitive to light (photosensitive) which break up when light contacts them and produce electricity in the cones and rods. In rods this chemical is called rhodopsin. In cones, on the other hand, are three substances corresponding to the colors red, green, and blue that are sensitive to the wavelengths of colored light. To be more exact, there are three separate cone cells that include one of these three substances. Chemically, the photosensitive substances in the cones are a little different from rhodopsins.

The destruction of rhodopsin by light energy

Rhodopsin, along with the color substances, fills up about 40% of rods and cones. They are made up of a protein called scotopsin and a molecule called retinene that is derived from vitamin A. When light energy is absorbed by rhodopsin or the color substances, rhodopsin starts to fade in as fast as one trillionth of a second. The underlying reason for this is that the electrons in the retinene (vitamin A) part of rhodopsin is activated by light, which alters the shape of the retinal molecule at a mind-boggling speed (one trillionth of a second). Extremely complicated and precise chemical and physical changes then take place. It is very difficult to monitor all of these biochemical changes, and they require specialization [1].

The regeneration of the rhodopsin destroyed by light

Rhodopsin destroyed by light is regenerated in the dark. Only in the twentieth century did we manage to partially identify the mechanism by which molecules with very specific geometric shapes decay at incredible speeds only to be regenerated later. It is wondrous that such knowledge and power are present in the cell allowing the light energy to destroy the molecule and the regeneration process is launched. The circulation between destruction and regeneration of the molecule continues throughout a lifetime [2]. Vitamin A is assigned a crucial task in the generation of rhodopsin in the dark. All-trans retinal is converted in the retina into all-trans retinol, which is then converted into 11-cys retinol with the help of an isomerase enzyme. Finally, 11-cys retinol is converted into 11-cys retinal, which in turn combines with scotopsin to form rhodopsin. Vitamin A is present both in the cytoplasm of rods and in the pigment layer of the retina. In this way, vitamin A is kept in reserve to be used for generations of new retinal. If, on the other hand, there is an excess of vitamin A in the retina, the excess amount is converted into retinal, by which the amount of light-sensitive pigment in the retina is lowered.

Night blindness

Night blindness appears in anyone who suffers a serious deficiency of vitamin A. Because there is a lack of vitamin A to be converted into retinal, rhodopsin amounts decrease dramatically. This disease is called night blindness as it is noticeable only in the dark or at night and does not affect sight during the day, due to the reduction of light for proper seeing. In daylight, however, cones can still be stimulated despite a similar decrease in color pigments. Night blindness typically only appears in people that have a low vitamin A diet because huge reserves of vitamin A are normally stored in the liver to be used for the eyes.

The human retina contains 400,000 light receptive cells per square millimeter. For comparison, this number is 680,000 in the retina of the owl, which needs to perceive even the slightest glow when hunting in the night. As another example, with 397,000 such cells the amount in the cat’s retina is almost the same as ours.

An average of 130 sight cells in the retina are connected to a ganglion (nerve node) cell. Constituting the nerve of sight, or the optic nerve (nervus opticus), every nerve fiber is connected to a ganglion cell. It takes about 15-60 seconds for the retinal optic nerves to adapt from dark to light, while it takes as long as 30-45 minutes to adapt from light to dark. The visual range of optic cells, i.e. the lowest and highest amount of light the eye can perceive, is between 10^-7 and 10⁶ nanometers. Light that is below or above this range is invisible to us because of its insufficient or overwhelming wavelength.

All the colors we see in the world are named according to the wavelengths absorbed and reflected by optic cells. The spectrum of the optic cells lies between red and violet, which is the limit of visible light for humans. Light with a wavelength of 400 nm is perceived as violet, while light with a wavelength of 760 nm is perceived as red. Our eyes cannot see infrared and ultraviolet light. Some animals, however, are known to see light beyond these limits. For example, we know that bees can see certain shades of ultraviolet light, which helps them find flowers to pollenate.

Clearly, it is not an easy job to elaborate on the divine art manifested in such a small area as the retina. Complicated structures and reactions that require specialization even to comprehend keep taking place smoothly every moment we look around. At least we can be thankful for this amazing gift of vision given to us free of charge so that we can recognize the universe.

Notes

[1] It causes the cys form of the molecule to change into the all-trans form. Although the all-trans form has the same chemical structure as the cys form, its chemical structure is different in that it is a flat rather than angular molecule. With the impact of light photons, the position of the molecule in space changes, yet its chemical composition remains the same. Because the position of the reactive regions of all-trans retinal no longer fit in with the reactive regions on scotopsin protein, the molecule is pulled off. The product that forms at that moment is batorhodopsins, which is a partly destroyed combination of all-trans retinal and scotopsin. An extremely unstable compound, batorhodopsin turns into lumirhodopsin in nanoseconds, into metarhodopsin I in microseconds, into metarhodopsin II in about one millisecond, and finally into decomposed products, scotopsin and all-trans retinal much more slowly (in seconds).

[2] The first step in the reformation of rhodopsin is the recycling of all-trans retinal into 11-cys retinal, which requires ATP energy and is catalyzed by retinal isomerase enzyme. Once created, 11-cys retinal combines with scotopsin to form rhodopsin.

The hectic life style that many of us lead today causes stress which is likely to result in diseases of the heart or nervous system. The fast food culture has become a part of our lives due to our busy work schedules; this sort of a diet obviously causes an excess intake of fat. Office hours spent sitting on a chair without effective physical activity result in the storage of unused energy in the body. Thus, cardiovascular diseases have become one of the most common life-threatening risks for people living in developed countries. In the last five decades, much research has been devoted to investigating and preventing the risk factors that lead to coronary artery diseases.

The mushroom is a food with a rich nutritious content. Some species are known for having characteristics that are helpful in regulating the immunity system, preventing tumor formation, and reducing blood pressure without producing any known side effects. 88–91% of the physical make-up of a mushroom is water, thus fresh mushrooms are rich in proteins which can be more easily digested than many other vegetables. In addition to such proteins that are necessary for general health, mushrooms consist of B-complex vitamins and mineral materials.

Some species of mushrooms act as sources of healing in many ways. Polysaccharide-protein complexes obtained from species like Pleurotus spp., Ganoderma lucidum (Reishi), Grifola frondosa (Maitake), Lentinula edodes (Shiitake) have been found to prevent the spread of tumor cells and AIDS. It has also been discovered after research that mushrooms have antiviral, antibacterial, and antifungal effects; they are useful in the treatment of illnesses like cold, stomach and head aches, and hepatitis B; they can help reduce fatigue and sleeping problems as well as blood cholesterol levels. Mushrooms can also have a positive effect in diseases like arteriosclerosis, kidney failure and high blood pressure, as well as helping in strengthening the immunity system, thus delaying unfavorable conditions of aging.

Research has shown that mushrooms, with their B-complex vitamins, have a positive influence on the nervous system. The mushroom offers a good alternative for anemia, a disease that arises from a deficiency in folic acid and it also helps to regulate the blood sugar level. Mushrooms are often recommended for patients with liver and kidney diseases, as well as being a good source of protein for patients suffering from gout, for it causes the formation of only a small amount of uric acid at the end of the digestion metabolism. Here we provide more specific information about certain species of mushrooms:

Shiitake (lentinula edodes)

This species is cultivated and sold in Japan and China, where it is known as “the elixir of life” or “the secret of long life.” It is traditionally used in wedding meals. This mushroom is effective primarily in the prevention of apoplexy and arteriosclerosis. It is also used in many cancer research programs, due to its antitumor activity. A polysaccharide known as lentinan that is found in this species can suppress sarcoma 180, a solid type tumor, a feature that adds to the value of this mushroom. Patients are advised to consume shiitake mushrooms during chemotherapy.

In Japan, around fifty different types of enzymes have been derived from the shiitake mushroom. These enzymes include pepsin and tripsin, which are used in the treatment of some gastric diseases, as well as asparaginase, which makes up a part of leukemia treatment for children. This species is rich in proteins, vitamins, and minerals. The consumption of 100 grams of fresh mushroom generates only 28 calories, thus making it a good alternative as a food that has limited energy intake. Mushrooms have only a small amount of A and E vitamins, but a large quantity of ergosterol (provitamin D2); this can change to D2 vitamin under sunlight or artificial light. D2 vitamin can adjust the phosphor and calcium balance, thereby contributing to bone and muscle development and preventing rickets. It has been found that the eritadenine compound that is contained in this mushroom reduces blood cholesterol at a rate of 25–45%. This species is known to be useful for all the health problems listed above (regulating blood circulation, apoplexy, arteriosclerosis, kidney failure, and high blood pressure; destroying bacteria, virus, pathogenic fungi).

Pleurotus spp.

This species is rich in proteins, only being surpassed by legumes. Mineral salts, like calcium, phosphor, and iron are contained in this species, in amounts that are proportionally twice as much as those found in beef or fowl. Among mushrooms, pleurotus has the highest levels of B1 vitamin (tiamin) and B2 vitamin (riboflavin).

Hemagglutinin, a substance that causes the agglutination of red blood cells, is contained in pleurotus ostreatus and pleurotus spodoleucus species. Eight of the eighteen amino acids found in pleurotus ostreatus are essential for human life. Extracts obtained from pleurotus spores trigger the formation of interferon, which is the first defense mechanism against viral infections. These spores have been found to help prevent flu and paralyses in laboratory animals.

Some mushroom species have been shown to be effective in strengthening the immune system. Chemotherapy applications used primarily in cancer and some other diseases are known to have many side effects, some of which are severe and can lead to other diseases. The toxic effects of some medications might pave the way for other infections, damaging the kidneys and liver. It is thanks to God, the Healer, that the mushroom is one among millions of other sources of healing that can be found in nature, waiting for us to discover them.

Basic nutrients for Agaricus bisporus %

Fat 0.35

Protein 3.43

Carbohydrate 3.78

Ash 0.71

Humidity 91.73

Minerals (ppm)

Zinc 5.46

Copper 1.59

Potassium 2445.50

Iron 8.73

Calcium 39.60

Chromium Iz

Phosphorus 882.30

Vitamins dissolved in water (mg/100g)

B1 (Tiamin) 0.094

B2 (Riboflavin) 0.396

Folic acid 0.078

C (Ascorbic acid) 2.29

Niasin 5.35

Scientifically known as Daucus Carota, carrots categorically are in the same family as fennel, cumin, dill, celery and parsley. They mainly originated in geographies of Central Asia and Middle East and their original flavor were somewhat different to the contemporary ones. The carrot as a plant stores its foodstuff in its roots. Besides their common use for consumption, they can be juiced or grated. They bring a distinct flavor when used in salads and meals. Although generally considered to be orange, yet carrots’ color can be as diverse as green, red, white and even purple.

Some astounding medical benefits

Created rich in Vitamin A carotene, carrot is an excellent source of antioxidant for the treatment of cancer and protection from some cardiovascular diseases. They are also instrumental for the regulation of sugar in our blood. The findings of a survey conducted on 1,300 patients, reveal those who eat carotene-rich foods such as carrot or squash, at least once a day, have about 60% less risk of cancer than those deficient in their carotene intakes. In specific terms, while the regular consumption of carotenoid reduces the risk of post-menopause breast cancer by an estimated 20%; on the other hand esophageal cancer, bladder cancer, uterine cancer, prostate cancer, colon cancer, throat cancer and lung cancer are believed to reduce the risk by an astounding 50%.

Scientists state that the risk-reducing influence of the carrot comes not only as a result of its beta-carotene ingredient but also from its alpha-carotene and some other elements.

How does carrot improve the quality of vision?

Unsurprisingly carrots are known for the goodness they bring to the eyes; particularly valuable for improving night vision. The beta carotene has been made to play a pivotal role in this respect. An incredibly sophisticated process eventuates as Vitamin A is converted in the liver into beta-carotene and is then carried to the retina of the eye. It is here when beta-carotene is converted to rhodopsin, imperative pigment that aids night vision. It is with rohdopsin that vision is sharpened and sight becomes possible in darker environments. On the contrary however, when there is Vitamin A deficiency in the body, night sight is adversely impacted. Moreover the antioxidant in beta-carotene has been equipped with an additional protective role against macular degeneration as well as cataract.

Carrot’s falcarinol and colon’s well being

The natural pesticide (falcarinol) found in carrots is believed to reduce the risk of cancer. In order to ascertain this relationship between falcarinol and cancer risk reduction, the Journal of Agricultural and Food Chemistry, conducted an experimental study on the subject. Three different groups of laboratory animals had been given precancerous colon lesions. The first group was fed with standard diet, the second group with freeze-dried carrots that contained a natural level of falcarinol while the third group was exclusively fed falcarionol/g derived from carrots. After 18 weeks period, the number of lesions which were given to potentially increase the class size, significantly decreased in those rats fed with one of the two experimental treatments. The finding demonstrated that dietary treatments with carrot’s falcarinol caused delay and in some cases the retardation in the development of large tumors.

This established a significant relationship between those critical endowed carrot contents and the risk-reduction of cancerous tumors.

Carrots and lung protection

Overtime a number of studies have been conducted and research have established direct link between Vitamin A and its role in the protection of lungs. The scientifically established relationship between Vitamin A, pneumonia and emphysema, found that the benzo(a)pyrene, the main carcinogen in cigarette smoke causes the Vitamin A to diminish. This is especially true when long term smoke addicts who have also had poor Vitamin A diet, causes more cancer-related diseases and emphysema.

Earlier studies have also demonstrated that a diet poor in Vitamin A causes emphysema. Subsequent studies have further substantiated that a diet rich in Vitamin A can help reduce emphysema. Indisputably carrots are rich in their Vitamin A reserves. Carrots have been also made with the capacity to aid and protect our lungs.

Experts are therefore of the opinion that carrot is stomach and intestines’ close friend. It can be said that their overall benefits can range from blood-formation, to strength, from diarrhea control, to being laxative, to their help with bile discharges and the strengthening of the liver brings to attention the remarkably latent benefits within carrots and makes them an indispensable vegetable beyond the immediate value of taste and color.

This discovery about carrots, amongst innumerable other vegetables, virtually makes the earth a mighty pharmacy which is orderly fashioned with numerous therapeutic qualities in the form of vegetables and herbs spread out in abundance. Quite substantially it appears that not only do they attract with their beauty and color the gazes of our eyes; not only do they afford us with innumerable varieties of tastes and flavors but in addition with the use of their innate given potentials they work extraordinarily and in remedial manner whilst in our bodies.

All this appropriately recalls to mind the Might and Power of God Almighty as eloquently expressed in the Quran “Who is it that provides for you from heaven and earth?” (Quran Al-Yunus, 10:31)

All parents do everything they can to keep their children healthy. The creation of a baby in a mother’s womb still remains a wonder not fully explained by scientists. Birth has been a mystery in the life of human beings since the beginning of history. Religious sources show the phases of a baby’s growth in the mother’s womb, the perfect design of the environment that supports the needy baby with everything it needs, and its birth, all as examples of God’s mercy and power. Although the whole process of pregnancy develops with almost no interference from outside, there are some precautions that parents can take to have a healthier baby.

How to start taking care of a baby even before pregnancy

Science makes it clear that we should not wait until we hold a baby in our arms before we start taking care of him or her. But how can we take care of a baby even before conception? Well, one of the answers is quite simple: by taking folic acid! If women have enough folic acid, vitamin B complex, in their bodies before pregnancy, this vitamin B complex can reduce the risk of neural birth defects by up to 70%. Neural tube defects (NTD) are a group of congenital birth defects that influence the central nervous system. The neural tube forms in the embryo between 4 to 6 weeks after conception and then closes. The neural tube eventually becomes the baby’s spinal cord, spine, brain, and skull. If the neural tube does not close properly, the baby may have neural birth defects, in which case the baby lacks either a developing brain, spinal cord or both. NTDs occur very early in pregnancy, even before most women know that they are pregnant. The most common neural birth defects are anencephaly and spina bifida. In anencephaly, the brain is either not fully developed or is completely absent, while in spina bifida part of the baby’s spinal cord remains outside the body.

Folate deficiency and folic acid

Folate, also called vitamin B9, is a water-soluble vitamin. It is essential to human life and is found naturally in some foods such as liver, citrus fruits and juices, whole grains, and dark green leafy vegetables. Folic acid is the synthetic form of folate. Folic acid can be obtained from supplements and fortified breads and cereals. Both folic acid and folate work for the same purpose, and in this article the terms are used interchangeably.

In folate deficiency, the body is unable to transport folic acid to the brain, resulting in mobility problems, blindness and seizures. Pregnant women in particular can be at great risk of giving birth to low-birthweight, premature babies who may have neural birth defects. In children, folate deficiency can slow general development. In adults, a type of anemia appears in long-term folate deficiency. There are also other signs of folate deficiency such as headaches, loss of appetite, sore tongue, diarrhea, forgetfulness and irritability.

Why folic acid is important

Folic acid plays a very important role in various body processes including cell maintenance and repair, formation of red blood cells (which provide oxygen to tissue), formation of white blood cells (which defend the body against infectious disease), synthesis of DNA (hereditary material) and amino acid metabolism. It also plays a crucial role in preventing human illness. Folic acid supplements cannot prevent stroke or heart disease, but studies have shown that it can reduce the risk of heart attack and stroke. Recent research shows that it supports the functioning of blood vessels, which improves the blood flow to the heart. In addition, folic acid helps to protect against the development of some forms of cancer, particularly colon, cervical, esophageal, breast, and stomach cancers.

A number of scientific experiments have shown that people who suffer from Alzheimer’s disease have low levels of folic acid in their blood. Thus, it is not surprising that folic acid is crucial for brain function and plays an important role in mental and emotional health.

If you are a married woman and have plans to have a child some day, you should definitely start to take folate because by the time you know you are pregnant, your baby’s brain and spine will already have been formed. This is why it is important for women to maintain sufficient levels of folic acid all through their child-bearing age even if they are not planning a pregnancy.

Should only women take folic acid?

No, not really. Every adult man and woman should consume it every day to reduce their risk of heart disease, colon cancer, and stroke.

If this is a vitamin that could change our life forever, how much should we consume and where can we get it from? You can get your folic acid naturally from foods such as liver, nuts, peanut butter, dried peas and beans, oranges, tomato and pineapple juice, avocados, cantaloupes, asparagus, and leafy green vegetables. Some breakfast cereals with 100% of the recommended daily allowance per serving are Crunchy Nuggets, Multi-Grain Cheerios Plus, Product 19, Whole-Grain Total, Total Corn- Flakes, Total Raisin Bran, and Special K. It can also be obtained from other, less processed grain products such as bread, pasta, and rice. Taking a multivitamin containing the recommended daily allowance of 400 micrograms is another option. The following table suggests a variety of dietary sources of folate.

Table 1: Selected Food Sources of Folate and Folic Acid

* Items marked with an asterisk (*) are fortified with folic acid as part of the Folate Fortification Program.

^ DV = Daily Value. DVs are reference numbers developed by the Food and Drug Administration (FDA) to help consumers determine if a food contains a lot or a little of a specific nutrient.

Sehnaz Dogu Ekicikol obtained a master’s degree on Microbiology from Georgia State University.

References

• Zittoun J. Anemias due to disorder of folate, vitamin B12 and transcobalamin metabolism. Rev Prat 1993;43:1358–63.
• Herbert V. Folic Acid. In: Shils M, Olson J, Shike M, Ross AC, ed. Nutrition in Health and Disease. Baltimore: Williams & Wilkins, 1999.
• Kamen B. Folate and antifolate pharmacology. Semin Oncol 1997;24:S18-30-S18-39.
• Agriculture’s Nutrient Database Web site: http://www.nal.usda.gov/fnic/cgi-bin/nut_search.pl.
• http://dietary-supplements.info.nih.gov/factsheets/folate.asp
• http://www.cdc.gov/ncbddd/folicacid/

It is worth contemplating that humans are in need of microorganisms to survive and that living things as insignificant (!) as bacteria are necessary to synthesize B12 vitamin. Why our so-called bacteria ancestors (!) from which we evolved – as some claim – lost this ability to synthesize B12 vitamin which was, and still is, vital for survival, is a challenging question for those scientists who support the theory of evolution.

The journey of B₁₂ in our body

Cobalamin, which is taken in with food, is absorbed by the final section (ileum) of the small intestine and transported into the blood by receptors on the cell membrane. For B12 to be absorbed into the blood, it is necessary to have an “intrinsic factor” bound to this vitamin. The intrinsic factor is a glycoprotein produced in parietal cells that secrete gastric acid. After the absorption, the vitamin binds to transcobalamin, a carrier protein found in the blood, and it is then being bound with transcobalamin II so that it can penetrate the cells. B12 can be stored in the liver to meet the needs of our body for a long time. A deficiency in cobalamin due to a poor diet (e.g., vegetarians) or a failure to produce the intrinsic factor in the stomach may result in pernicious anemia, which is fatal. Cobalamin deficiency negatively affects DNA synthesis, which is necessary for production of new cells, particularly in the division of the stem cells that are assigned to construct new red blood cells. This is followed by the circulation of cells that will generate underdeveloped red blood cells; these cells will not be able to function properly and will have larger diameters.

The training of parietal cells

If the stomach is removed or cannot produce the intrinsic factor, it is impossible for B12 to be absorbed. It is worth reflecting on the wisdom of why an organ like the stomach, the main duty of which is to partially digest food and convey it to the intestines, synthesizes intrinsic factor. How can the stomach know that our body is in need of this protein? How did it become able to synthesize this very special composition of glucose and protein which is so necessary to absorb intrinsic factor through the gastrointestinal tract? Why doesn’t our body produce the vitamin in the first place, instead of binding it to such a complex molecule? And how do the parietal cells know what is necessary to bind this vitamin, the use of which they cannot understand, although they have never been trained in bio-chemistry, physiology, or pharmacology? In which laboratory did these cells synthesize and test this compound?

The intrinsic factor

In order to decompose proteins into amino acids, the stomach secretes hydrochloric acid and an enzyme called pepsinogen. Parietal cells that secrete acid also produce a protein (intrinsic factor) which is not damaged by the acid or the pepsinogen enzyme. How were these cells able to develop a synthesis in which proteins do not decompose, which can protect them from the acid in the stomach, and bind themselves to a vitamin like B12, which is absorbed only in very small quantities?

The hydrochloric acid secreted in the stomach is like bleach and it irritates anywhere that it goes other than the stomach. Should even the slightest quantity of this acid pass into esophagus (reflux, diaphragm boiling) it can cause severe burning. It is amazing that B12 is found and bound in a cauldron like the stomach, but is not damaged by the acid produced when the stomach is filled with food and drink.

The intrinsic factor bound with the vitamin goes on its journey and it reaches the absorption region in the last section of the small intestines. During absorption, the gates on the cell membrane of the intestines open up only to allow the B12 intrinsic factor compound. Maintained in the intestinal cell for a while, the B12 vitamin binds to the transporter transcobalamin and is conveyed to the cells through the blood. After reaching a cell, the vitamin, needed by the entire body, is bound to another transporter: transcobalamin II.

Some components, although they appear to be very simple, must be supplied from outside our bodies if we are to survive. B12 vitamin is one such component, and it certainly deserves to be studied well.

Vitamin basics

Vitamins and minerals are key nutrients that are essential in the regular functioning of the human body. They are needed in small amounts and are usually acquired from vegetables and fruits (Dobson 12). When acquired properly, vitamins can competently play the role assigned to them and they can observe their duties, such as to keep the immune system running, contribute to the structural integrity of the body, and strengthen the sensory systems. Their deficiency in the body leads to problems in these systems, which may result in lethal risks for health. For example, “lack of vitamin D damages immunity to cause cancers, diabetes and infections” (Mirkin).

Vitamins can be classified as water soluble and fat soluble. Generally, the vitamins that are soluble in water are absorbed by the body in the quantities that are needed. The excess is excreted in urine. Thus, it appears that abundant use of pills containing such vitamins produces nothing but expensive urine. As for the vitamins that are soluble in fat, their excess is stored in fat tissues and is retrieved in case of need (“Vitamins and Minerals”). This is an undesired effect, because it tires the body, which is otherwise a perfectly adjusted system.

Motivation for vitamin supplements

In the last century, a lot of research has been done to establish the amounts of vitamins and minerals needed for regular functioning of the body. With this knowledge, there is a growing concern among the public about their nutrition in recent years. People often think that the foods they are consuming do not contain necessary or sufficient amounts of vitamins and minerals.

It is not difficult to see that this concern has been formed by the artificial agendas of certain specialists. These specialists use methods that evoke feelings of anxiety, fear, desire, and the wish for perfection. The visual media and the press have certainly been the main and most effective means of propagating this agenda. Based on consultation with the specialists, vitamin-producing companies make promises to the consumers through advertisements that highlight how good vitamins are for children, adolescents and the elderly. They promise, for example, that if certain vitamins are used, people will feel better, improve their memory or remove aging effects. They claim that some of the vitamins they are selling have a healing or preventive power against diseases about which people are most concerned or fearful. Cancer, cardiovascular problems and obesity are among the most commonly emphasized such diseases. In the same way, abusing people’s desire for a long life, they claim that some vitamins increase life expectancy. For children, their inherent desire to be like adults is abused and they are promised that if they use certain vitamins they will be strong. These claims are reinforced with video clips in order to make them appear more realistic, and they are further supported by frequent repetition in the visual media.

Food supplements designed to meet the needs of the body are also put in “costumes” to allure the consumers. Product packaging uses big bullet points to present information about their extra vitamin content. In parallel to this, in the stores where these vitamins are sold, life-size pictures of famous or well-built people are displayed.

The Vitamin Market

As a result of all these efforts, many people think that a healthy life is not possible without vitamin pills. According to a survey by the USDA (United States Department of Agriculture) two decades ago, around fifty percent of the population from 19–50 takes a multivitamin pill every day. That survey showed a significant increase compared to another one performed five years earlier (Driskell). According to this trend, the vitamin supplement consumption is likely to have achieved much higher levels in our time.

Thus, an enormous market has formed for vitamin and mineral pills. It is estimated that this market amounts to an annual sales value between three and five billion dollars (Anderson, Wilken). With a drive to get a share of the sales, all supermarket chains have opened sections for vitamin pills and sell various kinds of vitamin supplements. Not only is the vitamin industry doing all these promotions for its own benefit, but media companies are also thriving on such advertisements. Unfortunately, this is sometimes a major reason for the media not to go after certain issues.

What is wrong?

Research shows that people get the correct quantity of vitamins and minerals if they consume a variety of natural foods and drinks. In countries with a high per capita income, some foods and drinks are even enriched with extra vitamins to ensure that vitamins are taken in sufficient amounts. As a result, for a person who is on a normal diet, a multivitamin pill is very likely to be excessive. With regard to these pills, nobody knows what amount is good for which person under what conditions. It is strange that the quantity of fruits and vegetables corresponding to the same amount of vitamin contained in a multivitamin pill is not revealed. Perhaps if this were calculated, the insanity of vitamin supplements would become evident. Do we really need to eat as many vegetables as a cow or a horse?

At the top of the direct vitamin intake options are vitamin pills. The majority of vitamin pills are marketed as a multivitamin-combinations of different vitamins and minerals. Supplying various combinations of vitamins in a single pill seems like a good idea at first. However, when we look at the production of vitamin pills, we see that the production process has not been standardized. Each company makes its own vitamin combinations and markets them. On top of their content, the daily consumption of synthetic vitamin pills is also variable based on the demands of the individual consumer. Although some companies include a recommendation on the packaging, in the end they say that their product can be consumed to the extent it is needed. For many vitamin pills, information about their solubility in water or fat is not present either. However, such pieces of information are of vital importance for their healthy consumption.

In recent times, with their wider use, these synthetic pills have been held responsible for health problems, contradicting expectations of health improvement, but so far they have not gained a bad reputation related to side-effect or harm. The prevailing view is that the more vitamins one takes, the better one’s health. This view might be true for natural vitamins; however, it is not so for synthetic vitamins. Generally, side-effects are associated with high dosages and undiluted intake, neither of which occurs in their natural counterparts.

Multivitamin pills are usually combined with minerals. Thus, while taking vitamin supplements, minerals are also taken, regardless of the need for them. However, similar to vitamins, minerals also are bad for human health when taken in excess. They interact with and counteract each other, and hence they disturb the body’s equilibrium.

In a study by Goran Bjelakovic and Christian Gluud, which was published in the journal of National Cancer Institute, it is stated that “Our diets typically contain safe levels of vitamins, but high-level antioxidant supplements could potentially upset an important physiological balance” (Bjelakovic, Gluud 742). They claim that antioxidant vitamins (A, C, E) do not provide any benefit when consumed in pills: if they are used as such, each results in certain forms of harm according to their function in the body. Bjelakovic and Gluud proved that such vitamin pills neither prevent nor cure cancer, that they do not protect the cardiovascular system, do not increase life expectancy nor alleviate the effects of aging. On the contrary, they showed that these antioxidant vitamin pills increase the risk of the diseases mentioned above. For example, a male person who is taking one multivitamin pill per day is doubling his risk for developing prostate cancer.

Some supplements can also have drug-like effects which present risks for people with certain medical conditions. A vitamin supplement brand was found to have potentially dangerous interactions with a number of prescription drugs (“‘Miracle’ Health Claims”).

At the very least, such side-effect-related cases call for a sound understanding of how these substances interact with the body. Can the human body convert synthetic vitamins to a usable form? Can they be stored and used later in case of vitamin deficiency? Are vitamin supplements, especially synthetic pills, as effective as natural vitamin sources, such as fruits and vegetables? What are the side effects associated with synthetic vitamins? What happens to vitamins in the case of overdose? Unless there are factual answers to these questions, vitamin pills should not be considered safe to use, and people should not use vitamin and mineral pills without consulting a doctor (“Vitamins and Minerals”).

Watch out for your health!

Here is the dilemma now: on the one hand, vitamin manufacturers are struggling to show the benefits of vitamin pills so that they make more profit; on the other hand, there is other research proving the detrimental effects of vitamin pills. At this point, it is nice to see a parallel dilemma in the fast-food market. If you go to a fast-food restaurant, their “nutrition facts” sheets show how healthy their food is. They even compare their food with other companies’ food in order to highlight their quality. However, there is a general consensus about unhealthiness of fast-food as demonstrated in the movie “Supersize Me”. Be it the food industry or the dietary supplement industry, there are claims from the producers which contradict the facts observed in real life. What to believe and who to trust are not clear.

One recourse in this ambivalence is the federal regulations or official advice from government scientists. In theory, health-care standards are established by either legislators or health organizations. However, in practice, there is a lack of institutes which can undertake the control of production of synthetic vitamin pills. In the US, for example, according to the Federal Trade Commission’s report, “Dietary supplements are not required to undergo government testing or review before they are marketed” (“Miracle’ Health Claims”). So, existing US health organizations, such as the FDA (Food and Drug Administration), do not accept any responsibility.

The main reason for not checking the harm associated with vitamin pills is that their side effects emerge in the long run. Consumers do not have the means to prove their cases, and consumer associations do not have enough financial power to take legal action against the producer companies. Therefore, there is no legal or practical base to pursue allegations related to the use of vitamin supplements. Given all this, using vitamin and mineral supplements is not very different from gambling with our health.

The above discussion provides enough information to evoke questions in the mind of the reader. Protecting people from the harm caused by vitamin pills is not possible through financial or judicial means at present, but it may be possible in the future through their long term results appearing as people with severe health problems. Let us hope that the people who have control over these issues will act in consideration of everybody’s health as an invaluable trust granted to them.

Alper Bursali is a senior student at West Virginia University, Biology Department.

References

• Bjelakovic, Goran, and Christian Gluud. “Surviving Antioxidant Supplements.” Editorial. Journal of the National Cancer Institute, 16 May 2007:742-743.
• Dobson, Roger. “The A to Z of vitamins;” Independent Extra, 6 Mar. 2007. 25 June. 2007 http://web.lexis-nexis.com.www.libproxy.wvu.edu/universe/printdoc
• Driskell, Judy A. Vitamin-Mineral Supplements and Their Usage by Adults. 28 June 2007 http://www.healthgoods.com/Education/Nutrition_Information/
• Nutritional_Supplements/supplements_usage_adults.htm
• Familydoctor.org 2004. Vitamins and Minerals: What You Should Know. Sept. 2004 http://familydoctor.org/online/famdocen/
• home/otc-center/otc-medicines/863.html
• Fogle, C., J. Anderson and K. Wilken. Mar. 2002. 29 June 2007 http://www.ext.colostate.edu/PUBS/foodnut/09338.pdf.
• ‘Miracle’ Health Claims: Add a Dose of Skepticism. September 2001. Federal Trade Commission. 20 June 2007 http://www.ftc.gov/bcp/conline/pubs/health/frdheal.shtm
• Mirkin, Gabe. Lack of Vitamin D causes Cancer. 5 Mar. 2007. 27 June 2007 http://www.drmirkin.com/nutrition/1337.html
• Sardi, Bill. Government/Scientific/Pharmaceutical/News Media Grip Over Dietary Supplements. 23 Jan. 2006. 27 June 2007 http://www.policestateplanning.com/dietary_supplements.htm

The skin, which covers a total surface area of approximately 1.65 m2 and which weighs in total about 9.5 kg, is surely the largest and the heaviest organ of the human body; yet its miraculous functions are still a puzzle to us.

A layered structure

The human skin is composed of three layers: the epidermis (outermost layer), the dermis (vascular connective tissue below the epidermis) and the hypodermis (the deepest portion of the skin), each of which has a very complex metabolism of its own. Each of the structures of which the skin is comprised has a wide variety of functions; all of these functions must be in order if we are to maintain our good health. In particular the epidermis and the dermis each have their own distinct functions, but also share some duties, and all of these are essential for the survival of the human. The thickness of the skin varies from 8 mm on the palms and soles of the feet to nearly less than 1 mm on the eyelids. Within the epidermis are found four dif¬ferent types of cells that undertake different tasks; the appearance of our skin, in terms of texture, evenness of color, hydration, and overall youthfulness and constitutional health, is greatly dependent on the interaction of these cellular functions.

A single organ with several functions

It is very interesting that the majority of people are not aware of the fact that the skin is one organ.

Not only does it cover the body, our skin performs many amazing tasks such as,

-helping with water conservation,

-helping with the maintenance of body temperature,

-perception of touch

-providing a barrier to harmful germs,

-storing fat,

-storing vitamin D,

-acting as a mechanical barrier against knocks or bumps,

-helping in the removal of the waste products of metabolism

-providing protection against environmental influences, such as cold or high temperatures, and destructive ultraviolet rays, as well.

It is common knowledge that the major task of our skin is to protect the human body from harmful environmental factors. It is, indisputable that the fundamental purpose of the skin is to provide a flexible, protective shield between us and the outside world. This is made possible by the layers of flattened epithelial cells which hinder micro-organisms and chemicals from entering the body.

Constant replacement

The benefits we have mentioned would not last long, however, if skin cells were not renewed. This amazing regeneration process happens through a replacement operation that is dependent on a continuous cell division in the basal layer. As the cells move towards the outer surface they lose their softness. Consequently, they gradually die off and stiffen. Dead cells are constantly sloughed off from the upper surface of the epidermis and are continuously shed; they are replaced by new cells that are generated in the deeper layers. This process is often referred to as “cellular renewal.” As cells progress through the various stages, they finally stiffen and die or keratinize. This dead cell layer, or keratinocytes, makes up the outermost layer of the epidermis, the stratum corneum. These hardened and cornified cells are designed by our Creator to act as a protective barrier; otherwise, living cells would not be able to provide the protective qualities necessary to isolate the living tissue from exposure to possible detrimental substances and organisms. The living epidermal cells die by an extremely sophisticated process, displaying a voluntary self-sacrifice that enables humans survive, an evident blessing from our Most Gracious Lord.

Regulation of body temperature

The regulation of temperature is considered to be one of the major duties given to the skin. We naturally lose water through constant evaporation throughout our lives. It is of utmost importance that the loss of too much body fluid is prevented. By narrowing or widening the capillary blood vessels and also by means of numerous sweat glands, evaporation on the surface enables our skin to become cooler or warmer, in a strictly limited range of temperatures. The fat cells of the skin prevent losing too much heat, and when the body overheats, the skin’s extensive small blood vessels carry warm blood to the surface where it is cooled. So, as we can deduce from this, the main task of the skin is to prevent the loss of body fluids through evaporation.

Another task of the skin is the storing of fat and the production of vitamin D [25-dihydroxycholecalciferol]. Vitamin D is a fat-soluble vitamin that is found in food and can also be processed in our body after exposure to ultraviolet (UV) rays from the sun. Sunshine is a significant source of vitamin D because the UV rays from the sun stimulate the synthesis of vitamin D in the skin. This fundamental feature of our skin is, clearly, indispensable to our skeletal development.

The witness

The human skin has also a function in sense communication with the environment. It gathers sensory information from the environment; this is performed by means of a great number of receptors (for example, those for warmth and cold) and intraepithelial nerve endings. Nerve cells in the skin form the body’s first contact with the outer world. At the moment of birth, an infant’s first experiences of the physical world are perceived through the sense of touch. Nerve cells allow the skin to receive and transmit signals from touch, pain, tickling, etc. As the skin is the boundary between a living creature and the world around it, it is also the physical interface between the creature and other creatures and the world. Hence it is the location of all contact, good or bad in kind. The Qur’an declares that the skin will also testify when we are called to account on the Day of Judgment:

Until when they reach it, their ears, and their eyes, and their skins will bear witness against them as to all that they did habitually. They will ask their skins, “Why have you borne witness against us?” They will answer: “God Who makes everything speak has made us speak.” It is He Who has created you in the first instance, and to Him you are being brought back. You did not seek to veil yourselves (when sinning) without ever considering that your ears or your eyes or your skins would one day bear witness against you. (Fussilat 41:21-22)

As pointed out in the verse …the abode of the Hereafter is truly alive (29:64), everything in the Abode of Hereafter will be alive. So, like every part of a human being, the skin will bear witness for or against them. The verse implies that it is the medium where all our contact is recorded and it will be an ideal witness.

Wounds and healing

Another astounding mission of our skin is its role in healing wounds. The human skin has remarkable selfhealing properties, which obviously point to an intelligent design. A skin wound heals from the bottom up and from the edges inward. In the first stages of healing, the basic connective tissue of the skin moves into the injured area. The depth of the wound determines how well it will heal; the regeneration process begins immediately, but we still do not know what the trigger is. As a wound heals, the edges are drawn together by a process called contracture. The most amazing part of this phenomenon are the later stages of healing. It is as if all the cells are fully aware when and where to end the repair. Nobody knows why they abruptly stop working and how they finalize restoration.

A shield against germs

Our skin also serves us by organizing and activating the immune system. Some specific cells, which form a network in the epidermis or in the outer layer of skin, play an important part in this activity, by regulating the immune response to germs. As a major contributor to the body’s immune system, constituting the first line of de fense in keeping out bacteria, viruses, and other organisms that invade the body, the skin is home to enormous quantities of T-lymphocytes, or T-cells. Those domestic defense soldiers attack and destroy bacteria, fungi, viruses, parasites, toxins, and cancerous cells that can cause disease. Thus, the skin is both a watertight barrier surrounding and protecting our body from a number of external assaults, never letting the undesired pathogenic germs penetrate.

Our Almighty and Everlasting Creator has granted us this gift of skin. He knows what those who are in need are in need of, and it is obvious that He is aware of the need of our cells, our organs, and our living metabolism, thus He has given the most favorable structural design to the human body. Just before we pray to Him, we should remember that the more consistent our demands, the more bountiful He will ordain. Frankly, there seems to be no way to explain the miracle of skin other than attributing it to the All- Beneficent God.

References

1. Cognis Deutschland GmbH & Co. KG Skin Care Forum 2006.

2. ABPI – The Association of the British Pharmaceutical Industry.

3. Dr. K.K. LO, Social Hygiene Handbook – 2nd Edition.

4. Helmut Leonhardt, His, Zyt und Mikroanatomie des Menschen, Vol. 3, Thieme, Stuttgart 1990.

5. H. Brannon M.D., The skin anatomy ed. 2002.

6. Beauty Clinics Hashmi.com. Skin Analysis 2005.

7. Goldsmith LA, Biochem and Physiology of the Skin 2nd ed NY Oxford University Press, 1991. 8. Breathnach AS. Atlas of the Ultrastructure of Human Skin. London: J. & A. Churchill, 1971.

9. Elias PM. Epidermal lipids, membranes, and keratinization. Int J Dermatol 1981; 20: 1-19.

10. National Skin Care Institute 2005-2006 website.

11. Ali Ünal, The Qur’an with Annotated Interpretation in Modern English, The Light, Inc., NJ:2006.